Best TWAS P=1.09e-10 · Best GWAS P=8.25e-16 conditioned to 2.54e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FRK | 0.06 | 0.06 | lasso | 2 | 0.05 | 6.1e-07 | 5.8 | 5.9 | 3.8e-09 | -0.05 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | DCBLD1 | 0.20 | 0.13 | lasso | 7 | 0.15 | 2.0e-12 | 6.4 | -6.5 | 1.1e-10 | 0.02 | 0.09 | 0.91 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | DCBLD1 | 0.13 | 0.09 | enet | 10 | 0.07 | 1.8e-04 | -5.8 | -6.1 | 8.1e-10 | 0.06 | 0.09 | 0.84 | FALSE |
| 4 | GTEx | Adrenal Gland | ZUFSP | 0.24 | 0.03 | enet | 25 | 0.10 | 2.0e-04 | -8.1 | 5.3 | 1.1e-07 | -0.68 | 0.01 | 0.90 | TRUE |
| 5 | GTEx | Breast Mammary Tissue | DCBLD1 | 0.10 | 0.02 | lasso | 4 | 0.03 | 1.1e-02 | 2.1 | -5.2 | 1.8e-07 | 0.07 | 0.11 | 0.36 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | DCBLD1 | 0.06 | -0.01 | lasso | 1 | 0.00 | 3.9e-01 | 6.4 | -6.4 | 1.4e-10 | 0.00 | 0.04 | 0.11 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Female) | RP3-486I3.4 | 0.11 | 0.00 | lasso | 3 | 0.00 | 4.3e-01 | -5.6 | 5.6 | 2.0e-08 | -0.02 | 0.02 | 0.44 | FALSE |
| 8 | GTEx | Cells EBV-transformed lymphocytes | FRK | 0.12 | 0.07 | enet | 12 | 0.09 | 8.1e-04 | -5.7 | -5.4 | 5.5e-08 | 0.03 | 0.05 | 0.86 | FALSE |
| 9 | GTEx | Lung | DCBLD1 | 0.21 | 0.10 | enet | 21 | 0.09 | 1.5e-07 | -5.8 | -5.6 | 2.7e-08 | 0.06 | 0.62 | 0.37 | FALSE |
| 10 | GTEx | Muscle Skeletal | RP11-351A11.1 | 0.09 | 0.08 | enet | 12 | 0.08 | 3.7e-08 | 6.4 | 5.1 | 2.7e-07 | 0.00 | 0.00 | 1.00 | TRUE |
| 11 | GTEx | Nerve Tibial | RP3-486I3.4 | 0.07 | 0.01 | enet | 15 | 0.01 | 1.0e-01 | -4.5 | 5.2 | 1.9e-07 | 0.04 | 0.10 | 0.59 | FALSE |
| 12 | GTEx | Thyroid | GOPC | 0.11 | 0.02 | enet | 23 | 0.02 | 1.6e-02 | 3.6 | -5.2 | 1.7e-07 | 0.08 | 0.10 | 0.80 | FALSE |
| 13 | GTEx | Thyroid | DCBLD1 | 0.27 | 0.22 | enet | 14 | 0.24 | 1.3e-18 | -5.7 | -6.4 | 1.2e-10 | 0.03 | 0.39 | 0.61 | FALSE |
| 14 | GTEx | Whole Blood | DCBLD1 | 0.16 | 0.09 | lasso | 7 | 0.09 | 7.7e-09 | -4.9 | 5.8 | 4.9e-09 | 0.00 | 0.90 | 0.10 | FALSE |
| 15 | The Cancer Genome Atlas | Glioblastoma Multiforme | FRK | 0.13 | 0.01 | blup | 94 | 0.05 | 1.5e-02 | -5.8 | -5.2 | 1.9e-07 | 0.01 | 0.02 | 0.40 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | DCBLD1 | 0.07 | 0.03 | blup | 84 | 0.04 | 2.4e-05 | 6.5 | -5.1 | 3.0e-07 | 0.00 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | DCBLD1 | 0.30 | 0.19 | blup | 84 | 0.22 | 2.5e-21 | 6.6 | -5.8 | 6.3e-09 | 0.02 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | GOPC | 0.19 | 0.12 | lasso | 11 | 0.12 | 8.4e-12 | 6.6 | -5.9 | 3.3e-09 | 0.01 | 0.01 | 0.99 | FALSE |