Best TWAS P=3.04e-16 · Best GWAS P=1.56e-15 conditioned to 0.00171
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EIF3E | 0.07 | 0.07 | bslmm | 401 | 0.09 | 1.5e-11 | -6.9 | 8.1 | 3.8e-16 | 0.75 | 0.83 | 0.17 | FALSE |
| 2 | GTEx | Brain Cerebellum | EIF3E | 0.16 | 0.04 | lasso | 9 | 0.10 | 7.9e-04 | 7.1 | 6.2 | 6.7e-10 | 0.52 | 0.09 | 0.34 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | EMC2 | 0.09 | 0.10 | enet | 13 | 0.03 | 2.2e-02 | 6.5 | -6.7 | 2.2e-11 | -0.85 | 0.10 | 0.64 | FALSE |
| 4 | GTEx | Muscle Skeletal | EMC2 | 0.05 | 0.04 | lasso | 3 | 0.02 | 2.7e-03 | 7.3 | 7.3 | 2.1e-13 | 0.93 | 0.19 | 0.74 | FALSE |
| 5 | GTEx | Testis | EMC2 | 0.28 | 0.06 | enet | 70 | 0.03 | 2.3e-02 | -6.2 | 6.8 | 7.9e-12 | 0.52 | 0.11 | 0.58 | FALSE |
| 6 | YFS | Blood | EIF3E | 0.01 | 0.00 | blup | 452 | 0.01 | 1.4e-04 | -6.9 | 8.2 | 3.0e-16 | 0.70 | 0.21 | 0.68 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | EIF3E | 0.02 | 0.01 | blup | 38 | 0.01 | 6.0e-02 | -6.9 | 7.7 | 1.8e-14 | 0.65 | 0.09 | 0.36 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF3E | 0.02 | 0.02 | blup | 38 | 0.01 | 1.5e-02 | -6.9 | 6.1 | 8.6e-10 | 0.69 | 0.10 | 0.24 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TTC35 | 0.04 | 0.02 | blup | 52 | 0.03 | 2.8e-04 | 7.4 | 5.6 | 1.8e-08 | 0.84 | 0.05 | 0.87 | FALSE |