TWAS hub - CHI3L2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.4060	0.1210	1.8e-03	0.265	NA	0.154	NA	0.256	1.7e-07	NA	9.4e-05	NA	2.9e-07
2	GTEx	Whole Blood	0.3150	0.0630	2.2e-08	0.229	NA	0.215	NA	0.214	6.1e-21	NA	1.3e-19	NA	1.7e-19
3	METSIM	Adipose	0.0372	0.0165	8.3e-03	0.006	0.013	0.002	0.013	0.005	3.2e-02	3.8e-03	1.5e-01	3.4e-03	4.5e-02
4	NTR	Blood	0.0536	0.0150	5.0e-07	0.042	0.024	0.053	0.047	0.050	2.0e-13	1.8e-08	8.9e-17	7.9e-15	6.9e-16
5	YFS	Blood	0.5650	0.0338	0.0e+00	0.360	0.436	0.478	0.469	0.486	1.4e-124	3.2e-159	1.4e-180	7.5e-176	1.8e-184
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0515	0.0231	6.7e-04	0.012	0.037	0.033	NA	0.026	1.6e-02	4.5e-05	1.1e-04	NA	5.6e-04
7	TCGA	Thyroid Carcinoma	0.1110	0.0370	1.8e-06	0.035	0.048	0.093	NA	0.081	2.1e-04	1.7e-05	2.2e-09	NA	2.4e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Tinnitus: Yes, but not now, but have in the past	3.9	4.2	7.7	-2.1	-2.8	-0.3	-2.0	-2.6	-2.0	1.6
Supplements: Fish oil (including cod liver oil)	3.7	4.9	8.3	-1.8	-2.5	2.9	-2.1	-2.3	-2.0	1.6
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	6.0	-1.6	-2.1	-0.7	-1.5	-2.5	-2.0	1.2
Severe depression (siblings)	2.4	2.7	6.6	-2.0	-2.0	0.5	-1.4	-2.6	-1.1	1.0
Noisy workplace	2.4	3.0	8.1	-2.8	-1.9	0.2	-0.4	-2.4	-1.3	1.4
Eye problems/disorders: Cataract	2.4	2.8	6.2	-1.2	-2.0	1.1	-2.0	-2.5	-1.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	5.0	1.7	1.2	-1.1	1.5	2.2	2.1	-0.3
Mouth/teeth dental problems: Dentures	2.2	3.6	7.1	-0.7	2.4	0.8	2.7	2.3	0.5	-2.5
Frequency of depressed mood in last 2 weeks	2.1	3.0	10.4	-0.1	-2.3	0.3	-1.4	-1.8	-0.3	3.2
Mineral and other dietary supplements	2.1	2.8	7.3	1.5	1.8	-2.7	1.4	1.4	1.2	-1.0
Coronary Artery Disease (CAD)	1.9	2.2	7.4	0.9	1.8	0.6	1.0	1.6	2.7	-0.4
Pulse rate, automated reading	1.9	6.2	10.0	-0.4	2.7	3.2	3.0	2.5	1.9	-2.6
Knee pain experienced in last month	1.9	2.9	6.8	-2.0	-2.2	-0.4	-1.6	-2.6	-1.3	0.9
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	7.3	2.7	1.6	1.0	0.5	1.5	0.7	-1.1
Time employed in main current job	1.8	2.1	5.3	-1.6	-1.7	0.3	-0.4	-1.7	-2.3	0.9
Glaucoma (self-reported)	1.8	2.2	4.8	2.2	1.9	0.1	1.2	1.5	1.1	-1.3
Had major operations	1.8	2.2	5.3	-2.3	-1.5	1.3	0.1	-1.2	-1.1	1.8
Family relationship satisfaction	1.8	2.2	5.5	-0.8	-1.0	2.4	-0.5	-1.5	-1.6	1.7
Supplements: Vitamin C	1.8	2.2	7.5	-1.2	-1.1	2.7	0.8	-1.0	-1.8	-0.3
Fractured/broken bones in last 5 years	1.8	2.3	4.2	2.1	1.7	-0.5	1.5	1.8	1.8	-0.4
Ovarian Cancer	1.7	2.3	7.7	-2.8	-1.1	2.1	1.1	-0.8	-0.9	-0.1
Pulse rate	1.7	2.8	5.6	-0.9	2.2	1.7	2.4	1.6	1.3	-1.2
Alzheimer’s Disease (in father)	1.6	1.7	4.8	-1.6	-0.6	2.2	-0.2	-1.0	0.7	1.7
Number of live births	1.6	2.2	4.3	1.1	2.1	1.6	1.4	1.8	1.3	0.7
Exposure to tobacco smoke at home	1.6	1.8	4.5	-0.3	-0.9	-0.3	-2.1	-1.7	-2.1	-0.3
Migraine (self-reported)	1.6	2.0	6.2	-2.5	-0.0	1.5	1.6	-0.6	-1.6	0.5
Commuting to job workplace: Walk	1.6	1.7	3.7	0.9	1.6	0.9	1.0	1.9	0.7	-1.6
Average weekly beer plus cider intake	1.6	2.3	9.6	1.2	-1.2	-0.3	-3.1	-1.6	-0.2	0.8
Mean Putamen Volume	1.5	1.8	3.8	1.4	1.3	1.9	0.5	1.7	0.5	-1.2
Ever had hysterectomy (womb removed)	1.5	1.7	5.7	-2.4	-1.5	-0.3	-0.2	-1.7	-0.2	1.0
Medication: Blood pressure	1.5	2.7	8.0	-2.8	-2.0	0.2	-0.2	-1.6	-2.1	0.3
HbA1C	1.4	1.6	3.9	2.0	1.3	-1.5	0.3	1.0	0.5	-1.3
Birth weight of first child	1.4	2.6	10.6	1.1	-1.3	-1.6	-3.3	-0.9	-0.7	0.7
Lung FEV1/FVC ratio	1.3	6.7	33.5	-1.7	-1.1	5.8	0.3	-1.9	-2.0	1.0
Taking other prescription medications	1.3	2.0	5.7	-2.1	-0.2	2.4	1.8	-0.4	-0.4	0.2
Diabetes (self-reported)	1.3	2.0	4.8	-2.1	-0.4	2.2	0.5	-0.8	-1.9	0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	6.1	2.5	0.2	-1.5	-1.5	0.6	-1.5	-1.3
Smoking status: Previous	1.3	2.0	5.7	0.2	1.4	-0.5	1.7	1.3	2.4	-1.2
Ever had bowel cancer screening	1.3	1.5	3.0	-1.6	0.0	1.4	1.4	-0.3	1.0	1.7
Mother’s age at death	1.3	1.6	6.7	-1.5	-1.1	0.2	-0.4	-0.7	-2.6	0.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.8	-1.9	-1.5	-0.3	-1.5	-1.8	-0.6	0.4
Reaction Time	1.2	2.2	4.0	1.9	1.3	2.0	1.6	1.2	1.5	-0.6
Number of treatments/medications taken	1.2	2.2	6.0	-2.5	-1.2	1.2	1.3	-1.0	-1.7	0.9
Medication: Metformin	1.2	1.6	4.7	-2.2	-1.0	1.1	1.1	-0.4	-1.7	0.5
Heart attack	1.2	1.5	3.8	-2.0	-1.4	-0.3	-1.3	-1.6	-0.6	0.2
Pain all over the body in last month	1.2	1.3	5.9	-0.7	-0.7	2.4	-0.1	-0.6	0.7	1.1
Medication: Lansoprazole	1.2	1.3	3.6	-0.2	1.4	1.9	1.1	0.8	1.0	-0.9
Mean time to correctly identify matches	1.2	2.3	5.8	1.4	1.1	2.4	1.5	1.1	1.8	-0.9
Medication: Aspirin	1.2	1.6	8.0	-2.8	-0.5	0.2	0.4	-1.2	-1.0	0.6
Illnesses of father: High blood pressure	1.2	1.5	3.0	-1.5	-1.6	0.4	-1.1	-1.7	-0.3	1.2
Number of operations (self-reported)	1.2	1.7	3.1	-1.7	-1.5	0.3	-0.4	-1.7	-0.8	1.8
Rheumatoid Arthritis	1.1	1.5	3.6	1.4	-1.2	-1.3	-1.9	-0.9	-0.7	-0.8
Ever used hormone-replacement therapy (HRT)	1.1	1.5	2.7	-0.8	-0.8	0.1	-1.6	-1.6	-1.3	1.5
Supplements: Zinc	1.1	1.2	2.0	1.4	1.0	1.4	0.8	1.4	0.9	-0.1
Multivitamins +/- minerals	1.1	1.4	3.5	-0.2	-1.0	1.2	-1.3	-0.9	-1.9	1.3
Number of incorrect matches in round	1.1	1.9	4.3	-0.5	2.1	1.1	2.0	1.7	0.7	0.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	4.8	-1.4	-0.0	1.6	2.2	-0.2	-0.3	0.1
Medication: Simvastatin	1.1	1.6	5.9	-0.4	0.4	0.8	1.0	0.7	-1.8	-2.4
Medication: Cholesterol lowering	1.1	1.7	2.7	-1.6	-0.8	1.6	0.8	0.1	-1.6	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	5.5	2.0	-0.3	0.2	0.3	0.5	2.4	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.6	2.4	1.1	-0.6	-0.8	0.3	1.7	1.2
Medication: Amlodipine	1.1	1.5	2.9	-1.3	-1.6	0.7	-0.3	-1.7	-1.6	0.8
Worry too long after embarrassment	1.1	1.9	5.0	0.1	-2.2	0.9	-2.0	-1.6	-1.0	0.6
Medication: Seretide 50 evohaler	1.1	1.2	5.8	1.0	-0.7	-0.2	-0.8	-0.4	0.6	2.4
Chest pain or discomfort	1.1	1.6	3.0	-1.7	-1.7	1.3	-0.3	-1.1	-0.2	1.6
Breast cancer (self-reported)	1.1	1.3	3.9	-2.0	0.4	1.1	1.5	-0.3	-0.6	1.1
Ever taken oral contraceptive pill	1.1	1.2	5.2	0.7	-0.4	-2.3	-0.2	0.3	0.5	1.5
Eye problems/disorders: Glaucoma	1.1	1.3	3.1	1.3	1.4	-0.1	1.2	1.0	0.0	-1.8
Fasting Glucose	1.0	1.2	3.7	1.3	-0.6	0.4	-1.9	-1.0	-0.5	-1.0
Hand grip strength (left)	1.0	2.6	6.5	0.3	-1.9	-1.5	-2.5	-1.9	-1.4	0.7
Medication for hormone replacement therapy	1.0	1.1	2.5	-0.7	-0.9	-0.5	-0.7	-1.4	-1.6	1.1
Vitamin and mineral supplements	1.0	1.4	4.7	0.7	0.5	-2.2	-0.4	0.5	1.9	-0.3
Diabetes (mother)	1.0	1.3	2.4	-1.5	-1.1	1.5	0.5	-0.7	-1.2	0.9
Stomach or abdominal pain in last month	1.0	1.2	2.8	-1.7	-0.8	-1.5	-0.1	-1.0	-1.4	0.3
Loneliness, isolation	1.0	1.4	2.8	-1.1	-1.6	0.4	-0.8	-1.7	-0.7	1.4
Diabetes diagnosed by doctor	1.0	1.6	5.2	-1.7	-0.1	2.3	0.7	-0.4	-1.5	0.7
Medication: Lisinopril	1.0	1.2	4.6	-2.1	-0.2	1.3	-0.6	-0.6	-0.5	-1.1
Schizophrenia (2018)	0.9	1.9	4.1	-1.5	1.2	1.7	2.0	0.2	1.0	-1.3
Ulcerative Colitis (UC)	0.9	1.7	5.9	1.2	1.5	0.5	0.9	1.0	2.4	-0.6
Major Depression (MDD)	0.9	1.1	2.5	0.2	1.2	-0.9	1.6	0.7	0.2	-1.5
Ulcerative Colitis	0.9	1.3	3.6	1.9	1.1	-0.2	-0.6	0.6	1.8	-0.7
Mouth/teeth dental problems	0.9	1.3	4.7	1.5	-0.5	-0.8	-2.2	-0.8	0.4	0.7
Age at last live birth	0.9	1.2	2.4	1.4	1.1	0.7	1.5	1.4	-0.5	-0.6
Long-standing illness, disability or infirmity	0.9	1.3	3.1	-1.2	-0.4	1.7	1.2	0.1	0.2	1.8
Ever depressed for a whole week	0.9	1.2	3.7	-1.1	-0.8	1.9	1.4	-0.6	0.1	0.2
Alzheimer’s Disease (including proxy)	0.8	1.1	3.6	-0.2	0.9	1.9	0.7	0.4	1.4	0.7
Crohns Disease (2017)	0.8	1.7	5.1	-1.1	-0.5	1.6	0.9	-1.3	-0.1	2.3
Prostate Cancer	0.8	1.1	2.8	0.5	1.3	-1.1	0.7	0.8	-0.6	-1.7
LDL Cholesterol	0.8	1.2	2.2	-0.7	-1.5	0.2	-1.3	-1.3	-1.4	0.5
Schizophrenia (2014)	0.8	1.8	2.9	-0.5	1.7	1.7	1.7	0.8	1.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.6	-1.0	0.5	1.1	1.6	1.1	1.0	0.5
Financial difficulties in last 2 years	0.8	1.1	2.5	1.6	0.6	-0.5	0.9	1.2	1.5	-0.4
Medication: Ramipril	0.8	1.0	2.2	-1.2	-0.9	-1.2	-0.1	-0.9	-1.5	0.1
Alcohol intake versus 10 years previously	0.8	1.3	6.5	-0.5	-0.4	-0.2	0.0	-1.2	-2.5	0.6
Father’s age at death	0.8	1.1	2.4	0.9	0.3	-1.4	1.1	0.3	1.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.3	-1.4	-0.7	0.4	1.0	-0.2	0.6	2.3
Hair/balding pattern: Pattern 3	0.8	1.2	3.1	1.4	1.2	-0.4	0.2	1.8	1.1	-0.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.9	-0.8	-1.4	-0.0	-0.4	-1.3	-0.9	1.3
Medication: Paracetamol	0.8	1.4	4.4	-0.6	0.3	1.1	1.2	0.0	1.5	2.1
Number of children fathered	0.8	1.0	2.0	-1.4	-1.1	0.1	-0.8	-1.0	-1.4	0.1
Eye problems/disorders: None of the above	0.8	0.9	2.2	1.0	0.5	-1.3	0.2	1.2	1.5	-0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.4	-0.5	1.2	1.2	1.1	0.7	1.0	-1.0
Medication: Aspirin	0.8	1.1	5.6	-2.4	-0.4	0.3	0.3	-1.0	-0.8	0.5
Risk taking	0.8	1.2	4.7	0.3	0.8	-2.2	0.8	0.7	1.0	0.9
Bipolar Disorder (2011)	0.7	0.7	2.7	1.1	-0.0	-0.1	-0.2	0.1	0.8	1.7
Crohns Disease (2012)	0.7	1.1	2.6	-0.7	-0.7	1.6	-0.0	-1.2	-0.2	1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.6	-0.4	-0.9	0.9	-0.5	-0.7	-1.6	0.3
Angina	0.7	1.0	3.6	-1.7	-0.3	-0.1	0.0	-0.4	-1.9	0.0
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.3	1.8	1.0	-0.3	0.2	1.7	1.4	1.3
High blood pressure (mother)	0.7	1.0	2.7	-1.6	-0.4	1.1	1.1	0.0	-0.6	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.6	0.0	-1.9	0.4	-0.3	-1.1	-0.8	1.5
Allergy	0.7	1.6	5.0	-2.2	-0.8	0.5	0.3	-1.6	-1.2	-1.1
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.8	1.9	0.5	1.0	0.5	1.0	0.8	-0.1
Worrier / anxious feelings	0.7	1.3	3.1	-0.3	-1.4	-1.3	-1.1	-0.9	0.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-1.0	-0.7	1.1	-0.9	-1.2	0.9	-0.5
Lung cancer (father)	0.7	0.9	1.7	0.8	-0.8	-0.2	-1.3	-0.9	1.3	0.9
Pulse wave Arterial Stiffness index	0.7	0.8	3.3	-1.8	0.9	0.1	0.9	0.4	-0.5	-0.6
Exposure to tobacco smoke outside home	0.7	0.9	2.8	1.0	-0.3	-1.7	-0.8	-0.4	-1.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	-1.1	-1.0	-0.8	-0.6	-0.7	-1.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	0.3	-0.9	-0.6	-1.0	-1.1	-0.5	1.4
Angina (self-reported)	0.7	0.9	3.5	-1.6	0.1	0.1	0.3	-0.1	-1.9	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.5	-2.1	-0.3	0.2	1.7	0.2	-0.3	-0.2
Miserableness	0.7	1.1	1.7	-0.2	-1.3	-1.1	-1.3	-1.2	0.8	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	-1.5	-0.1	0.4	0.2	-0.8	-1.1	-1.2
High cholesterol (Self-reported)	0.7	1.3	5.7	-0.6	0.3	-0.1	1.1	0.9	-0.7	-2.4
Alcohol drinker status: Never	0.7	0.8	3.0	-1.1	0.1	0.1	-0.3	-0.6	-1.0	-1.7
Ever smoked	0.7	1.2	4.7	0.6	0.5	-0.9	0.8	1.3	2.2	0.0
Age started oral contraceptive pill	0.7	0.8	2.9	-0.4	-0.5	-1.7	-0.7	-0.6	-1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	-0.2	0.7	1.2	1.5	1.1	0.8	-0.5
Alcohol drinker status: Previous	0.7	0.8	3.0	0.9	-0.8	0.7	-0.1	-0.2	0.7	1.7
Depression (Nagel 2018)	0.6	0.9	3.3	0.6	-1.3	-0.6	-0.6	-0.6	0.2	1.8
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	-0.5	1.1	1.1	0.9	0.4	1.3	-0.8
Blood Platelet Count	0.6	7.2	30.6	1.8	-0.6	-5.5	-3.2	0.3	2.3	0.5
Maternal smoking around birth	0.6	0.9	2.7	0.8	0.6	-1.1	0.1	1.0	0.1	-1.6
Supplements: Glucosamine	0.6	0.7	1.5	-0.2	-1.2	1.0	-1.0	-0.9	-0.8	0.3
Past tobacco smoking	0.6	1.1	3.9	-0.4	-0.5	1.1	-1.0	-1.0	-2.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.6	0.8	-0.3	0.6	0.0	-0.1	1.9	0.8
Age at first live birth	0.6	1.1	3.1	0.7	1.2	0.7	1.2	1.1	-0.1	-1.8
Pulse wave peak to peak time	0.6	0.7	2.9	1.7	-0.9	-0.4	-0.9	-0.4	0.3	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	-0.6	-1.1	-0.3	-0.4	-1.1	-0.9	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.4	0.4	0.9	1.2	0.4	1.2	-1.1
Illnesses of father: Heart disease	0.6	0.9	4.2	-0.1	0.4	2.0	0.9	0.2	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	6.4	-0.1	0.2	2.5	1.0	-1.1	0.3	0.3
Number of self-reported non-cancer illnesses	0.6	1.0	3.5	-0.7	0.5	0.9	1.9	1.1	-0.7	-0.4
Average weekly champagne plus white wine intake	0.6	0.8	1.7	0.3	1.2	-0.2	0.8	0.9	1.3	-1.0
Medication: Paracetamol	0.6	0.9	2.1	-0.4	0.1	1.4	1.0	0.1	1.1	1.5
Commuting to job workplace: Cycle	0.6	0.8	1.6	-0.1	1.1	0.7	0.5	1.3	0.7	-1.1
Heart disease (siblings)	0.6	0.8	3.8	-0.5	0.2	1.9	0.2	0.4	-1.0	0.0
Bipolar Disorder (2018)	0.5	0.8	3.2	1.8	0.3	-0.6	0.1	0.8	0.7	0.7
Blood Eosinophil Count	0.5	4.2	19.6	0.4	-1.9	-4.4	-1.8	-1.2	-0.8	-0.5
Respiratory disease	0.5	1.1	4.9	2.2	0.3	0.5	0.2	1.2	1.0	0.6
Average weekly spirits intake	0.5	0.6	1.1	-0.6	0.7	1.0	0.9	0.6	0.3	-1.0
Hearing difficulty/problems: Yes	0.5	0.7	1.9	-0.9	0.5	0.6	1.4	0.6	-0.1	-1.1
Medication: Co-codamol	0.5	0.6	1.5	-0.9	0.2	1.2	0.5	-0.0	0.8	-0.8
Hand grip strength (right)	0.5	1.3	3.6	1.2	-0.4	-1.9	-1.5	-0.4	-0.7	-0.9
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.0	1.2	0.3	0.4	1.2	0.4	-0.5
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	1.5	0.2	-0.8	-0.1	1.0	0.3	-0.2
Alcohol usually taken with meals	0.5	0.7	1.9	0.8	-0.5	-1.4	-1.3	-0.5	-0.5	-0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-1.1	0.5	0.3	1.3	-0.6	-0.8	0.1
Asthma	0.5	1.0	2.8	1.7	0.9	1.0	0.6	1.3	0.8	0.2
Breastfed as a baby	0.5	0.6	1.2	1.1	0.1	-1.0	-0.8	0.5	1.0	0.4
Loud music exposure frequency	0.5	0.6	2.0	0.6	0.2	-0.4	1.1	0.6	-0.1	1.4
Gout (self-reported)	0.5	0.7	1.9	-1.4	-0.4	0.6	-0.4	-1.2	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	1.4	0.1	-0.0	-0.0	0.5	0.6	1.3
Medication: Ibuprofen	0.5	0.6	1.4	-0.4	-0.7	0.8	-0.7	-0.7	1.2	-0.6
Overall health rating	0.5	1.0	3.2	-1.4	-0.7	1.8	0.4	-0.2	1.0	0.5
Hypertension (Self-reported)	0.5	1.4	4.3	-2.1	-0.6	0.5	0.2	-0.6	-1.1	-1.8
Mood swings	0.5	0.8	1.9	1.3	-0.1	-1.0	-0.4	0.3	1.4	0.9
Friendships satisfaction	0.5	0.6	1.3	1.1	0.4	1.1	-0.2	0.3	-1.1	0.6
Qualifications: nursing, teaching	0.5	0.8	2.6	0.9	-0.4	-1.6	-0.1	0.1	-0.6	1.2
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.7	-1.2	0.1	-1.0	-1.2	-0.3	0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.3	-1.5	-0.6	-0.1	1.0	-0.1	-0.9	0.1
Medication: Atorvastatin	0.5	0.6	1.7	-1.1	0.1	0.5	1.3	0.8	0.2	0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-0.0	1.2	0.9	1.6	0.7	1.2	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	0.1	-1.1	-0.7	-1.0	-1.1	0.5	1.4
Irritable Bowel Disease (IBD)	0.4	0.9	2.0	0.2	0.7	1.1	0.9	-0.2	1.4	1.3
Neuroticism (2016)	0.4	0.5	2.0	-0.6	0.5	0.7	1.4	0.9	0.1	-0.3
Primary Biliary Cirrhosis	0.4	0.6	2.0	-1.1	-0.4	-1.4	0.5	0.0	-0.8	-0.5
Triglycerides	0.4	0.7	2.3	-1.5	-1.1	-0.4	-0.6	-0.7	-0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.7	0.5	-0.7	-1.3	-0.6	-0.2	0.0	0.7
Allergy or Eczema	0.4	1.0	2.3	1.3	0.7	0.2	0.3	1.1	1.5	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	-1.4	-0.0	1.5	0.8	-0.1	-0.5	0.6
Diabetes (father)	0.4	0.5	1.4	0.0	0.7	0.4	0.3	0.1	-1.2	-1.1
Age when periods started (menarche)	0.4	0.9	2.4	-1.5	-0.5	0.6	-0.8	-1.3	-1.1	-0.3
Serious illness, injury or assault to yourself	0.4	0.4	1.1	0.0	-1.1	-0.6	-0.6	-0.8	-0.7	0.0
High blood pressure	0.4	1.0	2.7	-1.6	-0.9	0.2	0.1	-0.6	-1.2	-1.3
Fluid intelligence score	0.4	0.8	1.8	-0.8	1.3	-0.3	1.0	1.3	-0.3	-0.1
Falls in the last year	0.4	0.5	1.2	-0.7	-1.1	1.0	0.4	-0.3	-0.4	0.6
Depression (self-reported)	0.4	0.4	1.4	0.1	0.7	-0.1	1.2	0.6	-0.4	-0.8
Length of working week for main job	0.4	0.5	2.2	0.5	0.1	-0.2	-0.1	0.2	0.8	1.5
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.9	-0.9	-0.4	0.4	0.8	-0.3	-0.5	1.0
Blood clot in the leg (DVT)	0.4	0.5	1.2	0.2	-0.9	-1.0	-0.8	-0.1	-1.1	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	-0.9	0.1	0.9	-0.0	-1.2	0.1	-0.1
Leg fat percentage (right)	0.4	1.5	5.2	-2.3	-1.4	1.1	0.2	-1.2	-0.7	0.1
Shortness of breath walking on level ground	0.4	0.4	1.2	-1.1	-1.1	-0.3	0.2	-0.6	-0.3	0.3
Medication: Omeprazole	0.4	0.4	1.3	0.6	0.2	1.1	1.0	0.6	0.2	0.2
Leg fat mass (right)	0.4	1.5	5.4	-2.3	-1.2	0.4	0.2	-1.4	-1.1	-0.3
Alcohol intake frequency.	0.4	1.0	2.3	-0.2	-1.1	-0.0	-1.1	-1.5	-1.5	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.4	-1.2	1.1	-0.3	-0.3	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.2	-0.9	0.7	0.2	-0.8	-0.8	0.5
Asthma (self-reported)	0.4	0.8	2.7	1.6	0.8	0.7	0.6	1.2	0.5	0.2
Medication: Gliclazide	0.4	0.4	1.8	-1.4	-0.0	0.6	0.4	-0.8	-0.3	-0.0
Guilty feelings	0.4	0.6	2.1	-1.4	-0.0	0.2	1.2	-0.3	0.6	-0.3
Financial situation satisfaction	0.4	0.5	1.4	-0.4	0.5	-0.7	1.2	0.8	0.5	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	-1.2	-0.2	0.5	1.1	0.3	-0.6	0.2
Unable to work because of sickness or disability	0.4	0.5	2.1	-0.3	-1.0	0.4	-0.1	-0.4	0.3	1.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.0	1.7	1.0	-0.0	-0.0	0.6	1.5	0.9
Cholesterol lowering medication	0.4	0.6	1.3	-0.5	1.2	-0.6	1.0	0.9	-0.0	-0.1
Supplements: Calcium	0.4	0.4	1.6	-0.0	0.2	1.3	0.9	0.5	0.1	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	3.0	0.4	0.2	-1.7	0.1	0.3	0.2	-0.3
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.3	1.0	-0.3	0.5	0.7	0.6	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.5	-0.8	-0.1	-1.6	-1.0	0.0	0.2	1.2
HDL Cholesterol	0.3	0.5	1.6	-0.4	-0.8	0.3	-0.7	-0.8	-0.2	1.2
Lupus	0.3	0.4	1.0	-1.0	0.2	-0.4	0.8	0.3	0.9	-0.6
Systolic Blood Pressure	0.3	1.4	4.8	1.0	0.7	1.6	-0.1	1.2	0.2	-2.2
Cardiovascular Disease	0.3	1.1	4.6	-1.3	-0.1	-0.4	0.5	0.6	-0.8	-2.1
Hypothyroidism (self reported)	0.3	0.8	3.9	-0.7	-0.2	0.1	0.0	-0.4	-2.0	-0.8
Relative age of first facial hair	0.3	0.6	2.2	1.5	0.4	-0.6	-0.9	0.3	-0.5	-0.5
Trunk fat percentage	0.3	1.2	4.4	-2.1	-1.0	0.9	0.5	-1.0	-0.5	-0.7
Average weekly fortified wine intake	0.3	0.4	0.9	0.3	-0.5	1.0	0.7	0.7	-0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	0.8	0.2	0.5	0.4	0.4	0.3	1.1
Medication: Atenolol	0.3	0.4	0.8	-0.7	0.3	-0.9	0.1	-0.3	-0.8	-0.9
Medication: Levothyroxine sodium	0.3	0.5	2.6	-0.2	0.1	0.5	0.5	0.1	-1.6	-0.2
Trunk fat mass	0.3	1.2	4.1	-2.0	-1.0	0.5	0.4	-1.1	-0.8	-0.8
Waist circumference	0.3	1.0	3.6	-1.1	0.5	0.0	1.4	0.2	0.3	-1.9
Illnesses of siblings	0.3	0.5	1.7	-0.5	-0.2	-1.3	-0.4	-0.5	-0.8	0.4
Happiness	0.3	0.4	0.8	0.7	-0.6	-0.5	-0.5	-0.4	0.3	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.3	0.0	1.1	0.0	1.5	1.2	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	0.1	0.2	-0.8	-0.6	-0.6	-0.6	-0.8
Illnesses of mother	0.3	0.4	1.9	0.7	0.3	-0.3	-1.4	-0.3	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	-0.5	0.8	-0.3	1.3	0.6	0.3	-0.7
Body fat percentage	0.3	1.0	3.8	-1.9	-1.1	0.8	0.5	-1.0	-0.5	-0.4
Health satisfaction	0.3	0.4	1.3	-1.1	0.2	0.8	0.2	-0.3	0.8	0.2
Qualifications: College or University degree	0.3	1.0	3.9	0.2	0.4	0.4	0.9	1.0	-1.1	2.0
Emphysema/chronic bronchitis	0.3	0.4	1.0	-0.2	-0.8	-0.0	-0.6	-0.4	0.4	1.0
Heart disease (mother)	0.3	0.3	1.6	0.5	-0.2	1.3	-0.2	0.1	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.0	0.0	0.6	0.3	-0.1	0.1	1.4	0.5
Whole body fat mass	0.3	1.1	4.5	-2.1	-0.9	0.4	0.5	-1.0	-0.8	-0.6
Average weekly red wine intake	0.3	0.4	1.3	1.0	0.2	1.1	-0.3	0.3	-0.6	-0.5
Back pain experienced in last month	0.3	0.5	2.1	0.4	0.9	0.3	0.3	0.2	0.0	-1.5
Osteoporosis (self-reported)	0.3	0.4	1.0	0.6	0.1	0.3	-0.4	-0.3	0.9	1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	0.1	-0.2	-1.3	-0.5	-0.2	-0.4	-0.5
Smoking status: Current	0.3	0.4	2.2	1.5	-0.0	0.5	-0.1	0.5	-0.2	-0.2
Wears glasses or contact lenses	0.3	0.3	0.8	-0.9	-0.4	0.6	0.2	-0.5	-0.9	-0.1
Commuting to job workplace: Public transport	0.3	0.4	1.7	0.4	-0.3	-0.6	-0.4	0.1	-1.3	0.6
Leg fat percentage (left)	0.3	1.1	3.1	-1.8	-1.3	1.1	0.1	-1.2	-0.6	-0.1
Diastolic blood pressure, automated reading	0.3	1.0	3.2	0.2	1.1	0.9	0.3	0.8	1.1	-1.8
Myopia	0.3	0.5	2.0	0.1	-0.4	1.0	-0.0	0.2	1.4	0.2
Pain experienced in last month	0.3	0.6	2.0	0.6	1.0	0.1	0.1	1.4	-0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	0.3	-0.6	-0.6	-0.4	0.1	-1.0	-0.5
Leg fat mass (left)	0.3	1.1	3.8	-2.0	-1.0	0.4	0.2	-1.3	-0.9	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-0.5	-1.0	-0.4	-0.4	-0.9	-0.4	0.8
Breast Cancer	0.2	0.5	1.4	-0.9	0.1	0.9	0.6	-0.0	-1.2	-0.4
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.8	-0.3	-0.4	-0.3	-1.0	-0.3	-0.3
Heel T-Score	0.2	1.2	2.2	-0.6	-1.4	-0.8	-1.5	-1.2	-0.3	1.3
Waist Hip Ratio (WHR)	0.2	0.9	2.9	-0.2	0.8	-0.4	0.9	0.8	1.1	-1.7
Neuroticism	0.2	0.4	2.0	-1.4	-0.3	-0.5	0.2	-0.4	-0.2	0.5
Chronotype (morning person)	0.2	0.4	1.8	0.5	0.1	-1.4	-0.1	0.3	0.1	-0.6
Sensitivity / hurt feelings	0.2	0.4	1.8	-1.4	-0.6	0.5	-0.3	-0.4	0.4	-0.0
Systolic blood pressure, automated reading	0.2	0.7	2.7	0.6	0.6	0.4	-1.0	0.3	0.3	-1.6
Fed-up feelings	0.2	0.4	1.3	0.7	-0.6	0.1	-0.8	-0.3	0.5	1.2
Relative age voice broke	0.2	0.2	0.6	0.6	0.2	-0.7	0.1	0.8	0.3	0.3
Qualifications: CSEs or equivalent	0.2	0.2	0.9	-0.4	-0.4	-0.9	-0.1	-0.3	0.4	-0.4
Body mass index (BMI)	0.2	1.0	3.0	-1.7	-1.2	0.3	-0.1	-1.5	-0.7	0.0
Nervous feelings	0.2	0.4	1.3	-0.5	-0.8	0.3	-0.3	-1.1	-0.5	0.5
Weight	0.2	0.8	2.3	-1.5	-0.5	-0.4	0.4	-0.9	-1.0	-1.1
Impedance of arm (right)	0.2	0.7	1.5	0.6	0.5	0.7	1.2	1.2	0.7	-0.6
Arm fat percentage (right)	0.2	0.6	2.2	-1.5	-1.0	0.5	0.7	-0.8	-0.3	-0.2
Impedance of arm (left)	0.2	1.0	2.2	1.1	0.9	0.4	1.2	1.5	0.9	-0.8
Arm fat mass (right)	0.2	0.8	2.8	-1.7	-0.8	0.3	0.6	-0.9	-0.6	-0.6
Peak expiratory flow (PEF)	0.2	0.4	2.2	0.3	0.1	1.5	-0.7	-0.3	0.0	-0.3
Headache pain in last month	0.2	0.4	1.0	0.4	0.0	-1.0	0.1	-0.4	0.9	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	-0.2	0.1	0.8	0.6	0.1	-1.2	-0.2
Birth weight	0.2	0.5	2.1	1.0	-0.1	0.0	-0.1	0.5	1.4	-0.6
Comparative body size at age 10	0.2	0.5	2.0	-0.3	-0.2	-1.4	0.9	0.3	-0.5	0.1
Number of full brothers	0.2	0.3	0.8	-0.5	0.5	0.9	-0.1	-0.0	0.1	-0.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.8	-0.5	0.7	0.4	0.2	-0.8	-0.0
Neck or shoulder pain in last month	0.2	0.3	0.5	0.4	-0.5	0.6	-0.7	-0.4	0.5	-0.6
Medication: Allopurinol	0.2	0.2	0.4	-0.5	-0.5	0.1	-0.5	-0.6	-0.6	-0.4
Comparative height size at age 10	0.2	1.0	2.0	-1.1	1.1	1.4	0.8	0.3	-1.0	-0.9
Suffer from ‘nerves’	0.2	0.3	1.1	-0.1	-1.1	0.1	0.1	-0.6	-0.8	0.5
Leg pain on walking	0.2	0.2	0.7	-0.3	-0.4	-0.8	-0.1	0.1	-0.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	-0.3	-0.4	-1.0	0.4	0.0	-0.2	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.0	0.5	-0.6	0.6	0.5	-0.3	0.4
Arm fat mass (left)	0.2	0.7	2.5	-1.6	-0.8	0.1	0.6	-0.9	-0.7	-0.4
Medication: Blood pressure	0.2	0.3	1.2	-1.1	-0.0	-0.4	0.0	-0.4	0.2	-0.9
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.5	0.0	0.7	-0.1	-0.1	-0.1	-1.1
Pack years of smoking	0.2	0.3	0.9	-0.7	-0.1	-0.5	0.2	-0.3	-1.0	0.5
Impedance of whole body	0.2	1.1	2.5	1.1	0.9	0.7	1.1	1.6	0.8	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.8	-0.2	0.2	-0.8	-0.3	0.5	0.8
Worry (Nagel 2018)	0.1	0.2	0.6	-0.4	0.1	-0.7	0.8	0.2	-0.1	0.1
Age at First Birth	0.1	0.1	0.6	-0.3	-0.3	-0.1	-0.1	-0.0	0.0	0.8
Blood Red Count	0.1	1.4	3.6	-0.2	-1.9	-0.7	-1.4	-1.7	-1.0	0.4
BMI	0.1	0.4	1.2	-0.9	-0.8	0.2	-0.1	-1.1	-0.2	-0.5
Height	0.1	2.2	6.6	0.5	0.2	-2.6	-0.8	-0.1	-1.4	-2.5
Smoking Status	0.1	0.3	0.9	0.7	-0.4	-0.7	0.2	0.6	0.9	-0.3
Lung FVC	0.1	0.5	2.5	0.5	0.3	0.0	0.4	-0.5	0.1	1.6
Pack years adult smoking proportion	0.1	0.1	0.3	-0.1	0.3	-0.5	0.1	0.0	-0.4	0.1
Impedance of leg (right)	0.1	0.7	1.9	0.0	0.5	1.3	0.9	1.4	0.2	-0.1
Leg fat-free mass (left)	0.1	0.6	2.2	-0.6	-0.2	-1.5	-0.4	-0.8	-0.7	-0.8
Current tobacco smoking	0.1	0.2	1.0	1.0	-0.2	0.5	-0.1	0.2	-0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.7	0.2	-0.5	0.1	0.8	0.6	-0.2
Sitting height	0.1	0.4	1.4	-1.2	0.4	-0.1	0.9	0.0	-0.7	0.0
Impedance of leg (left)	0.1	0.7	1.7	0.4	0.6	1.2	1.0	1.3	0.3	-0.3
Leg predicted mass (left)	0.1	0.6	2.1	-0.6	-0.2	-1.4	-0.4	-0.8	-0.6	-0.8
Hearing difficulty/problems with background noise	0.1	0.2	1.1	-0.3	-0.0	0.2	1.1	0.4	0.4	0.0
Had menopause	0.1	0.2	0.6	0.1	-0.4	0.1	-0.0	-0.4	-0.8	0.3
Had other major operations	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.2	-0.6	0.0	0.6
Forced vital capacity (FVC)	0.1	0.5	1.3	0.8	0.9	-1.1	0.7	0.2	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.5	0.4	-0.4	0.3	0.8	0.3	0.6
Qualifications: None of the above	0.1	0.3	1.6	0.4	0.1	-0.3	-1.2	-0.4	0.2	0.2
Neuroticism score	0.1	0.2	0.6	-0.8	-0.6	-0.4	0.1	-0.5	0.3	0.4
Trunk fat-free mass	0.1	0.6	2.1	-0.6	-0.2	-1.4	-0.2	-0.5	-1.2	-0.2
Hip circumference	0.1	0.3	0.9	-0.9	-0.2	-0.3	0.2	-0.5	-0.4	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	0.4	0.3	0.5	0.4	-0.4	-0.5	0.2
Prospective memory result	0.1	0.2	0.7	0.0	-0.2	-0.0	-0.3	-0.3	-0.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.2	0.1	-0.2	0.7	-0.1	-1.1	-0.5	-0.0
Trunk predicted mass	0.1	0.6	2.4	-0.5	-0.2	-1.6	-0.2	-0.5	-1.2	-0.1
Standing height	0.1	1.4	4.1	0.1	0.9	-1.5	0.9	0.9	-1.0	-2.0
Tense / ‘highly strung’	0.1	0.2	0.9	-0.3	-0.1	0.3	0.9	0.3	-0.2	-0.1
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.2	-0.9	0.3	-0.7	-0.3	0.1	0.9
Pulse wave reflection index	0.1	0.2	0.6	-0.2	0.7	-0.0	0.6	0.4	-0.0	-0.2
High blood pressure (siblings)	0.1	0.2	0.4	0.0	0.0	0.6	0.4	0.1	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.7	0.6	-0.7	0.3	-0.2	0.1	-0.4
Arm fat-free mass (right)	0.1	0.7	2.4	-0.4	-0.1	-1.5	-0.6	-0.6	-1.0	-0.7
Arm predicted mass (right)	0.1	0.4	1.5	-0.4	0.2	-1.2	-0.2	-0.4	-0.7	-0.8
Number of full sisters	0.1	0.2	0.7	-0.0	-0.3	0.3	0.8	0.2	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.5	0.2	-0.2	0.3	0.1	-0.4	-0.8
Whole body fat-free mass	0.1	0.6	2.3	-0.6	-0.2	-1.5	-0.4	-0.7	-0.9	-0.4
Leg fat-free mass (right)	0.1	0.7	2.9	-0.3	-0.2	-1.7	-0.6	-0.9	-0.5	-0.6
Arm fat percentage (left)	0.1	0.5	1.6	-1.3	-0.8	0.2	0.7	-0.7	-0.2	-0.2
Medication for cholesterol	0.1	0.1	0.4	0.3	-0.1	0.7	0.4	0.2	0.5	-0.2
Whole body water mass	0.1	0.6	2.6	-0.5	-0.1	-1.6	-0.3	-0.5	-0.8	-0.5
Leg predicted mass (right)	0.1	0.6	2.8	-0.2	-0.1	-1.7	-0.5	-0.7	-0.5	-0.7
Hearing aid user	0.1	0.1	0.4	0.1	0.0	-0.2	0.3	0.0	-0.6	-0.1
Basal metabolic rate	0.1	0.6	1.7	-0.8	-0.2	-1.3	-0.1	-0.7	-0.9	-0.6
Arm fat-free mass (left)	0.1	0.5	1.1	-0.5	-0.4	-1.1	-0.4	-0.7	-1.0	-0.5
Irritability	0.1	0.2	0.3	-0.6	-0.3	0.4	0.6	-0.0	-0.3	0.5
Arm predicted mass (left)	0.1	0.6	1.4	-0.7	-0.5	-0.8	-0.5	-1.0	-1.2	-0.2
Blood White Count	0.0	0.3	0.9	0.5	-0.8	-1.0	-0.7	-0.3	-0.3	-0.0
Hair Pigment	0.0	0.2	0.6	0.7	0.2	0.2	0.2	0.8	0.1	-0.4
Tanning	0.0	0.3	1.0	-1.0	0.1	-0.2	0.4	-0.1	0.9	0.2

Hub : Genes

CHI3L2

Models

Trait associations