Hub : Genes

THAP9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0718	0.0327	5.7e-03	0.006	NA	-0.003	NA	0.007	0.1200	NA	0.64000	NA	0.10000
2	TCGA	Brain Lower Grade Glioma	0.0259	0.0191	6.1e-03	0.029	0.022	0.022	NA	0.025	0.0003	1.5e-03	0.00130	NA	0.00072
3	TCGA	Prostate Adenocarcinoma	0.0438	0.0256	4.5e-05	0.036	0.037	0.036	NA	0.035	0.0001	7.8e-05	0.00011	NA	0.00014

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	2.0	-1.4	0.7	0.6
Bipolar Disorder or Schizophrenia	2.5	6.2	6.7	-2.6	2.6	2.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	-0.0	-0.0	0.1
Depression (Nagel 2018)	0.2	0.2	0.4	-0.7	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.5	2.3	-0.6	-0.7
Neuroticism (Nagel 2018)	1.9	4.4	5.4	-1.6	2.3	2.3
Schizophrenia (2018)	3.0	6.2	7.6	-2.2	2.8	2.5
Schizophrenia vs Biploar Disorder	1.9	2.4	3.2	-1.5	1.3	1.8
Worry (Nagel 2018)	5.5	11.5	13.4	-2.9	3.7	3.5
Alzheimer’s Disease (in mother)	1.0	1.1	1.7	-0.1	-1.3	-1.3
Alzheimer’s Disease (in father)	0.4	0.5	0.6	0.8	0.8	0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	0.4	-0.9	-0.9
Crohns Disease (2017)	1.5	3.4	5.3	-0.3	2.3	2.2
Irritable Bowel Disease (IBD)	2.2	5.1	8.2	-0.5	2.9	2.6
Ulcerative Colitis (UC)	1.6	2.9	4.8	-0.5	2.2	1.9
Major Depression (MDD)	3.5	4.2	6.2	-2.5	1.8	1.8
Reaction Time	0.4	0.8	1.0	-0.6	1.0	1.0
Verbal and Numeric Reasoning (VNR)	2.1	5.1	5.4	2.2	-2.3	-2.3
Breast Cancer	4.1	9.8	13.5	-3.7	2.7	3.0
Ovarian Cancer	5.5	7.2	9.2	2.6	-2.4	-3.0
Prostate Cancer	0.7	0.9	1.8	0.4	1.3	1.0
Age at First Birth	1.0	1.4	3.5	1.9	-0.3	-0.8
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.5	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	0.4	0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.1	-0.1	-0.2	-0.1
Crohns Disease (2012)	0.5	0.8	1.4	0.0	1.2	1.0
Mean Putamen Volume	1.6	1.9	2.4	-1.2	1.5	1.3
Fasting Glucose	1.2	1.5	2.7	-0.6	1.6	1.1
HbA1C	0.8	0.9	1.2	0.6	-1.1	-1.0
HDL Cholesterol	3.8	6.4	8.9	-1.4	3.0	2.9
LDL Cholesterol	0.2	0.3	0.5	0.0	-0.6	-0.7
Lupus	2.2	3.3	4.5	-1.1	2.1	2.1
Neuroticism (2016)	1.6	2.4	3.2	-1.6	1.1	1.8
Primary Biliary Cirrhosis	0.8	1.1	1.6	-1.3	0.9	1.0
Rheumatoid Arthritis	0.4	0.5	0.8	0.1	-0.8	-0.9
Schizophrenia (2014)	2.6	5.7	6.6	-2.1	2.5	2.6
Triglycerides	1.0	1.6	3.6	-1.9	0.8	0.8
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.6	1.6	-0.5	-0.7
Ulcerative Colitis	2.6	3.8	5.3	-1.0	2.3	2.3
Blood Eosinophil Count	2.8	21.5	37.1	0.9	-6.1	-5.1
Blood Platelet Count	0.6	6.8	11.3	3.4	2.7	1.3
Blood Red Count	0.7	6.7	15.4	-3.9	-2.1	-0.4
Blood White Count	2.8	20.7	35.9	1.3	-6.0	-5.0
Heel T-Score	0.1	0.4	0.6	0.6	-0.7	-0.7
BMI	0.8	4.4	5.4	1.8	-2.3	-2.2
Height	0.3	5.1	9.4	0.5	-3.1	-2.4
Waist Hip Ratio (WHR)	0.4	1.8	2.5	1.3	-1.6	-1.2
Systolic Blood Pressure	3.0	15.1	23.0	-2.6	4.8	3.9
Smoking Status	3.4	8.1	11.6	-3.4	2.3	2.8
Allergy or Eczema	0.0	0.0	0.0	0.1	-0.1	-0.2
Cardiovascular Disease	7.0	23.3	24.4	-4.8	4.9	4.7
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.0	-0.8	-0.6
Respiratory disease	0.1	0.3	0.5	0.4	-0.7	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	0.5	-0.0	-0.1
Lung FEV1/FVC ratio	4.2	21.5	22.1	4.6	-4.6	-4.7
Lung FVC	0.1	0.6	1.6	1.3	0.1	-0.1
Neuroticism	2.6	6.4	7.4	-2.4	2.5	2.7
Chronotype (morning person)	1.1	2.6	5.6	0.4	-2.4	-1.4
Hair Pigment	0.0	0.8	1.1	-1.1	0.6	0.9
Tanning	0.0	0.1	0.2	0.5	-0.2	-0.4
Hand grip strength (left)	0.0	0.1	0.3	-0.1	0.3	0.5
Number of treatments/medications taken	1.2	2.1	3.2	-1.8	1.2	1.3
Average weekly spirits intake	3.6	4.5	7.2	1.2	-2.7	-2.2
Sensitivity / hurt feelings	1.0	1.7	2.5	-1.6	0.9	1.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.2	0.4	0.6
Hearing difficulty/problems: Yes	1.4	2.1	3.1	0.9	-1.5	-1.8
Relative age of first facial hair	0.9	1.8	2.6	-0.9	1.6	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.4	0.2	-1.3	-1.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-1.3	0.7	0.8
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	0.2	-0.4	-0.1
Systolic blood pressure, automated reading	1.2	3.5	6.4	-0.9	2.5	1.9
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.0	0.3	0.2
Angina	0.3	0.3	0.6	-0.6	-0.8	-0.4
Medication for hormone replacement therapy	2.0	2.3	6.7	-2.6	0.2	0.3
Vitamin and mineral supplements	0.2	0.3	0.7	0.1	-0.9	-0.5
Supplements: Zinc	1.3	1.4	1.8	-0.8	1.4	1.2
Medication: Co-codamol	0.2	0.3	0.6	0.8	0.4	0.2
Medication: Metformin	0.3	0.4	1.0	1.0	-0.1	-0.3
Diabetes (father)	0.5	0.6	1.5	-0.1	-1.2	-0.4
Diabetes (mother)	0.4	0.5	0.8	0.5	-0.9	-0.7
Severe depression (siblings)	0.6	0.7	1.2	-0.1	1.1	1.0
Pack years adult smoking proportion	0.4	0.6	0.8	-0.9	0.5	0.9
Impedance of leg (right)	0.1	0.3	0.6	-0.1	-0.4	-0.8
Leg fat-free mass (left)	0.1	0.6	1.5	-0.0	-1.2	-0.5
Trunk fat percentage	1.2	4.9	7.4	1.0	-2.7	-2.5
Hand grip strength (right)	0.0	0.1	0.2	0.2	-0.4	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	0.3	0.4
Current tobacco smoking	3.7	6.0	8.6	-2.9	2.0	2.4
Average weekly fortified wine intake	0.7	0.8	1.3	0.1	-1.2	-1.0
Maternal smoking around birth	0.4	0.6	0.9	0.4	-1.0	-0.9
Fed-up feelings	0.2	0.4	1.0	-1.0	0.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.4	-1.2	0.5	0.8
Relative age voice broke	0.3	0.4	1.0	-1.0	-0.1	-0.5
Taking other prescription medications	0.0	0.0	0.1	-0.1	-0.0	-0.3
Age when periods started (menarche)	0.2	0.4	1.2	-1.1	0.1	-0.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	0.2	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.8	0.8	-1.7	-1.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.1	0.6	0.6
Qualifications: CSEs or equivalent	0.2	0.2	0.3	-0.6	-0.5	-0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.0	1.0	-0.2	-0.6
High blood pressure	5.1	14.2	18.7	-3.0	4.3	3.8
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.1	-0.1	-0.1
Multivitamins +/- minerals	0.6	0.8	1.2	-0.9	1.1	0.6
Stomach or abdominal pain in last month	0.6	0.7	2.1	-1.4	-0.0	0.0
Supplements: Glucosamine	1.6	2.1	4.2	0.1	2.0	1.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.9	-0.3	-0.3
Medication: Atenolol	0.5	0.6	0.7	-0.7	0.8	0.8
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.5	0.3	0.6
Sitting height	0.2	1.3	1.9	-1.4	0.6	1.3
Chronic bronchitis/emphysema (father)	2.8	3.3	3.9	-1.5	1.9	2.0
High blood pressure (mother)	1.2	1.6	2.9	0.5	1.7	1.3
Body mass index (BMI)	0.7	2.8	3.6	1.3	-1.9	-1.7
Impedance of leg (left)	0.0	0.0	0.1	-0.1	0.0	-0.4
Leg predicted mass (left)	0.1	0.5	1.2	-0.0	-1.1	-0.4
Trunk fat mass	1.2	5.3	8.2	1.1	-2.9	-2.5
Waist circumference	1.6	5.9	8.4	1.7	-2.9	-2.5
Number of incorrect matches in round	0.2	0.3	0.4	-0.3	0.7	0.6
Past tobacco smoking	1.7	3.2	3.4	1.7	-1.8	-1.8
Alcohol usually taken with meals	0.4	0.6	1.2	-1.1	0.6	0.6
Nervous feelings	2.2	4.1	4.7	-1.8	2.0	2.2
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.8	8.9	-2.2	2.6	3.0
Hearing difficulty/problems with background noise	0.4	0.6	0.8	-0.5	0.9	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.3	0.8	0.6
Had menopause	0.3	0.3	0.8	0.9	-0.2	-0.4
Had other major operations	0.3	0.4	0.5	-0.7	0.6	0.5
Forced vital capacity (FVC)	0.3	1.2	1.6	0.9	-1.3	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	0.5	-0.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.4	-0.5	1.2	1.0
Qualifications: None of the above	0.6	1.2	1.5	-1.2	0.8	1.2
Financial difficulties in last 2 years	0.7	0.9	1.4	0.1	-1.1	-1.2
Mouth/teeth dental problems	0.0	0.0	0.0	0.2	-0.2	0.0
Heart attack	0.7	0.9	1.9	-1.4	0.4	0.8
Allergy	0.0	0.0	0.0	0.2	0.2	-0.1
Pain all over the body in last month	0.3	0.3	0.6	0.7	-0.1	-0.5
Diabetes (self-reported)	1.2	1.9	2.9	1.7	-1.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.4	-0.3	0.1
Medication: Ramipril	0.9	1.2	3.4	1.8	0.1	-0.4
Medication: Simvastatin	1.0	1.5	1.9	-0.9	1.4	1.3
Fluid intelligence score	0.4	0.9	1.9	1.4	-0.5	-0.8
Illnesses of siblings	0.3	0.5	0.7	-0.4	-0.8	-0.7
Neuroticism score	6.0	12.4	15.8	-3.1	3.5	4.0
Weight	0.6	2.9	4.8	0.9	-2.2	-1.8
Impedance of arm (right)	0.1	0.5	0.6	-0.5	-0.8	-0.7
Arm fat percentage (right)	1.0	4.1	6.3	1.0	-2.5	-2.2
Trunk fat-free mass	0.1	0.5	1.2	0.3	-1.1	-0.5
Hip circumference	1.1	4.6	7.1	1.2	-2.7	-2.3
Time employed in main current job	0.9	1.0	1.3	-1.1	0.7	1.1
Alcohol intake versus 10 years previously	1.8	2.7	5.5	2.4	-0.9	-1.4
Father’s age at death	0.8	1.1	2.2	0.1	1.5	1.0
Worrier / anxious feelings	4.4	8.3	9.8	-2.5	2.9	3.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.3	-0.1	0.2
Falls in the last year	0.8	1.1	1.3	0.9	-1.1	-1.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.0	-1.0	0.9	0.6
Number of live births	2.4	3.4	4.5	-1.2	2.1	2.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	5.3	1.9	-2.3	-2.2
Pulse rate	0.8	1.4	2.6	-1.6	1.1	0.8
Happiness	1.8	2.2	3.2	-1.8	1.1	1.5
Noisy workplace	0.3	0.3	0.7	-0.9	-0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.6	1.3	-0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.2	0.5	0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	-0.3	0.5	0.4
Asthma	0.2	0.3	0.9	1.0	0.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	4.8	-2.2	1.4	1.7
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.4	0.4	0.6
Depression (self-reported)	0.0	0.0	0.1	-0.2	0.2	0.0
Medication: Lansoprazole	0.9	1.0	2.8	1.7	-0.4	-0.4
Prospective memory result	0.3	0.4	0.9	1.0	-0.3	-0.3
Lung cancer (father)	0.2	0.3	0.7	-0.9	-0.3	-0.1
Illnesses of mother	1.2	1.5	1.8	-1.2	1.1	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	7.1	2.5	-2.7	-2.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	-1.1	0.5	0.1
Impedance of arm (left)	0.1	0.5	0.8	-0.2	-0.9	-0.9
Arm fat mass (right)	0.9	3.8	6.2	0.9	-2.5	-2.1
Trunk predicted mass	0.1	0.6	1.4	0.4	-1.2	-0.6
Standing height	0.1	0.6	1.2	-0.5	-1.1	-0.4
Length of working week for main job	0.7	0.7	1.3	0.2	-1.2	-0.9
Exposure to tobacco smoke at home	0.1	0.1	0.4	-0.2	-0.6	0.2
Breastfed as a baby	0.1	0.1	0.1	0.3	-0.3	-0.3
Tense / ‘highly strung’	8.4	13.9	14.4	-3.6	3.8	3.8
Seen doctor (GP) for nerves, anxiety, tension or depression	4.5	6.9	9.0	-3.0	2.3	2.5
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.3	0.7	0.2
Birth weight of first child	0.1	0.3	0.3	0.5	0.5	0.4
Peak expiratory flow (PEF)	3.6	8.3	8.4	2.9	-2.9	-2.9
Pulse wave reflection index	0.0	0.0	0.1	0.2	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	0.1	0.4
Loud music exposure frequency	2.8	3.1	4.5	-1.3	1.7	2.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.3	1.1	-1.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.8	0.2	-0.3	-0.9
Blood clot in the leg (DVT)	0.8	1.1	1.6	-1.3	-1.0	-0.7
Medication: Paracetamol	0.9	1.5	2.0	-1.2	1.1	1.4
Headache pain in last month	0.1	0.1	0.4	-0.6	0.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.4	1.1	-1.2	-1.2
Glaucoma (self-reported)	0.0	0.0	0.1	-0.2	0.1	0.1
Gout (self-reported)	2.5	3.5	4.8	2.2	-1.6	-1.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.1	-0.1	0.1
Medication: Amlodipine	3.0	4.2	5.5	-1.3	2.3	2.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.1	-0.2	-0.8
Birth weight	0.4	0.8	1.0	-0.8	1.0	0.9
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.0	-0.3	-0.3
High blood pressure (siblings)	1.0	1.5	1.8	1.3	1.3	1.0
Forced vital capacity (FVC), Best measure	0.7	2.5	3.0	1.6	-1.7	-1.4
Body fat percentage	1.2	4.6	6.5	1.1	-2.5	-2.4
Leg fat percentage (right)	0.9	3.3	4.4	1.2	-2.0	-2.1
Arm fat-free mass (right)	0.1	0.3	0.8	0.3	-0.9	-0.4
Exposure to tobacco smoke outside home	0.6	0.7	1.5	-1.2	0.5	0.7
Comparative body size at age 10	0.8	2.1	2.7	-1.6	1.2	1.6
Number of full brothers	0.2	0.2	0.6	0.8	-0.1	-0.2
Worry too long after embarrassment	2.6	4.4	6.8	-1.5	2.0	2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	4.6	6.0	10.2	-1.1	3.2	2.5
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.9	0.1	0.1
Number of children fathered	0.5	0.6	1.3	1.1	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-1.0	0.2	0.2
Age at first live birth	0.2	0.4	0.8	0.9	-0.3	-0.5
Pulse wave peak to peak time	0.4	0.5	0.9	0.9	-0.7	-0.2
Health satisfaction	0.1	0.1	0.1	-0.3	-0.3	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.7	0.8	-0.1	-0.0
Qualifications: College or University degree	0.2	0.5	0.9	1.0	0.6	0.3
Eye problems/disorders: None of the above	0.9	1.1	1.4	-1.2	0.7	1.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.5	-0.2	-0.1
Emphysema/chronic bronchitis	0.3	0.4	0.6	-0.8	-0.6	-0.4
Medication for pain relief, constipation, heartburn	2.0	3.4	4.4	2.1	-1.6	-1.7
Neck or shoulder pain in last month	2.5	3.6	4.1	-2.0	1.6	2.0
Medication: Blood pressure	1.3	2.3	3.8	-0.7	1.9	1.6
Angina (self-reported)	0.2	0.3	0.4	-0.6	-0.6	-0.2
Migraine (self-reported)	0.1	0.1	0.3	0.5	0.2	0.2
Medication: Ibuprofen	2.3	2.7	5.9	-2.4	0.8	1.3
Medication: Allopurinol	2.7	3.6	4.5	1.5	-2.0	-2.1
Medication: Omeprazole	0.1	0.2	0.2	-0.4	-0.4	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	1.2	-1.1	-0.3	0.0
Mean time to correctly identify matches	0.4	0.7	1.4	-0.2	1.2	0.8
Heart disease (mother)	1.9	2.3	2.8	1.7	-1.4	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.3	-0.4	-0.9
Whole body fat mass	1.0	4.3	6.7	0.9	-2.6	-2.3
Leg fat mass (right)	0.9	3.4	5.1	0.9	-2.2	-2.1
Arm predicted mass (right)	0.1	0.4	1.0	0.2	-1.0	-0.5
Pulse rate, automated reading	0.8	2.6	5.0	-2.2	1.2	1.1
Alcohol intake frequency.	0.0	0.0	0.1	-0.1	-0.1	-0.2
Comparative height size at age 10	0.2	1.2	2.0	-1.4	-1.3	-0.2
Number of full sisters	0.8	1.0	1.3	1.1	-1.0	-0.8
Suffer from ‘nerves’	3.7	5.8	8.1	-1.5	2.7	2.9
Overall health rating	0.2	0.5	0.7	0.5	-0.8	-0.8
Chest pain or discomfort	1.6	2.3	2.9	-1.5	1.7	1.4
Had major operations	0.0	0.0	0.0	-0.2	-0.2	0.1
Age at last live birth	0.3	0.4	0.9	1.0	-0.3	-0.6
Family relationship satisfaction	0.8	1.0	1.6	-0.5	1.1	1.2
Leg pain on walking	0.5	0.6	1.3	-0.2	1.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	0.8	-0.5	-0.7
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	1.2	-0.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.3	-0.3	-0.3
Medication: Aspirin	0.7	1.0	1.7	-0.8	1.3	0.8
Supplements: Vitamin C	1.4	1.7	2.8	-0.5	1.4	1.7
Knee pain experienced in last month	0.2	0.3	0.7	0.9	0.4	0.0
Hypertension (Self-reported)	4.9	13.5	18.2	-2.8	4.3	3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.1	0.4	0.6
Illnesses of father: Heart disease	0.4	0.6	1.5	-1.2	-0.1	0.4
Illnesses of siblings: Diabetes	1.1	1.3	1.8	-1.4	1.1	0.9
Smoking status: Previous	1.5	2.3	2.4	-1.5	1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.9	-0.9	-0.2	0.5
Whole body fat-free mass	0.1	0.5	1.2	0.3	-1.1	-0.5
Leg fat-free mass (right)	0.0	0.2	0.6	0.0	-0.8	-0.1
Arm fat percentage (left)	1.1	4.3	6.4	1.1	-2.5	-2.3
Average weekly red wine intake	0.2	0.3	0.5	-0.5	-0.7	-0.2
Handedness (chirality/laterality): Left-handed	4.5	5.4	6.8	-1.7	2.6	2.6
Mood swings	1.8	3.2	4.7	-1.2	1.9	2.2
Loneliness, isolation	5.0	6.9	9.7	-3.1	2.2	2.5
Long-standing illness, disability or infirmity	0.1	0.1	0.3	-0.6	0.1	-0.0
Ever had bowel cancer screening	2.1	2.4	2.9	-1.3	1.7	1.6
Diabetes diagnosed by doctor	0.8	1.3	2.8	1.7	-0.7	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.9	-1.7	0.0	0.8
Friendships satisfaction	0.4	0.5	0.9	0.2	-1.0	-0.6
Qualifications: nursing, teaching	0.3	0.4	0.6	0.6	-0.8	-0.6
Commuting to job workplace: Walk	1.0	1.1	1.5	0.9	-1.2	-1.0
Eye problems/disorders: Cataract	1.8	2.1	2.8	1.1	-1.6	-1.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.6	0.7	-0.7	-0.8
Medication for cholesterol	1.3	1.9	4.4	2.1	-0.9	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	10.5	12.3	13.3	-3.6	3.4	3.4
Back pain experienced in last month	0.0	0.0	0.1	-0.3	-0.1	0.2
Mineral and other dietary supplements	2.0	2.7	4.2	0.9	-2.1	-1.7
Breast cancer (self-reported)	1.3	1.6	1.9	1.4	-1.2	-1.2
Asthma (self-reported)	0.2	0.5	1.2	1.1	0.3	0.3
Osteoporosis (self-reported)	0.5	0.6	1.0	0.6	1.0	0.7
Osteoarthritis (self-reported)	0.5	0.7	0.9	-0.9	0.8	0.7
Medication: Aspirin	0.8	1.0	1.9	-0.7	1.4	0.8
Medication: Gliclazide	1.9	2.2	3.2	0.5	-1.7	-1.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	-0.7	0.7	0.5
Smoking status: Current	3.7	5.9	7.6	-2.8	2.1	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.2	8.8	10.3	2.8	-2.8	-3.2
Whole body water mass	0.1	0.6	1.4	0.3	-1.2	-0.5
Leg predicted mass (right)	0.0	0.2	0.5	-0.0	-0.7	-0.1
Arm fat mass (left)	0.9	3.8	6.0	1.0	-2.5	-2.1
Number of self-reported non-cancer illnesses	0.7	1.2	1.9	-1.4	0.8	1.0
Average weekly champagne plus white wine intake	0.6	0.9	1.5	0.5	1.2	1.0
Miserableness	0.2	0.3	0.5	-0.2	0.7	0.7
Guilty feelings	2.1	3.2	4.2	-1.3	1.9	2.1
Wears glasses or contact lenses	2.5	2.9	4.0	2.0	-1.2	-1.8
Ever taken oral contraceptive pill	1.6	1.7	4.1	-2.0	0.5	1.0
Hearing aid user	2.2	2.5	3.4	1.1	-1.8	-1.7
Mother’s age at death	0.2	0.2	0.4	0.6	-0.1	-0.6
Financial situation satisfaction	0.9	1.2	1.9	-1.4	0.8	0.9
Tinnitus: Yes, now most or all of the time	1.2	1.4	1.8	-1.3	1.1	1.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	-0.3	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.5	0.0	0.0
Medication: Blood pressure	0.6	1.1	2.0	-0.5	1.4	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.4	-1.2	0.7	0.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.9	-0.1	2.0	1.5
High cholesterol (Self-reported)	2.7	4.7	6.1	-2.5	2.0	2.0
Medication: Bendroflumethiazide	1.4	2.1	2.8	-0.9	1.7	1.6
Medication: Paracetamol	0.1	0.2	0.3	-0.5	-0.5	-0.3
Medication: Lisinopril	3.4	4.5	5.0	-2.0	2.2	2.1
Medication: Atorvastatin	0.3	0.3	0.7	-0.4	-0.4	-0.9
Illnesses of father: High blood pressure	1.0	1.2	2.4	0.3	1.6	1.1
Alcohol drinker status: Never	0.1	0.2	0.4	-0.6	-0.0	0.3
Ever smoked	1.0	1.7	2.1	-0.9	1.5	1.5
Basal metabolic rate	0.2	1.0	2.1	0.4	-1.5	-0.8
Leg fat percentage (left)	0.7	2.7	3.7	1.2	-1.7	-1.9
Arm fat-free mass (left)	0.1	0.3	0.7	0.3	-0.8	-0.3
Number of operations (self-reported)	0.4	0.6	1.3	-1.1	0.5	0.6
Average weekly beer plus cider intake	0.6	0.8	1.3	-0.4	1.1	1.0
Irritability	1.2	2.1	2.8	-0.9	1.6	1.7
Risk taking	2.5	3.6	6.1	-2.5	1.3	1.8
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.4	0.3	0.3
Fractured/broken bones in last 5 years	3.3	4.3	5.0	2.0	-2.2	-2.0
Age started oral contraceptive pill	0.8	1.1	2.9	1.7	-0.2	-0.5
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.3	-0.3	-0.4
Ever depressed for a whole week	0.8	1.0	1.4	-0.5	1.1	1.2
Unable to work because of sickness or disability	1.1	1.5	1.7	-1.2	1.2	1.3
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.2	-0.8	-0.4
Myopia	0.6	0.8	1.9	1.4	-0.4	-0.7
Vascular/heart problems diagnosed by doctor	5.7	15.5	19.0	3.5	-4.4	-3.9
Cholesterol lowering medication	0.3	0.4	0.6	-0.6	0.8	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	0.0	-0.7	-0.7
Pain experienced in last month	0.7	1.2	1.6	-1.1	0.9	1.3
Supplements: Calcium	1.5	1.7	2.3	-1.0	1.5	1.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.5	0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.3	-1.1	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.4	-1.1	-1.2	-0.9
Heart disease (siblings)	2.7	3.3	4.5	2.1	-1.5	-1.7
Alcohol drinker status: Previous	0.9	1.0	1.5	0.4	-1.2	-1.1
Pack years of smoking	0.3	0.4	0.5	-0.7	0.4	0.7
Impedance of whole body	0.0	0.2	0.5	-0.1	-0.4	-0.7
Leg fat mass (left)	0.8	3.2	4.7	0.9	-2.2	-2.0
Arm predicted mass (left)	0.1	0.3	0.7	0.4	-0.8	-0.3