Best TWAS P=2.1e-16 · Best GWAS P=2.77e-82 conditioned to 6.91e-56
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | AK9 | 0.16 | 0.14 | enet | 32 | 0.14 | 3.7e-08 | 4.7 | 5.3 | 1.5e-07 | -0.12 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Coronary | RP11-425D10.10 | 0.31 | 0.00 | enet | 20 | 0.01 | 1.3e-01 | 7.3 | -8.2 | 2.1e-16 | 0.15 | 0.04 | 0.05 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | ARMC2 | 0.57 | 0.30 | enet | 22 | 0.32 | 7.0e-09 | 1.5 | 6.4 | 1.3e-10 | -0.37 | 0.84 | 0.11 | TRUE |
| 4 | GTEx | Lung | ARMC2 | 0.12 | 0.01 | lasso | 5 | 0.03 | 1.6e-03 | 1.6 | 5.2 | 1.6e-07 | -0.35 | 0.06 | 0.16 | FALSE |
| 5 | GTEx | Pancreas | FOXO3 | 0.12 | 0.00 | enet | 17 | 0.05 | 3.0e-03 | -0.4 | -5.7 | 1.6e-08 | 0.01 | 0.07 | 0.04 | TRUE |
| 6 | GTEx | Spleen | RP11-425D10.10 | 0.17 | 0.04 | enet | 26 | 0.12 | 4.7e-04 | -3.0 | -5.2 | 2.5e-07 | 0.13 | 0.27 | 0.06 | FALSE |
| 7 | METSIM | Adipose | SMPD2 | 0.06 | 0.08 | enet | 14 | 0.08 | 2.0e-12 | -3.1 | -6.6 | 3.2e-11 | 0.31 | 1.00 | 0.00 | TRUE |
| 8 | NTR | Blood | SESN1 | 0.03 | 0.04 | lasso | 3 | 0.03 | 5.4e-11 | 6.3 | 6.3 | 2.6e-10 | -0.01 | 1.00 | 0.00 | FALSE |
| 9 | YFS | Blood | CD164 | 0.03 | 0.01 | blup | 382 | 0.02 | 1.9e-07 | 2.0 | -5.4 | 7.2e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | FOXO3 | 0.03 | 0.01 | lasso | 3 | 0.02 | 3.2e-07 | -7.6 | 7.2 | 4.6e-13 | -0.08 | 1.00 | 0.00 | TRUE |
| 11 | YFS | Blood | SESN1 | 0.10 | 0.12 | lasso | 15 | 0.12 | 1.4e-36 | 6.4 | 6.3 | 3.8e-10 | -0.02 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ARMC2 | 0.04 | 0.05 | lasso | 1 | 0.04 | 3.4e-04 | 7.3 | -7.3 | 3.4e-13 | 0.04 | 0.22 | 0.02 | TRUE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SESN1 | 0.02 | 0.04 | lasso | 4 | 0.04 | 1.1e-04 | 6.3 | 6.3 | 2.4e-10 | -0.01 | 0.52 | 0.01 | FALSE |