Hub : Genes

CD53

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1240 0.0300 2.2e-08 0.090 0.080 0.097 0.097 0.107 5.1e-11 5.7e-10 7.3e-12 7.5e-12 6.5e-13
2 GTEx Brain Cortex 0.3470 0.1000 2.0e-04 0.045 NA 0.034 NA 0.123 2.2e-02 NA 4.0e-02 NA 2.9e-04
3 GTEx Liver 0.6500 0.1190 5.4e-04 -0.010 NA -0.011 NA 0.099 8.7e-01 NA 9.9e-01 NA 1.0e-03
4 GTEx Skin Not Sun Exposed Suprapubic 0.1560 0.0560 3.8e-03 -0.005 NA 0.017 NA 0.004 8.5e-01 NA 3.6e-02 NA 1.8e-01
5 METSIM Adipose 0.0377 0.0160 9.5e-03 -0.001 0.008 0.001 0.009 -0.001 6.8e-01 1.7e-02 2.5e-01 1.5e-02 6.5e-01
6 NTR Blood 0.0298 0.0107 9.0e-04 0.002 0.006 0.001 0.006 0.001 8.8e-02 3.0e-03 1.5e-01 2.6e-03 1.7e-01
7 ROSMAP Brain Pre-frontal Cortex 0.2160 0.0366 0.0e+00 0.201 0.174 0.228 0.217 0.236 3.0e-25 8.6e-22 8.0e-29 2.3e-27 6.7e-30
8 YFS Blood 0.0331 0.0119 5.8e-04 0.016 0.008 0.006 NA 0.003 3.7e-06 8.8e-04 3.0e-03 NA 3.4e-02
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0453 0.0269 4.4e-03 0.024 0.008 0.001 NA 0.009 9.0e-04 3.6e-02 2.6e-01 NA 3.0e-02
10 TCGA Brain Lower Grade Glioma 0.0686 0.0316 4.9e-05 0.016 0.042 0.030 NA 0.021 5.0e-03 1.3e-05 2.2e-04 NA 1.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.8 1.2 4.0 -1.6 -1.1 0.2 -0.6 2.0 0.2 -1.4 -0.2 0.9 -0.9
Bipolar Disorder or Schizophrenia 0.7 1.7 4.1 -1.6 -1.2 0.2 0.4 2.0 1.0 -1.5 1.7 1.2 -1.0
Depressed Affect (Nagel 2018) 0.2 0.4 1.7 0.6 0.5 0.6 -0.0 -0.7 0.2 0.5 0.2 -0.8 1.3
Depression (Nagel 2018) 1.3 1.9 6.0 2.3 1.5 0.1 -0.5 -0.6 0.2 2.5 -0.4 -1.7 1.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.5 -0.7 -0.6 -0.1 0.7 0.0 1.2 -0.5 -0.0 -0.7 -0.5
Neuroticism (Nagel 2018) 0.2 0.5 1.5 0.8 1.2 -0.8 0.0 0.3 0.3 0.8 1.0 -0.5 0.7
Schizophrenia (2018) 0.5 1.1 5.4 -0.7 -0.6 -0.1 1.0 1.0 1.1 -0.8 2.3 0.8 -0.6
Schizophrenia vs Biploar Disorder 0.3 0.4 1.5 -0.0 -0.9 0.8 1.2 0.1 -0.1 -0.3 0.8 -0.3 -0.6
Worry (Nagel 2018) 0.4 0.8 3.0 0.6 0.9 -1.4 -0.7 -0.1 0.4 0.8 1.7 -0.6 -0.2
Alzheimer’s Disease (in mother) 0.8 1.0 7.2 0.3 -0.6 2.7 -0.6 -0.2 1.2 0.0 -0.2 0.1 0.0
Alzheimer’s Disease (in father) 0.8 0.9 3.0 -0.2 -0.0 1.4 1.7 0.2 -0.8 -0.0 0.9 0.9 -1.2
Alzheimer’s Disease (including proxy) 1.2 1.8 9.4 -0.9 -1.4 3.1 1.0 0.9 1.0 -0.9 0.7 1.0 -0.9
Crohns Disease (2017) 0.3 0.6 1.8 -0.9 -0.3 -0.2 0.9 1.3 0.0 -0.7 1.3 -0.1 -0.2
Irritable Bowel Disease (IBD) 1.1 2.6 7.2 -2.7 -2.3 0.5 -0.0 1.9 0.2 -2.5 1.5 0.6 -0.7
Ulcerative Colitis (UC) 2.2 4.0 10.5 -3.2 -3.2 1.0 -0.9 2.1 0.2 -3.2 1.2 0.9 -0.8
Major Depression (MDD) 0.4 0.4 1.1 0.8 0.6 0.3 -0.1 0.9 -0.0 0.8 -0.0 -1.0 0.7
Reaction Time 1.3 2.5 9.5 -2.1 -3.1 1.0 1.2 0.2 0.4 -2.0 -0.1 1.1 -1.7
Verbal and Numeric Reasoning (VNR) 0.2 0.5 3.2 0.0 -0.2 -0.1 0.2 -0.8 1.8 0.1 -0.4 -1.1 0.4
Breast Cancer 1.0 2.4 4.0 2.0 1.6 -1.6 0.8 -1.2 -1.6 1.9 -1.4 -1.2 2.0
Ovarian Cancer 0.5 0.7 2.1 -1.0 0.4 -0.2 0.5 0.7 1.4 -0.8 1.4 0.6 0.1
Prostate Cancer 2.3 3.2 6.2 2.3 1.4 -2.5 0.1 -2.0 -1.8 2.2 -1.5 -1.3 1.7
Age at First Birth 1.1 1.7 5.7 -2.4 -1.2 0.7 -0.7 -0.3 -1.1 -2.0 -0.6 -1.4 -0.7
Bipolar Disorder (2011) 1.6 1.5 4.3 -2.1 -1.9 0.2 1.2 1.1 0.4 -1.9 0.1 0.5 -0.8
Body Mass Index (BMI) (2010) 0.4 0.6 2.2 0.6 1.1 -1.5 0.9 -0.5 0.0 0.4 0.1 0.4 0.7
Coronary Artery Disease (CAD) 1.5 1.7 5.4 -1.5 -2.0 0.9 -0.4 2.3 0.8 -1.0 0.5 0.5 -1.6
Crohns Disease (2012) 0.4 0.6 2.9 0.6 1.0 -0.3 0.5 1.7 -0.3 0.9 0.3 -0.7 0.2
Mean Putamen Volume 0.3 0.3 1.1 0.1 -0.5 0.3 1.0 0.8 0.6 -0.1 -0.4 0.6 -0.2
Fasting Glucose 2.1 2.5 7.0 -1.8 -0.8 0.0 0.8 1.9 1.0 -1.7 1.4 2.0 -2.6
HbA1C 0.7 0.8 2.4 -0.6 -1.4 -1.5 -1.0 0.8 0.5 -0.7 -0.9 0.4 -0.2
HDL Cholesterol 0.6 1.1 3.5 -0.3 0.2 0.4 -0.2 -0.7 -1.7 -0.2 -1.9 -1.8 0.1
LDL Cholesterol 0.4 0.6 1.7 0.2 1.3 0.4 0.6 0.5 0.4 0.7 0.4 0.9 -1.2
Lupus 0.5 0.8 2.1 -0.6 -0.2 -1.2 -0.5 -1.4 -0.8 -0.6 -1.1 -1.2 -0.7
Neuroticism (2016) 0.3 0.4 1.3 0.0 -0.1 0.2 -0.4 0.7 1.0 0.0 1.1 -0.0 1.1
Primary Biliary Cirrhosis 0.9 1.3 4.3 -1.7 -0.5 -0.6 -1.2 -0.4 0.6 -1.5 0.3 -2.1 0.9
Rheumatoid Arthritis 1.4 1.9 7.4 -0.0 0.3 -1.3 -2.0 2.7 1.8 0.1 0.3 -0.9 1.5
Schizophrenia (2014) 1.1 2.4 4.2 -1.8 -1.5 0.1 1.3 1.7 1.4 -1.8 2.0 1.4 -1.6
Triglycerides 0.8 1.4 3.9 0.9 2.0 -0.6 0.9 0.1 1.1 1.3 1.6 1.2 -0.8
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.7 1.0 0.7 -0.7 -0.3 -1.2 -0.2 1.3 -0.1 -0.2 0.8
Ulcerative Colitis 1.1 1.6 4.9 -1.6 -1.9 0.4 -1.3 2.2 0.5 -1.5 0.7 0.2 0.2
Blood Eosinophil Count 1.8 13.6 25.6 2.9 3.2 -1.2 -4.2 -2.3 -4.8 2.8 -4.3 -5.1 4.3
Blood Platelet Count 0.5 5.6 42.8 0.1 -0.2 -0.6 -6.5 -1.0 0.1 0.0 0.4 -1.9 2.8
Blood Red Count 0.1 1.2 4.2 1.2 1.4 -0.6 0.6 -2.1 -0.0 1.1 -0.0 -0.8 1.3
Blood White Count 0.2 1.8 6.8 -0.1 0.3 -0.5 -2.6 0.0 -1.5 -0.2 -0.9 -2.0 2.0
Heel T-Score 0.0 0.2 0.6 -0.1 0.2 0.7 -0.4 0.2 0.1 -0.1 -0.8 -0.5 0.4
BMI 0.8 4.8 8.9 2.6 2.4 -0.9 2.2 -2.0 -3.0 2.4 -2.0 -1.9 1.9
Height 0.1 1.8 11.8 -1.1 -0.1 -3.4 -1.6 -0.1 0.4 -1.0 0.2 -0.7 0.7
Waist Hip Ratio (WHR) 0.1 0.7 1.8 0.7 0.8 -0.5 -1.1 -0.3 0.5 0.4 1.0 -1.4 0.9
Systolic Blood Pressure 0.4 2.0 5.7 1.1 0.5 -2.4 -0.5 -0.2 -2.0 1.1 -2.0 -1.1 1.3
Smoking Status 0.2 0.5 1.8 -0.5 -0.5 0.4 -1.3 1.1 0.4 -0.5 0.7 -0.6 0.1
Allergy or Eczema 0.2 0.5 1.2 -0.4 -1.1 0.7 0.2 0.6 -0.2 -0.5 -1.0 0.9 -0.7
Cardiovascular Disease 1.2 4.0 8.5 2.9 2.8 0.6 -2.6 0.3 -2.4 2.7 -0.1 -0.5 1.7
Hypothyroidism (self reported) 1.3 3.0 9.2 0.5 1.4 -1.4 0.4 0.6 -3.0 0.5 -2.2 -2.3 2.4
Respiratory disease 0.6 1.4 4.3 1.2 0.4 0.5 -0.6 -1.6 -0.5 1.2 -1.3 -2.1 1.2
Type 2 Diabetes (T2D) (2018) 1.1 2.0 8.0 1.4 1.2 -0.4 1.2 -1.0 -1.7 1.3 -0.2 -1.1 2.8
Lung FEV1/FVC ratio 1.3 6.5 52.9 -0.2 0.8 -1.2 7.3 2.4 0.6 -0.0 0.2 1.1 -1.6
Lung FVC 0.2 1.2 2.4 -1.3 -1.4 0.1 1.4 0.5 -0.5 -1.3 -1.3 0.2 -1.6
Neuroticism 0.3 0.7 1.9 0.7 1.2 -0.6 -0.4 -0.1 0.1 0.7 1.1 -1.1 1.4
Chronotype (morning person) 0.2 0.5 1.7 -0.9 -0.6 0.7 -1.3 0.5 0.2 -0.7 -0.1 0.4 -0.9
Hair Pigment 0.1 2.0 5.1 -2.2 -2.1 0.8 -0.3 0.0 2.0 -1.9 1.0 0.7 0.1
Tanning 0.1 1.0 5.4 0.7 0.8 -2.3 0.3 1.0 -0.2 0.5 1.0 -0.3 0.9
Hand grip strength (left) 0.2 0.5 1.5 -1.1 -0.0 0.6 0.2 0.3 -0.6 -1.2 -0.7 0.5 -0.6
Number of treatments/medications taken 1.2 2.1 7.5 0.6 1.8 -1.0 1.1 -1.3 -2.7 0.7 -1.1 -2.1 0.5
Average weekly spirits intake 0.6 0.8 2.0 0.7 1.1 -0.9 0.5 -1.4 -0.7 1.4 -0.3 -0.1 -0.5
Sensitivity / hurt feelings 0.3 0.5 1.7 -0.0 0.8 -1.1 -0.1 1.0 -1.3 -0.1 0.4 0.2 -0.8
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 1.1 0.5 -0.1 0.9 -0.2 0.9 1.1 0.4 -0.4 0.4
Hearing difficulty/problems: Yes 0.4 0.6 1.5 -1.2 -0.5 -0.3 -0.9 0.7 -0.6 -1.2 0.7 -0.2 -0.9
Relative age of first facial hair 0.1 0.3 1.1 -0.5 -0.5 0.6 0.4 -0.0 1.1 -0.3 0.9 0.3 -0.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.9 -0.3 -0.2 0.6 -0.1 -0.9 -0.8 -0.2 -0.8 -1.4 -0.2
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.5 -0.9 -0.1 -0.3 0.6 0.6 1.0 -1.2 1.2 1.0 0.6
Ever had hysterectomy (womb removed) 1.3 1.5 3.9 0.4 1.6 -0.9 -0.3 -1.9 -0.9 0.4 -0.2 -1.7 2.0
Systolic blood pressure, automated reading 0.2 0.5 1.9 0.8 0.2 -0.6 0.2 -0.6 -1.2 0.5 -1.4 -0.1 0.7
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.5 -1.1 0.0 -0.1 0.5 1.7 -2.1 -1.1 -1.3 -1.0 0.5
Angina 1.4 1.8 4.2 1.5 2.0 -0.2 -0.5 -0.3 -0.8 1.5 -1.1 -2.0 1.9
Medication for hormone replacement therapy 0.6 0.7 2.3 -0.8 0.1 -0.2 0.3 0.5 1.1 -1.0 1.3 1.5 -0.3
Vitamin and mineral supplements 1.3 1.8 4.0 1.9 0.3 1.0 -1.7 -1.0 -1.0 1.8 -0.3 -0.8 2.0
Supplements: Zinc 0.4 0.4 1.8 -0.2 -0.3 -1.0 0.6 -0.3 -0.6 -0.2 -1.3 -0.4 -0.2
Medication: Co-codamol 1.2 1.4 4.6 -0.1 0.5 -1.3 -1.4 2.1 -0.1 0.0 2.1 0.4 -0.6
Medication: Metformin 0.5 0.7 2.5 -0.3 0.5 -0.2 0.5 -0.6 -1.3 -0.3 -0.0 -1.6 1.5
Diabetes (father) 1.0 1.2 4.9 -0.1 0.5 -2.2 0.6 1.6 1.1 -0.2 1.5 0.5 0.4
Diabetes (mother) 2.5 3.2 6.7 2.2 2.3 0.1 0.6 -2.6 -1.6 2.4 -0.8 -2.0 1.3
Severe depression (siblings) 1.0 1.1 3.2 0.5 1.8 -1.5 1.2 0.6 0.7 0.8 1.4 -0.3 0.7
Pack years adult smoking proportion 0.8 1.2 2.9 1.6 1.1 0.3 -0.7 -0.7 0.7 1.7 1.0 0.5 1.5
Impedance of leg (right) 0.3 1.6 9.9 0.3 0.4 -0.3 -3.1 1.3 0.8 0.3 1.7 0.5 0.5
Leg fat-free mass (left) 0.2 1.2 2.7 0.9 0.9 -0.4 1.6 -1.3 -1.6 0.6 -1.4 -0.9 0.6
Trunk fat percentage 0.9 3.8 9.4 2.9 3.1 -0.3 0.3 -1.3 -2.1 2.7 -0.4 -1.7 1.8
Hand grip strength (right) 0.4 1.0 5.8 0.3 0.3 -0.3 -0.8 -1.0 -1.2 0.2 -2.4 -0.8 0.6
Townsend deprivation index at recruitment 0.6 0.9 2.9 -0.4 -1.3 1.7 0.2 -0.2 1.2 -0.4 0.2 -0.5 1.4
Current tobacco smoking 0.4 0.7 2.0 1.2 0.1 0.7 -0.5 -0.1 0.8 1.4 -0.3 -0.7 1.2
Average weekly fortified wine intake 0.7 0.8 2.6 -1.5 -1.0 -0.9 0.6 0.3 -0.3 -1.6 -0.1 1.1 -0.1
Maternal smoking around birth 0.5 0.8 3.4 1.0 0.5 0.4 -1.8 0.7 -0.6 1.0 -0.3 -0.5 0.9
Fed-up feelings 0.3 0.5 1.9 0.1 -0.5 1.4 -0.9 0.6 -0.3 0.0 -0.3 -0.7 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 4.4 2.0 0.9 0.8 -0.7 0.7 0.1 2.1 0.1 -1.5 0.9
Relative age voice broke 0.4 0.6 2.1 0.7 0.8 0.7 -0.8 -0.8 0.3 0.8 0.5 -1.4 0.8
Taking other prescription medications 0.8 1.2 5.8 -0.3 0.6 -0.4 1.1 -0.8 -2.4 -0.2 -0.0 -1.8 -0.1
Age when periods started (menarche) 0.4 1.0 3.8 -1.0 0.5 -0.6 0.1 1.9 0.1 -1.1 0.7 1.6 -0.3
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 7.1 0.4 1.6 -0.5 -0.3 -0.8 -0.6 0.2 -0.1 -2.0 2.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 6.1 0.5 0.4 -0.4 0.1 -0.6 -1.5 0.4 -2.5 -0.6 0.9
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.7 0.3 1.4 0.6 0.3 0.1 0.3 0.2 1.6 0.8 -0.2
Qualifications: CSEs or equivalent 0.4 0.6 1.8 -0.9 -0.3 -0.6 -1.1 0.2 0.4 -0.9 1.3 -0.8 0.3
Serious illness, injury or assault to yourself 0.3 0.4 1.1 -1.0 -0.2 0.2 -0.6 1.0 0.0 -1.0 -0.1 0.5 -0.2
High blood pressure 1.0 2.7 6.8 2.6 2.4 -0.2 -0.6 -1.3 -1.9 2.3 -0.7 -0.0 1.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.5 0.2 -0.7 0.4 0.3 0.8 0.2 -0.0 -0.8 1.6 -0.9
Multivitamins +/- minerals 1.2 1.5 3.4 -1.8 0.1 -1.0 1.4 1.3 -0.4 -1.5 -1.0 0.7 -1.8
Stomach or abdominal pain in last month 0.7 0.8 3.7 -0.2 0.8 -1.9 -1.2 -0.6 -0.9 -0.2 0.8 -0.6 0.4
Supplements: Glucosamine 0.2 0.3 1.0 -0.7 0.1 -0.3 0.9 0.6 -0.2 -0.5 -0.2 0.1 -1.0
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 5.7 -0.2 -1.4 0.3 1.2 1.7 2.0 -0.2 0.7 2.4 -0.6
Medication: Atenolol 0.6 0.8 2.4 1.1 1.5 -0.9 0.8 0.5 0.2 1.1 -0.1 0.3 1.0
Medication: Levothyroxine sodium 0.6 1.1 4.1 0.3 0.4 -0.3 0.2 -0.1 -2.0 0.4 -1.6 -1.5 1.1
Sitting height 0.0 0.3 0.7 0.9 0.7 0.1 0.0 -0.8 -0.5 0.8 0.2 -0.1 0.2
Chronic bronchitis/emphysema (father) 0.5 0.6 2.1 -0.1 -0.7 0.0 -0.5 -0.3 0.8 0.3 -1.4 -1.5 0.4
High blood pressure (mother) 0.8 1.2 4.3 0.9 1.4 -2.1 0.0 -0.5 -1.5 0.8 -0.3 -0.6 1.0
Body mass index (BMI) 0.8 3.5 5.6 2.4 2.3 0.3 1.7 -1.7 -2.2 2.1 -1.2 -1.8 1.9
Impedance of leg (left) 0.3 1.3 6.1 0.8 0.6 -0.7 -2.5 0.9 0.8 0.8 1.4 0.3 0.9
Leg predicted mass (left) 0.2 1.2 2.6 0.9 0.9 -0.4 1.6 -1.3 -1.6 0.6 -1.3 -0.8 0.6
Trunk fat mass 0.9 4.1 8.6 2.8 2.9 -0.6 0.9 -1.6 -2.3 2.5 -0.8 -2.0 2.1
Waist circumference 0.9 3.3 7.5 1.9 1.6 -0.6 0.7 -1.6 -2.7 1.6 -1.2 -2.6 2.4
Number of incorrect matches in round 1.0 1.6 4.2 -1.8 -1.8 0.4 1.0 0.3 -0.1 -1.6 -0.7 0.5 -2.0
Past tobacco smoking 0.2 0.4 1.7 0.3 0.4 -0.1 1.3 -0.9 0.5 0.4 -0.5 -0.0 0.2
Alcohol usually taken with meals 0.8 1.4 4.2 -1.3 -0.8 -0.1 -2.1 -0.4 -0.6 -1.5 -1.7 -1.1 -0.4
Nervous feelings 0.7 1.4 5.7 -0.6 -0.3 -1.9 0.4 1.5 0.7 -0.6 2.4 0.2 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.8 0.6 0.7 -1.2 -0.3 0.9 1.4 0.5 1.9 0.7 0.5
Hearing difficulty/problems with background noise 0.3 0.4 2.4 0.4 0.2 -0.2 0.4 -1.6 -0.9 0.5 -0.5 0.0 -0.3
Hair/balding pattern: Pattern 2 0.8 1.0 4.3 0.7 0.6 -0.2 0.5 0.0 2.1 0.5 1.6 0.8 0.9
Had menopause 0.4 0.5 1.4 -0.1 -0.1 0.2 0.7 -0.3 1.2 -0.3 1.1 1.1 0.3
Had other major operations 0.3 0.3 2.4 0.5 -0.1 -0.2 1.6 0.0 0.1 0.1 -0.6 -0.2 0.4
Forced vital capacity (FVC) 0.1 0.5 1.5 -0.9 -0.8 -0.3 0.4 0.5 0.3 -0.8 -0.8 0.1 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 3.7 0.2 0.0 0.2 0.3 -0.3 -1.8 0.1 -1.9 -0.3 0.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.9 -1.0 -0.8 0.4 1.3 0.5 -0.0 -1.0 2.0 0.3 -0.3
Qualifications: None of the above 0.8 1.8 5.5 2.2 1.7 0.9 -1.5 0.0 0.3 2.3 0.4 -0.5 1.2
Financial difficulties in last 2 years 1.6 2.2 5.5 2.4 0.5 0.6 -0.9 -0.8 -1.2 2.0 -1.6 -1.8 1.6
Mouth/teeth dental problems 0.3 0.4 1.8 -0.4 -0.9 -0.7 -0.1 0.2 0.3 -0.4 -1.3 0.4 -0.4
Heart attack 0.9 1.2 4.8 1.2 2.2 0.1 -0.0 -0.5 -0.8 1.2 -0.6 -1.6 0.6
Allergy 0.1 0.3 1.3 -1.0 0.1 -0.3 0.4 0.3 0.1 -0.7 1.1 -0.4 -0.1
Pain all over the body in last month 1.6 1.7 5.6 -0.2 -0.3 0.9 0.7 1.4 2.2 -0.1 2.4 1.4 -1.2
Diabetes (self-reported) 0.7 1.0 3.3 1.0 1.5 0.0 1.8 0.2 -0.6 0.9 0.9 -0.1 1.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 2.1 0.3 -0.3 -0.3 0.1 0.6 -1.5 0.2 -1.4 -0.6 0.4
Medication: Ramipril 2.0 2.6 7.4 -0.3 1.6 0.3 -2.2 0.4 -2.7 -0.2 -1.5 -2.2 1.9
Medication: Simvastatin 1.0 1.5 3.7 1.9 1.6 0.6 -0.7 0.3 -0.3 1.6 -0.2 -1.2 1.9
Fluid intelligence score 0.7 1.4 5.3 0.2 -0.7 -1.0 1.4 -2.3 1.7 0.2 -0.6 -1.2 0.5
Illnesses of siblings 1.0 1.5 3.7 -1.8 -0.6 -0.9 1.2 0.1 0.8 -1.8 -0.0 1.0 -1.9
Neuroticism score 0.4 0.7 2.5 0.4 0.6 -0.8 -0.7 0.5 -0.0 0.3 1.3 -1.2 1.6
Weight 0.6 3.1 5.7 1.9 2.0 -0.8 1.6 -1.7 -2.4 1.6 -1.3 -1.9 1.9
Impedance of arm (right) 0.3 1.6 5.0 0.2 -0.1 -0.6 -2.2 1.1 1.9 0.2 1.9 1.1 -0.8
Arm fat percentage (right) 0.9 3.7 7.9 2.8 2.4 0.2 0.8 -1.9 -1.9 2.6 -1.0 -2.0 2.0
Trunk fat-free mass 0.2 1.3 3.2 -0.2 0.0 -0.5 1.8 -1.7 -1.6 -0.3 -1.4 -1.2 0.9
Hip circumference 0.4 1.7 3.0 1.5 1.1 -0.0 1.0 -1.6 -1.7 1.4 -1.3 -1.2 1.5
Time employed in main current job 0.5 0.6 2.7 -0.4 0.6 0.5 0.7 -1.6 0.9 -0.5 0.8 -0.6 0.1
Alcohol intake versus 10 years previously 0.3 0.5 1.3 0.7 0.7 0.9 1.1 -0.4 -0.4 0.4 0.7 1.0 -0.0
Father’s age at death 1.3 1.7 5.5 -2.2 -2.3 0.3 -0.6 0.6 0.3 -2.3 0.5 -0.6 -0.0
Worrier / anxious feelings 0.9 1.7 9.5 -0.1 0.1 0.3 0.3 0.1 1.9 -0.4 3.1 1.6 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.6 0.7 0.6 0.6 -0.5 0.7 0.4 0.5 1.6 -0.3 0.1
Falls in the last year 0.5 0.6 1.4 -1.0 -0.4 -0.9 1.1 -1.2 -0.2 -0.9 -0.1 -0.4 -0.9
Hair/balding pattern: Pattern 3 0.8 1.2 6.0 -0.2 -1.1 1.4 -0.3 -0.2 -1.4 -0.1 -2.4 -0.8 0.1
Number of live births 1.1 1.5 4.9 2.2 -0.2 1.3 1.6 -0.9 0.7 2.2 -0.2 0.2 -0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 5.0 -1.2 -0.8 -0.4 2.2 1.5 0.3 -1.1 -0.1 0.7 -1.7
Pulse rate 0.5 0.9 2.1 -1.3 -1.3 -0.6 0.5 0.5 -0.3 -1.3 1.5 0.2 -0.5
Happiness 0.1 0.1 0.2 0.1 -0.3 -0.1 -0.2 0.2 -0.4 0.1 -0.4 -0.3 0.2
Noisy workplace 1.1 1.4 5.1 0.7 2.3 -0.6 0.2 1.1 -2.1 0.8 1.1 0.4 -0.4
Qualifications: A levels/AS levels or equivalent 0.7 1.5 4.2 -0.2 -0.7 -0.0 2.1 -1.9 0.1 -0.3 -1.2 1.3 -1.8
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 6.2 -0.2 0.5 -1.2 2.5 1.4 -1.0 -0.3 -0.9 0.8 -0.5
Mouth/teeth dental problems: Dentures 0.5 0.8 2.3 -1.5 -1.1 0.2 -0.2 0.8 0.3 -1.4 1.4 0.1 0.3
Asthma 0.6 1.1 2.4 1.2 0.4 0.4 -0.1 -1.4 -1.0 1.1 -1.0 -1.5 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.3 3.6 -1.5 -0.4 -0.2 1.2 0.9 0.5 -1.5 1.4 0.8 -1.9
Medication: Cholesterol lowering 0.5 0.8 4.7 1.0 2.2 -0.5 -0.1 0.3 -0.4 1.0 0.7 -0.3 0.5
Depression (self-reported) 0.3 0.3 1.6 -0.4 -0.5 0.2 1.3 0.0 -0.5 -0.3 -0.4 0.1 -0.8
Medication: Lansoprazole 1.2 1.4 5.7 0.9 0.6 0.2 -0.4 2.4 -0.9 0.7 1.5 -0.0 1.7
Prospective memory result 0.6 0.7 2.5 0.6 0.7 -0.3 -0.5 1.3 0.9 0.5 1.6 0.9 0.2
Lung cancer (father) 0.6 0.7 4.0 0.0 -0.1 0.5 -0.7 2.0 -1.0 -0.1 -0.3 0.4 -0.9
Illnesses of mother 0.6 0.7 2.7 -1.2 -0.8 -0.9 0.5 0.5 0.1 -1.2 -0.2 0.2 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 7.3 -1.1 -0.4 -1.1 2.7 1.5 -0.3 -0.9 -0.5 0.2 -1.5
Pulse wave Arterial Stiffness index 0.4 0.5 2.2 -0.0 0.5 -1.0 -0.8 1.5 -0.2 0.0 0.8 0.3 -0.0
Impedance of arm (left) 0.4 1.7 5.5 0.2 -0.2 -0.5 -2.3 0.9 2.3 0.3 1.7 1.0 -0.9
Arm fat mass (right) 0.7 3.1 5.6 2.4 2.2 -0.1 1.5 -1.8 -1.7 2.1 -0.8 -1.7 1.9
Trunk predicted mass 0.2 1.4 3.3 -0.1 0.1 -0.6 1.8 -1.8 -1.5 -0.2 -1.4 -1.2 1.0
Standing height 0.1 0.6 4.9 -0.2 0.1 -2.2 -0.0 -0.7 -0.4 -0.3 -0.2 -0.5 0.4
Length of working week for main job 0.6 0.6 4.5 0.3 -0.4 0.9 0.4 0.4 0.5 0.0 0.2 2.1 0.5
Exposure to tobacco smoke at home 0.5 0.5 1.4 0.2 0.9 -0.5 -0.1 1.1 -1.2 -0.0 -1.1 -0.6 0.4
Breastfed as a baby 0.5 0.6 1.5 -0.7 -0.6 1.2 -1.1 0.3 0.7 -0.7 -0.1 1.0 0.8
Tense / ‘highly strung’ 0.3 0.4 1.7 -0.4 -0.3 -0.6 -1.3 0.0 0.4 -0.2 1.3 -0.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 7.5 -1.6 -2.7 0.5 0.8 1.4 1.1 -1.7 0.7 0.6 -0.2
Hair/balding pattern: Pattern 4 0.2 0.4 2.0 0.3 0.1 -0.7 1.0 0.4 0.4 0.3 0.7 1.4 -0.2
Birth weight of first child 0.4 0.7 3.2 -0.2 -0.3 -0.2 1.1 0.3 1.8 -0.3 1.0 0.9 0.3
Peak expiratory flow (PEF) 0.6 1.4 6.4 0.4 0.8 -0.8 1.8 2.5 -0.3 0.7 0.4 0.7 -1.3
Pulse wave reflection index 0.4 0.6 4.0 -0.3 -0.8 0.1 -0.5 2.0 0.0 -0.3 0.1 0.2 -0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.6 0.2 0.4 1.0 0.4 -0.6 -0.3 -0.0 1.6 0.5 -0.5
Loud music exposure frequency 1.2 1.3 3.0 1.1 0.5 1.5 0.2 -1.7 1.6 1.2 -0.1 0.5 1.4
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 3.7 -1.6 -1.3 -1.0 1.0 -0.9 -0.6 -1.9 -0.1 1.3 -1.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.6 0.7 0.8 0.4 -0.4 -0.8 -0.2 0.5 0.5 -1.3 0.2
Blood clot in the leg (DVT) 0.4 0.6 2.9 0.8 0.6 -1.7 -0.1 -0.6 1.1 0.4 -0.4 -0.1 0.0
Medication: Paracetamol 0.6 1.0 5.6 -0.0 -0.4 0.9 2.4 -0.2 -0.5 0.2 1.0 0.9 -1.3
Headache pain in last month 0.5 0.9 4.6 -0.3 -0.4 0.7 -0.6 -1.2 -2.1 -0.3 -0.6 -1.0 0.8
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.8 -0.1 -1.6 -0.1 0.6 1.0 1.7 -0.3 0.2 1.6 -0.9
Glaucoma (self-reported) 0.9 1.1 3.3 -0.5 -1.4 -0.8 1.0 -1.1 -1.2 -0.5 -1.8 -0.8 0.2
Gout (self-reported) 0.5 0.7 2.6 0.4 1.6 -1.4 1.0 -1.1 -0.4 0.5 0.2 -0.6 -0.0
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.1 0.3 0.5 -0.4 0.9 0.8 -2.0 0.3 -1.5 -1.7 1.5
Medication: Amlodipine 1.1 1.5 5.0 1.6 1.5 -0.1 2.2 -1.4 0.9 1.5 0.2 0.4 -0.3
Medication: Ventolin 100micrograms inhaler 1.6 2.0 3.9 1.9 0.5 0.3 -1.3 -2.0 -1.6 1.8 -1.1 -1.3 1.2
Birth weight 1.4 3.0 9.9 -3.0 -2.6 0.7 0.6 0.3 0.5 -3.1 0.2 0.7 -1.6
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.0 0.0 0.2 0.5 0.8 0.8 0.3 -0.2 1.0 -0.3 0.3
High blood pressure (siblings) 1.8 2.5 7.9 2.8 1.5 -0.0 -1.0 -0.4 -1.2 2.8 0.1 -1.2 1.9
Forced vital capacity (FVC), Best measure 0.3 0.9 2.2 -1.1 -0.7 -1.0 1.2 0.8 -0.5 -1.0 -0.9 0.0 -1.5
Body fat percentage 1.1 4.5 9.6 3.1 3.0 -0.1 0.4 -1.7 -2.4 2.8 -0.8 -2.1 2.3
Leg fat percentage (right) 1.3 4.7 8.8 3.0 3.0 -0.1 0.0 -1.2 -2.9 2.6 -0.9 -2.1 2.7
Arm fat-free mass (right) 0.3 1.8 4.5 0.9 1.0 -0.9 1.5 -1.6 -2.1 0.7 -1.6 -1.1 1.3
Exposure to tobacco smoke outside home 0.5 0.7 1.3 1.1 0.5 -0.7 0.4 -1.1 -0.5 0.9 -1.0 -0.3 1.0
Comparative body size at age 10 0.3 0.7 2.4 0.3 0.1 0.2 0.1 -1.5 -0.6 0.0 -1.3 -0.7 1.5
Number of full brothers 1.5 1.9 7.7 2.6 1.6 0.1 -0.4 -0.1 -0.7 2.8 0.6 -0.8 0.7
Worry too long after embarrassment 0.3 0.5 1.8 -0.3 0.7 -1.2 -0.3 1.3 0.5 -0.1 0.9 0.2 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 -0.3 -1.0 1.0 0.6 1.2 -0.1 -0.4 0.2 -0.2 -0.2
Wheeze or whistling in the chest in last year 1.4 2.5 7.1 1.1 1.5 -1.0 -1.3 -0.1 -2.7 1.0 -0.6 -2.5 2.1
Number of children fathered 1.1 1.3 5.5 0.3 1.7 -2.3 -0.5 0.2 -1.2 0.7 0.3 -1.5 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 5.1 -1.2 0.3 -0.5 -1.0 1.1 1.3 -1.1 1.5 2.2 -1.4
Age at first live birth 0.1 0.3 1.0 0.4 0.7 -0.5 -0.5 0.2 -0.3 0.5 0.0 -1.0 0.2
Pulse wave peak to peak time 0.4 0.5 2.6 -0.2 -0.5 0.8 0.7 -1.6 0.4 -0.2 -0.7 -0.4 0.0
Health satisfaction 1.4 1.8 4.2 -1.6 -0.8 0.5 0.8 1.4 0.0 -1.6 2.0 1.4 -1.9
Shortness of breath walking on level ground 0.7 0.8 2.1 0.6 1.1 -0.3 -0.8 -0.6 -1.3 0.7 0.1 -1.2 1.4
Qualifications: College or University degree 0.8 2.6 6.4 -0.1 -0.3 1.4 2.4 -1.8 1.8 0.1 -1.2 2.1 -2.5
Eye problems/disorders: None of the above 1.5 1.8 10.9 0.9 0.0 1.0 -3.3 0.1 -0.8 1.1 -0.1 -1.3 1.2
Mouth/teeth dental problems: Loose teeth 0.5 0.6 4.5 -0.0 0.0 2.1 -0.2 -0.1 0.1 -0.1 0.3 1.1 0.2
Emphysema/chronic bronchitis 0.6 0.7 1.7 1.2 0.9 0.2 -1.0 0.1 0.8 1.3 0.8 0.3 0.8
Medication for pain relief, constipation, heartburn 0.7 1.2 5.7 -0.4 -1.1 0.1 -2.4 1.2 1.4 -0.5 -0.2 0.0 1.3
Neck or shoulder pain in last month 0.9 1.2 3.5 -1.4 -1.2 -0.4 -0.6 0.7 -1.9 -1.5 0.1 0.0 -1.5
Medication: Blood pressure 0.5 0.9 2.7 0.1 1.7 0.4 -0.8 -0.8 -1.1 0.2 -0.3 -1.5 1.2
Angina (self-reported) 1.4 1.9 4.2 1.7 2.0 -0.2 -0.3 -0.2 -0.8 1.8 -1.0 -1.7 1.9
Migraine (self-reported) 0.8 0.9 2.6 0.5 1.3 -0.1 0.8 -1.3 -1.2 0.4 0.8 -0.6 1.6
Medication: Ibuprofen 0.9 1.1 4.0 -2.0 -0.9 0.2 0.2 0.6 -0.3 -2.0 0.6 -0.1 -1.2
Medication: Allopurinol 0.3 0.4 1.6 0.7 1.3 -0.1 -0.3 -1.2 0.2 0.8 -0.3 -0.3 -0.2
Medication: Omeprazole 1.1 1.3 7.2 0.4 0.1 0.4 2.0 -2.7 -0.0 0.6 -0.6 -0.4 -0.4
Medication: Seretide 50 evohaler 0.2 0.3 1.3 -0.0 -0.5 -0.0 1.0 -1.1 0.3 0.3 -0.2 0.0 -0.3
Mean time to correctly identify matches 0.8 1.5 6.0 -1.6 -2.4 0.4 1.3 0.2 0.8 -1.3 0.4 0.7 -1.3
Heart disease (mother) 0.5 0.6 1.7 1.1 0.5 1.2 0.6 0.1 0.0 1.3 0.8 0.3 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 1.7 1.2 0.5 0.6 0.8 -1.3 -1.1 1.3 -0.7 0.1 0.2
Whole body fat mass 1.1 4.6 9.4 3.1 3.0 -0.3 1.0 -2.0 -2.2 2.7 -1.0 -2.0 2.4
Leg fat mass (right) 1.2 4.6 9.7 3.0 3.1 -0.3 0.9 -1.7 -2.7 2.6 -0.9 -1.8 2.4
Arm predicted mass (right) 0.3 1.6 4.6 0.6 0.6 -0.6 1.6 -1.5 -2.1 0.4 -1.5 -1.1 1.1
Pulse rate, automated reading 0.3 1.0 4.4 -0.2 -1.1 -2.1 0.8 0.7 -0.8 -0.4 0.9 0.3 -1.4
Alcohol intake frequency. 1.0 2.4 10.5 0.7 0.9 -0.1 -0.1 -0.5 -1.8 0.9 -1.7 -3.2 2.3
Comparative height size at age 10 0.1 0.7 3.5 -0.1 -0.1 -1.1 1.9 -1.4 -0.2 0.0 -0.4 0.4 -0.6
Number of full sisters 1.2 1.4 4.2 0.6 0.7 1.2 -1.1 -0.3 -1.9 0.8 -1.1 -2.0 1.0
Suffer from ‘nerves’ 0.7 1.1 2.3 -1.1 -0.3 -1.2 -0.1 1.5 1.4 -0.9 1.5 0.5 -0.5
Overall health rating 0.8 1.7 4.3 2.1 1.6 0.3 -0.5 -0.2 -0.8 2.1 0.7 -1.4 1.3
Chest pain or discomfort 1.2 1.8 3.6 1.7 1.9 -1.1 -0.6 -1.5 -1.4 1.9 0.9 -1.2 -0.1
Had major operations 0.6 0.7 2.5 -0.8 0.3 1.0 0.9 -1.6 -0.8 -0.9 -0.3 0.0 -0.9
Age at last live birth 0.6 0.9 2.2 1.3 0.7 1.0 -1.1 -0.4 -0.2 1.5 -0.9 -1.1 0.4
Family relationship satisfaction 1.5 1.8 7.9 -1.2 -1.2 0.2 2.8 1.6 0.6 -1.6 0.7 1.3 -0.2
Leg pain on walking 0.4 0.5 1.7 0.5 0.7 0.9 -0.1 -0.0 -0.5 0.5 0.5 -1.1 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.7 0.3 0.2 -0.2 -1.2 0.1 -1.8 0.1 -0.5 -1.4 2.2
Commuting to job workplace: Car/motor vehicle 0.4 0.4 2.7 -0.4 0.2 1.7 0.7 -0.5 -0.5 -0.4 0.0 -0.1 -0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.0 -1.4 -1.2 -0.2 -0.0 -1.4 0.4 -1.2 -0.2 0.3 -0.9
Medication: Aspirin 1.5 2.0 6.2 1.7 2.5 0.2 0.6 -0.5 -1.3 1.7 -1.0 -1.9 1.0
Supplements: Vitamin C 2.6 3.0 5.1 -1.5 -0.2 -1.8 2.0 1.0 2.3 -1.7 2.1 1.9 -1.8
Knee pain experienced in last month 0.4 0.6 1.6 -1.3 0.7 -0.5 0.1 0.5 -0.7 -1.2 0.9 -0.7 -0.3
Hypertension (Self-reported) 1.1 2.9 8.0 2.8 2.6 -0.5 -0.6 -1.1 -1.8 2.5 -0.3 0.1 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.6 -1.0 -0.3 -0.8 -0.7 1.3 -0.3 -1.1 1.1 0.0 0.7
Illnesses of father: Heart disease 0.4 0.5 2.1 -1.0 -0.3 0.0 -0.4 1.5 -0.9 -0.8 0.4 -0.6 0.1
Illnesses of siblings: Diabetes 3.0 3.7 12.5 2.3 2.2 0.3 -0.8 -1.1 -1.6 2.3 -0.9 -1.8 3.5
Smoking status: Previous 0.3 0.5 1.7 -0.5 -0.4 -0.3 -0.5 1.3 -1.0 -0.6 1.0 0.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.8 0.8 0.9 -1.7 0.4 -0.7 -0.8 0.9 -1.1 -0.2 -0.4
Whole body fat-free mass 0.2 1.3 3.2 0.3 0.5 -0.5 1.8 -1.5 -1.8 0.2 -1.4 -1.1 0.9
Leg fat-free mass (right) 0.3 1.5 4.0 1.0 1.0 -0.6 2.0 -1.4 -1.6 0.8 -1.5 -0.8 0.6
Arm fat percentage (left) 1.0 3.8 8.2 2.9 2.4 0.3 0.7 -2.2 -1.8 2.6 -1.3 -2.0 2.0
Average weekly red wine intake 1.6 2.4 10.4 -1.8 -1.1 -0.4 0.8 2.1 1.2 -1.5 -0.1 0.8 -3.2
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.3 -0.3 -0.2 0.4 1.1 0.6 0.8 -0.5 0.4 1.0 -0.6
Mood swings 0.5 0.8 2.8 0.8 -0.1 1.4 -0.7 -0.7 0.0 0.8 -0.4 -1.0 1.7
Loneliness, isolation 0.3 0.4 2.2 -0.4 0.2 -0.6 1.5 0.7 0.1 -0.6 0.7 0.2 0.3
Long-standing illness, disability or infirmity 0.8 1.3 4.3 0.7 0.4 -0.3 1.1 -1.9 -2.1 0.7 -0.9 -1.0 -0.7
Ever had bowel cancer screening 2.6 3.1 8.9 -2.3 -2.2 1.8 3.0 -1.1 0.7 -2.3 1.0 -0.5 -0.4
Diabetes diagnosed by doctor 0.6 0.9 5.2 0.4 0.7 0.4 2.3 0.1 -0.7 0.3 0.5 -0.6 1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 5.4 -0.7 -1.2 -0.8 -1.5 1.1 -2.1 -0.6 -2.3 -1.2 -0.7
Friendships satisfaction 0.5 0.7 2.5 0.0 -1.0 -0.9 1.6 0.7 0.2 -0.2 -0.5 1.2 -0.4
Qualifications: nursing, teaching 0.4 0.6 3.2 -0.0 -0.3 0.4 0.0 -1.8 1.0 -0.2 -1.0 0.6 0.7
Commuting to job workplace: Walk 0.6 0.6 4.5 -0.4 -0.5 -2.1 0.2 0.8 -0.1 -0.4 -0.5 0.6 -0.1
Eye problems/disorders: Cataract 2.7 3.1 6.7 -2.1 -0.6 -0.3 2.6 1.5 1.8 -2.3 1.2 1.6 -2.2
Mouth/teeth dental problems: Mouth ulcers 3.1 5.0 14.2 3.8 3.4 0.1 -0.2 -1.1 -1.6 3.4 0.6 -0.7 2.7
Medication for cholesterol 0.3 0.5 1.6 -0.9 -0.5 0.1 -0.3 0.4 1.1 -0.7 1.2 -0.4 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.5 0.3 0.5 -0.8 -0.5 0.1 -1.2 -0.2 0.5 -0.2 0.7
Back pain experienced in last month 0.5 0.7 1.9 -0.7 -0.5 -0.9 -1.1 0.4 -1.4 -0.7 -0.1 -1.2 0.4
Mineral and other dietary supplements 1.4 1.9 4.8 2.2 0.1 -0.1 -1.4 -1.8 -0.1 1.8 -0.6 -0.8 2.2
Breast cancer (self-reported) 2.1 2.5 6.6 -0.3 -0.1 1.1 2.6 0.8 1.6 -0.2 2.2 2.3 -1.8
Asthma (self-reported) 0.6 1.2 3.0 1.0 0.4 0.3 -0.3 -1.5 -1.1 1.0 -1.3 -1.7 1.4
Osteoporosis (self-reported) 0.3 0.3 0.9 -0.2 -0.9 1.0 0.6 0.1 0.1 -0.5 0.6 0.6 0.5
Osteoarthritis (self-reported) 0.2 0.3 0.7 -0.8 -0.1 -0.5 0.8 -0.2 0.2 -0.7 0.3 -0.1 -0.7
Medication: Aspirin 0.8 1.1 3.9 0.8 1.6 0.2 0.5 -0.3 -1.2 0.8 -1.1 -2.0 0.6
Medication: Gliclazide 1.3 1.4 6.4 0.1 0.2 -2.3 -0.3 0.8 -2.5 -0.1 -0.1 -0.7 1.1
Illnesses of father: None of the above (group 1) 0.2 0.3 1.3 -0.2 0.1 -1.1 -0.6 0.2 -0.2 -0.4 0.1 0.3 -0.9
Smoking status: Current 0.2 0.4 0.9 0.5 -0.4 0.2 -0.6 0.2 0.9 0.7 -0.5 -0.7 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.2 15.5 -2.2 -1.7 -0.5 3.9 1.0 1.2 -2.3 1.4 1.9 -2.3
Whole body water mass 0.2 1.4 3.4 0.3 0.4 -0.6 1.9 -1.6 -1.8 0.2 -1.5 -1.0 0.8
Leg predicted mass (right) 0.3 1.4 3.9 1.0 0.9 -0.7 2.0 -1.4 -1.5 0.8 -1.5 -0.8 0.6
Arm fat mass (left) 0.9 3.8 7.3 2.7 2.4 -0.1 1.5 -2.2 -1.9 2.4 -1.2 -1.8 1.8
Number of self-reported non-cancer illnesses 1.4 2.4 5.2 1.9 1.6 -0.5 0.9 -1.9 -2.3 1.8 -1.1 -1.4 1.4
Average weekly champagne plus white wine intake 0.5 0.7 1.9 1.2 0.8 -1.2 0.6 -0.8 -0.0 1.4 -0.7 0.6 -0.0
Miserableness 1.2 2.1 8.9 1.3 1.2 0.1 -0.7 -0.5 -1.2 1.2 -1.0 -2.0 3.0
Guilty feelings 2.3 3.4 9.5 1.4 1.6 -2.0 -1.0 -0.2 -2.5 1.5 -0.8 -3.1 2.4
Wears glasses or contact lenses 0.5 0.5 1.8 -0.8 -0.5 -0.3 1.4 -0.3 -0.0 -1.1 0.6 0.9 -0.4
Ever taken oral contraceptive pill 0.9 1.0 3.5 -0.6 -1.1 1.1 -1.3 -1.9 0.2 -0.6 -1.0 -1.0 0.1
Hearing aid user 1.4 1.6 6.2 -2.5 -1.4 -0.1 -0.7 0.1 -0.1 -2.5 0.4 0.4 -0.7
Mother’s age at death 0.4 0.5 1.6 -1.0 0.5 -0.7 0.3 1.3 -0.3 -1.0 0.1 -0.6 0.0
Financial situation satisfaction 0.5 0.7 1.7 1.3 0.3 0.6 -1.0 -0.4 -1.0 0.8 -0.2 0.2 1.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.6 0.8 1.2 -0.6 0.3 0.2 -1.2 0.8 -0.8 -1.0 0.7
Commuting to job workplace: Public transport 0.6 0.7 2.4 1.5 0.5 -0.8 -0.6 -0.6 0.2 1.3 -1.0 -0.1 0.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.6 -0.8 -1.0 -1.3 0.9 -0.9 -0.5 -0.8 -1.1 -0.5 0.3
Medication: Blood pressure 0.8 1.4 3.5 1.6 1.3 -1.3 0.4 -1.0 -1.9 1.3 -1.2 0.7 0.5
Pain type(s) experienced in last month: Hip pain 1.3 1.6 6.0 0.2 0.8 0.4 -0.6 -1.7 -1.8 0.4 -1.6 -2.4 0.8
Supplements: Fish oil (including cod liver oil) 3.3 4.3 9.1 -2.6 -0.4 0.1 2.2 2.4 1.6 -2.5 2.1 2.0 -3.0
High cholesterol (Self-reported) 0.8 1.5 3.2 1.7 1.8 0.5 -1.0 0.1 -1.3 1.7 -0.4 -1.3 1.1
Medication: Bendroflumethiazide 0.6 0.8 2.7 -0.7 -0.3 -1.1 -0.3 1.6 -1.1 -0.9 0.2 0.8 -1.1
Medication: Paracetamol 0.6 1.0 4.8 -0.4 -0.6 0.7 2.2 -0.2 -0.7 -0.4 0.9 1.2 -1.0
Medication: Lisinopril 1.6 2.1 5.2 0.6 1.6 -0.9 0.2 2.0 0.7 0.6 2.3 2.1 -1.5
Medication: Atorvastatin 1.6 1.9 4.1 1.9 1.6 1.1 1.3 -1.2 -0.8 2.0 -1.3 -1.3 1.0
Illnesses of father: High blood pressure 0.7 0.8 2.1 0.9 1.2 0.2 1.4 -0.2 0.0 0.9 1.1 1.1 -0.7
Alcohol drinker status: Never 1.8 2.2 7.5 0.1 1.3 -2.1 -1.3 0.5 -2.0 0.5 -1.0 -2.7 1.1
Ever smoked 0.3 0.6 3.6 0.2 -0.5 1.1 -1.9 0.5 0.1 0.2 0.7 -0.0 0.1
Basal metabolic rate 0.3 1.6 3.5 0.8 0.8 -0.5 1.8 -1.6 -1.9 0.6 -1.4 -1.2 1.1
Leg fat percentage (left) 1.4 5.2 10.1 3.2 3.0 -0.3 0.4 -1.2 -2.9 2.8 -1.1 -2.1 3.1
Arm fat-free mass (left) 0.3 1.7 6.3 0.6 0.8 -0.6 1.5 -1.3 -2.5 0.4 -1.5 -1.2 1.2
Number of operations (self-reported) 0.9 1.4 3.0 0.5 0.7 -0.9 1.7 -1.6 -1.6 0.2 -1.1 -0.9 1.4
Average weekly beer plus cider intake 0.6 0.9 2.1 1.1 0.7 -0.8 0.6 1.2 0.2 0.8 1.1 1.4 0.7
Irritability 0.1 0.2 1.1 -0.1 -0.2 0.0 -0.2 0.6 0.3 -0.1 1.0 0.1 0.9
Risk taking 1.2 1.7 5.7 -0.1 -0.3 1.0 -0.4 -2.0 -1.7 -0.0 -2.4 -1.3 1.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 6.1 1.1 1.0 0.6 1.3 -2.5 -0.3 0.9 0.0 -0.5 0.3
Fractured/broken bones in last 5 years 1.1 1.4 3.4 -1.2 -1.8 1.9 0.8 0.8 0.5 -0.8 -1.2 0.4 -1.7
Age started oral contraceptive pill 0.2 0.3 1.1 -0.5 0.4 -0.8 -0.1 -1.0 0.5 -0.5 -0.3 -0.2 0.5
Diastolic blood pressure, automated reading 0.2 0.7 2.5 1.1 -0.0 -0.8 -0.1 -0.5 -1.6 0.8 -1.2 -0.2 0.5
Ever depressed for a whole week 1.8 2.2 12.5 -0.4 -0.2 1.4 1.3 1.2 1.2 -0.3 3.5 1.5 -0.5
Unable to work because of sickness or disability 0.6 0.8 4.4 -0.7 -0.3 -0.4 -0.3 0.4 1.0 -0.6 0.8 0.7 -2.1
Commuting to job workplace: Cycle 0.4 0.5 2.2 0.4 0.3 0.7 -1.2 0.3 0.0 0.5 -0.5 -0.5 1.5
Myopia 0.3 0.5 1.7 -0.7 -0.3 -0.8 0.5 0.4 -1.0 -0.7 -1.3 0.0 -0.3
Vascular/heart problems diagnosed by doctor 1.3 3.5 7.2 -2.7 -2.6 0.2 0.7 1.9 2.2 -2.5 1.2 0.7 -1.9
Cholesterol lowering medication 1.2 1.8 3.8 1.9 0.6 1.0 -0.3 -1.3 -1.1 1.6 -1.4 -1.4 1.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 8.3 0.5 0.2 -0.6 1.5 -2.9 0.0 0.8 -0.5 -0.5 -0.1
Pain experienced in last month 0.7 1.2 3.7 1.9 1.1 -0.2 0.6 0.1 1.0 1.9 -1.1 0.8 0.4
Supplements: Calcium 1.1 1.2 3.2 -1.8 -0.9 0.6 0.0 0.8 -1.4 -1.5 -0.6 -0.5 -1.4
Basal cell carcinoma (self-reported) 0.6 0.8 3.6 0.4 0.2 -0.6 -0.7 -0.7 0.0 0.1 -0.9 -1.2 1.9
Heart attack/myocardial infarction (self-reported) 1.0 1.3 5.3 1.4 2.3 0.1 0.1 -0.2 -0.8 1.4 -0.5 -1.6 0.6
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 3.8 0.6 0.3 -1.9 0.4 -0.4 1.2 0.3 -0.4 0.2 -0.2
Heart disease (siblings) 2.1 2.6 6.2 2.4 1.2 1.6 -0.8 -0.5 -1.8 2.5 -1.6 -1.3 1.2
Alcohol drinker status: Previous 0.4 0.5 1.7 -0.6 -1.1 0.7 0.3 -0.4 -0.6 -0.5 -0.6 -1.3 -0.1
Pack years of smoking 0.6 0.9 2.1 1.3 1.2 0.3 -0.4 -0.8 0.4 1.4 1.0 0.3 1.4
Impedance of whole body 0.3 1.7 9.3 0.6 0.2 -0.6 -3.0 1.1 1.5 0.6 1.5 0.8 0.0
Leg fat mass (left) 1.3 4.9 9.4 3.1 3.0 -0.5 1.3 -1.8 -2.7 2.7 -1.1 -1.9 2.6
Arm predicted mass (left) 0.4 1.9 5.7 0.8 0.9 -0.4 1.9 -1.6 -2.4 0.6 -1.5 -1.2 1.2