TWAS hub - ZUFSP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2438	0.0762	0.00048	0.034	NA	0.100	NA	0.091	0.0220	NA	0.00020	NA	0.00037
2	TCGA	Breast Invasive Carcinoma	0.0309	0.0169	0.00021	0.005	0.013	0.016	NA	0.011	0.0270	0.00081	0.00025	NA	0.00160
3	TCGA	Colon Adenocarcinoma	0.0490	0.0380	0.00980	0.040	0.028	0.026	NA	0.037	0.0024	0.00970	0.01200	NA	0.00330
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0256	0.0164	0.00240	0.014	0.025	0.020	NA	0.016	0.0088	0.00068	0.00240	NA	0.00550
5	TCGA	Brain Lower Grade Glioma	0.1110	0.0590	0.00078	0.023	0.022	0.018	NA	0.010	0.0011	0.00130	0.00310	NA	0.02300
6	TCGA	Prostate Adenocarcinoma	0.0274	0.0177	0.00620	0.005	0.016	0.016	NA	0.009	0.0870	0.00780	0.00680	NA	0.03400

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Commuting to job workplace: Cycle	3.5	4.3	9.1	3.0	2.4	0.4	1.2	2.1	2.2
Bipolar Disorder (2011)	3.0	2.9	4.4	-0.8	-2.1	-1.4	-2.0	-1.3	-2.1
Medication: Gliclazide	2.8	3.2	5.3	-1.7	-2.2	-0.8	-1.8	-1.4	-2.3
Schizophrenia (2018)	2.6	5.4	8.9	0.3	2.9	1.6	2.5	2.5	3.0
Medication: Blood pressure	2.5	4.3	11.6	-1.8	-1.8	-3.4	-2.4	-0.1	-1.5
Number of treatments/medications taken	2.4	4.3	12.2	-1.2	-1.2	-3.5	-2.7	1.2	-1.6
Medication: Paracetamol	2.4	3.8	6.6	-0.1	-2.5	-1.4	-2.5	-1.4	-2.6
Mean time to correctly identify matches	2.3	4.3	6.9	-2.5	-1.1	-2.2	-2.6	-1.8	-1.8
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.0	1.5	-2.2	0.0	-1.1	-1.9	-1.9
Body Mass Index (BMI) (2010)	2.2	3.0	5.4	-0.4	-2.0	-2.3	-2.3	0.3	-1.9
Schizophrenia (2014)	2.2	4.8	7.8	0.8	2.4	1.1	2.4	2.8	2.7
Past tobacco smoking	2.2	4.1	7.5	1.1	2.0	2.7	2.4	1.2	2.2
Hearing difficulty/problems with background noise	2.2	3.5	5.8	-1.2	-1.9	-1.0	-2.4	-1.9	-2.4
Schizophrenia vs Biploar Disorder	2.1	2.8	5.0	-0.5	2.0	0.7	1.8	1.9	2.2
Reaction Time	2.0	3.8	6.0	-2.3	-1.0	-2.1	-2.5	-1.5	-1.9
Primary Biliary Cirrhosis	2.0	2.8	5.5	0.8	1.9	0.1	1.7	2.3	2.0
Medication: Paracetamol	2.0	3.3	5.2	-0.0	-2.1	-1.9	-2.3	-1.2	-2.2
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	9.5	1.9	1.2	3.1	1.9	-0.3	1.1
Mother’s age at death	2.0	2.5	4.1	1.7	2.0	0.4	1.0	1.6	2.0
Illnesses of father: High blood pressure	2.0	2.5	3.8	-1.7	-1.3	-1.7	-1.9	-0.6	-1.7
Taking other prescription medications	1.9	3.0	5.7	-2.4	-1.2	-2.0	-1.6	-0.8	-1.8
High cholesterol (Self-reported)	1.9	3.4	6.2	-1.1	-1.6	-2.5	-2.2	-1.1	-2.1
Medication for hormone replacement therapy	1.8	2.0	3.0	-0.9	1.7	1.6	1.6	0.6	1.7
Birth weight of first child	1.8	3.3	8.8	0.8	-1.9	1.4	-0.2	-3.0	-2.1
Smoking Status	1.7	4.1	8.1	-1.0	-2.2	-2.8	-1.8	-1.1	-2.4
Supplements: Calcium	1.7	1.9	3.6	-1.9	1.3	1.5	1.3	0.2	1.3
Major Depression (MDD)	1.6	2.0	3.6	-0.9	-0.6	-1.9	-1.9	-1.4	-1.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.7	-2.2	-1.8	-0.2	-0.5	-1.0	-1.4
Medication: Omeprazole	1.6	1.9	3.9	-0.9	-1.8	-0.4	-0.9	-2.0	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.8	-2.0	-1.5	-0.4	-0.6	-1.8	-1.5
Long-standing illness, disability or infirmity	1.6	2.4	6.0	-1.1	-1.1	-1.8	-2.4	-0.3	-1.6
Age started oral contraceptive pill	1.6	2.0	4.7	-0.2	-1.3	-2.2	-2.0	-0.9	-1.0
Ulcerative Colitis	1.5	2.1	6.3	-0.7	-1.2	1.8	0.7	-2.5	-1.0
Medication: Metformin	1.5	2.1	4.4	-2.1	-1.3	-1.6	-1.3	-0.4	-1.4
Happiness	1.5	1.8	3.2	1.3	1.2	1.0	1.8	1.1	1.6
Number of self-reported non-cancer illnesses	1.5	2.6	9.0	-0.7	-0.6	-3.0	-1.9	0.8	-1.1
Financial situation satisfaction	1.5	1.9	3.2	0.6	1.4	0.9	1.8	1.7	1.4
Triglycerides	1.4	2.3	5.1	-0.1	-1.6	-1.7	-2.2	-0.7	-1.7
Waist Hip Ratio (WHR)	1.4	6.1	12.6	-1.9	-2.1	-3.0	-3.5	-1.3	-2.3
Lung FEV1/FVC ratio	1.4	7.0	28.1	5.3	-1.4	-2.1	-1.6	-1.7	-1.4
Multivitamins +/- minerals	1.4	1.8	4.1	-0.5	1.8	1.0	0.6	1.4	2.0
Exposure to tobacco smoke at home	1.4	1.5	4.5	-1.0	-1.1	-2.1	-1.1	-0.4	-1.1
Medication: Amlodipine	1.4	2.0	5.8	0.5	-1.1	-2.4	-1.8	0.5	-1.0
Shortness of breath walking on level ground	1.4	1.6	5.6	-1.1	-0.5	-2.4	-1.1	1.1	-0.6
Number of full sisters	1.4	1.7	4.0	0.7	2.0	1.2	0.9	0.6	1.7
Bipolar Disorder or Schizophrenia	1.3	3.1	5.5	0.7	2.0	1.0	1.6	2.3	2.1
Crohns Disease (2017)	1.3	2.9	7.1	-2.4	1.2	2.7	1.4	0.2	1.1
Stomach or abdominal pain in last month	1.3	1.6	4.8	-1.2	-2.2	0.2	-0.2	-0.9	-1.6
Lung cancer (father)	1.3	1.5	2.5	-1.6	-1.2	-1.2	-1.3	-0.7	-1.2
Wheeze or whistling in the chest in last year	1.3	2.3	6.2	-0.6	2.5	-1.0	0.6	1.8	1.7
Wears glasses or contact lenses	1.3	1.5	3.9	-0.4	-1.2	-1.2	-0.9	-2.0	-1.2
Number of operations (self-reported)	1.3	2.0	3.4	-1.5	-1.3	-1.8	-1.2	-0.5	-1.6
Risk taking	1.3	1.9	4.8	1.7	-0.3	2.2	0.9	-1.7	-0.3
Cardiovascular Disease	1.2	4.1	11.5	-1.4	-0.9	-3.4	-2.8	1.2	-1.2
Number of live births	1.2	1.7	2.8	-0.9	-1.0	-1.6	-1.7	-1.0	-1.5
Breastfed as a baby	1.2	1.5	3.3	0.9	1.8	1.2	0.5	0.8	1.7
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.6	0.0	1.5	-0.0	1.3	1.6	1.5
Medication: Ibuprofen	1.2	1.4	5.7	2.4	-0.0	1.4	-0.5	-0.5	-0.7
Family relationship satisfaction	1.2	1.5	3.1	0.7	1.3	0.7	1.3	1.2	1.8
Friendships satisfaction	1.2	1.4	3.5	0.5	1.8	0.2	1.1	0.8	1.9
Medication for cholesterol	1.2	1.8	5.3	0.3	-1.0	1.7	0.7	-2.3	-0.8
Smoking status: Current	1.2	1.9	4.5	-0.5	-1.8	-2.1	-0.8	-0.6	-1.5
Medication: Blood pressure	1.2	2.2	5.5	0.1	-1.1	-2.3	-1.9	1.4	-1.0
Ever smoked	1.2	2.2	5.3	-0.6	-1.1	-2.3	-1.8	-0.9	-1.4
Irritable Bowel Disease (IBD)	1.1	2.5	10.6	-0.9	0.2	3.3	1.7	-0.8	0.3
Ulcerative Colitis (UC)	1.1	2.0	6.7	0.7	-0.4	2.6	1.9	-0.9	-0.2
Chronotype (morning person)	1.1	2.6	4.1	1.5	1.8	1.4	1.8	0.9	2.0
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.3	0.3	-1.4	-0.5	-1.5	-1.0	-1.3
Serious illness, injury or assault to yourself	1.1	1.3	2.2	0.2	-1.5	-1.0	-1.5	-0.8	-1.5
Medication: Atenolol	1.1	1.4	4.8	-0.9	-0.6	-2.2	-1.2	1.0	-0.3
Mouth/teeth dental problems: Dentures	1.1	1.9	9.6	0.2	-0.9	-3.1	-0.8	0.5	-0.4
Depression (self-reported)	1.1	1.4	2.7	-0.6	-0.3	-1.5	-1.4	-1.6	-0.9
Prospective memory result	1.1	1.4	3.3	-1.3	-0.1	-1.8	0.1	1.8	0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.0	-1.4	0.1	-2.0	-1.2	0.8	0.3
High blood pressure (siblings)	1.1	1.5	2.4	0.9	-1.6	-0.8	-1.3	-1.1	-1.5
Leg pain on walking	1.1	1.3	2.7	-0.3	-1.1	-1.6	-1.5	-0.7	-1.1
Medication: Aspirin	1.1	1.4	4.3	-0.1	0.6	-1.4	0.6	2.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	8.6	-0.6	0.3	2.9	2.0	-0.6	0.2
Eye problems/disorders: Cataract	1.1	1.3	3.6	-1.4	-0.8	-1.9	-0.5	1.0	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.2	-0.9	-1.4	-0.6	-1.0	-1.5	-1.4
LDL Cholesterol	1.0	1.6	2.8	0.2	-1.7	-0.8	-1.0	-1.6	-1.6
Supplements: Zinc	1.0	1.1	1.8	-0.1	1.2	1.4	0.6	1.2	1.3
Mouth/teeth dental problems	1.0	1.6	7.7	0.7	0.5	2.8	0.9	-0.3	0.3
Medication: Simvastatin	1.0	1.5	4.6	-1.3	-0.7	-2.1	-1.3	-0.3	-0.8
Alcohol intake versus 10 years previously	1.0	1.4	3.7	-0.3	1.1	0.4	1.5	1.9	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	5.9	2.4	0.4	1.3	-0.1	0.0	-0.1
Medication: Cholesterol lowering	1.0	1.6	4.4	-1.6	-1.0	-2.1	-0.9	0.0	-1.0
Medication: Lansoprazole	1.0	1.2	4.5	-0.7	-0.3	-2.1	-1.2	-0.3	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.4	-0.8	-1.0	-1.8	-1.5	-0.4	-0.8
Number of full brothers	1.0	1.3	2.8	0.8	-0.6	-1.1	-1.4	-1.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.2	0.9	1.8	0.6	1.1	-0.1	1.5
Asthma (self-reported)	1.0	2.0	3.7	-1.9	1.0	-1.8	-0.1	1.9	0.9
Medication: Aspirin	1.0	1.3	4.0	-0.0	0.1	-1.9	-0.0	2.0	0.7
Guilty feelings	1.0	1.5	3.3	1.4	-1.3	-1.1	-1.0	-0.1	-1.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	0.6	1.1	-1.0	0.7	1.7	1.1
Medication: Atorvastatin	1.0	1.2	3.6	0.1	0.5	-1.6	0.3	1.9	0.9
Fractured/broken bones in last 5 years	1.0	1.2	2.9	1.7	-1.3	-0.5	0.4	-1.2	-0.9
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	-0.2	-1.5	0.3	-0.2	-1.7	-0.9
Fasting Glucose	0.9	1.0	2.1	0.2	-1.2	-0.9	-0.6	-1.4	-1.2
Hypothyroidism (self reported)	0.9	2.1	5.8	-0.9	-0.8	-1.2	-1.3	-2.4	-1.4
Severe depression (siblings)	0.9	1.1	2.0	-1.1	-1.1	-1.4	-1.1	0.6	-0.4
Current tobacco smoking	0.9	1.5	3.3	-0.6	-1.7	-1.8	-0.5	-0.4	-1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	5.4	2.3	0.2	-0.2	0.3	0.6	0.6
Asthma	0.9	1.7	3.3	-1.8	0.8	-1.8	-0.1	1.6	0.8
Birth weight	0.9	1.9	4.6	1.2	-1.1	1.1	0.2	-2.1	-1.6
Eye problems/disorders: None of the above	0.9	1.0	2.6	1.3	-0.1	1.6	0.5	-1.2	-0.3
Irritability	0.9	1.5	3.0	1.7	0.7	1.3	1.7	0.3	0.8
Vascular/heart problems diagnosed by doctor	0.9	2.4	7.9	1.0	0.7	2.8	1.6	-1.6	0.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.8	-0.6	-0.5	-1.9	-0.7	1.4	0.1
Crohns Disease (2012)	0.8	1.3	3.7	-1.9	0.0	1.7	1.0	0.1	0.1
Lupus	0.8	1.2	4.5	-0.5	0.8	2.1	1.1	-0.1	0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.0	0.2	-1.4	-1.4	-1.0	0.0	-0.6
Blood Eosinophil Count	0.8	6.1	22.5	-4.7	-0.0	-2.8	-1.0	2.2	0.7
Respiratory disease	0.8	1.8	3.2	-1.5	1.6	-1.0	0.1	1.8	1.4
Lung FVC	0.8	4.1	9.2	1.1	-3.0	-1.2	-1.7	-1.3	-2.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.1	-0.4	-1.1	-0.3	-1.5	-1.0	-1.4
Vitamin and mineral supplements	0.8	1.1	3.2	0.1	-1.5	-0.3	-0.2	-1.1	-1.8
Waist circumference	0.8	3.0	6.2	-1.4	-1.6	-2.5	-2.0	-0.8	-1.7
Heart attack	0.8	1.1	3.6	-0.7	-0.5	-1.9	-0.6	1.3	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	5.4	2.3	-1.9	0.2	-0.1	-1.4	-1.9
Headache pain in last month	0.8	1.3	5.4	2.3	0.8	-0.4	-0.2	1.3	0.3
Number of children fathered	0.8	0.9	1.7	-0.6	-1.3	-1.1	-1.1	-0.1	-1.1
Migraine (self-reported)	0.8	1.0	2.4	1.5	0.7	-0.5	-0.4	1.5	0.8
Overall health rating	0.8	1.7	2.8	-1.7	-0.8	0.1	-1.1	-1.6	-1.6
Hypertension (Self-reported)	0.8	2.2	7.1	-0.5	-0.8	-2.7	-1.6	1.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.7	-1.1	-1.2	-0.2	-0.4	-1.3	-1.0
Smoking status: Previous	0.8	1.2	2.4	-0.5	-1.1	-1.2	-1.6	-0.6	-1.4
Osteoporosis (self-reported)	0.8	1.0	1.6	-1.1	-1.3	-0.8	-0.4	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.6	1.9	-1.3	-1.6	-1.1	-0.0	-1.1
Ever taken oral contraceptive pill	0.8	0.9	2.7	1.0	0.4	0.5	1.0	1.6	0.8
Myopia	0.8	1.1	1.9	-1.3	-0.3	1.1	1.3	-1.4	0.3
Heart disease (siblings)	0.8	0.9	1.8	1.1	1.0	-1.0	-0.1	0.7	1.3
Ovarian Cancer	0.7	1.0	2.1	0.3	1.4	-0.7	0.3	1.4	1.0
HbA1C	0.7	0.8	2.9	-0.3	-0.7	-1.7	-0.7	-0.7	-0.5
Average weekly spirits intake	0.7	0.9	2.2	-0.7	-0.4	-1.5	-1.0	0.9	-0.8
Hearing difficulty/problems: Yes	0.7	1.0	1.5	-0.9	-1.2	-1.2	-1.2	0.2	-0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.5	-0.5	-0.9	1.2	0.2	-1.2	-0.7
Pain all over the body in last month	0.7	0.8	1.4	-0.6	1.2	-1.1	-0.1	1.2	0.3
Time employed in main current job	0.7	0.9	1.7	1.3	0.7	0.2	1.1	0.7	1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	9.2	3.0	-1.3	0.5	0.2	-1.1	-1.2
Knee pain experienced in last month	0.7	1.1	2.9	-0.8	-1.7	0.1	-0.6	-0.6	-1.6
Mood swings	0.7	1.3	1.9	1.4	1.3	0.9	1.4	0.7	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.1	-1.8	0.4	0.7	-0.3	-1.7	-0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.6	1.6	0.7	0.4	0.5	1.2	0.7
Average weekly beer plus cider intake	0.7	1.0	2.9	-1.7	-1.0	0.2	0.0	-1.0	-0.9
Cholesterol lowering medication	0.7	1.1	3.3	0.6	0.8	-1.8	-0.8	1.1	0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.1	1.4	-0.3	-1.2	-0.5	-0.5	0.1
Sensitivity / hurt feelings	0.6	1.0	3.2	-0.7	-0.3	-1.2	-1.8	-0.1	-0.8
Relative age of first facial hair	0.6	1.3	2.4	0.6	1.2	0.9	1.6	1.2	1.2
Fed-up feelings	0.6	1.1	2.9	0.9	0.4	1.0	1.7	1.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.2	1.5	0.8	1.0	0.5	0.1	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	1.9	0.8	0.8	-0.4	0.4	1.4	0.6
High blood pressure	0.6	1.7	5.4	-0.7	-0.4	-2.3	-1.2	1.5	-0.2
Medication: Levothyroxine sodium	0.6	1.0	1.8	-0.4	-0.8	-1.0	-1.1	-1.4	-1.1
Had menopause	0.6	0.7	2.1	0.1	-0.7	-1.5	-0.8	0.5	-0.9
Allergy	0.6	1.4	3.3	1.4	0.2	1.8	1.6	-0.5	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-0.9	-1.0	-0.9	-0.6	-0.5	-0.9
Illnesses of mother	0.6	0.7	2.1	-0.3	0.6	1.5	1.0	0.3	0.9
Forced vital capacity (FVC), Best measure	0.6	2.2	5.2	1.1	-2.3	0.3	-0.1	-1.6	-2.1
Pulse wave peak to peak time	0.6	0.7	2.8	-0.1	-0.5	0.4	-0.7	-1.7	-0.8
Medication: Seretide 50 evohaler	0.6	0.7	2.1	-1.0	0.0	-0.9	-0.3	1.4	-0.1
Heart disease (mother)	0.6	0.7	2.5	0.5	-0.0	-1.6	-0.4	1.1	0.2
Suffer from ‘nerves’	0.6	1.0	3.2	0.6	0.7	-0.8	0.4	1.8	1.0
Chest pain or discomfort	0.6	0.8	2.2	0.0	1.5	-0.1	0.4	1.2	1.0
Supplements: Vitamin C	0.6	0.7	1.2	0.3	1.1	0.9	0.7	0.7	1.1
Illnesses of siblings: Diabetes	0.6	0.8	3.6	0.1	0.2	-1.9	-0.9	-0.3	0.0
Average weekly red wine intake	0.6	0.9	2.9	-0.5	-0.5	-0.5	-1.7	-0.7	-1.1
Osteoarthritis (self-reported)	0.6	0.8	2.1	1.5	-0.5	-1.0	-0.4	0.1	-1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	1.0	-0.6	-0.9	-1.4	0.1	-0.5
Pack years of smoking	0.6	0.8	1.4	0.7	1.1	0.3	1.2	0.5	1.2
Blood White Count	0.5	3.9	11.9	3.5	0.7	-1.8	0.2	2.5	1.3
BMI	0.5	2.9	7.3	-0.2	-1.2	-2.5	-2.7	-0.5	-1.4
Neuroticism	0.5	1.1	2.4	-0.7	-0.5	-1.5	-1.6	-0.3	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	2.2	0.4	-0.1	-1.5	-0.8	0.8	-0.2
Medication: Co-codamol	0.5	0.6	1.7	0.8	0.3	1.3	0.8	0.3	0.4
Diabetes (mother)	0.5	0.6	1.8	1.1	-0.4	-1.3	-0.5	0.4	-0.1
Maternal smoking around birth	0.5	0.7	3.0	0.0	-0.6	1.7	1.0	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.7	0.1	1.9	0.4	1.0	-0.1	1.4
Sitting height	0.5	3.6	7.8	1.9	-0.5	1.8	2.6	-2.8	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.9	0.3	-0.7	-0.9	-1.4	-0.4	-1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.9	-0.4	1.4	0.9	0.4	0.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.1	-1.1	-0.4	-1.0	-1.0	-0.4	-0.7
Fluid intelligence score	0.5	1.1	1.9	1.2	1.1	-0.3	1.0	0.8	1.4
Hair/balding pattern: Pattern 3	0.5	0.8	1.4	-0.3	-0.8	-1.2	-1.1	-0.3	-1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	1.5	0.3	1.5	1.2	0.6	0.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	0.0	0.4	-0.2	0.9	1.4	0.8
Impedance of arm (left)	0.5	2.3	6.5	-0.2	0.3	2.5	2.5	0.3	1.1
Length of working week for main job	0.5	0.5	1.1	0.1	-0.9	0.0	-0.3	-1.1	-1.0
Peak expiratory flow (PEF)	0.5	1.1	4.0	2.0	-1.1	-0.8	-0.3	0.1	-0.8
Pulse wave reflection index	0.5	0.6	1.7	-0.6	0.3	-0.5	0.3	1.3	1.2
Glaucoma (self-reported)	0.5	0.6	3.0	-0.2	0.2	-1.7	-0.1	0.7	0.2
Comparative body size at age 10	0.5	1.4	5.3	-0.4	-0.8	-1.0	-2.3	-0.4	-1.0
Age at first live birth	0.5	0.8	2.1	0.1	0.2	1.4	1.4	0.5	0.8
Emphysema/chronic bronchitis	0.5	0.6	1.4	-1.2	0.7	-0.2	-0.8	0.9	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	-1.3	0.8	1.4	0.9	-0.2	0.7
Pulse rate, automated reading	0.5	1.5	6.1	-0.2	1.1	2.5	0.9	-0.7	0.7
Had major operations	0.5	0.5	1.0	-1.0	0.4	0.8	0.9	-0.8	-0.1
Age at last live birth	0.5	0.7	2.7	-1.6	-0.5	0.8	0.4	-0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.4	1.1	0.5	0.4	0.9	1.2
Commuting to job workplace: Public transport	0.5	0.6	1.7	1.3	0.5	-0.2	0.1	1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.1	-0.1	0.8	1.5	0.1	-0.6	0.9
Medication: Bendroflumethiazide	0.5	0.8	1.5	-0.4	-0.0	-1.2	-1.2	1.2	0.5
Medication: Lisinopril	0.5	0.7	1.8	0.6	0.2	-1.3	-1.0	0.9	0.2
Alcohol drinker status: Never	0.5	0.6	2.0	-1.4	0.0	-0.3	-0.9	-0.6	-0.8
Pain experienced in last month	0.5	0.8	4.0	-0.6	-0.1	-0.5	-0.0	-2.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	-0.6	-0.1	-1.3	-1.3	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	2.5	-0.4	-0.6	0.7	0.6	-1.6	0.1
Breast Cancer	0.4	0.9	3.8	-0.1	0.4	2.0	1.1	-0.3	0.5
Blood Platelet Count	0.4	4.6	17.6	4.2	-1.7	-0.9	0.5	2.4	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	-0.5	-0.6	-1.5	-1.0	0.2	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.0	-1.4	-0.1	0.0	-0.2	-1.0	-0.7
Townsend deprivation index at recruitment	0.4	0.6	1.5	0.4	-0.7	-1.0	-0.6	0.1	-1.2
Age when periods started (menarche)	0.4	1.1	1.6	0.4	-1.3	1.1	-0.9	-1.1	-1.1
Body mass index (BMI)	0.4	1.6	4.5	-0.6	-0.8	-2.1	-1.6	-0.0	-1.1
Number of incorrect matches in round	0.4	0.7	2.5	1.6	-0.4	0.2	-1.0	-0.5	-0.5
Nervous feelings	0.4	0.8	1.9	-0.3	0.4	-1.4	-1.0	1.2	-0.1
Had other major operations	0.4	0.5	1.9	-1.4	-0.7	-0.3	-0.3	-0.1	-0.8
Forced vital capacity (FVC)	0.4	1.5	4.5	2.1	-1.4	0.7	0.5	-0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	-0.4	1.7	0.1	0.7	-0.1	1.2
Illnesses of siblings	0.4	0.5	1.1	-1.0	-0.1	1.1	1.0	-0.4	-0.0
Impedance of arm (right)	0.4	1.8	5.3	-0.5	0.1	2.3	2.2	-0.1	0.7
Arm fat percentage (right)	0.4	1.5	2.5	-1.3	-1.2	-1.6	-1.2	-0.4	-1.3
Worrier / anxious feelings	0.4	0.7	3.2	-0.2	1.8	-0.1	0.1	0.6	0.8
Falls in the last year	0.4	0.6	1.5	-1.2	0.3	-1.0	-0.8	0.6	0.2
Arm fat mass (right)	0.4	1.7	3.5	-0.8	-1.4	-1.9	-1.2	-0.8	-1.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.4	0.4	-0.4	-0.6	-1.0	-1.6	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.8	0.5	-0.4	1.3	0.4	0.8	0.1
Neck or shoulder pain in last month	0.4	0.6	1.4	0.5	-0.9	0.7	-0.7	0.1	-1.2
Whole body fat mass	0.4	1.5	2.2	-1.5	-1.4	-1.4	-0.7	-0.7	-1.3
Leg fat mass (right)	0.4	1.4	2.8	-1.0	-1.3	-1.7	-1.0	-0.5	-1.2
Alcohol intake frequency.	0.4	0.9	1.7	-1.0	0.4	-1.3	-1.3	0.9	-0.4
Comparative height size at age 10	0.4	2.0	6.4	-0.9	-1.6	0.7	0.5	-2.5	-1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	-0.3	-0.4	1.1	0.4	-1.0	-0.6
Loneliness, isolation	0.4	0.5	1.3	0.5	1.1	-0.5	0.4	1.1	0.5
Qualifications: nursing, teaching	0.4	0.6	2.7	-0.4	-0.5	-0.6	-1.6	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.3	-0.3	-1.1	-0.8	-0.2	0.1	-0.8
Back pain experienced in last month	0.4	0.5	0.9	-0.3	-0.9	-0.4	-0.6	0.9	-1.0
Breast cancer (self-reported)	0.4	0.5	1.7	0.4	-1.3	-0.5	-0.4	-0.4	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	-0.7	0.3	1.1	1.0	0.3	0.3
Leg fat percentage (left)	0.4	1.3	3.4	-1.1	-1.1	-1.9	-1.1	0.2	-1.0
Diastolic blood pressure, automated reading	0.4	1.1	5.5	-2.4	0.8	-0.5	-0.5	0.3	0.3
Alcohol drinker status: Previous	0.4	0.4	1.1	0.9	0.4	0.1	-1.1	-0.6	-0.4
Arm predicted mass (left)	0.4	1.9	2.9	-0.2	-1.3	-1.6	-1.2	-1.7	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.2	0.2	-0.5	-1.8	-0.9	-0.5	-0.6
Mean Putamen Volume	0.3	0.3	1.0	-0.4	0.4	0.3	-0.5	-1.0	-0.2
Neuroticism (2016)	0.3	0.5	1.5	1.2	0.6	-0.8	-0.2	0.1	0.4
Blood Red Count	0.3	3.1	6.8	-2.6	-1.7	-0.9	-1.3	-2.1	-1.4
Height	0.3	5.3	15.1	-0.7	-1.9	2.2	2.2	-3.9	-1.7
Hand grip strength (left)	0.3	0.7	2.3	0.6	0.2	1.2	1.5	-0.5	0.3
Pack years adult smoking proportion	0.3	0.4	0.7	0.7	0.7	0.3	0.9	0.1	0.8
Hand grip strength (right)	0.3	0.8	2.4	1.6	-0.2	0.7	1.4	0.0	0.3
Supplements: Glucosamine	0.3	0.4	1.5	1.2	0.4	0.8	-0.0	-0.2	0.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.6	0.5	-0.7	-0.9	-0.3	0.3
Trunk fat mass	0.3	1.1	2.1	-1.1	-1.5	-1.1	-0.4	-0.7	-1.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.9	0.5	1.0	-0.1	0.3	0.8	0.8
Diabetes (self-reported)	0.3	0.4	1.2	-0.7	0.4	-0.6	0.4	1.1	0.5
Hip circumference	0.3	1.2	3.8	-0.4	-1.1	-2.0	-0.9	-0.4	-1.0
Father’s age at death	0.3	0.4	0.6	-0.5	0.7	0.7	0.5	-0.7	0.3
Noisy workplace	0.3	0.4	0.8	0.4	-0.8	-0.9	0.5	0.6	-0.2
Tense / ‘highly strung’	0.3	0.4	1.4	0.2	0.1	-0.4	-0.5	-1.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	0.9	1.2	-0.7	-0.1	0.4	0.6
Hair/balding pattern: Pattern 4	0.3	0.7	3.6	-1.9	0.2	0.1	-0.2	0.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.4	0.2	-0.3	1.6	0.7	-0.1	-0.3
Gout (self-reported)	0.3	0.4	1.8	-0.2	-0.2	0.4	0.1	-1.3	-0.5
Body fat percentage	0.3	1.1	2.1	-1.4	-1.3	-1.2	-0.6	-0.0	-1.0
Leg fat percentage (right)	0.3	1.3	3.3	-1.0	-1.0	-1.8	-1.1	0.1	-1.0
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.3	1.1	0.5	0.8	0.1	0.6
Worry too long after embarrassment	0.3	0.5	1.1	-0.3	-0.1	-0.7	-1.1	-0.6	-1.0
Arm fat mass (left)	0.3	1.2	2.2	-0.5	-1.2	-1.5	-1.0	-0.8	-1.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.8	0.9	-0.7	-0.0	-0.4	0.5	-0.5
Arm fat-free mass (left)	0.3	1.3	2.4	0.1	-1.0	-1.6	-0.9	-1.2	-1.4
Impedance of whole body	0.3	1.5	4.2	-0.6	-0.2	2.1	2.0	0.3	0.7
Leg fat mass (left)	0.3	1.1	2.3	-0.9	-1.2	-1.5	-0.9	-0.4	-1.1
Bipolar Disorder (2018)	0.2	0.3	0.5	0.7	-0.3	-0.5	-0.6	0.6	-0.3
Depression (Nagel 2018)	0.2	0.2	0.5	-0.6	-0.2	0.1	-0.4	-0.7	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.4	-0.7	-0.2	-0.3	-1.2	-0.5	-1.0
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	0.5	-0.7	-1.0	-0.4	-0.3
Alzheimer’s Disease (in father)	0.2	0.3	1.1	-0.1	0.0	0.2	0.5	-1.1	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.2	0.3	-0.0	-1.5	0.5	-0.1	0.5
Age at First Birth	0.2	0.3	1.0	-0.4	-0.2	-0.5	-0.6	-1.0	-0.2
Rheumatoid Arthritis	0.2	0.3	0.8	0.7	-0.3	-0.7	-0.5	0.9	-0.0
Allergy or Eczema	0.2	0.6	2.5	-1.6	-0.1	-0.7	-0.7	0.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	-0.4	0.7	-0.6	-0.4	0.3	0.4
Systolic blood pressure, automated reading	0.2	0.6	3.1	0.2	-0.1	-1.8	-0.6	-0.6	-0.1
Angina	0.2	0.3	1.3	-0.3	0.1	-1.1	-0.7	0.2	0.1
Diabetes (father)	0.2	0.3	0.9	0.1	-0.5	0.9	-0.0	-0.6	-0.5
Trunk fat percentage	0.2	0.8	1.8	-1.2	-1.3	-0.8	-0.1	-0.1	-0.9
Average weekly fortified wine intake	0.2	0.2	1.0	-1.0	0.0	0.5	-0.2	-0.3	-0.3
Relative age voice broke	0.2	0.3	0.7	-0.8	0.7	0.3	0.5	0.4	0.5
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.6	-0.6	0.6	0.5	-0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-1.0	0.2	-0.6	-0.9	0.7	0.0
Alcohol usually taken with meals	0.2	0.2	1.0	1.0	0.1	-0.1	-0.6	0.2	0.0
Medication: Ramipril	0.2	0.2	0.8	-0.0	0.4	-0.2	0.6	0.9	0.3
Weight	0.2	1.2	2.0	-0.8	-1.2	-1.4	-0.7	-1.0	-1.3
Trunk fat-free mass	0.2	1.3	3.5	0.3	-0.7	-1.1	-0.7	-1.9	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	0.2	0.2	-1.0	-0.5	0.6	0.2
Pulse rate	0.2	0.3	1.2	0.2	0.8	1.1	-0.0	0.1	-0.1
Trunk predicted mass	0.2	1.2	3.3	0.2	-0.7	-1.1	-0.7	-1.8	-1.4
Standing height	0.2	2.3	6.0	-0.3	-1.1	1.4	1.9	-2.4	-0.9
Loud music exposure frequency	0.2	0.3	0.8	0.4	-0.2	0.7	0.9	0.2	0.1
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.3	0.1	-0.9	-0.9	0.1	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	-0.6	-0.4	-0.1	-0.5	-0.1	-0.8
Arm fat-free mass (right)	0.2	1.0	1.4	0.3	-0.9	-1.2	-0.9	-1.2	-1.2
Health satisfaction	0.2	0.2	1.1	1.1	0.3	-0.2	-0.4	0.1	0.0
Angina (self-reported)	0.2	0.3	1.1	-0.4	-0.1	-1.1	-0.8	0.1	-0.0
Arm predicted mass (right)	0.2	1.1	1.8	0.5	-1.0	-1.4	-0.9	-1.2	-1.3
Whole body fat-free mass	0.2	1.0	2.5	0.2	-0.7	-1.0	-0.6	-1.6	-1.2
Arm fat percentage (left)	0.2	0.8	1.5	-0.9	-0.9	-1.2	-0.8	-0.1	-0.9
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.0	0.2	-0.9	-0.4	0.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.4	0.0	-0.9	0.2	-0.3	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.5	0.9	-0.3	-0.2	0.3	0.5
Mineral and other dietary supplements	0.2	0.3	0.8	0.1	-0.7	-0.9	0.3	0.3	-0.6
Whole body water mass	0.2	1.0	2.7	0.1	-0.8	-0.9	-0.5	-1.6	-1.3
Miserableness	0.2	0.4	1.1	-1.1	-0.5	-0.0	0.0	-0.5	-0.8
Hearing aid user	0.2	0.2	0.6	-0.1	0.4	0.5	0.6	0.1	0.8
Basal metabolic rate	0.2	1.0	2.4	-0.0	-0.8	-0.9	-0.5	-1.6	-1.3
Unable to work because of sickness or disability	0.2	0.3	1.0	1.0	-0.1	0.6	0.4	-0.0	0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.6	-0.4	-0.4	-0.4	-0.7	-0.2	-0.8
HDL Cholesterol	0.1	0.2	0.7	0.4	-0.3	0.8	-0.0	-0.2	-0.2
Impedance of leg (right)	0.1	0.5	1.4	-0.5	-0.5	1.2	1.1	-0.1	0.2
Leg fat-free mass (left)	0.1	0.3	1.1	0.2	-0.3	-0.4	0.1	-1.1	-0.6
High blood pressure (mother)	0.1	0.1	0.5	-0.0	0.7	0.1	0.1	0.2	0.4
Impedance of leg (left)	0.1	0.6	1.3	-1.0	-1.1	0.9	0.6	-0.2	-0.3
Leg predicted mass (left)	0.1	0.3	1.1	0.2	-0.2	-0.3	0.1	-1.1	-0.6
Qualifications: None of the above	0.1	0.3	0.8	0.9	0.1	-0.8	0.2	0.3	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.6	0.2	-0.4	0.2	-0.0	-0.3
Neuroticism score	0.1	0.2	0.6	0.1	0.3	-0.8	-0.2	0.4	-0.3
Medication: Allopurinol	0.1	0.1	0.8	0.9	-0.0	0.1	0.1	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.4	0.6	0.0	0.5	0.1	0.3
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.1	0.3	-0.8	-0.4	0.2	-0.1
Leg fat-free mass (right)	0.1	0.5	1.5	-0.1	-0.6	-0.5	-0.2	-1.2	-0.9
Ever had bowel cancer screening	0.1	0.2	0.8	-0.9	0.1	0.0	-0.1	-0.4	-0.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.3	0.1	-0.7	0.1	0.7	0.1
Leg predicted mass (right)	0.1	0.5	1.5	-0.1	-0.6	-0.5	-0.3	-1.2	-1.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.3	0.2	0.7	-0.6	-0.4	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.5	0.7	0.3	0.1	0.4	-0.5	0.1
Systolic Blood Pressure	0.0	0.2	0.8	-0.2	0.9	-0.3	0.1	-0.4	0.6
Hair Pigment	0.0	0.3	0.8	0.1	0.1	-0.9	-0.6	0.6	0.3
Tanning	0.0	0.6	3.1	1.8	0.2	0.2	-0.2	-0.6	0.2
Qualifications: College or University degree	0.0	0.1	0.2	0.3	-0.1	0.5	-0.1	0.3	0.5
Ever depressed for a whole week	0.0	0.0	0.1	-0.2	-0.2	0.1	0.0	-0.3	-0.2

Hub : Genes

ZUFSP

Models

Trait associations