Hub : Genes

ZUFSP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.2438 0.0762 0.00048 0.034 NA 0.100 NA 0.091 0.0220 NA 0.00020 NA 0.00037
2 TCGA Breast Invasive Carcinoma 0.0309 0.0169 0.00021 0.005 0.013 0.016 NA 0.011 0.0270 0.00081 0.00025 NA 0.00160
3 TCGA Colon Adenocarcinoma 0.0490 0.0380 0.00980 0.040 0.028 0.026 NA 0.037 0.0024 0.00970 0.01200 NA 0.00330
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0256 0.0164 0.00240 0.014 0.025 0.020 NA 0.016 0.0088 0.00068 0.00240 NA 0.00550
5 TCGA Brain Lower Grade Glioma 0.1110 0.0590 0.00078 0.023 0.022 0.018 NA 0.010 0.0011 0.00130 0.00310 NA 0.02300
6 TCGA Prostate Adenocarcinoma 0.0274 0.0177 0.00620 0.005 0.016 0.016 NA 0.009 0.0870 0.00780 0.00680 NA 0.03400

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.3 0.5 0.7 -0.3 -0.5 -0.6 0.6 -0.3
Bipolar Disorder or Schizophrenia 1.3 3.1 5.5 0.7 2.0 1.0 1.6 2.3 2.1
Depressed Affect (Nagel 2018) 0.1 0.3 0.6 -0.4 -0.4 -0.4 -0.7 -0.2 -0.8
Depression (Nagel 2018) 0.2 0.2 0.5 -0.6 -0.2 0.1 -0.4 -0.7 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.8 3.2 0.2 -0.5 -1.8 -0.9 -0.5 -0.6
Neuroticism (Nagel 2018) 0.2 0.5 1.4 -0.7 -0.2 -0.3 -1.2 -0.5 -1.0
Schizophrenia (2018) 2.6 5.4 8.9 0.3 2.9 1.6 2.5 2.5 3.0
Schizophrenia vs Biploar Disorder 2.1 2.8 5.0 -0.5 2.0 0.7 1.8 1.9 2.2
Worry (Nagel 2018) 0.2 0.4 1.0 -0.4 0.5 -0.7 -1.0 -0.4 -0.3
Alzheimer’s Disease (in mother) 0.9 1.0 3.0 -0.2 -1.5 0.3 -0.2 -1.7 -0.9
Alzheimer’s Disease (in father) 0.2 0.3 1.1 -0.1 0.0 0.2 0.5 -1.1 0.4
Alzheimer’s Disease (including proxy) 0.4 0.6 2.5 -0.4 -0.6 0.7 0.6 -1.6 0.1
Crohns Disease (2017) 1.3 2.9 7.1 -2.4 1.2 2.7 1.4 0.2 1.1
Irritable Bowel Disease (IBD) 1.1 2.5 10.6 -0.9 0.2 3.3 1.7 -0.8 0.3
Ulcerative Colitis (UC) 1.1 2.0 6.7 0.7 -0.4 2.6 1.9 -0.9 -0.2
Major Depression (MDD) 1.6 2.0 3.6 -0.9 -0.6 -1.9 -1.9 -1.4 -1.2
Reaction Time 2.0 3.8 6.0 -2.3 -1.0 -2.1 -2.5 -1.5 -1.9
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.2 0.3 -0.0 -1.5 0.5 -0.1 0.5
Breast Cancer 0.4 0.9 3.8 -0.1 0.4 2.0 1.1 -0.3 0.5
Ovarian Cancer 0.7 1.0 2.1 0.3 1.4 -0.7 0.3 1.4 1.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 1.0 -0.4 -0.2 -0.5 -0.6 -1.0 -0.2
Bipolar Disorder (2011) 3.0 2.9 4.4 -0.8 -2.1 -1.4 -2.0 -1.3 -2.1
Body Mass Index (BMI) (2010) 2.2 3.0 5.4 -0.4 -2.0 -2.3 -2.3 0.3 -1.9
Coronary Artery Disease (CAD) 0.6 0.7 2.1 1.4 -0.3 -1.2 -0.5 -0.5 0.1
Crohns Disease (2012) 0.8 1.3 3.7 -1.9 0.0 1.7 1.0 0.1 0.1
Mean Putamen Volume 0.3 0.3 1.0 -0.4 0.4 0.3 -0.5 -1.0 -0.2
Fasting Glucose 0.9 1.0 2.1 0.2 -1.2 -0.9 -0.6 -1.4 -1.2
HbA1C 0.7 0.8 2.9 -0.3 -0.7 -1.7 -0.7 -0.7 -0.5
HDL Cholesterol 0.1 0.2 0.7 0.4 -0.3 0.8 -0.0 -0.2 -0.2
LDL Cholesterol 1.0 1.6 2.8 0.2 -1.7 -0.8 -1.0 -1.6 -1.6
Lupus 0.8 1.2 4.5 -0.5 0.8 2.1 1.1 -0.1 0.6
Neuroticism (2016) 0.3 0.5 1.5 1.2 0.6 -0.8 -0.2 0.1 0.4
Primary Biliary Cirrhosis 2.0 2.8 5.5 0.8 1.9 0.1 1.7 2.3 2.0
Rheumatoid Arthritis 0.2 0.3 0.8 0.7 -0.3 -0.7 -0.5 0.9 -0.0
Schizophrenia (2014) 2.2 4.8 7.8 0.8 2.4 1.1 2.4 2.8 2.7
Triglycerides 1.4 2.3 5.1 -0.1 -1.6 -1.7 -2.2 -0.7 -1.7
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.0 0.2 -1.4 -1.4 -1.0 0.0 -0.6
Ulcerative Colitis 1.5 2.1 6.3 -0.7 -1.2 1.8 0.7 -2.5 -1.0
Blood Eosinophil Count 0.8 6.1 22.5 -4.7 -0.0 -2.8 -1.0 2.2 0.7
Blood Platelet Count 0.4 4.6 17.6 4.2 -1.7 -0.9 0.5 2.4 -0.3
Blood Red Count 0.3 3.1 6.8 -2.6 -1.7 -0.9 -1.3 -2.1 -1.4
Blood White Count 0.5 3.9 11.9 3.5 0.7 -1.8 0.2 2.5 1.3
Heel T-Score 0.0 0.2 0.5 0.7 0.3 0.1 0.4 -0.5 0.1
BMI 0.5 2.9 7.3 -0.2 -1.2 -2.5 -2.7 -0.5 -1.4
Height 0.3 5.3 15.1 -0.7 -1.9 2.2 2.2 -3.9 -1.7
Waist Hip Ratio (WHR) 1.4 6.1 12.6 -1.9 -2.1 -3.0 -3.5 -1.3 -2.3
Systolic Blood Pressure 0.0 0.2 0.8 -0.2 0.9 -0.3 0.1 -0.4 0.6
Smoking Status 1.7 4.1 8.1 -1.0 -2.2 -2.8 -1.8 -1.1 -2.4
Allergy or Eczema 0.2 0.6 2.5 -1.6 -0.1 -0.7 -0.7 0.5 -0.2
Cardiovascular Disease 1.2 4.1 11.5 -1.4 -0.9 -3.4 -2.8 1.2 -1.2
Hypothyroidism (self reported) 0.9 2.1 5.8 -0.9 -0.8 -1.2 -1.3 -2.4 -1.4
Respiratory disease 0.8 1.8 3.2 -1.5 1.6 -1.0 0.1 1.8 1.4
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.4 -0.5 -0.6 -1.5 -1.0 0.2 -0.7
Lung FEV1/FVC ratio 1.4 7.0 28.1 5.3 -1.4 -2.1 -1.6 -1.7 -1.4
Lung FVC 0.8 4.1 9.2 1.1 -3.0 -1.2 -1.7 -1.3 -2.8
Neuroticism 0.5 1.1 2.4 -0.7 -0.5 -1.5 -1.6 -0.3 -1.1
Chronotype (morning person) 1.1 2.6 4.1 1.5 1.8 1.4 1.8 0.9 2.0
Hair Pigment 0.0 0.3 0.8 0.1 0.1 -0.9 -0.6 0.6 0.3
Tanning 0.0 0.6 3.1 1.8 0.2 0.2 -0.2 -0.6 0.2
Hand grip strength (left) 0.3 0.7 2.3 0.6 0.2 1.2 1.5 -0.5 0.3
Number of treatments/medications taken 2.4 4.3 12.2 -1.2 -1.2 -3.5 -2.7 1.2 -1.6
Average weekly spirits intake 0.7 0.9 2.2 -0.7 -0.4 -1.5 -1.0 0.9 -0.8
Sensitivity / hurt feelings 0.6 1.0 3.2 -0.7 -0.3 -1.2 -1.8 -0.1 -0.8
Frequency of depressed mood in last 2 weeks 0.4 0.6 2.0 -1.4 -0.1 0.0 -0.2 -1.0 -0.7
Hearing difficulty/problems: Yes 0.7 1.0 1.5 -0.9 -1.2 -1.2 -1.2 0.2 -0.9
Relative age of first facial hair 0.6 1.3 2.4 0.6 1.2 0.9 1.6 1.2 1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.1 -0.4 -1.1 -0.3 -1.5 -1.0 -1.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.4 -0.4 0.7 -0.6 -0.4 0.3 0.4
Ever had hysterectomy (womb removed) 0.5 0.6 2.2 0.4 -0.1 -1.5 -0.8 0.8 -0.2
Systolic blood pressure, automated reading 0.2 0.6 3.1 0.2 -0.1 -1.8 -0.6 -0.6 -0.1
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.3 0.3 -1.4 -0.5 -1.5 -1.0 -1.3
Angina 0.2 0.3 1.3 -0.3 0.1 -1.1 -0.7 0.2 0.1
Medication for hormone replacement therapy 1.8 2.0 3.0 -0.9 1.7 1.6 1.6 0.6 1.7
Vitamin and mineral supplements 0.8 1.1 3.2 0.1 -1.5 -0.3 -0.2 -1.1 -1.8
Supplements: Zinc 1.0 1.1 1.8 -0.1 1.2 1.4 0.6 1.2 1.3
Medication: Co-codamol 0.5 0.6 1.7 0.8 0.3 1.3 0.8 0.3 0.4
Medication: Metformin 1.5 2.1 4.4 -2.1 -1.3 -1.6 -1.3 -0.4 -1.4
Diabetes (father) 0.2 0.3 0.9 0.1 -0.5 0.9 -0.0 -0.6 -0.5
Diabetes (mother) 0.5 0.6 1.8 1.1 -0.4 -1.3 -0.5 0.4 -0.1
Severe depression (siblings) 0.9 1.1 2.0 -1.1 -1.1 -1.4 -1.1 0.6 -0.4
Pack years adult smoking proportion 0.3 0.4 0.7 0.7 0.7 0.3 0.9 0.1 0.8
Impedance of leg (right) 0.1 0.5 1.4 -0.5 -0.5 1.2 1.1 -0.1 0.2
Leg fat-free mass (left) 0.1 0.3 1.1 0.2 -0.3 -0.4 0.1 -1.1 -0.6
Trunk fat percentage 0.2 0.8 1.8 -1.2 -1.3 -0.8 -0.1 -0.1 -0.9
Hand grip strength (right) 0.3 0.8 2.4 1.6 -0.2 0.7 1.4 0.0 0.3
Townsend deprivation index at recruitment 0.4 0.6 1.5 0.4 -0.7 -1.0 -0.6 0.1 -1.2
Current tobacco smoking 0.9 1.5 3.3 -0.6 -1.7 -1.8 -0.5 -0.4 -1.4
Average weekly fortified wine intake 0.2 0.2 1.0 -1.0 0.0 0.5 -0.2 -0.3 -0.3
Maternal smoking around birth 0.5 0.7 3.0 0.0 -0.6 1.7 1.0 -0.2 -0.3
Fed-up feelings 0.6 1.1 2.9 0.9 0.4 1.0 1.7 1.1 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.2 1.5 0.8 1.0 0.5 0.1 0.7
Relative age voice broke 0.2 0.3 0.7 -0.8 0.7 0.3 0.5 0.4 0.5
Taking other prescription medications 1.9 3.0 5.7 -2.4 -1.2 -2.0 -1.6 -0.8 -1.8
Age when periods started (menarche) 0.4 1.1 1.6 0.4 -1.3 1.1 -0.9 -1.1 -1.1
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 1.9 0.8 0.8 -0.4 0.4 1.4 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 3.7 0.1 1.9 0.4 1.0 -0.1 1.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.5 -0.5 -0.9 1.2 0.2 -1.2 -0.7
Qualifications: CSEs or equivalent 0.2 0.2 0.4 -0.6 -0.6 0.6 0.5 -0.3 -0.1
Serious illness, injury or assault to yourself 1.1 1.3 2.2 0.2 -1.5 -1.0 -1.5 -0.8 -1.5
High blood pressure 0.6 1.7 5.4 -0.7 -0.4 -2.3 -1.2 1.5 -0.2
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 -1.0 0.2 -0.6 -0.9 0.7 0.0
Multivitamins +/- minerals 1.4 1.8 4.1 -0.5 1.8 1.0 0.6 1.4 2.0
Stomach or abdominal pain in last month 1.3 1.6 4.8 -1.2 -2.2 0.2 -0.2 -0.9 -1.6
Supplements: Glucosamine 0.3 0.4 1.5 1.2 0.4 0.8 -0.0 -0.2 0.0
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 5.4 2.3 0.2 -0.2 0.3 0.6 0.6
Medication: Atenolol 1.1 1.4 4.8 -0.9 -0.6 -2.2 -1.2 1.0 -0.3
Medication: Levothyroxine sodium 0.6 1.0 1.8 -0.4 -0.8 -1.0 -1.1 -1.4 -1.1
Sitting height 0.5 3.6 7.8 1.9 -0.5 1.8 2.6 -2.8 -0.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 0.6 0.5 -0.7 -0.9 -0.3 0.3
High blood pressure (mother) 0.1 0.1 0.5 -0.0 0.7 0.1 0.1 0.2 0.4
Body mass index (BMI) 0.4 1.6 4.5 -0.6 -0.8 -2.1 -1.6 -0.0 -1.1
Impedance of leg (left) 0.1 0.6 1.3 -1.0 -1.1 0.9 0.6 -0.2 -0.3
Leg predicted mass (left) 0.1 0.3 1.1 0.2 -0.2 -0.3 0.1 -1.1 -0.6
Trunk fat mass 0.3 1.1 2.1 -1.1 -1.5 -1.1 -0.4 -0.7 -1.2
Waist circumference 0.8 3.0 6.2 -1.4 -1.6 -2.5 -2.0 -0.8 -1.7
Number of incorrect matches in round 0.4 0.7 2.5 1.6 -0.4 0.2 -1.0 -0.5 -0.5
Past tobacco smoking 2.2 4.1 7.5 1.1 2.0 2.7 2.4 1.2 2.2
Alcohol usually taken with meals 0.2 0.2 1.0 1.0 0.1 -0.1 -0.6 0.2 0.0
Nervous feelings 0.4 0.8 1.9 -0.3 0.4 -1.4 -1.0 1.2 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.9 0.3 -0.7 -0.9 -1.4 -0.4 -1.0
Hearing difficulty/problems with background noise 2.2 3.5 5.8 -1.2 -1.9 -1.0 -2.4 -1.9 -2.4
Hair/balding pattern: Pattern 2 0.5 0.6 1.9 -0.4 1.4 0.9 0.4 0.7 0.7
Had menopause 0.6 0.7 2.1 0.1 -0.7 -1.5 -0.8 0.5 -0.9
Had other major operations 0.4 0.5 1.9 -1.4 -0.7 -0.3 -0.3 -0.1 -0.8
Forced vital capacity (FVC) 0.4 1.5 4.5 2.1 -1.4 0.7 0.5 -0.8 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 2.9 -0.4 1.7 0.1 0.7 -0.1 1.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.9 0.5 1.0 -0.1 0.3 0.8 0.8
Qualifications: None of the above 0.1 0.3 0.8 0.9 0.1 -0.8 0.2 0.3 -0.1
Financial difficulties in last 2 years 0.1 0.1 0.4 -0.6 0.2 -0.4 0.2 -0.0 -0.3
Mouth/teeth dental problems 1.0 1.6 7.7 0.7 0.5 2.8 0.9 -0.3 0.3
Heart attack 0.8 1.1 3.6 -0.7 -0.5 -1.9 -0.6 1.3 0.1
Allergy 0.6 1.4 3.3 1.4 0.2 1.8 1.6 -0.5 0.5
Pain all over the body in last month 0.7 0.8 1.4 -0.6 1.2 -1.1 -0.1 1.2 0.3
Diabetes (self-reported) 0.3 0.4 1.2 -0.7 0.4 -0.6 0.4 1.1 0.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.1 -1.1 -0.4 -1.0 -1.0 -0.4 -0.7
Medication: Ramipril 0.2 0.2 0.8 -0.0 0.4 -0.2 0.6 0.9 0.3
Medication: Simvastatin 1.0 1.5 4.6 -1.3 -0.7 -2.1 -1.3 -0.3 -0.8
Fluid intelligence score 0.5 1.1 1.9 1.2 1.1 -0.3 1.0 0.8 1.4
Illnesses of siblings 0.4 0.5 1.1 -1.0 -0.1 1.1 1.0 -0.4 -0.0
Neuroticism score 0.1 0.2 0.6 0.1 0.3 -0.8 -0.2 0.4 -0.3
Weight 0.2 1.2 2.0 -0.8 -1.2 -1.4 -0.7 -1.0 -1.3
Impedance of arm (right) 0.4 1.8 5.3 -0.5 0.1 2.3 2.2 -0.1 0.7
Arm fat percentage (right) 0.4 1.5 2.5 -1.3 -1.2 -1.6 -1.2 -0.4 -1.3
Trunk fat-free mass 0.2 1.3 3.5 0.3 -0.7 -1.1 -0.7 -1.9 -1.4
Hip circumference 0.3 1.2 3.8 -0.4 -1.1 -2.0 -0.9 -0.4 -1.0
Time employed in main current job 0.7 0.9 1.7 1.3 0.7 0.2 1.1 0.7 1.1
Alcohol intake versus 10 years previously 1.0 1.4 3.7 -0.3 1.1 0.4 1.5 1.9 1.1
Father’s age at death 0.3 0.4 0.6 -0.5 0.7 0.7 0.5 -0.7 0.3
Worrier / anxious feelings 0.4 0.7 3.2 -0.2 1.8 -0.1 0.1 0.6 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.0 0.2 0.2 -1.0 -0.5 0.6 0.2
Falls in the last year 0.4 0.6 1.5 -1.2 0.3 -1.0 -0.8 0.6 0.2
Hair/balding pattern: Pattern 3 0.5 0.8 1.4 -0.3 -0.8 -1.2 -1.1 -0.3 -1.2
Number of live births 1.2 1.7 2.8 -0.9 -1.0 -1.6 -1.7 -1.0 -1.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 9.2 3.0 -1.3 0.5 0.2 -1.1 -1.2
Pulse rate 0.2 0.3 1.2 0.2 0.8 1.1 -0.0 0.1 -0.1
Happiness 1.5 1.8 3.2 1.3 1.2 1.0 1.8 1.1 1.6
Noisy workplace 0.3 0.4 0.8 0.4 -0.8 -0.9 0.5 0.6 -0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.2 1.5 0.3 1.5 1.2 0.6 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.1 -0.9 -1.0 -0.9 -0.6 -0.5 -0.9
Mouth/teeth dental problems: Dentures 1.1 1.9 9.6 0.2 -0.9 -3.1 -0.8 0.5 -0.4
Asthma 0.9 1.7 3.3 -1.8 0.8 -1.8 -0.1 1.6 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 5.9 2.4 0.4 1.3 -0.1 0.0 -0.1
Medication: Cholesterol lowering 1.0 1.6 4.4 -1.6 -1.0 -2.1 -0.9 0.0 -1.0
Depression (self-reported) 1.1 1.4 2.7 -0.6 -0.3 -1.5 -1.4 -1.6 -0.9
Medication: Lansoprazole 1.0 1.2 4.5 -0.7 -0.3 -2.1 -1.2 -0.3 -0.6
Prospective memory result 1.1 1.4 3.3 -1.3 -0.1 -1.8 0.1 1.8 0.2
Lung cancer (father) 1.3 1.5 2.5 -1.6 -1.2 -1.2 -1.3 -0.7 -1.2
Illnesses of mother 0.6 0.7 2.1 -0.3 0.6 1.5 1.0 0.3 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 5.4 2.3 -1.9 0.2 -0.1 -1.4 -1.9
Pulse wave Arterial Stiffness index 0.5 0.6 1.9 0.0 0.4 -0.2 0.9 1.4 0.8
Impedance of arm (left) 0.5 2.3 6.5 -0.2 0.3 2.5 2.5 0.3 1.1
Arm fat mass (right) 0.4 1.7 3.5 -0.8 -1.4 -1.9 -1.2 -0.8 -1.5
Trunk predicted mass 0.2 1.2 3.3 0.2 -0.7 -1.1 -0.7 -1.8 -1.4
Standing height 0.2 2.3 6.0 -0.3 -1.1 1.4 1.9 -2.4 -0.9
Length of working week for main job 0.5 0.5 1.1 0.1 -0.9 0.0 -0.3 -1.1 -1.0
Exposure to tobacco smoke at home 1.4 1.5 4.5 -1.0 -1.1 -2.1 -1.1 -0.4 -1.1
Breastfed as a baby 1.2 1.5 3.3 0.9 1.8 1.2 0.5 0.8 1.7
Tense / ‘highly strung’ 0.3 0.4 1.4 0.2 0.1 -0.4 -0.5 -1.2 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.5 0.9 1.2 -0.7 -0.1 0.4 0.6
Hair/balding pattern: Pattern 4 0.3 0.7 3.6 -1.9 0.2 0.1 -0.2 0.6 0.3
Birth weight of first child 1.8 3.3 8.8 0.8 -1.9 1.4 -0.2 -3.0 -2.1
Peak expiratory flow (PEF) 0.5 1.1 4.0 2.0 -1.1 -0.8 -0.3 0.1 -0.8
Pulse wave reflection index 0.5 0.6 1.7 -0.6 0.3 -0.5 0.3 1.3 1.2
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.6 0.0 1.5 -0.0 1.3 1.6 1.5
Loud music exposure frequency 0.2 0.3 0.8 0.4 -0.2 0.7 0.9 0.2 0.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.4 0.2 -0.3 1.6 0.7 -0.1 -0.3
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.4 -0.8 -1.0 -1.8 -1.5 -0.4 -0.8
Blood clot in the leg (DVT) 0.2 0.3 0.8 -0.3 0.1 -0.9 -0.9 0.1 -0.3
Medication: Paracetamol 2.0 3.3 5.2 -0.0 -2.1 -1.9 -2.3 -1.2 -2.2
Headache pain in last month 0.8 1.3 5.4 2.3 0.8 -0.4 -0.2 1.3 0.3
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 9.5 1.9 1.2 3.1 1.9 -0.3 1.1
Glaucoma (self-reported) 0.5 0.6 3.0 -0.2 0.2 -1.7 -0.1 0.7 0.2
Gout (self-reported) 0.3 0.4 1.8 -0.2 -0.2 0.4 0.1 -1.3 -0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.4 0.4 -0.4 -0.6 -1.0 -1.6 -0.9
Medication: Amlodipine 1.4 2.0 5.8 0.5 -1.1 -2.4 -1.8 0.5 -1.0
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.0 -1.4 0.1 -2.0 -1.2 0.8 0.3
Birth weight 0.9 1.9 4.6 1.2 -1.1 1.1 0.2 -2.1 -1.6
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 -0.6 -0.4 -0.1 -0.5 -0.1 -0.8
High blood pressure (siblings) 1.1 1.5 2.4 0.9 -1.6 -0.8 -1.3 -1.1 -1.5
Forced vital capacity (FVC), Best measure 0.6 2.2 5.2 1.1 -2.3 0.3 -0.1 -1.6 -2.1
Body fat percentage 0.3 1.1 2.1 -1.4 -1.3 -1.2 -0.6 -0.0 -1.0
Leg fat percentage (right) 0.3 1.3 3.3 -1.0 -1.0 -1.8 -1.1 0.1 -1.0
Arm fat-free mass (right) 0.2 1.0 1.4 0.3 -0.9 -1.2 -0.9 -1.2 -1.2
Exposure to tobacco smoke outside home 0.3 0.4 1.3 0.3 1.1 0.5 0.8 0.1 0.6
Comparative body size at age 10 0.5 1.4 5.3 -0.4 -0.8 -1.0 -2.3 -0.4 -1.0
Number of full brothers 1.0 1.3 2.8 0.8 -0.6 -1.1 -1.4 -1.7 -0.9
Worry too long after embarrassment 0.3 0.5 1.1 -0.3 -0.1 -0.7 -1.1 -0.6 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.2 0.9 1.8 0.6 1.1 -0.1 1.5
Wheeze or whistling in the chest in last year 1.3 2.3 6.2 -0.6 2.5 -1.0 0.6 1.8 1.7
Number of children fathered 0.8 0.9 1.7 -0.6 -1.3 -1.1 -1.1 -0.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.8 0.5 -0.4 1.3 0.4 0.8 0.1
Age at first live birth 0.5 0.8 2.1 0.1 0.2 1.4 1.4 0.5 0.8
Pulse wave peak to peak time 0.6 0.7 2.8 -0.1 -0.5 0.4 -0.7 -1.7 -0.8
Health satisfaction 0.2 0.2 1.1 1.1 0.3 -0.2 -0.4 0.1 0.0
Shortness of breath walking on level ground 1.4 1.6 5.6 -1.1 -0.5 -2.4 -1.1 1.1 -0.6
Qualifications: College or University degree 0.0 0.1 0.2 0.3 -0.1 0.5 -0.1 0.3 0.5
Eye problems/disorders: None of the above 0.9 1.0 2.6 1.3 -0.1 1.6 0.5 -1.2 -0.3
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.7 -2.2 -1.8 -0.2 -0.5 -1.0 -1.4
Emphysema/chronic bronchitis 0.5 0.6 1.4 -1.2 0.7 -0.2 -0.8 0.9 0.6
Medication for pain relief, constipation, heartburn 0.5 0.9 2.1 -1.3 0.8 1.4 0.9 -0.2 0.7
Neck or shoulder pain in last month 0.4 0.6 1.4 0.5 -0.9 0.7 -0.7 0.1 -1.2
Medication: Blood pressure 2.5 4.3 11.6 -1.8 -1.8 -3.4 -2.4 -0.1 -1.5
Angina (self-reported) 0.2 0.3 1.1 -0.4 -0.1 -1.1 -0.8 0.1 -0.0
Migraine (self-reported) 0.8 1.0 2.4 1.5 0.7 -0.5 -0.4 1.5 0.8
Medication: Ibuprofen 1.2 1.4 5.7 2.4 -0.0 1.4 -0.5 -0.5 -0.7
Medication: Allopurinol 0.1 0.1 0.8 0.9 -0.0 0.1 0.1 0.2 -0.2
Medication: Omeprazole 1.6 1.9 3.9 -0.9 -1.8 -0.4 -0.9 -2.0 -1.6
Medication: Seretide 50 evohaler 0.6 0.7 2.1 -1.0 0.0 -0.9 -0.3 1.4 -0.1
Mean time to correctly identify matches 2.3 4.3 6.9 -2.5 -1.1 -2.2 -2.6 -1.8 -1.8
Heart disease (mother) 0.6 0.7 2.5 0.5 -0.0 -1.6 -0.4 1.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 -0.4 0.6 0.0 0.5 0.1 0.3
Whole body fat mass 0.4 1.5 2.2 -1.5 -1.4 -1.4 -0.7 -0.7 -1.3
Leg fat mass (right) 0.4 1.4 2.8 -1.0 -1.3 -1.7 -1.0 -0.5 -1.2
Arm predicted mass (right) 0.2 1.1 1.8 0.5 -1.0 -1.4 -0.9 -1.2 -1.3
Pulse rate, automated reading 0.5 1.5 6.1 -0.2 1.1 2.5 0.9 -0.7 0.7
Alcohol intake frequency. 0.4 0.9 1.7 -1.0 0.4 -1.3 -1.3 0.9 -0.4
Comparative height size at age 10 0.4 2.0 6.4 -0.9 -1.6 0.7 0.5 -2.5 -1.3
Number of full sisters 1.4 1.7 4.0 0.7 2.0 1.2 0.9 0.6 1.7
Suffer from ‘nerves’ 0.6 1.0 3.2 0.6 0.7 -0.8 0.4 1.8 1.0
Overall health rating 0.8 1.7 2.8 -1.7 -0.8 0.1 -1.1 -1.6 -1.6
Chest pain or discomfort 0.6 0.8 2.2 0.0 1.5 -0.1 0.4 1.2 1.0
Had major operations 0.5 0.5 1.0 -1.0 0.4 0.8 0.9 -0.8 -0.1
Age at last live birth 0.5 0.7 2.7 -1.6 -0.5 0.8 0.4 -0.8 -0.2
Family relationship satisfaction 1.2 1.5 3.1 0.7 1.3 0.7 1.3 1.2 1.8
Leg pain on walking 1.1 1.3 2.7 -0.3 -1.1 -1.6 -1.5 -0.7 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 3.8 -2.0 -1.5 -0.4 -0.6 -1.8 -1.5
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.3 -0.3 -0.4 1.1 0.4 -1.0 -0.6
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.3 0.4 1.1 0.5 0.4 0.9 1.2
Medication: Aspirin 1.1 1.4 4.3 -0.1 0.6 -1.4 0.6 2.1 1.2
Supplements: Vitamin C 0.6 0.7 1.2 0.3 1.1 0.9 0.7 0.7 1.1
Knee pain experienced in last month 0.7 1.1 2.9 -0.8 -1.7 0.1 -0.6 -0.6 -1.6
Hypertension (Self-reported) 0.8 2.2 7.1 -0.5 -0.8 -2.7 -1.6 1.4 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.7 -1.1 -1.2 -0.2 -0.4 -1.3 -1.0
Illnesses of father: Heart disease 0.1 0.2 0.6 -0.1 0.3 -0.8 -0.4 0.2 -0.1
Illnesses of siblings: Diabetes 0.6 0.8 3.6 0.1 0.2 -1.9 -0.9 -0.3 0.0
Smoking status: Previous 0.8 1.2 2.4 -0.5 -1.1 -1.2 -1.6 -0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.2 8.6 -0.6 0.3 2.9 2.0 -0.6 0.2
Whole body fat-free mass 0.2 1.0 2.5 0.2 -0.7 -1.0 -0.6 -1.6 -1.2
Leg fat-free mass (right) 0.1 0.5 1.5 -0.1 -0.6 -0.5 -0.2 -1.2 -0.9
Arm fat percentage (left) 0.2 0.8 1.5 -0.9 -0.9 -1.2 -0.8 -0.1 -0.9
Average weekly red wine intake 0.6 0.9 2.9 -0.5 -0.5 -0.5 -1.7 -0.7 -1.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 0.0 0.2 -0.9 -0.4 0.4 -0.2
Mood swings 0.7 1.3 1.9 1.4 1.3 0.9 1.4 0.7 1.2
Loneliness, isolation 0.4 0.5 1.3 0.5 1.1 -0.5 0.4 1.1 0.5
Long-standing illness, disability or infirmity 1.6 2.4 6.0 -1.1 -1.1 -1.8 -2.4 -0.3 -1.6
Ever had bowel cancer screening 0.1 0.2 0.8 -0.9 0.1 0.0 -0.1 -0.4 -0.1
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.3 0.1 -0.7 0.1 0.7 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 0.4 0.0 -0.9 0.2 -0.3 -0.2
Friendships satisfaction 1.2 1.4 3.5 0.5 1.8 0.2 1.1 0.8 1.9
Qualifications: nursing, teaching 0.4 0.6 2.7 -0.4 -0.5 -0.6 -1.6 0.1 -0.5
Commuting to job workplace: Walk 0.2 0.2 0.8 -0.5 0.9 -0.3 -0.2 0.3 0.5
Eye problems/disorders: Cataract 1.1 1.3 3.6 -1.4 -0.8 -1.9 -0.5 1.0 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.1 -1.8 0.4 0.7 -0.3 -1.7 -0.3
Medication for cholesterol 1.2 1.8 5.3 0.3 -1.0 1.7 0.7 -2.3 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.3 -0.3 -1.1 -0.8 -0.2 0.1 -0.8
Back pain experienced in last month 0.4 0.5 0.9 -0.3 -0.9 -0.4 -0.6 0.9 -1.0
Mineral and other dietary supplements 0.2 0.3 0.8 0.1 -0.7 -0.9 0.3 0.3 -0.6
Breast cancer (self-reported) 0.4 0.5 1.7 0.4 -1.3 -0.5 -0.4 -0.4 -0.8
Asthma (self-reported) 1.0 2.0 3.7 -1.9 1.0 -1.8 -0.1 1.9 0.9
Osteoporosis (self-reported) 0.8 1.0 1.6 -1.1 -1.3 -0.8 -0.4 -1.1 -0.9
Osteoarthritis (self-reported) 0.6 0.8 2.1 1.5 -0.5 -1.0 -0.4 0.1 -1.0
Medication: Aspirin 1.0 1.3 4.0 -0.0 0.1 -1.9 -0.0 2.0 0.7
Medication: Gliclazide 2.8 3.2 5.3 -1.7 -2.2 -0.8 -1.8 -1.4 -2.3
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 -0.7 0.3 1.1 1.0 0.3 0.3
Smoking status: Current 1.2 1.9 4.5 -0.5 -1.8 -2.1 -0.8 -0.6 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 3.6 1.9 -1.3 -1.6 -1.1 -0.0 -1.1
Whole body water mass 0.2 1.0 2.7 0.1 -0.8 -0.9 -0.5 -1.6 -1.3
Leg predicted mass (right) 0.1 0.5 1.5 -0.1 -0.6 -0.5 -0.3 -1.2 -1.0
Arm fat mass (left) 0.3 1.2 2.2 -0.5 -1.2 -1.5 -1.0 -0.8 -1.3
Number of self-reported non-cancer illnesses 1.5 2.6 9.0 -0.7 -0.6 -3.0 -1.9 0.8 -1.1
Average weekly champagne plus white wine intake 0.1 0.2 0.5 -0.3 0.2 0.7 -0.6 -0.4 -0.3
Miserableness 0.2 0.4 1.1 -1.1 -0.5 -0.0 0.0 -0.5 -0.8
Guilty feelings 1.0 1.5 3.3 1.4 -1.3 -1.1 -1.0 -0.1 -1.8
Wears glasses or contact lenses 1.3 1.5 3.9 -0.4 -1.2 -1.2 -0.9 -2.0 -1.2
Ever taken oral contraceptive pill 0.8 0.9 2.7 1.0 0.4 0.5 1.0 1.6 0.8
Hearing aid user 0.2 0.2 0.6 -0.1 0.4 0.5 0.6 0.1 0.8
Mother’s age at death 2.0 2.5 4.1 1.7 2.0 0.4 1.0 1.6 2.0
Financial situation satisfaction 1.5 1.9 3.2 0.6 1.4 0.9 1.8 1.7 1.4
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 0.9 -0.7 -0.0 -0.4 0.5 -0.5
Commuting to job workplace: Public transport 0.5 0.6 1.7 1.3 0.5 -0.2 0.1 1.2 0.4
Eye problems/disorders: Glaucoma 1.0 1.2 2.8 0.6 1.1 -1.0 0.7 1.7 1.1
Medication: Blood pressure 1.2 2.2 5.5 0.1 -1.1 -2.3 -1.9 1.4 -1.0
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.6 1.6 0.7 0.4 0.5 1.2 0.7
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.1 -0.1 0.8 1.5 0.1 -0.6 0.9
High cholesterol (Self-reported) 1.9 3.4 6.2 -1.1 -1.6 -2.5 -2.2 -1.1 -2.1
Medication: Bendroflumethiazide 0.5 0.8 1.5 -0.4 -0.0 -1.2 -1.2 1.2 0.5
Medication: Paracetamol 2.4 3.8 6.6 -0.1 -2.5 -1.4 -2.5 -1.4 -2.6
Medication: Lisinopril 0.5 0.7 1.8 0.6 0.2 -1.3 -1.0 0.9 0.2
Medication: Atorvastatin 1.0 1.2 3.6 0.1 0.5 -1.6 0.3 1.9 0.9
Illnesses of father: High blood pressure 2.0 2.5 3.8 -1.7 -1.3 -1.7 -1.9 -0.6 -1.7
Alcohol drinker status: Never 0.5 0.6 2.0 -1.4 0.0 -0.3 -0.9 -0.6 -0.8
Ever smoked 1.2 2.2 5.3 -0.6 -1.1 -2.3 -1.8 -0.9 -1.4
Basal metabolic rate 0.2 1.0 2.4 -0.0 -0.8 -0.9 -0.5 -1.6 -1.3
Leg fat percentage (left) 0.4 1.3 3.4 -1.1 -1.1 -1.9 -1.1 0.2 -1.0
Arm fat-free mass (left) 0.3 1.3 2.4 0.1 -1.0 -1.6 -0.9 -1.2 -1.4
Number of operations (self-reported) 1.3 2.0 3.4 -1.5 -1.3 -1.8 -1.2 -0.5 -1.6
Average weekly beer plus cider intake 0.7 1.0 2.9 -1.7 -1.0 0.2 0.0 -1.0 -0.9
Irritability 0.9 1.5 3.0 1.7 0.7 1.3 1.7 0.3 0.8
Risk taking 1.3 1.9 4.8 1.7 -0.3 2.2 0.9 -1.7 -0.3
Ever had prostate specific antigen (PSA) test 2.3 2.7 5.0 1.5 -2.2 0.0 -1.1 -1.9 -1.9
Fractured/broken bones in last 5 years 1.0 1.2 2.9 1.7 -1.3 -0.5 0.4 -1.2 -0.9
Age started oral contraceptive pill 1.6 2.0 4.7 -0.2 -1.3 -2.2 -2.0 -0.9 -1.0
Diastolic blood pressure, automated reading 0.4 1.1 5.5 -2.4 0.8 -0.5 -0.5 0.3 0.3
Ever depressed for a whole week 0.0 0.0 0.1 -0.2 -0.2 0.1 0.0 -0.3 -0.2
Unable to work because of sickness or disability 0.2 0.3 1.0 1.0 -0.1 0.6 0.4 -0.0 0.2
Commuting to job workplace: Cycle 3.5 4.3 9.1 3.0 2.4 0.4 1.2 2.1 2.2
Myopia 0.8 1.1 1.9 -1.3 -0.3 1.1 1.3 -1.4 0.3
Vascular/heart problems diagnosed by doctor 0.9 2.4 7.9 1.0 0.7 2.8 1.6 -1.6 0.5
Cholesterol lowering medication 0.7 1.1 3.3 0.6 0.8 -1.8 -0.8 1.1 0.7
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 2.2 -0.9 -1.4 -0.6 -1.0 -1.5 -1.4
Pain experienced in last month 0.5 0.8 4.0 -0.6 -0.1 -0.5 -0.0 -2.0 0.2
Supplements: Calcium 1.7 1.9 3.6 -1.9 1.3 1.5 1.3 0.2 1.3
Basal cell carcinoma (self-reported) 0.6 0.7 1.9 1.0 -0.6 -0.9 -1.4 0.1 -0.5
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.8 -0.6 -0.5 -1.9 -0.7 1.4 0.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.7 -0.6 -0.1 -1.3 -1.3 -0.1 -0.5
Heart disease (siblings) 0.8 0.9 1.8 1.1 1.0 -1.0 -0.1 0.7 1.3
Alcohol drinker status: Previous 0.4 0.4 1.1 0.9 0.4 0.1 -1.1 -0.6 -0.4
Pack years of smoking 0.6 0.8 1.4 0.7 1.1 0.3 1.2 0.5 1.2
Impedance of whole body 0.3 1.5 4.2 -0.6 -0.2 2.1 2.0 0.3 0.7
Leg fat mass (left) 0.3 1.1 2.3 -0.9 -1.2 -1.5 -0.9 -0.4 -1.1
Arm predicted mass (left) 0.4 1.9 2.9 -0.2 -1.3 -1.6 -1.2 -1.7 -1.7