Hub : Genes

SRSF10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.3510 0.0760 3.1e-06 0.164 NA 0.216 NA 0.227 2.2e-09 NA 4.0e-12 NA 1.0e-12
2 METSIM Adipose 0.0514 0.0204 8.2e-04 0.021 0.018 0.018 0.018 0.005 3.1e-04 9.0e-04 9.6e-04 7.8e-04 4.8e-02
3 ROSMAP Brain Pre-frontal Cortex 0.0998 0.0331 4.2e-06 0.054 0.049 0.063 0.055 0.061 1.6e-07 6.6e-07 1.7e-08 1.2e-07 2.4e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.3 -0.3 -0.5 -0.6
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 -0.2 0.0 -0.5
Depressed Affect (Nagel 2018) 0.2 0.5 0.8 0.2 -0.9 0.9
Depression (Nagel 2018) 0.1 0.2 0.3 -0.6 0.0 0.4
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.7 -0.5 1.6 -1.0
Neuroticism (Nagel 2018) 0.2 0.5 1.3 -0.5 -0.2 1.2
Schizophrenia (2018) 0.0 0.1 0.1 -0.0 0.4 -0.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.4 0.2 -0.2
Worry (Nagel 2018) 0.1 0.3 0.6 -0.5 0.0 0.8
Alzheimer’s Disease (in mother) 3.0 3.5 5.7 1.8 -1.3 2.4
Alzheimer’s Disease (in father) 0.3 0.4 0.8 -0.9 0.4 0.4
Alzheimer’s Disease (including proxy) 2.0 2.9 4.1 1.4 -1.6 2.0
Crohns Disease (2017) 0.2 0.4 1.1 -0.4 1.0 -0.2
Irritable Bowel Disease (IBD) 0.8 1.9 2.6 -1.6 1.4 -1.0
Ulcerative Colitis (UC) 0.6 1.2 2.1 -1.4 0.9 -0.8
Major Depression (MDD) 0.0 0.0 0.1 -0.2 0.1 0.3
Reaction Time 0.5 0.9 2.5 -0.5 -1.6 0.0
Verbal and Numeric Reasoning (VNR) 2.1 5.1 7.1 -1.6 2.3 -2.7
Breast Cancer 0.6 1.6 2.7 1.6 -1.4 0.4
Ovarian Cancer 2.3 3.0 5.6 -1.0 2.4 -1.6
Prostate Cancer 2.0 2.8 3.9 -1.0 2.0 -1.9
Age at First Birth 2.2 3.2 5.8 2.4 -1.1 1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 0.8 -0.6 -0.3
Coronary Artery Disease (CAD) 0.3 0.3 0.6 0.6 -0.7 0.0
Crohns Disease (2012) 1.5 2.4 4.5 -1.3 2.1 -0.9
Mean Putamen Volume 1.4 1.6 2.7 1.4 -0.3 1.6
Fasting Glucose 1.0 1.2 1.8 0.9 -1.0 1.3
HbA1C 1.7 1.9 2.1 -1.5 1.2 -1.5
HDL Cholesterol 0.1 0.1 0.2 0.1 0.5 0.1
LDL Cholesterol 0.1 0.1 0.1 -0.2 0.3 -0.4
Lupus 1.8 2.7 4.5 2.1 -1.7 0.8
Neuroticism (2016) 0.3 0.4 0.5 0.3 -0.7 0.7
Primary Biliary Cirrhosis 0.3 0.5 0.6 -0.8 0.6 -0.6
Rheumatoid Arthritis 0.6 0.9 1.5 -0.7 1.2 -0.7
Schizophrenia (2014) 0.0 0.0 0.0 -0.2 0.2 -0.2
Triglycerides 5.8 9.5 14.4 3.1 -3.8 2.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.1 1.0 -0.1 0.9
Ulcerative Colitis 0.7 1.1 2.2 -1.5 0.5 -0.9
Blood Eosinophil Count 3.4 26.1 35.9 -3.2 5.7 -6.0
Blood Platelet Count 0.5 6.4 12.8 3.6 -2.1 1.3
Blood Red Count 0.9 9.1 13.8 -2.1 3.0 -3.7
Blood White Count 0.7 5.4 10.6 3.3 -2.2 0.7
Heel T-Score 0.5 4.3 5.2 -2.2 1.7 -2.3
BMI 0.3 1.9 3.2 1.0 -1.8 1.2
Height 0.1 1.5 2.4 -1.4 1.5 0.4
Waist Hip Ratio (WHR) 0.2 0.7 1.5 -1.2 0.8 -0.2
Systolic Blood Pressure 0.6 3.2 6.2 -0.5 2.5 -1.8
Smoking Status 1.0 2.3 4.7 -2.2 1.1 -1.0
Allergy or Eczema 0.1 0.3 0.6 0.1 0.5 -0.7
Cardiovascular Disease 0.4 1.4 3.4 -0.6 1.8 -0.6
Hypothyroidism (self reported) 3.0 7.0 11.0 0.2 -3.3 3.1
Respiratory disease 0.2 0.5 0.8 0.9 0.7 0.1
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.4 1.0 -0.1 1.6
Lung FEV1/FVC ratio 0.3 1.7 2.7 0.9 -1.6 1.2
Lung FVC 0.6 3.0 8.0 2.8 -0.4 0.9
Neuroticism 0.2 0.5 1.0 -0.3 -0.6 1.0
Chronotype (morning person) 0.8 1.8 4.3 2.1 -0.9 0.6
Hair Pigment 0.1 3.1 5.1 0.7 -2.2 2.0
Tanning 0.2 1.9 3.6 -1.2 0.8 -1.9
Hand grip strength (left) 2.2 5.8 6.3 2.4 -2.5 2.3
Number of treatments/medications taken 1.1 1.9 5.0 -0.6 2.2 -0.6
Average weekly spirits intake 0.7 0.9 2.5 -0.1 0.4 -1.6
Sensitivity / hurt feelings 1.4 2.5 4.9 0.7 -1.4 2.2
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.1 -0.9 1.1 0.3
Hearing difficulty/problems: Yes 0.3 0.5 0.9 0.9 -0.8 -0.1
Relative age of first facial hair 0.2 0.4 1.3 0.0 -1.1 0.0
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.5 -0.8 1.2 -0.3
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 -0.3 -0.6 0.7
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.2 0.4 -0.6
Systolic blood pressure, automated reading 0.4 1.1 2.2 -0.5 1.0 -1.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.5 -0.7 0.2 0.6
Angina 0.1 0.1 0.3 -0.1 0.0 0.6
Medication for hormone replacement therapy 0.1 0.2 0.4 -0.3 -0.2 0.6
Vitamin and mineral supplements 0.2 0.3 0.8 0.9 -0.1 0.4
Supplements: Zinc 0.1 0.1 0.3 0.4 -0.1 0.6
Medication: Co-codamol 1.3 1.6 3.0 -1.1 0.7 -1.7
Medication: Metformin 0.5 0.7 1.0 1.0 0.4 0.9
Diabetes (father) 0.2 0.3 0.7 0.0 0.9 0.2
Diabetes (mother) 0.6 0.8 1.7 1.3 0.6 0.4
Severe depression (siblings) 2.2 2.5 3.9 -1.7 0.9 -2.0
Pack years adult smoking proportion 0.1 0.1 0.3 0.5 0.1 -0.0
Impedance of leg (right) 3.6 17.5 18.8 -4.3 4.0 -4.2
Leg fat-free mass (left) 0.4 2.0 2.7 0.9 -1.5 1.6
Trunk fat percentage 0.7 2.9 5.5 -2.3 0.8 -1.6
Hand grip strength (right) 2.9 7.9 9.4 3.1 -2.8 2.6
Townsend deprivation index at recruitment 0.2 0.3 0.8 -0.9 0.1 0.1
Current tobacco smoking 0.1 0.1 0.2 -0.4 -0.2 0.4
Average weekly fortified wine intake 6.7 7.8 12.5 -3.5 2.3 -2.4
Maternal smoking around birth 0.2 0.3 0.5 0.7 -0.6 0.2
Fed-up feelings 0.7 1.3 2.8 0.4 -0.9 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.2 -0.5 0.4
Relative age voice broke 0.1 0.1 0.4 -0.1 -0.3 0.6
Taking other prescription medications 2.2 3.4 7.3 -1.6 2.7 -0.5
Age when periods started (menarche) 1.0 2.4 4.1 -0.2 -1.8 2.0
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.2 -0.4 1.1 -1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.0 1.4 -0.2 1.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.4 -0.3 -0.0
Qualifications: CSEs or equivalent 1.2 1.6 2.5 -1.6 1.0 -1.1
Serious illness, injury or assault to yourself 0.5 0.5 1.2 -1.1 0.6 -0.4
High blood pressure 0.6 1.7 4.5 -0.6 2.1 -0.3
Hayfever, allergic rhinitis or eczema 0.2 0.3 0.6 0.3 0.8 -0.6
Multivitamins +/- minerals 0.8 1.0 1.6 0.7 -1.3 1.0
Stomach or abdominal pain in last month 0.7 0.9 1.4 1.2 -0.5 1.1
Supplements: Glucosamine 0.2 0.2 0.4 -0.6 -0.0 -0.6
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.1 -0.9 1.1 -0.9
Medication: Atenolol 0.1 0.2 0.4 0.2 0.4 -0.6
Medication: Levothyroxine sodium 0.8 1.4 3.0 0.0 -1.0 1.7
Sitting height 0.1 0.5 1.3 -0.4 -0.1 1.1
Chronic bronchitis/emphysema (father) 1.6 1.9 3.0 -1.7 0.2 -1.6
High blood pressure (mother) 0.1 0.1 0.3 0.5 0.4 -0.1
Body mass index (BMI) 0.3 1.4 2.7 0.7 -1.6 0.9
Impedance of leg (left) 3.0 14.5 17.3 -4.2 3.3 -3.9
Leg predicted mass (left) 0.4 2.2 3.2 0.9 -1.6 1.8
Trunk fat mass 0.3 1.1 2.6 -1.6 0.4 -0.8
Waist circumference 0.2 0.6 1.6 -1.3 0.0 -0.4
Number of incorrect matches in round 0.3 0.5 1.3 -0.5 0.2 -1.1
Past tobacco smoking 2.1 3.8 6.1 2.5 -1.4 1.8
Alcohol usually taken with meals 1.6 2.6 3.4 -1.1 1.8 -1.8
Nervous feelings 0.2 0.4 1.1 -0.1 -0.1 1.1
Frequency of tenseness / restlessness in last 2 weeks 2.8 4.3 8.9 1.3 -1.6 3.0
Hearing difficulty/problems with background noise 0.5 0.8 1.1 -1.1 -0.3 -1.0
Hair/balding pattern: Pattern 2 0.2 0.2 0.5 0.1 0.7 0.4
Had menopause 1.0 1.3 2.3 -0.3 1.5 -1.2
Had other major operations 0.0 0.0 0.0 -0.1 -0.0 0.1
Forced vital capacity (FVC) 0.1 0.3 0.8 0.0 0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.5 1.2 -0.1 1.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.8 -1.3 0.3 -1.0
Qualifications: None of the above 0.1 0.2 0.5 -0.2 0.2 -0.7
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.4 0.2 -0.2
Mouth/teeth dental problems 1.0 1.5 3.3 0.5 -1.8 1.0
Heart attack 0.3 0.3 0.5 -0.7 0.7 -0.3
Allergy 0.1 0.3 0.5 -0.7 -0.6 -0.1
Pain all over the body in last month 0.6 0.6 0.8 -0.7 0.8 -0.9
Diabetes (self-reported) 0.8 1.3 3.3 0.7 0.3 1.8
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 0.9 -0.5 0.6
Medication: Ramipril 1.1 1.4 2.5 -0.8 1.6 -1.1
Medication: Simvastatin 0.9 1.3 1.7 -1.1 1.3 -1.1
Fluid intelligence score 0.9 1.9 2.1 -1.5 1.4 -1.3
Illnesses of siblings 0.4 0.5 0.9 0.3 -0.8 0.9
Neuroticism score 0.9 1.8 4.2 -0.0 -1.1 2.0
Weight 0.1 0.3 0.4 -0.4 -0.6 0.5
Impedance of arm (right) 3.0 14.1 16.5 -4.1 3.7 -3.5
Arm fat percentage (right) 0.2 1.0 2.0 -1.4 0.1 -0.9
Trunk fat-free mass 0.2 1.3 2.0 0.8 -1.1 1.4
Hip circumference 0.2 0.8 2.2 -1.5 0.2 -0.4
Time employed in main current job 1.6 1.8 3.3 -0.8 1.8 -1.2
Alcohol intake versus 10 years previously 0.3 0.4 0.7 0.7 0.1 0.9
Father’s age at death 0.5 0.6 1.0 0.8 -0.4 -1.0
Worrier / anxious feelings 0.1 0.2 0.6 0.1 0.3 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.4 -0.6 0.2 -0.0
Falls in the last year 1.0 1.4 2.6 0.4 -1.6 1.2
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 0.0 -0.6 -0.1
Number of live births 0.8 1.1 2.9 -1.7 0.1 -0.6
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.5 0.5 -0.1 0.7
Pulse rate 0.3 0.5 1.0 -0.3 -1.0 0.7
Happiness 0.1 0.1 0.3 0.0 -0.5 0.4
Noisy workplace 0.2 0.2 0.3 0.5 -0.6 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.5 -0.1 -0.7 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 2.5 -1.2 1.6 -1.4
Mouth/teeth dental problems: Dentures 0.2 0.3 0.4 0.3 0.5 -0.7
Asthma 0.4 0.8 2.0 1.4 -0.3 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.8 0.3 -0.4
Medication: Cholesterol lowering 5.7 8.8 11.1 -2.7 3.3 -2.8
Depression (self-reported) 0.1 0.1 0.2 0.1 -0.5 0.4
Medication: Lansoprazole 1.0 1.1 1.8 -0.7 1.3 -1.1
Prospective memory result 0.1 0.1 0.3 0.1 0.1 -0.6
Lung cancer (father) 0.9 1.0 2.3 -0.5 1.5 -0.7
Illnesses of mother 0.5 0.6 1.1 0.5 -1.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.6 1.3 -0.7 0.8
Pulse wave Arterial Stiffness index 0.2 0.3 0.8 0.0 0.9 -0.1
Impedance of arm (left) 2.9 13.5 15.0 -3.9 3.7 -3.4
Arm fat mass (right) 0.1 0.3 0.5 -0.6 -0.7 0.2
Trunk predicted mass 0.2 1.1 1.8 0.7 -1.0 1.4
Standing height 0.3 3.2 5.6 -2.4 1.9 -0.7
Length of working week for main job 0.5 0.6 0.7 0.8 -0.7 0.8
Exposure to tobacco smoke at home 0.4 0.4 0.6 -0.8 0.5 0.7
Breastfed as a baby 0.0 0.0 0.1 0.1 0.2 0.3
Tense / ‘highly strung’ 0.4 0.7 1.7 -0.5 0.1 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 3.5 5.3 8.9 -3.0 2.2 -1.5
Hair/balding pattern: Pattern 4 0.3 0.7 1.8 0.2 1.3 -0.4
Birth weight of first child 1.7 3.0 4.5 2.1 -1.5 1.5
Peak expiratory flow (PEF) 0.1 0.2 0.5 -0.2 0.7 0.0
Pulse wave reflection index 0.5 0.7 1.3 0.2 0.8 -1.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.4 -0.2 0.2
Loud music exposure frequency 1.0 1.1 2.0 -1.4 0.7 -0.9
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.3 -1.1 0.1 -0.2
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 3.0 -0.4 1.7 -1.0
Blood clot in the leg (DVT) 2.6 3.4 7.1 -1.2 2.7 -1.2
Medication: Paracetamol 0.6 1.0 1.9 1.4 -0.9 0.4
Headache pain in last month 0.5 0.9 1.3 1.1 -0.3 1.1
Medication for cholesterol, blood pressure or diabetes 2.0 3.4 7.5 1.3 -2.7 0.9
Glaucoma (self-reported) 1.5 1.7 3.2 1.8 -1.4 0.0
Gout (self-reported) 1.5 2.1 6.1 -0.0 2.5 -0.3
Hypothyroidism/myxoedema (self-reported) 2.7 5.2 9.0 0.4 -2.5 3.0
Medication: Amlodipine 5.5 7.8 10.4 3.1 -1.7 3.2
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.0 1.0 1.0 -0.1
Birth weight 2.8 6.1 7.6 2.0 -2.8 2.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 0.9 -1.3 -0.0
High blood pressure (siblings) 0.6 0.9 1.8 0.1 0.9 -1.3
Forced vital capacity (FVC), Best measure 0.1 0.2 0.6 0.8 0.1 0.1
Body fat percentage 0.6 2.2 4.0 -2.0 0.6 -1.5
Leg fat percentage (right) 0.7 2.6 4.1 -1.8 0.8 -2.0
Arm fat-free mass (right) 0.5 2.5 3.3 1.1 -1.8 1.8
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.7 0.3 0.5
Comparative body size at age 10 1.6 4.4 5.3 2.3 -2.3 1.6
Number of full brothers 1.2 1.6 2.9 -1.7 0.0 -1.4
Worry too long after embarrassment 0.1 0.1 0.3 -0.6 0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.2 0.5 -0.7 0.3 -0.1
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 -0.2 0.2 0.1
Number of children fathered 0.2 0.2 0.3 0.3 -0.6 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.6 3.0 4.3 2.1 -1.5 1.6
Age at first live birth 2.3 4.0 6.9 2.6 -1.0 2.0
Pulse wave peak to peak time 0.1 0.2 0.2 -0.5 -0.5 -0.1
Health satisfaction 0.3 0.4 0.6 -0.8 0.1 -0.7
Shortness of breath walking on level ground 0.9 1.0 1.7 -1.3 1.1 -0.3
Qualifications: College or University degree 0.9 2.8 4.8 2.2 -1.8 0.7
Eye problems/disorders: None of the above 2.2 2.5 4.8 -1.4 2.2 -0.9
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 -0.3 0.3 0.3
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.2 0.3 -0.5
Medication for pain relief, constipation, heartburn 0.5 0.9 1.3 -1.1 -1.1 0.5
Neck or shoulder pain in last month 0.1 0.1 0.4 -0.1 -0.2 0.6
Medication: Blood pressure 0.9 1.5 3.8 0.1 2.0 0.9
Angina (self-reported) 0.1 0.1 0.2 -0.2 0.1 0.4
Migraine (self-reported) 2.0 2.5 4.9 1.4 -0.6 2.2
Medication: Ibuprofen 0.3 0.3 0.7 0.4 0.2 -0.9
Medication: Allopurinol 2.6 3.5 8.9 -0.6 3.0 -1.1
Medication: Omeprazole 0.2 0.2 0.2 -0.5 0.4 -0.4
Medication: Seretide 50 evohaler 0.5 0.5 1.6 1.3 0.0 0.2
Mean time to correctly identify matches 0.3 0.6 1.4 -1.2 -0.2 -0.7
Heart disease (mother) 0.8 1.0 2.2 -0.3 0.8 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.4 0.5 -0.5 0.6
Whole body fat mass 0.1 0.6 1.5 -1.2 -0.0 -0.5
Leg fat mass (right) 0.1 0.4 1.0 -1.0 -0.1 -0.5
Arm predicted mass (right) 0.5 2.4 3.0 1.3 -1.6 1.7
Pulse rate, automated reading 0.6 1.9 2.6 0.9 -1.6 1.6
Alcohol intake frequency. 0.3 0.6 1.4 1.2 -0.7 -0.1
Comparative height size at age 10 0.2 1.2 2.0 -1.4 0.8 -0.9
Number of full sisters 3.9 4.8 5.2 -2.2 2.3 -2.0
Suffer from ‘nerves’ 0.3 0.5 1.4 -1.2 -0.0 -0.1
Overall health rating 0.2 0.5 0.8 -0.5 0.9 0.7
Chest pain or discomfort 1.1 1.6 2.5 -1.3 1.6 -0.6
Had major operations 4.9 5.7 7.1 -2.1 2.7 -2.3
Age at last live birth 4.1 6.0 8.0 2.7 -1.7 2.8
Family relationship satisfaction 1.2 1.5 2.7 -1.6 0.7 -1.2
Leg pain on walking 0.7 0.9 1.1 -1.0 1.0 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 4.5 0.1 -1.3 2.1
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.6 -0.1 -1.3 -0.6
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 2.8 1.2 -1.6 1.7
Medication: Aspirin 2.6 3.4 5.8 -1.3 2.4 -1.7
Supplements: Vitamin C 0.7 0.8 2.1 0.5 -0.3 1.5
Knee pain experienced in last month 0.1 0.2 0.2 -0.5 -0.4 -0.2
Hypertension (Self-reported) 0.6 1.6 4.7 -0.4 2.2 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 0.4 0.3 -0.2
Illnesses of father: Heart disease 0.6 0.8 2.2 0.2 -1.5 0.3
Illnesses of siblings: Diabetes 0.5 0.7 1.1 -0.4 -1.1 -0.9
Smoking status: Previous 1.0 1.4 2.0 -1.4 0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.0 -0.2 0.0 -0.1
Whole body fat-free mass 0.4 2.3 3.2 1.0 -1.6 1.8
Leg fat-free mass (right) 0.6 3.4 4.5 1.3 -2.0 2.1
Arm fat percentage (left) 0.2 0.9 1.7 -1.3 0.3 -0.9
Average weekly red wine intake 0.0 0.0 0.1 0.3 -0.3 -0.1
Handedness (chirality/laterality): Left-handed 2.8 3.4 6.7 -1.1 2.6 -1.6
Mood swings 1.2 2.3 4.1 0.9 -1.4 2.0
Loneliness, isolation 0.4 0.5 0.9 0.2 -1.0 0.8
Long-standing illness, disability or infirmity 0.7 1.1 2.9 -0.7 1.7 -0.4
Ever had bowel cancer screening 3.7 4.4 5.9 -2.1 1.7 -2.4
Diabetes diagnosed by doctor 0.6 1.0 2.2 0.9 -0.1 1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.9 -1.1 0.7 -1.7
Friendships satisfaction 0.8 1.0 2.5 0.5 -1.6 0.4
Qualifications: nursing, teaching 2.4 3.7 5.0 2.2 -1.2 2.2
Commuting to job workplace: Walk 1.7 1.8 3.5 0.6 -1.3 1.9
Eye problems/disorders: Cataract 1.1 1.2 1.4 1.2 -1.0 1.2
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.2 -0.1 0.2
Medication for cholesterol 0.1 0.1 0.3 -0.3 -0.0 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 1.6 1.2 0.0 1.3
Back pain experienced in last month 0.1 0.1 0.2 -0.5 -0.1 -0.4
Mineral and other dietary supplements 0.2 0.2 0.7 -0.0 -0.8 -0.1
Breast cancer (self-reported) 6.7 8.0 10.6 -3.2 2.5 -2.7
Asthma (self-reported) 0.2 0.4 1.1 1.0 -0.1 0.3
Osteoporosis (self-reported) 2.0 2.5 4.5 -1.7 2.1 0.5
Osteoarthritis (self-reported) 0.0 0.0 0.0 0.1 -0.2 -0.1
Medication: Aspirin 2.2 2.9 6.1 -1.1 2.5 -1.2
Medication: Gliclazide 1.4 1.5 2.5 1.5 -0.1 1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 1.1 1.0 -0.8 -0.2
Smoking status: Current 0.2 0.3 0.8 -0.9 0.2 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.2 2.8 1.7 0.1 0.8
Whole body water mass 0.4 2.1 3.2 1.0 -1.5 1.8
Leg predicted mass (right) 0.6 3.4 4.7 1.3 -2.0 2.2
Arm fat mass (left) 0.1 0.2 0.6 -0.8 -0.3 -0.1
Number of self-reported non-cancer illnesses 0.6 1.0 1.8 -1.1 1.4 0.1
Average weekly champagne plus white wine intake 2.0 2.8 5.6 2.4 -1.0 1.3
Miserableness 0.6 1.0 2.5 -1.6 -0.6 0.5
Guilty feelings 1.5 2.2 4.3 -0.0 -1.6 2.1
Wears glasses or contact lenses 0.4 0.4 0.8 -0.3 0.9 -0.6
Ever taken oral contraceptive pill 0.4 0.5 0.9 -0.6 1.0 -0.1
Hearing aid user 1.3 1.4 3.5 1.9 0.1 0.8
Mother’s age at death 3.3 4.1 5.2 2.0 -1.7 2.3
Financial situation satisfaction 0.4 0.5 0.6 -0.7 -0.7 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.2 0.2 -0.6
Commuting to job workplace: Public transport 0.3 0.3 0.9 0.1 -0.3 0.9
Eye problems/disorders: Glaucoma 5.8 6.9 11.2 2.6 -3.4 1.6
Medication: Blood pressure 0.3 0.5 1.5 0.2 0.1 -1.2
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.0 -0.1 -0.9 1.4
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.3 -0.4 1.5 -0.2
High cholesterol (Self-reported) 1.8 3.1 4.1 -2.0 1.6 -1.6
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.1 -0.6 -0.8
Medication: Paracetamol 0.3 0.4 0.7 0.8 -0.7 -0.2
Medication: Lisinopril 1.0 1.4 1.8 -1.0 1.1 -1.3
Medication: Atorvastatin 0.2 0.2 0.5 -0.3 -0.0 0.7
Illnesses of father: High blood pressure 0.8 1.0 1.5 1.1 -1.2 0.5
Alcohol drinker status: Never 1.8 2.2 3.4 1.8 -1.8 0.0
Ever smoked 2.3 4.0 5.4 -2.3 1.8 -1.8
Basal metabolic rate 0.3 1.4 2.1 0.5 -1.4 1.4
Leg fat percentage (left) 0.5 1.9 3.2 -1.6 0.3 -1.8
Arm fat-free mass (left) 0.3 1.7 2.6 0.6 -1.5 1.6
Number of operations (self-reported) 2.3 3.5 6.3 -1.3 2.5 -1.5
Average weekly beer plus cider intake 0.8 1.1 3.0 -0.4 -1.7 0.4
Irritability 1.0 1.6 4.6 -0.5 0.1 2.1
Risk taking 0.5 0.7 0.8 0.6 -0.9 0.9
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.0 -1.2 1.4 -0.9
Fractured/broken bones in last 5 years 0.2 0.3 0.4 0.5 0.4 0.7
Age started oral contraceptive pill 1.2 1.5 2.4 1.6 -0.8 1.2
Diastolic blood pressure, automated reading 0.0 0.1 0.1 0.1 0.4 -0.2
Ever depressed for a whole week 1.4 1.7 3.0 -1.0 1.7 -1.0
Unable to work because of sickness or disability 0.2 0.3 0.8 0.2 0.4 0.9
Commuting to job workplace: Cycle 0.4 0.4 1.1 -0.4 1.1 0.1
Myopia 2.5 3.6 6.5 -1.8 2.5 -1.1
Vascular/heart problems diagnosed by doctor 0.6 1.7 4.8 0.6 -2.2 0.1
Cholesterol lowering medication 0.2 0.2 0.4 0.3 -0.5 0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.1 0.5 0.0
Pain experienced in last month 0.6 1.1 1.4 -0.8 1.2 -1.1
Supplements: Calcium 1.1 1.2 2.2 -1.0 1.5 0.5
Basal cell carcinoma (self-reported) 0.4 0.4 1.1 1.1 -0.3 0.3
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 -0.6 0.4 -0.0
Deep venous thrombosis (DVT) (self-reported) 2.8 3.6 7.2 -1.3 2.7 -1.4
Heart disease (siblings) 0.1 0.1 0.2 -0.5 -0.1 -0.2
Alcohol drinker status: Previous 0.3 0.4 0.8 -0.1 0.5 -0.9
Pack years of smoking 0.2 0.3 0.5 0.2 0.5 -0.7
Impedance of whole body 3.3 16.7 19.8 -4.5 3.8 -4.0
Leg fat mass (left) 0.1 0.3 0.7 -0.8 -0.3 -0.4
Arm predicted mass (left) 0.4 1.8 2.5 0.7 -1.6 1.6