Hub : Genes

CHI3L2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Spleen 0.4060 0.1210 1.8e-03 0.265 NA 0.154 NA 0.256 1.7e-07 NA 9.4e-05 NA 2.9e-07
2 GTEx Whole Blood 0.3150 0.0630 2.2e-08 0.229 NA 0.215 NA 0.214 6.1e-21 NA 1.3e-19 NA 1.7e-19
3 METSIM Adipose 0.0372 0.0165 8.3e-03 0.006 0.013 0.002 0.013 0.005 3.2e-02 3.8e-03 1.5e-01 3.4e-03 4.5e-02
4 NTR Blood 0.0536 0.0150 5.0e-07 0.042 0.024 0.053 0.047 0.050 2.0e-13 1.8e-08 8.9e-17 7.9e-15 6.9e-16
5 YFS Blood 0.5650 0.0338 0.0e+00 0.360 0.436 0.478 0.469 0.486 1.4e-124 3.2e-159 1.4e-180 7.5e-176 1.8e-184
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0515 0.0231 6.7e-04 0.012 0.037 0.033 NA 0.026 1.6e-02 4.5e-05 1.1e-04 NA 5.6e-04
7 TCGA Thyroid Carcinoma 0.1110 0.0370 1.8e-06 0.035 0.048 0.093 NA 0.081 2.1e-04 1.7e-05 2.2e-09 NA 2.4e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 3.2 1.8 0.3 -0.6 0.1 0.8 0.7 0.7
Bipolar Disorder or Schizophrenia 0.4 1.0 2.6 -0.0 1.2 0.9 1.6 0.7 1.2 -0.5
Depressed Affect (Nagel 2018) 0.4 0.9 1.8 0.1 -1.1 -0.7 -1.0 -1.1 0.5 1.4
Depression (Nagel 2018) 0.6 0.9 3.3 0.6 -1.3 -0.6 -0.6 -0.6 0.2 1.8
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.7 -0.8 -0.2 0.2 -0.8 -0.3 0.5 0.8
Neuroticism (Nagel 2018) 0.2 0.5 1.0 -0.5 -1.0 -0.4 -0.4 -0.9 -0.4 0.8
Schizophrenia (2018) 0.9 1.9 4.1 -1.5 1.2 1.7 2.0 0.2 1.0 -1.3
Schizophrenia vs Biploar Disorder 0.6 0.8 1.6 -0.5 1.1 1.1 0.9 0.4 1.3 -0.8
Worry (Nagel 2018) 0.1 0.2 0.6 -0.4 0.1 -0.7 0.8 0.2 -0.1 0.1
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 0.3 1.0 -0.3 0.5 0.7 0.6 0.5
Alzheimer’s Disease (in father) 1.6 1.7 4.8 -1.6 -0.6 2.2 -0.2 -1.0 0.7 1.7
Alzheimer’s Disease (including proxy) 0.8 1.1 3.6 -0.2 0.9 1.9 0.7 0.4 1.4 0.7
Crohns Disease (2017) 0.8 1.7 5.1 -1.1 -0.5 1.6 0.9 -1.3 -0.1 2.3
Irritable Bowel Disease (IBD) 0.4 0.9 2.0 0.2 0.7 1.1 0.9 -0.2 1.4 1.3
Ulcerative Colitis (UC) 0.9 1.7 5.9 1.2 1.5 0.5 0.9 1.0 2.4 -0.6
Major Depression (MDD) 0.9 1.1 2.5 0.2 1.2 -0.9 1.6 0.7 0.2 -1.5
Reaction Time 1.2 2.2 4.0 1.9 1.3 2.0 1.6 1.2 1.5 -0.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.5 -0.8 -0.1 -1.6 -1.0 0.0 0.2 1.2
Breast Cancer 0.2 0.5 1.4 -0.9 0.1 0.9 0.6 -0.0 -1.2 -0.4
Ovarian Cancer 1.7 2.3 7.7 -2.8 -1.1 2.1 1.1 -0.8 -0.9 -0.1
Prostate Cancer 0.8 1.1 2.8 0.5 1.3 -1.1 0.7 0.8 -0.6 -1.7
Age at First Birth 0.1 0.1 0.6 -0.3 -0.3 -0.1 -0.1 -0.0 0.0 0.8
Bipolar Disorder (2011) 0.7 0.7 2.7 1.1 -0.0 -0.1 -0.2 0.1 0.8 1.7
Body Mass Index (BMI) (2010) 0.2 0.3 1.0 -0.8 -0.3 -0.4 -0.3 -1.0 -0.3 -0.3
Coronary Artery Disease (CAD) 1.9 2.2 7.4 0.9 1.8 0.6 1.0 1.6 2.7 -0.4
Crohns Disease (2012) 0.7 1.1 2.6 -0.7 -0.7 1.6 -0.0 -1.2 -0.2 1.6
Mean Putamen Volume 1.5 1.8 3.8 1.4 1.3 1.9 0.5 1.7 0.5 -1.2
Fasting Glucose 1.0 1.2 3.7 1.3 -0.6 0.4 -1.9 -1.0 -0.5 -1.0
HbA1C 1.4 1.6 3.9 2.0 1.3 -1.5 0.3 1.0 0.5 -1.3
HDL Cholesterol 0.3 0.5 1.6 -0.4 -0.8 0.3 -0.7 -0.8 -0.2 1.2
LDL Cholesterol 0.8 1.2 2.2 -0.7 -1.5 0.2 -1.3 -1.3 -1.4 0.5
Lupus 0.3 0.4 1.0 -1.0 0.2 -0.4 0.8 0.3 0.9 -0.6
Neuroticism (2016) 0.4 0.5 2.0 -0.6 0.5 0.7 1.4 0.9 0.1 -0.3
Primary Biliary Cirrhosis 0.4 0.6 2.0 -1.1 -0.4 -1.4 0.5 0.0 -0.8 -0.5
Rheumatoid Arthritis 1.1 1.5 3.6 1.4 -1.2 -1.3 -1.9 -0.9 -0.7 -0.8
Schizophrenia (2014) 0.8 1.8 2.9 -0.5 1.7 1.7 1.7 0.8 1.6 -0.9
Triglycerides 0.4 0.7 2.3 -1.5 -1.1 -0.4 -0.6 -0.7 -0.3 -0.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.7 0.5 -0.7 -1.3 -0.6 -0.2 0.0 0.7
Ulcerative Colitis 0.9 1.3 3.6 1.9 1.1 -0.2 -0.6 0.6 1.8 -0.7
Blood Eosinophil Count 0.5 4.2 19.6 0.4 -1.9 -4.4 -1.8 -1.2 -0.8 -0.5
Blood Platelet Count 0.6 7.2 30.6 1.8 -0.6 -5.5 -3.2 0.3 2.3 0.5
Blood Red Count 0.1 1.4 3.6 -0.2 -1.9 -0.7 -1.4 -1.7 -1.0 0.4
Blood White Count 0.0 0.3 0.9 0.5 -0.8 -1.0 -0.7 -0.3 -0.3 -0.0
Heel T-Score 0.2 1.2 2.2 -0.6 -1.4 -0.8 -1.5 -1.2 -0.3 1.3
BMI 0.1 0.4 1.2 -0.9 -0.8 0.2 -0.1 -1.1 -0.2 -0.5
Height 0.1 2.2 6.6 0.5 0.2 -2.6 -0.8 -0.1 -1.4 -2.5
Waist Hip Ratio (WHR) 0.2 0.9 2.9 -0.2 0.8 -0.4 0.9 0.8 1.1 -1.7
Systolic Blood Pressure 0.3 1.4 4.8 1.0 0.7 1.6 -0.1 1.2 0.2 -2.2
Smoking Status 0.1 0.3 0.9 0.7 -0.4 -0.7 0.2 0.6 0.9 -0.3
Allergy or Eczema 0.4 1.0 2.3 1.3 0.7 0.2 0.3 1.1 1.5 1.0
Cardiovascular Disease 0.3 1.1 4.6 -1.3 -0.1 -0.4 0.5 0.6 -0.8 -2.1
Hypothyroidism (self reported) 0.3 0.8 3.9 -0.7 -0.2 0.1 0.0 -0.4 -2.0 -0.8
Respiratory disease 0.5 1.1 4.9 2.2 0.3 0.5 0.2 1.2 1.0 0.6
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.1 -1.4 -0.0 1.5 0.8 -0.1 -0.5 0.6
Lung FEV1/FVC ratio 1.3 6.7 33.5 -1.7 -1.1 5.8 0.3 -1.9 -2.0 1.0
Lung FVC 0.1 0.5 2.5 0.5 0.3 0.0 0.4 -0.5 0.1 1.6
Neuroticism 0.2 0.4 2.0 -1.4 -0.3 -0.5 0.2 -0.4 -0.2 0.5
Chronotype (morning person) 0.2 0.4 1.8 0.5 0.1 -1.4 -0.1 0.3 0.1 -0.6
Hair Pigment 0.0 0.2 0.6 0.7 0.2 0.2 0.2 0.8 0.1 -0.4
Tanning 0.0 0.3 1.0 -1.0 0.1 -0.2 0.4 -0.1 0.9 0.2
Hand grip strength (left) 1.0 2.6 6.5 0.3 -1.9 -1.5 -2.5 -1.9 -1.4 0.7
Number of treatments/medications taken 1.2 2.2 6.0 -2.5 -1.2 1.2 1.3 -1.0 -1.7 0.9
Average weekly spirits intake 0.5 0.6 1.1 -0.6 0.7 1.0 0.9 0.6 0.3 -1.0
Sensitivity / hurt feelings 0.2 0.4 1.8 -1.4 -0.6 0.5 -0.3 -0.4 0.4 -0.0
Frequency of depressed mood in last 2 weeks 2.1 3.0 10.4 -0.1 -2.3 0.3 -1.4 -1.8 -0.3 3.2
Hearing difficulty/problems: Yes 0.5 0.7 1.9 -0.9 0.5 0.6 1.4 0.6 -0.1 -1.1
Relative age of first facial hair 0.3 0.6 2.2 1.5 0.4 -0.6 -0.9 0.3 -0.5 -0.5
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.6 -1.0 0.5 1.1 1.6 1.1 1.0 0.5
Ever used hormone-replacement therapy (HRT) 1.1 1.5 2.7 -0.8 -0.8 0.1 -1.6 -1.6 -1.3 1.5
Ever had hysterectomy (womb removed) 1.5 1.7 5.7 -2.4 -1.5 -0.3 -0.2 -1.7 -0.2 1.0
Systolic blood pressure, automated reading 0.2 0.7 2.7 0.6 0.6 0.4 -1.0 0.3 0.3 -1.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.6 -0.4 -0.9 0.9 -0.5 -0.7 -1.6 0.3
Angina 0.7 1.0 3.6 -1.7 -0.3 -0.1 0.0 -0.4 -1.9 0.0
Medication for hormone replacement therapy 1.0 1.1 2.5 -0.7 -0.9 -0.5 -0.7 -1.4 -1.6 1.1
Vitamin and mineral supplements 1.0 1.4 4.7 0.7 0.5 -2.2 -0.4 0.5 1.9 -0.3
Supplements: Zinc 1.1 1.2 2.0 1.4 1.0 1.4 0.8 1.4 0.9 -0.1
Medication: Co-codamol 0.5 0.6 1.5 -0.9 0.2 1.2 0.5 -0.0 0.8 -0.8
Medication: Metformin 1.2 1.6 4.7 -2.2 -1.0 1.1 1.1 -0.4 -1.7 0.5
Diabetes (father) 0.4 0.5 1.4 0.0 0.7 0.4 0.3 0.1 -1.2 -1.1
Diabetes (mother) 1.0 1.3 2.4 -1.5 -1.1 1.5 0.5 -0.7 -1.2 0.9
Severe depression (siblings) 2.4 2.7 6.6 -2.0 -2.0 0.5 -1.4 -2.6 -1.1 1.0
Pack years adult smoking proportion 0.1 0.1 0.3 -0.1 0.3 -0.5 0.1 0.0 -0.4 0.1
Impedance of leg (right) 0.1 0.7 1.9 0.0 0.5 1.3 0.9 1.4 0.2 -0.1
Leg fat-free mass (left) 0.1 0.6 2.2 -0.6 -0.2 -1.5 -0.4 -0.8 -0.7 -0.8
Trunk fat percentage 0.3 1.2 4.4 -2.1 -1.0 0.9 0.5 -1.0 -0.5 -0.7
Hand grip strength (right) 0.5 1.3 3.6 1.2 -0.4 -1.9 -1.5 -0.4 -0.7 -0.9
Townsend deprivation index at recruitment 0.5 0.7 1.5 1.0 1.2 0.3 0.4 1.2 0.4 -0.5
Current tobacco smoking 0.1 0.2 1.0 1.0 -0.2 0.5 -0.1 0.2 -0.2 0.2
Average weekly fortified wine intake 0.3 0.4 0.9 0.3 -0.5 1.0 0.7 0.7 -0.5 -0.1
Maternal smoking around birth 0.6 0.9 2.7 0.8 0.6 -1.1 0.1 1.0 0.1 -1.6
Fed-up feelings 0.2 0.4 1.3 0.7 -0.6 0.1 -0.8 -0.3 0.5 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.3 0.8 0.2 0.5 0.4 0.4 0.3 1.1
Relative age voice broke 0.2 0.2 0.6 0.6 0.2 -0.7 0.1 0.8 0.3 0.3
Taking other prescription medications 1.3 2.0 5.7 -2.1 -0.2 2.4 1.8 -0.4 -0.4 0.2
Age when periods started (menarche) 0.4 0.9 2.4 -1.5 -0.5 0.6 -0.8 -1.3 -1.1 -0.3
Bilateral oophorectomy (both ovaries removed) 2.7 3.1 6.0 -1.6 -2.1 -0.7 -1.5 -2.5 -2.0 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 0.7 0.2 -0.5 0.1 0.8 0.6 -0.2
Tinnitus: Yes, but not now, but have in the past 3.9 4.2 7.7 -2.1 -2.8 -0.3 -2.0 -2.6 -2.0 1.6
Qualifications: CSEs or equivalent 0.2 0.2 0.9 -0.4 -0.4 -0.9 -0.1 -0.3 0.4 -0.4
Serious illness, injury or assault to yourself 0.4 0.4 1.1 0.0 -1.1 -0.6 -0.6 -0.8 -0.7 0.0
High blood pressure 0.4 1.0 2.7 -1.6 -0.9 0.2 0.1 -0.6 -1.2 -1.3
Hayfever, allergic rhinitis or eczema 0.7 1.6 3.3 1.8 1.0 -0.3 0.2 1.7 1.4 1.3
Multivitamins +/- minerals 1.1 1.4 3.5 -0.2 -1.0 1.2 -1.3 -0.9 -1.9 1.3
Stomach or abdominal pain in last month 1.0 1.2 2.8 -1.7 -0.8 -1.5 -0.1 -1.0 -1.4 0.3
Supplements: Glucosamine 0.6 0.7 1.5 -0.2 -1.2 1.0 -1.0 -0.9 -0.8 0.3
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 7.3 2.7 1.6 1.0 0.5 1.5 0.7 -1.1
Medication: Atenolol 0.3 0.4 0.8 -0.7 0.3 -0.9 0.1 -0.3 -0.8 -0.9
Medication: Levothyroxine sodium 0.3 0.5 2.6 -0.2 0.1 0.5 0.5 0.1 -1.6 -0.2
Sitting height 0.1 0.4 1.4 -1.2 0.4 -0.1 0.9 0.0 -0.7 0.0
Chronic bronchitis/emphysema (father) 0.5 0.6 2.2 1.5 0.2 -0.8 -0.1 1.0 0.3 -0.2
High blood pressure (mother) 0.7 1.0 2.7 -1.6 -0.4 1.1 1.1 0.0 -0.6 -1.2
Body mass index (BMI) 0.2 1.0 3.0 -1.7 -1.2 0.3 -0.1 -1.5 -0.7 0.0
Impedance of leg (left) 0.1 0.7 1.7 0.4 0.6 1.2 1.0 1.3 0.3 -0.3
Leg predicted mass (left) 0.1 0.6 2.1 -0.6 -0.2 -1.4 -0.4 -0.8 -0.6 -0.8
Trunk fat mass 0.3 1.2 4.1 -2.0 -1.0 0.5 0.4 -1.1 -0.8 -0.8
Waist circumference 0.3 1.0 3.6 -1.1 0.5 0.0 1.4 0.2 0.3 -1.9
Number of incorrect matches in round 1.1 1.9 4.3 -0.5 2.1 1.1 2.0 1.7 0.7 0.1
Past tobacco smoking 0.6 1.1 3.9 -0.4 -0.5 1.1 -1.0 -1.0 -2.0 0.6
Alcohol usually taken with meals 0.5 0.7 1.9 0.8 -0.5 -1.4 -1.3 -0.5 -0.5 -0.3
Nervous feelings 0.2 0.4 1.3 -0.5 -0.8 0.3 -0.3 -1.1 -0.5 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 3.6 0.0 -1.9 0.4 -0.3 -1.1 -0.8 1.5
Hearing difficulty/problems with background noise 0.1 0.2 1.1 -0.3 -0.0 0.2 1.1 0.4 0.4 0.0
Hair/balding pattern: Pattern 2 0.5 0.6 1.8 -1.1 0.5 0.3 1.3 -0.6 -0.8 0.1
Had menopause 0.1 0.2 0.6 0.1 -0.4 0.1 -0.0 -0.4 -0.8 0.3
Had other major operations 0.1 0.2 0.4 0.3 -0.4 -0.4 -0.2 -0.6 0.0 0.6
Forced vital capacity (FVC) 0.1 0.5 1.3 0.8 0.9 -1.1 0.7 0.2 -0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.6 0.5 0.4 -0.4 0.3 0.8 0.3 0.6
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 4.8 -1.4 -0.0 1.6 2.2 -0.2 -0.3 0.1
Qualifications: None of the above 0.1 0.3 1.6 0.4 0.1 -0.3 -1.2 -0.4 0.2 0.2
Financial difficulties in last 2 years 0.8 1.1 2.5 1.6 0.6 -0.5 0.9 1.2 1.5 -0.4
Mouth/teeth dental problems 0.9 1.3 4.7 1.5 -0.5 -0.8 -2.2 -0.8 0.4 0.7
Heart attack 1.2 1.5 3.8 -2.0 -1.4 -0.3 -1.3 -1.6 -0.6 0.2
Allergy 0.7 1.6 5.0 -2.2 -0.8 0.5 0.3 -1.6 -1.2 -1.1
Pain all over the body in last month 1.2 1.3 5.9 -0.7 -0.7 2.4 -0.1 -0.6 0.7 1.1
Diabetes (self-reported) 1.3 2.0 4.8 -2.1 -0.4 2.2 0.5 -0.8 -1.9 0.5
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 3.8 1.9 0.5 1.0 0.5 1.0 0.8 -0.1
Medication: Ramipril 0.8 1.0 2.2 -1.2 -0.9 -1.2 -0.1 -0.9 -1.5 0.1
Medication: Simvastatin 1.1 1.6 5.9 -0.4 0.4 0.8 1.0 0.7 -1.8 -2.4
Fluid intelligence score 0.4 0.8 1.8 -0.8 1.3 -0.3 1.0 1.3 -0.3 -0.1
Illnesses of siblings 0.3 0.5 1.7 -0.5 -0.2 -1.3 -0.4 -0.5 -0.8 0.4
Neuroticism score 0.1 0.2 0.6 -0.8 -0.6 -0.4 0.1 -0.5 0.3 0.4
Weight 0.2 0.8 2.3 -1.5 -0.5 -0.4 0.4 -0.9 -1.0 -1.1
Impedance of arm (right) 0.2 0.7 1.5 0.6 0.5 0.7 1.2 1.2 0.7 -0.6
Arm fat percentage (right) 0.2 0.6 2.2 -1.5 -1.0 0.5 0.7 -0.8 -0.3 -0.2
Trunk fat-free mass 0.1 0.6 2.1 -0.6 -0.2 -1.4 -0.2 -0.5 -1.2 -0.2
Hip circumference 0.1 0.3 0.9 -0.9 -0.2 -0.3 0.2 -0.5 -0.4 -0.6
Time employed in main current job 1.8 2.1 5.3 -1.6 -1.7 0.3 -0.4 -1.7 -2.3 0.9
Alcohol intake versus 10 years previously 0.8 1.3 6.5 -0.5 -0.4 -0.2 0.0 -1.2 -2.5 0.6
Father’s age at death 0.8 1.1 2.4 0.9 0.3 -1.4 1.1 0.3 1.5 0.8
Worrier / anxious feelings 0.7 1.3 3.1 -0.3 -1.4 -1.3 -1.1 -0.9 0.5 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 5.3 -1.4 -0.7 0.4 1.0 -0.2 0.6 2.3
Falls in the last year 0.4 0.5 1.2 -0.7 -1.1 1.0 0.4 -0.3 -0.4 0.6
Hair/balding pattern: Pattern 3 0.8 1.2 3.1 1.4 1.2 -0.4 0.2 1.8 1.1 -0.3
Number of live births 1.6 2.2 4.3 1.1 2.1 1.6 1.4 1.8 1.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.3 0.4 0.3 0.5 0.4 -0.4 -0.5 0.2
Pulse rate 1.7 2.8 5.6 -0.9 2.2 1.7 2.4 1.6 1.3 -1.2
Happiness 0.3 0.4 0.8 0.7 -0.6 -0.5 -0.5 -0.4 0.3 0.9
Noisy workplace 2.4 3.0 8.1 -2.8 -1.9 0.2 -0.4 -2.4 -1.3 1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.3 0.0 1.1 0.0 1.5 1.2 0.2 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 0.1 0.2 -0.8 -0.6 -0.6 -0.6 -0.8
Mouth/teeth dental problems: Dentures 2.2 3.6 7.1 -0.7 2.4 0.8 2.7 2.3 0.5 -2.5
Asthma 0.5 1.0 2.8 1.7 0.9 1.0 0.6 1.3 0.8 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.4 -1.0 -0.7 1.1 -0.9 -1.2 0.9 -0.5
Medication: Cholesterol lowering 1.1 1.7 2.7 -1.6 -0.8 1.6 0.8 0.1 -1.6 -1.6
Depression (self-reported) 0.4 0.4 1.4 0.1 0.7 -0.1 1.2 0.6 -0.4 -0.8
Medication: Lansoprazole 1.2 1.3 3.6 -0.2 1.4 1.9 1.1 0.8 1.0 -0.9
Prospective memory result 0.1 0.2 0.7 0.0 -0.2 -0.0 -0.3 -0.3 -0.4 -0.9
Lung cancer (father) 0.7 0.9 1.7 0.8 -0.8 -0.2 -1.3 -0.9 1.3 0.9
Illnesses of mother 0.3 0.4 1.9 0.7 0.3 -0.3 -1.4 -0.3 0.2 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.2 0.1 -0.2 0.7 -0.1 -1.1 -0.5 -0.0
Pulse wave Arterial Stiffness index 0.7 0.8 3.3 -1.8 0.9 0.1 0.9 0.4 -0.5 -0.6
Impedance of arm (left) 0.2 1.0 2.2 1.1 0.9 0.4 1.2 1.5 0.9 -0.8
Arm fat mass (right) 0.2 0.8 2.8 -1.7 -0.8 0.3 0.6 -0.9 -0.6 -0.6
Trunk predicted mass 0.1 0.6 2.4 -0.5 -0.2 -1.6 -0.2 -0.5 -1.2 -0.1
Standing height 0.1 1.4 4.1 0.1 0.9 -1.5 0.9 0.9 -1.0 -2.0
Length of working week for main job 0.4 0.5 2.2 0.5 0.1 -0.2 -0.1 0.2 0.8 1.5
Exposure to tobacco smoke at home 1.6 1.8 4.5 -0.3 -0.9 -0.3 -2.1 -1.7 -2.1 -0.3
Breastfed as a baby 0.5 0.6 1.2 1.1 0.1 -1.0 -0.8 0.5 1.0 0.4
Tense / ‘highly strung’ 0.1 0.2 0.9 -0.3 -0.1 0.3 0.9 0.3 -0.2 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 5.5 2.0 -0.3 0.2 0.3 0.5 2.4 1.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.9 0.2 -0.9 0.3 -0.7 -0.3 0.1 0.9
Birth weight of first child 1.4 2.6 10.6 1.1 -1.3 -1.6 -3.3 -0.9 -0.7 0.7
Peak expiratory flow (PEF) 0.2 0.4 2.2 0.3 0.1 1.5 -0.7 -0.3 0.0 -0.3
Pulse wave reflection index 0.1 0.2 0.6 -0.2 0.7 -0.0 0.6 0.4 -0.0 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.9 -0.9 -0.4 0.4 0.8 -0.3 -0.5 1.0
Loud music exposure frequency 0.5 0.6 2.0 0.6 0.2 -0.4 1.1 0.6 -0.1 1.4
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.8 -0.5 0.8 -0.3 1.3 0.6 0.3 -0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 1.9 -0.8 -1.4 -0.0 -0.4 -1.3 -0.9 1.3
Blood clot in the leg (DVT) 0.4 0.5 1.2 0.2 -0.9 -1.0 -0.8 -0.1 -1.1 -0.4
Medication: Paracetamol 0.8 1.4 4.4 -0.6 0.3 1.1 1.2 0.0 1.5 2.1
Headache pain in last month 0.2 0.4 1.0 0.4 0.0 -1.0 0.1 -0.4 0.9 0.8
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 5.6 2.4 1.1 -0.6 -0.8 0.3 1.7 1.2
Glaucoma (self-reported) 1.8 2.2 4.8 2.2 1.9 0.1 1.2 1.5 1.1 -1.3
Gout (self-reported) 0.5 0.7 1.9 -1.4 -0.4 0.6 -0.4 -1.2 -0.5 -0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.6 -0.2 0.1 0.8 0.6 0.1 -1.2 -0.2
Medication: Amlodipine 1.1 1.5 2.9 -1.3 -1.6 0.7 -0.3 -1.7 -1.6 0.8
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.8 1.4 0.1 -0.0 -0.0 0.5 0.6 1.3
Birth weight 0.2 0.5 2.1 1.0 -0.1 0.0 -0.1 0.5 1.4 -0.6
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.3 -0.9 0.1 0.9 -0.0 -1.2 0.1 -0.1
High blood pressure (siblings) 0.1 0.2 0.4 0.0 0.0 0.6 0.4 0.1 0.6 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.2 0.5 0.7 0.6 -0.7 0.3 -0.2 0.1 -0.4
Body fat percentage 0.3 1.0 3.8 -1.9 -1.1 0.8 0.5 -1.0 -0.5 -0.4
Leg fat percentage (right) 0.4 1.5 5.2 -2.3 -1.4 1.1 0.2 -1.2 -0.7 0.1
Arm fat-free mass (right) 0.1 0.7 2.4 -0.4 -0.1 -1.5 -0.6 -0.6 -1.0 -0.7
Exposure to tobacco smoke outside home 0.7 0.9 2.8 1.0 -0.3 -1.7 -0.8 -0.4 -1.1 -0.6
Comparative body size at age 10 0.2 0.5 2.0 -0.3 -0.2 -1.4 0.9 0.3 -0.5 0.1
Number of full brothers 0.2 0.3 0.8 -0.5 0.5 0.9 -0.1 -0.0 0.1 -0.7
Worry too long after embarrassment 1.1 1.9 5.0 0.1 -2.2 0.9 -2.0 -1.6 -1.0 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.6 0.8 -0.3 0.6 0.0 -0.1 1.9 0.8
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 -0.8 -0.5 0.7 0.4 0.2 -0.8 -0.0
Number of children fathered 0.8 1.0 2.0 -1.4 -1.1 0.1 -0.8 -1.0 -1.4 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.0 -1.1 -1.0 -0.8 -0.6 -0.7 -1.4 -0.1
Age at first live birth 0.6 1.1 3.1 0.7 1.2 0.7 1.2 1.1 -0.1 -1.8
Pulse wave peak to peak time 0.6 0.7 2.9 1.7 -0.9 -0.4 -0.9 -0.4 0.3 0.3
Health satisfaction 0.3 0.4 1.3 -1.1 0.2 0.8 0.2 -0.3 0.8 0.2
Shortness of breath walking on level ground 0.4 0.4 1.2 -1.1 -1.1 -0.3 0.2 -0.6 -0.3 0.3
Qualifications: College or University degree 0.3 1.0 3.9 0.2 0.4 0.4 0.9 1.0 -1.1 2.0
Eye problems/disorders: None of the above 0.8 0.9 2.2 1.0 0.5 -1.3 0.2 1.2 1.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.1 0.3 -0.9 -0.6 -1.0 -1.1 -0.5 1.4
Emphysema/chronic bronchitis 0.3 0.4 1.0 -0.2 -0.8 -0.0 -0.6 -0.4 0.4 1.0
Medication for pain relief, constipation, heartburn 1.3 2.2 6.1 2.5 0.2 -1.5 -1.5 0.6 -1.5 -1.3
Neck or shoulder pain in last month 0.2 0.3 0.5 0.4 -0.5 0.6 -0.7 -0.4 0.5 -0.6
Medication: Blood pressure 1.5 2.7 8.0 -2.8 -2.0 0.2 -0.2 -1.6 -2.1 0.3
Angina (self-reported) 0.7 0.9 3.5 -1.6 0.1 0.1 0.3 -0.1 -1.9 -0.1
Migraine (self-reported) 1.6 2.0 6.2 -2.5 -0.0 1.5 1.6 -0.6 -1.6 0.5
Medication: Ibuprofen 0.5 0.6 1.4 -0.4 -0.7 0.8 -0.7 -0.7 1.2 -0.6
Medication: Allopurinol 0.2 0.2 0.4 -0.5 -0.5 0.1 -0.5 -0.6 -0.6 -0.4
Medication: Omeprazole 0.4 0.4 1.3 0.6 0.2 1.1 1.0 0.6 0.2 0.2
Medication: Seretide 50 evohaler 1.1 1.2 5.8 1.0 -0.7 -0.2 -0.8 -0.4 0.6 2.4
Mean time to correctly identify matches 1.2 2.3 5.8 1.4 1.1 2.4 1.5 1.1 1.8 -0.9
Heart disease (mother) 0.3 0.3 1.6 0.5 -0.2 1.3 -0.2 0.1 0.2 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.0 0.0 0.6 0.3 -0.1 0.1 1.4 0.5
Whole body fat mass 0.3 1.1 4.5 -2.1 -0.9 0.4 0.5 -1.0 -0.8 -0.6
Leg fat mass (right) 0.4 1.5 5.4 -2.3 -1.2 0.4 0.2 -1.4 -1.1 -0.3
Arm predicted mass (right) 0.1 0.4 1.5 -0.4 0.2 -1.2 -0.2 -0.4 -0.7 -0.8
Pulse rate, automated reading 1.9 6.2 10.0 -0.4 2.7 3.2 3.0 2.5 1.9 -2.6
Alcohol intake frequency. 0.4 1.0 2.3 -0.2 -1.1 -0.0 -1.1 -1.5 -1.5 0.3
Comparative height size at age 10 0.2 1.0 2.0 -1.1 1.1 1.4 0.8 0.3 -1.0 -0.9
Number of full sisters 0.1 0.2 0.7 -0.0 -0.3 0.3 0.8 0.2 0.5 0.3
Suffer from ‘nerves’ 0.2 0.3 1.1 -0.1 -1.1 0.1 0.1 -0.6 -0.8 0.5
Overall health rating 0.5 1.0 3.2 -1.4 -0.7 1.8 0.4 -0.2 1.0 0.5
Chest pain or discomfort 1.1 1.6 3.0 -1.7 -1.7 1.3 -0.3 -1.1 -0.2 1.6
Had major operations 1.8 2.2 5.3 -2.3 -1.5 1.3 0.1 -1.2 -1.1 1.8
Age at last live birth 0.9 1.2 2.4 1.4 1.1 0.7 1.5 1.4 -0.5 -0.6
Family relationship satisfaction 1.8 2.2 5.5 -0.8 -1.0 2.4 -0.5 -1.5 -1.6 1.7
Leg pain on walking 0.2 0.2 0.7 -0.3 -0.4 -0.8 -0.1 0.1 -0.5 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 1.0 -0.3 -0.4 -1.0 0.4 0.0 -0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.5 -0.6 -1.1 -0.3 -0.4 -1.1 -0.9 1.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.3 0.0 0.5 -0.6 0.6 0.5 -0.3 0.4
Medication: Aspirin 1.2 1.6 8.0 -2.8 -0.5 0.2 0.4 -1.2 -1.0 0.6
Supplements: Vitamin C 1.8 2.2 7.5 -1.2 -1.1 2.7 0.8 -1.0 -1.8 -0.3
Knee pain experienced in last month 1.9 2.9 6.8 -2.0 -2.2 -0.4 -1.6 -2.6 -1.3 0.9
Hypertension (Self-reported) 0.5 1.4 4.3 -2.1 -0.6 0.5 0.2 -0.6 -1.1 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.5 -0.4 0.4 0.9 1.2 0.4 1.2 -1.1
Illnesses of father: Heart disease 0.6 0.9 4.2 -0.1 0.4 2.0 0.9 0.2 -0.8 -0.3
Illnesses of siblings: Diabetes 0.4 0.5 1.5 -0.4 -1.2 1.1 -0.3 -0.3 -0.8 0.2
Smoking status: Previous 1.3 2.0 5.7 0.2 1.4 -0.5 1.7 1.3 2.4 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.7 0.5 0.2 -0.2 0.3 0.1 -0.4 -0.8
Whole body fat-free mass 0.1 0.6 2.3 -0.6 -0.2 -1.5 -0.4 -0.7 -0.9 -0.4
Leg fat-free mass (right) 0.1 0.7 2.9 -0.3 -0.2 -1.7 -0.6 -0.9 -0.5 -0.6
Arm fat percentage (left) 0.1 0.5 1.6 -1.3 -0.8 0.2 0.7 -0.7 -0.2 -0.2
Average weekly red wine intake 0.3 0.4 1.3 1.0 0.2 1.1 -0.3 0.3 -0.6 -0.5
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.4 -0.5 1.2 1.2 1.1 0.7 1.0 -1.0
Mood swings 0.5 0.8 1.9 1.3 -0.1 -1.0 -0.4 0.3 1.4 0.9
Loneliness, isolation 1.0 1.4 2.8 -1.1 -1.6 0.4 -0.8 -1.7 -0.7 1.4
Long-standing illness, disability or infirmity 0.9 1.3 3.1 -1.2 -0.4 1.7 1.2 0.1 0.2 1.8
Ever had bowel cancer screening 1.3 1.5 3.0 -1.6 0.0 1.4 1.4 -0.3 1.0 1.7
Diabetes diagnosed by doctor 1.0 1.6 5.2 -1.7 -0.1 2.3 0.7 -0.4 -1.5 0.7
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.4 5.0 1.7 1.2 -1.1 1.5 2.2 2.1 -0.3
Friendships satisfaction 0.5 0.6 1.3 1.1 0.4 1.1 -0.2 0.3 -1.1 0.6
Qualifications: nursing, teaching 0.5 0.8 2.6 0.9 -0.4 -1.6 -0.1 0.1 -0.6 1.2
Commuting to job workplace: Walk 1.6 1.7 3.7 0.9 1.6 0.9 1.0 1.9 0.7 -1.6
Eye problems/disorders: Cataract 2.4 2.8 6.2 -1.2 -2.0 1.1 -2.0 -2.5 -1.3 1.2
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.5 -2.1 -0.3 0.2 1.7 0.2 -0.3 -0.2
Medication for cholesterol 0.1 0.1 0.4 0.3 -0.1 0.7 0.4 0.2 0.5 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 -0.2 -0.9 0.7 0.2 -0.8 -0.8 0.5
Back pain experienced in last month 0.3 0.5 2.1 0.4 0.9 0.3 0.3 0.2 0.0 -1.5
Mineral and other dietary supplements 2.1 2.8 7.3 1.5 1.8 -2.7 1.4 1.4 1.2 -1.0
Breast cancer (self-reported) 1.1 1.3 3.9 -2.0 0.4 1.1 1.5 -0.3 -0.6 1.1
Asthma (self-reported) 0.4 0.8 2.7 1.6 0.8 0.7 0.6 1.2 0.5 0.2
Osteoporosis (self-reported) 0.3 0.4 1.0 0.6 0.1 0.3 -0.4 -0.3 0.9 1.0
Osteoarthritis (self-reported) 0.5 0.7 1.5 -0.7 -1.2 0.1 -1.0 -1.2 -0.3 0.6
Medication: Aspirin 0.8 1.1 5.6 -2.4 -0.4 0.3 0.3 -1.0 -0.8 0.5
Medication: Gliclazide 0.4 0.4 1.8 -1.4 -0.0 0.6 0.4 -0.8 -0.3 -0.0
Illnesses of father: None of the above (group 1) 0.3 0.3 1.6 0.1 -0.2 -1.3 -0.5 -0.2 -0.4 -0.5
Smoking status: Current 0.3 0.4 2.2 1.5 -0.0 0.5 -0.1 0.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 6.4 -0.1 0.2 2.5 1.0 -1.1 0.3 0.3
Whole body water mass 0.1 0.6 2.6 -0.5 -0.1 -1.6 -0.3 -0.5 -0.8 -0.5
Leg predicted mass (right) 0.1 0.6 2.8 -0.2 -0.1 -1.7 -0.5 -0.7 -0.5 -0.7
Arm fat mass (left) 0.2 0.7 2.5 -1.6 -0.8 0.1 0.6 -0.9 -0.7 -0.4
Number of self-reported non-cancer illnesses 0.6 1.0 3.5 -0.7 0.5 0.9 1.9 1.1 -0.7 -0.4
Average weekly champagne plus white wine intake 0.6 0.8 1.7 0.3 1.2 -0.2 0.8 0.9 1.3 -1.0
Miserableness 0.7 1.1 1.7 -0.2 -1.3 -1.1 -1.3 -1.2 0.8 1.1
Guilty feelings 0.4 0.6 2.1 -1.4 -0.0 0.2 1.2 -0.3 0.6 -0.3
Wears glasses or contact lenses 0.3 0.3 0.8 -0.9 -0.4 0.6 0.2 -0.5 -0.9 -0.1
Ever taken oral contraceptive pill 1.1 1.2 5.2 0.7 -0.4 -2.3 -0.2 0.3 0.5 1.5
Hearing aid user 0.1 0.1 0.4 0.1 0.0 -0.2 0.3 0.0 -0.6 -0.1
Mother’s age at death 1.3 1.6 6.7 -1.5 -1.1 0.2 -0.4 -0.7 -2.6 0.4
Financial situation satisfaction 0.4 0.5 1.4 -0.4 0.5 -0.7 1.2 0.8 0.5 0.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.2 -1.5 -0.1 0.4 0.2 -0.8 -1.1 -1.2
Commuting to job workplace: Public transport 0.3 0.4 1.7 0.4 -0.3 -0.6 -0.4 0.1 -1.3 0.6
Eye problems/disorders: Glaucoma 1.1 1.3 3.1 1.3 1.4 -0.1 1.2 1.0 0.0 -1.8
Medication: Blood pressure 0.2 0.3 1.2 -1.1 -0.0 -0.4 0.0 -0.4 0.2 -0.9
Pain type(s) experienced in last month: Hip pain 0.5 0.7 2.3 -1.5 -0.6 -0.1 1.0 -0.1 -0.9 0.1
Supplements: Fish oil (including cod liver oil) 3.7 4.9 8.3 -1.8 -2.5 2.9 -2.1 -2.3 -2.0 1.6
High cholesterol (Self-reported) 0.7 1.3 5.7 -0.6 0.3 -0.1 1.1 0.9 -0.7 -2.4
Medication: Bendroflumethiazide 0.2 0.3 1.3 -0.5 0.0 0.7 -0.1 -0.1 -0.1 -1.1
Medication: Paracetamol 0.6 0.9 2.1 -0.4 0.1 1.4 1.0 0.1 1.1 1.5
Medication: Lisinopril 1.0 1.2 4.6 -2.1 -0.2 1.3 -0.6 -0.6 -0.5 -1.1
Medication: Atorvastatin 0.5 0.6 1.7 -1.1 0.1 0.5 1.3 0.8 0.2 0.6
Illnesses of father: High blood pressure 1.2 1.5 3.0 -1.5 -1.6 0.4 -1.1 -1.7 -0.3 1.2
Alcohol drinker status: Never 0.7 0.8 3.0 -1.1 0.1 0.1 -0.3 -0.6 -1.0 -1.7
Ever smoked 0.7 1.2 4.7 0.6 0.5 -0.9 0.8 1.3 2.2 0.0
Basal metabolic rate 0.1 0.6 1.7 -0.8 -0.2 -1.3 -0.1 -0.7 -0.9 -0.6
Leg fat percentage (left) 0.3 1.1 3.1 -1.8 -1.3 1.1 0.1 -1.2 -0.6 -0.1
Arm fat-free mass (left) 0.1 0.5 1.1 -0.5 -0.4 -1.1 -0.4 -0.7 -1.0 -0.5
Number of operations (self-reported) 1.2 1.7 3.1 -1.7 -1.5 0.3 -0.4 -1.7 -0.8 1.8
Average weekly beer plus cider intake 1.6 2.3 9.6 1.2 -1.2 -0.3 -3.1 -1.6 -0.2 0.8
Irritability 0.1 0.2 0.3 -0.6 -0.3 0.4 0.6 -0.0 -0.3 0.5
Risk taking 0.8 1.2 4.7 0.3 0.8 -2.2 0.8 0.7 1.0 0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.3 -1.2 -0.2 0.5 1.1 0.3 -0.6 0.2
Fractured/broken bones in last 5 years 1.8 2.3 4.2 2.1 1.7 -0.5 1.5 1.8 1.8 -0.4
Age started oral contraceptive pill 0.7 0.8 2.9 -0.4 -0.5 -1.7 -0.7 -0.6 -1.1 -0.5
Diastolic blood pressure, automated reading 0.3 1.0 3.2 0.2 1.1 0.9 0.3 0.8 1.1 -1.8
Ever depressed for a whole week 0.9 1.2 3.7 -1.1 -0.8 1.9 1.4 -0.6 0.1 0.2
Unable to work because of sickness or disability 0.4 0.5 2.1 -0.3 -1.0 0.4 -0.1 -0.4 0.3 1.4
Commuting to job workplace: Cycle 0.6 0.8 1.6 -0.1 1.1 0.7 0.5 1.3 0.7 -1.1
Myopia 0.3 0.5 2.0 0.1 -0.4 1.0 -0.0 0.2 1.4 0.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 3.0 1.7 1.0 -0.0 -0.0 0.6 1.5 0.9
Cholesterol lowering medication 0.4 0.6 1.3 -0.5 1.2 -0.6 1.0 0.9 -0.0 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.2 -0.2 0.7 1.2 1.5 1.1 0.8 -0.5
Pain experienced in last month 0.3 0.6 2.0 0.6 1.0 0.1 0.1 1.4 -0.6 -0.5
Supplements: Calcium 0.4 0.4 1.6 -0.0 0.2 1.3 0.9 0.5 0.1 0.7
Basal cell carcinoma (self-reported) 0.4 0.5 3.0 0.4 0.2 -1.7 0.1 0.3 0.2 -0.3
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.8 -1.9 -1.5 -0.3 -1.5 -1.8 -0.6 0.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.0 0.3 -0.6 -0.6 -0.4 0.1 -1.0 -0.5
Heart disease (siblings) 0.6 0.8 3.8 -0.5 0.2 1.9 0.2 0.4 -1.0 0.0
Alcohol drinker status: Previous 0.7 0.8 3.0 0.9 -0.8 0.7 -0.1 -0.2 0.7 1.7
Pack years of smoking 0.2 0.3 0.9 -0.7 -0.1 -0.5 0.2 -0.3 -1.0 0.5
Impedance of whole body 0.2 1.1 2.5 1.1 0.9 0.7 1.1 1.6 0.8 -1.0
Leg fat mass (left) 0.3 1.1 3.8 -2.0 -1.0 0.4 0.2 -1.3 -0.9 -0.5
Arm predicted mass (left) 0.1 0.6 1.4 -0.7 -0.5 -0.8 -0.5 -1.0 -1.2 -0.2