Hub : Genes

SCD5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2840	0.0370	0.0e+00	0.400	0.348	0.411	0.399	0.410	4.7e-52	5.6e-44	5.8e-54	6.8e-52	9.8e-54
2	GTEx	Brain Putamen basal ganglia	0.3460	0.1160	3.4e-03	0.053	NA	0.051	NA	0.013	2.2e-02	NA	2.4e-02	NA	1.6e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.3130	0.1050	1.2e-04	0.112	NA	0.110	NA	0.094	1.7e-04	NA	1.9e-04	NA	5.6e-04
4	GTEx	Cells Transformed fibroblasts	0.1740	0.0420	5.7e-08	0.025	NA	0.116	NA	0.130	5.5e-03	NA	5.0e-09	NA	5.4e-10
5	GTEx	Esophagus Mucosa	0.1010	0.0380	2.3e-03	0.035	NA	0.053	NA	0.058	2.2e-03	NA	1.9e-04	NA	9.7e-05
6	GTEx	Whole Blood	0.1090	0.0400	5.9e-04	0.018	NA	0.013	NA	0.009	8.4e-03	NA	2.0e-02	NA	4.9e-02
7	METSIM	Adipose	0.1145	0.0270	2.4e-11	0.051	0.088	0.094	0.076	0.057	3.5e-08	4.5e-13	5.8e-14	2.0e-11	5.5e-09
8	NTR	Blood	0.0413	0.0119	4.7e-09	0.035	0.028	0.032	0.035	0.029	2.1e-11	1.7e-09	1.5e-10	2.2e-11	8.0e-10
9	ROSMAP	Brain Pre-frontal Cortex	0.2186	0.0394	0.0e+00	0.147	0.148	0.146	0.155	0.166	1.7e-18	1.4e-18	2.8e-18	2.0e-19	7.8e-21
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1710	0.0730	8.4e-03	0.102	0.036	0.084	NA	0.101	1.9e-06	3.7e-03	1.6e-05	NA	2.1e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	2.0	-0.9	-0.6	0.1	0.6	1.2	0.1	-0.7	-0.8	-0.2	-1.4
Bipolar Disorder or Schizophrenia	1.1	2.6	10.3	0.2	-1.1	-1.5	1.0	3.2	-1.4	-0.9	-2.1	-1.2	-1.5
Depressed Affect (Nagel 2018)	0.4	0.9	6.1	0.7	-0.2	-0.1	-0.6	0.8	-0.1	-0.5	0.2	-2.5	-0.7
Depression (Nagel 2018)	0.5	0.7	4.0	0.4	2.0	-0.3	0.0	0.0	-0.4	-1.0	0.4	-0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.4	1.1	-0.7	-0.1	-0.5	-0.4	-0.0	-1.2	0.6	-0.9	0.3
Neuroticism (Nagel 2018)	1.2	2.9	5.7	1.2	-0.2	-2.0	0.6	2.4	-2.0	-2.0	-1.5	-2.4	-1.3
Schizophrenia (2018)	1.3	2.7	9.9	0.9	-1.1	-2.0	0.8	3.1	-1.9	-0.6	-2.1	-1.3	-0.8
Schizophrenia vs Biploar Disorder	1.4	1.9	5.9	0.4	0.7	-1.9	1.2	2.4	-1.8	-0.9	-1.7	0.6	-0.1
Worry (Nagel 2018)	1.8	3.9	8.1	0.4	0.2	-2.8	1.9	2.5	-2.8	-2.7	-2.3	-0.6	-0.1
Alzheimer’s Disease (in mother)	1.6	1.9	3.8	0.6	1.8	1.9	-1.7	0.1	1.9	0.1	1.9	0.1	0.9
Alzheimer’s Disease (in father)	0.6	0.6	1.8	-1.3	-0.3	-0.9	1.3	0.8	-0.9	0.1	-0.2	-0.2	0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	2.4	-0.6	0.9	1.0	-0.5	0.5	1.0	0.8	1.5	-0.7	0.7
Crohns Disease (2017)	1.6	3.4	9.2	-0.2	-1.9	-2.4	2.0	3.0	-2.4	-0.5	-2.2	-0.3	0.3
Irritable Bowel Disease (IBD)	2.4	5.6	11.9	-1.3	-2.3	-3.1	3.1	3.4	-2.9	-0.9	-2.8	0.8	0.2
Ulcerative Colitis (UC)	2.0	3.8	8.6	-1.9	-1.4	-2.2	2.9	2.4	-2.1	-0.7	-2.2	1.8	-0.4
Major Depression (MDD)	2.4	2.9	7.3	-0.9	2.3	-1.2	1.6	2.7	-1.0	-2.1	-1.4	1.8	-0.7
Reaction Time	0.7	1.2	3.4	-1.6	0.4	-0.8	1.9	-1.5	-0.8	0.6	-1.0	1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.4	-0.4	0.3	1.7	-0.8	-1.9	1.7	-0.6	2.1	0.1	0.9
Breast Cancer	0.9	2.1	5.5	2.0	1.0	-2.1	-0.1	0.9	-2.3	1.1	-1.3	-1.5	0.4
Ovarian Cancer	3.5	4.6	10.0	-0.6	-2.2	3.1	-2.0	-2.0	3.2	1.8	2.7	-0.5	1.6
Prostate Cancer	0.8	1.1	5.2	1.0	-0.0	-1.3	0.3	0.4	-1.2	0.3	-0.9	-0.8	-2.3
Age at First Birth	1.1	1.6	6.8	1.8	-1.4	0.4	-1.2	-2.6	0.4	0.0	0.5	-1.1	0.5
Bipolar Disorder (2011)	1.4	1.4	4.9	0.2	0.7	-1.2	0.8	1.3	-1.3	-1.2	-1.1	-0.4	-2.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	0.1	-1.2	-0.7	0.6	0.1	-0.8	0.6	-0.5	-0.5	0.3
Coronary Artery Disease (CAD)	0.5	0.6	1.9	1.3	0.5	0.1	-1.1	-0.6	0.1	-0.6	0.5	-0.2	-1.4
Crohns Disease (2012)	0.7	1.1	3.2	-0.2	0.1	-1.1	1.1	1.8	-1.1	-0.8	-1.0	-0.5	-1.3
Mean Putamen Volume	1.2	1.4	3.2	-0.9	0.8	-0.8	1.6	1.0	-0.9	-1.8	-1.3	1.6	0.2
Fasting Glucose	0.4	0.5	1.3	0.9	-0.0	-1.0	-0.0	1.1	-0.9	0.6	-0.6	-0.1	0.1
HbA1C	0.4	0.4	1.9	-0.9	-0.1	0.6	0.3	0.0	0.5	0.1	0.5	1.4	0.5
HDL Cholesterol	3.1	5.1	10.2	-0.8	-0.7	-3.0	3.2	2.3	-2.9	-2.5	-3.0	1.1	0.3
LDL Cholesterol	0.7	1.1	2.5	1.1	-1.2	0.7	-1.6	-0.5	0.8	-1.0	1.0	-1.5	-0.2
Lupus	1.0	1.5	4.0	0.5	0.6	-2.0	0.9	0.8	-2.0	-1.1	-1.6	-0.5	-0.8
Neuroticism (2016)	1.3	1.9	5.2	-0.1	1.2	-1.8	1.0	1.4	-1.9	-2.3	-1.6	0.1	-0.1
Primary Biliary Cirrhosis	1.4	1.9	7.0	-1.5	-1.2	-0.6	1.5	2.7	-0.6	-1.6	-1.0	1.5	0.1
Rheumatoid Arthritis	0.5	0.7	1.9	-1.0	1.0	1.0	0.1	-0.7	1.0	-0.5	1.4	0.3	0.4
Schizophrenia (2014)	1.6	3.5	13.7	-0.0	-0.3	-2.3	1.6	3.7	-2.1	-0.6	-2.7	-0.8	-1.1
Triglycerides	0.4	0.7	1.8	1.1	0.5	-0.1	-1.2	0.9	-0.1	-0.2	0.3	-1.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.2	1.0	0.2	0.4	-1.1	-1.1	0.3	-0.7	0.7	-0.1	-0.4
Ulcerative Colitis	2.2	3.2	7.5	-0.7	-0.6	-2.7	2.5	2.2	-2.6	-1.3	-1.6	0.9	-0.5
Blood Eosinophil Count	9.9	76.5	324.0	-15.9	4.8	5.5	8.2	-0.5	5.5	5.1	2.8	18.0	1.8
Blood Platelet Count	0.4	5.2	9.7	-1.8	0.8	-2.3	3.1	2.3	-2.4	-3.0	-2.7	0.9	-2.2
Blood Red Count	0.8	8.1	22.8	3.6	-0.5	1.5	-4.5	-3.1	1.5	1.9	2.0	-4.8	-1.5
Blood White Count	6.8	50.3	213.2	-12.9	2.7	5.0	6.3	-1.5	5.1	3.8	1.6	14.6	2.5
Heel T-Score	0.2	1.4	2.5	1.0	1.6	0.8	-1.3	1.1	0.9	-1.2	1.4	-0.4	-1.5
BMI	0.4	2.2	5.1	-0.9	1.2	2.0	-1.1	-1.3	1.9	2.3	1.7	0.8	-0.3
Height	0.2	4.2	11.0	2.6	1.1	2.0	-3.3	-2.9	2.0	0.4	1.8	-1.8	0.3
Waist Hip Ratio (WHR)	0.2	0.8	1.4	-1.1	1.0	1.1	-0.1	-0.4	1.0	1.2	0.8	0.7	0.5
Systolic Blood Pressure	0.9	4.5	12.2	0.1	-0.8	-3.0	2.0	3.5	-2.9	-2.8	-1.6	-0.8	0.3
Smoking Status	2.1	5.0	12.1	-1.8	1.1	-2.6	3.1	3.5	-2.6	-1.2	-2.4	1.4	1.2
Allergy or Eczema	0.3	0.9	2.0	1.2	-1.4	0.6	-1.0	0.3	0.6	-1.4	0.3	1.1	-0.5
Cardiovascular Disease	2.2	7.4	13.0	0.8	-1.5	-3.6	1.8	3.5	-3.5	-3.3	-3.1	-2.2	-2.0
Hypothyroidism (self reported)	0.7	1.6	8.6	-1.4	0.2	0.8	0.4	-0.3	0.7	1.5	0.1	1.4	2.9
Respiratory disease	0.1	0.2	0.6	0.1	-0.6	0.4	-0.3	0.6	0.4	-0.8	-0.3	0.5	0.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	10.7	3.3	1.2	0.1	-2.4	-1.0	0.2	-0.2	1.1	-1.8	0.2
Lung FEV1/FVC ratio	1.3	6.6	16.2	-0.3	0.5	4.0	-2.9	-2.1	4.0	0.9	3.9	1.3	1.4
Lung FVC	0.1	0.6	1.3	0.3	-1.1	-0.4	0.5	0.7	-0.4	-1.2	-1.1	1.1	0.6
Neuroticism	1.3	3.1	5.9	-0.1	-0.2	-2.1	1.6	2.3	-2.2	-2.2	-2.4	-1.8	-0.3
Chronotype (morning person)	1.4	3.2	10.3	3.2	0.9	0.8	-2.9	-2.2	0.8	-0.5	0.7	-1.0	-2.1
Hair Pigment	0.0	0.7	2.4	0.8	0.3	-0.8	0.3	-1.1	-0.9	0.2	-1.6	0.3	0.7
Tanning	0.2	1.9	6.7	2.3	-1.1	0.3	-2.0	-0.5	0.3	-0.1	0.8	-2.6	-1.1
Hand grip strength (left)	0.8	2.0	6.7	-1.9	-0.3	-0.8	2.2	1.7	-0.8	-0.4	-0.7	2.6	-0.3
Number of treatments/medications taken	0.8	1.5	6.2	1.0	-1.8	-0.7	0.2	2.5	-0.8	-0.6	-0.4	-1.7	0.3
Average weekly spirits intake	2.1	2.6	8.1	-2.4	0.8	1.6	0.3	-0.9	1.6	2.8	2.0	0.8	1.2
Sensitivity / hurt feelings	0.7	1.1	2.2	-0.3	0.9	-1.1	1.2	1.5	-1.2	-1.2	-1.2	-0.6	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	0.8	0.5	-0.7	0.2	-0.1	-0.7	-0.2	-0.5	-1.0	-0.9
Hearing difficulty/problems: Yes	2.2	3.4	9.4	2.1	-0.3	2.1	-3.1	-0.7	2.3	-0.1	2.9	-1.3	-0.1
Relative age of first facial hair	0.9	1.9	4.9	-0.9	-0.9	-1.3	2.0	2.2	-1.3	-1.5	-1.3	0.4	-0.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.2	1.2	1.3	2.0	-2.0	-0.4	2.0	0.5	1.9	-0.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.8	1.7	1.0	-0.4	-0.7	1.6	-0.4	0.6	0.4	-0.8	-1.3
Ever had hysterectomy (womb removed)	0.1	0.2	0.7	0.5	0.2	-0.1	-0.4	0.2	-0.0	0.8	-0.2	-0.5	0.5
Systolic blood pressure, automated reading	0.5	1.3	6.6	0.2	-0.2	-1.4	0.9	2.6	-1.4	-1.2	-0.4	-0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	2.4	-0.2	-0.1	-0.1	0.4	0.7	-0.1	-1.6	-0.1	0.4	0.4
Angina	0.5	0.7	1.9	0.6	1.4	0.6	-0.8	0.7	0.5	-1.4	0.5	0.3	-0.9
Medication for hormone replacement therapy	0.7	0.7	2.1	0.9	-0.0	0.6	-1.3	1.2	0.5	0.1	0.8	-1.5	0.0
Vitamin and mineral supplements	1.1	1.5	10.9	-0.8	3.3	0.4	0.1	-0.4	0.4	-0.5	0.3	1.6	0.5
Supplements: Zinc	0.7	0.7	1.6	0.5	-1.2	-1.1	0.6	0.3	-1.1	-1.1	-1.0	0.3	-0.7
Medication: Co-codamol	0.6	0.7	2.0	-0.7	-0.1	-0.6	0.6	0.5	-0.7	-0.8	-1.4	0.5	-1.3
Medication: Metformin	2.0	2.8	11.4	3.4	1.5	0.0	-2.5	-0.2	0.1	-0.4	1.3	-2.4	-0.6
Diabetes (father)	1.1	1.4	4.3	1.1	-0.5	0.4	-1.1	-2.1	0.3	2.1	0.5	-1.0	1.1
Diabetes (mother)	1.5	2.0	5.2	1.9	-1.9	0.9	-2.3	-1.0	0.8	0.3	0.7	-2.0	0.2
Severe depression (siblings)	1.2	1.4	3.5	-1.3	-0.7	-1.0	1.5	1.9	-1.0	-1.5	-0.9	0.1	1.0
Pack years adult smoking proportion	0.6	0.9	4.1	0.1	0.8	-0.7	0.2	0.7	-0.7	0.5	-1.6	0.6	-2.0
Impedance of leg (right)	0.2	1.0	2.0	0.3	1.1	1.1	-1.1	-0.8	1.1	0.4	1.4	-1.2	-1.0
Leg fat-free mass (left)	0.1	0.3	1.5	0.2	1.2	0.1	-0.4	-0.2	0.2	-0.1	0.3	0.8	0.6
Trunk fat percentage	0.8	3.1	9.5	-0.9	2.1	2.6	-1.5	0.1	2.5	0.6	3.1	0.4	0.0
Hand grip strength (right)	0.5	1.2	5.3	-1.7	-0.7	-0.2	1.6	0.8	-0.3	-0.3	-0.2	2.3	0.2
Townsend deprivation index at recruitment	0.5	0.7	2.2	-0.3	1.5	-0.4	0.4	1.4	-0.3	0.6	-0.3	0.5	1.4
Current tobacco smoking	1.6	2.6	5.6	-0.9	1.3	-2.2	2.0	2.0	-2.1	-0.3	-2.4	0.7	-0.6
Average weekly fortified wine intake	0.5	0.6	1.6	0.1	1.3	1.1	-0.7	0.9	1.1	-0.6	0.8	-0.3	0.3
Maternal smoking around birth	0.4	0.6	1.4	0.4	0.6	0.9	-1.2	0.4	1.0	-0.9	0.4	0.4	-1.2
Fed-up feelings	0.4	0.7	2.6	0.8	-0.6	-0.4	-0.5	0.3	-0.4	0.5	-0.8	-1.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	0.4	1.0	-0.6	-0.1	0.1	-0.5	0.6	-0.2	-0.9	-1.2
Relative age voice broke	0.5	0.7	2.9	-1.7	-0.2	1.2	0.4	0.2	1.1	0.7	0.1	0.8	-0.8
Taking other prescription medications	0.5	0.7	1.9	1.2	0.4	0.6	-1.1	1.4	0.6	-0.5	0.8	-0.7	0.3
Age when periods started (menarche)	0.3	0.6	1.9	-1.4	1.3	0.8	0.2	-0.5	0.8	0.2	0.8	-0.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.1	-0.4	0.5	-0.1	0.4	1.0	-0.0	0.1	-0.2	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	5.2	1.5	-0.5	1.5	-2.3	-1.0	1.5	-0.1	1.4	-0.6	0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.6	-1.2	-1.1	-0.7	1.3	1.3	-0.6	-1.2	-0.4	0.2	0.3
Qualifications: CSEs or equivalent	0.2	0.3	1.1	-1.0	-0.3	0.2	0.5	-1.1	0.1	-0.3	0.0	-0.1	0.5
Serious illness, injury or assault to yourself	0.6	0.7	4.0	0.2	0.6	0.9	-0.5	-0.4	1.0	2.0	0.4	0.2	0.6
High blood pressure	1.6	4.4	9.1	1.2	-1.1	-3.0	1.2	2.6	-2.9	-2.0	-2.4	-2.1	-1.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	3.0	1.7	-1.5	0.3	-1.3	0.1	0.3	-1.2	0.5	-0.5	0.3
Multivitamins +/- minerals	0.5	0.6	3.7	0.2	-1.9	-0.3	0.2	1.1	-0.3	-0.5	-0.1	-0.9	0.3
Stomach or abdominal pain in last month	0.9	1.2	3.3	-1.8	0.8	0.7	0.8	0.9	0.6	-1.2	0.4	1.5	1.4
Supplements: Glucosamine	1.4	1.9	4.8	0.2	-1.6	-1.6	1.5	1.5	-1.6	-1.2	-2.2	-0.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	4.3	-0.9	-0.3	0.6	-0.0	0.2	0.6	0.7	-0.0	0.5	-2.1
Medication: Atenolol	0.3	0.4	1.7	0.8	0.4	-0.5	-0.4	0.4	-0.4	-1.3	-0.3	-0.2	-0.7
Medication: Levothyroxine sodium	0.9	1.6	7.1	-1.4	0.2	-0.8	1.7	0.2	-0.8	0.8	-0.6	1.3	2.7
Sitting height	0.2	1.7	5.1	2.3	0.7	-1.8	-0.2	-0.4	-1.8	-0.6	-1.7	-1.1	0.1
Chronic bronchitis/emphysema (father)	1.9	2.2	6.0	-1.1	0.3	-1.9	2.1	2.5	-1.9	-1.0	-1.4	0.2	0.0
High blood pressure (mother)	2.5	3.4	10.4	-2.7	-0.4	-1.4	3.2	1.5	-1.4	-0.0	-2.0	2.5	-0.8
Body mass index (BMI)	0.3	1.4	3.7	-1.0	1.5	1.7	-0.7	0.6	1.7	0.9	1.9	0.7	-0.4
Impedance of leg (left)	0.1	0.6	1.4	-0.1	0.9	0.7	-0.5	-0.7	0.6	1.0	1.2	-1.1	-0.5
Leg predicted mass (left)	0.1	0.3	1.4	0.1	1.2	0.0	-0.2	-0.1	0.1	-0.1	0.2	0.8	0.7
Trunk fat mass	0.7	3.0	8.8	-0.6	2.3	2.5	-1.7	-0.1	2.5	0.5	3.0	0.3	-0.1
Waist circumference	0.7	2.7	6.9	-0.3	2.4	2.3	-1.7	-0.2	2.2	0.4	2.6	0.6	-0.4
Number of incorrect matches in round	0.6	0.9	3.6	-0.9	-0.0	-0.5	1.0	0.6	-0.5	-1.4	-0.6	1.9	-0.7
Past tobacco smoking	1.0	1.8	5.2	0.6	0.1	1.6	-1.7	-2.3	1.6	2.0	0.8	-0.2	-0.4
Alcohol usually taken with meals	0.1	0.1	0.4	-0.2	-0.7	-0.3	0.5	0.1	-0.3	0.1	-0.5	-0.5	-0.3
Nervous feelings	1.0	1.9	3.8	1.3	0.5	-1.9	0.6	0.7	-1.9	-1.7	-2.0	-1.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	8.3	0.4	0.3	-2.9	1.8	2.8	-2.9	-1.8	-2.5	-0.4	-0.6
Hearing difficulty/problems with background noise	1.2	1.9	4.8	1.8	0.8	-0.7	-0.4	2.2	-0.6	-2.2	-0.7	-0.3	-1.9
Hair/balding pattern: Pattern 2	0.5	0.7	3.5	0.1	-1.9	-0.6	0.4	-0.1	-0.5	1.2	-0.9	-0.1	-0.4
Had menopause	1.0	1.2	5.7	1.3	1.2	0.2	-0.9	-0.8	0.2	0.8	0.9	-0.4	-2.4
Had other major operations	0.3	0.3	1.5	-0.3	-0.3	-0.4	0.6	1.2	-0.4	0.5	-0.5	0.2	-0.6
Forced vital capacity (FVC)	0.1	0.3	0.8	0.2	-0.1	0.6	-0.4	-0.6	0.6	0.0	0.4	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	5.3	2.3	-0.4	0.4	-2.1	-0.5	0.5	-0.5	0.8	-1.2	-0.2
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	5.1	0.7	0.3	-0.8	0.0	2.3	-0.7	-1.2	-0.9	-1.4	1.5
Qualifications: None of the above	0.8	1.6	6.5	0.3	2.5	-1.2	1.1	1.3	-1.1	-0.1	-1.1	0.9	-1.5
Financial difficulties in last 2 years	1.7	2.3	7.7	-1.6	1.0	1.6	0.2	-1.6	1.7	1.4	1.2	2.8	0.7
Mouth/teeth dental problems	0.5	0.7	2.2	1.2	0.5	-0.1	-0.6	-1.4	-0.1	0.1	0.6	-0.8	-1.5
Heart attack	1.4	1.8	8.9	1.1	3.0	-0.2	-0.4	0.7	-0.2	-2.0	-0.5	0.7	-1.6
Allergy	0.4	1.0	3.6	-1.7	1.0	-0.0	1.2	-0.5	-0.0	1.9	-0.1	0.6	0.1
Pain all over the body in last month	1.1	1.2	3.3	1.2	0.7	0.6	-1.2	-1.8	0.6	1.3	-0.2	-1.4	-0.9
Diabetes (self-reported)	1.3	2.0	5.5	2.4	0.5	0.9	-2.3	-1.0	1.0	0.2	1.6	-1.9	0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.0	1.7	-1.3	-0.2	-1.1	0.1	-0.2	-1.3	-0.2	-0.5	-0.7
Medication: Ramipril	0.5	0.6	1.5	1.0	0.1	0.3	-0.9	-0.3	0.3	0.9	1.0	-1.2	-0.8
Medication: Simvastatin	1.4	2.1	8.2	2.5	1.3	-1.0	-1.3	0.4	-0.8	-0.9	0.5	-2.9	-0.7
Fluid intelligence score	0.2	0.4	2.1	0.2	-0.4	0.2	-0.1	-1.0	0.3	-1.4	0.2	-0.6	0.4
Illnesses of siblings	1.2	1.6	4.7	-1.1	1.9	1.0	0.4	-2.1	0.8	0.2	0.9	2.2	0.0
Neuroticism score	3.1	6.4	15.1	0.7	-0.5	-3.7	2.1	2.5	-3.7	-2.3	-3.9	-2.3	0.0
Weight	0.3	1.5	4.5	-0.1	2.1	1.5	-1.2	-0.2	1.5	0.6	1.9	0.6	-0.2
Impedance of arm (right)	0.1	0.7	1.6	-0.0	0.3	0.9	-0.6	-1.0	0.9	-1.3	1.1	-0.6	0.6
Arm fat percentage (right)	0.6	2.5	8.2	-0.7	1.9	2.3	-1.4	0.5	2.3	0.0	2.9	0.1	0.2
Trunk fat-free mass	0.1	0.5	3.0	0.8	1.7	-0.0	-0.6	-0.8	0.0	0.5	0.2	0.5	-0.3
Hip circumference	0.5	2.0	5.2	-0.9	1.9	2.0	-1.0	-0.4	2.0	0.1	2.3	1.1	-0.3
Time employed in main current job	0.3	0.4	1.0	0.5	0.5	-1.0	0.2	0.2	-1.0	-0.1	-0.7	-0.7	0.5
Alcohol intake versus 10 years previously	0.6	0.9	2.7	0.8	-1.4	1.0	-1.6	0.1	0.9	0.9	0.8	-0.3	-0.3
Father’s age at death	0.6	0.8	2.5	-1.0	-1.6	-0.8	1.1	0.7	-0.9	-0.6	-0.5	-0.6	0.2
Worrier / anxious feelings	2.0	3.8	8.0	-0.2	0.7	-2.8	2.2	2.3	-2.8	-2.1	-2.5	-0.4	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.0	-0.7	1.7	-0.4	1.0	0.5	-0.4	0.7	-0.7	0.3	0.2
Falls in the last year	0.6	0.8	3.2	-1.8	0.5	1.2	0.4	0.7	1.2	-0.9	0.1	0.1	-0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	-0.2	-0.5	-0.3	0.5	0.4	-0.3	0.5	-0.3	0.9	0.8
Number of live births	1.6	2.3	5.1	0.2	-0.1	-1.9	1.4	2.3	-1.8	-1.9	-1.7	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.7	0.1	-0.7	1.6	-1.1	-1.1	1.6	0.1	1.5	0.9	1.0
Pulse rate	0.1	0.2	1.1	0.2	0.8	0.1	-0.3	1.1	0.2	0.5	0.2	-0.3	-0.1
Happiness	1.3	1.5	3.3	-0.6	-0.4	-1.3	1.6	1.4	-1.2	-1.1	-1.6	0.2	1.8
Noisy workplace	0.3	0.3	2.5	0.1	-0.7	-0.1	-0.1	-0.1	-0.1	0.2	-0.3	0.1	-1.6
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	-0.6	-0.2	1.0	-0.5	1.1	0.9	0.3	0.5	1.0	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	0.9	0.8	-1.1	0.2	0.1	-1.2	0.3	-0.5	-0.7	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	4.1	-1.0	-1.2	-0.5	0.9	2.0	-0.5	-0.3	-1.1	1.3	1.3
Asthma	0.2	0.4	0.9	0.9	-0.9	-0.5	-0.1	0.3	-0.4	-0.8	-0.7	-0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	7.3	0.1	-0.3	-1.2	0.7	2.7	-1.2	-0.2	-0.7	0.4	0.9
Medication: Cholesterol lowering	0.8	1.2	3.3	1.5	0.6	-0.2	-0.9	-0.5	-0.2	-1.8	0.0	-1.8	-1.3
Depression (self-reported)	0.2	0.2	0.6	-0.3	-0.7	0.1	-0.0	0.1	0.0	-0.6	-0.4	0.6	-0.4
Medication: Lansoprazole	0.1	0.1	0.6	-0.3	0.5	-0.1	0.2	0.4	-0.2	0.8	0.1	-0.0	0.4
Prospective memory result	1.2	1.4	4.7	1.7	0.4	-0.3	-1.0	-2.2	-0.5	0.7	0.5	-1.3	1.7
Lung cancer (father)	0.2	0.3	0.7	-0.8	0.8	0.5	0.0	-0.1	0.6	-0.0	0.1	0.1	-0.8
Illnesses of mother	0.7	0.8	2.7	0.2	-0.4	-1.6	1.1	-0.3	-1.6	-0.7	-0.8	-0.0	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.9	-0.5	0.2	1.7	-0.8	-1.1	1.6	0.3	1.5	1.1	1.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.2	-0.4	0.4	-0.3	-0.2	0.5	0.4	0.7	-0.5	-0.5
Impedance of arm (left)	0.2	0.7	1.6	-0.5	0.3	1.1	-0.4	-1.0	1.0	-1.2	1.2	-0.2	0.6
Arm fat mass (right)	0.5	2.2	6.5	-0.8	2.2	2.0	-1.2	0.2	2.0	0.7	2.6	0.5	0.1
Trunk predicted mass	0.1	0.6	3.2	0.8	1.8	0.1	-0.6	-0.8	0.1	0.6	0.3	0.5	-0.3
Standing height	0.1	1.0	3.8	1.5	1.9	0.0	-1.1	-1.7	-0.0	-0.0	0.3	-0.1	0.3
Length of working week for main job	0.7	0.8	2.6	0.4	0.9	0.9	-1.0	-0.8	0.9	1.6	0.6	0.0	-0.6
Exposure to tobacco smoke at home	0.6	0.7	3.2	0.3	0.6	-0.7	-0.0	-1.1	-0.7	0.7	-0.5	-1.8	0.4
Breastfed as a baby	0.2	0.2	1.0	0.4	0.7	0.0	-0.1	-0.0	-0.1	-0.3	1.0	0.3	0.4
Tense / ‘highly strung’	3.4	5.6	11.8	1.6	-1.6	-2.7	0.5	2.8	-2.8	-3.2	-3.4	-1.9	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	12.0	0.7	-1.5	-2.2	1.0	3.0	-2.2	-3.5	-2.6	-1.2	-0.6
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	-0.2	-0.6	-0.2	-0.1	1.1	-0.2	-0.8	-0.2	-0.9	0.2
Birth weight of first child	0.6	1.1	3.0	-1.5	0.6	-0.8	1.7	0.3	-0.9	-0.1	-1.2	1.2	1.0
Peak expiratory flow (PEF)	1.0	2.2	5.1	-1.0	-1.5	2.3	-0.9	-0.3	2.2	0.2	2.0	1.3	1.6
Pulse wave reflection index	0.4	0.4	2.4	-0.0	-1.6	-0.1	-0.0	-0.4	-0.1	-0.1	-0.5	-0.5	-1.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	6.6	0.3	-0.6	-0.7	0.3	-0.2	-0.7	-0.7	-0.6	-1.3	2.6
Loud music exposure frequency	2.2	2.4	5.1	-0.9	-0.6	-2.3	1.8	1.5	-2.2	1.8	-1.4	-1.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	3.1	-0.2	-1.7	0.4	-0.3	-0.2	0.4	0.8	-0.6	-0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.9	-0.6	0.2	1.4	-0.5	-0.6	1.3	0.5	0.5	-0.5	0.4
Blood clot in the leg (DVT)	1.6	2.1	7.1	1.8	-0.6	1.4	-2.7	-1.1	1.4	-1.1	1.0	-1.4	-1.1
Medication: Paracetamol	1.7	2.8	11.3	-1.3	0.7	-1.5	2.3	3.4	-1.5	-1.1	-1.4	1.0	1.0
Headache pain in last month	0.7	1.2	8.1	-1.3	-0.6	0.5	0.7	0.3	0.5	0.2	0.2	0.4	2.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	-1.8	1.0	0.5	0.9	-0.2	0.4	1.7	0.2	1.9	0.9
Glaucoma (self-reported)	0.9	1.0	6.6	2.6	0.9	-0.1	-1.4	0.1	-0.1	-0.0	0.1	-0.8	-0.2
Gout (self-reported)	1.5	2.1	7.8	0.7	0.8	1.5	-1.6	-1.8	1.5	1.5	2.8	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	6.4	-1.0	-0.3	-0.1	0.9	0.0	-0.2	0.8	-0.7	0.9	2.5
Medication: Amlodipine	1.9	2.6	6.1	2.5	-0.5	-2.2	-0.2	0.5	-2.2	-1.3	-1.6	-1.6	-1.7
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.8	-0.6	-0.2	1.3	-0.7	0.2	1.3	-0.5	0.8	1.0	1.0
Birth weight	0.3	0.7	2.7	-1.4	-0.1	-0.9	1.6	0.5	-1.0	-0.1	-0.6	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.4	0.6	0.5	0.2	-0.6	1.2	0.2	-0.9	-0.7	-0.9	0.2
High blood pressure (siblings)	1.3	1.9	5.0	1.1	-2.2	-1.4	0.2	1.9	-1.3	-0.9	-1.0	-1.5	-0.9
Forced vital capacity (FVC), Best measure	0.1	0.5	1.8	-0.2	0.7	0.6	-0.1	-0.8	0.5	0.4	0.3	0.9	1.3
Body fat percentage	0.8	3.1	10.0	-0.8	1.9	2.6	-1.6	0.2	2.5	0.6	3.2	0.2	-0.2
Leg fat percentage (right)	0.9	3.1	9.1	-0.2	2.3	2.4	-1.9	0.5	2.4	0.6	3.0	-0.5	-0.8
Arm fat-free mass (right)	0.1	0.4	2.4	0.4	1.5	-0.2	-0.3	-0.4	-0.2	1.0	0.1	0.6	-0.4
Exposure to tobacco smoke outside home	1.1	1.4	4.1	2.0	-0.6	-0.6	-0.9	0.4	-0.8	-0.8	-0.3	-1.8	-2.0
Comparative body size at age 10	0.7	1.9	5.2	-0.0	-0.8	-1.8	1.7	0.5	-1.7	0.2	-2.3	1.5	-1.1
Number of full brothers	0.5	0.7	1.8	0.7	-1.3	0.1	-0.4	0.3	0.1	-1.3	-0.2	-1.1	1.1
Worry too long after embarrassment	2.0	3.4	6.3	1.3	-1.1	-2.5	0.9	1.9	-2.5	-1.9	-2.3	-1.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	11.2	0.8	-0.1	-2.1	1.1	3.3	-2.1	-2.5	-2.2	-0.2	-0.9
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	-1.4	-0.0	-0.4	1.5	1.0	-0.4	0.1	-1.0	1.6	-0.2
Number of children fathered	0.4	0.5	1.8	-0.1	0.3	0.8	-0.4	0.0	0.8	-1.3	0.5	0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	3.9	-2.0	1.5	0.1	1.3	1.9	0.0	-1.5	0.2	1.1	1.1
Age at first live birth	0.4	0.8	4.9	-0.4	-0.9	0.2	0.2	-0.9	0.1	-0.6	0.4	0.7	2.2
Pulse wave peak to peak time	0.2	0.2	0.5	0.2	0.7	-0.4	0.2	0.1	-0.4	-0.5	-0.6	0.6	0.7
Health satisfaction	0.2	0.3	0.6	0.6	0.6	0.4	-0.8	0.8	0.4	-0.7	0.4	0.0	0.4
Shortness of breath walking on level ground	0.6	0.7	2.6	-0.7	0.9	-0.5	0.9	0.6	-0.6	0.4	-0.9	0.5	1.6
Qualifications: College or University degree	0.4	1.3	5.8	2.4	-0.6	-0.6	-1.3	-0.2	-0.6	-1.4	-0.8	-1.5	0.2
Eye problems/disorders: None of the above	1.9	2.2	4.9	-1.8	-0.8	-1.3	2.2	1.3	-1.2	0.4	-2.1	1.7	0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.7	-0.1	-0.8	0.0	0.1	0.5	0.1	-0.2	-0.6	-0.2	0.0
Emphysema/chronic bronchitis	0.3	0.4	1.2	-0.1	0.1	0.6	-0.6	-0.3	0.5	-0.7	0.7	-0.5	1.1
Medication for pain relief, constipation, heartburn	0.9	1.5	9.9	-0.4	-0.5	1.1	-0.8	-3.1	1.0	0.4	0.8	0.2	-1.0
Neck or shoulder pain in last month	2.5	3.6	12.9	-0.0	1.3	-2.0	1.6	3.6	-2.0	-2.2	-1.3	-0.4	2.1
Medication: Blood pressure	0.8	1.5	3.2	1.5	-1.8	-1.1	-0.2	0.5	-1.0	-1.5	-1.2	-1.6	-0.8
Angina (self-reported)	0.5	0.7	2.4	1.0	1.0	0.4	-1.1	0.6	0.4	-1.5	0.3	-0.5	-0.7
Migraine (self-reported)	1.0	1.2	3.9	1.2	-0.8	-0.5	-0.3	-1.5	-0.5	2.0	-0.1	-1.8	0.1
Medication: Ibuprofen	0.6	0.7	4.0	-0.2	-0.4	-0.6	0.5	2.0	-0.6	0.2	-0.1	0.1	1.2
Medication: Allopurinol	1.8	2.4	6.9	0.2	1.1	2.0	-1.6	-1.8	2.0	1.4	2.6	0.1	0.4
Medication: Omeprazole	0.3	0.4	0.9	-0.0	0.1	1.0	-0.7	-0.5	0.9	-0.4	0.6	0.0	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.6	0.2	0.6	0.1	-0.3	0.6	-0.1	0.4	0.7	0.5
Mean time to correctly identify matches	0.6	1.1	2.7	-1.6	1.4	-0.5	1.6	-0.7	-0.6	0.3	-0.9	1.2	-0.4
Heart disease (mother)	1.5	1.9	10.6	-0.5	0.2	1.3	-0.8	-1.3	1.3	1.2	0.7	-0.4	-3.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	11.7	-2.6	-0.5	1.2	1.5	1.9	1.3	-0.4	0.1	3.4	1.1
Whole body fat mass	0.7	2.8	8.3	-0.5	2.2	2.4	-1.6	0.1	2.3	0.7	2.9	0.4	-0.2
Leg fat mass (right)	0.7	2.6	7.0	-0.5	2.4	2.2	-1.6	0.3	2.2	0.8	2.6	0.1	-0.7
Arm predicted mass (right)	0.1	0.6	3.2	0.5	1.8	0.1	-0.5	-0.4	0.1	1.0	0.3	0.7	-0.5
Pulse rate, automated reading	0.2	0.5	1.6	-0.1	1.3	-0.4	0.4	0.9	-0.4	1.0	-0.9	0.4	0.7
Alcohol intake frequency.	1.3	3.0	11.9	3.4	0.0	0.4	-2.8	-1.5	0.5	-0.2	0.1	-2.7	-0.6
Comparative height size at age 10	0.2	1.1	8.4	0.4	2.9	-0.0	-0.2	0.3	-0.0	-0.8	0.2	0.3	1.2
Number of full sisters	0.4	0.5	2.0	-0.8	-0.2	0.2	0.5	-1.4	0.4	1.0	0.9	0.8	0.1
Suffer from ‘nerves’	2.1	3.2	8.0	0.7	-0.3	-2.8	1.6	1.5	-2.8	-1.5	-2.3	-1.1	1.5
Overall health rating	0.2	0.5	1.2	-0.5	1.1	0.9	-0.0	0.5	1.0	0.3	0.2	0.5	1.1
Chest pain or discomfort	1.2	1.7	4.9	-0.9	-0.5	-0.7	1.4	2.0	-0.7	-0.8	-1.2	1.2	2.2
Had major operations	0.5	0.6	1.9	-1.1	-1.4	0.2	0.8	-0.0	0.3	-0.2	-0.7	0.9	0.7
Age at last live birth	0.4	0.6	3.4	-0.5	-1.2	0.5	-0.1	-0.7	0.6	0.1	0.3	0.2	1.8
Family relationship satisfaction	1.3	1.6	3.4	-1.0	-0.4	-1.5	1.9	1.5	-1.5	-1.4	-1.3	-0.0	1.1
Leg pain on walking	0.3	0.4	1.4	0.3	-0.7	-0.5	0.4	1.2	-0.6	-0.2	-1.1	0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	-0.6	-1.4	0.8	-0.3	-0.6	0.8	1.0	0.6	-0.0	1.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.8	0.7	-0.6	0.5	-0.9	-0.1	0.5	0.7	0.6	-0.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.4	0.0	-2.0	0.3	-0.2	0.1	0.3	-2.1	-0.3	-0.7	-0.8
Medication: Aspirin	1.0	1.3	5.4	2.3	-1.0	0.0	-1.5	0.2	0.0	-0.6	-0.3	-1.9	0.3
Supplements: Vitamin C	2.0	2.4	6.4	1.2	-2.5	-2.0	0.8	0.2	-2.1	-1.1	-2.4	-0.7	0.0
Knee pain experienced in last month	0.3	0.4	1.1	-1.0	1.0	-0.4	1.0	0.6	-0.4	-0.4	0.2	0.3	-0.3
Hypertension (Self-reported)	1.7	4.8	9.5	1.4	-1.0	-3.1	1.1	2.9	-3.0	-2.2	-2.5	-1.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	-0.8	-0.3	-0.6	1.0	0.6	-0.6	0.1	-0.7	-0.1	0.8
Illnesses of father: Heart disease	1.2	1.7	4.9	2.2	-1.4	0.3	-2.1	-0.6	0.3	0.4	0.4	-1.9	-0.8
Illnesses of siblings: Diabetes	1.0	1.2	5.6	1.4	0.2	-0.6	-1.0	1.0	-0.4	1.2	0.2	-2.4	-0.5
Smoking status: Previous	0.5	0.8	2.6	0.4	0.4	-1.1	0.7	1.6	-1.1	-1.4	0.1	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	0.4	0.7	-1.1	0.3	-0.2	-1.2	0.4	-1.0	-0.3	0.5
Whole body fat-free mass	0.1	0.4	2.4	0.5	1.5	-0.1	-0.3	-0.5	-0.1	0.4	0.2	0.7	0.1
Leg fat-free mass (right)	0.1	0.3	0.8	0.1	0.9	-0.4	0.1	-0.0	-0.4	0.1	-0.1	0.9	0.8
Arm fat percentage (left)	0.7	2.6	8.5	-1.0	1.9	2.4	-1.3	0.5	2.3	0.2	2.9	0.3	0.0
Average weekly red wine intake	0.3	0.5	2.2	0.5	0.9	0.1	0.1	-0.4	0.1	-1.5	0.0	0.0	-1.0
Handedness (chirality/laterality): Left-handed	2.4	2.9	7.2	1.3	-1.5	-2.5	0.5	1.1	-2.7	-1.8	-1.7	-1.4	-1.4
Mood swings	1.5	2.7	7.4	0.2	-0.3	-2.3	1.3	1.9	-2.3	-0.9	-1.7	-2.7	-0.2
Loneliness, isolation	1.8	2.5	6.8	1.5	1.3	-1.8	0.1	2.6	-1.7	-1.4	-1.6	-0.9	-1.8
Long-standing illness, disability or infirmity	0.7	1.1	3.3	1.8	-0.8	0.5	-1.6	1.1	0.5	-1.0	-0.1	-1.5	0.1
Ever had bowel cancer screening	1.2	1.3	6.6	0.9	1.3	-1.4	0.5	2.6	-1.3	-0.5	-0.5	0.2	-0.1
Diabetes diagnosed by doctor	1.7	2.8	9.0	3.0	0.9	0.7	-2.7	-0.6	0.8	-0.0	1.8	-2.4	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	4.7	0.1	-0.1	-0.8	0.8	1.5	-0.9	-2.2	-1.5	0.3	-0.3
Friendships satisfaction	0.3	0.4	1.0	-0.7	-0.4	0.5	0.2	0.3	0.5	-0.8	0.9	-0.3	1.0
Qualifications: nursing, teaching	0.4	0.6	1.9	1.2	-0.0	0.1	-0.9	-0.1	0.1	0.6	0.7	-0.9	-1.4
Commuting to job workplace: Walk	0.7	0.8	2.9	0.0	1.1	0.7	-0.2	-0.8	0.7	-1.7	0.3	0.5	-1.3
Eye problems/disorders: Cataract	1.4	1.6	3.8	0.8	-0.5	1.9	-2.0	-0.9	1.8	0.4	1.6	-0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.7	1.0	0.1	0.6	-1.2	-1.3	0.6	0.9	0.5	-0.6	0.8
Medication for cholesterol	0.8	1.2	5.7	-1.3	0.5	-0.1	1.3	-0.7	-0.1	-0.9	-1.0	2.4	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.8	15.8	0.3	1.1	-2.8	1.9	4.0	-2.8	-2.0	-2.6	0.8	-0.6
Back pain experienced in last month	0.6	0.8	2.0	0.8	-0.9	-0.4	-0.6	1.2	-0.5	-1.4	-0.8	-1.2	0.7
Mineral and other dietary supplements	2.1	2.8	12.5	0.2	3.5	1.6	-1.6	-1.7	1.7	0.3	1.9	0.7	-0.2
Breast cancer (self-reported)	1.1	1.3	4.5	2.1	-0.5	0.6	-1.7	-1.5	0.5	1.4	0.5	-0.3	0.3
Asthma (self-reported)	0.3	0.6	1.1	0.7	-1.0	-0.7	0.2	0.7	-0.7	-1.0	-1.0	-0.5	0.7
Osteoporosis (self-reported)	1.0	1.2	4.0	-0.4	-1.9	-0.9	1.2	0.6	-0.9	-0.6	-2.0	0.7	0.1
Osteoarthritis (self-reported)	0.7	0.9	3.0	1.7	1.0	-0.6	-0.7	1.3	-0.7	-1.0	-0.0	-0.9	-0.5
Medication: Aspirin	0.9	1.1	4.7	2.2	-0.6	-0.0	-1.4	0.3	-0.0	-0.8	-0.1	-1.9	-0.1
Medication: Gliclazide	4.1	4.6	13.0	2.9	0.7	1.9	-3.6	-2.3	1.9	0.1	2.9	-1.7	-0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	-0.6	0.7	-0.5	0.8	1.2	-0.5	-1.0	-0.5	1.1	0.3
Smoking status: Current	1.8	2.9	6.7	-1.3	1.1	-2.1	2.2	2.1	-2.1	-0.5	-2.6	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	9.9	-1.3	-0.2	3.1	-1.0	-1.3	3.1	-1.1	1.3	2.1	1.9
Whole body water mass	0.1	0.3	2.1	0.4	1.5	-0.1	-0.3	-0.5	-0.1	0.4	0.2	0.8	0.2
Leg predicted mass (right)	0.1	0.3	0.9	0.1	0.9	-0.4	0.2	0.0	-0.4	0.1	-0.2	0.9	0.9
Arm fat mass (left)	0.5	2.1	6.5	-0.6	2.1	2.0	-1.2	0.2	1.9	0.7	2.6	0.4	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.6	1.1	-0.2	-0.6	-0.2	1.5	-0.5	-0.1	-0.3	-1.6	-1.0
Average weekly champagne plus white wine intake	0.6	0.8	2.1	0.3	-1.3	-1.0	0.7	0.7	-1.0	-1.2	-1.4	0.1	0.4
Miserableness	0.4	0.7	2.0	-0.2	-0.1	-0.7	0.6	1.4	-0.6	-0.0	-1.0	-1.3	1.1
Guilty feelings	2.4	3.6	7.2	1.5	-1.1	-2.1	0.4	1.6	-2.2	-2.7	-2.5	-2.3	-1.3
Wears glasses or contact lenses	1.5	1.7	3.9	1.0	-0.0	1.9	-2.0	-0.4	1.9	-0.6	1.2	-0.7	-1.6
Ever taken oral contraceptive pill	0.8	0.9	2.6	0.3	-0.1	-0.9	0.8	0.1	-1.0	-1.6	-0.9	0.5	-1.6
Hearing aid user	0.9	1.0	2.4	0.1	-1.1	1.5	-1.1	-0.8	1.5	0.2	1.6	0.3	-0.2
Mother’s age at death	0.6	0.7	2.9	-0.7	-0.1	1.0	-0.2	-0.1	1.0	-0.8	1.1	-0.1	-1.7
Financial situation satisfaction	0.9	1.2	3.9	-2.0	0.2	-0.7	1.8	0.9	-0.6	-0.1	-0.3	0.8	1.4
Tinnitus: Yes, now most or all of the time	1.4	1.6	5.1	2.2	1.1	-0.9	-0.8	0.5	-1.0	-1.2	-0.7	-0.6	-2.3
Commuting to job workplace: Public transport	0.7	0.8	2.2	0.1	-1.3	0.5	-0.4	0.4	0.5	-1.5	-0.2	-1.3	1.2
Eye problems/disorders: Glaucoma	1.3	1.6	8.0	2.8	0.8	0.1	-2.1	-0.5	0.2	0.2	0.6	-1.5	0.3
Medication: Blood pressure	0.2	0.4	2.0	-0.1	0.5	-0.8	0.5	1.4	-0.7	0.1	0.0	-0.7	-0.1
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.7	0.4	-0.2	-0.9	0.4	1.4	-0.9	-1.9	-1.5	0.2	1.0
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.6	-0.2	-2.1	-1.6	1.4	2.0	-1.7	-1.1	-2.0	-0.4	-0.2
High cholesterol (Self-reported)	0.7	1.2	2.0	1.4	-1.2	-1.2	-0.2	1.0	-1.1	-1.1	-0.6	-1.4	-1.3
Medication: Bendroflumethiazide	1.2	1.8	4.6	-0.0	-0.3	-1.8	1.1	2.1	-1.7	0.0	-1.3	-0.9	1.8
Medication: Paracetamol	0.6	0.9	5.2	-1.2	0.9	0.3	1.0	2.3	0.3	-0.4	-0.1	0.7	0.3
Medication: Lisinopril	1.1	1.4	5.6	1.0	-0.3	-1.4	0.2	2.4	-1.3	-0.5	-1.3	-1.3	0.1
Medication: Atorvastatin	0.8	1.0	3.4	-1.0	-1.2	1.8	-0.5	0.2	1.8	-0.2	0.7	0.2	-0.6
Illnesses of father: High blood pressure	0.9	1.1	3.5	-1.2	-0.4	-1.0	1.5	1.9	-1.0	-1.2	-0.6	0.5	-0.2
Alcohol drinker status: Never	1.0	1.2	3.9	2.0	-1.4	-0.4	-1.2	-0.1	-0.4	-1.1	-1.2	-0.9	-0.7
Ever smoked	1.2	2.0	5.7	-0.9	0.5	-1.7	2.1	2.4	-1.7	-1.2	-1.2	0.9	-0.1
Basal metabolic rate	0.1	0.5	3.0	0.4	1.7	0.3	-0.6	-0.5	0.3	0.5	0.7	0.6	0.1
Leg fat percentage (left)	0.8	2.7	8.6	-0.5	2.2	2.2	-1.5	0.5	2.2	1.0	2.9	-0.2	-0.5
Arm fat-free mass (left)	0.1	0.5	3.1	0.5	1.8	-0.2	-0.4	-0.1	-0.2	0.9	0.3	0.5	-0.1
Number of operations (self-reported)	0.1	0.1	0.4	0.3	-0.6	-0.3	0.1	0.7	-0.2	0.0	0.0	0.1	0.1
Average weekly beer plus cider intake	1.6	2.3	6.7	-2.0	1.2	-1.3	2.0	0.0	-1.3	1.0	-1.1	1.1	2.6
Irritability	2.1	3.5	18.7	2.6	-0.3	-1.6	-1.1	0.6	-1.6	-0.8	-1.5	-4.3	-0.0
Risk taking	0.7	1.1	2.4	-0.3	-0.2	-1.5	1.1	0.2	-1.5	-0.9	-1.5	-0.6	-1.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	2.2	0.4	0.6	0.0	-0.3	1.5	0.1	-0.5	0.0	-0.2	0.1
Fractured/broken bones in last 5 years	1.8	2.3	8.9	-1.8	-0.6	1.3	0.0	-2.5	1.2	3.0	0.0	0.3	0.9
Age started oral contraceptive pill	0.3	0.3	0.7	0.6	-0.9	0.2	-0.4	-0.6	0.2	0.9	0.7	0.1	-0.7
Diastolic blood pressure, automated reading	0.2	0.7	2.4	-1.1	0.6	0.5	0.1	0.9	0.5	1.0	1.6	-0.0	0.6
Ever depressed for a whole week	1.4	1.8	8.8	-0.3	0.4	-1.3	1.2	3.0	-1.3	-0.6	-1.3	0.6	1.1
Unable to work because of sickness or disability	1.5	1.9	6.2	0.4	2.3	-1.3	1.1	0.5	-1.3	-0.3	-1.5	-0.2	-2.5
Commuting to job workplace: Cycle	0.5	0.6	2.0	-0.5	1.2	0.3	0.4	-0.5	0.2	-1.1	-0.0	0.9	1.4
Myopia	0.4	0.5	1.4	0.8	-1.2	0.4	-0.3	-0.6	0.5	1.1	-0.8	0.1	-0.6
Vascular/heart problems diagnosed by doctor	1.8	5.0	9.1	-1.8	0.6	3.0	-0.7	-2.8	2.9	2.7	2.3	2.4	1.4
Cholesterol lowering medication	0.9	1.3	3.9	2.0	-0.4	0.3	-1.6	0.3	0.4	1.1	0.8	-1.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-0.7	0.7	1.1	-0.2	0.2	1.1	-0.2	0.8	0.6	-0.2
Pain experienced in last month	0.4	0.7	2.4	0.3	0.3	-0.9	0.5	-0.6	-0.9	0.9	-1.1	0.6	-1.6
Supplements: Calcium	0.8	0.9	2.8	0.4	-1.6	-0.8	0.6	0.5	-0.9	-0.7	-1.7	0.8	-0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	0.4	0.5	-0.2	-0.4	-0.3	-0.1	-0.5	0.9	-0.6	-0.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	9.1	0.9	3.0	0.1	-0.5	0.3	0.0	-1.6	-0.2	1.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	9.5	2.1	-0.9	1.6	-3.1	-1.3	1.6	-1.2	0.9	-1.8	-1.2
Heart disease (siblings)	0.7	0.9	2.1	-1.4	-0.8	1.4	0.1	0.5	1.4	-0.2	0.6	1.2	-0.4
Alcohol drinker status: Previous	1.9	2.1	4.7	1.9	-0.1	1.0	-2.0	-2.1	1.0	0.2	0.5	-2.2	1.5
Pack years of smoking	0.6	0.9	4.7	0.5	0.7	-0.5	-0.2	0.9	-0.5	0.4	-1.5	0.3	-2.2
Impedance of whole body	0.1	0.5	1.5	-0.2	0.1	1.0	-0.6	-0.7	0.9	-0.1	1.2	-0.7	0.3
Leg fat mass (left)	0.6	2.5	6.8	-0.6	2.3	2.1	-1.4	0.1	2.1	1.3	2.6	0.2	-0.3
Arm predicted mass (left)	0.1	0.5	2.8	0.5	1.7	-0.2	-0.3	-0.1	-0.2	0.9	0.3	0.6	-0.2