Hub : Genes

CHI3L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.4060	0.1210	1.8e-03	0.265	NA	0.154	NA	0.256	1.7e-07	NA	9.4e-05	NA	2.9e-07
2	GTEx	Whole Blood	0.3150	0.0630	2.2e-08	0.229	NA	0.215	NA	0.214	6.1e-21	NA	1.3e-19	NA	1.7e-19
3	METSIM	Adipose	0.0372	0.0165	8.3e-03	0.006	0.013	0.002	0.013	0.005	3.2e-02	3.8e-03	1.5e-01	3.4e-03	4.5e-02
4	NTR	Blood	0.0536	0.0150	5.0e-07	0.042	0.024	0.053	0.047	0.050	2.0e-13	1.8e-08	8.9e-17	7.9e-15	6.9e-16
5	YFS	Blood	0.5650	0.0338	0.0e+00	0.360	0.436	0.478	0.469	0.486	1.4e-124	3.2e-159	1.4e-180	7.5e-176	1.8e-184
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0515	0.0231	6.7e-04	0.012	0.037	0.033	NA	0.026	1.6e-02	4.5e-05	1.1e-04	NA	5.6e-04
7	TCGA	Thyroid Carcinoma	0.1110	0.0370	1.8e-06	0.035	0.048	0.093	NA	0.081	2.1e-04	1.7e-05	2.2e-09	NA	2.4e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	3.2	1.8	0.3	-0.6	0.1	0.8	0.7	0.7
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-0.0	1.2	0.9	1.6	0.7	1.2	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	0.1	-1.1	-0.7	-1.0	-1.1	0.5	1.4
Depression (Nagel 2018)	0.6	0.9	3.3	0.6	-1.3	-0.6	-0.6	-0.6	0.2	1.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.8	-0.2	0.2	-0.8	-0.3	0.5	0.8
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-0.5	-1.0	-0.4	-0.4	-0.9	-0.4	0.8
Schizophrenia (2018)	0.9	1.9	4.1	-1.5	1.2	1.7	2.0	0.2	1.0	-1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	-0.5	1.1	1.1	0.9	0.4	1.3	-0.8
Worry (Nagel 2018)	0.1	0.2	0.6	-0.4	0.1	-0.7	0.8	0.2	-0.1	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	0.3	1.0	-0.3	0.5	0.7	0.6	0.5
Alzheimer’s Disease (in father)	1.6	1.7	4.8	-1.6	-0.6	2.2	-0.2	-1.0	0.7	1.7
Alzheimer’s Disease (including proxy)	0.8	1.1	3.6	-0.2	0.9	1.9	0.7	0.4	1.4	0.7
Crohns Disease (2017)	0.8	1.7	5.1	-1.1	-0.5	1.6	0.9	-1.3	-0.1	2.3
Irritable Bowel Disease (IBD)	0.4	0.9	2.0	0.2	0.7	1.1	0.9	-0.2	1.4	1.3
Ulcerative Colitis (UC)	0.9	1.7	5.9	1.2	1.5	0.5	0.9	1.0	2.4	-0.6
Major Depression (MDD)	0.9	1.1	2.5	0.2	1.2	-0.9	1.6	0.7	0.2	-1.5
Reaction Time	1.2	2.2	4.0	1.9	1.3	2.0	1.6	1.2	1.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.5	-0.8	-0.1	-1.6	-1.0	0.0	0.2	1.2
Breast Cancer	0.2	0.5	1.4	-0.9	0.1	0.9	0.6	-0.0	-1.2	-0.4
Ovarian Cancer	1.7	2.3	7.7	-2.8	-1.1	2.1	1.1	-0.8	-0.9	-0.1
Prostate Cancer	0.8	1.1	2.8	0.5	1.3	-1.1	0.7	0.8	-0.6	-1.7
Age at First Birth	0.1	0.1	0.6	-0.3	-0.3	-0.1	-0.1	-0.0	0.0	0.8
Bipolar Disorder (2011)	0.7	0.7	2.7	1.1	-0.0	-0.1	-0.2	0.1	0.8	1.7
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	-0.8	-0.3	-0.4	-0.3	-1.0	-0.3	-0.3
Coronary Artery Disease (CAD)	1.9	2.2	7.4	0.9	1.8	0.6	1.0	1.6	2.7	-0.4
Crohns Disease (2012)	0.7	1.1	2.6	-0.7	-0.7	1.6	-0.0	-1.2	-0.2	1.6
Mean Putamen Volume	1.5	1.8	3.8	1.4	1.3	1.9	0.5	1.7	0.5	-1.2
Fasting Glucose	1.0	1.2	3.7	1.3	-0.6	0.4	-1.9	-1.0	-0.5	-1.0
HbA1C	1.4	1.6	3.9	2.0	1.3	-1.5	0.3	1.0	0.5	-1.3
HDL Cholesterol	0.3	0.5	1.6	-0.4	-0.8	0.3	-0.7	-0.8	-0.2	1.2
LDL Cholesterol	0.8	1.2	2.2	-0.7	-1.5	0.2	-1.3	-1.3	-1.4	0.5
Lupus	0.3	0.4	1.0	-1.0	0.2	-0.4	0.8	0.3	0.9	-0.6
Neuroticism (2016)	0.4	0.5	2.0	-0.6	0.5	0.7	1.4	0.9	0.1	-0.3
Primary Biliary Cirrhosis	0.4	0.6	2.0	-1.1	-0.4	-1.4	0.5	0.0	-0.8	-0.5
Rheumatoid Arthritis	1.1	1.5	3.6	1.4	-1.2	-1.3	-1.9	-0.9	-0.7	-0.8
Schizophrenia (2014)	0.8	1.8	2.9	-0.5	1.7	1.7	1.7	0.8	1.6	-0.9
Triglycerides	0.4	0.7	2.3	-1.5	-1.1	-0.4	-0.6	-0.7	-0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.7	0.5	-0.7	-1.3	-0.6	-0.2	0.0	0.7
Ulcerative Colitis	0.9	1.3	3.6	1.9	1.1	-0.2	-0.6	0.6	1.8	-0.7
Blood Eosinophil Count	0.5	4.2	19.6	0.4	-1.9	-4.4	-1.8	-1.2	-0.8	-0.5
Blood Platelet Count	0.6	7.2	30.6	1.8	-0.6	-5.5	-3.2	0.3	2.3	0.5
Blood Red Count	0.1	1.4	3.6	-0.2	-1.9	-0.7	-1.4	-1.7	-1.0	0.4
Blood White Count	0.0	0.3	0.9	0.5	-0.8	-1.0	-0.7	-0.3	-0.3	-0.0
Heel T-Score	0.2	1.2	2.2	-0.6	-1.4	-0.8	-1.5	-1.2	-0.3	1.3
BMI	0.1	0.4	1.2	-0.9	-0.8	0.2	-0.1	-1.1	-0.2	-0.5
Height	0.1	2.2	6.6	0.5	0.2	-2.6	-0.8	-0.1	-1.4	-2.5
Waist Hip Ratio (WHR)	0.2	0.9	2.9	-0.2	0.8	-0.4	0.9	0.8	1.1	-1.7
Systolic Blood Pressure	0.3	1.4	4.8	1.0	0.7	1.6	-0.1	1.2	0.2	-2.2
Smoking Status	0.1	0.3	0.9	0.7	-0.4	-0.7	0.2	0.6	0.9	-0.3
Allergy or Eczema	0.4	1.0	2.3	1.3	0.7	0.2	0.3	1.1	1.5	1.0
Cardiovascular Disease	0.3	1.1	4.6	-1.3	-0.1	-0.4	0.5	0.6	-0.8	-2.1
Hypothyroidism (self reported)	0.3	0.8	3.9	-0.7	-0.2	0.1	0.0	-0.4	-2.0	-0.8
Respiratory disease	0.5	1.1	4.9	2.2	0.3	0.5	0.2	1.2	1.0	0.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.1	-1.4	-0.0	1.5	0.8	-0.1	-0.5	0.6
Lung FEV1/FVC ratio	1.3	6.7	33.5	-1.7	-1.1	5.8	0.3	-1.9	-2.0	1.0
Lung FVC	0.1	0.5	2.5	0.5	0.3	0.0	0.4	-0.5	0.1	1.6
Neuroticism	0.2	0.4	2.0	-1.4	-0.3	-0.5	0.2	-0.4	-0.2	0.5
Chronotype (morning person)	0.2	0.4	1.8	0.5	0.1	-1.4	-0.1	0.3	0.1	-0.6
Hair Pigment	0.0	0.2	0.6	0.7	0.2	0.2	0.2	0.8	0.1	-0.4
Tanning	0.0	0.3	1.0	-1.0	0.1	-0.2	0.4	-0.1	0.9	0.2
Hand grip strength (left)	1.0	2.6	6.5	0.3	-1.9	-1.5	-2.5	-1.9	-1.4	0.7
Number of treatments/medications taken	1.2	2.2	6.0	-2.5	-1.2	1.2	1.3	-1.0	-1.7	0.9
Average weekly spirits intake	0.5	0.6	1.1	-0.6	0.7	1.0	0.9	0.6	0.3	-1.0
Sensitivity / hurt feelings	0.2	0.4	1.8	-1.4	-0.6	0.5	-0.3	-0.4	0.4	-0.0
Frequency of depressed mood in last 2 weeks	2.1	3.0	10.4	-0.1	-2.3	0.3	-1.4	-1.8	-0.3	3.2
Hearing difficulty/problems: Yes	0.5	0.7	1.9	-0.9	0.5	0.6	1.4	0.6	-0.1	-1.1
Relative age of first facial hair	0.3	0.6	2.2	1.5	0.4	-0.6	-0.9	0.3	-0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.6	-1.0	0.5	1.1	1.6	1.1	1.0	0.5
Ever used hormone-replacement therapy (HRT)	1.1	1.5	2.7	-0.8	-0.8	0.1	-1.6	-1.6	-1.3	1.5
Ever had hysterectomy (womb removed)	1.5	1.7	5.7	-2.4	-1.5	-0.3	-0.2	-1.7	-0.2	1.0
Systolic blood pressure, automated reading	0.2	0.7	2.7	0.6	0.6	0.4	-1.0	0.3	0.3	-1.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.6	-0.4	-0.9	0.9	-0.5	-0.7	-1.6	0.3
Angina	0.7	1.0	3.6	-1.7	-0.3	-0.1	0.0	-0.4	-1.9	0.0
Medication for hormone replacement therapy	1.0	1.1	2.5	-0.7	-0.9	-0.5	-0.7	-1.4	-1.6	1.1
Vitamin and mineral supplements	1.0	1.4	4.7	0.7	0.5	-2.2	-0.4	0.5	1.9	-0.3
Supplements: Zinc	1.1	1.2	2.0	1.4	1.0	1.4	0.8	1.4	0.9	-0.1
Medication: Co-codamol	0.5	0.6	1.5	-0.9	0.2	1.2	0.5	-0.0	0.8	-0.8
Medication: Metformin	1.2	1.6	4.7	-2.2	-1.0	1.1	1.1	-0.4	-1.7	0.5
Diabetes (father)	0.4	0.5	1.4	0.0	0.7	0.4	0.3	0.1	-1.2	-1.1
Diabetes (mother)	1.0	1.3	2.4	-1.5	-1.1	1.5	0.5	-0.7	-1.2	0.9
Severe depression (siblings)	2.4	2.7	6.6	-2.0	-2.0	0.5	-1.4	-2.6	-1.1	1.0
Pack years adult smoking proportion	0.1	0.1	0.3	-0.1	0.3	-0.5	0.1	0.0	-0.4	0.1
Impedance of leg (right)	0.1	0.7	1.9	0.0	0.5	1.3	0.9	1.4	0.2	-0.1
Leg fat-free mass (left)	0.1	0.6	2.2	-0.6	-0.2	-1.5	-0.4	-0.8	-0.7	-0.8
Trunk fat percentage	0.3	1.2	4.4	-2.1	-1.0	0.9	0.5	-1.0	-0.5	-0.7
Hand grip strength (right)	0.5	1.3	3.6	1.2	-0.4	-1.9	-1.5	-0.4	-0.7	-0.9
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.0	1.2	0.3	0.4	1.2	0.4	-0.5
Current tobacco smoking	0.1	0.2	1.0	1.0	-0.2	0.5	-0.1	0.2	-0.2	0.2
Average weekly fortified wine intake	0.3	0.4	0.9	0.3	-0.5	1.0	0.7	0.7	-0.5	-0.1
Maternal smoking around birth	0.6	0.9	2.7	0.8	0.6	-1.1	0.1	1.0	0.1	-1.6
Fed-up feelings	0.2	0.4	1.3	0.7	-0.6	0.1	-0.8	-0.3	0.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.3	0.8	0.2	0.5	0.4	0.4	0.3	1.1
Relative age voice broke	0.2	0.2	0.6	0.6	0.2	-0.7	0.1	0.8	0.3	0.3
Taking other prescription medications	1.3	2.0	5.7	-2.1	-0.2	2.4	1.8	-0.4	-0.4	0.2
Age when periods started (menarche)	0.4	0.9	2.4	-1.5	-0.5	0.6	-0.8	-1.3	-1.1	-0.3
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	6.0	-1.6	-2.1	-0.7	-1.5	-2.5	-2.0	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	0.7	0.2	-0.5	0.1	0.8	0.6	-0.2
Tinnitus: Yes, but not now, but have in the past	3.9	4.2	7.7	-2.1	-2.8	-0.3	-2.0	-2.6	-2.0	1.6
Qualifications: CSEs or equivalent	0.2	0.2	0.9	-0.4	-0.4	-0.9	-0.1	-0.3	0.4	-0.4
Serious illness, injury or assault to yourself	0.4	0.4	1.1	0.0	-1.1	-0.6	-0.6	-0.8	-0.7	0.0
High blood pressure	0.4	1.0	2.7	-1.6	-0.9	0.2	0.1	-0.6	-1.2	-1.3
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.3	1.8	1.0	-0.3	0.2	1.7	1.4	1.3
Multivitamins +/- minerals	1.1	1.4	3.5	-0.2	-1.0	1.2	-1.3	-0.9	-1.9	1.3
Stomach or abdominal pain in last month	1.0	1.2	2.8	-1.7	-0.8	-1.5	-0.1	-1.0	-1.4	0.3
Supplements: Glucosamine	0.6	0.7	1.5	-0.2	-1.2	1.0	-1.0	-0.9	-0.8	0.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	7.3	2.7	1.6	1.0	0.5	1.5	0.7	-1.1
Medication: Atenolol	0.3	0.4	0.8	-0.7	0.3	-0.9	0.1	-0.3	-0.8	-0.9
Medication: Levothyroxine sodium	0.3	0.5	2.6	-0.2	0.1	0.5	0.5	0.1	-1.6	-0.2
Sitting height	0.1	0.4	1.4	-1.2	0.4	-0.1	0.9	0.0	-0.7	0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	1.5	0.2	-0.8	-0.1	1.0	0.3	-0.2
High blood pressure (mother)	0.7	1.0	2.7	-1.6	-0.4	1.1	1.1	0.0	-0.6	-1.2
Body mass index (BMI)	0.2	1.0	3.0	-1.7	-1.2	0.3	-0.1	-1.5	-0.7	0.0
Impedance of leg (left)	0.1	0.7	1.7	0.4	0.6	1.2	1.0	1.3	0.3	-0.3
Leg predicted mass (left)	0.1	0.6	2.1	-0.6	-0.2	-1.4	-0.4	-0.8	-0.6	-0.8
Trunk fat mass	0.3	1.2	4.1	-2.0	-1.0	0.5	0.4	-1.1	-0.8	-0.8
Waist circumference	0.3	1.0	3.6	-1.1	0.5	0.0	1.4	0.2	0.3	-1.9
Number of incorrect matches in round	1.1	1.9	4.3	-0.5	2.1	1.1	2.0	1.7	0.7	0.1
Past tobacco smoking	0.6	1.1	3.9	-0.4	-0.5	1.1	-1.0	-1.0	-2.0	0.6
Alcohol usually taken with meals	0.5	0.7	1.9	0.8	-0.5	-1.4	-1.3	-0.5	-0.5	-0.3
Nervous feelings	0.2	0.4	1.3	-0.5	-0.8	0.3	-0.3	-1.1	-0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.6	0.0	-1.9	0.4	-0.3	-1.1	-0.8	1.5
Hearing difficulty/problems with background noise	0.1	0.2	1.1	-0.3	-0.0	0.2	1.1	0.4	0.4	0.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.8	-1.1	0.5	0.3	1.3	-0.6	-0.8	0.1
Had menopause	0.1	0.2	0.6	0.1	-0.4	0.1	-0.0	-0.4	-0.8	0.3
Had other major operations	0.1	0.2	0.4	0.3	-0.4	-0.4	-0.2	-0.6	0.0	0.6
Forced vital capacity (FVC)	0.1	0.5	1.3	0.8	0.9	-1.1	0.7	0.2	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.6	0.5	0.4	-0.4	0.3	0.8	0.3	0.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	4.8	-1.4	-0.0	1.6	2.2	-0.2	-0.3	0.1
Qualifications: None of the above	0.1	0.3	1.6	0.4	0.1	-0.3	-1.2	-0.4	0.2	0.2
Financial difficulties in last 2 years	0.8	1.1	2.5	1.6	0.6	-0.5	0.9	1.2	1.5	-0.4
Mouth/teeth dental problems	0.9	1.3	4.7	1.5	-0.5	-0.8	-2.2	-0.8	0.4	0.7
Heart attack	1.2	1.5	3.8	-2.0	-1.4	-0.3	-1.3	-1.6	-0.6	0.2
Allergy	0.7	1.6	5.0	-2.2	-0.8	0.5	0.3	-1.6	-1.2	-1.1
Pain all over the body in last month	1.2	1.3	5.9	-0.7	-0.7	2.4	-0.1	-0.6	0.7	1.1
Diabetes (self-reported)	1.3	2.0	4.8	-2.1	-0.4	2.2	0.5	-0.8	-1.9	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.8	1.9	0.5	1.0	0.5	1.0	0.8	-0.1
Medication: Ramipril	0.8	1.0	2.2	-1.2	-0.9	-1.2	-0.1	-0.9	-1.5	0.1
Medication: Simvastatin	1.1	1.6	5.9	-0.4	0.4	0.8	1.0	0.7	-1.8	-2.4
Fluid intelligence score	0.4	0.8	1.8	-0.8	1.3	-0.3	1.0	1.3	-0.3	-0.1
Illnesses of siblings	0.3	0.5	1.7	-0.5	-0.2	-1.3	-0.4	-0.5	-0.8	0.4
Neuroticism score	0.1	0.2	0.6	-0.8	-0.6	-0.4	0.1	-0.5	0.3	0.4
Weight	0.2	0.8	2.3	-1.5	-0.5	-0.4	0.4	-0.9	-1.0	-1.1
Impedance of arm (right)	0.2	0.7	1.5	0.6	0.5	0.7	1.2	1.2	0.7	-0.6
Arm fat percentage (right)	0.2	0.6	2.2	-1.5	-1.0	0.5	0.7	-0.8	-0.3	-0.2
Trunk fat-free mass	0.1	0.6	2.1	-0.6	-0.2	-1.4	-0.2	-0.5	-1.2	-0.2
Hip circumference	0.1	0.3	0.9	-0.9	-0.2	-0.3	0.2	-0.5	-0.4	-0.6
Time employed in main current job	1.8	2.1	5.3	-1.6	-1.7	0.3	-0.4	-1.7	-2.3	0.9
Alcohol intake versus 10 years previously	0.8	1.3	6.5	-0.5	-0.4	-0.2	0.0	-1.2	-2.5	0.6
Father’s age at death	0.8	1.1	2.4	0.9	0.3	-1.4	1.1	0.3	1.5	0.8
Worrier / anxious feelings	0.7	1.3	3.1	-0.3	-1.4	-1.3	-1.1	-0.9	0.5	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	5.3	-1.4	-0.7	0.4	1.0	-0.2	0.6	2.3
Falls in the last year	0.4	0.5	1.2	-0.7	-1.1	1.0	0.4	-0.3	-0.4	0.6
Hair/balding pattern: Pattern 3	0.8	1.2	3.1	1.4	1.2	-0.4	0.2	1.8	1.1	-0.3
Number of live births	1.6	2.2	4.3	1.1	2.1	1.6	1.4	1.8	1.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	0.4	0.3	0.5	0.4	-0.4	-0.5	0.2
Pulse rate	1.7	2.8	5.6	-0.9	2.2	1.7	2.4	1.6	1.3	-1.2
Happiness	0.3	0.4	0.8	0.7	-0.6	-0.5	-0.5	-0.4	0.3	0.9
Noisy workplace	2.4	3.0	8.1	-2.8	-1.9	0.2	-0.4	-2.4	-1.3	1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.3	0.0	1.1	0.0	1.5	1.2	0.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	0.1	0.2	-0.8	-0.6	-0.6	-0.6	-0.8
Mouth/teeth dental problems: Dentures	2.2	3.6	7.1	-0.7	2.4	0.8	2.7	2.3	0.5	-2.5
Asthma	0.5	1.0	2.8	1.7	0.9	1.0	0.6	1.3	0.8	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.4	-1.0	-0.7	1.1	-0.9	-1.2	0.9	-0.5
Medication: Cholesterol lowering	1.1	1.7	2.7	-1.6	-0.8	1.6	0.8	0.1	-1.6	-1.6
Depression (self-reported)	0.4	0.4	1.4	0.1	0.7	-0.1	1.2	0.6	-0.4	-0.8
Medication: Lansoprazole	1.2	1.3	3.6	-0.2	1.4	1.9	1.1	0.8	1.0	-0.9
Prospective memory result	0.1	0.2	0.7	0.0	-0.2	-0.0	-0.3	-0.3	-0.4	-0.9
Lung cancer (father)	0.7	0.9	1.7	0.8	-0.8	-0.2	-1.3	-0.9	1.3	0.9
Illnesses of mother	0.3	0.4	1.9	0.7	0.3	-0.3	-1.4	-0.3	0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.2	0.1	-0.2	0.7	-0.1	-1.1	-0.5	-0.0
Pulse wave Arterial Stiffness index	0.7	0.8	3.3	-1.8	0.9	0.1	0.9	0.4	-0.5	-0.6
Impedance of arm (left)	0.2	1.0	2.2	1.1	0.9	0.4	1.2	1.5	0.9	-0.8
Arm fat mass (right)	0.2	0.8	2.8	-1.7	-0.8	0.3	0.6	-0.9	-0.6	-0.6
Trunk predicted mass	0.1	0.6	2.4	-0.5	-0.2	-1.6	-0.2	-0.5	-1.2	-0.1
Standing height	0.1	1.4	4.1	0.1	0.9	-1.5	0.9	0.9	-1.0	-2.0
Length of working week for main job	0.4	0.5	2.2	0.5	0.1	-0.2	-0.1	0.2	0.8	1.5
Exposure to tobacco smoke at home	1.6	1.8	4.5	-0.3	-0.9	-0.3	-2.1	-1.7	-2.1	-0.3
Breastfed as a baby	0.5	0.6	1.2	1.1	0.1	-1.0	-0.8	0.5	1.0	0.4
Tense / ‘highly strung’	0.1	0.2	0.9	-0.3	-0.1	0.3	0.9	0.3	-0.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	5.5	2.0	-0.3	0.2	0.3	0.5	2.4	1.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.2	-0.9	0.3	-0.7	-0.3	0.1	0.9
Birth weight of first child	1.4	2.6	10.6	1.1	-1.3	-1.6	-3.3	-0.9	-0.7	0.7
Peak expiratory flow (PEF)	0.2	0.4	2.2	0.3	0.1	1.5	-0.7	-0.3	0.0	-0.3
Pulse wave reflection index	0.1	0.2	0.6	-0.2	0.7	-0.0	0.6	0.4	-0.0	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.9	-0.9	-0.4	0.4	0.8	-0.3	-0.5	1.0
Loud music exposure frequency	0.5	0.6	2.0	0.6	0.2	-0.4	1.1	0.6	-0.1	1.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.8	-0.5	0.8	-0.3	1.3	0.6	0.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.9	-0.8	-1.4	-0.0	-0.4	-1.3	-0.9	1.3
Blood clot in the leg (DVT)	0.4	0.5	1.2	0.2	-0.9	-1.0	-0.8	-0.1	-1.1	-0.4
Medication: Paracetamol	0.8	1.4	4.4	-0.6	0.3	1.1	1.2	0.0	1.5	2.1
Headache pain in last month	0.2	0.4	1.0	0.4	0.0	-1.0	0.1	-0.4	0.9	0.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.6	2.4	1.1	-0.6	-0.8	0.3	1.7	1.2
Glaucoma (self-reported)	1.8	2.2	4.8	2.2	1.9	0.1	1.2	1.5	1.1	-1.3
Gout (self-reported)	0.5	0.7	1.9	-1.4	-0.4	0.6	-0.4	-1.2	-0.5	-0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	-0.2	0.1	0.8	0.6	0.1	-1.2	-0.2
Medication: Amlodipine	1.1	1.5	2.9	-1.3	-1.6	0.7	-0.3	-1.7	-1.6	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.8	1.4	0.1	-0.0	-0.0	0.5	0.6	1.3
Birth weight	0.2	0.5	2.1	1.0	-0.1	0.0	-0.1	0.5	1.4	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	-0.9	0.1	0.9	-0.0	-1.2	0.1	-0.1
High blood pressure (siblings)	0.1	0.2	0.4	0.0	0.0	0.6	0.4	0.1	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.5	0.7	0.6	-0.7	0.3	-0.2	0.1	-0.4
Body fat percentage	0.3	1.0	3.8	-1.9	-1.1	0.8	0.5	-1.0	-0.5	-0.4
Leg fat percentage (right)	0.4	1.5	5.2	-2.3	-1.4	1.1	0.2	-1.2	-0.7	0.1
Arm fat-free mass (right)	0.1	0.7	2.4	-0.4	-0.1	-1.5	-0.6	-0.6	-1.0	-0.7
Exposure to tobacco smoke outside home	0.7	0.9	2.8	1.0	-0.3	-1.7	-0.8	-0.4	-1.1	-0.6
Comparative body size at age 10	0.2	0.5	2.0	-0.3	-0.2	-1.4	0.9	0.3	-0.5	0.1
Number of full brothers	0.2	0.3	0.8	-0.5	0.5	0.9	-0.1	-0.0	0.1	-0.7
Worry too long after embarrassment	1.1	1.9	5.0	0.1	-2.2	0.9	-2.0	-1.6	-1.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.6	0.8	-0.3	0.6	0.0	-0.1	1.9	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.8	-0.5	0.7	0.4	0.2	-0.8	-0.0
Number of children fathered	0.8	1.0	2.0	-1.4	-1.1	0.1	-0.8	-1.0	-1.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	-1.1	-1.0	-0.8	-0.6	-0.7	-1.4	-0.1
Age at first live birth	0.6	1.1	3.1	0.7	1.2	0.7	1.2	1.1	-0.1	-1.8
Pulse wave peak to peak time	0.6	0.7	2.9	1.7	-0.9	-0.4	-0.9	-0.4	0.3	0.3
Health satisfaction	0.3	0.4	1.3	-1.1	0.2	0.8	0.2	-0.3	0.8	0.2
Shortness of breath walking on level ground	0.4	0.4	1.2	-1.1	-1.1	-0.3	0.2	-0.6	-0.3	0.3
Qualifications: College or University degree	0.3	1.0	3.9	0.2	0.4	0.4	0.9	1.0	-1.1	2.0
Eye problems/disorders: None of the above	0.8	0.9	2.2	1.0	0.5	-1.3	0.2	1.2	1.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	0.3	-0.9	-0.6	-1.0	-1.1	-0.5	1.4
Emphysema/chronic bronchitis	0.3	0.4	1.0	-0.2	-0.8	-0.0	-0.6	-0.4	0.4	1.0
Medication for pain relief, constipation, heartburn	1.3	2.2	6.1	2.5	0.2	-1.5	-1.5	0.6	-1.5	-1.3
Neck or shoulder pain in last month	0.2	0.3	0.5	0.4	-0.5	0.6	-0.7	-0.4	0.5	-0.6
Medication: Blood pressure	1.5	2.7	8.0	-2.8	-2.0	0.2	-0.2	-1.6	-2.1	0.3
Angina (self-reported)	0.7	0.9	3.5	-1.6	0.1	0.1	0.3	-0.1	-1.9	-0.1
Migraine (self-reported)	1.6	2.0	6.2	-2.5	-0.0	1.5	1.6	-0.6	-1.6	0.5
Medication: Ibuprofen	0.5	0.6	1.4	-0.4	-0.7	0.8	-0.7	-0.7	1.2	-0.6
Medication: Allopurinol	0.2	0.2	0.4	-0.5	-0.5	0.1	-0.5	-0.6	-0.6	-0.4
Medication: Omeprazole	0.4	0.4	1.3	0.6	0.2	1.1	1.0	0.6	0.2	0.2
Medication: Seretide 50 evohaler	1.1	1.2	5.8	1.0	-0.7	-0.2	-0.8	-0.4	0.6	2.4
Mean time to correctly identify matches	1.2	2.3	5.8	1.4	1.1	2.4	1.5	1.1	1.8	-0.9
Heart disease (mother)	0.3	0.3	1.6	0.5	-0.2	1.3	-0.2	0.1	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.0	0.0	0.6	0.3	-0.1	0.1	1.4	0.5
Whole body fat mass	0.3	1.1	4.5	-2.1	-0.9	0.4	0.5	-1.0	-0.8	-0.6
Leg fat mass (right)	0.4	1.5	5.4	-2.3	-1.2	0.4	0.2	-1.4	-1.1	-0.3
Arm predicted mass (right)	0.1	0.4	1.5	-0.4	0.2	-1.2	-0.2	-0.4	-0.7	-0.8
Pulse rate, automated reading	1.9	6.2	10.0	-0.4	2.7	3.2	3.0	2.5	1.9	-2.6
Alcohol intake frequency.	0.4	1.0	2.3	-0.2	-1.1	-0.0	-1.1	-1.5	-1.5	0.3
Comparative height size at age 10	0.2	1.0	2.0	-1.1	1.1	1.4	0.8	0.3	-1.0	-0.9
Number of full sisters	0.1	0.2	0.7	-0.0	-0.3	0.3	0.8	0.2	0.5	0.3
Suffer from ‘nerves’	0.2	0.3	1.1	-0.1	-1.1	0.1	0.1	-0.6	-0.8	0.5
Overall health rating	0.5	1.0	3.2	-1.4	-0.7	1.8	0.4	-0.2	1.0	0.5
Chest pain or discomfort	1.1	1.6	3.0	-1.7	-1.7	1.3	-0.3	-1.1	-0.2	1.6
Had major operations	1.8	2.2	5.3	-2.3	-1.5	1.3	0.1	-1.2	-1.1	1.8
Age at last live birth	0.9	1.2	2.4	1.4	1.1	0.7	1.5	1.4	-0.5	-0.6
Family relationship satisfaction	1.8	2.2	5.5	-0.8	-1.0	2.4	-0.5	-1.5	-1.6	1.7
Leg pain on walking	0.2	0.2	0.7	-0.3	-0.4	-0.8	-0.1	0.1	-0.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	-0.3	-0.4	-1.0	0.4	0.0	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	-0.6	-1.1	-0.3	-0.4	-1.1	-0.9	1.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.0	0.5	-0.6	0.6	0.5	-0.3	0.4
Medication: Aspirin	1.2	1.6	8.0	-2.8	-0.5	0.2	0.4	-1.2	-1.0	0.6
Supplements: Vitamin C	1.8	2.2	7.5	-1.2	-1.1	2.7	0.8	-1.0	-1.8	-0.3
Knee pain experienced in last month	1.9	2.9	6.8	-2.0	-2.2	-0.4	-1.6	-2.6	-1.3	0.9
Hypertension (Self-reported)	0.5	1.4	4.3	-2.1	-0.6	0.5	0.2	-0.6	-1.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	-0.4	0.4	0.9	1.2	0.4	1.2	-1.1
Illnesses of father: Heart disease	0.6	0.9	4.2	-0.1	0.4	2.0	0.9	0.2	-0.8	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.5	-0.4	-1.2	1.1	-0.3	-0.3	-0.8	0.2
Smoking status: Previous	1.3	2.0	5.7	0.2	1.4	-0.5	1.7	1.3	2.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.5	0.2	-0.2	0.3	0.1	-0.4	-0.8
Whole body fat-free mass	0.1	0.6	2.3	-0.6	-0.2	-1.5	-0.4	-0.7	-0.9	-0.4
Leg fat-free mass (right)	0.1	0.7	2.9	-0.3	-0.2	-1.7	-0.6	-0.9	-0.5	-0.6
Arm fat percentage (left)	0.1	0.5	1.6	-1.3	-0.8	0.2	0.7	-0.7	-0.2	-0.2
Average weekly red wine intake	0.3	0.4	1.3	1.0	0.2	1.1	-0.3	0.3	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.4	-0.5	1.2	1.2	1.1	0.7	1.0	-1.0
Mood swings	0.5	0.8	1.9	1.3	-0.1	-1.0	-0.4	0.3	1.4	0.9
Loneliness, isolation	1.0	1.4	2.8	-1.1	-1.6	0.4	-0.8	-1.7	-0.7	1.4
Long-standing illness, disability or infirmity	0.9	1.3	3.1	-1.2	-0.4	1.7	1.2	0.1	0.2	1.8
Ever had bowel cancer screening	1.3	1.5	3.0	-1.6	0.0	1.4	1.4	-0.3	1.0	1.7
Diabetes diagnosed by doctor	1.0	1.6	5.2	-1.7	-0.1	2.3	0.7	-0.4	-1.5	0.7
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	5.0	1.7	1.2	-1.1	1.5	2.2	2.1	-0.3
Friendships satisfaction	0.5	0.6	1.3	1.1	0.4	1.1	-0.2	0.3	-1.1	0.6
Qualifications: nursing, teaching	0.5	0.8	2.6	0.9	-0.4	-1.6	-0.1	0.1	-0.6	1.2
Commuting to job workplace: Walk	1.6	1.7	3.7	0.9	1.6	0.9	1.0	1.9	0.7	-1.6
Eye problems/disorders: Cataract	2.4	2.8	6.2	-1.2	-2.0	1.1	-2.0	-2.5	-1.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.5	-2.1	-0.3	0.2	1.7	0.2	-0.3	-0.2
Medication for cholesterol	0.1	0.1	0.4	0.3	-0.1	0.7	0.4	0.2	0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.2	-0.9	0.7	0.2	-0.8	-0.8	0.5
Back pain experienced in last month	0.3	0.5	2.1	0.4	0.9	0.3	0.3	0.2	0.0	-1.5
Mineral and other dietary supplements	2.1	2.8	7.3	1.5	1.8	-2.7	1.4	1.4	1.2	-1.0
Breast cancer (self-reported)	1.1	1.3	3.9	-2.0	0.4	1.1	1.5	-0.3	-0.6	1.1
Asthma (self-reported)	0.4	0.8	2.7	1.6	0.8	0.7	0.6	1.2	0.5	0.2
Osteoporosis (self-reported)	0.3	0.4	1.0	0.6	0.1	0.3	-0.4	-0.3	0.9	1.0
Osteoarthritis (self-reported)	0.5	0.7	1.5	-0.7	-1.2	0.1	-1.0	-1.2	-0.3	0.6
Medication: Aspirin	0.8	1.1	5.6	-2.4	-0.4	0.3	0.3	-1.0	-0.8	0.5
Medication: Gliclazide	0.4	0.4	1.8	-1.4	-0.0	0.6	0.4	-0.8	-0.3	-0.0
Illnesses of father: None of the above (group 1)	0.3	0.3	1.6	0.1	-0.2	-1.3	-0.5	-0.2	-0.4	-0.5
Smoking status: Current	0.3	0.4	2.2	1.5	-0.0	0.5	-0.1	0.5	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	6.4	-0.1	0.2	2.5	1.0	-1.1	0.3	0.3
Whole body water mass	0.1	0.6	2.6	-0.5	-0.1	-1.6	-0.3	-0.5	-0.8	-0.5
Leg predicted mass (right)	0.1	0.6	2.8	-0.2	-0.1	-1.7	-0.5	-0.7	-0.5	-0.7
Arm fat mass (left)	0.2	0.7	2.5	-1.6	-0.8	0.1	0.6	-0.9	-0.7	-0.4
Number of self-reported non-cancer illnesses	0.6	1.0	3.5	-0.7	0.5	0.9	1.9	1.1	-0.7	-0.4
Average weekly champagne plus white wine intake	0.6	0.8	1.7	0.3	1.2	-0.2	0.8	0.9	1.3	-1.0
Miserableness	0.7	1.1	1.7	-0.2	-1.3	-1.1	-1.3	-1.2	0.8	1.1
Guilty feelings	0.4	0.6	2.1	-1.4	-0.0	0.2	1.2	-0.3	0.6	-0.3
Wears glasses or contact lenses	0.3	0.3	0.8	-0.9	-0.4	0.6	0.2	-0.5	-0.9	-0.1
Ever taken oral contraceptive pill	1.1	1.2	5.2	0.7	-0.4	-2.3	-0.2	0.3	0.5	1.5
Hearing aid user	0.1	0.1	0.4	0.1	0.0	-0.2	0.3	0.0	-0.6	-0.1
Mother’s age at death	1.3	1.6	6.7	-1.5	-1.1	0.2	-0.4	-0.7	-2.6	0.4
Financial situation satisfaction	0.4	0.5	1.4	-0.4	0.5	-0.7	1.2	0.8	0.5	0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	-1.5	-0.1	0.4	0.2	-0.8	-1.1	-1.2
Commuting to job workplace: Public transport	0.3	0.4	1.7	0.4	-0.3	-0.6	-0.4	0.1	-1.3	0.6
Eye problems/disorders: Glaucoma	1.1	1.3	3.1	1.3	1.4	-0.1	1.2	1.0	0.0	-1.8
Medication: Blood pressure	0.2	0.3	1.2	-1.1	-0.0	-0.4	0.0	-0.4	0.2	-0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.3	-1.5	-0.6	-0.1	1.0	-0.1	-0.9	0.1
Supplements: Fish oil (including cod liver oil)	3.7	4.9	8.3	-1.8	-2.5	2.9	-2.1	-2.3	-2.0	1.6
High cholesterol (Self-reported)	0.7	1.3	5.7	-0.6	0.3	-0.1	1.1	0.9	-0.7	-2.4
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.5	0.0	0.7	-0.1	-0.1	-0.1	-1.1
Medication: Paracetamol	0.6	0.9	2.1	-0.4	0.1	1.4	1.0	0.1	1.1	1.5
Medication: Lisinopril	1.0	1.2	4.6	-2.1	-0.2	1.3	-0.6	-0.6	-0.5	-1.1
Medication: Atorvastatin	0.5	0.6	1.7	-1.1	0.1	0.5	1.3	0.8	0.2	0.6
Illnesses of father: High blood pressure	1.2	1.5	3.0	-1.5	-1.6	0.4	-1.1	-1.7	-0.3	1.2
Alcohol drinker status: Never	0.7	0.8	3.0	-1.1	0.1	0.1	-0.3	-0.6	-1.0	-1.7
Ever smoked	0.7	1.2	4.7	0.6	0.5	-0.9	0.8	1.3	2.2	0.0
Basal metabolic rate	0.1	0.6	1.7	-0.8	-0.2	-1.3	-0.1	-0.7	-0.9	-0.6
Leg fat percentage (left)	0.3	1.1	3.1	-1.8	-1.3	1.1	0.1	-1.2	-0.6	-0.1
Arm fat-free mass (left)	0.1	0.5	1.1	-0.5	-0.4	-1.1	-0.4	-0.7	-1.0	-0.5
Number of operations (self-reported)	1.2	1.7	3.1	-1.7	-1.5	0.3	-0.4	-1.7	-0.8	1.8
Average weekly beer plus cider intake	1.6	2.3	9.6	1.2	-1.2	-0.3	-3.1	-1.6	-0.2	0.8
Irritability	0.1	0.2	0.3	-0.6	-0.3	0.4	0.6	-0.0	-0.3	0.5
Risk taking	0.8	1.2	4.7	0.3	0.8	-2.2	0.8	0.7	1.0	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	-1.2	-0.2	0.5	1.1	0.3	-0.6	0.2
Fractured/broken bones in last 5 years	1.8	2.3	4.2	2.1	1.7	-0.5	1.5	1.8	1.8	-0.4
Age started oral contraceptive pill	0.7	0.8	2.9	-0.4	-0.5	-1.7	-0.7	-0.6	-1.1	-0.5
Diastolic blood pressure, automated reading	0.3	1.0	3.2	0.2	1.1	0.9	0.3	0.8	1.1	-1.8
Ever depressed for a whole week	0.9	1.2	3.7	-1.1	-0.8	1.9	1.4	-0.6	0.1	0.2
Unable to work because of sickness or disability	0.4	0.5	2.1	-0.3	-1.0	0.4	-0.1	-0.4	0.3	1.4
Commuting to job workplace: Cycle	0.6	0.8	1.6	-0.1	1.1	0.7	0.5	1.3	0.7	-1.1
Myopia	0.3	0.5	2.0	0.1	-0.4	1.0	-0.0	0.2	1.4	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.0	1.7	1.0	-0.0	-0.0	0.6	1.5	0.9
Cholesterol lowering medication	0.4	0.6	1.3	-0.5	1.2	-0.6	1.0	0.9	-0.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	-0.2	0.7	1.2	1.5	1.1	0.8	-0.5
Pain experienced in last month	0.3	0.6	2.0	0.6	1.0	0.1	0.1	1.4	-0.6	-0.5
Supplements: Calcium	0.4	0.4	1.6	-0.0	0.2	1.3	0.9	0.5	0.1	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	3.0	0.4	0.2	-1.7	0.1	0.3	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.8	-1.9	-1.5	-0.3	-1.5	-1.8	-0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	0.3	-0.6	-0.6	-0.4	0.1	-1.0	-0.5
Heart disease (siblings)	0.6	0.8	3.8	-0.5	0.2	1.9	0.2	0.4	-1.0	0.0
Alcohol drinker status: Previous	0.7	0.8	3.0	0.9	-0.8	0.7	-0.1	-0.2	0.7	1.7
Pack years of smoking	0.2	0.3	0.9	-0.7	-0.1	-0.5	0.2	-0.3	-1.0	0.5
Impedance of whole body	0.2	1.1	2.5	1.1	0.9	0.7	1.1	1.6	0.8	-1.0
Leg fat mass (left)	0.3	1.1	3.8	-2.0	-1.0	0.4	0.2	-1.3	-0.9	-0.5
Arm predicted mass (left)	0.1	0.6	1.4	-0.7	-0.5	-0.8	-0.5	-1.0	-1.2	-0.2