TWAS hub - CEPT1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0220	6.3e-03	0.010	0.007	-0.001	0.006	0.006	1.8e-02	4.2e-02	4.1e-01	5.6e-02	5.6e-02
2	GTEx	Cells Transformed fibroblasts	0.3770	0.0630	5.2e-12	0.270	NA	0.305	NA	0.312	2.1e-20	NA	3.2e-23	NA	7.7e-24
3	METSIM	Adipose	0.1840	0.0416	8.5e-10	0.162	0.072	0.160	0.147	0.170	1.5e-23	6.9e-11	2.7e-23	2.1e-21	1.2e-24
4	YFS	Blood	0.0685	0.0169	8.9e-10	0.031	0.034	0.046	0.051	0.049	2.2e-10	2.8e-11	1.1e-14	3.7e-16	1.1e-15
5	TCGA	Breast Invasive Carcinoma	0.0156	0.0082	8.8e-03	0.007	0.010	0.007	NA	0.009	9.3e-03	3.0e-03	1.3e-02	NA	5.5e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0331	0.0169	3.9e-03	0.029	0.020	0.003	NA	0.015	2.6e-04	2.2e-03	1.2e-01	NA	7.8e-03
7	TCGA	Prostate Adenocarcinoma	0.0372	0.0203	9.4e-03	0.030	0.010	0.030	NA	0.028	4.0e-04	2.5e-02	4.0e-04	NA	5.9e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FEV1/FVC ratio	5.5	28.1	72.9	-1.4	8.1	8.5	1.4	-2.2	-6.6	-2.3
Number of treatments/medications taken	3.8	6.8	17.7	-3.0	-1.3	-1.3	-1.0	-2.3	-4.2	-3.4
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	12.9	-2.1	-0.7	-0.2	-0.3	-1.2	-2.9	-3.6
Risk taking	3.4	5.0	9.0	-3.0	-3.0	-3.0	-0.9	-1.1	-1.1	-2.2
Number of live births	3.0	4.2	9.3	2.2	3.1	3.0	1.3	1.4	1.0	1.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	7.8	-0.7	-0.8	-0.5	-2.0	-2.8	-2.2	-1.8
Glaucoma (self-reported)	2.9	3.4	7.3	-0.8	-1.6	-1.4	-1.3	-2.4	-2.1	-2.7
Qualifications: None of the above	2.8	6.1	14.4	2.7	1.9	1.5	1.5	2.1	2.9	3.8
Depression (self-reported)	2.8	3.3	7.4	0.7	2.7	2.4	1.3	2.0	0.7	1.9
Average weekly beer plus cider intake	2.6	3.8	6.2	2.0	1.3	1.1	1.6	2.5	2.4	2.1
Ulcerative Colitis	2.5	3.6	8.1	2.1	2.0	1.6	1.0	1.0	2.0	2.8
Diabetes (mother)	2.3	2.9	5.6	-0.1	-1.2	-1.5	-1.6	-1.9	-2.4	-2.3
Alcohol intake versus 10 years previously	2.3	3.5	5.3	1.4	2.3	2.0	1.3	1.7	1.9	2.2
Medication for pain relief, constipation, heartburn	2.3	3.8	7.9	2.8	1.1	1.1	0.2	2.1	2.6	2.3
Illnesses of mother	2.2	2.7	4.8	1.0	1.7	2.2	0.5	1.6	1.8	2.1
Irritable Bowel Disease (IBD)	2.1	5.0	12.0	0.1	3.2	2.7	1.3	0.3	1.7	3.5
Major Depression (MDD)	2.1	2.6	3.6	1.3	1.9	1.5	1.3	1.9	1.4	1.8
Average weekly spirits intake	2.1	2.6	6.1	1.4	0.6	0.2	1.6	2.5	1.9	1.8
Medication: Atorvastatin	2.1	2.6	5.5	-2.3	-1.2	-1.3	-0.7	-1.3	-2.0	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	20.1	0.9	4.5	4.5	-0.1	-0.2	-1.6	0.8
Medication: Ventolin 100micrograms inhaler	2.0	2.5	7.6	1.4	0.8	0.9	-0.7	1.5	2.8	2.0
Heart disease (mother)	2.0	2.5	6.4	-0.9	-1.5	-1.5	-0.3	-1.4	-1.9	-2.5
Illnesses of father: High blood pressure	2.0	2.5	4.9	-1.0	-1.1	-1.0	-1.1	-2.2	-2.0	-1.9
Crohns Disease (2012)	1.8	3.0	7.9	-0.7	2.7	2.8	1.2	1.0	0.4	1.6
Hair/balding pattern: Pattern 2	1.8	2.3	5.7	1.5	0.5	0.6	2.4	2.2	1.5	0.7
Number of full sisters	1.8	2.1	5.0	0.2	2.2	2.1	0.3	0.4	0.9	2.1
Blood White Count	1.7	12.5	28.4	3.2	1.7	0.9	1.4	4.4	5.3	4.8
Medication: Ibuprofen	1.7	2.0	7.0	-2.7	-0.5	-0.1	-1.0	-2.0	-1.2	-0.5
Family relationship satisfaction	1.7	2.1	3.6	-1.6	1.9	1.7	-0.8	-1.3	-1.9	-0.3
Commuting to job workplace: Walk	1.7	1.9	6.1	-0.8	-0.2	-0.2	-1.7	-2.5	-1.7	-0.8
Mineral and other dietary supplements	1.7	2.2	6.6	0.2	-2.6	-2.4	-0.5	-0.3	0.1	-1.7
Medication: Paracetamol	1.7	2.7	6.5	-1.7	-0.7	-0.7	-0.3	-1.8	-2.5	-2.3
Blood Platelet Count	1.6	19.1	60.7	0.9	-7.0	-7.8	-1.5	2.2	3.8	1.2
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	5.5	-2.4	0.5	0.2	-0.9	-0.5	-2.1	-1.0
Diverticular disease/diverticulitis (self-reported)	1.6	2.0	5.3	2.3	1.5	1.4	1.6	0.5	0.6	1.1
Chronic bronchitis/emphysema (father)	1.6	1.9	5.4	1.6	-0.1	-0.4	0.7	1.2	2.3	1.8
Cholesterol lowering medication	1.6	2.3	4.5	-2.1	-1.9	-1.7	-0.2	-0.2	-1.1	-2.0
Crohns Disease (2017)	1.5	3.3	9.5	-0.5	3.1	2.9	1.3	0.2	0.3	1.9
Primary Biliary Cirrhosis	1.5	2.1	6.4	0.1	-2.5	-2.5	-0.1	0.5	0.0	-1.3
Number of incorrect matches in round	1.5	2.5	6.3	0.2	2.5	2.2	1.8	1.3	0.8	1.1
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	16.1	1.2	4.0	4.0	-0.1	-0.3	-1.4	0.7
Worry too long after embarrassment	1.5	2.4	5.0	1.8	2.1	1.8	1.0	0.5	0.3	2.2
Eye problems/disorders: None of the above	1.5	1.7	5.1	2.3	0.4	0.4	-0.7	0.2	1.6	1.9
Osteoporosis (self-reported)	1.5	1.9	4.6	-0.4	2.1	2.1	-0.8	-1.3	-0.1	1.3
Worry (Nagel 2018)	1.4	2.9	8.8	1.8	1.6	1.2	1.0	0.9	1.7	3.0
HDL Cholesterol	1.4	2.4	6.6	-2.6	-0.7	-0.5	-1.2	-1.7	-1.7	-1.4
Medication: Co-codamol	1.4	1.6	3.0	1.0	1.7	1.7	-0.8	0.3	0.8	1.7
Peak expiratory flow (PEF)	1.4	3.2	8.9	1.0	3.0	2.8	-0.3	-0.4	-2.0	0.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	8.9	-2.1	1.0	1.1	-0.5	-1.2	-3.0	-1.5
Eye problems/disorders: Cataract	1.4	1.7	5.0	-2.2	-0.5	-0.3	-0.2	-1.0	-1.7	-1.6
Basal cell carcinoma (self-reported)	1.4	1.7	4.5	-1.4	-2.1	-1.9	-0.6	0.0	0.3	-1.1
Prostate Cancer	1.3	1.8	4.2	-0.0	-1.7	-2.1	1.9	0.9	0.2	-0.7
Hypothyroidism (self reported)	1.3	2.9	8.9	-3.0	0.7	0.9	-0.3	-0.5	-2.8	-1.5
Pain all over the body in last month	1.3	1.4	4.8	-0.5	2.0	2.2	0.2	-0.5	0.3	0.9
Medication: Ramipril	1.3	1.6	3.3	-1.4	-1.2	-1.2	-1.0	-0.3	-1.8	-1.5
Medication: Seretide 50 evohaler	1.3	1.4	2.9	-0.7	-1.7	-1.3	-0.6	-1.7	-0.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.2	-0.1	-0.6	-0.5	-0.5	-1.2	-2.0	-1.8
Friendships satisfaction	1.3	1.6	4.8	1.3	2.2	2.0	0.1	0.3	-0.5	0.8
Mother’s age at death	1.3	1.6	4.6	-1.8	0.2	0.2	0.1	-1.3	-2.1	-1.3
Eye problems/disorders: Glaucoma	1.3	1.6	3.8	-0.2	-1.4	-1.3	-0.4	-1.2	-1.5	-1.9
Medication: Blood pressure	1.3	2.5	5.6	-1.4	-1.8	-1.9	0.3	-0.6	-1.6	-2.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	5.6	0.1	2.4	2.0	0.7	0.3	-0.5	1.2
Ever depressed for a whole week	1.3	1.7	5.6	-0.6	-0.6	-0.3	-0.9	-2.4	-1.7	-1.3
Reaction Time	1.2	2.3	7.0	1.0	2.2	2.6	1.1	0.6	1.1	0.6
Waist Hip Ratio (WHR)	1.2	5.2	19.4	-0.3	-3.8	-4.4	1.1	0.9	0.2	-0.9
Supplements: Zinc	1.2	1.3	4.5	-0.4	1.9	2.1	0.0	0.2	0.2	0.8
Taking other prescription medications	1.2	1.9	5.2	-2.3	0.5	0.5	-1.4	-1.6	-1.7	-0.6
Alcohol usually taken with meals	1.2	2.0	3.3	-1.0	-1.8	-1.4	-1.6	-1.3	-1.1	-1.5
Falls in the last year	1.2	1.6	4.6	-2.1	-1.2	-1.1	-0.8	-1.4	-0.9	-1.0
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	4.6	-2.1	-1.9	-1.4	-0.4	-0.6	-0.6	-1.5
Comparative body size at age 10	1.2	3.4	6.2	-2.1	-2.5	-2.5	-0.5	-0.8	-1.3	-2.1
Medication: Aspirin	1.2	1.5	4.2	-2.0	-0.7	-0.5	-0.5	-0.6	-1.6	-1.6
Medication: Gliclazide	1.2	1.3	2.2	-1.4	1.3	0.9	-0.7	-1.5	-1.2	0.8
Number of self-reported non-cancer illnesses	1.2	2.2	5.4	-1.6	-0.9	-1.0	-0.6	-1.2	-2.3	-1.9
High cholesterol (Self-reported)	1.2	2.2	3.5	-1.3	-1.8	-1.9	-0.3	-1.0	-1.7	-1.7
Myopia	1.2	1.8	3.0	-1.7	-0.1	0.4	-1.4	-1.7	-1.6	-1.4
Pain experienced in last month	1.2	2.0	5.0	2.2	1.3	1.2	0.9	2.2	0.4	0.0
Alzheimer’s Disease (in father)	1.1	1.2	3.5	-1.9	1.3	1.6	0.5	-0.1	-0.0	0.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.9	0.5	1.7	1.6	1.1	0.3	0.9	1.6
Had other major operations	1.1	1.3	3.5	-1.9	1.1	1.1	-0.9	-1.0	-1.2	-0.4
Medication: Paracetamol	1.1	1.8	4.5	-1.3	-0.6	-1.0	0.8	-1.1	-2.1	-1.8
Headache pain in last month	1.1	1.9	5.3	-1.6	-1.4	-1.6	-0.7	-2.3	-0.5	-0.7
Wheeze or whistling in the chest in last year	1.1	2.0	4.9	-2.2	-1.6	-1.6	-1.2	-0.2	-0.7	-1.2
Leg pain on walking	1.1	1.3	3.9	-2.0	-1.7	-1.0	0.1	-0.5	-0.2	-1.1
Medication: Aspirin	1.1	1.4	3.1	-1.8	-1.0	-0.8	-0.5	-0.6	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	7.8	0.8	2.8	2.6	1.2	0.1	-0.4	0.6
Supplements: Calcium	1.1	1.3	3.1	-1.8	1.3	1.5	-1.0	-0.3	-0.3	0.7
Bipolar Disorder or Schizophrenia	1.0	2.6	6.0	0.1	1.8	1.6	0.6	1.6	1.7	2.4
Neuroticism (Nagel 2018)	1.0	2.3	7.1	1.2	1.9	1.3	1.0	0.7	1.1	2.7
Ulcerative Colitis (UC)	1.0	1.9	6.5	0.3	1.7	1.2	0.5	-0.1	1.4	2.5
LDL Cholesterol	1.0	1.6	4.5	0.7	2.1	1.9	0.3	0.2	-0.1	1.5
Fed-up feelings	1.0	1.9	5.9	1.2	1.1	0.5	1.7	0.8	1.0	2.4
High blood pressure	1.0	2.7	5.2	-0.5	-1.9	-2.3	-0.8	-1.1	-2.0	-2.0
Medication: Levothyroxine sodium	1.0	1.8	4.2	-1.4	1.3	1.4	-0.8	-1.2	-2.0	-0.7
Nervous feelings	1.0	1.8	4.7	0.7	1.8	1.7	0.5	-0.0	1.2	2.2
Neuroticism score	1.0	2.0	7.5	0.2	1.1	0.7	1.0	0.8	1.8	2.7
Medication: Cholesterol lowering	1.0	1.6	3.6	-0.8	-1.3	-1.6	-0.9	-0.8	-1.9	-1.2
Medication: Lansoprazole	1.0	1.1	3.4	-0.2	1.9	1.4	-0.1	0.5	0.2	1.4
Migraine (self-reported)	1.0	1.2	3.4	0.1	0.1	-0.3	1.4	1.8	1.4	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.0	-0.8	-0.8	-0.8	-1.2	-1.4	-1.1	-1.3
Ever taken oral contraceptive pill	1.0	1.1	2.9	1.7	-0.6	-0.4	-1.3	-0.0	1.6	0.7
Vascular/heart problems diagnosed by doctor	1.0	2.8	5.6	0.3	2.0	2.4	0.7	0.9	2.0	2.1
Schizophrenia (2014)	0.9	2.1	4.6	0.0	2.1	1.9	0.8	1.1	1.0	1.9
Severe depression (siblings)	0.9	1.0	1.7	0.8	1.1	1.3	0.9	0.9	0.8	1.1
High blood pressure (mother)	0.9	1.2	2.6	-1.5	-0.8	-1.2	-0.3	-0.8	-1.6	-1.0
Medication: Simvastatin	0.9	1.3	3.4	-0.3	-1.1	-1.2	-0.1	0.2	-1.8	-1.7
Worrier / anxious feelings	0.9	1.8	4.1	1.5	0.3	0.2	1.5	0.7	1.8	2.0
Exposure to tobacco smoke at home	0.9	1.0	2.7	-0.7	-0.2	-0.4	-1.3	-1.0	-1.6	-0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	3.7	1.1	1.1	1.3	0.8	0.7	1.9	1.1
Forced vital capacity (FVC), Best measure	0.9	3.2	9.1	1.1	3.0	3.0	0.0	0.6	0.3	1.8
Exposure to tobacco smoke outside home	0.9	1.1	3.2	1.1	-0.8	-0.9	-0.9	-1.8	-1.0	-0.6
Number of full brothers	0.9	1.1	4.5	2.1	0.5	0.2	0.7	1.0	0.9	0.8
Health satisfaction	0.9	1.2	4.7	-2.2	-0.3	-0.3	-0.8	-1.0	0.8	1.0
Pulse rate, automated reading	0.9	3.0	9.4	0.0	1.4	0.7	1.2	1.6	2.3	3.1
Had major operations	0.9	1.0	2.6	-1.6	-0.9	-0.7	-0.7	-1.1	-0.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.6	-0.3	-1.2	-1.6	0.2	0.1	-1.6	-0.8
Ever had bowel cancer screening	0.9	1.1	3.0	-1.7	0.7	0.9	-0.1	-0.9	-1.2	-1.0
Pain type(s) experienced in last month: Hip pain	0.9	1.2	4.0	-2.0	-0.5	-0.1	-1.3	-1.5	-0.1	0.0
Number of operations (self-reported)	0.9	1.3	5.1	-2.2	-0.3	-0.5	-0.5	-1.4	-1.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.2	0.2	-1.1	-1.0	1.5	1.4	0.9	-0.5
Bipolar Disorder (2018)	0.8	1.3	2.3	0.4	1.5	1.4	-0.4	1.1	1.0	1.5
Breast Cancer	0.8	1.8	6.4	0.1	1.0	0.8	0.9	2.5	1.5	1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.8	0.6	1.7	1.6	-0.3	0.6	0.9	0.9
Mean Putamen Volume	0.8	0.9	4.1	0.9	0.2	-0.3	0.2	-0.4	-2.0	-1.1
Fasting Glucose	0.8	1.0	2.8	1.7	1.1	1.0	-0.2	-0.5	0.4	1.2
Sensitivity / hurt feelings	0.8	1.4	3.8	-0.4	0.9	0.7	0.9	0.9	1.7	2.0
Diabetes (father)	0.8	1.1	3.0	1.7	1.3	1.1	0.4	1.0	0.3	0.5
Maternal smoking around birth	0.8	1.2	3.0	0.2	-0.3	-0.0	-1.7	-1.7	-1.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.7	-1.0	-0.4	-0.7	0.5	1.6	1.2	0.8
Serious illness, injury or assault to yourself	0.8	1.0	2.3	-1.1	-0.1	0.1	-1.1	-1.5	-1.2	-0.7
Medication: Atenolol	0.8	1.0	1.9	-0.8	-0.7	-1.1	0.8	0.9	-1.2	-1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	-1.6	0.4	0.7	-0.4	-1.6	-0.8	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.6	-2.2	0.0	0.4	-0.4	-1.4	-0.6	-0.0
Pulse wave reflection index	0.8	1.0	2.7	-1.2	0.6	0.7	-0.4	-1.6	-1.3	-0.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.5	1.1	1.6	1.4	0.4	-0.0	0.0	0.6
Loneliness, isolation	0.8	1.1	2.0	-0.4	0.7	0.5	1.4	1.4	1.4	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.5	0.5	1.4	1.6	0.0	0.7	0.8	0.8
Depressed Affect (Nagel 2018)	0.7	1.4	5.1	0.8	0.8	0.1	1.1	0.6	1.2	2.3
Schizophrenia (2018)	0.7	1.5	3.6	-0.2	1.1	0.9	1.1	1.2	1.4	1.9
Lupus	0.7	1.1	3.1	-1.0	-1.8	-1.5	-0.4	-1.1	0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.2	1.8	-0.8	-0.9	1.0	0.0	0.1	-0.1
Vitamin and mineral supplements	0.7	0.9	3.0	0.1	-1.7	-1.7	-0.2	-0.5	0.3	-0.5
Stomach or abdominal pain in last month	0.7	0.8	2.0	-0.2	-0.6	-0.7	0.8	1.0	1.4	1.1
Heart attack	0.7	0.9	3.1	-0.3	-1.0	-1.2	0.5	1.8	0.7	-0.1
Neck or shoulder pain in last month	0.7	1.0	3.7	-1.3	-0.3	-0.2	-0.9	-1.9	-0.4	0.9
Hypertension (Self-reported)	0.7	1.9	3.8	-0.5	-1.5	-1.9	-0.5	-0.7	-1.9	-1.6
Average weekly red wine intake	0.7	1.0	4.0	-0.1	0.6	0.5	0.2	-1.1	-2.0	-0.9
Long-standing illness, disability or infirmity	0.7	1.1	2.1	-1.1	1.2	1.4	-0.8	-0.5	0.4	1.4
Diabetes diagnosed by doctor	0.7	1.2	4.5	-2.1	1.3	0.8	0.1	-0.3	-1.3	0.1
Qualifications: nursing, teaching	0.7	1.0	2.5	1.3	-0.5	-0.6	-0.0	1.3	1.6	0.9
Guilty feelings	0.7	1.0	5.6	-2.4	0.2	-0.1	-0.2	-0.3	0.3	1.1
Irritability	0.7	1.2	3.1	-1.2	-0.8	-1.0	-1.2	-1.8	-1.1	-0.3
Heart disease (siblings)	0.7	0.9	1.9	-0.7	-0.2	-0.2	-0.9	-1.1	-1.4	-1.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.6	-2.1	-1.2	-0.7	-0.7	-1.2	-1.3	-1.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.9	-1.2	1.4	1.7	0.4	0.2	-0.4	-0.1
Ovarian Cancer	0.6	0.8	2.5	-1.6	-0.5	0.3	-0.7	0.2	-0.7	-1.3
Blood Red Count	0.6	5.5	11.0	2.2	0.6	0.0	2.7	2.9	3.3	2.7
Lung FVC	0.6	3.0	7.7	1.5	2.8	2.8	0.4	1.1	0.6	1.3
Angina	0.6	0.8	1.6	-0.6	-0.9	-1.0	0.2	1.3	-0.8	-1.0
Medication: Metformin	0.6	0.8	3.8	-2.0	0.7	0.2	-0.6	-0.7	-0.9	-0.0
Age when periods started (menarche)	0.6	1.4	4.7	-2.2	0.9	1.2	-1.0	-1.1	-1.0	-0.1
Multivitamins +/- minerals	0.6	0.7	1.5	-0.9	1.2	1.2	0.5	1.1	-0.1	0.1
Forced vital capacity (FVC)	0.6	2.2	5.7	1.5	2.4	2.3	-0.7	0.1	0.1	1.3
Diabetes (self-reported)	0.6	0.9	2.2	-1.5	1.3	0.8	-0.4	-0.3	-1.3	-0.1
Happiness	0.6	0.7	1.3	0.1	1.1	1.0	-0.7	-1.0	0.1	1.0
Qualifications: College or University degree	0.6	1.9	5.9	-0.1	0.3	0.9	-1.0	-1.3	-1.9	-2.4
Mean time to correctly identify matches	0.6	1.1	3.3	0.3	1.6	1.8	1.1	0.2	0.6	0.4
Chest pain or discomfort	0.6	0.9	1.5	-1.1	-1.2	-1.1	-1.1	-0.8	0.7	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.3	0.6	0.2	0.3	0.4	0.7	1.4	1.5
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.4	-0.0	-0.5	-0.5	-1.3	-0.8	-1.6	-1.4
Breast cancer (self-reported)	0.6	0.7	3.5	-0.3	0.6	0.4	1.9	0.9	0.4	-0.3
Miserableness	0.6	1.0	3.3	0.3	1.3	1.1	0.2	0.1	1.0	1.8
Wears glasses or contact lenses	0.6	0.7	2.3	-1.5	-0.2	0.0	0.3	1.1	1.2	0.2
Hearing aid user	0.6	0.7	2.4	0.5	-0.1	-0.4	-0.5	0.0	1.3	1.5
Commuting to job workplace: Public transport	0.6	0.7	1.6	1.0	1.2	1.0	-0.0	0.2	0.0	1.1
Diastolic blood pressure, automated reading	0.6	1.9	3.8	-1.0	-1.4	-2.0	-0.7	-1.3	-1.6	-1.2
Unable to work because of sickness or disability	0.6	0.8	1.7	0.6	1.1	1.3	-0.6	-1.0	-0.2	0.8
Commuting to job workplace: Cycle	0.6	0.7	1.8	-0.7	-0.1	0.2	-1.0	-1.1	-1.3	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.1	-0.3	-0.8	-0.9	0.4	1.8	0.7	-0.0
Bipolar Disorder (2011)	0.5	0.4	0.7	-0.0	0.8	0.6	0.8	0.8	0.6	0.6
Triglycerides	0.5	0.8	1.8	0.8	0.5	0.5	0.8	1.3	1.0	0.8
Cardiovascular Disease	0.5	1.8	4.1	-0.5	-1.2	-1.3	-1.2	-1.5	-2.0	-1.2
Respiratory disease	0.5	1.1	2.6	-0.6	-1.3	-1.6	0.5	0.9	1.4	0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.2	-1.8	1.3	0.8	-0.2	-0.1	-0.5	0.5
Neuroticism	0.5	1.3	5.1	0.1	1.0	0.4	0.3	1.1	1.1	2.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.1	-1.5	-0.6	-0.6	-0.8	-0.9	-0.4	0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-1.1	-1.0	-0.9	-0.5	0.6	0.5	0.4
Current tobacco smoking	0.5	0.8	1.9	0.3	1.3	1.4	0.9	-0.3	0.3	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.4	0.5	1.1	0.9	-0.1	-1.2	-0.2	1.1
Father’s age at death	0.5	0.7	1.6	-1.2	-0.4	-0.0	-1.1	-0.9	-0.3	-0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	-1.1	-0.6	-0.5	-0.6	-1.1	-0.6	-1.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.0	1.0	0.9	0.2	0.5	0.7	1.3
Length of working week for main job	0.5	0.6	1.1	0.4	-0.5	-1.0	-0.5	-0.6	-1.0	-0.9
Tense / ‘highly strung’	0.5	0.8	2.7	0.2	1.0	1.0	-0.2	-1.0	0.2	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.0	0.3	0.8	0.7	0.1	-0.4	0.9	1.4
Medication: Amlodipine	0.5	0.7	3.8	0.3	-0.1	-0.5	1.9	0.8	-0.0	-0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.0	-1.7	-0.4	-0.5	0.6	0.1	0.7	0.2
Pulse wave peak to peak time	0.5	0.6	1.6	0.0	-1.1	-0.9	-0.3	-0.5	-0.7	-1.3
Angina (self-reported)	0.5	0.7	1.9	-0.5	-0.5	-0.7	0.4	1.4	-0.8	-0.9
Smoking status: Previous	0.5	0.8	1.2	-0.3	-0.9	-1.1	-0.9	-1.1	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.0	0.7	1.1	0.8	0.9	0.9	0.8	1.4
Asthma (self-reported)	0.5	1.0	2.0	-1.0	-1.3	-1.4	-0.7	0.3	1.2	0.1
Medication: Bendroflumethiazide	0.5	0.8	1.6	0.9	1.0	1.0	1.1	1.3	0.0	-0.2
Fractured/broken bones in last 5 years	0.5	0.6	1.0	0.8	0.9	0.9	1.0	-0.2	0.7	0.9
Neuroticism (2016)	0.4	0.5	1.4	0.3	0.1	-0.4	1.1	0.6	0.5	1.2
Smoking Status	0.4	0.9	2.7	-0.5	-0.7	-0.8	-1.2	-1.6	-0.9	-0.2
Sitting height	0.4	2.5	6.3	0.7	1.6	1.7	-0.1	1.1	2.1	2.5
Past tobacco smoking	0.4	0.8	2.0	0.0	1.4	1.4	0.6	0.8	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.2	0.8	1.3	0.9	0.6	-0.1	-1.5	-0.3
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.8	0.3	1.3	1.3	-0.2	0.1	-0.3	-0.0
Impedance of arm (right)	0.4	1.9	9.5	3.1	-0.4	-0.4	0.4	0.9	1.4	0.7
Noisy workplace	0.4	0.5	2.0	-1.4	-0.5	-0.5	0.0	-0.7	-0.8	-0.2
Asthma	0.4	0.7	1.3	-0.9	-1.0	-1.1	-0.7	0.3	1.2	0.1
Lung cancer (father)	0.4	0.4	1.0	-0.2	0.9	0.9	-0.3	-0.2	0.5	1.0
Impedance of arm (left)	0.4	1.8	8.9	3.0	-0.5	-0.5	0.3	0.7	1.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.6	0.5	1.1	0.9	0.7	-1.3	-0.6	0.3
Loud music exposure frequency	0.4	0.4	1.7	1.3	-0.3	-0.3	0.8	-0.2	-0.3	0.1
High blood pressure (siblings)	0.4	0.6	3.7	1.9	0.1	0.0	-0.1	0.4	0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.2	0.1	0.3	0.1	1.5	0.6	0.0	0.6
Emphysema/chronic bronchitis	0.4	0.4	0.9	0.5	-0.7	-0.9	0.7	0.9	0.2	0.0
Suffer from ‘nerves’	0.4	0.7	1.5	0.7	1.0	0.5	1.2	-0.0	-0.4	1.2
Overall health rating	0.4	0.9	3.3	-0.1	1.1	0.9	-0.2	0.1	0.8	1.8
Age at last live birth	0.4	0.6	1.7	1.3	0.6	0.7	0.4	0.7	0.7	0.9
Knee pain experienced in last month	0.4	0.6	1.4	-1.2	-0.2	-0.1	-1.1	-1.0	0.0	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.7	1.3	0.8	0.8	-0.0	0.5	-0.0	0.4
Mood swings	0.4	0.7	2.2	0.7	0.3	0.0	0.7	-0.2	1.3	1.5
Medication for cholesterol	0.4	0.6	1.8	1.1	0.6	0.7	-0.2	-0.3	0.8	1.3
Smoking status: Current	0.4	0.6	1.3	0.3	1.0	1.1	1.1	-0.1	0.2	0.7
Age started oral contraceptive pill	0.4	0.5	1.2	-1.1	-1.1	-0.9	0.1	0.5	-0.1	-0.5
Impedance of whole body	0.4	2.2	9.5	3.1	-0.7	-0.9	0.5	0.9	1.6	1.0
Depression (Nagel 2018)	0.3	0.5	1.9	0.2	0.7	0.5	-0.4	-1.4	-0.5	0.6
Schizophrenia vs Biploar Disorder	0.3	0.3	1.3	-0.7	0.1	0.1	0.2	-1.1	-0.6	-0.4
Age at First Birth	0.3	0.5	1.1	-0.7	0.7	1.0	-0.8	-0.9	-0.2	-0.1
Rheumatoid Arthritis	0.3	0.4	2.4	1.6	0.4	0.2	-0.1	-0.2	-0.3	0.2
Blood Eosinophil Count	0.3	2.7	7.6	-0.1	-2.8	-2.4	-1.4	-0.4	-0.6	-1.8
Chronotype (morning person)	0.3	0.8	3.4	1.4	-0.2	-0.2	-1.8	-0.2	0.3	0.4
Hand grip strength (left)	0.3	0.9	2.2	0.4	0.4	0.7	-1.5	-1.3	-1.2	-0.6
Hearing difficulty/problems: Yes	0.3	0.5	1.2	0.3	0.4	0.4	0.3	0.9	0.8	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.9	-0.5	-0.4	-0.6	-0.0	-0.4	-0.9
Medication for hormone replacement therapy	0.3	0.4	0.7	0.1	0.8	0.5	-0.2	0.6	0.8	0.8
Impedance of leg (right)	0.3	1.3	4.8	2.2	-0.3	-0.8	0.5	1.1	0.9	1.3
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.1	-0.7	-0.7	-0.9	-0.7	0.5	0.5
Impedance of leg (left)	0.3	1.4	5.6	2.4	-0.4	-0.8	0.6	1.0	0.9	1.1
Waist circumference	0.3	1.1	2.7	-1.6	-1.4	-1.6	-0.5	0.0	0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	1.1	0.6	0.2	1.1	-0.1	-0.3	0.9
Time employed in main current job	0.3	0.3	0.6	-0.1	0.4	0.7	-0.7	-0.6	-0.6	-0.3
Pulse rate	0.3	0.5	1.3	-0.7	0.4	0.2	-0.0	0.4	1.1	1.2
Mouth/teeth dental problems: Dentures	0.3	0.5	1.5	-0.6	0.8	0.6	-1.2	0.0	0.2	0.8
Prospective memory result	0.3	0.4	1.0	0.8	-0.5	-1.0	0.8	0.2	0.2	0.4
Breastfed as a baby	0.3	0.4	0.8	-0.6	-0.9	-0.8	0.0	0.7	0.5	0.0
Birth weight of first child	0.3	0.6	2.0	1.0	-0.1	-0.0	1.4	0.9	0.0	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.9	0.5	-0.3	-0.4	-0.9	-0.3	1.0	0.5
Leg fat percentage (right)	0.3	1.2	2.5	-1.6	-1.2	-1.5	-0.7	-0.5	-0.9	-0.8
Number of children fathered	0.3	0.3	1.2	-1.1	0.3	0.8	-0.5	0.0	-0.0	-0.0
Shortness of breath walking on level ground	0.3	0.3	1.1	-0.5	-1.0	-0.6	-0.4	-0.5	0.1	-0.4
Medication: Allopurinol	0.3	0.5	0.9	0.9	0.1	0.3	-0.3	0.7	0.9	1.0
Medication: Omeprazole	0.3	0.4	0.9	0.3	-0.7	-0.5	0.9	0.6	0.2	-1.0
Comparative height size at age 10	0.3	1.9	6.2	-0.7	2.5	2.4	-0.0	0.3	-0.4	0.6
Supplements: Vitamin C	0.3	0.4	1.0	-0.2	1.0	0.9	0.7	0.6	0.0	0.4
Back pain experienced in last month	0.3	0.4	0.8	-0.8	0.5	0.4	-0.7	-0.9	-0.3	0.5
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.2	0.9	0.9	0.4	0.1	0.2	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	-0.4	0.0	-0.3	0.9	0.5	0.5	1.1
Ever smoked	0.3	0.6	1.6	0.6	-1.2	-1.1	-0.5	-0.6	0.2	-0.5
Leg fat percentage (left)	0.3	1.0	2.2	-1.5	-0.9	-1.3	-0.5	-0.6	-0.9	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.1	-0.9	-0.3	-0.4	0.9	0.9	-0.2
HbA1C	0.2	0.3	0.5	0.7	-0.4	-0.7	-0.0	0.5	0.6	0.2
Systolic Blood Pressure	0.2	1.0	3.0	1.0	-0.5	-1.7	0.9	0.1	-1.2	-0.1
Allergy or Eczema	0.2	0.5	1.0	0.5	1.0	1.0	-0.3	-0.8	-0.6	0.0
Tanning	0.2	2.3	4.5	-1.3	-0.9	-0.7	-1.7	-1.5	-2.1	-1.8
Systolic blood pressure, automated reading	0.2	0.7	3.2	-0.0	-0.9	-1.8	0.8	0.4	-0.3	-0.2
Pack years adult smoking proportion	0.2	0.3	0.6	0.8	-0.6	-0.7	-0.3	-0.1	0.5	0.3
Townsend deprivation index at recruitment	0.2	0.2	0.6	0.8	0.5	0.8	0.5	0.1	0.0	-0.0
Average weekly fortified wine intake	0.2	0.2	1.0	-0.2	0.1	0.2	0.4	-0.2	-1.0	-0.6
Relative age voice broke	0.2	0.3	0.9	0.1	0.6	0.7	-0.6	-0.2	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.4	0.5	0.8	0.6	0.4	0.0	-1.2	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	1.0	0.9	0.8	-0.5	0.2	-0.4	-0.1
Supplements: Glucosamine	0.2	0.3	1.1	0.3	0.8	1.0	0.0	0.2	0.4	0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.5	-0.0	-0.1	0.8	0.5	0.7	0.4
Financial difficulties in last 2 years	0.2	0.3	1.0	0.2	-0.5	-0.8	1.0	-0.1	-0.3	-0.3
Illnesses of siblings	0.2	0.3	1.6	-1.3	0.0	0.0	-0.2	-0.1	-0.3	0.3
Trunk fat-free mass	0.2	1.2	3.9	-2.0	1.3	1.5	-0.3	-0.0	0.1	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.7	-0.7	-0.8	-0.3	-0.7	-0.5	-0.3
Trunk predicted mass	0.2	1.1	3.7	-1.9	1.2	1.3	-0.2	0.0	0.2	0.8
Hair/balding pattern: Pattern 4	0.2	0.6	1.4	1.1	-0.6	-1.2	0.4	-0.2	-0.8	-0.4
Gout (self-reported)	0.2	0.3	1.5	-0.3	0.1	0.4	-0.0	0.5	1.2	0.7
Birth weight	0.2	0.3	1.2	0.1	0.5	0.4	1.1	-0.4	0.4	0.6
Arm fat-free mass (right)	0.2	1.0	4.4	-2.1	0.8	0.9	-0.6	-0.2	0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.2	-0.7	-0.6	-0.4	0.1	0.5	0.5
Medication: Blood pressure	0.2	0.3	1.5	-0.1	-0.1	-0.4	-0.4	-0.1	-1.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.1	0.3	-0.2	-0.3	0.4	0.2	1.1	0.5
Leg fat mass (right)	0.2	0.6	2.5	-1.6	-0.6	-0.9	-0.5	-0.3	-0.4	-0.2
Arm predicted mass (right)	0.2	1.0	5.0	-2.2	0.7	0.7	-0.5	-0.3	0.0	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.6	0.3	0.6	0.2	0.7	0.1	-0.7
Illnesses of father: Heart disease	0.2	0.2	1.0	-0.3	0.2	0.1	-0.4	-0.3	-1.0	-0.3
Whole body fat-free mass	0.2	1.0	3.6	-1.9	1.1	1.3	-0.5	-0.3	0.1	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.4	-0.1	-0.4	-0.6	-0.7	-0.6	0.0
Whole body water mass	0.2	1.0	3.2	-1.8	1.1	1.3	-0.5	-0.3	0.1	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.2	0.2	0.6	0.5	0.7	0.7	-0.3
Financial situation satisfaction	0.2	0.3	1.0	-0.3	-0.4	-0.5	-0.2	-0.4	-1.0	-0.5
Medication: Lisinopril	0.2	0.3	0.9	0.3	-0.5	-0.5	-0.0	-0.2	-0.9	-0.8
Alcohol drinker status: Never	0.2	0.3	0.6	-0.6	0.5	0.8	-0.8	0.4	-0.2	0.1
Arm fat-free mass (left)	0.2	0.9	3.9	-2.0	0.9	0.8	-0.3	-0.3	0.1	0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.8	0.1	0.4	0.3	0.3	0.9	0.7	0.5
Alcohol drinker status: Previous	0.2	0.3	0.5	0.5	0.4	0.1	-0.2	-0.7	-0.7	-0.5
Pack years of smoking	0.2	0.3	1.0	0.5	-0.8	-1.0	-0.1	-0.1	0.2	0.1
Arm predicted mass (left)	0.2	0.8	3.3	-1.8	1.0	1.0	-0.1	-0.1	0.2	0.8
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.4	0.4	0.6	0.1	0.2	-0.4	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.7	-0.8	-0.1	-0.3	-0.2	-0.1	0.2	0.2
Heel T-Score	0.1	0.6	2.2	-0.3	-0.3	-0.5	0.6	-0.5	-1.5	-0.8
BMI	0.1	0.4	1.4	-1.2	-0.1	-0.2	0.7	0.3	-0.5	-0.9
Height	0.1	1.1	2.1	-1.3	-1.4	-1.1	-1.1	-0.4	1.1	0.6
Hair Pigment	0.1	2.5	7.3	0.7	-2.7	-2.5	0.1	-0.2	-0.4	-1.8
Relative age of first facial hair	0.1	0.1	0.5	0.4	0.1	0.4	0.2	-0.7	-0.0	-0.0
Leg fat-free mass (left)	0.1	0.6	2.2	-1.5	0.7	0.9	-0.6	-0.3	0.3	0.5
Trunk fat percentage	0.1	0.3	1.2	-0.5	-0.8	-1.1	-0.3	0.2	0.2	-0.0
Body mass index (BMI)	0.1	0.6	2.6	-1.6	-0.4	-0.7	-0.3	-0.2	-0.6	-0.6
Leg predicted mass (left)	0.1	0.6	2.2	-1.5	0.7	0.9	-0.6	-0.3	0.3	0.5
Trunk fat mass	0.1	0.2	1.0	-1.0	-0.3	-0.6	-0.1	0.4	0.2	0.2
Had menopause	0.1	0.1	0.4	-0.5	0.3	0.7	-0.2	-0.1	0.1	-0.1
Mouth/teeth dental problems	0.1	0.2	0.6	0.1	-0.5	-0.5	0.8	0.1	-0.0	-0.4
Allergy	0.1	0.2	0.4	-0.7	0.3	0.2	0.6	-0.5	-0.4	0.3
Fluid intelligence score	0.1	0.3	1.0	0.2	-0.4	-0.1	-0.4	1.0	0.5	-0.6
Weight	0.1	0.5	3.2	-1.8	-0.1	-0.2	-0.5	-0.1	-0.1	-0.1
Arm fat percentage (right)	0.1	0.2	0.8	-0.5	-0.7	-0.9	-0.2	0.1	0.2	-0.3
Hip circumference	0.1	0.5	1.1	-0.2	1.0	1.0	-0.8	0.1	0.4	0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.9	0.0	0.3	0.9	-0.5	0.2	0.0	-0.9
Standing height	0.1	0.8	2.1	-0.5	0.8	0.9	-0.1	0.4	1.2	1.4
Blood clot in the leg (DVT)	0.1	0.1	0.6	0.1	-0.5	-0.2	-0.1	0.8	0.1	-0.2
Body fat percentage	0.1	0.5	1.6	-0.8	-0.9	-1.2	-0.5	-0.0	-0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.2	0.3	0.1	-0.5	-0.3	0.4	0.5
Whole body fat mass	0.1	0.3	1.2	-1.1	-0.4	-0.8	-0.2	0.3	0.1	0.2
Alcohol intake frequency.	0.1	0.2	0.6	0.5	0.8	0.6	0.3	0.4	-0.4	-0.1
Leg fat-free mass (right)	0.1	0.7	2.1	-1.4	0.8	1.1	-0.6	-0.5	0.2	0.3
Arm fat percentage (left)	0.1	0.4	1.2	-0.5	-0.9	-1.1	-0.5	-0.2	-0.0	-0.5
Leg predicted mass (right)	0.1	0.6	1.9	-1.4	0.8	1.1	-0.5	-0.4	0.3	0.4
Arm fat mass (left)	0.1	0.3	1.0	-1.0	-0.6	-0.8	-0.3	-0.2	-0.1	-0.4
Basal metabolic rate	0.1	0.7	3.2	-1.8	0.8	0.9	-0.4	-0.2	0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.8	0.3	-0.0	0.3	0.2	0.9	0.1	-0.2
Leg fat mass (left)	0.1	0.5	2.4	-1.6	-0.4	-0.7	-0.3	-0.2	-0.3	-0.2
Hand grip strength (right)	0.0	0.1	0.4	0.3	-0.4	-0.3	-0.6	-0.3	-0.1	-0.3
Arm fat mass (right)	0.0	0.2	0.8	-0.9	-0.3	-0.5	0.0	0.3	0.3	0.1
Age at first live birth	0.0	0.1	0.2	0.4	-0.2	0.1	-0.3	0.3	0.4	0.2

Hub : Genes

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Trait associations