TWAS hub - FOXO3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.124	0.0550	8.2e-03	0.000	NA	0.052	NA	0.02	3.1e-01	NA	3.0e-03	NA	4.7e-02
2	YFS	Blood	0.026	0.0091	7.6e-06	0.013	0.014	0.015	0.016	0.02	3.1e-05	1.4e-05	5.7e-06	4.5e-06	3.2e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Reaction Time	14.5	27.7	32.9	4.8	-5.7
Mean time to correctly identify matches	13.4	25.6	34.5	4.1	-5.9
Arm fat-free mass (left)	13.4	68.0	95.6	-6.3	9.8
Arm predicted mass (left)	13.1	66.4	91.6	-6.4	9.6
Arm fat-free mass (right)	12.3	63.1	85.4	-6.4	9.2
Arm predicted mass (right)	12.2	62.5	86.5	-6.2	9.3
Basal metabolic rate	11.8	65.4	92.4	-6.2	9.6
Whole body fat-free mass	11.6	66.1	89.7	-6.5	9.5
Whole body water mass	11.5	65.3	90.6	-6.3	9.5
Trunk predicted mass	11.4	65.2	87.2	-6.6	9.3
Trunk fat-free mass	11.2	64.1	84.8	-6.6	9.2
Weight	10.4	51.2	78.7	-4.9	8.9
Leg fat-free mass (left)	9.8	52.1	71.7	-5.7	8.5
Leg predicted mass (left)	9.8	52.1	72.1	-5.7	8.5
Leg fat-free mass (right)	9.5	50.6	72.1	-5.4	8.5
Leg predicted mass (right)	9.5	50.8	72.5	-5.4	8.5
Intelligence (Savage-Jansen 2018)	9.2	28.4	49.6	-2.7	7.0
Verbal and Numeric Reasoning (VNR)	9.2	22.0	40.0	-2.0	6.3
Lung FEV1/FVC ratio	8.3	42.2	52.4	-5.7	7.2
Fluid intelligence score	8.3	17.1	30.5	-1.9	5.5
Waist circumference	8.1	29.8	44.2	-3.9	6.6
Leg fat mass (left)	7.5	29.1	47.7	-3.2	6.9
Leg fat mass (right)	7.3	28.2	45.4	-3.3	6.7
BMI	7.0	40.4	69.7	-3.3	8.3
Relative age voice broke	7.0	10.7	21.4	0.2	-4.6
Sitting height	7.0	49.9	59.4	-6.3	7.7
Whole body fat mass	6.9	28.9	50.0	-2.8	7.1
Qualifications: None of the above	6.8	14.5	26.1	1.7	-5.1
Trunk fat mass	6.5	27.7	47.1	-2.9	6.9
Hip circumference	6.5	27.8	50.3	-2.3	7.1
Average weekly spirits intake	6.2	7.7	13.1	-1.5	3.6
Arm fat mass (right)	6.2	25.4	45.2	-2.4	6.7
Qualifications: College or University degree	6.1	19.3	38.2	-0.7	6.2
Age when periods started (menarche)	5.9	14.3	27.7	-0.9	-5.3
Arm fat mass (left)	5.7	23.5	42.1	-2.2	6.5
Impedance of arm (left)	5.6	25.8	35.4	4.0	-6.0
Relative age of first facial hair	5.5	11.4	22.8	0.2	-4.8
Standing height	5.3	52.1	56.1	-6.9	7.5
Comparative height size at age 10	5.2	28.8	34.3	-4.8	5.9
Had other major operations	5.0	6.1	10.4	-1.4	3.2
Impedance of arm (right)	5.0	23.4	31.3	4.0	-5.6
Qualifications: O levels/GCSEs or equivalent	4.8	7.7	13.6	-1.3	3.7
HDL Cholesterol	4.7	7.9	9.0	2.6	-3.0
Height	4.5	87.1	88.2	-9.3	9.4
Body mass index (BMI)	4.3	18.5	33.4	-1.9	5.8
Peak expiratory flow (PEF)	4.3	9.9	18.8	-1.0	4.3
Impedance of whole body	4.3	22.1	30.6	3.7	-5.5
Body Mass Index (BMI) (2010)	4.0	5.5	10.9	-0.3	3.3
Suffer from ‘nerves’	3.9	6.1	12.2	0.1	-3.5
Forced expiratory volume in 1-second (FEV1), predicted	3.9	8.0	9.0	-2.7	3.0
Worry (Nagel 2018)	3.8	8.0	15.8	0.5	-4.0
Number of operations (self-reported)	3.8	5.6	8.0	-1.8	2.8
Average weekly fortified wine intake	3.7	4.3	4.5	-2.1	2.0
Systolic Blood Pressure	3.5	17.7	19.4	4.0	-4.4
Mouth/teeth dental problems: Bleeding gums	3.3	4.3	8.5	0.3	-2.9
Illness, injury, bereavement, stress in last 2 years	3.3	4.1	4.3	-2.0	2.1
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	3.9	-2.0	-1.7
Breastfed as a baby	3.2	4.0	8.0	-0.3	2.8
Body fat percentage	3.2	12.8	24.1	-1.2	4.9
Basal cell carcinoma (self-reported)	3.2	3.8	6.7	1.0	2.6
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.7	4.7	-1.6	2.2
Leg fat percentage (left)	3.1	11.1	20.1	-1.4	4.5
Coronary Artery Disease (CAD)	3.0	3.6	6.8	0.5	2.6
Past tobacco smoking	3.0	5.5	6.9	2.0	-2.6
Pulse wave Arterial Stiffness index	3.0	3.6	6.4	-2.5	0.9
Schizophrenia (2018)	2.9	6.0	10.7	1.1	-3.3
Trunk fat percentage	2.9	11.8	22.1	-1.2	4.7
Hayfever/allergic rhinitis (self-reported)	2.9	3.9	7.6	-0.4	2.7
Lung FVC	2.8	14.4	28.2	0.9	-5.3
Age at first live birth	2.8	5.1	6.6	-1.9	2.6
Waist Hip Ratio (WHR)	2.7	12.1	21.2	-4.6	1.7
Hayfever, allergic rhinitis or eczema	2.7	5.9	10.9	1.0	3.3
Nervous feelings	2.7	5.0	8.8	1.1	-3.0
Leg fat percentage (right)	2.7	9.9	17.7	-1.4	4.2
Smoking status: Previous	2.7	4.0	4.9	-1.8	2.2
Alzheimer’s Disease (including proxy)	2.6	3.7	6.6	-1.0	2.6
Illnesses of father: Heart disease	2.6	3.7	6.8	-0.7	2.6
Handedness (chirality/laterality): Left-handed	2.6	3.1	3.5	-1.6	1.9
Eye problems/disorders: Glaucoma	2.6	3.1	6.0	-0.5	2.4
Allergy or Eczema	2.5	6.7	13.3	0.1	3.6
Multivitamins +/- minerals	2.5	3.2	6.1	0.5	2.5
Glaucoma (self-reported)	2.5	2.9	5.8	-0.3	2.4
Had menopause	2.4	3.0	4.6	1.2	-2.1
Arm fat percentage (right)	2.4	9.6	18.9	-0.5	4.3
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	7.4	0.6	2.7
Commuting to job workplace: Car/motor vehicle	2.4	2.8	4.0	-2.0	1.2
Medication: Ibuprofen	2.3	2.8	4.4	-1.1	2.1
Qualifications: A levels/AS levels or equivalent	2.2	4.8	9.4	-0.5	3.1
Eye problems/disorders: None of the above	2.2	2.5	5.0	0.1	-2.2
Mouth/teeth dental problems: Loose teeth	2.2	2.6	5.2	-2.3	0.1
Number of treatments/medications taken	2.1	3.8	5.9	-1.3	2.4
Impedance of leg (right)	2.1	10.2	15.5	2.2	-3.9
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.2	3.6	1.9	-1.7
Allergy	2.1	4.7	6.8	-1.6	-2.6
Back pain experienced in last month	2.1	3.0	6.0	-0.1	2.5
Prospective memory result	2.0	2.5	2.9	-1.7	-1.5
Arm fat percentage (left)	2.0	7.8	15.4	-0.5	3.9
Ever taken oral contraceptive pill	2.0	2.3	4.5	-2.1	-0.3
Pain type(s) experienced in last month: Hip pain	2.0	2.6	4.9	-0.5	2.2
Ever smoked	2.0	3.5	3.8	-2.0	1.8
Unable to work because of sickness or disability	2.0	2.6	5.2	2.3	0.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.7	0.5	2.2
Supplements: Zinc	1.9	2.1	4.1	-0.0	2.0
Impedance of leg (left)	1.9	9.2	12.5	2.4	-3.5
Birth weight of first child	1.9	3.5	7.0	-0.1	2.6
Number of children fathered	1.9	2.2	3.3	-1.1	1.8
Pulse wave peak to peak time	1.9	2.3	4.3	2.1	-0.5
Schizophrenia (2014)	1.8	4.1	8.0	-0.4	-2.8
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	3.0	-1.1	1.7
Hair/balding pattern: Pattern 2	1.8	2.3	2.7	1.3	-1.6
Medication for pain relief, constipation, heartburn	1.8	3.1	3.4	1.7	-1.8
Age at last live birth	1.8	2.7	5.0	-0.6	2.2
Bipolar Disorder or Schizophrenia	1.7	4.1	8.2	-0.1	-2.9
Number of self-reported non-cancer illnesses	1.7	2.9	4.8	-1.0	2.2
Alzheimer’s Disease (in mother)	1.6	1.9	3.6	-0.4	1.9
Systolic blood pressure, automated reading	1.6	4.8	6.1	1.9	-2.5
Irritability	1.6	2.7	4.2	-2.0	1.1
Age started oral contraceptive pill	1.6	2.0	2.1	-1.5	-1.3
Heart disease (siblings)	1.6	2.0	2.3	-1.5	1.3
Current tobacco smoking	1.5	2.4	4.4	2.1	-0.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.8	0.8	1.7
Alcohol intake frequency.	1.5	3.5	5.4	2.3	-1.3
Supplements: Vitamin C	1.5	1.8	2.7	-1.6	1.0
Average weekly champagne plus white wine intake	1.5	2.0	3.3	-0.9	1.8
Exposure to tobacco smoke outside home	1.4	1.9	3.8	0.1	-2.0
Comparative body size at age 10	1.4	3.9	7.8	0.2	2.8
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.2	-0.3	-2.1
Osteoarthritis (self-reported)	1.4	1.8	3.6	0.1	1.9
Schizophrenia vs Biploar Disorder	1.3	1.7	2.4	1.0	-1.6
Mean Putamen Volume	1.3	1.5	2.7	-0.5	1.6
Heel T-Score	1.3	10.1	15.7	4.0	-2.1
Severe depression (siblings)	1.3	1.4	2.5	-1.6	-0.6
Time employed in main current job	1.3	1.5	3.0	-1.7	-0.1
Falls in the last year	1.3	1.7	3.2	-0.4	1.8
Medication: Lansoprazole	1.3	1.5	2.9	-1.7	0.1
Length of working week for main job	1.3	1.5	2.0	1.4	1.0
Breast cancer (self-reported)	1.3	1.6	3.1	0.2	-1.8
Medication: Paracetamol	1.3	2.0	3.6	-1.9	0.6
Medication: Atenolol	1.2	1.5	2.4	1.6	0.7
Pain all over the body in last month	1.2	1.3	2.4	0.5	-1.5
Headache pain in last month	1.2	2.0	2.9	1.7	1.1
Smoking Status	1.1	2.7	5.4	0.2	2.3
Medication: Levothyroxine sodium	1.1	1.9	2.9	-0.9	1.7
Financial difficulties in last 2 years	1.1	1.4	1.5	1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.7	-1.1	1.3
Medication: Cholesterol lowering	1.1	1.8	2.0	-1.4	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	2.7	1.6	-0.5
Shortness of breath walking on level ground	1.1	1.3	2.2	1.5	-0.6
Medication: Aspirin	1.1	1.4	2.1	-0.8	1.4
Ulcerative Colitis (UC)	1.0	1.9	2.9	1.7	0.9
Triglycerides	1.0	1.6	3.3	-0.1	1.8
Vitamin and mineral supplements	1.0	1.4	2.7	-0.1	-1.6
Maternal smoking around birth	1.0	1.4	1.7	1.0	1.3
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	3.4	-1.8	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	4.4	-2.1	1.4
Medication: Paracetamol	1.0	1.7	3.0	-1.7	0.6
High blood pressure (siblings)	1.0	1.4	2.4	-1.6	-0.6
Friendships satisfaction	1.0	1.3	2.5	-0.3	-1.6
Qualifications: nursing, teaching	1.0	1.5	2.9	1.7	0.3
Osteoporosis (self-reported)	1.0	1.2	1.6	-0.9	-1.2
Medication: Atorvastatin	1.0	1.2	2.1	-1.4	0.6
Alcohol drinker status: Previous	1.0	1.2	1.7	0.8	-1.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	2.9	-0.6	1.7
Average weekly red wine intake	0.9	1.4	1.4	-1.1	1.2
Ever had bowel cancer screening	0.9	1.0	1.9	-1.4	-0.3
Diabetes diagnosed by doctor	0.9	1.5	2.2	-0.9	1.5
Hearing aid user	0.9	1.0	1.0	-1.0	1.0
Bipolar Disorder (2018)	0.8	1.3	2.4	-1.5	-0.5
Chronotype (morning person)	0.8	1.8	2.0	1.4	-1.3
Medication for hormone replacement therapy	0.8	0.9	0.9	1.0	0.9
Stomach or abdominal pain in last month	0.8	1.0	2.0	0.1	1.4
Supplements: Glucosamine	0.8	1.1	2.2	0.1	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.7	1.9	-0.3
Worrier / anxious feelings	0.8	1.6	2.0	1.1	-1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.3	0.8	1.1
Loud music exposure frequency	0.8	0.9	1.7	-0.4	1.3
Health satisfaction	0.8	1.1	1.7	0.6	1.3
Long-standing illness, disability or infirmity	0.8	1.3	2.2	0.6	1.5
Wears glasses or contact lenses	0.8	0.9	1.0	1.0	0.9
Commuting to job workplace: Public transport	0.8	0.9	1.7	1.3	-0.3
Alcohol drinker status: Never	0.8	0.9	1.8	0.3	-1.3
Alzheimer’s Disease (in father)	0.7	0.7	1.0	1.0	0.6
HbA1C	0.7	0.8	1.6	0.2	1.3
Neuroticism (2016)	0.7	1.0	1.6	1.3	-0.7
Taking other prescription medications	0.7	1.1	2.2	0.0	1.5
Number of incorrect matches in round	0.7	1.1	1.1	-1.1	-1.0
Hearing difficulty/problems with background noise	0.7	1.1	2.2	0.1	-1.5
Heart attack	0.7	0.9	1.8	-1.4	0.0
Medication: Ramipril	0.7	1.0	1.8	1.3	0.3
Illnesses of siblings	0.7	1.0	2.0	1.4	-0.4
Alcohol intake versus 10 years previously	0.7	1.1	2.0	-1.4	0.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.1	-0.3	1.4
Neck or shoulder pain in last month	0.7	1.0	1.3	0.8	1.1
Medication: Allopurinol	0.7	1.0	1.1	1.0	-0.9
Number of full sisters	0.7	0.8	1.6	-0.1	1.3
Medication: Aspirin	0.7	1.0	1.5	-0.6	1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	0.9	-0.8	-0.9
Fractured/broken bones in last 5 years	0.7	0.9	1.6	0.4	1.3
Neuroticism (Nagel 2018)	0.6	1.4	1.7	-1.0	-1.3
Crohns Disease (2012)	0.6	1.0	1.9	-1.4	-0.4
Lupus	0.6	0.9	1.4	0.6	-1.2
Sensitivity / hurt feelings	0.6	1.0	1.2	-1.1	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	0.7	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.3	-0.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.6	1.6	0.2
High blood pressure (mother)	0.6	0.8	1.4	1.2	-0.5
Mouth/teeth dental problems	0.6	1.0	1.9	0.0	1.4
Diabetes (self-reported)	0.6	0.9	1.8	-0.1	1.4
Exposure to tobacco smoke at home	0.6	0.7	1.3	-1.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	-1.2	-0.1
Mineral and other dietary supplements	0.6	0.8	0.9	-0.8	-0.9
Medication: Gliclazide	0.6	0.7	1.2	-0.5	1.1
Smoking status: Current	0.6	1.0	1.8	1.3	-0.4
Miserableness	0.6	1.1	1.2	-1.1	0.9
Medication: Blood pressure	0.6	1.2	1.7	0.8	-1.3
High cholesterol (Self-reported)	0.6	1.1	1.9	-1.4	0.5
Average weekly beer plus cider intake	0.6	0.9	1.7	-0.2	-1.3
Ever depressed for a whole week	0.6	0.7	1.2	0.5	1.1
Commuting to job workplace: Cycle	0.6	0.7	1.4	0.1	-1.2
Cholesterol lowering medication	0.6	0.8	1.7	-1.3	-0.1
Depression (Nagel 2018)	0.5	0.7	1.5	-0.1	-1.2
Blood Platelet Count	0.5	6.2	9.7	-3.1	1.6
Hair Pigment	0.5	13.8	26.3	1.1	-5.1
Medication: Co-codamol	0.5	0.6	1.1	1.1	-0.3
Medication: Metformin	0.5	0.7	1.1	-0.5	1.1
Diabetes (father)	0.5	0.6	1.1	-0.4	1.0
Townsend deprivation index at recruitment	0.5	0.7	1.1	1.1	-0.5
Fed-up feelings	0.5	1.0	1.9	-0.2	1.4
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.4	-1.0
Depression (self-reported)	0.5	0.6	0.7	-0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	0.8	-0.9	-0.8
Pulse wave reflection index	0.5	0.6	1.1	-1.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.2	1.1	-0.6
Gout (self-reported)	0.5	0.6	0.8	0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.3	-0.8	1.1
Worry too long after embarrassment	0.5	0.9	1.6	-1.3	-0.4
Medication: Omeprazole	0.5	0.6	0.8	-0.9	-0.6
Family relationship satisfaction	0.5	0.6	1.0	-0.4	-1.0
Commuting to job workplace: Walk	0.5	0.5	0.8	0.9	0.4
Eye problems/disorders: Cataract	0.5	0.6	0.8	0.6	0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	-0.8	-0.7
Guilty feelings	0.5	0.8	1.2	-1.1	0.6
Myopia	0.5	0.7	1.4	1.2	0.1
Primary Biliary Cirrhosis	0.4	0.6	1.2	1.1	-0.2
Blood White Count	0.4	2.7	4.1	-2.0	1.1
Respiratory disease	0.4	0.9	1.4	1.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.9	-0.1
Neuroticism score	0.4	0.7	1.0	-1.0	-0.7
Pulse rate	0.4	0.7	1.2	-0.5	1.1
Forced vital capacity (FVC), Best measure	0.4	1.4	2.6	-1.6	0.5
Emphysema/chronic bronchitis	0.4	0.4	0.7	0.3	-0.8
Illnesses of siblings: Diabetes	0.4	0.5	1.0	1.0	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.5	0.0	-1.2
Pain experienced in last month	0.4	0.7	1.4	0.2	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-1.0	-0.0
Crohns Disease (2017)	0.3	0.6	1.1	-1.0	-0.4
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.0	-0.8
Blood Red Count	0.3	2.7	2.8	1.7	-1.6
Hypothyroidism (self reported)	0.3	0.8	1.6	-0.1	1.2
Neuroticism	0.3	0.7	1.2	-1.1	-0.5
Diabetes (mother)	0.3	0.3	0.4	-0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	0.5	-0.7
Medication: Simvastatin	0.3	0.5	1.0	-1.0	0.0
Father’s age at death	0.3	0.4	0.8	0.0	-0.9
Noisy workplace	0.3	0.3	0.4	-0.6	0.5
Asthma	0.3	0.6	0.7	0.8	0.8
Tense / ‘highly strung’	0.3	0.5	0.9	0.3	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.4	0.6	0.5
Birth weight	0.3	0.7	1.4	-0.1	1.2
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	1.1	0.2
Migraine (self-reported)	0.3	0.4	0.7	0.8	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.4	0.6	0.5
Chest pain or discomfort	0.3	0.5	0.6	0.6	-0.7
Hypertension (Self-reported)	0.3	0.8	1.5	0.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.8	0.2
Medication for cholesterol	0.3	0.4	0.7	0.2	-0.8
Mother’s age at death	0.3	0.4	0.6	-0.8	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.8	0.3
Risk taking	0.3	0.4	0.8	-0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.9	-0.1
Supplements: Calcium	0.3	0.4	0.7	0.2	0.8
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	0.2
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	1.0	0.3
Major Depression (MDD)	0.2	0.2	0.4	-0.2	0.6
LDL Cholesterol	0.2	0.4	0.8	0.9	-0.0
Hand grip strength (left)	0.2	0.6	1.1	-1.0	0.4
Angina	0.2	0.3	0.4	0.4	0.7
Qualifications: CSEs or equivalent	0.2	0.2	0.5	0.1	0.7
Forced vital capacity (FVC)	0.2	0.6	1.1	-1.1	0.3
Number of live births	0.2	0.3	0.5	0.4	0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.8	0.9	-0.0
Heart disease (mother)	0.2	0.2	0.3	-0.5	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.3	-0.6
Pulse rate, automated reading	0.2	0.7	0.8	-0.8	0.9
Had major operations	0.2	0.3	0.6	-0.8	0.0
Knee pain experienced in last month	0.2	0.3	0.6	0.1	0.8
Loneliness, isolation	0.2	0.2	0.4	-0.6	0.2
Asthma (self-reported)	0.2	0.5	0.7	0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.6	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.0	-0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.4	-0.3	0.7
Breast Cancer	0.1	0.2	0.2	0.5	-0.4
Fasting Glucose	0.1	0.1	0.3	-0.0	-0.5
Ulcerative Colitis	0.1	0.2	0.3	0.5	0.2
Blood Eosinophil Count	0.1	0.6	0.9	0.6	-0.9
Cardiovascular Disease	0.1	0.2	0.4	-0.4	0.6
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.6	0.2
Pack years adult smoking proportion	0.1	0.2	0.3	0.4	0.5
Hand grip strength (right)	0.1	0.3	0.5	-0.7	0.4
High blood pressure	0.1	0.4	0.7	0.3	-0.9
Alcohol usually taken with meals	0.1	0.1	0.3	0.2	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	-0.5	0.3
Illnesses of mother	0.1	0.1	0.2	-0.4	-0.1
Blood clot in the leg (DVT)	0.1	0.2	0.2	-0.3	0.5
Medication: Amlodipine	0.1	0.2	0.3	0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.6	0.1
Number of full brothers	0.1	0.1	0.1	-0.3	-0.3
Angina (self-reported)	0.1	0.2	0.2	0.3	0.5
Overall health rating	0.1	0.3	0.4	0.4	0.6
Leg pain on walking	0.1	0.1	0.1	0.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.5	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	-0.2
Medication: Lisinopril	0.1	0.1	0.2	0.0	-0.4
Diastolic blood pressure, automated reading	0.1	0.4	0.8	0.9	0.2
Pack years of smoking	0.1	0.1	0.2	0.4	0.2
Ovarian Cancer	0.0	0.0	0.0	-0.1	-0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.1	0.1	0.1	-0.3
Rheumatoid Arthritis	0.0	0.0	0.0	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.2	0.3
Tanning	0.0	0.1	0.1	-0.2	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.0	-0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	-0.2
Happiness	0.0	0.0	0.0	0.1	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	0.0	0.3
Lung cancer (father)	0.0	0.0	0.1	0.3	-0.0
Medication: Blood pressure	0.0	0.1	0.2	-0.1	0.4
Mood swings	0.0	0.0	0.1	-0.0	-0.3
Financial situation satisfaction	0.0	0.0	0.0	-0.1	-0.2

Hub : Genes

FOXO3

Models

Trait associations