Hub : Genes

HMGCL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1660	0.0410	6.4e-12	0.118	0.107	0.130	0.119	0.120	3.4e-14	6.1e-13	1.6e-15	2.8e-14	2.1e-14
2	GTEx	Brain Cerebellum	0.3010	0.0980	1.4e-04	0.056	NA	0.055	NA	0.085	9.5e-03	NA	1.0e-02	NA	1.7e-03
3	GTEx	Brain Cortex	0.2150	0.0900	2.0e-03	0.091	NA	0.121	NA	0.072	1.7e-03	NA	3.2e-04	NA	5.0e-03
4	GTEx	Heart Left Ventricle	0.1620	0.0543	6.2e-04	0.104	NA	0.109	NA	0.105	3.4e-06	NA	2.1e-06	NA	3.3e-06
5	GTEx	Liver	0.2690	0.1020	2.2e-03	0.041	NA	0.008	NA	0.021	2.7e-02	NA	1.9e-01	NA	8.2e-02
6	GTEx	Muscle Skeletal	0.0827	0.0289	8.1e-05	0.069	NA	0.049	NA	0.057	2.7e-07	NA	1.5e-05	NA	2.6e-06
7	GTEx	Thyroid	0.1000	0.0360	1.7e-04	0.102	NA	0.087	NA	0.089	3.3e-08	NA	3.7e-07	NA	2.5e-07
8	ROSMAP	Brain Pre-frontal Cortex	0.1508	0.0298	0.0e+00	0.224	0.171	0.226	0.211	0.226	2.7e-28	1.9e-21	1.2e-28	1.3e-26	1.5e-28
9	TCGA	Lung Squamous Cell Carcinoma	0.0291	0.0244	9.3e-03	0.004	0.013	0.010	NA	0.008	9.9e-02	1.1e-02	2.1e-02	NA	3.4e-02
10	TCGA	Stomach Adenocarcinoma	0.0690	0.0480	5.4e-03	0.033	0.014	0.008	NA	0.016	1.8e-03	3.0e-02	8.2e-02	NA	2.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.5	0.8	4.4	0.9	-0.5	0.2	0.4	-0.2	-0.2	-0.5	-0.0	-1.4	-2.1
Bipolar Disorder or Schizophrenia	0.2	0.5	2.8	0.4	-0.4	-0.0	0.8	0.4	0.1	-0.2	0.2	-0.9	-1.7
Depressed Affect (Nagel 2018)	1.3	2.8	4.7	1.8	1.0	2.2	1.7	-1.4	2.1	2.1	2.1	1.1	0.2
Depression (Nagel 2018)	0.8	1.2	2.3	1.3	0.5	1.4	1.5	0.1	1.1	1.0	1.3	-0.3	-1.0
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.0	-1.7	-1.2	-1.6	-1.6	1.6	-1.6	-1.6	-1.7	-0.4	0.3
Neuroticism (Nagel 2018)	1.3	3.0	5.6	1.7	1.2	2.4	1.8	-1.7	2.1	2.1	2.2	0.7	-0.3
Schizophrenia (2018)	0.1	0.1	0.4	-0.3	-0.1	-0.3	0.5	0.7	0.3	0.2	0.3	-0.0	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.1	0.3	0.0	0.4	-0.9	0.7	0.7	0.6	1.1	1.2
Worry (Nagel 2018)	0.8	1.6	2.5	1.4	0.6	1.4	1.5	-1.6	1.5	1.4	1.6	0.1	-0.8
Alzheimer’s Disease (in mother)	1.2	1.4	3.3	1.4	1.8	1.7	0.3	-0.8	1.1	1.2	1.1	0.9	0.7
Alzheimer’s Disease (in father)	1.4	1.6	3.4	1.1	0.2	1.8	1.4	-0.7	1.6	1.6	1.7	0.3	-0.5
Alzheimer’s Disease (including proxy)	2.2	3.2	5.0	2.1	2.1	2.2	1.3	-1.4	2.0	2.1	2.1	1.1	0.4
Crohns Disease (2017)	0.5	1.0	3.2	-1.5	-0.5	-0.8	-1.8	0.8	-0.9	-0.9	-1.0	-0.3	-0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	-0.9	-0.8	-0.1	-0.7	0.1	-0.3	-0.3	-0.4	-0.3	-0.2
Ulcerative Colitis (UC)	0.1	0.3	0.7	0.2	-0.3	0.8	0.6	-0.8	0.5	0.5	0.5	0.0	-0.1
Major Depression (MDD)	0.6	0.7	2.5	0.9	0.7	0.6	1.0	-0.2	0.6	0.3	0.8	-1.1	-1.6
Reaction Time	1.6	3.1	5.6	2.0	0.1	0.9	1.8	-1.9	2.4	2.4	2.3	1.8	0.6
Verbal and Numeric Reasoning (VNR)	1.9	4.5	7.1	-2.7	-2.3	-2.6	-2.4	2.0	-2.2	-2.1	-2.3	-1.4	-0.3
Breast Cancer	0.2	0.6	2.1	-0.1	1.1	-1.0	-0.2	0.8	-0.3	-0.1	-0.4	0.9	1.4
Ovarian Cancer	0.6	0.7	2.4	-0.1	-1.6	-0.7	0.9	0.3	-0.3	-0.4	-0.2	-1.3	-1.3
Prostate Cancer	0.2	0.3	1.2	-0.6	-0.3	-1.1	-0.3	0.8	-0.3	-0.4	-0.3	-0.4	-0.2
Age at First Birth	0.5	0.7	3.6	0.9	1.9	0.4	0.5	-0.7	0.8	0.7	0.8	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	-0.4	0.3	-0.8	-0.5	0.4	-0.5	-0.3	-0.5	0.0	0.0
Coronary Artery Disease (CAD)	0.3	0.4	1.8	0.4	-0.1	-0.1	-1.0	1.4	-0.7	-0.5	-0.5	0.0	0.0
Crohns Disease (2012)	1.3	2.1	3.7	-1.9	-0.9	-0.9	-1.9	1.6	-1.6	-1.6	-1.6	-1.1	-0.7
Mean Putamen Volume	0.4	0.5	1.7	-0.7	0.7	-0.1	-0.3	0.8	-0.1	0.1	-0.2	1.1	1.3
Fasting Glucose	1.1	1.4	2.7	0.1	1.0	1.2	0.6	-0.5	1.6	1.3	1.3	1.6	1.4
HbA1C	2.5	2.8	5.4	-1.5	-1.8	-1.7	-0.7	1.3	-2.3	-2.1	-2.1	-1.5	-0.6
HDL Cholesterol	0.0	0.1	0.2	0.3	0.1	0.3	0.1	-0.1	0.4	0.4	0.3	0.0	0.0
LDL Cholesterol	0.1	0.2	0.8	0.9	0.5	0.4	0.8	0.3	0.3	0.3	0.4	0.0	0.0
Lupus	1.6	2.4	5.2	1.7	2.1	1.1	1.4	-2.3	1.6	1.5	1.7	0.8	-0.1
Neuroticism (2016)	0.7	1.0	1.6	1.1	0.6	1.0	1.0	-1.1	1.2	1.2	1.2	0.7	0.5
Primary Biliary Cirrhosis	0.2	0.2	1.0	-0.3	-0.1	-0.8	-0.5	1.0	0.3	0.3	0.2	0.4	0.2
Rheumatoid Arthritis	0.9	1.2	2.4	-1.6	-0.9	-1.4	-1.2	1.3	-0.6	-0.4	-0.7	0.8	1.4
Schizophrenia (2014)	0.1	0.2	0.9	0.2	0.0	-0.2	0.4	0.4	0.3	0.1	0.4	-0.3	-0.9
Triglycerides	2.8	4.6	14.4	3.0	3.8	2.0	2.3	-0.8	2.0	2.1	2.1	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-0.5	0.4	-1.2	-0.8	1.4	-1.0	-1.0	-1.0	0.0	0.0
Ulcerative Colitis	0.1	0.2	0.8	0.1	-0.3	0.9	0.3	-0.6	0.4	0.3	0.4	-0.3	-0.4
Blood Eosinophil Count	6.1	46.7	70.2	-5.7	-5.8	-7.3	-5.7	5.3	-8.3	-8.4	-7.9	-8.0	-4.7
Blood Platelet Count	0.1	1.1	7.2	1.1	2.7	0.4	1.1	0.6	0.1	0.1	0.0	0.6	0.7
Blood Red Count	3.1	29.8	43.0	-4.7	-4.7	-5.3	-4.0	5.4	-6.4	-6.6	-6.2	-6.2	-4.3
Blood White Count	0.6	4.7	20.2	-0.4	2.7	-1.4	-1.8	-1.4	0.2	0.6	-0.2	3.4	4.5
Heel T-Score	0.1	0.7	3.3	-0.2	-1.2	-0.7	0.5	0.2	-0.2	-0.4	-0.1	-1.2	-1.8
BMI	0.2	1.0	5.4	-0.8	1.0	0.2	-0.5	0.7	-0.5	-0.3	-0.7	1.3	2.3
Height	0.0	0.6	2.0	-0.7	-1.4	0.8	0.7	-0.8	-0.0	-0.2	0.2	-0.8	-1.0
Waist Hip Ratio (WHR)	0.8	3.4	10.3	0.3	-0.8	0.7	1.2	-3.2	2.0	2.1	1.8	2.4	1.9
Systolic Blood Pressure	3.3	16.6	24.6	-4.2	-3.2	-4.4	-3.6	4.7	-4.9	-5.0	-5.0	-3.1	-1.2
Smoking Status	0.2	0.4	1.0	-0.8	-1.0	-0.3	-0.7	-0.9	-0.0	0.0	-0.1	0.7	1.0
Allergy or Eczema	0.5	1.2	2.4	-0.3	-1.0	-1.1	-0.8	1.6	-1.1	-1.1	-1.0	-1.3	-1.3
Cardiovascular Disease	0.9	3.0	5.4	-2.0	-1.4	-2.3	-1.8	2.1	-1.6	-1.4	-1.9	0.5	1.7
Hypothyroidism (self reported)	6.7	15.5	29.6	4.6	3.1	5.4	3.9	-4.7	4.2	4.0	4.4	1.8	-0.0
Respiratory disease	0.7	1.5	3.2	-1.4	-1.0	-1.8	-1.6	1.1	-1.2	-1.2	-1.2	-0.7	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	-0.7	0.4	-0.1	-1.3	0.6	-0.6	-0.5	-0.8	0.6	1.1
Lung FEV1/FVC ratio	0.6	3.2	4.2	1.7	1.8	1.9	1.4	-1.9	2.0	2.0	1.9	1.9	1.4
Lung FVC	0.3	1.7	5.6	1.7	1.9	0.2	1.5	-0.2	0.6	0.3	0.8	-1.1	-2.4
Neuroticism	1.0	2.3	4.5	0.9	0.7	2.1	1.1	-1.3	1.9	2.0	1.8	1.7	1.0
Chronotype (morning person)	0.2	0.5	2.4	0.1	1.6	-0.6	-1.0	-0.8	-0.4	-0.3	-0.4	-0.0	0.6
Hair Pigment	0.1	2.4	9.2	-0.9	0.7	1.0	-0.9	-1.0	1.1	1.4	0.8	2.6	3.0
Tanning	0.1	1.6	2.4	-1.6	-0.9	-1.1	-1.3	1.3	-1.4	-1.4	-1.4	-1.2	-1.0
Hand grip strength (left)	0.3	0.8	3.4	1.2	1.8	1.0	0.9	-0.5	0.5	0.4	0.5	0.2	-0.1
Number of treatments/medications taken	1.5	2.7	6.7	-2.6	-0.9	-2.1	-1.8	1.3	-1.7	-1.6	-1.9	0.1	1.1
Average weekly spirits intake	0.9	1.1	2.8	-1.2	-0.4	-1.7	-1.4	0.2	-0.6	-0.5	-0.8	0.8	1.6
Sensitivity / hurt feelings	4.0	6.8	11.4	2.9	2.1	3.4	2.6	-2.8	2.9	2.9	3.0	1.8	0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	0.4	0.0	1.3	1.1	0.5	0.4	0.2	0.6	-0.7	-1.3
Hearing difficulty/problems: Yes	0.3	0.4	1.4	-1.2	0.2	-0.9	-0.3	-0.4	-0.8	-0.7	-0.8	-0.2	0.1
Relative age of first facial hair	0.1	0.2	0.5	-0.0	-0.3	-0.2	-0.0	-0.6	0.4	0.4	0.3	0.7	0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.7	-0.8	-0.4	-0.5	0.1	0.3	-0.4	-0.3	-0.3	-0.4	0.0
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.3	0.7	0.5	0.8	0.6	-0.6	1.2	1.3	1.1	1.5	1.3
Ever had hysterectomy (womb removed)	1.0	1.1	3.5	-1.3	-0.7	-1.9	-0.8	1.1	-1.0	-1.0	-1.1	-0.1	0.4
Systolic blood pressure, automated reading	2.6	7.7	11.4	-2.8	-1.7	-3.1	-2.8	3.4	-3.3	-3.3	-3.3	-2.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-1.0	-0.9	-0.3	-0.9	0.3	-0.2	-0.2	-0.4	0.6	1.2
Angina	1.0	1.3	1.9	1.0	1.0	0.9	1.2	-1.3	1.3	1.4	1.3	1.1	0.8
Medication for hormone replacement therapy	0.2	0.3	1.0	-0.5	0.3	0.1	0.1	-0.4	0.1	0.2	0.1	1.0	1.0
Vitamin and mineral supplements	0.5	0.6	1.7	-0.6	0.1	-1.0	-0.7	1.3	-0.9	-0.9	-1.0	-0.4	0.1
Supplements: Zinc	1.0	1.1	1.9	1.2	0.9	1.2	1.3	-1.4	1.1	1.0	1.2	0.1	-0.5
Medication: Co-codamol	2.9	3.4	6.2	-2.5	-2.0	-1.9	-1.9	1.9	-1.9	-1.9	-2.1	-0.9	0.0
Medication: Metformin	0.5	0.8	2.0	-0.3	1.0	-0.7	-1.4	1.1	-0.5	-0.4	-0.7	0.8	1.2
Diabetes (father)	0.5	0.7	1.2	-0.9	-1.1	-1.0	-0.8	0.8	-0.8	-0.8	-0.9	0.0	0.5
Diabetes (mother)	0.4	0.6	1.8	-1.3	0.6	-0.6	-0.9	0.7	-0.7	-0.6	-0.9	0.1	0.3
Severe depression (siblings)	0.5	0.6	2.2	0.1	-1.5	0.1	0.8	-0.1	-0.0	-0.2	0.1	-1.1	-1.4
Pack years adult smoking proportion	0.5	0.7	1.6	-0.7	0.3	-1.2	-1.2	0.8	-0.5	-0.3	-0.7	0.8	1.3
Impedance of leg (right)	2.1	10.4	21.0	-2.6	-4.6	-3.4	-1.7	2.3	-3.2	-3.3	-3.0	-4.0	-3.3
Leg fat-free mass (left)	0.3	1.4	3.7	0.5	1.3	1.9	0.3	-0.8	1.0	1.0	0.9	1.4	1.5
Trunk fat percentage	0.7	2.7	5.1	-2.2	-1.6	-1.2	-2.2	1.9	-1.5	-1.2	-1.7	0.4	1.8
Hand grip strength (right)	0.8	2.1	6.4	1.8	2.5	1.6	1.5	-1.1	1.3	1.1	1.4	0.6	-0.3
Townsend deprivation index at recruitment	0.5	0.7	2.2	-1.3	-0.8	-0.0	-0.6	0.7	-0.6	-0.5	-0.8	0.6	1.5
Current tobacco smoking	0.1	0.2	1.0	0.3	0.2	0.5	0.0	-1.0	0.3	0.3	0.3	-0.0	0.1
Average weekly fortified wine intake	0.5	0.5	1.9	0.0	-1.4	0.0	1.2	0.4	-0.2	-0.3	-0.0	-0.8	-1.0
Maternal smoking around birth	0.3	0.4	1.2	-1.0	-0.3	-1.1	-0.4	0.3	-0.4	-0.4	-0.5	0.3	0.6
Fed-up feelings	4.4	8.0	12.8	3.0	1.7	3.5	3.4	-2.6	3.5	3.4	3.6	1.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	3.7	1.5	0.4	1.3	1.9	-0.8	1.6	1.5	1.7	0.5	-0.7
Relative age voice broke	0.4	0.6	1.5	-0.3	-0.8	0.4	0.4	-1.1	0.6	0.7	0.5	1.2	1.2
Taking other prescription medications	0.7	1.1	3.0	-1.7	-1.1	-1.1	-1.0	0.6	-1.1	-1.0	-1.2	-0.5	0.5
Age when periods started (menarche)	1.5	3.6	6.8	0.9	0.8	2.0	0.5	-1.8	2.2	2.3	2.0	2.6	2.5
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.6	-2.1	-0.7	-1.9	-1.6	0.5	-1.4	-1.3	-1.5	-0.5	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.3	0.1	0.5	-0.2	-0.4	-0.3	-0.2	-0.2	-0.2	-0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.6	-0.0	-0.6	-0.1	-0.2	-0.8	0.5	0.7	0.3	1.4	1.6
Qualifications: CSEs or equivalent	0.6	0.7	3.0	1.2	-0.4	0.9	1.7	-0.3	0.4	0.2	0.6	-0.7	-1.0
Serious illness, injury or assault to yourself	0.3	0.3	1.2	-0.7	-1.0	-0.5	-1.1	0.5	-0.2	-0.1	-0.2	0.2	0.5
High blood pressure	1.5	4.1	6.7	-2.6	-1.3	-2.3	-2.3	2.1	-2.1	-1.9	-2.4	0.4	1.8
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.8	-0.1	-0.8	-0.7	-0.3	1.2	-0.7	-0.8	-0.6	-1.3	-1.4
Multivitamins +/- minerals	2.4	3.1	5.4	1.1	1.4	1.5	1.4	-2.3	2.0	2.0	1.9	2.1	1.5
Stomach or abdominal pain in last month	0.2	0.3	0.9	-0.3	0.9	-0.3	-0.3	0.3	-0.3	-0.2	-0.4	0.4	0.9
Supplements: Glucosamine	0.1	0.2	0.8	-0.9	-0.4	-0.3	-0.7	0.1	-0.1	-0.1	-0.2	0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	-0.2	-0.5	-0.5	0.1	-0.8	-0.1	-0.0	-0.1	-0.2	-0.0
Medication: Atenolol	1.0	1.2	2.7	-1.2	-0.2	-1.2	-0.8	1.7	-1.3	-1.4	-1.3	-0.8	-0.4
Medication: Levothyroxine sodium	3.7	6.3	9.7	2.9	1.7	3.1	2.8	-3.1	2.8	2.7	2.9	1.2	-0.2
Sitting height	0.1	0.6	2.0	0.7	-0.2	1.4	0.4	-0.9	0.2	-0.0	0.3	-1.0	-1.3
Chronic bronchitis/emphysema (father)	0.4	0.5	2.0	0.5	-1.4	-0.6	0.6	-0.3	0.0	-0.1	0.1	-0.7	-1.2
High blood pressure (mother)	0.5	0.6	0.9	-0.8	0.6	-0.8	-1.0	0.9	-0.8	-0.7	-0.9	0.2	0.9
Body mass index (BMI)	0.3	1.5	8.1	-0.6	1.2	0.4	-0.7	0.3	0.1	0.4	-0.1	2.0	2.9
Impedance of leg (left)	1.6	7.6	18.3	-2.1	-4.3	-3.1	-1.3	2.2	-2.6	-2.7	-2.4	-3.2	-2.7
Leg predicted mass (left)	0.3	1.6	4.0	0.5	1.4	2.0	0.3	-0.9	1.1	1.2	1.0	1.6	1.7
Trunk fat mass	0.4	1.6	3.3	-1.8	-1.0	-0.6	-1.6	1.3	-1.1	-0.9	-1.2	0.5	1.7
Waist circumference	0.4	1.6	7.7	-0.9	-0.0	0.3	-0.4	-0.8	0.7	0.9	0.4	2.2	2.8
Number of incorrect matches in round	0.4	0.7	1.7	-0.7	-0.9	-1.3	-0.7	0.2	-0.9	-0.9	-0.8	-0.9	-0.3
Past tobacco smoking	0.2	0.3	1.2	-0.1	1.1	-0.1	-0.9	0.1	-0.3	-0.2	-0.4	0.5	0.7
Alcohol usually taken with meals	0.6	1.0	2.7	-1.0	-0.9	-1.6	-1.5	0.1	-1.0	-0.9	-1.0	-0.2	0.2
Nervous feelings	2.0	3.6	6.4	2.3	1.6	2.3	2.5	-1.9	2.0	1.7	2.2	-0.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	5.7	8.9	12.0	2.9	3.0	3.2	3.4	-2.9	3.4	3.4	3.5	2.3	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-1.2	-1.1	-1.1	0.1	-0.5	-0.4	-0.4	-0.4	-0.1	-0.2
Hair/balding pattern: Pattern 2	0.2	0.2	1.0	-0.7	-0.0	0.1	-1.0	-0.3	-0.3	-0.2	-0.3	0.1	0.6
Had menopause	3.6	4.5	7.9	-2.8	-1.6	-2.5	-2.6	1.8	-2.4	-2.3	-2.4	-1.2	-0.3
Had other major operations	0.3	0.4	1.0	0.4	0.6	0.1	0.8	-0.2	0.6	0.6	0.6	0.8	1.0
Forced vital capacity (FVC)	0.7	2.6	12.7	0.9	-0.5	0.1	2.0	0.3	-0.2	-0.5	0.2	-2.6	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.1	0.7	-0.3	-0.7	-0.2	0.0	0.1	-0.1	0.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.1	-0.9	-0.1	-0.0	-0.0	-0.4	-0.5	-0.3	-0.8	-0.8
Qualifications: None of the above	1.1	2.4	4.2	-2.1	-0.5	-1.8	-1.9	1.6	-1.8	-1.7	-1.9	-0.7	0.2
Financial difficulties in last 2 years	0.1	0.1	0.2	0.1	-0.5	-0.1	0.3	-0.2	-0.2	-0.2	-0.2	-0.1	0.4
Mouth/teeth dental problems	0.6	0.9	2.9	1.5	0.5	1.7	1.1	-0.1	0.8	0.7	0.9	0.0	-0.5
Heart attack	0.5	0.7	1.3	0.8	0.8	0.2	0.9	-0.4	1.1	1.1	1.1	0.6	0.5
Allergy	0.3	0.6	1.2	0.5	0.7	0.7	0.9	-1.1	0.7	0.7	0.6	1.0	0.9
Pain all over the body in last month	0.4	0.4	1.1	-0.5	-0.6	-1.1	0.8	-0.3	-0.4	-0.4	-0.4	-0.8	-0.6
Diabetes (self-reported)	0.2	0.4	1.2	-0.1	1.1	0.6	-0.4	0.4	-0.0	0.0	-0.1	0.9	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	1.2	1.2	0.8	0.0	-0.6	0.8	0.8	0.8	0.5	0.1
Medication: Ramipril	0.1	0.1	0.6	-0.1	-0.1	-0.5	-0.8	-0.2	-0.0	-0.0	-0.0	0.2	0.3
Medication: Simvastatin	0.2	0.3	1.3	-0.6	-0.9	-1.1	0.1	0.2	-0.3	-0.3	-0.4	0.4	0.3
Fluid intelligence score	0.3	0.6	1.9	-1.0	-1.4	-0.8	-0.6	0.6	-0.6	-0.5	-0.6	-0.6	-0.1
Illnesses of siblings	1.6	2.3	5.0	2.2	1.1	1.8	1.7	-1.6	1.6	1.6	1.7	0.5	-0.0
Neuroticism score	3.9	8.1	14.4	2.9	1.7	3.8	3.0	-2.9	3.4	3.3	3.4	2.0	0.5
Weight	0.1	0.4	2.3	-0.6	0.0	0.7	-0.4	0.2	-0.0	0.0	-0.1	0.9	1.5
Impedance of arm (right)	0.7	3.3	10.5	-2.0	-3.2	-1.8	-1.3	1.6	-1.5	-1.4	-1.4	-1.8	-1.2
Arm fat percentage (right)	0.4	1.5	6.7	-1.6	-0.5	-0.5	-1.2	1.2	-0.4	-0.1	-0.6	1.5	2.6
Trunk fat-free mass	0.1	0.8	2.2	0.7	0.7	1.5	0.8	-1.0	0.9	0.9	1.0	0.6	0.3
Hip circumference	0.2	0.7	2.3	-1.3	-0.4	0.1	-0.9	0.7	-0.6	-0.5	-0.7	0.5	1.5
Time employed in main current job	1.2	1.4	3.0	-0.8	-1.0	-1.0	-1.0	1.7	-1.2	-1.3	-1.1	-1.4	-1.2
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-1.0	-0.0	-0.7	-0.8	0.7	-0.5	-0.4	-0.7	0.2	1.0
Father’s age at death	0.3	0.4	1.5	0.0	0.3	-0.6	0.4	-1.2	0.5	0.5	0.4	0.7	0.6
Worrier / anxious feelings	0.2	0.4	1.3	0.7	0.5	1.1	1.0	-0.1	0.7	0.6	0.7	0.3	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.2	0.1	-0.1	0.4	1.1	-0.9	0.9	0.9	0.9	0.6	0.4
Falls in the last year	2.3	3.2	6.7	1.0	0.9	1.4	1.7	-0.8	2.0	2.2	1.9	2.6	2.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.6	0.5	0.3	0.7	-0.4	0.6	0.6	0.5	0.7	0.5
Number of live births	0.3	0.4	1.3	0.2	-1.2	-0.2	0.5	-1.1	0.3	0.4	0.3	0.4	0.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	10.4	2.2	0.6	1.6	3.2	-0.6	1.2	0.8	1.5	-1.5	-2.8
Pulse rate	2.3	3.9	10.5	1.3	0.7	1.4	0.2	-2.2	2.1	2.3	1.9	3.2	2.6
Happiness	2.8	3.4	5.3	1.9	0.9	1.8	2.3	-1.9	2.3	2.2	2.3	1.5	0.4
Noisy workplace	0.2	0.3	0.8	-0.9	0.2	-0.6	-0.8	0.6	-0.4	-0.3	-0.5	-0.0	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	1.0	0.2	0.8	0.8	-1.1	0.5	0.4	0.6	0.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.7	-0.3	-1.9	-0.9	-0.5	1.4	-1.0	-1.0	-1.0	-1.0	-0.5
Mouth/teeth dental problems: Dentures	0.9	1.5	5.0	-1.4	0.3	-1.4	-2.2	0.8	-1.3	-1.1	-1.4	-0.4	0.5
Asthma	0.2	0.4	1.8	-0.6	-0.2	-1.0	-1.3	0.4	-0.4	-0.3	-0.4	0.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	4.6	-2.1	-0.3	-1.8	-1.8	1.7	-1.8	-1.6	-2.0	-0.3	0.7
Medication: Cholesterol lowering	1.2	1.9	4.8	-2.2	-2.0	-1.8	-0.6	1.3	-1.2	-1.2	-1.2	-0.8	-0.5
Depression (self-reported)	1.9	2.2	5.7	2.3	1.2	1.3	2.4	-1.1	1.4	1.3	1.6	-0.3	-1.0
Medication: Lansoprazole	2.5	2.9	5.9	-2.0	-1.2	-2.4	-1.3	2.2	-1.8	-1.7	-1.9	-0.3	0.9
Prospective memory result	0.4	0.5	1.8	-0.5	-0.9	-1.3	-1.0	-0.0	-0.4	-0.2	-0.5	0.6	0.8
Lung cancer (father)	1.1	1.3	3.5	-1.7	-0.4	-1.1	-1.9	-0.4	-1.3	-1.2	-1.3	-0.6	0.0
Illnesses of mother	0.8	1.0	2.0	1.1	0.4	0.8	1.0	-0.7	1.4	1.3	1.4	1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.2	1.7	1.3	1.2	2.3	-0.6	1.1	0.8	1.3	-0.8	-1.8
Pulse wave Arterial Stiffness index	1.1	1.3	4.4	-1.3	-0.7	-1.3	-1.5	0.5	-0.4	-0.3	-0.6	1.3	2.1
Impedance of arm (left)	0.9	4.0	11.3	-1.9	-3.4	-1.8	-1.1	1.9	-1.7	-1.7	-1.6	-2.3	-1.8
Arm fat mass (right)	0.2	1.0	5.7	-0.9	0.2	0.3	-0.7	0.6	0.0	0.2	-0.2	1.5	2.4
Trunk predicted mass	0.1	0.8	2.1	0.8	0.6	1.4	0.8	-1.0	0.9	0.8	1.0	0.5	0.3
Standing height	0.2	1.6	5.8	-0.3	-2.4	0.6	0.4	-0.1	-0.3	-0.6	-0.1	-2.0	-2.4
Length of working week for main job	0.2	0.2	1.1	1.0	0.6	0.5	0.0	0.0	0.4	0.3	0.4	0.1	0.1
Exposure to tobacco smoke at home	1.3	1.5	3.3	1.1	-0.1	1.3	1.8	-1.1	1.4	1.5	1.3	1.2	0.7
Breastfed as a baby	0.5	0.6	2.5	0.4	-0.2	0.2	1.3	0.0	0.1	-0.1	0.2	-1.1	-1.6
Tense / ‘highly strung’	1.0	1.7	2.9	1.3	0.3	1.6	1.3	-1.3	1.6	1.5	1.7	0.3	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	5.3	-1.3	-2.1	-0.4	0.5	1.1	-1.4	-1.6	-1.2	-2.3	-1.9
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	-1.1	-0.6	-1.1	-1.2	1.1	-0.7	-0.7	-0.8	-0.4	0.1
Birth weight of first child	1.0	1.9	5.6	-0.1	1.6	0.4	-0.5	-1.4	1.1	1.2	0.9	2.4	2.2
Peak expiratory flow (PEF)	0.5	1.2	3.5	0.7	-0.7	1.1	1.9	-0.3	0.7	0.5	0.9	-0.9	-1.8
Pulse wave reflection index	0.4	0.5	1.4	-0.8	-1.0	-1.2	0.2	1.0	-0.4	-0.4	-0.5	-0.2	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.5	-0.1	0.3	-0.0	-0.0	0.3	0.3	0.3	0.1	-0.3
Loud music exposure frequency	0.3	0.4	2.2	-0.0	-0.8	0.0	-0.1	0.1	-0.0	-0.2	0.0	-0.9	-1.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	1.1	0.1	1.0	1.5	-0.3	1.0	0.9	1.1	0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.3	-1.1	-0.7	-1.5	-1.0	0.6	-0.8	-0.8	-0.8	-0.4	-0.3
Blood clot in the leg (DVT)	3.1	4.1	7.3	-2.1	-1.7	-2.2	-2.5	2.7	-2.1	-2.0	-2.1	-1.4	-0.3
Medication: Paracetamol	0.3	0.5	1.6	0.4	1.0	-0.5	0.5	0.2	0.3	0.4	0.3	1.2	1.2
Headache pain in last month	0.8	1.3	4.2	-1.4	0.4	-1.2	-1.1	0.5	-0.9	-0.7	-1.1	1.2	2.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.2	2.5	1.2	1.6	1.0	-1.1	1.1	0.9	1.2	-0.4	-1.2
Glaucoma (self-reported)	0.4	0.5	1.3	1.1	1.1	0.0	-0.0	0.6	-0.1	-0.2	0.0	-1.0	-1.1
Gout (self-reported)	2.7	3.7	6.0	-2.0	-1.0	-1.8	-1.3	2.5	-2.4	-2.4	-2.4	-1.8	-0.8
Hypothyroidism/myxoedema (self-reported)	8.1	15.9	27.1	4.5	3.2	5.2	4.1	-4.8	4.3	4.2	4.5	2.0	0.1
Medication: Amlodipine	1.0	1.4	8.4	0.7	2.9	0.9	0.3	-0.5	0.5	0.6	0.5	1.3	1.4
Medication: Ventolin 100micrograms inhaler	1.3	1.7	4.5	-1.3	-0.7	-1.5	-0.6	2.1	-1.4	-1.5	-1.5	-1.1	-0.6
Birth weight	2.0	4.3	8.9	0.8	2.1	1.9	0.6	-2.5	2.1	2.2	1.9	3.0	2.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.6	0.5	-0.5	0.4	-0.4	-0.3	-0.3	-0.2	-0.5	-0.5
High blood pressure (siblings)	2.3	3.3	5.9	-2.2	-1.3	-2.4	-1.9	1.5	-2.0	-2.1	-2.1	-1.2	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	6.9	0.8	0.3	0.3	1.8	0.0	0.2	-0.1	0.4	-1.9	-2.6
Body fat percentage	0.6	2.4	4.8	-2.2	-1.4	-1.2	-2.0	1.7	-1.4	-1.2	-1.6	0.5	1.8
Leg fat percentage (right)	1.1	4.0	7.4	-2.7	-1.9	-2.2	-2.2	1.9	-2.2	-2.0	-2.3	-0.5	1.0
Arm fat-free mass (right)	0.1	0.7	2.1	0.6	1.0	1.4	0.2	-0.5	0.7	0.6	0.6	1.0	0.9
Exposure to tobacco smoke outside home	1.0	1.3	2.6	0.5	0.5	1.5	1.6	-1.5	1.2	1.2	1.2	0.8	0.4
Comparative body size at age 10	0.6	1.7	3.3	1.3	1.8	1.7	1.4	-0.6	1.5	1.4	1.6	0.7	0.1
Number of full brothers	0.4	0.6	1.7	-1.2	-1.0	-0.2	0.2	1.3	-0.7	-0.7	-0.7	-0.2	-0.1
Worry too long after embarrassment	0.2	0.4	1.4	1.0	0.6	1.2	0.0	0.0	0.5	0.5	0.6	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	0.8	-0.1	0.5	0.9	-0.4	0.7	0.6	0.9	-0.5	-1.4
Wheeze or whistling in the chest in last year	0.5	0.9	2.6	-1.6	-0.2	-0.7	-1.3	-0.9	-0.2	-0.0	-0.4	0.9	1.6
Number of children fathered	0.6	0.7	1.5	0.2	0.6	-0.9	-0.0	1.1	-0.8	-0.9	-0.7	-1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.9	0.2	2.0	0.3	1.4	-0.2	0.4	0.4	0.5	0.8	0.7
Age at first live birth	1.8	3.1	5.7	2.2	2.3	2.1	1.1	-2.4	1.8	1.7	1.8	0.7	-0.2
Pulse wave peak to peak time	1.1	1.3	5.4	1.0	0.2	1.2	1.4	-0.3	0.2	0.1	0.4	-1.6	-2.3
Health satisfaction	0.2	0.3	0.7	-0.0	-0.7	-0.2	0.8	-0.1	0.6	0.6	0.6	0.4	0.5
Shortness of breath walking on level ground	0.3	0.3	1.1	0.4	-0.5	0.2	1.0	0.1	0.3	0.2	0.5	-0.5	-1.1
Qualifications: College or University degree	0.2	0.7	3.1	1.3	1.8	0.6	0.3	0.0	0.7	0.6	0.8	0.1	-0.5
Eye problems/disorders: None of the above	1.1	1.3	5.0	0.3	-1.7	0.1	0.6	-0.7	-0.5	-0.7	-0.4	-1.7	-2.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.1	-0.2	0.5	0.3	0.5	0.4	0.3	0.4	0.3	-0.3
Emphysema/chronic bronchitis	1.0	1.1	3.4	-1.8	-0.3	-1.1	-1.0	0.7	-1.2	-1.0	-1.3	0.4	1.1
Medication for pain relief, constipation, heartburn	1.7	2.9	5.3	2.3	0.1	2.3	2.1	-1.4	1.5	1.2	1.8	-1.0	-2.1
Neck or shoulder pain in last month	0.7	1.0	2.1	0.2	0.3	0.1	1.0	-1.4	0.9	1.0	0.8	1.4	1.4
Medication: Blood pressure	1.6	2.8	8.0	-2.8	-0.7	-1.8	-1.4	1.8	-1.6	-1.4	-1.8	0.5	1.7
Angina (self-reported)	1.1	1.5	2.2	1.2	1.1	1.0	1.3	-1.3	1.4	1.5	1.5	0.9	0.5
Migraine (self-reported)	0.7	0.9	2.0	0.3	1.3	0.6	0.4	-1.4	0.6	0.6	0.4	1.3	1.4
Medication: Ibuprofen	2.1	2.5	4.7	-2.1	-0.6	-2.2	-1.4	1.6	-1.8	-1.7	-2.0	-0.4	0.6
Medication: Allopurinol	5.1	6.8	11.8	-3.4	-1.4	-3.1	-2.2	2.7	-3.1	-3.1	-3.2	-1.6	-0.3
Medication: Omeprazole	0.1	0.2	0.6	0.3	0.4	-0.1	0.1	-0.8	0.4	0.4	0.4	0.3	0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-0.4	1.0	-0.5	-0.2	-0.0	0.5	0.6	0.4	1.1	1.1
Mean time to correctly identify matches	0.8	1.5	2.7	1.1	-0.4	0.3	1.6	-1.6	1.6	1.6	1.6	0.9	-0.1
Heart disease (mother)	1.3	1.6	3.1	-0.8	-0.5	-1.6	-0.8	1.8	-1.3	-1.4	-1.3	-1.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	3.7	0.9	1.1	1.3	1.1	-1.5	1.7	1.9	1.6	1.9	1.6
Whole body fat mass	0.3	1.2	4.1	-1.6	-0.6	-0.3	-1.2	0.9	-0.7	-0.5	-0.9	1.0	2.0
Leg fat mass (right)	0.3	1.3	3.0	-1.7	-0.6	-0.7	-1.4	1.0	-1.1	-1.0	-1.3	0.4	1.6
Arm predicted mass (right)	0.1	0.5	1.6	0.6	1.0	1.3	0.2	-0.5	0.5	0.5	0.5	0.7	0.7
Pulse rate, automated reading	1.5	5.0	12.0	1.2	1.8	1.9	0.3	-2.7	2.1	2.4	1.9	3.5	2.9
Alcohol intake frequency.	0.4	0.9	1.9	-0.7	-0.1	-1.1	-1.4	1.4	-1.0	-0.9	-1.1	-0.7	-0.3
Comparative height size at age 10	0.2	1.3	3.9	1.0	-0.5	1.3	1.1	-1.4	0.9	0.5	1.1	-1.1	-2.0
Number of full sisters	3.1	3.7	5.2	-2.3	-2.1	-2.3	-1.6	2.2	-2.0	-2.0	-2.0	-1.6	-0.7
Suffer from ‘nerves’	0.6	1.0	2.2	1.3	0.5	0.9	1.2	-1.5	0.9	0.8	1.0	-0.2	-1.1
Overall health rating	0.8	1.7	7.2	-0.8	0.2	-0.2	0.5	-1.4	0.8	1.1	0.6	2.1	2.7
Chest pain or discomfort	0.9	1.3	4.3	-2.0	-2.1	-0.8	-0.8	0.4	-0.9	-0.9	-1.0	-0.3	0.4
Had major operations	5.3	6.2	8.8	-2.4	-2.6	-3.0	-2.1	2.3	-2.8	-2.9	-2.7	-2.5	-1.5
Age at last live birth	2.1	3.0	7.8	2.1	2.8	2.3	0.4	-2.1	1.4	1.4	1.4	1.3	0.6
Family relationship satisfaction	0.4	0.6	1.8	0.4	-1.3	0.2	0.6	-0.6	0.6	0.5	0.7	-0.5	-1.2
Leg pain on walking	0.2	0.3	1.4	-0.2	-1.2	-1.0	0.5	0.2	-0.1	-0.1	-0.0	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	6.6	1.4	1.1	2.6	1.4	-1.5	2.5	2.5	2.4	2.2	1.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.5	0.4	-0.1	-0.6	0.7	0.6	0.0	-0.0	-0.0	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	1.2	1.7	1.2	1.0	-1.5	1.4	1.3	1.4	0.4	-0.7
Medication: Aspirin	2.1	2.7	6.9	-2.6	-1.1	-2.0	-2.4	1.0	-1.4	-1.3	-1.6	0.4	1.3
Supplements: Vitamin C	1.4	1.6	4.0	2.0	0.9	2.0	1.3	-1.1	0.9	0.8	1.1	-0.5	-1.3
Knee pain experienced in last month	0.2	0.3	1.1	-0.0	-1.0	-0.7	0.3	0.1	0.1	0.1	0.0	0.6	0.9
Hypertension (Self-reported)	1.2	3.4	5.7	-2.4	-1.1	-2.0	-1.9	2.0	-2.0	-1.8	-2.2	0.4	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	-0.1	0.2	-0.5	-1.0	-0.1	0.0	0.2	-0.0	0.5	0.8
Illnesses of father: Heart disease	1.5	2.1	3.9	2.0	1.1	1.7	1.7	-1.4	1.5	1.4	1.6	0.1	-0.9
Illnesses of siblings: Diabetes	0.8	1.0	3.7	-0.9	0.6	-0.7	-1.4	-0.1	0.1	0.3	-0.2	1.5	1.9
Smoking status: Previous	0.1	0.1	0.6	-0.3	-0.7	-0.3	0.3	0.2	0.1	0.1	0.1	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.4	-0.0	-0.6	0.1	0.0	0.4	0.1	0.1	0.1	-0.0	0.1
Whole body fat-free mass	0.2	1.4	3.5	0.9	1.1	1.9	0.7	-1.1	1.2	1.2	1.2	1.2	1.1
Leg fat-free mass (right)	0.5	2.5	5.6	1.1	1.7	2.4	0.7	-0.9	1.6	1.6	1.5	1.9	1.7
Arm fat percentage (left)	0.4	1.6	5.5	-1.7	-0.6	-0.6	-1.4	1.5	-0.7	-0.5	-0.9	1.2	2.4
Average weekly red wine intake	0.4	0.6	1.1	0.7	0.6	0.6	0.5	-0.7	1.0	0.9	1.1	0.7	-0.2
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.8	-1.8	-1.4	-2.2	-1.4	1.6	-1.7	-1.5	-1.7	-0.8	0.4
Mood swings	1.3	2.4	5.1	1.2	1.3	2.3	1.5	-1.4	1.6	1.7	1.6	1.4	1.2
Loneliness, isolation	3.0	4.2	8.4	2.9	0.9	2.2	2.6	-2.0	2.3	2.2	2.5	0.8	-0.6
Long-standing illness, disability or infirmity	0.4	0.7	2.2	-1.5	-0.7	-1.0	-0.3	0.6	-0.7	-0.6	-0.8	0.2	0.9
Ever had bowel cancer screening	0.7	0.8	2.9	-1.2	-1.7	-1.7	-0.7	0.1	-0.4	-0.3	-0.5	-0.1	0.1
Diabetes diagnosed by doctor	0.7	1.1	3.1	-0.9	0.9	-0.1	-1.8	1.1	-0.5	-0.3	-0.7	1.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	-0.5	-0.4	-0.5	-0.7	-0.4	0.4	0.6	0.3	1.1	1.1
Friendships satisfaction	2.8	3.4	7.1	2.7	0.9	1.4	2.5	-2.0	2.1	1.9	2.2	0.4	-1.1
Qualifications: nursing, teaching	0.3	0.4	1.2	1.0	1.1	0.7	0.9	-0.3	0.3	0.3	0.4	-0.1	-0.1
Commuting to job workplace: Walk	1.1	1.2	2.7	0.9	1.0	1.6	0.0	-1.0	1.3	1.3	1.3	0.9	0.4
Eye problems/disorders: Cataract	1.0	1.1	4.8	0.1	2.2	0.1	0.2	0.5	0.6	0.8	0.6	1.5	1.6
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	4.6	0.7	-0.5	0.3	1.8	-2.1	1.6	1.7	1.5	1.5	1.2
Medication for cholesterol	0.2	0.3	1.0	0.1	-0.6	0.6	0.4	-0.3	-0.0	-0.1	0.0	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.7	-0.9	-0.0	-0.7	0.1	-0.6	-0.2	-0.0	-0.3	1.2	1.7
Back pain experienced in last month	0.4	0.6	2.3	-1.0	0.0	-0.6	-0.7	-0.1	0.3	0.5	0.2	1.3	1.5
Mineral and other dietary supplements	0.9	1.2	2.3	1.5	0.2	0.8	0.4	-0.3	1.4	1.5	1.3	1.4	1.2
Breast cancer (self-reported)	1.5	1.8	7.2	-0.2	-2.7	-0.8	0.3	0.1	-0.4	-0.6	-0.2	-2.0	-2.2
Asthma (self-reported)	0.3	0.5	1.7	-0.7	-0.6	-1.2	-1.3	0.5	-0.5	-0.5	-0.6	-0.2	0.2
Osteoporosis (self-reported)	0.5	0.6	1.5	-0.0	-1.0	1.2	0.6	-0.7	0.7	0.7	0.7	0.7	0.7
Osteoarthritis (self-reported)	0.7	0.9	2.5	0.4	0.5	0.1	0.5	-0.5	1.0	1.2	0.9	1.5	1.6
Medication: Aspirin	1.9	2.4	6.6	-2.6	-0.9	-1.8	-2.1	1.1	-1.4	-1.3	-1.6	0.5	1.4
Medication: Gliclazide	1.3	1.4	3.8	0.6	2.0	1.1	0.1	-0.7	1.0	1.0	0.9	1.8	1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-0.7	0.4	-0.8	-1.1	0.9	-0.9	-0.8	-0.9	-0.2	0.7
Smoking status: Current	0.1	0.1	0.5	0.1	-0.1	0.3	-0.2	-0.7	-0.0	-0.0	0.1	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.5	0.9	0.9	0.3	0.5	-0.0	0.2	-0.0	0.3	-1.1	-1.6
Whole body water mass	0.2	1.4	3.4	0.8	1.1	1.9	0.6	-1.1	1.2	1.2	1.2	1.3	1.1
Leg predicted mass (right)	0.5	2.4	5.6	1.0	1.7	2.4	0.7	-0.9	1.5	1.6	1.4	1.9	1.8
Arm fat mass (left)	0.2	1.0	5.0	-1.2	-0.0	0.0	-1.0	0.9	-0.3	-0.1	-0.5	1.2	2.2
Number of self-reported non-cancer illnesses	0.3	0.5	2.6	-0.4	-0.0	-0.2	-0.2	0.0	0.4	0.5	0.3	1.4	1.6
Average weekly champagne plus white wine intake	0.5	0.7	2.8	1.1	1.7	0.6	0.7	-0.7	0.6	0.6	0.7	0.4	0.1
Miserableness	1.3	2.3	4.6	0.3	-0.7	2.1	1.6	-1.5	1.6	1.8	1.6	1.8	1.5
Guilty feelings	3.8	5.7	10.6	2.6	1.3	3.3	2.2	-2.0	2.9	2.9	2.9	1.7	0.8
Wears glasses or contact lenses	0.7	0.8	1.8	-1.3	-1.2	-0.8	-1.4	0.1	-0.8	-0.8	-0.9	-0.5	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.3	-0.1	0.6	0.4	-0.4	0.6	0.6	0.6	0.4	0.3
Hearing aid user	1.6	1.8	3.5	-1.9	0.6	-1.6	-1.7	0.3	-1.5	-1.3	-1.6	0.3	1.5
Mother’s age at death	5.0	6.3	9.9	2.0	2.7	3.0	1.4	-3.1	2.6	2.7	2.6	2.5	1.8
Financial situation satisfaction	0.7	0.8	3.3	0.8	-0.3	0.6	1.8	-0.8	1.0	0.9	1.0	0.7	0.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	-1.5	-0.9	-1.2	-1.2	-0.1	-0.9	-0.8	-1.1	0.6	1.1
Commuting to job workplace: Public transport	1.0	1.2	2.0	0.7	0.6	1.4	0.8	-1.0	1.3	1.3	1.2	1.4	0.9
Eye problems/disorders: Glaucoma	2.5	3.0	8.1	2.9	2.5	1.7	2.0	-0.4	1.6	1.5	1.8	0.1	-0.6
Medication: Blood pressure	0.6	1.1	3.3	-0.7	-0.1	-1.8	-1.5	0.7	-1.0	-0.9	-1.1	0.5	1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.2	0.6	0.9	0.6	-0.6	0.5	0.6	0.5	1.0	1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	-1.1	-0.5	-0.6	0.6	0.1	-0.6	-0.6	-0.5	-0.8	-0.5
High cholesterol (Self-reported)	0.6	1.1	2.7	-1.3	-1.6	-1.6	-0.4	1.4	-0.7	-0.7	-0.7	-0.0	0.2
Medication: Bendroflumethiazide	2.1	3.2	7.9	-2.6	0.1	-2.2	-2.1	0.3	-1.4	-1.1	-1.7	1.6	2.8
Medication: Paracetamol	0.2	0.3	1.2	0.5	0.8	-0.5	1.1	0.3	0.3	0.3	0.3	0.6	0.5
Medication: Lisinopril	4.4	5.7	10.0	-3.2	-2.9	-2.8	-1.9	2.4	-2.6	-2.5	-2.7	-0.4	0.6
Medication: Atorvastatin	0.1	0.1	0.6	-0.3	0.8	0.3	-0.3	0.3	-0.0	0.0	-0.0	-0.0	0.4
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.2	0.8	0.0	-0.3	-0.6	0.5	0.5	0.4	1.0	0.9
Alcohol drinker status: Never	0.7	0.9	2.8	-0.2	1.7	-0.3	-1.0	0.4	-0.1	0.2	-0.3	1.3	1.7
Ever smoked	0.2	0.3	1.1	-0.4	-1.0	-0.1	0.6	-0.0	0.0	-0.1	0.1	-0.9	-1.0
Basal metabolic rate	0.2	0.9	2.7	0.5	0.8	1.6	0.4	-0.7	0.9	0.9	0.8	1.1	1.1
Leg fat percentage (left)	0.9	3.3	6.2	-2.5	-1.6	-2.0	-2.0	2.0	-1.9	-1.7	-2.1	-0.0	1.3
Arm fat-free mass (left)	0.2	0.9	2.3	0.5	0.8	1.5	0.4	-0.8	0.8	0.8	0.8	1.1	1.1
Number of operations (self-reported)	3.2	4.7	7.9	-2.6	-1.4	-2.7	-2.8	1.7	-2.5	-2.5	-2.5	-1.2	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.4	0.1	0.7	-0.2	-0.0	0.2	0.2	0.2	0.3	0.1
Irritability	2.0	3.3	8.1	1.4	1.8	2.8	1.1	-1.4	2.0	2.0	2.0	1.7	1.2
Risk taking	0.7	1.0	4.5	-0.8	-0.0	-0.2	-1.0	-0.5	0.5	0.7	0.3	1.7	2.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.2	-1.1	-1.1	-0.9	-0.1	-0.0	-0.5	-0.4	-0.5	0.1	0.5
Fractured/broken bones in last 5 years	1.2	1.5	4.2	-2.1	-0.7	-0.9	-1.9	0.4	-0.6	-0.4	-0.8	1.1	1.9
Age started oral contraceptive pill	0.2	0.2	0.5	0.7	0.7	0.6	0.1	-0.2	0.4	0.3	0.4	-0.1	-0.5
Diastolic blood pressure, automated reading	1.0	3.1	7.1	-2.2	-0.8	-1.6	-1.2	2.7	-2.1	-2.1	-2.1	-1.2	-0.4
Ever depressed for a whole week	2.0	2.5	4.2	-1.1	-1.5	-1.2	-1.3	1.5	-2.0	-2.0	-1.8	-1.8	-1.1
Unable to work because of sickness or disability	0.6	0.7	2.5	0.8	0.5	1.0	1.6	-0.2	0.9	0.9	1.0	-0.2	-0.6
Commuting to job workplace: Cycle	0.8	0.9	3.1	-0.0	-0.7	0.1	-0.2	0.6	-1.1	-1.2	-0.9	-1.8	-1.4
Myopia	0.2	0.3	1.4	-0.6	-1.0	0.2	0.1	-0.0	0.1	0.0	0.3	-0.7	-1.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.5	2.1	0.8	1.9	1.9	-1.6	1.5	1.3	1.7	-0.6	-1.7
Cholesterol lowering medication	0.6	0.8	3.2	-0.7	0.8	-0.9	-1.1	0.4	-0.3	-0.2	-0.4	1.3	1.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.1	0.3	0.0	-0.0	-0.6	0.2	0.2	0.2	-0.0	0.1
Pain experienced in last month	0.8	1.3	5.4	0.5	-0.7	0.1	-0.2	0.9	-0.7	-0.9	-0.4	-2.1	-2.3
Supplements: Calcium	0.2	0.2	0.6	-0.0	-0.4	0.8	0.5	-0.5	0.6	0.5	0.6	0.3	0.3
Basal cell carcinoma (self-reported)	0.2	0.3	1.1	-0.5	0.4	-0.4	-0.8	0.4	0.1	0.2	-0.1	0.6	1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.9	1.1	0.9	0.5	1.1	-0.6	1.4	1.4	1.4	0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	3.3	4.3	6.9	-2.0	-1.8	-2.2	-2.6	2.6	-2.2	-2.1	-2.2	-1.6	-0.6
Heart disease (siblings)	0.1	0.1	0.5	0.1	0.1	0.1	0.4	0.1	-0.1	-0.2	-0.1	-0.5	-0.7
Alcohol drinker status: Previous	0.9	1.0	3.6	0.1	-0.5	-0.5	-0.5	0.9	-0.8	-0.9	-0.7	-1.7	-1.9
Pack years of smoking	0.7	1.1	2.3	-1.2	-0.2	-1.5	-1.5	1.1	-0.8	-0.5	-1.0	0.6	1.1
Impedance of whole body	1.3	6.7	17.1	-2.1	-4.1	-2.6	-1.3	2.4	-2.3	-2.4	-2.2	-3.0	-2.6
Leg fat mass (left)	0.3	1.3	3.2	-1.7	-0.5	-0.6	-1.3	1.1	-1.0	-0.8	-1.2	0.6	1.8
Arm predicted mass (left)	0.1	0.7	1.8	0.5	0.8	1.4	0.2	-0.5	0.7	0.7	0.6	1.1	1.1