Hub : Genes

FOXO3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.124 0.0550 8.2e-03 0.000 NA 0.052 NA 0.02 3.1e-01 NA 3.0e-03 NA 4.7e-02
2 YFS Blood 0.026 0.0091 7.6e-06 0.013 0.014 0.015 0.016 0.02 3.1e-05 1.4e-05 5.7e-06 4.5e-06 3.2e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.8 1.3 2.4 -1.5 -0.5
Bipolar Disorder or Schizophrenia 1.7 4.1 8.2 -0.1 -2.9
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 -0.9 0.2
Depression (Nagel 2018) 0.5 0.7 1.5 -0.1 -1.2
Intelligence (Savage-Jansen 2018) 9.2 28.4 49.6 -2.7 7.0
Neuroticism (Nagel 2018) 0.6 1.4 1.7 -1.0 -1.3
Schizophrenia (2018) 2.9 6.0 10.7 1.1 -3.3
Schizophrenia vs Biploar Disorder 1.3 1.7 2.4 1.0 -1.6
Worry (Nagel 2018) 3.8 8.0 15.8 0.5 -4.0
Alzheimer’s Disease (in mother) 1.6 1.9 3.6 -0.4 1.9
Alzheimer’s Disease (in father) 0.7 0.7 1.0 1.0 0.6
Alzheimer’s Disease (including proxy) 2.6 3.7 6.6 -1.0 2.6
Crohns Disease (2017) 0.3 0.6 1.1 -1.0 -0.4
Irritable Bowel Disease (IBD) 0.2 0.5 0.9 1.0 0.3
Ulcerative Colitis (UC) 1.0 1.9 2.9 1.7 0.9
Major Depression (MDD) 0.2 0.2 0.4 -0.2 0.6
Reaction Time 14.5 27.7 32.9 4.8 -5.7
Verbal and Numeric Reasoning (VNR) 9.2 22.0 40.0 -2.0 6.3
Breast Cancer 0.1 0.2 0.2 0.5 -0.4
Ovarian Cancer 0.0 0.0 0.0 -0.1 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.0 0.1 0.1 0.1 -0.3
Bipolar Disorder (2011) 0.3 0.3 0.7 -0.0 -0.8
Body Mass Index (BMI) (2010) 4.0 5.5 10.9 -0.3 3.3
Coronary Artery Disease (CAD) 3.0 3.6 6.8 0.5 2.6
Crohns Disease (2012) 0.6 1.0 1.9 -1.4 -0.4
Mean Putamen Volume 1.3 1.5 2.7 -0.5 1.6
Fasting Glucose 0.1 0.1 0.3 -0.0 -0.5
HbA1C 0.7 0.8 1.6 0.2 1.3
HDL Cholesterol 4.7 7.9 9.0 2.6 -3.0
LDL Cholesterol 0.2 0.4 0.8 0.9 -0.0
Lupus 0.6 0.9 1.4 0.6 -1.2
Neuroticism (2016) 0.7 1.0 1.6 1.3 -0.7
Primary Biliary Cirrhosis 0.4 0.6 1.2 1.1 -0.2
Rheumatoid Arthritis 0.0 0.0 0.0 0.1 0.1
Schizophrenia (2014) 1.8 4.1 8.0 -0.4 -2.8
Triglycerides 1.0 1.6 3.3 -0.1 1.8
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.1 -0.2 0.3
Ulcerative Colitis 0.1 0.2 0.3 0.5 0.2
Blood Eosinophil Count 0.1 0.6 0.9 0.6 -0.9
Blood Platelet Count 0.5 6.2 9.7 -3.1 1.6
Blood Red Count 0.3 2.7 2.8 1.7 -1.6
Blood White Count 0.4 2.7 4.1 -2.0 1.1
Heel T-Score 1.3 10.1 15.7 4.0 -2.1
BMI 7.0 40.4 69.7 -3.3 8.3
Height 4.5 87.1 88.2 -9.3 9.4
Waist Hip Ratio (WHR) 2.7 12.1 21.2 -4.6 1.7
Systolic Blood Pressure 3.5 17.7 19.4 4.0 -4.4
Smoking Status 1.1 2.7 5.4 0.2 2.3
Allergy or Eczema 2.5 6.7 13.3 0.1 3.6
Cardiovascular Disease 0.1 0.2 0.4 -0.4 0.6
Hypothyroidism (self reported) 0.3 0.8 1.6 -0.1 1.2
Respiratory disease 0.4 0.9 1.4 1.2 0.6
Type 2 Diabetes (T2D) (2018) 0.9 1.7 2.9 -0.6 1.7
Lung FEV1/FVC ratio 8.3 42.2 52.4 -5.7 7.2
Lung FVC 2.8 14.4 28.2 0.9 -5.3
Neuroticism 0.3 0.7 1.2 -1.1 -0.5
Chronotype (morning person) 0.8 1.8 2.0 1.4 -1.3
Hair Pigment 0.5 13.8 26.3 1.1 -5.1
Tanning 0.0 0.1 0.1 -0.2 0.3
Hand grip strength (left) 0.2 0.6 1.1 -1.0 0.4
Number of treatments/medications taken 2.1 3.8 5.9 -1.3 2.4
Average weekly spirits intake 6.2 7.7 13.1 -1.5 3.6
Sensitivity / hurt feelings 0.6 1.0 1.2 -1.1 0.9
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 0.0 -0.2
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.5 -0.2
Relative age of first facial hair 5.5 11.4 22.8 0.2 -4.8
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 4.7 0.5 2.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 -0.6 0.2
Ever had hysterectomy (womb removed) 0.6 0.7 0.9 0.7 -0.9
Systolic blood pressure, automated reading 1.6 4.8 6.1 1.9 -2.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.3 -0.3 1.1
Angina 0.2 0.3 0.4 0.4 0.7
Medication for hormone replacement therapy 0.8 0.9 0.9 1.0 0.9
Vitamin and mineral supplements 1.0 1.4 2.7 -0.1 -1.6
Supplements: Zinc 1.9 2.1 4.1 -0.0 2.0
Medication: Co-codamol 0.5 0.6 1.1 1.1 -0.3
Medication: Metformin 0.5 0.7 1.1 -0.5 1.1
Diabetes (father) 0.5 0.6 1.1 -0.4 1.0
Diabetes (mother) 0.3 0.3 0.4 -0.7 0.5
Severe depression (siblings) 1.3 1.4 2.5 -1.6 -0.6
Pack years adult smoking proportion 0.1 0.2 0.3 0.4 0.5
Impedance of leg (right) 2.1 10.2 15.5 2.2 -3.9
Leg fat-free mass (left) 9.8 52.1 71.7 -5.7 8.5
Trunk fat percentage 2.9 11.8 22.1 -1.2 4.7
Hand grip strength (right) 0.1 0.3 0.5 -0.7 0.4
Townsend deprivation index at recruitment 0.5 0.7 1.1 1.1 -0.5
Current tobacco smoking 1.5 2.4 4.4 2.1 -0.6
Average weekly fortified wine intake 3.7 4.3 4.5 -2.1 2.0
Maternal smoking around birth 1.0 1.4 1.7 1.0 1.3
Fed-up feelings 0.5 1.0 1.9 -0.2 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.5 0.5 -0.7
Relative age voice broke 7.0 10.7 21.4 0.2 -4.6
Taking other prescription medications 0.7 1.1 2.2 0.0 1.5
Age when periods started (menarche) 5.9 14.3 27.7 -0.9 -5.3
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 2.8 0.8 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.6 1.6 0.2
Tinnitus: Yes, but not now, but have in the past 3.2 3.4 3.9 -2.0 -1.7
Qualifications: CSEs or equivalent 0.2 0.2 0.5 0.1 0.7
Serious illness, injury or assault to yourself 0.5 0.6 1.0 0.4 -1.0
High blood pressure 0.1 0.4 0.7 0.3 -0.9
Hayfever, allergic rhinitis or eczema 2.7 5.9 10.9 1.0 3.3
Multivitamins +/- minerals 2.5 3.2 6.1 0.5 2.5
Stomach or abdominal pain in last month 0.8 1.0 2.0 0.1 1.4
Supplements: Glucosamine 0.8 1.1 2.2 0.1 1.5
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 3.0 -1.1 1.7
Medication: Atenolol 1.2 1.5 2.4 1.6 0.7
Medication: Levothyroxine sodium 1.1 1.9 2.9 -0.9 1.7
Sitting height 7.0 49.9 59.4 -6.3 7.7
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.2 -0.2
High blood pressure (mother) 0.6 0.8 1.4 1.2 -0.5
Body mass index (BMI) 4.3 18.5 33.4 -1.9 5.8
Impedance of leg (left) 1.9 9.2 12.5 2.4 -3.5
Leg predicted mass (left) 9.8 52.1 72.1 -5.7 8.5
Trunk fat mass 6.5 27.7 47.1 -2.9 6.9
Waist circumference 8.1 29.8 44.2 -3.9 6.6
Number of incorrect matches in round 0.7 1.1 1.1 -1.1 -1.0
Past tobacco smoking 3.0 5.5 6.9 2.0 -2.6
Alcohol usually taken with meals 0.1 0.1 0.3 0.2 0.5
Nervous feelings 2.7 5.0 8.8 1.1 -3.0
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.2 3.6 1.9 -1.7
Hearing difficulty/problems with background noise 0.7 1.1 2.2 0.1 -1.5
Hair/balding pattern: Pattern 2 1.8 2.3 2.7 1.3 -1.6
Had menopause 2.4 3.0 4.6 1.2 -2.1
Had other major operations 5.0 6.1 10.4 -1.4 3.2
Forced vital capacity (FVC) 0.2 0.6 1.1 -1.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.7 1.9 -0.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 0.9 -0.1
Qualifications: None of the above 6.8 14.5 26.1 1.7 -5.1
Financial difficulties in last 2 years 1.1 1.4 1.5 1.2 -1.2
Mouth/teeth dental problems 0.6 1.0 1.9 0.0 1.4
Heart attack 0.7 0.9 1.8 -1.4 0.0
Allergy 2.1 4.7 6.8 -1.6 -2.6
Pain all over the body in last month 1.2 1.3 2.4 0.5 -1.5
Diabetes (self-reported) 0.6 0.9 1.8 -0.1 1.4
Hayfever/allergic rhinitis (self-reported) 2.9 3.9 7.6 -0.4 2.7
Medication: Ramipril 0.7 1.0 1.8 1.3 0.3
Medication: Simvastatin 0.3 0.5 1.0 -1.0 0.0
Fluid intelligence score 8.3 17.1 30.5 -1.9 5.5
Illnesses of siblings 0.7 1.0 2.0 1.4 -0.4
Neuroticism score 0.4 0.7 1.0 -1.0 -0.7
Weight 10.4 51.2 78.7 -4.9 8.9
Impedance of arm (right) 5.0 23.4 31.3 4.0 -5.6
Arm fat percentage (right) 2.4 9.6 18.9 -0.5 4.3
Trunk fat-free mass 11.2 64.1 84.8 -6.6 9.2
Hip circumference 6.5 27.8 50.3 -2.3 7.1
Time employed in main current job 1.3 1.5 3.0 -1.7 -0.1
Alcohol intake versus 10 years previously 0.7 1.1 2.0 -1.4 0.4
Father’s age at death 0.3 0.4 0.8 0.0 -0.9
Worrier / anxious feelings 0.8 1.6 2.0 1.1 -1.4
Frequency of tiredness / lethargy in last 2 weeks 2.4 3.9 7.4 0.6 2.7
Falls in the last year 1.3 1.7 3.2 -0.4 1.8
Hair/balding pattern: Pattern 3 0.7 1.1 2.1 -0.3 1.4
Number of live births 0.2 0.3 0.5 0.4 0.7
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 3.4 -1.8 1.8
Pulse rate 0.4 0.7 1.2 -0.5 1.1
Happiness 0.0 0.0 0.0 0.1 0.0
Noisy workplace 0.3 0.3 0.4 -0.6 0.5
Qualifications: A levels/AS levels or equivalent 2.2 4.8 9.4 -0.5 3.1
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.1 0.1 0.0 0.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 -0.5 0.3
Asthma 0.3 0.6 0.7 0.8 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 1.7 -1.1 1.3
Medication: Cholesterol lowering 1.1 1.8 2.0 -1.4 1.2
Depression (self-reported) 0.5 0.6 0.7 -0.7 -0.8
Medication: Lansoprazole 1.3 1.5 2.9 -1.7 0.1
Prospective memory result 2.0 2.5 2.9 -1.7 -1.5
Lung cancer (father) 0.0 0.0 0.1 0.3 -0.0
Illnesses of mother 0.1 0.1 0.2 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 4.4 -2.1 1.4
Pulse wave Arterial Stiffness index 3.0 3.6 6.4 -2.5 0.9
Impedance of arm (left) 5.6 25.8 35.4 4.0 -6.0
Arm fat mass (right) 6.2 25.4 45.2 -2.4 6.7
Trunk predicted mass 11.4 65.2 87.2 -6.6 9.3
Standing height 5.3 52.1 56.1 -6.9 7.5
Length of working week for main job 1.3 1.5 2.0 1.4 1.0
Exposure to tobacco smoke at home 0.6 0.7 1.3 -1.1 -0.3
Breastfed as a baby 3.2 4.0 8.0 -0.3 2.8
Tense / ‘highly strung’ 0.3 0.5 0.9 0.3 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 0.8 -0.9 -0.8
Hair/balding pattern: Pattern 4 0.2 0.4 0.8 0.9 -0.0
Birth weight of first child 1.9 3.5 7.0 -0.1 2.6
Peak expiratory flow (PEF) 4.3 9.9 18.8 -1.0 4.3
Pulse wave reflection index 0.5 0.6 1.1 -1.1 -0.4
Ever highly irritable/argumentative for 2 days 0.8 1.0 1.3 0.8 1.1
Loud music exposure frequency 0.8 0.9 1.7 -0.4 1.3
Qualifications: O levels/GCSEs or equivalent 4.8 7.7 13.6 -1.3 3.7
Mouth/teeth dental problems: Bleeding gums 3.3 4.3 8.5 0.3 -2.9
Blood clot in the leg (DVT) 0.1 0.2 0.2 -0.3 0.5
Medication: Paracetamol 1.0 1.7 3.0 -1.7 0.6
Headache pain in last month 1.2 2.0 2.9 1.7 1.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.2 1.1 -0.6
Glaucoma (self-reported) 2.5 2.9 5.8 -0.3 2.4
Gout (self-reported) 0.5 0.6 0.8 0.7 -0.9
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.3 -0.8 1.1
Medication: Amlodipine 0.1 0.2 0.3 0.5 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.4 0.6 0.5
Birth weight 0.3 0.7 1.4 -0.1 1.2
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 0.6 0.1
High blood pressure (siblings) 1.0 1.4 2.4 -1.6 -0.6
Forced vital capacity (FVC), Best measure 0.4 1.4 2.6 -1.6 0.5
Body fat percentage 3.2 12.8 24.1 -1.2 4.9
Leg fat percentage (right) 2.7 9.9 17.7 -1.4 4.2
Arm fat-free mass (right) 12.3 63.1 85.4 -6.4 9.2
Exposure to tobacco smoke outside home 1.4 1.9 3.8 0.1 -2.0
Comparative body size at age 10 1.4 3.9 7.8 0.2 2.8
Number of full brothers 0.1 0.1 0.1 -0.3 -0.3
Worry too long after embarrassment 0.5 0.9 1.6 -1.3 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 2.7 1.6 -0.5
Wheeze or whistling in the chest in last year 0.3 0.6 1.2 1.1 0.2
Number of children fathered 1.9 2.2 3.3 -1.1 1.8
Reason for reducing amount of alcohol drunk: Health precaution 3.1 3.7 4.7 -1.6 2.2
Age at first live birth 2.8 5.1 6.6 -1.9 2.6
Pulse wave peak to peak time 1.9 2.3 4.3 2.1 -0.5
Health satisfaction 0.8 1.1 1.7 0.6 1.3
Shortness of breath walking on level ground 1.1 1.3 2.2 1.5 -0.6
Qualifications: College or University degree 6.1 19.3 38.2 -0.7 6.2
Eye problems/disorders: None of the above 2.2 2.5 5.0 0.1 -2.2
Mouth/teeth dental problems: Loose teeth 2.2 2.6 5.2 -2.3 0.1
Emphysema/chronic bronchitis 0.4 0.4 0.7 0.3 -0.8
Medication for pain relief, constipation, heartburn 1.8 3.1 3.4 1.7 -1.8
Neck or shoulder pain in last month 0.7 1.0 1.3 0.8 1.1
Medication: Blood pressure 0.0 0.1 0.2 -0.1 0.4
Angina (self-reported) 0.1 0.2 0.2 0.3 0.5
Migraine (self-reported) 0.3 0.4 0.7 0.8 0.1
Medication: Ibuprofen 2.3 2.8 4.4 -1.1 2.1
Medication: Allopurinol 0.7 1.0 1.1 1.0 -0.9
Medication: Omeprazole 0.5 0.6 0.8 -0.9 -0.6
Medication: Seretide 50 evohaler 0.3 0.3 0.4 0.6 0.5
Mean time to correctly identify matches 13.4 25.6 34.5 4.1 -5.9
Heart disease (mother) 0.2 0.2 0.3 -0.5 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 -0.3 -0.6
Whole body fat mass 6.9 28.9 50.0 -2.8 7.1
Leg fat mass (right) 7.3 28.2 45.4 -3.3 6.7
Arm predicted mass (right) 12.2 62.5 86.5 -6.2 9.3
Pulse rate, automated reading 0.2 0.7 0.8 -0.8 0.9
Alcohol intake frequency. 1.5 3.5 5.4 2.3 -1.3
Comparative height size at age 10 5.2 28.8 34.3 -4.8 5.9
Number of full sisters 0.7 0.8 1.6 -0.1 1.3
Suffer from ‘nerves’ 3.9 6.1 12.2 0.1 -3.5
Overall health rating 0.1 0.3 0.4 0.4 0.6
Chest pain or discomfort 0.3 0.5 0.6 0.6 -0.7
Had major operations 0.2 0.3 0.6 -0.8 0.0
Age at last live birth 1.8 2.7 5.0 -0.6 2.2
Family relationship satisfaction 0.5 0.6 1.0 -0.4 -1.0
Leg pain on walking 0.1 0.1 0.1 0.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.5 -1.2 -0.1
Commuting to job workplace: Car/motor vehicle 2.4 2.8 4.0 -2.0 1.2
Illness, injury, bereavement, stress in last 2 years 3.3 4.1 4.3 -2.0 2.1
Medication: Aspirin 0.7 1.0 1.5 -0.6 1.2
Supplements: Vitamin C 1.5 1.8 2.7 -1.6 1.0
Knee pain experienced in last month 0.2 0.3 0.6 0.1 0.8
Hypertension (Self-reported) 0.3 0.8 1.5 0.1 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.8 0.2
Illnesses of father: Heart disease 2.6 3.7 6.8 -0.7 2.6
Illnesses of siblings: Diabetes 0.4 0.5 1.0 1.0 0.1
Smoking status: Previous 2.7 4.0 4.9 -1.8 2.2
Forced expiratory volume in 1-second (FEV1), predicted 3.9 8.0 9.0 -2.7 3.0
Whole body fat-free mass 11.6 66.1 89.7 -6.5 9.5
Leg fat-free mass (right) 9.5 50.6 72.1 -5.4 8.5
Arm fat percentage (left) 2.0 7.8 15.4 -0.5 3.9
Average weekly red wine intake 0.9 1.4 1.4 -1.1 1.2
Handedness (chirality/laterality): Left-handed 2.6 3.1 3.5 -1.6 1.9
Mood swings 0.0 0.0 0.1 -0.0 -0.3
Loneliness, isolation 0.2 0.2 0.4 -0.6 0.2
Long-standing illness, disability or infirmity 0.8 1.3 2.2 0.6 1.5
Ever had bowel cancer screening 0.9 1.0 1.9 -1.4 -0.3
Diabetes diagnosed by doctor 0.9 1.5 2.2 -0.9 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 0.5 0.1
Friendships satisfaction 1.0 1.3 2.5 -0.3 -1.6
Qualifications: nursing, teaching 1.0 1.5 2.9 1.7 0.3
Commuting to job workplace: Walk 0.5 0.5 0.8 0.9 0.4
Eye problems/disorders: Cataract 0.5 0.6 0.8 0.6 0.9
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 4.2 -0.3 -2.1
Medication for cholesterol 0.3 0.4 0.7 0.2 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 0.1 0.9
Back pain experienced in last month 2.1 3.0 6.0 -0.1 2.5
Mineral and other dietary supplements 0.6 0.8 0.9 -0.8 -0.9
Breast cancer (self-reported) 1.3 1.6 3.1 0.2 -1.8
Asthma (self-reported) 0.2 0.5 0.7 0.9 0.5
Osteoporosis (self-reported) 1.0 1.2 1.6 -0.9 -1.2
Osteoarthritis (self-reported) 1.4 1.8 3.6 0.1 1.9
Medication: Aspirin 1.1 1.4 2.1 -0.8 1.4
Medication: Gliclazide 0.6 0.7 1.2 -0.5 1.1
Illnesses of father: None of the above (group 1) 0.5 0.6 0.7 -0.8 -0.7
Smoking status: Current 0.6 1.0 1.8 1.3 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.5 0.0 -1.2
Whole body water mass 11.5 65.3 90.6 -6.3 9.5
Leg predicted mass (right) 9.5 50.8 72.5 -5.4 8.5
Arm fat mass (left) 5.7 23.5 42.1 -2.2 6.5
Number of self-reported non-cancer illnesses 1.7 2.9 4.8 -1.0 2.2
Average weekly champagne plus white wine intake 1.5 2.0 3.3 -0.9 1.8
Miserableness 0.6 1.1 1.2 -1.1 0.9
Guilty feelings 0.5 0.8 1.2 -1.1 0.6
Wears glasses or contact lenses 0.8 0.9 1.0 1.0 0.9
Ever taken oral contraceptive pill 2.0 2.3 4.5 -2.1 -0.3
Hearing aid user 0.9 1.0 1.0 -1.0 1.0
Mother’s age at death 0.3 0.4 0.6 -0.8 -0.4
Financial situation satisfaction 0.0 0.0 0.0 -0.1 -0.2
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.7 -0.8 0.3
Commuting to job workplace: Public transport 0.8 0.9 1.7 1.3 -0.3
Eye problems/disorders: Glaucoma 2.6 3.1 6.0 -0.5 2.4
Medication: Blood pressure 0.6 1.2 1.7 0.8 -1.3
Pain type(s) experienced in last month: Hip pain 2.0 2.6 4.9 -0.5 2.2
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.4 0.6 0.4
High cholesterol (Self-reported) 0.6 1.1 1.9 -1.4 0.5
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.4 -0.2
Medication: Paracetamol 1.3 2.0 3.6 -1.9 0.6
Medication: Lisinopril 0.1 0.1 0.2 0.0 -0.4
Medication: Atorvastatin 1.0 1.2 2.1 -1.4 0.6
Illnesses of father: High blood pressure 0.2 0.2 0.5 -0.7 -0.1
Alcohol drinker status: Never 0.8 0.9 1.8 0.3 -1.3
Ever smoked 2.0 3.5 3.8 -2.0 1.8
Basal metabolic rate 11.8 65.4 92.4 -6.2 9.6
Leg fat percentage (left) 3.1 11.1 20.1 -1.4 4.5
Arm fat-free mass (left) 13.4 68.0 95.6 -6.3 9.8
Number of operations (self-reported) 3.8 5.6 8.0 -1.8 2.8
Average weekly beer plus cider intake 0.6 0.9 1.7 -0.2 -1.3
Irritability 1.6 2.7 4.2 -2.0 1.1
Risk taking 0.3 0.4 0.8 -0.9 -0.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 0.9 -0.8 -0.9
Fractured/broken bones in last 5 years 0.7 0.9 1.6 0.4 1.3
Age started oral contraceptive pill 1.6 2.0 2.1 -1.5 -1.3
Diastolic blood pressure, automated reading 0.1 0.4 0.8 0.9 0.2
Ever depressed for a whole week 0.6 0.7 1.2 0.5 1.1
Unable to work because of sickness or disability 2.0 2.6 5.2 2.3 0.1
Commuting to job workplace: Cycle 0.6 0.7 1.4 0.1 -1.2
Myopia 0.5 0.7 1.4 1.2 0.1
Vascular/heart problems diagnosed by doctor 0.2 0.7 1.0 -0.6 1.0
Cholesterol lowering medication 0.6 0.8 1.7 -1.3 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.8 -0.9 -0.1
Pain experienced in last month 0.4 0.7 1.4 0.2 -1.2
Supplements: Calcium 0.3 0.4 0.7 0.2 0.8
Basal cell carcinoma (self-reported) 3.2 3.8 6.7 1.0 2.6
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.0 -1.0 -0.0
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.4 -0.3 0.7
Heart disease (siblings) 1.6 2.0 2.3 -1.5 1.3
Alcohol drinker status: Previous 1.0 1.2 1.7 0.8 -1.3
Pack years of smoking 0.1 0.1 0.2 0.4 0.2
Impedance of whole body 4.3 22.1 30.6 3.7 -5.5
Leg fat mass (left) 7.5 29.1 47.7 -3.2 6.9
Arm predicted mass (left) 13.1 66.4 91.6 -6.4 9.6