Best TWAS P=1.01e-26 · Best GWAS P=1.62e-41 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HIGD1A | 0.11 | 0.01 | enet | 17 | 0.00 | 3.0e-01 | -5.4 | -6.5 | 1.0e-10 | -0.03 | 0.08 | 0.05 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CCDC13-AS1 | 0.12 | 0.10 | lasso | 4 | 0.09 | 3.1e-05 | -5.6 | -5.4 | 7.9e-08 | -0.10 | 0.77 | 0.01 | FALSE |
| 3 | GTEx | Brain Cortex | HIGD1A | 0.28 | 0.02 | enet | 36 | 0.12 | 3.6e-04 | 3.4 | -6.9 | 6.6e-12 | -0.26 | 0.08 | 0.57 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CCDC13-AS1 | 0.34 | 0.22 | enet | 32 | 0.24 | 6.6e-18 | -5.6 | -5.3 | 1.0e-07 | -0.14 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | CCDC13 | 0.24 | 0.22 | lasso | 3 | 0.20 | 1.2e-14 | -5.4 | -5.5 | 3.0e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Colon Transverse | KRBOX1 | 0.15 | 0.00 | lasso | 4 | 0.00 | 3.8e-01 | 4.9 | 5.7 | 9.6e-09 | 0.19 | 0.05 | 0.07 | TRUE |
| 7 | GTEx | Esophagus Mucosa | CCDC13-AS1 | 0.08 | 0.04 | lasso | 2 | 0.03 | 6.5e-03 | -5.5 | -5.6 | 2.6e-08 | -0.12 | 0.34 | 0.11 | FALSE |
| 8 | GTEx | Esophagus Muscularis | HIGD1A | 0.18 | 0.00 | enet | 41 | 0.04 | 9.8e-04 | -7.8 | -6.5 | 1.0e-10 | -0.12 | 0.58 | 0.02 | FALSE |
| 9 | GTEx | Esophagus Muscularis | CCDC13 | 0.15 | 0.16 | lasso | 1 | 0.15 | 2.7e-09 | -5.4 | -5.4 | 6.0e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Lung | ZNF662 | 0.10 | 0.00 | lasso | 5 | 0.00 | 2.6e-01 | -10.2 | 10.1 | 7.2e-24 | 0.21 | 0.09 | 0.24 | TRUE |
| 11 | GTEx | Pituitary | CCDC13 | 0.34 | 0.10 | lasso | 4 | 0.18 | 2.6e-05 | -5.4 | -8.0 | 1.6e-15 | -0.19 | 0.10 | 0.06 | TRUE |
| 12 | GTEx | Whole Blood | CCDC13-AS1 | 0.09 | 0.07 | lasso | 5 | 0.07 | 2.2e-07 | -5.6 | -5.4 | 6.0e-08 | -0.08 | 0.97 | 0.00 | FALSE |
| 13 | METSIM | Adipose | ACKR2 | 0.05 | 0.02 | enet | 7 | 0.04 | 6.7e-07 | -8.8 | 5.6 | 2.6e-08 | 0.06 | 0.38 | 0.02 | FALSE |
| 14 | METSIM | Adipose | CCDC13 | 0.15 | 0.14 | bslmm | 498 | 0.13 | 8.9e-19 | -5.4 | -5.3 | 1.2e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | ACKR2 | 0.21 | 0.13 | lasso | 6 | 0.15 | 2.6e-18 | -9.6 | -8.8 | 9.1e-19 | -0.21 | 1.00 | 0.00 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | HIGD1A | 0.40 | 0.38 | enet | 35 | 0.41 | 3.1e-56 | 3.3 | -6.1 | 1.3e-09 | -0.19 | 1.00 | 0.00 | TRUE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NKTR | 0.02 | 0.01 | enet | 11 | 0.03 | 7.7e-07 | -2.0 | 5.3 | 1.3e-07 | 0.12 | 0.06 | 0.85 | TRUE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CCDC13 | 0.11 | 0.08 | lasso | 2 | 0.06 | 1.4e-03 | -5.4 | -5.4 | 6.8e-08 | -0.12 | 0.03 | 0.16 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CYP8B1 | 0.04 | 0.03 | blup | 45 | 0.04 | 1.3e-04 | -9.3 | 10.7 | 1.0e-26 | 0.34 | 0.23 | 0.12 | TRUE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC13 | 0.09 | 0.06 | lasso | 4 | 0.04 | 4.2e-04 | -5.4 | -6.4 | 1.5e-10 | -0.15 | 0.07 | 0.57 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | CYP8B1 | 0.04 | 0.01 | blup | 46 | 0.03 | 2.3e-04 | -9.3 | 9.1 | 1.1e-19 | 0.21 | 0.12 | 0.02 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | HHATL | 0.09 | 0.01 | enet | 11 | 0.02 | 3.1e-03 | 7.3 | -6.0 | 2.0e-09 | -0.14 | 0.00 | 0.96 | FALSE |