Hub : Genes

CD53

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1240	0.0300	2.2e-08	0.090	0.080	0.097	0.097	0.107	5.1e-11	5.7e-10	7.3e-12	7.5e-12	6.5e-13
2	GTEx	Brain Cortex	0.3470	0.1000	2.0e-04	0.045	NA	0.034	NA	0.123	2.2e-02	NA	4.0e-02	NA	2.9e-04
3	GTEx	Liver	0.6500	0.1190	5.4e-04	-0.010	NA	-0.011	NA	0.099	8.7e-01	NA	9.9e-01	NA	1.0e-03
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1560	0.0560	3.8e-03	-0.005	NA	0.017	NA	0.004	8.5e-01	NA	3.6e-02	NA	1.8e-01
5	METSIM	Adipose	0.0377	0.0160	9.5e-03	-0.001	0.008	0.001	0.009	-0.001	6.8e-01	1.7e-02	2.5e-01	1.5e-02	6.5e-01
6	NTR	Blood	0.0298	0.0107	9.0e-04	0.002	0.006	0.001	0.006	0.001	8.8e-02	3.0e-03	1.5e-01	2.6e-03	1.7e-01
7	ROSMAP	Brain Pre-frontal Cortex	0.2160	0.0366	0.0e+00	0.201	0.174	0.228	0.217	0.236	3.0e-25	8.6e-22	8.0e-29	2.3e-27	6.7e-30
8	YFS	Blood	0.0331	0.0119	5.8e-04	0.016	0.008	0.006	NA	0.003	3.7e-06	8.8e-04	3.0e-03	NA	3.4e-02
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0453	0.0269	4.4e-03	0.024	0.008	0.001	NA	0.009	9.0e-04	3.6e-02	2.6e-01	NA	3.0e-02
10	TCGA	Brain Lower Grade Glioma	0.0686	0.0316	4.9e-05	0.016	0.042	0.030	NA	0.021	5.0e-03	1.3e-05	2.2e-04	NA	1.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.2	4.0	-1.6	-1.1	0.2	-0.6	2.0	0.2	-1.4	-0.2	0.9	-0.9
Bipolar Disorder or Schizophrenia	0.7	1.7	4.1	-1.6	-1.2	0.2	0.4	2.0	1.0	-1.5	1.7	1.2	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	1.7	0.6	0.5	0.6	-0.0	-0.7	0.2	0.5	0.2	-0.8	1.3
Depression (Nagel 2018)	1.3	1.9	6.0	2.3	1.5	0.1	-0.5	-0.6	0.2	2.5	-0.4	-1.7	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.5	-0.7	-0.6	-0.1	0.7	0.0	1.2	-0.5	-0.0	-0.7	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.5	0.8	1.2	-0.8	0.0	0.3	0.3	0.8	1.0	-0.5	0.7
Schizophrenia (2018)	0.5	1.1	5.4	-0.7	-0.6	-0.1	1.0	1.0	1.1	-0.8	2.3	0.8	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	1.5	-0.0	-0.9	0.8	1.2	0.1	-0.1	-0.3	0.8	-0.3	-0.6
Worry (Nagel 2018)	0.4	0.8	3.0	0.6	0.9	-1.4	-0.7	-0.1	0.4	0.8	1.7	-0.6	-0.2
Alzheimer’s Disease (in mother)	0.8	1.0	7.2	0.3	-0.6	2.7	-0.6	-0.2	1.2	0.0	-0.2	0.1	0.0
Alzheimer’s Disease (in father)	0.8	0.9	3.0	-0.2	-0.0	1.4	1.7	0.2	-0.8	-0.0	0.9	0.9	-1.2
Alzheimer’s Disease (including proxy)	1.2	1.8	9.4	-0.9	-1.4	3.1	1.0	0.9	1.0	-0.9	0.7	1.0	-0.9
Crohns Disease (2017)	0.3	0.6	1.8	-0.9	-0.3	-0.2	0.9	1.3	0.0	-0.7	1.3	-0.1	-0.2
Irritable Bowel Disease (IBD)	1.1	2.6	7.2	-2.7	-2.3	0.5	-0.0	1.9	0.2	-2.5	1.5	0.6	-0.7
Ulcerative Colitis (UC)	2.2	4.0	10.5	-3.2	-3.2	1.0	-0.9	2.1	0.2	-3.2	1.2	0.9	-0.8
Major Depression (MDD)	0.4	0.4	1.1	0.8	0.6	0.3	-0.1	0.9	-0.0	0.8	-0.0	-1.0	0.7
Reaction Time	1.3	2.5	9.5	-2.1	-3.1	1.0	1.2	0.2	0.4	-2.0	-0.1	1.1	-1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	3.2	0.0	-0.2	-0.1	0.2	-0.8	1.8	0.1	-0.4	-1.1	0.4
Breast Cancer	1.0	2.4	4.0	2.0	1.6	-1.6	0.8	-1.2	-1.6	1.9	-1.4	-1.2	2.0
Ovarian Cancer	0.5	0.7	2.1	-1.0	0.4	-0.2	0.5	0.7	1.4	-0.8	1.4	0.6	0.1
Prostate Cancer	2.3	3.2	6.2	2.3	1.4	-2.5	0.1	-2.0	-1.8	2.2	-1.5	-1.3	1.7
Age at First Birth	1.1	1.7	5.7	-2.4	-1.2	0.7	-0.7	-0.3	-1.1	-2.0	-0.6	-1.4	-0.7
Bipolar Disorder (2011)	1.6	1.5	4.3	-2.1	-1.9	0.2	1.2	1.1	0.4	-1.9	0.1	0.5	-0.8
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	0.6	1.1	-1.5	0.9	-0.5	0.0	0.4	0.1	0.4	0.7
Coronary Artery Disease (CAD)	1.5	1.7	5.4	-1.5	-2.0	0.9	-0.4	2.3	0.8	-1.0	0.5	0.5	-1.6
Crohns Disease (2012)	0.4	0.6	2.9	0.6	1.0	-0.3	0.5	1.7	-0.3	0.9	0.3	-0.7	0.2
Mean Putamen Volume	0.3	0.3	1.1	0.1	-0.5	0.3	1.0	0.8	0.6	-0.1	-0.4	0.6	-0.2
Fasting Glucose	2.1	2.5	7.0	-1.8	-0.8	0.0	0.8	1.9	1.0	-1.7	1.4	2.0	-2.6
HbA1C	0.7	0.8	2.4	-0.6	-1.4	-1.5	-1.0	0.8	0.5	-0.7	-0.9	0.4	-0.2
HDL Cholesterol	0.6	1.1	3.5	-0.3	0.2	0.4	-0.2	-0.7	-1.7	-0.2	-1.9	-1.8	0.1
LDL Cholesterol	0.4	0.6	1.7	0.2	1.3	0.4	0.6	0.5	0.4	0.7	0.4	0.9	-1.2
Lupus	0.5	0.8	2.1	-0.6	-0.2	-1.2	-0.5	-1.4	-0.8	-0.6	-1.1	-1.2	-0.7
Neuroticism (2016)	0.3	0.4	1.3	0.0	-0.1	0.2	-0.4	0.7	1.0	0.0	1.1	-0.0	1.1
Primary Biliary Cirrhosis	0.9	1.3	4.3	-1.7	-0.5	-0.6	-1.2	-0.4	0.6	-1.5	0.3	-2.1	0.9
Rheumatoid Arthritis	1.4	1.9	7.4	-0.0	0.3	-1.3	-2.0	2.7	1.8	0.1	0.3	-0.9	1.5
Schizophrenia (2014)	1.1	2.4	4.2	-1.8	-1.5	0.1	1.3	1.7	1.4	-1.8	2.0	1.4	-1.6
Triglycerides	0.8	1.4	3.9	0.9	2.0	-0.6	0.9	0.1	1.1	1.3	1.6	1.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	1.0	0.7	-0.7	-0.3	-1.2	-0.2	1.3	-0.1	-0.2	0.8
Ulcerative Colitis	1.1	1.6	4.9	-1.6	-1.9	0.4	-1.3	2.2	0.5	-1.5	0.7	0.2	0.2
Blood Eosinophil Count	1.8	13.6	25.6	2.9	3.2	-1.2	-4.2	-2.3	-4.8	2.8	-4.3	-5.1	4.3
Blood Platelet Count	0.5	5.6	42.8	0.1	-0.2	-0.6	-6.5	-1.0	0.1	0.0	0.4	-1.9	2.8
Blood Red Count	0.1	1.2	4.2	1.2	1.4	-0.6	0.6	-2.1	-0.0	1.1	-0.0	-0.8	1.3
Blood White Count	0.2	1.8	6.8	-0.1	0.3	-0.5	-2.6	0.0	-1.5	-0.2	-0.9	-2.0	2.0
Heel T-Score	0.0	0.2	0.6	-0.1	0.2	0.7	-0.4	0.2	0.1	-0.1	-0.8	-0.5	0.4
BMI	0.8	4.8	8.9	2.6	2.4	-0.9	2.2	-2.0	-3.0	2.4	-2.0	-1.9	1.9
Height	0.1	1.8	11.8	-1.1	-0.1	-3.4	-1.6	-0.1	0.4	-1.0	0.2	-0.7	0.7
Waist Hip Ratio (WHR)	0.1	0.7	1.8	0.7	0.8	-0.5	-1.1	-0.3	0.5	0.4	1.0	-1.4	0.9
Systolic Blood Pressure	0.4	2.0	5.7	1.1	0.5	-2.4	-0.5	-0.2	-2.0	1.1	-2.0	-1.1	1.3
Smoking Status	0.2	0.5	1.8	-0.5	-0.5	0.4	-1.3	1.1	0.4	-0.5	0.7	-0.6	0.1
Allergy or Eczema	0.2	0.5	1.2	-0.4	-1.1	0.7	0.2	0.6	-0.2	-0.5	-1.0	0.9	-0.7
Cardiovascular Disease	1.2	4.0	8.5	2.9	2.8	0.6	-2.6	0.3	-2.4	2.7	-0.1	-0.5	1.7
Hypothyroidism (self reported)	1.3	3.0	9.2	0.5	1.4	-1.4	0.4	0.6	-3.0	0.5	-2.2	-2.3	2.4
Respiratory disease	0.6	1.4	4.3	1.2	0.4	0.5	-0.6	-1.6	-0.5	1.2	-1.3	-2.1	1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.0	8.0	1.4	1.2	-0.4	1.2	-1.0	-1.7	1.3	-0.2	-1.1	2.8
Lung FEV1/FVC ratio	1.3	6.5	52.9	-0.2	0.8	-1.2	7.3	2.4	0.6	-0.0	0.2	1.1	-1.6
Lung FVC	0.2	1.2	2.4	-1.3	-1.4	0.1	1.4	0.5	-0.5	-1.3	-1.3	0.2	-1.6
Neuroticism	0.3	0.7	1.9	0.7	1.2	-0.6	-0.4	-0.1	0.1	0.7	1.1	-1.1	1.4
Chronotype (morning person)	0.2	0.5	1.7	-0.9	-0.6	0.7	-1.3	0.5	0.2	-0.7	-0.1	0.4	-0.9
Hair Pigment	0.1	2.0	5.1	-2.2	-2.1	0.8	-0.3	0.0	2.0	-1.9	1.0	0.7	0.1
Tanning	0.1	1.0	5.4	0.7	0.8	-2.3	0.3	1.0	-0.2	0.5	1.0	-0.3	0.9
Hand grip strength (left)	0.2	0.5	1.5	-1.1	-0.0	0.6	0.2	0.3	-0.6	-1.2	-0.7	0.5	-0.6
Number of treatments/medications taken	1.2	2.1	7.5	0.6	1.8	-1.0	1.1	-1.3	-2.7	0.7	-1.1	-2.1	0.5
Average weekly spirits intake	0.6	0.8	2.0	0.7	1.1	-0.9	0.5	-1.4	-0.7	1.4	-0.3	-0.1	-0.5
Sensitivity / hurt feelings	0.3	0.5	1.7	-0.0	0.8	-1.1	-0.1	1.0	-1.3	-0.1	0.4	0.2	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	1.1	0.5	-0.1	0.9	-0.2	0.9	1.1	0.4	-0.4	0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.5	-1.2	-0.5	-0.3	-0.9	0.7	-0.6	-1.2	0.7	-0.2	-0.9
Relative age of first facial hair	0.1	0.3	1.1	-0.5	-0.5	0.6	0.4	-0.0	1.1	-0.3	0.9	0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.3	-0.2	0.6	-0.1	-0.9	-0.8	-0.2	-0.8	-1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.5	-0.9	-0.1	-0.3	0.6	0.6	1.0	-1.2	1.2	1.0	0.6
Ever had hysterectomy (womb removed)	1.3	1.5	3.9	0.4	1.6	-0.9	-0.3	-1.9	-0.9	0.4	-0.2	-1.7	2.0
Systolic blood pressure, automated reading	0.2	0.5	1.9	0.8	0.2	-0.6	0.2	-0.6	-1.2	0.5	-1.4	-0.1	0.7
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.5	-1.1	0.0	-0.1	0.5	1.7	-2.1	-1.1	-1.3	-1.0	0.5
Angina	1.4	1.8	4.2	1.5	2.0	-0.2	-0.5	-0.3	-0.8	1.5	-1.1	-2.0	1.9
Medication for hormone replacement therapy	0.6	0.7	2.3	-0.8	0.1	-0.2	0.3	0.5	1.1	-1.0	1.3	1.5	-0.3
Vitamin and mineral supplements	1.3	1.8	4.0	1.9	0.3	1.0	-1.7	-1.0	-1.0	1.8	-0.3	-0.8	2.0
Supplements: Zinc	0.4	0.4	1.8	-0.2	-0.3	-1.0	0.6	-0.3	-0.6	-0.2	-1.3	-0.4	-0.2
Medication: Co-codamol	1.2	1.4	4.6	-0.1	0.5	-1.3	-1.4	2.1	-0.1	0.0	2.1	0.4	-0.6
Medication: Metformin	0.5	0.7	2.5	-0.3	0.5	-0.2	0.5	-0.6	-1.3	-0.3	-0.0	-1.6	1.5
Diabetes (father)	1.0	1.2	4.9	-0.1	0.5	-2.2	0.6	1.6	1.1	-0.2	1.5	0.5	0.4
Diabetes (mother)	2.5	3.2	6.7	2.2	2.3	0.1	0.6	-2.6	-1.6	2.4	-0.8	-2.0	1.3
Severe depression (siblings)	1.0	1.1	3.2	0.5	1.8	-1.5	1.2	0.6	0.7	0.8	1.4	-0.3	0.7
Pack years adult smoking proportion	0.8	1.2	2.9	1.6	1.1	0.3	-0.7	-0.7	0.7	1.7	1.0	0.5	1.5
Impedance of leg (right)	0.3	1.6	9.9	0.3	0.4	-0.3	-3.1	1.3	0.8	0.3	1.7	0.5	0.5
Leg fat-free mass (left)	0.2	1.2	2.7	0.9	0.9	-0.4	1.6	-1.3	-1.6	0.6	-1.4	-0.9	0.6
Trunk fat percentage	0.9	3.8	9.4	2.9	3.1	-0.3	0.3	-1.3	-2.1	2.7	-0.4	-1.7	1.8
Hand grip strength (right)	0.4	1.0	5.8	0.3	0.3	-0.3	-0.8	-1.0	-1.2	0.2	-2.4	-0.8	0.6
Townsend deprivation index at recruitment	0.6	0.9	2.9	-0.4	-1.3	1.7	0.2	-0.2	1.2	-0.4	0.2	-0.5	1.4
Current tobacco smoking	0.4	0.7	2.0	1.2	0.1	0.7	-0.5	-0.1	0.8	1.4	-0.3	-0.7	1.2
Average weekly fortified wine intake	0.7	0.8	2.6	-1.5	-1.0	-0.9	0.6	0.3	-0.3	-1.6	-0.1	1.1	-0.1
Maternal smoking around birth	0.5	0.8	3.4	1.0	0.5	0.4	-1.8	0.7	-0.6	1.0	-0.3	-0.5	0.9
Fed-up feelings	0.3	0.5	1.9	0.1	-0.5	1.4	-0.9	0.6	-0.3	0.0	-0.3	-0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	4.4	2.0	0.9	0.8	-0.7	0.7	0.1	2.1	0.1	-1.5	0.9
Relative age voice broke	0.4	0.6	2.1	0.7	0.8	0.7	-0.8	-0.8	0.3	0.8	0.5	-1.4	0.8
Taking other prescription medications	0.8	1.2	5.8	-0.3	0.6	-0.4	1.1	-0.8	-2.4	-0.2	-0.0	-1.8	-0.1
Age when periods started (menarche)	0.4	1.0	3.8	-1.0	0.5	-0.6	0.1	1.9	0.1	-1.1	0.7	1.6	-0.3
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	7.1	0.4	1.6	-0.5	-0.3	-0.8	-0.6	0.2	-0.1	-2.0	2.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	6.1	0.5	0.4	-0.4	0.1	-0.6	-1.5	0.4	-2.5	-0.6	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.7	0.3	1.4	0.6	0.3	0.1	0.3	0.2	1.6	0.8	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.8	-0.9	-0.3	-0.6	-1.1	0.2	0.4	-0.9	1.3	-0.8	0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.1	-1.0	-0.2	0.2	-0.6	1.0	0.0	-1.0	-0.1	0.5	-0.2
High blood pressure	1.0	2.7	6.8	2.6	2.4	-0.2	-0.6	-1.3	-1.9	2.3	-0.7	-0.0	1.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.5	0.2	-0.7	0.4	0.3	0.8	0.2	-0.0	-0.8	1.6	-0.9
Multivitamins +/- minerals	1.2	1.5	3.4	-1.8	0.1	-1.0	1.4	1.3	-0.4	-1.5	-1.0	0.7	-1.8
Stomach or abdominal pain in last month	0.7	0.8	3.7	-0.2	0.8	-1.9	-1.2	-0.6	-0.9	-0.2	0.8	-0.6	0.4
Supplements: Glucosamine	0.2	0.3	1.0	-0.7	0.1	-0.3	0.9	0.6	-0.2	-0.5	-0.2	0.1	-1.0
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	5.7	-0.2	-1.4	0.3	1.2	1.7	2.0	-0.2	0.7	2.4	-0.6
Medication: Atenolol	0.6	0.8	2.4	1.1	1.5	-0.9	0.8	0.5	0.2	1.1	-0.1	0.3	1.0
Medication: Levothyroxine sodium	0.6	1.1	4.1	0.3	0.4	-0.3	0.2	-0.1	-2.0	0.4	-1.6	-1.5	1.1
Sitting height	0.0	0.3	0.7	0.9	0.7	0.1	0.0	-0.8	-0.5	0.8	0.2	-0.1	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	2.1	-0.1	-0.7	0.0	-0.5	-0.3	0.8	0.3	-1.4	-1.5	0.4
High blood pressure (mother)	0.8	1.2	4.3	0.9	1.4	-2.1	0.0	-0.5	-1.5	0.8	-0.3	-0.6	1.0
Body mass index (BMI)	0.8	3.5	5.6	2.4	2.3	0.3	1.7	-1.7	-2.2	2.1	-1.2	-1.8	1.9
Impedance of leg (left)	0.3	1.3	6.1	0.8	0.6	-0.7	-2.5	0.9	0.8	0.8	1.4	0.3	0.9
Leg predicted mass (left)	0.2	1.2	2.6	0.9	0.9	-0.4	1.6	-1.3	-1.6	0.6	-1.3	-0.8	0.6
Trunk fat mass	0.9	4.1	8.6	2.8	2.9	-0.6	0.9	-1.6	-2.3	2.5	-0.8	-2.0	2.1
Waist circumference	0.9	3.3	7.5	1.9	1.6	-0.6	0.7	-1.6	-2.7	1.6	-1.2	-2.6	2.4
Number of incorrect matches in round	1.0	1.6	4.2	-1.8	-1.8	0.4	1.0	0.3	-0.1	-1.6	-0.7	0.5	-2.0
Past tobacco smoking	0.2	0.4	1.7	0.3	0.4	-0.1	1.3	-0.9	0.5	0.4	-0.5	-0.0	0.2
Alcohol usually taken with meals	0.8	1.4	4.2	-1.3	-0.8	-0.1	-2.1	-0.4	-0.6	-1.5	-1.7	-1.1	-0.4
Nervous feelings	0.7	1.4	5.7	-0.6	-0.3	-1.9	0.4	1.5	0.7	-0.6	2.4	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.8	0.6	0.7	-1.2	-0.3	0.9	1.4	0.5	1.9	0.7	0.5
Hearing difficulty/problems with background noise	0.3	0.4	2.4	0.4	0.2	-0.2	0.4	-1.6	-0.9	0.5	-0.5	0.0	-0.3
Hair/balding pattern: Pattern 2	0.8	1.0	4.3	0.7	0.6	-0.2	0.5	0.0	2.1	0.5	1.6	0.8	0.9
Had menopause	0.4	0.5	1.4	-0.1	-0.1	0.2	0.7	-0.3	1.2	-0.3	1.1	1.1	0.3
Had other major operations	0.3	0.3	2.4	0.5	-0.1	-0.2	1.6	0.0	0.1	0.1	-0.6	-0.2	0.4
Forced vital capacity (FVC)	0.1	0.5	1.5	-0.9	-0.8	-0.3	0.4	0.5	0.3	-0.8	-0.8	0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	3.7	0.2	0.0	0.2	0.3	-0.3	-1.8	0.1	-1.9	-0.3	0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.9	-1.0	-0.8	0.4	1.3	0.5	-0.0	-1.0	2.0	0.3	-0.3
Qualifications: None of the above	0.8	1.8	5.5	2.2	1.7	0.9	-1.5	0.0	0.3	2.3	0.4	-0.5	1.2
Financial difficulties in last 2 years	1.6	2.2	5.5	2.4	0.5	0.6	-0.9	-0.8	-1.2	2.0	-1.6	-1.8	1.6
Mouth/teeth dental problems	0.3	0.4	1.8	-0.4	-0.9	-0.7	-0.1	0.2	0.3	-0.4	-1.3	0.4	-0.4
Heart attack	0.9	1.2	4.8	1.2	2.2	0.1	-0.0	-0.5	-0.8	1.2	-0.6	-1.6	0.6
Allergy	0.1	0.3	1.3	-1.0	0.1	-0.3	0.4	0.3	0.1	-0.7	1.1	-0.4	-0.1
Pain all over the body in last month	1.6	1.7	5.6	-0.2	-0.3	0.9	0.7	1.4	2.2	-0.1	2.4	1.4	-1.2
Diabetes (self-reported)	0.7	1.0	3.3	1.0	1.5	0.0	1.8	0.2	-0.6	0.9	0.9	-0.1	1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.1	0.3	-0.3	-0.3	0.1	0.6	-1.5	0.2	-1.4	-0.6	0.4
Medication: Ramipril	2.0	2.6	7.4	-0.3	1.6	0.3	-2.2	0.4	-2.7	-0.2	-1.5	-2.2	1.9
Medication: Simvastatin	1.0	1.5	3.7	1.9	1.6	0.6	-0.7	0.3	-0.3	1.6	-0.2	-1.2	1.9
Fluid intelligence score	0.7	1.4	5.3	0.2	-0.7	-1.0	1.4	-2.3	1.7	0.2	-0.6	-1.2	0.5
Illnesses of siblings	1.0	1.5	3.7	-1.8	-0.6	-0.9	1.2	0.1	0.8	-1.8	-0.0	1.0	-1.9
Neuroticism score	0.4	0.7	2.5	0.4	0.6	-0.8	-0.7	0.5	-0.0	0.3	1.3	-1.2	1.6
Weight	0.6	3.1	5.7	1.9	2.0	-0.8	1.6	-1.7	-2.4	1.6	-1.3	-1.9	1.9
Impedance of arm (right)	0.3	1.6	5.0	0.2	-0.1	-0.6	-2.2	1.1	1.9	0.2	1.9	1.1	-0.8
Arm fat percentage (right)	0.9	3.7	7.9	2.8	2.4	0.2	0.8	-1.9	-1.9	2.6	-1.0	-2.0	2.0
Trunk fat-free mass	0.2	1.3	3.2	-0.2	0.0	-0.5	1.8	-1.7	-1.6	-0.3	-1.4	-1.2	0.9
Hip circumference	0.4	1.7	3.0	1.5	1.1	-0.0	1.0	-1.6	-1.7	1.4	-1.3	-1.2	1.5
Time employed in main current job	0.5	0.6	2.7	-0.4	0.6	0.5	0.7	-1.6	0.9	-0.5	0.8	-0.6	0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.3	0.7	0.7	0.9	1.1	-0.4	-0.4	0.4	0.7	1.0	-0.0
Father’s age at death	1.3	1.7	5.5	-2.2	-2.3	0.3	-0.6	0.6	0.3	-2.3	0.5	-0.6	-0.0
Worrier / anxious feelings	0.9	1.7	9.5	-0.1	0.1	0.3	0.3	0.1	1.9	-0.4	3.1	1.6	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.6	0.7	0.6	0.6	-0.5	0.7	0.4	0.5	1.6	-0.3	0.1
Falls in the last year	0.5	0.6	1.4	-1.0	-0.4	-0.9	1.1	-1.2	-0.2	-0.9	-0.1	-0.4	-0.9
Hair/balding pattern: Pattern 3	0.8	1.2	6.0	-0.2	-1.1	1.4	-0.3	-0.2	-1.4	-0.1	-2.4	-0.8	0.1
Number of live births	1.1	1.5	4.9	2.2	-0.2	1.3	1.6	-0.9	0.7	2.2	-0.2	0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	5.0	-1.2	-0.8	-0.4	2.2	1.5	0.3	-1.1	-0.1	0.7	-1.7
Pulse rate	0.5	0.9	2.1	-1.3	-1.3	-0.6	0.5	0.5	-0.3	-1.3	1.5	0.2	-0.5
Happiness	0.1	0.1	0.2	0.1	-0.3	-0.1	-0.2	0.2	-0.4	0.1	-0.4	-0.3	0.2
Noisy workplace	1.1	1.4	5.1	0.7	2.3	-0.6	0.2	1.1	-2.1	0.8	1.1	0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.2	-0.2	-0.7	-0.0	2.1	-1.9	0.1	-0.3	-1.2	1.3	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	6.2	-0.2	0.5	-1.2	2.5	1.4	-1.0	-0.3	-0.9	0.8	-0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	2.3	-1.5	-1.1	0.2	-0.2	0.8	0.3	-1.4	1.4	0.1	0.3
Asthma	0.6	1.1	2.4	1.2	0.4	0.4	-0.1	-1.4	-1.0	1.1	-1.0	-1.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	3.6	-1.5	-0.4	-0.2	1.2	0.9	0.5	-1.5	1.4	0.8	-1.9
Medication: Cholesterol lowering	0.5	0.8	4.7	1.0	2.2	-0.5	-0.1	0.3	-0.4	1.0	0.7	-0.3	0.5
Depression (self-reported)	0.3	0.3	1.6	-0.4	-0.5	0.2	1.3	0.0	-0.5	-0.3	-0.4	0.1	-0.8
Medication: Lansoprazole	1.2	1.4	5.7	0.9	0.6	0.2	-0.4	2.4	-0.9	0.7	1.5	-0.0	1.7
Prospective memory result	0.6	0.7	2.5	0.6	0.7	-0.3	-0.5	1.3	0.9	0.5	1.6	0.9	0.2
Lung cancer (father)	0.6	0.7	4.0	0.0	-0.1	0.5	-0.7	2.0	-1.0	-0.1	-0.3	0.4	-0.9
Illnesses of mother	0.6	0.7	2.7	-1.2	-0.8	-0.9	0.5	0.5	0.1	-1.2	-0.2	0.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	7.3	-1.1	-0.4	-1.1	2.7	1.5	-0.3	-0.9	-0.5	0.2	-1.5
Pulse wave Arterial Stiffness index	0.4	0.5	2.2	-0.0	0.5	-1.0	-0.8	1.5	-0.2	0.0	0.8	0.3	-0.0
Impedance of arm (left)	0.4	1.7	5.5	0.2	-0.2	-0.5	-2.3	0.9	2.3	0.3	1.7	1.0	-0.9
Arm fat mass (right)	0.7	3.1	5.6	2.4	2.2	-0.1	1.5	-1.8	-1.7	2.1	-0.8	-1.7	1.9
Trunk predicted mass	0.2	1.4	3.3	-0.1	0.1	-0.6	1.8	-1.8	-1.5	-0.2	-1.4	-1.2	1.0
Standing height	0.1	0.6	4.9	-0.2	0.1	-2.2	-0.0	-0.7	-0.4	-0.3	-0.2	-0.5	0.4
Length of working week for main job	0.6	0.6	4.5	0.3	-0.4	0.9	0.4	0.4	0.5	0.0	0.2	2.1	0.5
Exposure to tobacco smoke at home	0.5	0.5	1.4	0.2	0.9	-0.5	-0.1	1.1	-1.2	-0.0	-1.1	-0.6	0.4
Breastfed as a baby	0.5	0.6	1.5	-0.7	-0.6	1.2	-1.1	0.3	0.7	-0.7	-0.1	1.0	0.8
Tense / ‘highly strung’	0.3	0.4	1.7	-0.4	-0.3	-0.6	-1.3	0.0	0.4	-0.2	1.3	-0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	7.5	-1.6	-2.7	0.5	0.8	1.4	1.1	-1.7	0.7	0.6	-0.2
Hair/balding pattern: Pattern 4	0.2	0.4	2.0	0.3	0.1	-0.7	1.0	0.4	0.4	0.3	0.7	1.4	-0.2
Birth weight of first child	0.4	0.7	3.2	-0.2	-0.3	-0.2	1.1	0.3	1.8	-0.3	1.0	0.9	0.3
Peak expiratory flow (PEF)	0.6	1.4	6.4	0.4	0.8	-0.8	1.8	2.5	-0.3	0.7	0.4	0.7	-1.3
Pulse wave reflection index	0.4	0.6	4.0	-0.3	-0.8	0.1	-0.5	2.0	0.0	-0.3	0.1	0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.6	0.2	0.4	1.0	0.4	-0.6	-0.3	-0.0	1.6	0.5	-0.5
Loud music exposure frequency	1.2	1.3	3.0	1.1	0.5	1.5	0.2	-1.7	1.6	1.2	-0.1	0.5	1.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.7	-1.6	-1.3	-1.0	1.0	-0.9	-0.6	-1.9	-0.1	1.3	-1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	0.7	0.8	0.4	-0.4	-0.8	-0.2	0.5	0.5	-1.3	0.2
Blood clot in the leg (DVT)	0.4	0.6	2.9	0.8	0.6	-1.7	-0.1	-0.6	1.1	0.4	-0.4	-0.1	0.0
Medication: Paracetamol	0.6	1.0	5.6	-0.0	-0.4	0.9	2.4	-0.2	-0.5	0.2	1.0	0.9	-1.3
Headache pain in last month	0.5	0.9	4.6	-0.3	-0.4	0.7	-0.6	-1.2	-2.1	-0.3	-0.6	-1.0	0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	-0.1	-1.6	-0.1	0.6	1.0	1.7	-0.3	0.2	1.6	-0.9
Glaucoma (self-reported)	0.9	1.1	3.3	-0.5	-1.4	-0.8	1.0	-1.1	-1.2	-0.5	-1.8	-0.8	0.2
Gout (self-reported)	0.5	0.7	2.6	0.4	1.6	-1.4	1.0	-1.1	-0.4	0.5	0.2	-0.6	-0.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.1	0.3	0.5	-0.4	0.9	0.8	-2.0	0.3	-1.5	-1.7	1.5
Medication: Amlodipine	1.1	1.5	5.0	1.6	1.5	-0.1	2.2	-1.4	0.9	1.5	0.2	0.4	-0.3
Medication: Ventolin 100micrograms inhaler	1.6	2.0	3.9	1.9	0.5	0.3	-1.3	-2.0	-1.6	1.8	-1.1	-1.3	1.2
Birth weight	1.4	3.0	9.9	-3.0	-2.6	0.7	0.6	0.3	0.5	-3.1	0.2	0.7	-1.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.0	0.0	0.2	0.5	0.8	0.8	0.3	-0.2	1.0	-0.3	0.3
High blood pressure (siblings)	1.8	2.5	7.9	2.8	1.5	-0.0	-1.0	-0.4	-1.2	2.8	0.1	-1.2	1.9
Forced vital capacity (FVC), Best measure	0.3	0.9	2.2	-1.1	-0.7	-1.0	1.2	0.8	-0.5	-1.0	-0.9	0.0	-1.5
Body fat percentage	1.1	4.5	9.6	3.1	3.0	-0.1	0.4	-1.7	-2.4	2.8	-0.8	-2.1	2.3
Leg fat percentage (right)	1.3	4.7	8.8	3.0	3.0	-0.1	0.0	-1.2	-2.9	2.6	-0.9	-2.1	2.7
Arm fat-free mass (right)	0.3	1.8	4.5	0.9	1.0	-0.9	1.5	-1.6	-2.1	0.7	-1.6	-1.1	1.3
Exposure to tobacco smoke outside home	0.5	0.7	1.3	1.1	0.5	-0.7	0.4	-1.1	-0.5	0.9	-1.0	-0.3	1.0
Comparative body size at age 10	0.3	0.7	2.4	0.3	0.1	0.2	0.1	-1.5	-0.6	0.0	-1.3	-0.7	1.5
Number of full brothers	1.5	1.9	7.7	2.6	1.6	0.1	-0.4	-0.1	-0.7	2.8	0.6	-0.8	0.7
Worry too long after embarrassment	0.3	0.5	1.8	-0.3	0.7	-1.2	-0.3	1.3	0.5	-0.1	0.9	0.2	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.3	-1.0	1.0	0.6	1.2	-0.1	-0.4	0.2	-0.2	-0.2
Wheeze or whistling in the chest in last year	1.4	2.5	7.1	1.1	1.5	-1.0	-1.3	-0.1	-2.7	1.0	-0.6	-2.5	2.1
Number of children fathered	1.1	1.3	5.5	0.3	1.7	-2.3	-0.5	0.2	-1.2	0.7	0.3	-1.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	5.1	-1.2	0.3	-0.5	-1.0	1.1	1.3	-1.1	1.5	2.2	-1.4
Age at first live birth	0.1	0.3	1.0	0.4	0.7	-0.5	-0.5	0.2	-0.3	0.5	0.0	-1.0	0.2
Pulse wave peak to peak time	0.4	0.5	2.6	-0.2	-0.5	0.8	0.7	-1.6	0.4	-0.2	-0.7	-0.4	0.0
Health satisfaction	1.4	1.8	4.2	-1.6	-0.8	0.5	0.8	1.4	0.0	-1.6	2.0	1.4	-1.9
Shortness of breath walking on level ground	0.7	0.8	2.1	0.6	1.1	-0.3	-0.8	-0.6	-1.3	0.7	0.1	-1.2	1.4
Qualifications: College or University degree	0.8	2.6	6.4	-0.1	-0.3	1.4	2.4	-1.8	1.8	0.1	-1.2	2.1	-2.5
Eye problems/disorders: None of the above	1.5	1.8	10.9	0.9	0.0	1.0	-3.3	0.1	-0.8	1.1	-0.1	-1.3	1.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	4.5	-0.0	0.0	2.1	-0.2	-0.1	0.1	-0.1	0.3	1.1	0.2
Emphysema/chronic bronchitis	0.6	0.7	1.7	1.2	0.9	0.2	-1.0	0.1	0.8	1.3	0.8	0.3	0.8
Medication for pain relief, constipation, heartburn	0.7	1.2	5.7	-0.4	-1.1	0.1	-2.4	1.2	1.4	-0.5	-0.2	0.0	1.3
Neck or shoulder pain in last month	0.9	1.2	3.5	-1.4	-1.2	-0.4	-0.6	0.7	-1.9	-1.5	0.1	0.0	-1.5
Medication: Blood pressure	0.5	0.9	2.7	0.1	1.7	0.4	-0.8	-0.8	-1.1	0.2	-0.3	-1.5	1.2
Angina (self-reported)	1.4	1.9	4.2	1.7	2.0	-0.2	-0.3	-0.2	-0.8	1.8	-1.0	-1.7	1.9
Migraine (self-reported)	0.8	0.9	2.6	0.5	1.3	-0.1	0.8	-1.3	-1.2	0.4	0.8	-0.6	1.6
Medication: Ibuprofen	0.9	1.1	4.0	-2.0	-0.9	0.2	0.2	0.6	-0.3	-2.0	0.6	-0.1	-1.2
Medication: Allopurinol	0.3	0.4	1.6	0.7	1.3	-0.1	-0.3	-1.2	0.2	0.8	-0.3	-0.3	-0.2
Medication: Omeprazole	1.1	1.3	7.2	0.4	0.1	0.4	2.0	-2.7	-0.0	0.6	-0.6	-0.4	-0.4
Medication: Seretide 50 evohaler	0.2	0.3	1.3	-0.0	-0.5	-0.0	1.0	-1.1	0.3	0.3	-0.2	0.0	-0.3
Mean time to correctly identify matches	0.8	1.5	6.0	-1.6	-2.4	0.4	1.3	0.2	0.8	-1.3	0.4	0.7	-1.3
Heart disease (mother)	0.5	0.6	1.7	1.1	0.5	1.2	0.6	0.1	0.0	1.3	0.8	0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.7	1.2	0.5	0.6	0.8	-1.3	-1.1	1.3	-0.7	0.1	0.2
Whole body fat mass	1.1	4.6	9.4	3.1	3.0	-0.3	1.0	-2.0	-2.2	2.7	-1.0	-2.0	2.4
Leg fat mass (right)	1.2	4.6	9.7	3.0	3.1	-0.3	0.9	-1.7	-2.7	2.6	-0.9	-1.8	2.4
Arm predicted mass (right)	0.3	1.6	4.6	0.6	0.6	-0.6	1.6	-1.5	-2.1	0.4	-1.5	-1.1	1.1
Pulse rate, automated reading	0.3	1.0	4.4	-0.2	-1.1	-2.1	0.8	0.7	-0.8	-0.4	0.9	0.3	-1.4
Alcohol intake frequency.	1.0	2.4	10.5	0.7	0.9	-0.1	-0.1	-0.5	-1.8	0.9	-1.7	-3.2	2.3
Comparative height size at age 10	0.1	0.7	3.5	-0.1	-0.1	-1.1	1.9	-1.4	-0.2	0.0	-0.4	0.4	-0.6
Number of full sisters	1.2	1.4	4.2	0.6	0.7	1.2	-1.1	-0.3	-1.9	0.8	-1.1	-2.0	1.0
Suffer from ‘nerves’	0.7	1.1	2.3	-1.1	-0.3	-1.2	-0.1	1.5	1.4	-0.9	1.5	0.5	-0.5
Overall health rating	0.8	1.7	4.3	2.1	1.6	0.3	-0.5	-0.2	-0.8	2.1	0.7	-1.4	1.3
Chest pain or discomfort	1.2	1.8	3.6	1.7	1.9	-1.1	-0.6	-1.5	-1.4	1.9	0.9	-1.2	-0.1
Had major operations	0.6	0.7	2.5	-0.8	0.3	1.0	0.9	-1.6	-0.8	-0.9	-0.3	0.0	-0.9
Age at last live birth	0.6	0.9	2.2	1.3	0.7	1.0	-1.1	-0.4	-0.2	1.5	-0.9	-1.1	0.4
Family relationship satisfaction	1.5	1.8	7.9	-1.2	-1.2	0.2	2.8	1.6	0.6	-1.6	0.7	1.3	-0.2
Leg pain on walking	0.4	0.5	1.7	0.5	0.7	0.9	-0.1	-0.0	-0.5	0.5	0.5	-1.1	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.7	0.3	0.2	-0.2	-1.2	0.1	-1.8	0.1	-0.5	-1.4	2.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	2.7	-0.4	0.2	1.7	0.7	-0.5	-0.5	-0.4	0.0	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.0	-1.4	-1.2	-0.2	-0.0	-1.4	0.4	-1.2	-0.2	0.3	-0.9
Medication: Aspirin	1.5	2.0	6.2	1.7	2.5	0.2	0.6	-0.5	-1.3	1.7	-1.0	-1.9	1.0
Supplements: Vitamin C	2.6	3.0	5.1	-1.5	-0.2	-1.8	2.0	1.0	2.3	-1.7	2.1	1.9	-1.8
Knee pain experienced in last month	0.4	0.6	1.6	-1.3	0.7	-0.5	0.1	0.5	-0.7	-1.2	0.9	-0.7	-0.3
Hypertension (Self-reported)	1.1	2.9	8.0	2.8	2.6	-0.5	-0.6	-1.1	-1.8	2.5	-0.3	0.1	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	-1.0	-0.3	-0.8	-0.7	1.3	-0.3	-1.1	1.1	0.0	0.7
Illnesses of father: Heart disease	0.4	0.5	2.1	-1.0	-0.3	0.0	-0.4	1.5	-0.9	-0.8	0.4	-0.6	0.1
Illnesses of siblings: Diabetes	3.0	3.7	12.5	2.3	2.2	0.3	-0.8	-1.1	-1.6	2.3	-0.9	-1.8	3.5
Smoking status: Previous	0.3	0.5	1.7	-0.5	-0.4	-0.3	-0.5	1.3	-1.0	-0.6	1.0	0.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.8	0.8	0.9	-1.7	0.4	-0.7	-0.8	0.9	-1.1	-0.2	-0.4
Whole body fat-free mass	0.2	1.3	3.2	0.3	0.5	-0.5	1.8	-1.5	-1.8	0.2	-1.4	-1.1	0.9
Leg fat-free mass (right)	0.3	1.5	4.0	1.0	1.0	-0.6	2.0	-1.4	-1.6	0.8	-1.5	-0.8	0.6
Arm fat percentage (left)	1.0	3.8	8.2	2.9	2.4	0.3	0.7	-2.2	-1.8	2.6	-1.3	-2.0	2.0
Average weekly red wine intake	1.6	2.4	10.4	-1.8	-1.1	-0.4	0.8	2.1	1.2	-1.5	-0.1	0.8	-3.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.3	-0.3	-0.2	0.4	1.1	0.6	0.8	-0.5	0.4	1.0	-0.6
Mood swings	0.5	0.8	2.8	0.8	-0.1	1.4	-0.7	-0.7	0.0	0.8	-0.4	-1.0	1.7
Loneliness, isolation	0.3	0.4	2.2	-0.4	0.2	-0.6	1.5	0.7	0.1	-0.6	0.7	0.2	0.3
Long-standing illness, disability or infirmity	0.8	1.3	4.3	0.7	0.4	-0.3	1.1	-1.9	-2.1	0.7	-0.9	-1.0	-0.7
Ever had bowel cancer screening	2.6	3.1	8.9	-2.3	-2.2	1.8	3.0	-1.1	0.7	-2.3	1.0	-0.5	-0.4
Diabetes diagnosed by doctor	0.6	0.9	5.2	0.4	0.7	0.4	2.3	0.1	-0.7	0.3	0.5	-0.6	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.4	-0.7	-1.2	-0.8	-1.5	1.1	-2.1	-0.6	-2.3	-1.2	-0.7
Friendships satisfaction	0.5	0.7	2.5	0.0	-1.0	-0.9	1.6	0.7	0.2	-0.2	-0.5	1.2	-0.4
Qualifications: nursing, teaching	0.4	0.6	3.2	-0.0	-0.3	0.4	0.0	-1.8	1.0	-0.2	-1.0	0.6	0.7
Commuting to job workplace: Walk	0.6	0.6	4.5	-0.4	-0.5	-2.1	0.2	0.8	-0.1	-0.4	-0.5	0.6	-0.1
Eye problems/disorders: Cataract	2.7	3.1	6.7	-2.1	-0.6	-0.3	2.6	1.5	1.8	-2.3	1.2	1.6	-2.2
Mouth/teeth dental problems: Mouth ulcers	3.1	5.0	14.2	3.8	3.4	0.1	-0.2	-1.1	-1.6	3.4	0.6	-0.7	2.7
Medication for cholesterol	0.3	0.5	1.6	-0.9	-0.5	0.1	-0.3	0.4	1.1	-0.7	1.2	-0.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.5	0.3	0.5	-0.8	-0.5	0.1	-1.2	-0.2	0.5	-0.2	0.7
Back pain experienced in last month	0.5	0.7	1.9	-0.7	-0.5	-0.9	-1.1	0.4	-1.4	-0.7	-0.1	-1.2	0.4
Mineral and other dietary supplements	1.4	1.9	4.8	2.2	0.1	-0.1	-1.4	-1.8	-0.1	1.8	-0.6	-0.8	2.2
Breast cancer (self-reported)	2.1	2.5	6.6	-0.3	-0.1	1.1	2.6	0.8	1.6	-0.2	2.2	2.3	-1.8
Asthma (self-reported)	0.6	1.2	3.0	1.0	0.4	0.3	-0.3	-1.5	-1.1	1.0	-1.3	-1.7	1.4
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.2	-0.9	1.0	0.6	0.1	0.1	-0.5	0.6	0.6	0.5
Osteoarthritis (self-reported)	0.2	0.3	0.7	-0.8	-0.1	-0.5	0.8	-0.2	0.2	-0.7	0.3	-0.1	-0.7
Medication: Aspirin	0.8	1.1	3.9	0.8	1.6	0.2	0.5	-0.3	-1.2	0.8	-1.1	-2.0	0.6
Medication: Gliclazide	1.3	1.4	6.4	0.1	0.2	-2.3	-0.3	0.8	-2.5	-0.1	-0.1	-0.7	1.1
Illnesses of father: None of the above (group 1)	0.2	0.3	1.3	-0.2	0.1	-1.1	-0.6	0.2	-0.2	-0.4	0.1	0.3	-0.9
Smoking status: Current	0.2	0.4	0.9	0.5	-0.4	0.2	-0.6	0.2	0.9	0.7	-0.5	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.2	15.5	-2.2	-1.7	-0.5	3.9	1.0	1.2	-2.3	1.4	1.9	-2.3
Whole body water mass	0.2	1.4	3.4	0.3	0.4	-0.6	1.9	-1.6	-1.8	0.2	-1.5	-1.0	0.8
Leg predicted mass (right)	0.3	1.4	3.9	1.0	0.9	-0.7	2.0	-1.4	-1.5	0.8	-1.5	-0.8	0.6
Arm fat mass (left)	0.9	3.8	7.3	2.7	2.4	-0.1	1.5	-2.2	-1.9	2.4	-1.2	-1.8	1.8
Number of self-reported non-cancer illnesses	1.4	2.4	5.2	1.9	1.6	-0.5	0.9	-1.9	-2.3	1.8	-1.1	-1.4	1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.9	1.2	0.8	-1.2	0.6	-0.8	-0.0	1.4	-0.7	0.6	-0.0
Miserableness	1.2	2.1	8.9	1.3	1.2	0.1	-0.7	-0.5	-1.2	1.2	-1.0	-2.0	3.0
Guilty feelings	2.3	3.4	9.5	1.4	1.6	-2.0	-1.0	-0.2	-2.5	1.5	-0.8	-3.1	2.4
Wears glasses or contact lenses	0.5	0.5	1.8	-0.8	-0.5	-0.3	1.4	-0.3	-0.0	-1.1	0.6	0.9	-0.4
Ever taken oral contraceptive pill	0.9	1.0	3.5	-0.6	-1.1	1.1	-1.3	-1.9	0.2	-0.6	-1.0	-1.0	0.1
Hearing aid user	1.4	1.6	6.2	-2.5	-1.4	-0.1	-0.7	0.1	-0.1	-2.5	0.4	0.4	-0.7
Mother’s age at death	0.4	0.5	1.6	-1.0	0.5	-0.7	0.3	1.3	-0.3	-1.0	0.1	-0.6	0.0
Financial situation satisfaction	0.5	0.7	1.7	1.3	0.3	0.6	-1.0	-0.4	-1.0	0.8	-0.2	0.2	1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	0.8	1.2	-0.6	0.3	0.2	-1.2	0.8	-0.8	-1.0	0.7
Commuting to job workplace: Public transport	0.6	0.7	2.4	1.5	0.5	-0.8	-0.6	-0.6	0.2	1.3	-1.0	-0.1	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.6	-0.8	-1.0	-1.3	0.9	-0.9	-0.5	-0.8	-1.1	-0.5	0.3
Medication: Blood pressure	0.8	1.4	3.5	1.6	1.3	-1.3	0.4	-1.0	-1.9	1.3	-1.2	0.7	0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	6.0	0.2	0.8	0.4	-0.6	-1.7	-1.8	0.4	-1.6	-2.4	0.8
Supplements: Fish oil (including cod liver oil)	3.3	4.3	9.1	-2.6	-0.4	0.1	2.2	2.4	1.6	-2.5	2.1	2.0	-3.0
High cholesterol (Self-reported)	0.8	1.5	3.2	1.7	1.8	0.5	-1.0	0.1	-1.3	1.7	-0.4	-1.3	1.1
Medication: Bendroflumethiazide	0.6	0.8	2.7	-0.7	-0.3	-1.1	-0.3	1.6	-1.1	-0.9	0.2	0.8	-1.1
Medication: Paracetamol	0.6	1.0	4.8	-0.4	-0.6	0.7	2.2	-0.2	-0.7	-0.4	0.9	1.2	-1.0
Medication: Lisinopril	1.6	2.1	5.2	0.6	1.6	-0.9	0.2	2.0	0.7	0.6	2.3	2.1	-1.5
Medication: Atorvastatin	1.6	1.9	4.1	1.9	1.6	1.1	1.3	-1.2	-0.8	2.0	-1.3	-1.3	1.0
Illnesses of father: High blood pressure	0.7	0.8	2.1	0.9	1.2	0.2	1.4	-0.2	0.0	0.9	1.1	1.1	-0.7
Alcohol drinker status: Never	1.8	2.2	7.5	0.1	1.3	-2.1	-1.3	0.5	-2.0	0.5	-1.0	-2.7	1.1
Ever smoked	0.3	0.6	3.6	0.2	-0.5	1.1	-1.9	0.5	0.1	0.2	0.7	-0.0	0.1
Basal metabolic rate	0.3	1.6	3.5	0.8	0.8	-0.5	1.8	-1.6	-1.9	0.6	-1.4	-1.2	1.1
Leg fat percentage (left)	1.4	5.2	10.1	3.2	3.0	-0.3	0.4	-1.2	-2.9	2.8	-1.1	-2.1	3.1
Arm fat-free mass (left)	0.3	1.7	6.3	0.6	0.8	-0.6	1.5	-1.3	-2.5	0.4	-1.5	-1.2	1.2
Number of operations (self-reported)	0.9	1.4	3.0	0.5	0.7	-0.9	1.7	-1.6	-1.6	0.2	-1.1	-0.9	1.4
Average weekly beer plus cider intake	0.6	0.9	2.1	1.1	0.7	-0.8	0.6	1.2	0.2	0.8	1.1	1.4	0.7
Irritability	0.1	0.2	1.1	-0.1	-0.2	0.0	-0.2	0.6	0.3	-0.1	1.0	0.1	0.9
Risk taking	1.2	1.7	5.7	-0.1	-0.3	1.0	-0.4	-2.0	-1.7	-0.0	-2.4	-1.3	1.3
Ever had prostate specific antigen (PSA) test	1.0	1.2	6.1	1.1	1.0	0.6	1.3	-2.5	-0.3	0.9	0.0	-0.5	0.3
Fractured/broken bones in last 5 years	1.1	1.4	3.4	-1.2	-1.8	1.9	0.8	0.8	0.5	-0.8	-1.2	0.4	-1.7
Age started oral contraceptive pill	0.2	0.3	1.1	-0.5	0.4	-0.8	-0.1	-1.0	0.5	-0.5	-0.3	-0.2	0.5
Diastolic blood pressure, automated reading	0.2	0.7	2.5	1.1	-0.0	-0.8	-0.1	-0.5	-1.6	0.8	-1.2	-0.2	0.5
Ever depressed for a whole week	1.8	2.2	12.5	-0.4	-0.2	1.4	1.3	1.2	1.2	-0.3	3.5	1.5	-0.5
Unable to work because of sickness or disability	0.6	0.8	4.4	-0.7	-0.3	-0.4	-0.3	0.4	1.0	-0.6	0.8	0.7	-2.1
Commuting to job workplace: Cycle	0.4	0.5	2.2	0.4	0.3	0.7	-1.2	0.3	0.0	0.5	-0.5	-0.5	1.5
Myopia	0.3	0.5	1.7	-0.7	-0.3	-0.8	0.5	0.4	-1.0	-0.7	-1.3	0.0	-0.3
Vascular/heart problems diagnosed by doctor	1.3	3.5	7.2	-2.7	-2.6	0.2	0.7	1.9	2.2	-2.5	1.2	0.7	-1.9
Cholesterol lowering medication	1.2	1.8	3.8	1.9	0.6	1.0	-0.3	-1.3	-1.1	1.6	-1.4	-1.4	1.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	8.3	0.5	0.2	-0.6	1.5	-2.9	0.0	0.8	-0.5	-0.5	-0.1
Pain experienced in last month	0.7	1.2	3.7	1.9	1.1	-0.2	0.6	0.1	1.0	1.9	-1.1	0.8	0.4
Supplements: Calcium	1.1	1.2	3.2	-1.8	-0.9	0.6	0.0	0.8	-1.4	-1.5	-0.6	-0.5	-1.4
Basal cell carcinoma (self-reported)	0.6	0.8	3.6	0.4	0.2	-0.6	-0.7	-0.7	0.0	0.1	-0.9	-1.2	1.9
Heart attack/myocardial infarction (self-reported)	1.0	1.3	5.3	1.4	2.3	0.1	0.1	-0.2	-0.8	1.4	-0.5	-1.6	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.8	0.6	0.3	-1.9	0.4	-0.4	1.2	0.3	-0.4	0.2	-0.2
Heart disease (siblings)	2.1	2.6	6.2	2.4	1.2	1.6	-0.8	-0.5	-1.8	2.5	-1.6	-1.3	1.2
Alcohol drinker status: Previous	0.4	0.5	1.7	-0.6	-1.1	0.7	0.3	-0.4	-0.6	-0.5	-0.6	-1.3	-0.1
Pack years of smoking	0.6	0.9	2.1	1.3	1.2	0.3	-0.4	-0.8	0.4	1.4	1.0	0.3	1.4
Impedance of whole body	0.3	1.7	9.3	0.6	0.2	-0.6	-3.0	1.1	1.5	0.6	1.5	0.8	0.0
Leg fat mass (left)	1.3	4.9	9.4	3.1	3.0	-0.5	1.3	-1.8	-2.7	2.7	-1.1	-1.9	2.6
Arm predicted mass (left)	0.4	1.9	5.7	0.8	0.9	-0.4	1.9	-1.6	-2.4	0.6	-1.5	-1.2	1.2