Hub : Genes

THAP9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0718 0.0327 5.7e-03 0.006 NA -0.003 NA 0.007 0.1200 NA 0.64000 NA 0.10000
2 TCGA Brain Lower Grade Glioma 0.0259 0.0191 6.1e-03 0.029 0.022 0.022 NA 0.025 0.0003 1.5e-03 0.00130 NA 0.00072
3 TCGA Prostate Adenocarcinoma 0.0438 0.0256 4.5e-05 0.036 0.037 0.036 NA 0.035 0.0001 7.8e-05 0.00011 NA 0.00014

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 2.0 -1.4 0.7 0.6
Bipolar Disorder or Schizophrenia 2.5 6.2 6.7 -2.6 2.6 2.3
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 -0.0 -0.0 0.1
Depression (Nagel 2018) 0.2 0.2 0.4 -0.7 0.3 0.4
Intelligence (Savage-Jansen 2018) 0.7 2.1 5.5 2.3 -0.6 -0.7
Neuroticism (Nagel 2018) 1.9 4.4 5.4 -1.6 2.3 2.3
Schizophrenia (2018) 3.0 6.2 7.6 -2.2 2.8 2.5
Schizophrenia vs Biploar Disorder 1.9 2.4 3.2 -1.5 1.3 1.8
Worry (Nagel 2018) 5.5 11.5 13.4 -2.9 3.7 3.5
Alzheimer’s Disease (in mother) 1.0 1.1 1.7 -0.1 -1.3 -1.3
Alzheimer’s Disease (in father) 0.4 0.5 0.6 0.8 0.8 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 0.9 0.4 -0.9 -0.9
Crohns Disease (2017) 1.5 3.4 5.3 -0.3 2.3 2.2
Irritable Bowel Disease (IBD) 2.2 5.1 8.2 -0.5 2.9 2.6
Ulcerative Colitis (UC) 1.6 2.9 4.8 -0.5 2.2 1.9
Major Depression (MDD) 3.5 4.2 6.2 -2.5 1.8 1.8
Reaction Time 0.4 0.8 1.0 -0.6 1.0 1.0
Verbal and Numeric Reasoning (VNR) 2.1 5.1 5.4 2.2 -2.3 -2.3
Breast Cancer 4.1 9.8 13.5 -3.7 2.7 3.0
Ovarian Cancer 5.5 7.2 9.2 2.6 -2.4 -3.0
Prostate Cancer 0.7 0.9 1.8 0.4 1.3 1.0
Age at First Birth 1.0 1.4 3.5 1.9 -0.3 -0.8
Bipolar Disorder (2011) 0.1 0.1 0.3 -0.5 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 0.4 0.4 0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.1 -0.1 -0.2 -0.1
Crohns Disease (2012) 0.5 0.8 1.4 0.0 1.2 1.0
Mean Putamen Volume 1.6 1.9 2.4 -1.2 1.5 1.3
Fasting Glucose 1.2 1.5 2.7 -0.6 1.6 1.1
HbA1C 0.8 0.9 1.2 0.6 -1.1 -1.0
HDL Cholesterol 3.8 6.4 8.9 -1.4 3.0 2.9
LDL Cholesterol 0.2 0.3 0.5 0.0 -0.6 -0.7
Lupus 2.2 3.3 4.5 -1.1 2.1 2.1
Neuroticism (2016) 1.6 2.4 3.2 -1.6 1.1 1.8
Primary Biliary Cirrhosis 0.8 1.1 1.6 -1.3 0.9 1.0
Rheumatoid Arthritis 0.4 0.5 0.8 0.1 -0.8 -0.9
Schizophrenia (2014) 2.6 5.7 6.6 -2.1 2.5 2.6
Triglycerides 1.0 1.6 3.6 -1.9 0.8 0.8
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.6 1.6 -0.5 -0.7
Ulcerative Colitis 2.6 3.8 5.3 -1.0 2.3 2.3
Blood Eosinophil Count 2.8 21.5 37.1 0.9 -6.1 -5.1
Blood Platelet Count 0.6 6.8 11.3 3.4 2.7 1.3
Blood Red Count 0.7 6.7 15.4 -3.9 -2.1 -0.4
Blood White Count 2.8 20.7 35.9 1.3 -6.0 -5.0
Heel T-Score 0.1 0.4 0.6 0.6 -0.7 -0.7
BMI 0.8 4.4 5.4 1.8 -2.3 -2.2
Height 0.3 5.1 9.4 0.5 -3.1 -2.4
Waist Hip Ratio (WHR) 0.4 1.8 2.5 1.3 -1.6 -1.2
Systolic Blood Pressure 3.0 15.1 23.0 -2.6 4.8 3.9
Smoking Status 3.4 8.1 11.6 -3.4 2.3 2.8
Allergy or Eczema 0.0 0.0 0.0 0.1 -0.1 -0.2
Cardiovascular Disease 7.0 23.3 24.4 -4.8 4.9 4.7
Hypothyroidism (self reported) 0.2 0.4 0.6 -0.0 -0.8 -0.6
Respiratory disease 0.1 0.3 0.5 0.4 -0.7 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 0.5 -0.0 -0.1
Lung FEV1/FVC ratio 4.2 21.5 22.1 4.6 -4.6 -4.7
Lung FVC 0.1 0.6 1.6 1.3 0.1 -0.1
Neuroticism 2.6 6.4 7.4 -2.4 2.5 2.7
Chronotype (morning person) 1.1 2.6 5.6 0.4 -2.4 -1.4
Hair Pigment 0.0 0.8 1.1 -1.1 0.6 0.9
Tanning 0.0 0.1 0.2 0.5 -0.2 -0.4
Hand grip strength (left) 0.0 0.1 0.3 -0.1 0.3 0.5
Number of treatments/medications taken 1.2 2.1 3.2 -1.8 1.2 1.3
Average weekly spirits intake 3.6 4.5 7.2 1.2 -2.7 -2.2
Sensitivity / hurt feelings 1.0 1.7 2.5 -1.6 0.9 1.3
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.4 -0.2 0.4 0.6
Hearing difficulty/problems: Yes 1.4 2.1 3.1 0.9 -1.5 -1.8
Relative age of first facial hair 0.9 1.8 2.6 -0.9 1.6 1.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.4 0.2 -1.3 -1.6
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.6 -1.3 0.7 0.8
Ever had hysterectomy (womb removed) 0.0 0.1 0.1 0.2 -0.4 -0.1
Systolic blood pressure, automated reading 1.2 3.5 6.4 -0.9 2.5 1.9
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.0 0.3 0.2
Angina 0.3 0.3 0.6 -0.6 -0.8 -0.4
Medication for hormone replacement therapy 2.0 2.3 6.7 -2.6 0.2 0.3
Vitamin and mineral supplements 0.2 0.3 0.7 0.1 -0.9 -0.5
Supplements: Zinc 1.3 1.4 1.8 -0.8 1.4 1.2
Medication: Co-codamol 0.2 0.3 0.6 0.8 0.4 0.2
Medication: Metformin 0.3 0.4 1.0 1.0 -0.1 -0.3
Diabetes (father) 0.5 0.6 1.5 -0.1 -1.2 -0.4
Diabetes (mother) 0.4 0.5 0.8 0.5 -0.9 -0.7
Severe depression (siblings) 0.6 0.7 1.2 -0.1 1.1 1.0
Pack years adult smoking proportion 0.4 0.6 0.8 -0.9 0.5 0.9
Impedance of leg (right) 0.1 0.3 0.6 -0.1 -0.4 -0.8
Leg fat-free mass (left) 0.1 0.6 1.5 -0.0 -1.2 -0.5
Trunk fat percentage 1.2 4.9 7.4 1.0 -2.7 -2.5
Hand grip strength (right) 0.0 0.1 0.2 0.2 -0.4 -0.1
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.4 0.3 0.4
Current tobacco smoking 3.7 6.0 8.6 -2.9 2.0 2.4
Average weekly fortified wine intake 0.7 0.8 1.3 0.1 -1.2 -1.0
Maternal smoking around birth 0.4 0.6 0.9 0.4 -1.0 -0.9
Fed-up feelings 0.2 0.4 1.0 -1.0 0.0 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.4 -1.2 0.5 0.8
Relative age voice broke 0.3 0.4 1.0 -1.0 -0.1 -0.5
Taking other prescription medications 0.0 0.0 0.1 -0.1 -0.0 -0.3
Age when periods started (menarche) 0.2 0.4 1.2 -1.1 0.1 -0.2
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 0.2 0.2 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 2.8 0.8 -1.7 -1.6
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.1 0.6 0.6
Qualifications: CSEs or equivalent 0.2 0.2 0.3 -0.6 -0.5 -0.2
Serious illness, injury or assault to yourself 0.4 0.5 1.0 1.0 -0.2 -0.6
High blood pressure 5.1 14.2 18.7 -3.0 4.3 3.8
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.1 -0.1 -0.1
Multivitamins +/- minerals 0.6 0.8 1.2 -0.9 1.1 0.6
Stomach or abdominal pain in last month 0.6 0.7 2.1 -1.4 -0.0 0.0
Supplements: Glucosamine 1.6 2.1 4.2 0.1 2.0 1.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.9 -0.9 -0.3 -0.3
Medication: Atenolol 0.5 0.6 0.7 -0.7 0.8 0.8
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.5 0.3 0.6
Sitting height 0.2 1.3 1.9 -1.4 0.6 1.3
Chronic bronchitis/emphysema (father) 2.8 3.3 3.9 -1.5 1.9 2.0
High blood pressure (mother) 1.2 1.6 2.9 0.5 1.7 1.3
Body mass index (BMI) 0.7 2.8 3.6 1.3 -1.9 -1.7
Impedance of leg (left) 0.0 0.0 0.1 -0.1 0.0 -0.4
Leg predicted mass (left) 0.1 0.5 1.2 -0.0 -1.1 -0.4
Trunk fat mass 1.2 5.3 8.2 1.1 -2.9 -2.5
Waist circumference 1.6 5.9 8.4 1.7 -2.9 -2.5
Number of incorrect matches in round 0.2 0.3 0.4 -0.3 0.7 0.6
Past tobacco smoking 1.7 3.2 3.4 1.7 -1.8 -1.8
Alcohol usually taken with meals 0.4 0.6 1.2 -1.1 0.6 0.6
Nervous feelings 2.2 4.1 4.7 -1.8 2.0 2.2
Frequency of tenseness / restlessness in last 2 weeks 4.4 6.8 8.9 -2.2 2.6 3.0
Hearing difficulty/problems with background noise 0.4 0.6 0.8 -0.5 0.9 0.9
Hair/balding pattern: Pattern 2 0.3 0.4 0.7 0.3 0.8 0.6
Had menopause 0.3 0.3 0.8 0.9 -0.2 -0.4
Had other major operations 0.3 0.4 0.5 -0.7 0.6 0.5
Forced vital capacity (FVC) 0.3 1.2 1.6 0.9 -1.3 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.4 0.5 -0.4 -0.6
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.4 -0.5 1.2 1.0
Qualifications: None of the above 0.6 1.2 1.5 -1.2 0.8 1.2
Financial difficulties in last 2 years 0.7 0.9 1.4 0.1 -1.1 -1.2
Mouth/teeth dental problems 0.0 0.0 0.0 0.2 -0.2 0.0
Heart attack 0.7 0.9 1.9 -1.4 0.4 0.8
Allergy 0.0 0.0 0.0 0.2 0.2 -0.1
Pain all over the body in last month 0.3 0.3 0.6 0.7 -0.1 -0.5
Diabetes (self-reported) 1.2 1.9 2.9 1.7 -1.2 -1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.4 -0.3 0.1
Medication: Ramipril 0.9 1.2 3.4 1.8 0.1 -0.4
Medication: Simvastatin 1.0 1.5 1.9 -0.9 1.4 1.3
Fluid intelligence score 0.4 0.9 1.9 1.4 -0.5 -0.8
Illnesses of siblings 0.3 0.5 0.7 -0.4 -0.8 -0.7
Neuroticism score 6.0 12.4 15.8 -3.1 3.5 4.0
Weight 0.6 2.9 4.8 0.9 -2.2 -1.8
Impedance of arm (right) 0.1 0.5 0.6 -0.5 -0.8 -0.7
Arm fat percentage (right) 1.0 4.1 6.3 1.0 -2.5 -2.2
Trunk fat-free mass 0.1 0.5 1.2 0.3 -1.1 -0.5
Hip circumference 1.1 4.6 7.1 1.2 -2.7 -2.3
Time employed in main current job 0.9 1.0 1.3 -1.1 0.7 1.1
Alcohol intake versus 10 years previously 1.8 2.7 5.5 2.4 -0.9 -1.4
Father’s age at death 0.8 1.1 2.2 0.1 1.5 1.0
Worrier / anxious feelings 4.4 8.3 9.8 -2.5 2.9 3.1
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 -0.3 -0.1 0.2
Falls in the last year 0.8 1.1 1.3 0.9 -1.1 -1.2
Hair/balding pattern: Pattern 3 0.5 0.7 1.0 -1.0 0.9 0.6
Number of live births 2.4 3.4 4.5 -1.2 2.1 2.1
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 5.3 1.9 -2.3 -2.2
Pulse rate 0.8 1.4 2.6 -1.6 1.1 0.8
Happiness 1.8 2.2 3.2 -1.8 1.1 1.5
Noisy workplace 0.3 0.3 0.7 -0.9 -0.5 0.2
Qualifications: A levels/AS levels or equivalent 0.4 1.0 1.6 1.3 -0.6 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.2 0.5 0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.2 -0.3 0.5 0.4
Asthma 0.2 0.3 0.9 1.0 0.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 4.8 -2.2 1.4 1.7
Medication: Cholesterol lowering 0.1 0.2 0.3 -0.4 0.4 0.6
Depression (self-reported) 0.0 0.0 0.1 -0.2 0.2 0.0
Medication: Lansoprazole 0.9 1.0 2.8 1.7 -0.4 -0.4
Prospective memory result 0.3 0.4 0.9 1.0 -0.3 -0.3
Lung cancer (father) 0.2 0.3 0.7 -0.9 -0.3 -0.1
Illnesses of mother 1.2 1.5 1.8 -1.2 1.1 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.6 7.1 2.5 -2.7 -2.5
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 -1.1 0.5 0.1
Impedance of arm (left) 0.1 0.5 0.8 -0.2 -0.9 -0.9
Arm fat mass (right) 0.9 3.8 6.2 0.9 -2.5 -2.1
Trunk predicted mass 0.1 0.6 1.4 0.4 -1.2 -0.6
Standing height 0.1 0.6 1.2 -0.5 -1.1 -0.4
Length of working week for main job 0.7 0.7 1.3 0.2 -1.2 -0.9
Exposure to tobacco smoke at home 0.1 0.1 0.4 -0.2 -0.6 0.2
Breastfed as a baby 0.1 0.1 0.1 0.3 -0.3 -0.3
Tense / ‘highly strung’ 8.4 13.9 14.4 -3.6 3.8 3.8
Seen doctor (GP) for nerves, anxiety, tension or depression 4.5 6.9 9.0 -3.0 2.3 2.5
Hair/balding pattern: Pattern 4 0.1 0.2 0.4 -0.3 0.7 0.2
Birth weight of first child 0.1 0.3 0.3 0.5 0.5 0.4
Peak expiratory flow (PEF) 3.6 8.3 8.4 2.9 -2.9 -2.9
Pulse wave reflection index 0.0 0.0 0.1 0.2 0.2 0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.4 0.1 0.4
Loud music exposure frequency 2.8 3.1 4.5 -1.3 1.7 2.1
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.3 1.1 -1.1 -1.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.8 0.2 -0.3 -0.9
Blood clot in the leg (DVT) 0.8 1.1 1.6 -1.3 -1.0 -0.7
Medication: Paracetamol 0.9 1.5 2.0 -1.2 1.1 1.4
Headache pain in last month 0.1 0.1 0.4 -0.6 0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 1.4 1.1 -1.2 -1.2
Glaucoma (self-reported) 0.0 0.0 0.1 -0.2 0.1 0.1
Gout (self-reported) 2.5 3.5 4.8 2.2 -1.6 -1.8
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.0 -0.1 -0.1 0.1
Medication: Amlodipine 3.0 4.2 5.5 -1.3 2.3 2.3
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.6 0.1 -0.2 -0.8
Birth weight 0.4 0.8 1.0 -0.8 1.0 0.9
Chronic bronchitis/emphysema (mother) 0.0 0.0 0.1 0.0 -0.3 -0.3
High blood pressure (siblings) 1.0 1.5 1.8 1.3 1.3 1.0
Forced vital capacity (FVC), Best measure 0.7 2.5 3.0 1.6 -1.7 -1.4
Body fat percentage 1.2 4.6 6.5 1.1 -2.5 -2.4
Leg fat percentage (right) 0.9 3.3 4.4 1.2 -2.0 -2.1
Arm fat-free mass (right) 0.1 0.3 0.8 0.3 -0.9 -0.4
Exposure to tobacco smoke outside home 0.6 0.7 1.5 -1.2 0.5 0.7
Comparative body size at age 10 0.8 2.1 2.7 -1.6 1.2 1.6
Number of full brothers 0.2 0.2 0.6 0.8 -0.1 -0.2
Worry too long after embarrassment 2.6 4.4 6.8 -1.5 2.0 2.6
Seen a psychiatrist for nerves, anxiety, tension or depression 4.6 6.0 10.2 -1.1 3.2 2.5
Wheeze or whistling in the chest in last year 0.2 0.3 0.8 0.9 0.1 0.1
Number of children fathered 0.5 0.6 1.3 1.1 0.1 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.0 -1.0 0.2 0.2
Age at first live birth 0.2 0.4 0.8 0.9 -0.3 -0.5
Pulse wave peak to peak time 0.4 0.5 0.9 0.9 -0.7 -0.2
Health satisfaction 0.1 0.1 0.1 -0.3 -0.3 -0.2
Shortness of breath walking on level ground 0.2 0.2 0.7 0.8 -0.1 -0.0
Qualifications: College or University degree 0.2 0.5 0.9 1.0 0.6 0.3
Eye problems/disorders: None of the above 0.9 1.1 1.4 -1.2 0.7 1.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.5 -0.2 -0.1
Emphysema/chronic bronchitis 0.3 0.4 0.6 -0.8 -0.6 -0.4
Medication for pain relief, constipation, heartburn 2.0 3.4 4.4 2.1 -1.6 -1.7
Neck or shoulder pain in last month 2.5 3.6 4.1 -2.0 1.6 2.0
Medication: Blood pressure 1.3 2.3 3.8 -0.7 1.9 1.6
Angina (self-reported) 0.2 0.3 0.4 -0.6 -0.6 -0.2
Migraine (self-reported) 0.1 0.1 0.3 0.5 0.2 0.2
Medication: Ibuprofen 2.3 2.7 5.9 -2.4 0.8 1.3
Medication: Allopurinol 2.7 3.6 4.5 1.5 -2.0 -2.1
Medication: Omeprazole 0.1 0.2 0.2 -0.4 -0.4 -0.4
Medication: Seretide 50 evohaler 0.4 0.4 1.2 -1.1 -0.3 0.0
Mean time to correctly identify matches 0.4 0.7 1.4 -0.2 1.2 0.8
Heart disease (mother) 1.9 2.3 2.8 1.7 -1.4 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.8 0.3 -0.4 -0.9
Whole body fat mass 1.0 4.3 6.7 0.9 -2.6 -2.3
Leg fat mass (right) 0.9 3.4 5.1 0.9 -2.2 -2.1
Arm predicted mass (right) 0.1 0.4 1.0 0.2 -1.0 -0.5
Pulse rate, automated reading 0.8 2.6 5.0 -2.2 1.2 1.1
Alcohol intake frequency. 0.0 0.0 0.1 -0.1 -0.1 -0.2
Comparative height size at age 10 0.2 1.2 2.0 -1.4 -1.3 -0.2
Number of full sisters 0.8 1.0 1.3 1.1 -1.0 -0.8
Suffer from ‘nerves’ 3.7 5.8 8.1 -1.5 2.7 2.9
Overall health rating 0.2 0.5 0.7 0.5 -0.8 -0.8
Chest pain or discomfort 1.6 2.3 2.9 -1.5 1.7 1.4
Had major operations 0.0 0.0 0.0 -0.2 -0.2 0.1
Age at last live birth 0.3 0.4 0.9 1.0 -0.3 -0.6
Family relationship satisfaction 0.8 1.0 1.6 -0.5 1.1 1.2
Leg pain on walking 0.5 0.6 1.3 -0.2 1.1 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.7 0.8 -0.5 -0.7
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.4 1.2 -0.4 -0.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.3 -0.3 -0.3
Medication: Aspirin 0.7 1.0 1.7 -0.8 1.3 0.8
Supplements: Vitamin C 1.4 1.7 2.8 -0.5 1.4 1.7
Knee pain experienced in last month 0.2 0.3 0.7 0.9 0.4 0.0
Hypertension (Self-reported) 4.9 13.5 18.2 -2.8 4.3 3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.3 0.1 0.4 0.6
Illnesses of father: Heart disease 0.4 0.6 1.5 -1.2 -0.1 0.4
Illnesses of siblings: Diabetes 1.1 1.3 1.8 -1.4 1.1 0.9
Smoking status: Previous 1.5 2.3 2.4 -1.5 1.5 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.9 -0.9 -0.2 0.5
Whole body fat-free mass 0.1 0.5 1.2 0.3 -1.1 -0.5
Leg fat-free mass (right) 0.0 0.2 0.6 0.0 -0.8 -0.1
Arm fat percentage (left) 1.1 4.3 6.4 1.1 -2.5 -2.3
Average weekly red wine intake 0.2 0.3 0.5 -0.5 -0.7 -0.2
Handedness (chirality/laterality): Left-handed 4.5 5.4 6.8 -1.7 2.6 2.6
Mood swings 1.8 3.2 4.7 -1.2 1.9 2.2
Loneliness, isolation 5.0 6.9 9.7 -3.1 2.2 2.5
Long-standing illness, disability or infirmity 0.1 0.1 0.3 -0.6 0.1 -0.0
Ever had bowel cancer screening 2.1 2.4 2.9 -1.3 1.7 1.6
Diabetes diagnosed by doctor 0.8 1.3 2.8 1.7 -0.7 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.9 -1.7 0.0 0.8
Friendships satisfaction 0.4 0.5 0.9 0.2 -1.0 -0.6
Qualifications: nursing, teaching 0.3 0.4 0.6 0.6 -0.8 -0.6
Commuting to job workplace: Walk 1.0 1.1 1.5 0.9 -1.2 -1.0
Eye problems/disorders: Cataract 1.8 2.1 2.8 1.1 -1.6 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.6 0.7 -0.7 -0.8
Medication for cholesterol 1.3 1.9 4.4 2.1 -0.9 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 10.5 12.3 13.3 -3.6 3.4 3.4
Back pain experienced in last month 0.0 0.0 0.1 -0.3 -0.1 0.2
Mineral and other dietary supplements 2.0 2.7 4.2 0.9 -2.1 -1.7
Breast cancer (self-reported) 1.3 1.6 1.9 1.4 -1.2 -1.2
Asthma (self-reported) 0.2 0.5 1.2 1.1 0.3 0.3
Osteoporosis (self-reported) 0.5 0.6 1.0 0.6 1.0 0.7
Osteoarthritis (self-reported) 0.5 0.7 0.9 -0.9 0.8 0.7
Medication: Aspirin 0.8 1.0 1.9 -0.7 1.4 0.8
Medication: Gliclazide 1.9 2.2 3.2 0.5 -1.7 -1.8
Illnesses of father: None of the above (group 1) 0.3 0.4 0.5 -0.7 0.7 0.5
Smoking status: Current 3.7 5.9 7.6 -2.8 2.1 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.2 8.8 10.3 2.8 -2.8 -3.2
Whole body water mass 0.1 0.6 1.4 0.3 -1.2 -0.5
Leg predicted mass (right) 0.0 0.2 0.5 -0.0 -0.7 -0.1
Arm fat mass (left) 0.9 3.8 6.0 1.0 -2.5 -2.1
Number of self-reported non-cancer illnesses 0.7 1.2 1.9 -1.4 0.8 1.0
Average weekly champagne plus white wine intake 0.6 0.9 1.5 0.5 1.2 1.0
Miserableness 0.2 0.3 0.5 -0.2 0.7 0.7
Guilty feelings 2.1 3.2 4.2 -1.3 1.9 2.1
Wears glasses or contact lenses 2.5 2.9 4.0 2.0 -1.2 -1.8
Ever taken oral contraceptive pill 1.6 1.7 4.1 -2.0 0.5 1.0
Hearing aid user 2.2 2.5 3.4 1.1 -1.8 -1.7
Mother’s age at death 0.2 0.2 0.4 0.6 -0.1 -0.6
Financial situation satisfaction 0.9 1.2 1.9 -1.4 0.8 0.9
Tinnitus: Yes, now most or all of the time 1.2 1.4 1.8 -1.3 1.1 1.1
Commuting to job workplace: Public transport 0.1 0.1 0.3 -0.5 -0.3 -0.2
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 -0.5 0.0 0.0
Medication: Blood pressure 0.6 1.1 2.0 -0.5 1.4 1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.4 -1.2 0.7 0.9
Supplements: Fish oil (including cod liver oil) 1.6 2.1 3.9 -0.1 2.0 1.5
High cholesterol (Self-reported) 2.7 4.7 6.1 -2.5 2.0 2.0
Medication: Bendroflumethiazide 1.4 2.1 2.8 -0.9 1.7 1.6
Medication: Paracetamol 0.1 0.2 0.3 -0.5 -0.5 -0.3
Medication: Lisinopril 3.4 4.5 5.0 -2.0 2.2 2.1
Medication: Atorvastatin 0.3 0.3 0.7 -0.4 -0.4 -0.9
Illnesses of father: High blood pressure 1.0 1.2 2.4 0.3 1.6 1.1
Alcohol drinker status: Never 0.1 0.2 0.4 -0.6 -0.0 0.3
Ever smoked 1.0 1.7 2.1 -0.9 1.5 1.5
Basal metabolic rate 0.2 1.0 2.1 0.4 -1.5 -0.8
Leg fat percentage (left) 0.7 2.7 3.7 1.2 -1.7 -1.9
Arm fat-free mass (left) 0.1 0.3 0.7 0.3 -0.8 -0.3
Number of operations (self-reported) 0.4 0.6 1.3 -1.1 0.5 0.6
Average weekly beer plus cider intake 0.6 0.8 1.3 -0.4 1.1 1.0
Irritability 1.2 2.1 2.8 -0.9 1.6 1.7
Risk taking 2.5 3.6 6.1 -2.5 1.3 1.8
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.4 0.3 0.3
Fractured/broken bones in last 5 years 3.3 4.3 5.0 2.0 -2.2 -2.0
Age started oral contraceptive pill 0.8 1.1 2.9 1.7 -0.2 -0.5
Diastolic blood pressure, automated reading 0.0 0.1 0.1 -0.3 -0.3 -0.4
Ever depressed for a whole week 0.8 1.0 1.4 -0.5 1.1 1.2
Unable to work because of sickness or disability 1.1 1.5 1.7 -1.2 1.2 1.3
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.2 -0.8 -0.4
Myopia 0.6 0.8 1.9 1.4 -0.4 -0.7
Vascular/heart problems diagnosed by doctor 5.7 15.5 19.0 3.5 -4.4 -3.9
Cholesterol lowering medication 0.3 0.4 0.6 -0.6 0.8 0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.4 0.0 -0.7 -0.7
Pain experienced in last month 0.7 1.2 1.6 -1.1 0.9 1.3
Supplements: Calcium 1.5 1.7 2.3 -1.0 1.5 1.3
Basal cell carcinoma (self-reported) 0.2 0.3 0.5 -0.5 0.7 0.4
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.3 -1.1 -0.1 0.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 1.4 -1.1 -1.2 -0.9
Heart disease (siblings) 2.7 3.3 4.5 2.1 -1.5 -1.7
Alcohol drinker status: Previous 0.9 1.0 1.5 0.4 -1.2 -1.1
Pack years of smoking 0.3 0.4 0.5 -0.7 0.4 0.7
Impedance of whole body 0.0 0.2 0.5 -0.1 -0.4 -0.7
Leg fat mass (left) 0.8 3.2 4.7 0.9 -2.2 -2.0
Arm predicted mass (left) 0.1 0.3 0.7 0.4 -0.8 -0.3