Hub : Genes

SRSF10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3510	0.0760	3.1e-06	0.164	NA	0.216	NA	0.227	2.2e-09	NA	4.0e-12	NA	1.0e-12
2	METSIM	Adipose	0.0514	0.0204	8.2e-04	0.021	0.018	0.018	0.018	0.005	3.1e-04	9.0e-04	9.6e-04	7.8e-04	4.8e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0998	0.0331	4.2e-06	0.054	0.049	0.063	0.055	0.061	1.6e-07	6.6e-07	1.7e-08	1.2e-07	2.4e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.3	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.2	0.0	-0.5
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	0.2	-0.9	0.9
Depression (Nagel 2018)	0.1	0.2	0.3	-0.6	0.0	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.7	-0.5	1.6	-1.0
Neuroticism (Nagel 2018)	0.2	0.5	1.3	-0.5	-0.2	1.2
Schizophrenia (2018)	0.0	0.1	0.1	-0.0	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	0.2	-0.2
Worry (Nagel 2018)	0.1	0.3	0.6	-0.5	0.0	0.8
Alzheimer’s Disease (in mother)	3.0	3.5	5.7	1.8	-1.3	2.4
Alzheimer’s Disease (in father)	0.3	0.4	0.8	-0.9	0.4	0.4
Alzheimer’s Disease (including proxy)	2.0	2.9	4.1	1.4	-1.6	2.0
Crohns Disease (2017)	0.2	0.4	1.1	-0.4	1.0	-0.2
Irritable Bowel Disease (IBD)	0.8	1.9	2.6	-1.6	1.4	-1.0
Ulcerative Colitis (UC)	0.6	1.2	2.1	-1.4	0.9	-0.8
Major Depression (MDD)	0.0	0.0	0.1	-0.2	0.1	0.3
Reaction Time	0.5	0.9	2.5	-0.5	-1.6	0.0
Verbal and Numeric Reasoning (VNR)	2.1	5.1	7.1	-1.6	2.3	-2.7
Breast Cancer	0.6	1.6	2.7	1.6	-1.4	0.4
Ovarian Cancer	2.3	3.0	5.6	-1.0	2.4	-1.6
Prostate Cancer	2.0	2.8	3.9	-1.0	2.0	-1.9
Age at First Birth	2.2	3.2	5.8	2.4	-1.1	1.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.8	-0.6	-0.3
Coronary Artery Disease (CAD)	0.3	0.3	0.6	0.6	-0.7	0.0
Crohns Disease (2012)	1.5	2.4	4.5	-1.3	2.1	-0.9
Mean Putamen Volume	1.4	1.6	2.7	1.4	-0.3	1.6
Fasting Glucose	1.0	1.2	1.8	0.9	-1.0	1.3
HbA1C	1.7	1.9	2.1	-1.5	1.2	-1.5
HDL Cholesterol	0.1	0.1	0.2	0.1	0.5	0.1
LDL Cholesterol	0.1	0.1	0.1	-0.2	0.3	-0.4
Lupus	1.8	2.7	4.5	2.1	-1.7	0.8
Neuroticism (2016)	0.3	0.4	0.5	0.3	-0.7	0.7
Primary Biliary Cirrhosis	0.3	0.5	0.6	-0.8	0.6	-0.6
Rheumatoid Arthritis	0.6	0.9	1.5	-0.7	1.2	-0.7
Schizophrenia (2014)	0.0	0.0	0.0	-0.2	0.2	-0.2
Triglycerides	5.8	9.5	14.4	3.1	-3.8	2.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.1	1.0	-0.1	0.9
Ulcerative Colitis	0.7	1.1	2.2	-1.5	0.5	-0.9
Blood Eosinophil Count	3.4	26.1	35.9	-3.2	5.7	-6.0
Blood Platelet Count	0.5	6.4	12.8	3.6	-2.1	1.3
Blood Red Count	0.9	9.1	13.8	-2.1	3.0	-3.7
Blood White Count	0.7	5.4	10.6	3.3	-2.2	0.7
Heel T-Score	0.5	4.3	5.2	-2.2	1.7	-2.3
BMI	0.3	1.9	3.2	1.0	-1.8	1.2
Height	0.1	1.5	2.4	-1.4	1.5	0.4
Waist Hip Ratio (WHR)	0.2	0.7	1.5	-1.2	0.8	-0.2
Systolic Blood Pressure	0.6	3.2	6.2	-0.5	2.5	-1.8
Smoking Status	1.0	2.3	4.7	-2.2	1.1	-1.0
Allergy or Eczema	0.1	0.3	0.6	0.1	0.5	-0.7
Cardiovascular Disease	0.4	1.4	3.4	-0.6	1.8	-0.6
Hypothyroidism (self reported)	3.0	7.0	11.0	0.2	-3.3	3.1
Respiratory disease	0.2	0.5	0.8	0.9	0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.4	1.0	-0.1	1.6
Lung FEV1/FVC ratio	0.3	1.7	2.7	0.9	-1.6	1.2
Lung FVC	0.6	3.0	8.0	2.8	-0.4	0.9
Neuroticism	0.2	0.5	1.0	-0.3	-0.6	1.0
Chronotype (morning person)	0.8	1.8	4.3	2.1	-0.9	0.6
Hair Pigment	0.1	3.1	5.1	0.7	-2.2	2.0
Tanning	0.2	1.9	3.6	-1.2	0.8	-1.9
Hand grip strength (left)	2.2	5.8	6.3	2.4	-2.5	2.3
Number of treatments/medications taken	1.1	1.9	5.0	-0.6	2.2	-0.6
Average weekly spirits intake	0.7	0.9	2.5	-0.1	0.4	-1.6
Sensitivity / hurt feelings	1.4	2.5	4.9	0.7	-1.4	2.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.1	-0.9	1.1	0.3
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.9	-0.8	-0.1
Relative age of first facial hair	0.2	0.4	1.3	0.0	-1.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.5	-0.8	1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.3	-0.6	0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.2	0.4	-0.6
Systolic blood pressure, automated reading	0.4	1.1	2.2	-0.5	1.0	-1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.7	0.2	0.6
Angina	0.1	0.1	0.3	-0.1	0.0	0.6
Medication for hormone replacement therapy	0.1	0.2	0.4	-0.3	-0.2	0.6
Vitamin and mineral supplements	0.2	0.3	0.8	0.9	-0.1	0.4
Supplements: Zinc	0.1	0.1	0.3	0.4	-0.1	0.6
Medication: Co-codamol	1.3	1.6	3.0	-1.1	0.7	-1.7
Medication: Metformin	0.5	0.7	1.0	1.0	0.4	0.9
Diabetes (father)	0.2	0.3	0.7	0.0	0.9	0.2
Diabetes (mother)	0.6	0.8	1.7	1.3	0.6	0.4
Severe depression (siblings)	2.2	2.5	3.9	-1.7	0.9	-2.0
Pack years adult smoking proportion	0.1	0.1	0.3	0.5	0.1	-0.0
Impedance of leg (right)	3.6	17.5	18.8	-4.3	4.0	-4.2
Leg fat-free mass (left)	0.4	2.0	2.7	0.9	-1.5	1.6
Trunk fat percentage	0.7	2.9	5.5	-2.3	0.8	-1.6
Hand grip strength (right)	2.9	7.9	9.4	3.1	-2.8	2.6
Townsend deprivation index at recruitment	0.2	0.3	0.8	-0.9	0.1	0.1
Current tobacco smoking	0.1	0.1	0.2	-0.4	-0.2	0.4
Average weekly fortified wine intake	6.7	7.8	12.5	-3.5	2.3	-2.4
Maternal smoking around birth	0.2	0.3	0.5	0.7	-0.6	0.2
Fed-up feelings	0.7	1.3	2.8	0.4	-0.9	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	-0.2	-0.5	0.4
Relative age voice broke	0.1	0.1	0.4	-0.1	-0.3	0.6
Taking other prescription medications	2.2	3.4	7.3	-1.6	2.7	-0.5
Age when periods started (menarche)	1.0	2.4	4.1	-0.2	-1.8	2.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.2	-0.4	1.1	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.0	1.4	-0.2	1.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.4	-0.3	-0.0
Qualifications: CSEs or equivalent	1.2	1.6	2.5	-1.6	1.0	-1.1
Serious illness, injury or assault to yourself	0.5	0.5	1.2	-1.1	0.6	-0.4
High blood pressure	0.6	1.7	4.5	-0.6	2.1	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.6	0.3	0.8	-0.6
Multivitamins +/- minerals	0.8	1.0	1.6	0.7	-1.3	1.0
Stomach or abdominal pain in last month	0.7	0.9	1.4	1.2	-0.5	1.1
Supplements: Glucosamine	0.2	0.2	0.4	-0.6	-0.0	-0.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.1	-0.9	1.1	-0.9
Medication: Atenolol	0.1	0.2	0.4	0.2	0.4	-0.6
Medication: Levothyroxine sodium	0.8	1.4	3.0	0.0	-1.0	1.7
Sitting height	0.1	0.5	1.3	-0.4	-0.1	1.1
Chronic bronchitis/emphysema (father)	1.6	1.9	3.0	-1.7	0.2	-1.6
High blood pressure (mother)	0.1	0.1	0.3	0.5	0.4	-0.1
Body mass index (BMI)	0.3	1.4	2.7	0.7	-1.6	0.9
Impedance of leg (left)	3.0	14.5	17.3	-4.2	3.3	-3.9
Leg predicted mass (left)	0.4	2.2	3.2	0.9	-1.6	1.8
Trunk fat mass	0.3	1.1	2.6	-1.6	0.4	-0.8
Waist circumference	0.2	0.6	1.6	-1.3	0.0	-0.4
Number of incorrect matches in round	0.3	0.5	1.3	-0.5	0.2	-1.1
Past tobacco smoking	2.1	3.8	6.1	2.5	-1.4	1.8
Alcohol usually taken with meals	1.6	2.6	3.4	-1.1	1.8	-1.8
Nervous feelings	0.2	0.4	1.1	-0.1	-0.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	8.9	1.3	-1.6	3.0
Hearing difficulty/problems with background noise	0.5	0.8	1.1	-1.1	-0.3	-1.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.5	0.1	0.7	0.4
Had menopause	1.0	1.3	2.3	-0.3	1.5	-1.2
Had other major operations	0.0	0.0	0.0	-0.1	-0.0	0.1
Forced vital capacity (FVC)	0.1	0.3	0.8	0.0	0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.5	1.2	-0.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.8	-1.3	0.3	-1.0
Qualifications: None of the above	0.1	0.2	0.5	-0.2	0.2	-0.7
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.4	0.2	-0.2
Mouth/teeth dental problems	1.0	1.5	3.3	0.5	-1.8	1.0
Heart attack	0.3	0.3	0.5	-0.7	0.7	-0.3
Allergy	0.1	0.3	0.5	-0.7	-0.6	-0.1
Pain all over the body in last month	0.6	0.6	0.8	-0.7	0.8	-0.9
Diabetes (self-reported)	0.8	1.3	3.3	0.7	0.3	1.8
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.9	-0.5	0.6
Medication: Ramipril	1.1	1.4	2.5	-0.8	1.6	-1.1
Medication: Simvastatin	0.9	1.3	1.7	-1.1	1.3	-1.1
Fluid intelligence score	0.9	1.9	2.1	-1.5	1.4	-1.3
Illnesses of siblings	0.4	0.5	0.9	0.3	-0.8	0.9
Neuroticism score	0.9	1.8	4.2	-0.0	-1.1	2.0
Weight	0.1	0.3	0.4	-0.4	-0.6	0.5
Impedance of arm (right)	3.0	14.1	16.5	-4.1	3.7	-3.5
Arm fat percentage (right)	0.2	1.0	2.0	-1.4	0.1	-0.9
Trunk fat-free mass	0.2	1.3	2.0	0.8	-1.1	1.4
Hip circumference	0.2	0.8	2.2	-1.5	0.2	-0.4
Time employed in main current job	1.6	1.8	3.3	-0.8	1.8	-1.2
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.7	0.1	0.9
Father’s age at death	0.5	0.6	1.0	0.8	-0.4	-1.0
Worrier / anxious feelings	0.1	0.2	0.6	0.1	0.3	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.4	-0.6	0.2	-0.0
Falls in the last year	1.0	1.4	2.6	0.4	-1.6	1.2
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.0	-0.6	-0.1
Number of live births	0.8	1.1	2.9	-1.7	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	0.5	-0.1	0.7
Pulse rate	0.3	0.5	1.0	-0.3	-1.0	0.7
Happiness	0.1	0.1	0.3	0.0	-0.5	0.4
Noisy workplace	0.2	0.2	0.3	0.5	-0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.1	-0.7	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	2.5	-1.2	1.6	-1.4
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.3	0.5	-0.7
Asthma	0.4	0.8	2.0	1.4	-0.3	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.8	0.3	-0.4
Medication: Cholesterol lowering	5.7	8.8	11.1	-2.7	3.3	-2.8
Depression (self-reported)	0.1	0.1	0.2	0.1	-0.5	0.4
Medication: Lansoprazole	1.0	1.1	1.8	-0.7	1.3	-1.1
Prospective memory result	0.1	0.1	0.3	0.1	0.1	-0.6
Lung cancer (father)	0.9	1.0	2.3	-0.5	1.5	-0.7
Illnesses of mother	0.5	0.6	1.1	0.5	-1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.6	1.3	-0.7	0.8
Pulse wave Arterial Stiffness index	0.2	0.3	0.8	0.0	0.9	-0.1
Impedance of arm (left)	2.9	13.5	15.0	-3.9	3.7	-3.4
Arm fat mass (right)	0.1	0.3	0.5	-0.6	-0.7	0.2
Trunk predicted mass	0.2	1.1	1.8	0.7	-1.0	1.4
Standing height	0.3	3.2	5.6	-2.4	1.9	-0.7
Length of working week for main job	0.5	0.6	0.7	0.8	-0.7	0.8
Exposure to tobacco smoke at home	0.4	0.4	0.6	-0.8	0.5	0.7
Breastfed as a baby	0.0	0.0	0.1	0.1	0.2	0.3
Tense / ‘highly strung’	0.4	0.7	1.7	-0.5	0.1	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.3	8.9	-3.0	2.2	-1.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.8	0.2	1.3	-0.4
Birth weight of first child	1.7	3.0	4.5	2.1	-1.5	1.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	-0.2	0.7	0.0
Pulse wave reflection index	0.5	0.7	1.3	0.2	0.8	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	-0.2	0.2
Loud music exposure frequency	1.0	1.1	2.0	-1.4	0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.3	-1.1	0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	3.0	-0.4	1.7	-1.0
Blood clot in the leg (DVT)	2.6	3.4	7.1	-1.2	2.7	-1.2
Medication: Paracetamol	0.6	1.0	1.9	1.4	-0.9	0.4
Headache pain in last month	0.5	0.9	1.3	1.1	-0.3	1.1
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	7.5	1.3	-2.7	0.9
Glaucoma (self-reported)	1.5	1.7	3.2	1.8	-1.4	0.0
Gout (self-reported)	1.5	2.1	6.1	-0.0	2.5	-0.3
Hypothyroidism/myxoedema (self-reported)	2.7	5.2	9.0	0.4	-2.5	3.0
Medication: Amlodipine	5.5	7.8	10.4	3.1	-1.7	3.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	1.0	1.0	-0.1
Birth weight	2.8	6.1	7.6	2.0	-2.8	2.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	0.9	-1.3	-0.0
High blood pressure (siblings)	0.6	0.9	1.8	0.1	0.9	-1.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.8	0.1	0.1
Body fat percentage	0.6	2.2	4.0	-2.0	0.6	-1.5
Leg fat percentage (right)	0.7	2.6	4.1	-1.8	0.8	-2.0
Arm fat-free mass (right)	0.5	2.5	3.3	1.1	-1.8	1.8
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.7	0.3	0.5
Comparative body size at age 10	1.6	4.4	5.3	2.3	-2.3	1.6
Number of full brothers	1.2	1.6	2.9	-1.7	0.0	-1.4
Worry too long after embarrassment	0.1	0.1	0.3	-0.6	0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.7	0.3	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.2	0.2	0.1
Number of children fathered	0.2	0.2	0.3	0.3	-0.6	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.3	2.1	-1.5	1.6
Age at first live birth	2.3	4.0	6.9	2.6	-1.0	2.0
Pulse wave peak to peak time	0.1	0.2	0.2	-0.5	-0.5	-0.1
Health satisfaction	0.3	0.4	0.6	-0.8	0.1	-0.7
Shortness of breath walking on level ground	0.9	1.0	1.7	-1.3	1.1	-0.3
Qualifications: College or University degree	0.9	2.8	4.8	2.2	-1.8	0.7
Eye problems/disorders: None of the above	2.2	2.5	4.8	-1.4	2.2	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.3	0.3	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.2	0.3	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	1.3	-1.1	-1.1	0.5
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.1	-0.2	0.6
Medication: Blood pressure	0.9	1.5	3.8	0.1	2.0	0.9
Angina (self-reported)	0.1	0.1	0.2	-0.2	0.1	0.4
Migraine (self-reported)	2.0	2.5	4.9	1.4	-0.6	2.2
Medication: Ibuprofen	0.3	0.3	0.7	0.4	0.2	-0.9
Medication: Allopurinol	2.6	3.5	8.9	-0.6	3.0	-1.1
Medication: Omeprazole	0.2	0.2	0.2	-0.5	0.4	-0.4
Medication: Seretide 50 evohaler	0.5	0.5	1.6	1.3	0.0	0.2
Mean time to correctly identify matches	0.3	0.6	1.4	-1.2	-0.2	-0.7
Heart disease (mother)	0.8	1.0	2.2	-0.3	0.8	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	0.5	-0.5	0.6
Whole body fat mass	0.1	0.6	1.5	-1.2	-0.0	-0.5
Leg fat mass (right)	0.1	0.4	1.0	-1.0	-0.1	-0.5
Arm predicted mass (right)	0.5	2.4	3.0	1.3	-1.6	1.7
Pulse rate, automated reading	0.6	1.9	2.6	0.9	-1.6	1.6
Alcohol intake frequency.	0.3	0.6	1.4	1.2	-0.7	-0.1
Comparative height size at age 10	0.2	1.2	2.0	-1.4	0.8	-0.9
Number of full sisters	3.9	4.8	5.2	-2.2	2.3	-2.0
Suffer from ‘nerves’	0.3	0.5	1.4	-1.2	-0.0	-0.1
Overall health rating	0.2	0.5	0.8	-0.5	0.9	0.7
Chest pain or discomfort	1.1	1.6	2.5	-1.3	1.6	-0.6
Had major operations	4.9	5.7	7.1	-2.1	2.7	-2.3
Age at last live birth	4.1	6.0	8.0	2.7	-1.7	2.8
Family relationship satisfaction	1.2	1.5	2.7	-1.6	0.7	-1.2
Leg pain on walking	0.7	0.9	1.1	-1.0	1.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.5	0.1	-1.3	2.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.6	-0.1	-1.3	-0.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.8	1.2	-1.6	1.7
Medication: Aspirin	2.6	3.4	5.8	-1.3	2.4	-1.7
Supplements: Vitamin C	0.7	0.8	2.1	0.5	-0.3	1.5
Knee pain experienced in last month	0.1	0.2	0.2	-0.5	-0.4	-0.2
Hypertension (Self-reported)	0.6	1.6	4.7	-0.4	2.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.4	0.3	-0.2
Illnesses of father: Heart disease	0.6	0.8	2.2	0.2	-1.5	0.3
Illnesses of siblings: Diabetes	0.5	0.7	1.1	-0.4	-1.1	-0.9
Smoking status: Previous	1.0	1.4	2.0	-1.4	0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	-0.2	0.0	-0.1
Whole body fat-free mass	0.4	2.3	3.2	1.0	-1.6	1.8
Leg fat-free mass (right)	0.6	3.4	4.5	1.3	-2.0	2.1
Arm fat percentage (left)	0.2	0.9	1.7	-1.3	0.3	-0.9
Average weekly red wine intake	0.0	0.0	0.1	0.3	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	2.8	3.4	6.7	-1.1	2.6	-1.6
Mood swings	1.2	2.3	4.1	0.9	-1.4	2.0
Loneliness, isolation	0.4	0.5	0.9	0.2	-1.0	0.8
Long-standing illness, disability or infirmity	0.7	1.1	2.9	-0.7	1.7	-0.4
Ever had bowel cancer screening	3.7	4.4	5.9	-2.1	1.7	-2.4
Diabetes diagnosed by doctor	0.6	1.0	2.2	0.9	-0.1	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.9	-1.1	0.7	-1.7
Friendships satisfaction	0.8	1.0	2.5	0.5	-1.6	0.4
Qualifications: nursing, teaching	2.4	3.7	5.0	2.2	-1.2	2.2
Commuting to job workplace: Walk	1.7	1.8	3.5	0.6	-1.3	1.9
Eye problems/disorders: Cataract	1.1	1.2	1.4	1.2	-1.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.2	-0.1	0.2
Medication for cholesterol	0.1	0.1	0.3	-0.3	-0.0	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	1.2	0.0	1.3
Back pain experienced in last month	0.1	0.1	0.2	-0.5	-0.1	-0.4
Mineral and other dietary supplements	0.2	0.2	0.7	-0.0	-0.8	-0.1
Breast cancer (self-reported)	6.7	8.0	10.6	-3.2	2.5	-2.7
Asthma (self-reported)	0.2	0.4	1.1	1.0	-0.1	0.3
Osteoporosis (self-reported)	2.0	2.5	4.5	-1.7	2.1	0.5
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1
Medication: Aspirin	2.2	2.9	6.1	-1.1	2.5	-1.2
Medication: Gliclazide	1.4	1.5	2.5	1.5	-0.1	1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	1.0	-0.8	-0.2
Smoking status: Current	0.2	0.3	0.8	-0.9	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	2.8	1.7	0.1	0.8
Whole body water mass	0.4	2.1	3.2	1.0	-1.5	1.8
Leg predicted mass (right)	0.6	3.4	4.7	1.3	-2.0	2.2
Arm fat mass (left)	0.1	0.2	0.6	-0.8	-0.3	-0.1
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-1.1	1.4	0.1
Average weekly champagne plus white wine intake	2.0	2.8	5.6	2.4	-1.0	1.3
Miserableness	0.6	1.0	2.5	-1.6	-0.6	0.5
Guilty feelings	1.5	2.2	4.3	-0.0	-1.6	2.1
Wears glasses or contact lenses	0.4	0.4	0.8	-0.3	0.9	-0.6
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.6	1.0	-0.1
Hearing aid user	1.3	1.4	3.5	1.9	0.1	0.8
Mother’s age at death	3.3	4.1	5.2	2.0	-1.7	2.3
Financial situation satisfaction	0.4	0.5	0.6	-0.7	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.2	0.2	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.9	0.1	-0.3	0.9
Eye problems/disorders: Glaucoma	5.8	6.9	11.2	2.6	-3.4	1.6
Medication: Blood pressure	0.3	0.5	1.5	0.2	0.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.0	-0.1	-0.9	1.4
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	-0.4	1.5	-0.2
High cholesterol (Self-reported)	1.8	3.1	4.1	-2.0	1.6	-1.6
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.1	-0.6	-0.8
Medication: Paracetamol	0.3	0.4	0.7	0.8	-0.7	-0.2
Medication: Lisinopril	1.0	1.4	1.8	-1.0	1.1	-1.3
Medication: Atorvastatin	0.2	0.2	0.5	-0.3	-0.0	0.7
Illnesses of father: High blood pressure	0.8	1.0	1.5	1.1	-1.2	0.5
Alcohol drinker status: Never	1.8	2.2	3.4	1.8	-1.8	0.0
Ever smoked	2.3	4.0	5.4	-2.3	1.8	-1.8
Basal metabolic rate	0.3	1.4	2.1	0.5	-1.4	1.4
Leg fat percentage (left)	0.5	1.9	3.2	-1.6	0.3	-1.8
Arm fat-free mass (left)	0.3	1.7	2.6	0.6	-1.5	1.6
Number of operations (self-reported)	2.3	3.5	6.3	-1.3	2.5	-1.5
Average weekly beer plus cider intake	0.8	1.1	3.0	-0.4	-1.7	0.4
Irritability	1.0	1.6	4.6	-0.5	0.1	2.1
Risk taking	0.5	0.7	0.8	0.6	-0.9	0.9
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.0	-1.2	1.4	-0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.4	0.5	0.4	0.7
Age started oral contraceptive pill	1.2	1.5	2.4	1.6	-0.8	1.2
Diastolic blood pressure, automated reading	0.0	0.1	0.1	0.1	0.4	-0.2
Ever depressed for a whole week	1.4	1.7	3.0	-1.0	1.7	-1.0
Unable to work because of sickness or disability	0.2	0.3	0.8	0.2	0.4	0.9
Commuting to job workplace: Cycle	0.4	0.4	1.1	-0.4	1.1	0.1
Myopia	2.5	3.6	6.5	-1.8	2.5	-1.1
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.8	0.6	-2.2	0.1
Cholesterol lowering medication	0.2	0.2	0.4	0.3	-0.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	0.5	0.0
Pain experienced in last month	0.6	1.1	1.4	-0.8	1.2	-1.1
Supplements: Calcium	1.1	1.2	2.2	-1.0	1.5	0.5
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	1.1	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.6	0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	7.2	-1.3	2.7	-1.4
Heart disease (siblings)	0.1	0.1	0.2	-0.5	-0.1	-0.2
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.1	0.5	-0.9
Pack years of smoking	0.2	0.3	0.5	0.2	0.5	-0.7
Impedance of whole body	3.3	16.7	19.8	-4.5	3.8	-4.0
Leg fat mass (left)	0.1	0.3	0.7	-0.8	-0.3	-0.4
Arm predicted mass (left)	0.4	1.8	2.5	0.7	-1.6	1.6