Hub : Genes

ZUFSP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2438	0.0762	0.00048	0.034	NA	0.100	NA	0.091	0.0220	NA	0.00020	NA	0.00037
2	TCGA	Breast Invasive Carcinoma	0.0309	0.0169	0.00021	0.005	0.013	0.016	NA	0.011	0.0270	0.00081	0.00025	NA	0.00160
3	TCGA	Colon Adenocarcinoma	0.0490	0.0380	0.00980	0.040	0.028	0.026	NA	0.037	0.0024	0.00970	0.01200	NA	0.00330
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0256	0.0164	0.00240	0.014	0.025	0.020	NA	0.016	0.0088	0.00068	0.00240	NA	0.00550
5	TCGA	Brain Lower Grade Glioma	0.1110	0.0590	0.00078	0.023	0.022	0.018	NA	0.010	0.0011	0.00130	0.00310	NA	0.02300
6	TCGA	Prostate Adenocarcinoma	0.0274	0.0177	0.00620	0.005	0.016	0.016	NA	0.009	0.0870	0.00780	0.00680	NA	0.03400

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	-0.3	-0.5	-0.6	0.6	-0.3
Bipolar Disorder or Schizophrenia	1.3	3.1	5.5	0.7	2.0	1.0	1.6	2.3	2.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.4	-0.4	-0.4	-0.7	-0.2	-0.8
Depression (Nagel 2018)	0.2	0.2	0.5	-0.6	-0.2	0.1	-0.4	-0.7	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.2	0.2	-0.5	-1.8	-0.9	-0.5	-0.6
Neuroticism (Nagel 2018)	0.2	0.5	1.4	-0.7	-0.2	-0.3	-1.2	-0.5	-1.0
Schizophrenia (2018)	2.6	5.4	8.9	0.3	2.9	1.6	2.5	2.5	3.0
Schizophrenia vs Biploar Disorder	2.1	2.8	5.0	-0.5	2.0	0.7	1.8	1.9	2.2
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	0.5	-0.7	-1.0	-0.4	-0.3
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	-0.2	-1.5	0.3	-0.2	-1.7	-0.9
Alzheimer’s Disease (in father)	0.2	0.3	1.1	-0.1	0.0	0.2	0.5	-1.1	0.4
Alzheimer’s Disease (including proxy)	0.4	0.6	2.5	-0.4	-0.6	0.7	0.6	-1.6	0.1
Crohns Disease (2017)	1.3	2.9	7.1	-2.4	1.2	2.7	1.4	0.2	1.1
Irritable Bowel Disease (IBD)	1.1	2.5	10.6	-0.9	0.2	3.3	1.7	-0.8	0.3
Ulcerative Colitis (UC)	1.1	2.0	6.7	0.7	-0.4	2.6	1.9	-0.9	-0.2
Major Depression (MDD)	1.6	2.0	3.6	-0.9	-0.6	-1.9	-1.9	-1.4	-1.2
Reaction Time	2.0	3.8	6.0	-2.3	-1.0	-2.1	-2.5	-1.5	-1.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.2	0.3	-0.0	-1.5	0.5	-0.1	0.5
Breast Cancer	0.4	0.9	3.8	-0.1	0.4	2.0	1.1	-0.3	0.5
Ovarian Cancer	0.7	1.0	2.1	0.3	1.4	-0.7	0.3	1.4	1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	1.0	-0.4	-0.2	-0.5	-0.6	-1.0	-0.2
Bipolar Disorder (2011)	3.0	2.9	4.4	-0.8	-2.1	-1.4	-2.0	-1.3	-2.1
Body Mass Index (BMI) (2010)	2.2	3.0	5.4	-0.4	-2.0	-2.3	-2.3	0.3	-1.9
Coronary Artery Disease (CAD)	0.6	0.7	2.1	1.4	-0.3	-1.2	-0.5	-0.5	0.1
Crohns Disease (2012)	0.8	1.3	3.7	-1.9	0.0	1.7	1.0	0.1	0.1
Mean Putamen Volume	0.3	0.3	1.0	-0.4	0.4	0.3	-0.5	-1.0	-0.2
Fasting Glucose	0.9	1.0	2.1	0.2	-1.2	-0.9	-0.6	-1.4	-1.2
HbA1C	0.7	0.8	2.9	-0.3	-0.7	-1.7	-0.7	-0.7	-0.5
HDL Cholesterol	0.1	0.2	0.7	0.4	-0.3	0.8	-0.0	-0.2	-0.2
LDL Cholesterol	1.0	1.6	2.8	0.2	-1.7	-0.8	-1.0	-1.6	-1.6
Lupus	0.8	1.2	4.5	-0.5	0.8	2.1	1.1	-0.1	0.6
Neuroticism (2016)	0.3	0.5	1.5	1.2	0.6	-0.8	-0.2	0.1	0.4
Primary Biliary Cirrhosis	2.0	2.8	5.5	0.8	1.9	0.1	1.7	2.3	2.0
Rheumatoid Arthritis	0.2	0.3	0.8	0.7	-0.3	-0.7	-0.5	0.9	-0.0
Schizophrenia (2014)	2.2	4.8	7.8	0.8	2.4	1.1	2.4	2.8	2.7
Triglycerides	1.4	2.3	5.1	-0.1	-1.6	-1.7	-2.2	-0.7	-1.7
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	0.2	-1.4	-1.4	-1.0	0.0	-0.6
Ulcerative Colitis	1.5	2.1	6.3	-0.7	-1.2	1.8	0.7	-2.5	-1.0
Blood Eosinophil Count	0.8	6.1	22.5	-4.7	-0.0	-2.8	-1.0	2.2	0.7
Blood Platelet Count	0.4	4.6	17.6	4.2	-1.7	-0.9	0.5	2.4	-0.3
Blood Red Count	0.3	3.1	6.8	-2.6	-1.7	-0.9	-1.3	-2.1	-1.4
Blood White Count	0.5	3.9	11.9	3.5	0.7	-1.8	0.2	2.5	1.3
Heel T-Score	0.0	0.2	0.5	0.7	0.3	0.1	0.4	-0.5	0.1
BMI	0.5	2.9	7.3	-0.2	-1.2	-2.5	-2.7	-0.5	-1.4
Height	0.3	5.3	15.1	-0.7	-1.9	2.2	2.2	-3.9	-1.7
Waist Hip Ratio (WHR)	1.4	6.1	12.6	-1.9	-2.1	-3.0	-3.5	-1.3	-2.3
Systolic Blood Pressure	0.0	0.2	0.8	-0.2	0.9	-0.3	0.1	-0.4	0.6
Smoking Status	1.7	4.1	8.1	-1.0	-2.2	-2.8	-1.8	-1.1	-2.4
Allergy or Eczema	0.2	0.6	2.5	-1.6	-0.1	-0.7	-0.7	0.5	-0.2
Cardiovascular Disease	1.2	4.1	11.5	-1.4	-0.9	-3.4	-2.8	1.2	-1.2
Hypothyroidism (self reported)	0.9	2.1	5.8	-0.9	-0.8	-1.2	-1.3	-2.4	-1.4
Respiratory disease	0.8	1.8	3.2	-1.5	1.6	-1.0	0.1	1.8	1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	-0.5	-0.6	-1.5	-1.0	0.2	-0.7
Lung FEV1/FVC ratio	1.4	7.0	28.1	5.3	-1.4	-2.1	-1.6	-1.7	-1.4
Lung FVC	0.8	4.1	9.2	1.1	-3.0	-1.2	-1.7	-1.3	-2.8
Neuroticism	0.5	1.1	2.4	-0.7	-0.5	-1.5	-1.6	-0.3	-1.1
Chronotype (morning person)	1.1	2.6	4.1	1.5	1.8	1.4	1.8	0.9	2.0
Hair Pigment	0.0	0.3	0.8	0.1	0.1	-0.9	-0.6	0.6	0.3
Tanning	0.0	0.6	3.1	1.8	0.2	0.2	-0.2	-0.6	0.2
Hand grip strength (left)	0.3	0.7	2.3	0.6	0.2	1.2	1.5	-0.5	0.3
Number of treatments/medications taken	2.4	4.3	12.2	-1.2	-1.2	-3.5	-2.7	1.2	-1.6
Average weekly spirits intake	0.7	0.9	2.2	-0.7	-0.4	-1.5	-1.0	0.9	-0.8
Sensitivity / hurt feelings	0.6	1.0	3.2	-0.7	-0.3	-1.2	-1.8	-0.1	-0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-1.4	-0.1	0.0	-0.2	-1.0	-0.7
Hearing difficulty/problems: Yes	0.7	1.0	1.5	-0.9	-1.2	-1.2	-1.2	0.2	-0.9
Relative age of first facial hair	0.6	1.3	2.4	0.6	1.2	0.9	1.6	1.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.1	-0.4	-1.1	-0.3	-1.5	-1.0	-1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.4	0.7	-0.6	-0.4	0.3	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	0.4	-0.1	-1.5	-0.8	0.8	-0.2
Systolic blood pressure, automated reading	0.2	0.6	3.1	0.2	-0.1	-1.8	-0.6	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	0.3	-1.4	-0.5	-1.5	-1.0	-1.3
Angina	0.2	0.3	1.3	-0.3	0.1	-1.1	-0.7	0.2	0.1
Medication for hormone replacement therapy	1.8	2.0	3.0	-0.9	1.7	1.6	1.6	0.6	1.7
Vitamin and mineral supplements	0.8	1.1	3.2	0.1	-1.5	-0.3	-0.2	-1.1	-1.8
Supplements: Zinc	1.0	1.1	1.8	-0.1	1.2	1.4	0.6	1.2	1.3
Medication: Co-codamol	0.5	0.6	1.7	0.8	0.3	1.3	0.8	0.3	0.4
Medication: Metformin	1.5	2.1	4.4	-2.1	-1.3	-1.6	-1.3	-0.4	-1.4
Diabetes (father)	0.2	0.3	0.9	0.1	-0.5	0.9	-0.0	-0.6	-0.5
Diabetes (mother)	0.5	0.6	1.8	1.1	-0.4	-1.3	-0.5	0.4	-0.1
Severe depression (siblings)	0.9	1.1	2.0	-1.1	-1.1	-1.4	-1.1	0.6	-0.4
Pack years adult smoking proportion	0.3	0.4	0.7	0.7	0.7	0.3	0.9	0.1	0.8
Impedance of leg (right)	0.1	0.5	1.4	-0.5	-0.5	1.2	1.1	-0.1	0.2
Leg fat-free mass (left)	0.1	0.3	1.1	0.2	-0.3	-0.4	0.1	-1.1	-0.6
Trunk fat percentage	0.2	0.8	1.8	-1.2	-1.3	-0.8	-0.1	-0.1	-0.9
Hand grip strength (right)	0.3	0.8	2.4	1.6	-0.2	0.7	1.4	0.0	0.3
Townsend deprivation index at recruitment	0.4	0.6	1.5	0.4	-0.7	-1.0	-0.6	0.1	-1.2
Current tobacco smoking	0.9	1.5	3.3	-0.6	-1.7	-1.8	-0.5	-0.4	-1.4
Average weekly fortified wine intake	0.2	0.2	1.0	-1.0	0.0	0.5	-0.2	-0.3	-0.3
Maternal smoking around birth	0.5	0.7	3.0	0.0	-0.6	1.7	1.0	-0.2	-0.3
Fed-up feelings	0.6	1.1	2.9	0.9	0.4	1.0	1.7	1.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	1.5	0.8	1.0	0.5	0.1	0.7
Relative age voice broke	0.2	0.3	0.7	-0.8	0.7	0.3	0.5	0.4	0.5
Taking other prescription medications	1.9	3.0	5.7	-2.4	-1.2	-2.0	-1.6	-0.8	-1.8
Age when periods started (menarche)	0.4	1.1	1.6	0.4	-1.3	1.1	-0.9	-1.1	-1.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.9	0.8	0.8	-0.4	0.4	1.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.7	0.1	1.9	0.4	1.0	-0.1	1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-0.5	-0.9	1.2	0.2	-1.2	-0.7
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	-0.6	0.6	0.5	-0.3	-0.1
Serious illness, injury or assault to yourself	1.1	1.3	2.2	0.2	-1.5	-1.0	-1.5	-0.8	-1.5
High blood pressure	0.6	1.7	5.4	-0.7	-0.4	-2.3	-1.2	1.5	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-1.0	0.2	-0.6	-0.9	0.7	0.0
Multivitamins +/- minerals	1.4	1.8	4.1	-0.5	1.8	1.0	0.6	1.4	2.0
Stomach or abdominal pain in last month	1.3	1.6	4.8	-1.2	-2.2	0.2	-0.2	-0.9	-1.6
Supplements: Glucosamine	0.3	0.4	1.5	1.2	0.4	0.8	-0.0	-0.2	0.0
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	5.4	2.3	0.2	-0.2	0.3	0.6	0.6
Medication: Atenolol	1.1	1.4	4.8	-0.9	-0.6	-2.2	-1.2	1.0	-0.3
Medication: Levothyroxine sodium	0.6	1.0	1.8	-0.4	-0.8	-1.0	-1.1	-1.4	-1.1
Sitting height	0.5	3.6	7.8	1.9	-0.5	1.8	2.6	-2.8	-0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.6	0.5	-0.7	-0.9	-0.3	0.3
High blood pressure (mother)	0.1	0.1	0.5	-0.0	0.7	0.1	0.1	0.2	0.4
Body mass index (BMI)	0.4	1.6	4.5	-0.6	-0.8	-2.1	-1.6	-0.0	-1.1
Impedance of leg (left)	0.1	0.6	1.3	-1.0	-1.1	0.9	0.6	-0.2	-0.3
Leg predicted mass (left)	0.1	0.3	1.1	0.2	-0.2	-0.3	0.1	-1.1	-0.6
Trunk fat mass	0.3	1.1	2.1	-1.1	-1.5	-1.1	-0.4	-0.7	-1.2
Waist circumference	0.8	3.0	6.2	-1.4	-1.6	-2.5	-2.0	-0.8	-1.7
Number of incorrect matches in round	0.4	0.7	2.5	1.6	-0.4	0.2	-1.0	-0.5	-0.5
Past tobacco smoking	2.2	4.1	7.5	1.1	2.0	2.7	2.4	1.2	2.2
Alcohol usually taken with meals	0.2	0.2	1.0	1.0	0.1	-0.1	-0.6	0.2	0.0
Nervous feelings	0.4	0.8	1.9	-0.3	0.4	-1.4	-1.0	1.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.9	0.3	-0.7	-0.9	-1.4	-0.4	-1.0
Hearing difficulty/problems with background noise	2.2	3.5	5.8	-1.2	-1.9	-1.0	-2.4	-1.9	-2.4
Hair/balding pattern: Pattern 2	0.5	0.6	1.9	-0.4	1.4	0.9	0.4	0.7	0.7
Had menopause	0.6	0.7	2.1	0.1	-0.7	-1.5	-0.8	0.5	-0.9
Had other major operations	0.4	0.5	1.9	-1.4	-0.7	-0.3	-0.3	-0.1	-0.8
Forced vital capacity (FVC)	0.4	1.5	4.5	2.1	-1.4	0.7	0.5	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	-0.4	1.7	0.1	0.7	-0.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	0.5	1.0	-0.1	0.3	0.8	0.8
Qualifications: None of the above	0.1	0.3	0.8	0.9	0.1	-0.8	0.2	0.3	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.6	0.2	-0.4	0.2	-0.0	-0.3
Mouth/teeth dental problems	1.0	1.6	7.7	0.7	0.5	2.8	0.9	-0.3	0.3
Heart attack	0.8	1.1	3.6	-0.7	-0.5	-1.9	-0.6	1.3	0.1
Allergy	0.6	1.4	3.3	1.4	0.2	1.8	1.6	-0.5	0.5
Pain all over the body in last month	0.7	0.8	1.4	-0.6	1.2	-1.1	-0.1	1.2	0.3
Diabetes (self-reported)	0.3	0.4	1.2	-0.7	0.4	-0.6	0.4	1.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	-1.1	-0.4	-1.0	-1.0	-0.4	-0.7
Medication: Ramipril	0.2	0.2	0.8	-0.0	0.4	-0.2	0.6	0.9	0.3
Medication: Simvastatin	1.0	1.5	4.6	-1.3	-0.7	-2.1	-1.3	-0.3	-0.8
Fluid intelligence score	0.5	1.1	1.9	1.2	1.1	-0.3	1.0	0.8	1.4
Illnesses of siblings	0.4	0.5	1.1	-1.0	-0.1	1.1	1.0	-0.4	-0.0
Neuroticism score	0.1	0.2	0.6	0.1	0.3	-0.8	-0.2	0.4	-0.3
Weight	0.2	1.2	2.0	-0.8	-1.2	-1.4	-0.7	-1.0	-1.3
Impedance of arm (right)	0.4	1.8	5.3	-0.5	0.1	2.3	2.2	-0.1	0.7
Arm fat percentage (right)	0.4	1.5	2.5	-1.3	-1.2	-1.6	-1.2	-0.4	-1.3
Trunk fat-free mass	0.2	1.3	3.5	0.3	-0.7	-1.1	-0.7	-1.9	-1.4
Hip circumference	0.3	1.2	3.8	-0.4	-1.1	-2.0	-0.9	-0.4	-1.0
Time employed in main current job	0.7	0.9	1.7	1.3	0.7	0.2	1.1	0.7	1.1
Alcohol intake versus 10 years previously	1.0	1.4	3.7	-0.3	1.1	0.4	1.5	1.9	1.1
Father’s age at death	0.3	0.4	0.6	-0.5	0.7	0.7	0.5	-0.7	0.3
Worrier / anxious feelings	0.4	0.7	3.2	-0.2	1.8	-0.1	0.1	0.6	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	0.2	0.2	-1.0	-0.5	0.6	0.2
Falls in the last year	0.4	0.6	1.5	-1.2	0.3	-1.0	-0.8	0.6	0.2
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	-0.3	-0.8	-1.2	-1.1	-0.3	-1.2
Number of live births	1.2	1.7	2.8	-0.9	-1.0	-1.6	-1.7	-1.0	-1.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	9.2	3.0	-1.3	0.5	0.2	-1.1	-1.2
Pulse rate	0.2	0.3	1.2	0.2	0.8	1.1	-0.0	0.1	-0.1
Happiness	1.5	1.8	3.2	1.3	1.2	1.0	1.8	1.1	1.6
Noisy workplace	0.3	0.4	0.8	0.4	-0.8	-0.9	0.5	0.6	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	1.5	0.3	1.5	1.2	0.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-0.9	-1.0	-0.9	-0.6	-0.5	-0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	9.6	0.2	-0.9	-3.1	-0.8	0.5	-0.4
Asthma	0.9	1.7	3.3	-1.8	0.8	-1.8	-0.1	1.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	5.9	2.4	0.4	1.3	-0.1	0.0	-0.1
Medication: Cholesterol lowering	1.0	1.6	4.4	-1.6	-1.0	-2.1	-0.9	0.0	-1.0
Depression (self-reported)	1.1	1.4	2.7	-0.6	-0.3	-1.5	-1.4	-1.6	-0.9
Medication: Lansoprazole	1.0	1.2	4.5	-0.7	-0.3	-2.1	-1.2	-0.3	-0.6
Prospective memory result	1.1	1.4	3.3	-1.3	-0.1	-1.8	0.1	1.8	0.2
Lung cancer (father)	1.3	1.5	2.5	-1.6	-1.2	-1.2	-1.3	-0.7	-1.2
Illnesses of mother	0.6	0.7	2.1	-0.3	0.6	1.5	1.0	0.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	5.4	2.3	-1.9	0.2	-0.1	-1.4	-1.9
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	0.0	0.4	-0.2	0.9	1.4	0.8
Impedance of arm (left)	0.5	2.3	6.5	-0.2	0.3	2.5	2.5	0.3	1.1
Arm fat mass (right)	0.4	1.7	3.5	-0.8	-1.4	-1.9	-1.2	-0.8	-1.5
Trunk predicted mass	0.2	1.2	3.3	0.2	-0.7	-1.1	-0.7	-1.8	-1.4
Standing height	0.2	2.3	6.0	-0.3	-1.1	1.4	1.9	-2.4	-0.9
Length of working week for main job	0.5	0.5	1.1	0.1	-0.9	0.0	-0.3	-1.1	-1.0
Exposure to tobacco smoke at home	1.4	1.5	4.5	-1.0	-1.1	-2.1	-1.1	-0.4	-1.1
Breastfed as a baby	1.2	1.5	3.3	0.9	1.8	1.2	0.5	0.8	1.7
Tense / ‘highly strung’	0.3	0.4	1.4	0.2	0.1	-0.4	-0.5	-1.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	0.9	1.2	-0.7	-0.1	0.4	0.6
Hair/balding pattern: Pattern 4	0.3	0.7	3.6	-1.9	0.2	0.1	-0.2	0.6	0.3
Birth weight of first child	1.8	3.3	8.8	0.8	-1.9	1.4	-0.2	-3.0	-2.1
Peak expiratory flow (PEF)	0.5	1.1	4.0	2.0	-1.1	-0.8	-0.3	0.1	-0.8
Pulse wave reflection index	0.5	0.6	1.7	-0.6	0.3	-0.5	0.3	1.3	1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.6	0.0	1.5	-0.0	1.3	1.6	1.5
Loud music exposure frequency	0.2	0.3	0.8	0.4	-0.2	0.7	0.9	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.4	0.2	-0.3	1.6	0.7	-0.1	-0.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.4	-0.8	-1.0	-1.8	-1.5	-0.4	-0.8
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.3	0.1	-0.9	-0.9	0.1	-0.3
Medication: Paracetamol	2.0	3.3	5.2	-0.0	-2.1	-1.9	-2.3	-1.2	-2.2
Headache pain in last month	0.8	1.3	5.4	2.3	0.8	-0.4	-0.2	1.3	0.3
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	9.5	1.9	1.2	3.1	1.9	-0.3	1.1
Glaucoma (self-reported)	0.5	0.6	3.0	-0.2	0.2	-1.7	-0.1	0.7	0.2
Gout (self-reported)	0.3	0.4	1.8	-0.2	-0.2	0.4	0.1	-1.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.4	0.4	-0.4	-0.6	-1.0	-1.6	-0.9
Medication: Amlodipine	1.4	2.0	5.8	0.5	-1.1	-2.4	-1.8	0.5	-1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.0	-1.4	0.1	-2.0	-1.2	0.8	0.3
Birth weight	0.9	1.9	4.6	1.2	-1.1	1.1	0.2	-2.1	-1.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.6	-0.4	-0.1	-0.5	-0.1	-0.8
High blood pressure (siblings)	1.1	1.5	2.4	0.9	-1.6	-0.8	-1.3	-1.1	-1.5
Forced vital capacity (FVC), Best measure	0.6	2.2	5.2	1.1	-2.3	0.3	-0.1	-1.6	-2.1
Body fat percentage	0.3	1.1	2.1	-1.4	-1.3	-1.2	-0.6	-0.0	-1.0
Leg fat percentage (right)	0.3	1.3	3.3	-1.0	-1.0	-1.8	-1.1	0.1	-1.0
Arm fat-free mass (right)	0.2	1.0	1.4	0.3	-0.9	-1.2	-0.9	-1.2	-1.2
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.3	1.1	0.5	0.8	0.1	0.6
Comparative body size at age 10	0.5	1.4	5.3	-0.4	-0.8	-1.0	-2.3	-0.4	-1.0
Number of full brothers	1.0	1.3	2.8	0.8	-0.6	-1.1	-1.4	-1.7	-0.9
Worry too long after embarrassment	0.3	0.5	1.1	-0.3	-0.1	-0.7	-1.1	-0.6	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.2	0.9	1.8	0.6	1.1	-0.1	1.5
Wheeze or whistling in the chest in last year	1.3	2.3	6.2	-0.6	2.5	-1.0	0.6	1.8	1.7
Number of children fathered	0.8	0.9	1.7	-0.6	-1.3	-1.1	-1.1	-0.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.8	0.5	-0.4	1.3	0.4	0.8	0.1
Age at first live birth	0.5	0.8	2.1	0.1	0.2	1.4	1.4	0.5	0.8
Pulse wave peak to peak time	0.6	0.7	2.8	-0.1	-0.5	0.4	-0.7	-1.7	-0.8
Health satisfaction	0.2	0.2	1.1	1.1	0.3	-0.2	-0.4	0.1	0.0
Shortness of breath walking on level ground	1.4	1.6	5.6	-1.1	-0.5	-2.4	-1.1	1.1	-0.6
Qualifications: College or University degree	0.0	0.1	0.2	0.3	-0.1	0.5	-0.1	0.3	0.5
Eye problems/disorders: None of the above	0.9	1.0	2.6	1.3	-0.1	1.6	0.5	-1.2	-0.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.7	-2.2	-1.8	-0.2	-0.5	-1.0	-1.4
Emphysema/chronic bronchitis	0.5	0.6	1.4	-1.2	0.7	-0.2	-0.8	0.9	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	-1.3	0.8	1.4	0.9	-0.2	0.7
Neck or shoulder pain in last month	0.4	0.6	1.4	0.5	-0.9	0.7	-0.7	0.1	-1.2
Medication: Blood pressure	2.5	4.3	11.6	-1.8	-1.8	-3.4	-2.4	-0.1	-1.5
Angina (self-reported)	0.2	0.3	1.1	-0.4	-0.1	-1.1	-0.8	0.1	-0.0
Migraine (self-reported)	0.8	1.0	2.4	1.5	0.7	-0.5	-0.4	1.5	0.8
Medication: Ibuprofen	1.2	1.4	5.7	2.4	-0.0	1.4	-0.5	-0.5	-0.7
Medication: Allopurinol	0.1	0.1	0.8	0.9	-0.0	0.1	0.1	0.2	-0.2
Medication: Omeprazole	1.6	1.9	3.9	-0.9	-1.8	-0.4	-0.9	-2.0	-1.6
Medication: Seretide 50 evohaler	0.6	0.7	2.1	-1.0	0.0	-0.9	-0.3	1.4	-0.1
Mean time to correctly identify matches	2.3	4.3	6.9	-2.5	-1.1	-2.2	-2.6	-1.8	-1.8
Heart disease (mother)	0.6	0.7	2.5	0.5	-0.0	-1.6	-0.4	1.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.4	0.6	0.0	0.5	0.1	0.3
Whole body fat mass	0.4	1.5	2.2	-1.5	-1.4	-1.4	-0.7	-0.7	-1.3
Leg fat mass (right)	0.4	1.4	2.8	-1.0	-1.3	-1.7	-1.0	-0.5	-1.2
Arm predicted mass (right)	0.2	1.1	1.8	0.5	-1.0	-1.4	-0.9	-1.2	-1.3
Pulse rate, automated reading	0.5	1.5	6.1	-0.2	1.1	2.5	0.9	-0.7	0.7
Alcohol intake frequency.	0.4	0.9	1.7	-1.0	0.4	-1.3	-1.3	0.9	-0.4
Comparative height size at age 10	0.4	2.0	6.4	-0.9	-1.6	0.7	0.5	-2.5	-1.3
Number of full sisters	1.4	1.7	4.0	0.7	2.0	1.2	0.9	0.6	1.7
Suffer from ‘nerves’	0.6	1.0	3.2	0.6	0.7	-0.8	0.4	1.8	1.0
Overall health rating	0.8	1.7	2.8	-1.7	-0.8	0.1	-1.1	-1.6	-1.6
Chest pain or discomfort	0.6	0.8	2.2	0.0	1.5	-0.1	0.4	1.2	1.0
Had major operations	0.5	0.5	1.0	-1.0	0.4	0.8	0.9	-0.8	-0.1
Age at last live birth	0.5	0.7	2.7	-1.6	-0.5	0.8	0.4	-0.8	-0.2
Family relationship satisfaction	1.2	1.5	3.1	0.7	1.3	0.7	1.3	1.2	1.8
Leg pain on walking	1.1	1.3	2.7	-0.3	-1.1	-1.6	-1.5	-0.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.8	-2.0	-1.5	-0.4	-0.6	-1.8	-1.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.3	-0.4	1.1	0.4	-1.0	-0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.4	1.1	0.5	0.4	0.9	1.2
Medication: Aspirin	1.1	1.4	4.3	-0.1	0.6	-1.4	0.6	2.1	1.2
Supplements: Vitamin C	0.6	0.7	1.2	0.3	1.1	0.9	0.7	0.7	1.1
Knee pain experienced in last month	0.7	1.1	2.9	-0.8	-1.7	0.1	-0.6	-0.6	-1.6
Hypertension (Self-reported)	0.8	2.2	7.1	-0.5	-0.8	-2.7	-1.6	1.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.7	-1.1	-1.2	-0.2	-0.4	-1.3	-1.0
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.1	0.3	-0.8	-0.4	0.2	-0.1
Illnesses of siblings: Diabetes	0.6	0.8	3.6	0.1	0.2	-1.9	-0.9	-0.3	0.0
Smoking status: Previous	0.8	1.2	2.4	-0.5	-1.1	-1.2	-1.6	-0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	8.6	-0.6	0.3	2.9	2.0	-0.6	0.2
Whole body fat-free mass	0.2	1.0	2.5	0.2	-0.7	-1.0	-0.6	-1.6	-1.2
Leg fat-free mass (right)	0.1	0.5	1.5	-0.1	-0.6	-0.5	-0.2	-1.2	-0.9
Arm fat percentage (left)	0.2	0.8	1.5	-0.9	-0.9	-1.2	-0.8	-0.1	-0.9
Average weekly red wine intake	0.6	0.9	2.9	-0.5	-0.5	-0.5	-1.7	-0.7	-1.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.0	0.2	-0.9	-0.4	0.4	-0.2
Mood swings	0.7	1.3	1.9	1.4	1.3	0.9	1.4	0.7	1.2
Loneliness, isolation	0.4	0.5	1.3	0.5	1.1	-0.5	0.4	1.1	0.5
Long-standing illness, disability or infirmity	1.6	2.4	6.0	-1.1	-1.1	-1.8	-2.4	-0.3	-1.6
Ever had bowel cancer screening	0.1	0.2	0.8	-0.9	0.1	0.0	-0.1	-0.4	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.3	0.1	-0.7	0.1	0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.4	0.0	-0.9	0.2	-0.3	-0.2
Friendships satisfaction	1.2	1.4	3.5	0.5	1.8	0.2	1.1	0.8	1.9
Qualifications: nursing, teaching	0.4	0.6	2.7	-0.4	-0.5	-0.6	-1.6	0.1	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.5	0.9	-0.3	-0.2	0.3	0.5
Eye problems/disorders: Cataract	1.1	1.3	3.6	-1.4	-0.8	-1.9	-0.5	1.0	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.1	-1.8	0.4	0.7	-0.3	-1.7	-0.3
Medication for cholesterol	1.2	1.8	5.3	0.3	-1.0	1.7	0.7	-2.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	-0.3	-1.1	-0.8	-0.2	0.1	-0.8
Back pain experienced in last month	0.4	0.5	0.9	-0.3	-0.9	-0.4	-0.6	0.9	-1.0
Mineral and other dietary supplements	0.2	0.3	0.8	0.1	-0.7	-0.9	0.3	0.3	-0.6
Breast cancer (self-reported)	0.4	0.5	1.7	0.4	-1.3	-0.5	-0.4	-0.4	-0.8
Asthma (self-reported)	1.0	2.0	3.7	-1.9	1.0	-1.8	-0.1	1.9	0.9
Osteoporosis (self-reported)	0.8	1.0	1.6	-1.1	-1.3	-0.8	-0.4	-1.1	-0.9
Osteoarthritis (self-reported)	0.6	0.8	2.1	1.5	-0.5	-1.0	-0.4	0.1	-1.0
Medication: Aspirin	1.0	1.3	4.0	-0.0	0.1	-1.9	-0.0	2.0	0.7
Medication: Gliclazide	2.8	3.2	5.3	-1.7	-2.2	-0.8	-1.8	-1.4	-2.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.7	0.3	1.1	1.0	0.3	0.3
Smoking status: Current	1.2	1.9	4.5	-0.5	-1.8	-2.1	-0.8	-0.6	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.6	1.9	-1.3	-1.6	-1.1	-0.0	-1.1
Whole body water mass	0.2	1.0	2.7	0.1	-0.8	-0.9	-0.5	-1.6	-1.3
Leg predicted mass (right)	0.1	0.5	1.5	-0.1	-0.6	-0.5	-0.3	-1.2	-1.0
Arm fat mass (left)	0.3	1.2	2.2	-0.5	-1.2	-1.5	-1.0	-0.8	-1.3
Number of self-reported non-cancer illnesses	1.5	2.6	9.0	-0.7	-0.6	-3.0	-1.9	0.8	-1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.3	0.2	0.7	-0.6	-0.4	-0.3
Miserableness	0.2	0.4	1.1	-1.1	-0.5	-0.0	0.0	-0.5	-0.8
Guilty feelings	1.0	1.5	3.3	1.4	-1.3	-1.1	-1.0	-0.1	-1.8
Wears glasses or contact lenses	1.3	1.5	3.9	-0.4	-1.2	-1.2	-0.9	-2.0	-1.2
Ever taken oral contraceptive pill	0.8	0.9	2.7	1.0	0.4	0.5	1.0	1.6	0.8
Hearing aid user	0.2	0.2	0.6	-0.1	0.4	0.5	0.6	0.1	0.8
Mother’s age at death	2.0	2.5	4.1	1.7	2.0	0.4	1.0	1.6	2.0
Financial situation satisfaction	1.5	1.9	3.2	0.6	1.4	0.9	1.8	1.7	1.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.9	-0.7	-0.0	-0.4	0.5	-0.5
Commuting to job workplace: Public transport	0.5	0.6	1.7	1.3	0.5	-0.2	0.1	1.2	0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	0.6	1.1	-1.0	0.7	1.7	1.1
Medication: Blood pressure	1.2	2.2	5.5	0.1	-1.1	-2.3	-1.9	1.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	1.6	0.7	0.4	0.5	1.2	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-0.1	0.8	1.5	0.1	-0.6	0.9
High cholesterol (Self-reported)	1.9	3.4	6.2	-1.1	-1.6	-2.5	-2.2	-1.1	-2.1
Medication: Bendroflumethiazide	0.5	0.8	1.5	-0.4	-0.0	-1.2	-1.2	1.2	0.5
Medication: Paracetamol	2.4	3.8	6.6	-0.1	-2.5	-1.4	-2.5	-1.4	-2.6
Medication: Lisinopril	0.5	0.7	1.8	0.6	0.2	-1.3	-1.0	0.9	0.2
Medication: Atorvastatin	1.0	1.2	3.6	0.1	0.5	-1.6	0.3	1.9	0.9
Illnesses of father: High blood pressure	2.0	2.5	3.8	-1.7	-1.3	-1.7	-1.9	-0.6	-1.7
Alcohol drinker status: Never	0.5	0.6	2.0	-1.4	0.0	-0.3	-0.9	-0.6	-0.8
Ever smoked	1.2	2.2	5.3	-0.6	-1.1	-2.3	-1.8	-0.9	-1.4
Basal metabolic rate	0.2	1.0	2.4	-0.0	-0.8	-0.9	-0.5	-1.6	-1.3
Leg fat percentage (left)	0.4	1.3	3.4	-1.1	-1.1	-1.9	-1.1	0.2	-1.0
Arm fat-free mass (left)	0.3	1.3	2.4	0.1	-1.0	-1.6	-0.9	-1.2	-1.4
Number of operations (self-reported)	1.3	2.0	3.4	-1.5	-1.3	-1.8	-1.2	-0.5	-1.6
Average weekly beer plus cider intake	0.7	1.0	2.9	-1.7	-1.0	0.2	0.0	-1.0	-0.9
Irritability	0.9	1.5	3.0	1.7	0.7	1.3	1.7	0.3	0.8
Risk taking	1.3	1.9	4.8	1.7	-0.3	2.2	0.9	-1.7	-0.3
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.0	1.5	-2.2	0.0	-1.1	-1.9	-1.9
Fractured/broken bones in last 5 years	1.0	1.2	2.9	1.7	-1.3	-0.5	0.4	-1.2	-0.9
Age started oral contraceptive pill	1.6	2.0	4.7	-0.2	-1.3	-2.2	-2.0	-0.9	-1.0
Diastolic blood pressure, automated reading	0.4	1.1	5.5	-2.4	0.8	-0.5	-0.5	0.3	0.3
Ever depressed for a whole week	0.0	0.0	0.1	-0.2	-0.2	0.1	0.0	-0.3	-0.2
Unable to work because of sickness or disability	0.2	0.3	1.0	1.0	-0.1	0.6	0.4	-0.0	0.2
Commuting to job workplace: Cycle	3.5	4.3	9.1	3.0	2.4	0.4	1.2	2.1	2.2
Myopia	0.8	1.1	1.9	-1.3	-0.3	1.1	1.3	-1.4	0.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.9	1.0	0.7	2.8	1.6	-1.6	0.5
Cholesterol lowering medication	0.7	1.1	3.3	0.6	0.8	-1.8	-0.8	1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.2	-0.9	-1.4	-0.6	-1.0	-1.5	-1.4
Pain experienced in last month	0.5	0.8	4.0	-0.6	-0.1	-0.5	-0.0	-2.0	0.2
Supplements: Calcium	1.7	1.9	3.6	-1.9	1.3	1.5	1.3	0.2	1.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	1.0	-0.6	-0.9	-1.4	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.8	-0.6	-0.5	-1.9	-0.7	1.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	-0.6	-0.1	-1.3	-1.3	-0.1	-0.5
Heart disease (siblings)	0.8	0.9	1.8	1.1	1.0	-1.0	-0.1	0.7	1.3
Alcohol drinker status: Previous	0.4	0.4	1.1	0.9	0.4	0.1	-1.1	-0.6	-0.4
Pack years of smoking	0.6	0.8	1.4	0.7	1.1	0.3	1.2	0.5	1.2
Impedance of whole body	0.3	1.5	4.2	-0.6	-0.2	2.1	2.0	0.3	0.7
Leg fat mass (left)	0.3	1.1	2.3	-0.9	-1.2	-1.5	-0.9	-0.4	-1.1
Arm predicted mass (left)	0.4	1.9	2.9	-0.2	-1.3	-1.6	-1.2	-1.7	-1.7