Hub : Genes

ATE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.081	0.0280	0.00160	0.015	0.021	0.023	0.021	0.014	0.0048	0.00120	7.5e-04	0.0012	6.8e-03
2	GTEx	Adipose Subcutaneous	0.185	0.0510	0.00025	0.019	NA	0.060	NA	0.056	0.0100	NA	1.1e-05	NA	2.1e-05
3	GTEx	Artery Tibial	0.185	0.0519	0.00015	0.015	NA	0.088	NA	0.077	0.0220	NA	2.3e-07	NA	1.2e-06
4	GTEx	Esophagus Mucosa	0.171	0.0550	0.00260	0.022	NA	0.032	NA	0.021	0.0130	NA	3.2e-03	NA	1.3e-02
5	TCGA	Thyroid Carcinoma	0.087	0.0390	0.00270	0.007	0.030	0.031	NA	0.012	0.0620	0.00059	5.3e-04	NA	2.0e-02
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.240	0.1140	0.00940	-0.009	0.030	0.002	NA	-0.009	0.7100	0.05000	2.8e-01	NA	7.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.1	2.5	0.6	-1.1	-0.6	-1.6	-1.5	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.0	-1.0	0.7	0.7	-1.0	-1.0	0.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	0.2	0.9	0.1	0.5	-1.5	-1.2
Depression (Nagel 2018)	0.8	1.2	3.3	0.4	0.3	1.8	-0.3	-1.8	0.2
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.9	1.4	0.5	-0.2	-1.6	-2.4	-2.3
Neuroticism (Nagel 2018)	0.3	0.7	1.3	-0.2	1.1	0.4	0.6	-1.1	-1.2
Schizophrenia (2018)	0.7	1.5	3.5	-1.8	1.9	1.3	-0.0	-0.1	0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	2.2	0.1	1.5	0.3	-0.0	0.3	1.1
Worry (Nagel 2018)	0.6	1.3	2.7	-1.1	1.6	1.0	0.3	-0.6	-1.6
Alzheimer’s Disease (in mother)	1.5	1.7	4.0	-0.4	1.3	0.5	2.0	1.9	0.8
Alzheimer’s Disease (in father)	0.9	1.0	4.2	-0.9	-0.2	-0.4	0.9	2.0	0.1
Alzheimer’s Disease (including proxy)	1.4	2.0	5.2	-0.9	1.4	0.7	1.8	2.3	0.4
Crohns Disease (2017)	0.6	1.3	4.1	-1.4	0.6	0.6	1.0	-0.4	-2.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.3	-0.7	-0.4	0.3	0.6	-0.6
Ulcerative Colitis (UC)	0.4	0.7	1.9	0.7	-1.4	-0.9	-0.3	1.0	0.6
Major Depression (MDD)	0.8	1.0	2.5	0.7	0.1	0.6	1.6	1.3	1.0
Reaction Time	0.8	1.6	5.4	-0.2	0.3	1.0	1.1	2.3	1.3
Verbal and Numeric Reasoning (VNR)	1.0	2.3	6.4	0.4	0.9	-0.8	-1.5	-1.9	-2.5
Breast Cancer	6.4	15.3	47.0	-0.9	3.5	6.9	1.8	0.2	5.3
Ovarian Cancer	1.4	1.8	4.6	-1.9	-0.8	-2.1	-0.3	-0.8	-1.2
Prostate Cancer	1.6	2.3	4.6	-0.1	0.5	2.1	2.0	2.1	0.6
Age at First Birth	2.0	2.9	6.7	0.8	-1.8	-2.6	-1.5	-1.5	-1.4
Bipolar Disorder (2011)	0.3	0.2	0.5	0.7	-0.5	0.2	-0.4	-0.6	0.3
Body Mass Index (BMI) (2010)	0.7	0.9	3.2	-0.7	0.1	1.8	1.3	0.1	0.4
Coronary Artery Disease (CAD)	1.4	1.7	5.4	-0.3	1.2	0.9	1.6	-0.1	-2.3
Crohns Disease (2012)	0.5	0.8	3.1	-0.4	-0.3	-0.1	0.4	-1.0	-1.8
Mean Putamen Volume	0.3	0.4	0.6	0.6	-0.8	-0.4	-0.7	-0.8	-0.0
Fasting Glucose	1.9	2.3	6.6	1.2	1.6	1.5	0.1	1.0	2.6
HbA1C	0.6	0.7	1.5	1.2	-1.0	-0.7	-0.9	-0.3	-0.3
HDL Cholesterol	0.4	0.7	3.6	0.0	1.9	-0.2	-0.2	-0.4	-0.7
LDL Cholesterol	0.5	0.9	2.7	-0.2	1.4	1.6	0.4	0.4	0.3
Lupus	0.8	1.2	2.2	1.0	-0.7	-1.5	-0.9	-1.0	1.2
Neuroticism (2016)	0.5	0.8	1.4	1.1	-0.9	-0.5	-1.2	-0.4	0.9
Primary Biliary Cirrhosis	0.6	0.8	2.0	0.5	0.6	-1.4	-0.2	1.4	0.6
Rheumatoid Arthritis	0.9	1.2	3.5	1.1	0.1	-1.9	-1.2	-1.2	0.1
Schizophrenia (2014)	0.8	1.7	5.1	-1.5	2.3	1.3	-0.2	-0.7	0.4
Triglycerides	0.1	0.2	0.6	0.4	-0.6	0.1	-0.4	-0.2	0.8
Type 2 Diabetes (T2D) (2012)	1.4	1.7	4.8	0.8	0.6	0.6	1.7	2.2	0.9
Ulcerative Colitis	0.8	1.1	3.5	1.0	-1.9	-1.2	-0.2	0.3	0.7
Blood Eosinophil Count	0.1	0.8	1.6	0.6	1.0	1.3	0.4	-0.7	0.9
Blood Platelet Count	0.2	2.3	4.6	-0.3	-2.0	-0.6	2.1	2.1	-0.0
Blood Red Count	0.1	1.2	3.8	-0.4	0.7	0.8	-1.3	-1.9	0.7
Blood White Count	0.2	1.4	5.7	0.3	0.0	0.4	1.6	2.4	-0.1
Heel T-Score	3.8	30.3	94.1	-4.6	5.4	9.7	-1.2	-1.1	5.9
BMI	0.2	1.0	3.1	-0.5	0.2	1.7	0.3	-1.8	-0.3
Height	0.6	12.3	18.4	4.3	-4.0	-3.7	-1.6	-4.0	-2.7
Waist Hip Ratio (WHR)	1.3	5.7	15.0	0.4	-2.4	0.7	3.2	3.9	1.6
Systolic Blood Pressure	0.5	2.6	5.3	-1.9	0.7	1.9	2.3	1.3	-1.0
Smoking Status	1.0	2.4	9.7	0.3	-0.2	1.0	3.1	1.6	0.9
Allergy or Eczema	1.2	3.1	6.3	2.5	-1.5	-0.6	-1.5	1.5	2.3
Cardiovascular Disease	1.1	3.5	7.0	-0.5	2.2	2.6	2.5	1.5	0.9
Hypothyroidism (self reported)	0.4	0.9	2.5	-1.6	1.5	0.6	-0.5	-0.4	-0.6
Respiratory disease	0.6	1.3	2.9	0.2	1.7	0.9	-1.6	-0.4	1.2
Type 2 Diabetes (T2D) (2018)	0.8	1.6	5.5	-0.6	-1.3	0.1	0.4	2.4	1.3
Lung FEV1/FVC ratio	1.2	6.3	26.2	-2.1	0.2	-0.4	1.9	-1.8	-5.1
Lung FVC	0.5	2.5	12.7	-3.6	-0.2	-0.1	0.8	1.3	0.2
Neuroticism	0.6	1.4	2.9	-1.4	1.7	1.1	0.5	-1.1	-1.1
Chronotype (morning person)	4.0	9.3	25.0	5.0	-1.7	-3.4	-3.3	-2.3	-0.6
Hair Pigment	0.0	0.4	1.2	-1.1	0.2	-0.2	0.5	0.7	-0.4
Tanning	0.1	1.3	2.5	-1.3	-1.5	-1.1	0.6	-0.0	-1.6
Hand grip strength (left)	0.8	2.1	7.7	-0.9	-0.5	-0.8	0.8	-1.5	-2.8
Number of treatments/medications taken	0.9	1.6	3.3	-1.3	0.7	1.8	1.0	1.1	1.5
Average weekly spirits intake	1.4	1.7	6.2	-0.4	1.3	2.5	1.3	0.4	-0.5
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.0	-0.1	-0.7	1.1	0.3	-0.5
Frequency of depressed mood in last 2 weeks	0.9	1.2	5.8	-0.3	0.7	2.4	0.7	-0.5	0.3
Hearing difficulty/problems: Yes	0.3	0.4	0.7	0.2	0.6	-0.4	-0.9	0.5	0.8
Relative age of first facial hair	2.3	4.8	16.0	2.0	-0.8	-1.4	-4.0	-1.3	2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.8	-1.2	-0.2	-0.2	1.3	-0.2	0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.3	4.3	0.3	-0.9	0.3	-1.4	-2.1	0.9
Ever had hysterectomy (womb removed)	0.9	1.0	4.9	-2.2	0.5	0.4	0.7	0.1	0.6
Systolic blood pressure, automated reading	0.4	1.2	3.3	-1.8	-0.1	1.1	1.3	-0.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.4	0.6	0.7	0.2	0.0	0.6
Angina	0.3	0.4	0.8	-0.3	-0.4	-0.9	0.2	-0.4	-0.9
Medication for hormone replacement therapy	0.1	0.2	0.3	-0.3	-0.3	-0.6	-0.4	0.2	-0.5
Vitamin and mineral supplements	0.3	0.4	0.7	-0.9	-0.4	0.0	0.8	0.6	-0.6
Supplements: Zinc	0.4	0.5	1.2	-1.1	0.4	1.1	0.3	0.3	-0.3
Medication: Co-codamol	0.6	0.6	1.5	-1.1	-0.1	-0.5	-1.2	0.9	0.1
Medication: Metformin	2.7	3.8	12.2	-0.3	-1.1	0.7	1.7	3.5	2.4
Diabetes (father)	0.3	0.4	0.9	-0.3	-0.4	0.1	-0.6	-0.8	1.0
Diabetes (mother)	1.8	2.3	7.3	-0.5	0.8	0.3	2.3	2.7	0.5
Severe depression (siblings)	2.0	2.3	8.8	1.4	-0.4	-0.6	-3.0	-0.1	1.4
Pack years adult smoking proportion	0.4	0.5	1.3	-0.2	-1.0	0.2	-1.2	-0.8	-0.2
Impedance of leg (right)	0.2	1.0	2.7	1.6	-0.7	0.7	-0.3	0.4	1.4
Leg fat-free mass (left)	0.4	2.0	4.3	1.5	-1.0	-1.6	0.0	-2.1	-1.5
Trunk fat percentage	0.3	1.2	2.0	1.4	-1.1	1.1	1.0	-1.2	0.6
Hand grip strength (right)	0.9	2.5	9.6	0.0	-0.8	-1.1	0.9	-1.7	-3.1
Townsend deprivation index at recruitment	0.5	0.8	1.6	0.4	-1.3	-1.0	-1.1	0.6	0.4
Current tobacco smoking	0.1	0.2	0.8	-0.0	0.2	0.9	0.3	-0.1	0.3
Average weekly fortified wine intake	1.3	1.5	3.8	-1.4	-0.2	1.4	-0.4	1.2	2.0
Maternal smoking around birth	1.1	1.6	3.5	0.2	-1.1	1.6	0.5	1.5	1.9
Fed-up feelings	0.4	0.7	1.4	-1.0	0.3	-0.0	1.2	-0.7	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.1	-0.1	-0.2	1.5	0.6	-0.7	-0.3
Relative age voice broke	1.7	2.5	8.1	1.5	-0.9	-1.1	-2.8	-0.7	1.5
Taking other prescription medications	1.5	2.4	6.2	-2.5	0.7	1.5	1.4	1.7	0.7
Age when periods started (menarche)	3.5	8.5	22.7	4.8	-2.8	-3.1	-2.4	-2.0	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.6	0.6	0.1	0.8	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	3.4	7.7	20.3	-2.7	3.9	4.5	1.1	0.2	1.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-1.2	0.6	0.7	0.0	0.7	-0.5
Qualifications: CSEs or equivalent	0.9	1.2	2.4	0.2	-1.5	-1.2	-1.0	1.3	0.9
Serious illness, injury or assault to yourself	1.2	1.4	4.5	0.4	0.8	-1.2	-1.1	-2.1	-0.8
High blood pressure	0.8	2.3	4.6	0.1	1.7	2.1	2.0	1.2	1.2
Hayfever, allergic rhinitis or eczema	2.3	5.0	9.7	3.1	-1.3	-1.2	-2.9	1.2	2.6
Multivitamins +/- minerals	0.2	0.2	0.8	0.5	-0.2	-0.9	0.1	0.1	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.2	-0.5	0.7	0.9	1.1	-0.1	-0.3
Supplements: Glucosamine	0.3	0.4	1.2	0.1	-1.0	-0.1	-0.6	-0.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	0.9	0.8	0.8	-0.3	1.0	0.5
Medication: Atenolol	0.7	0.9	2.4	0.1	-0.3	1.6	-0.2	-0.4	1.6
Medication: Levothyroxine sodium	0.3	0.5	1.7	-0.1	1.1	1.3	0.1	-0.4	0.0
Sitting height	0.3	2.1	6.7	1.0	0.2	-0.8	1.2	-1.7	-2.6
Chronic bronchitis/emphysema (father)	0.8	0.9	2.6	1.6	-0.8	1.2	0.5	-0.1	0.6
High blood pressure (mother)	0.8	1.2	2.2	0.0	1.4	1.4	-0.9	0.5	1.5
Body mass index (BMI)	0.1	0.5	1.3	-0.4	0.3	1.1	1.1	-0.5	-0.1
Impedance of leg (left)	0.2	0.9	2.0	1.3	-1.0	0.6	-0.5	0.2	1.4
Leg predicted mass (left)	0.4	1.9	3.8	1.4	-1.1	-1.5	0.2	-2.0	-1.5
Trunk fat mass	0.3	1.4	3.0	1.7	-1.2	0.4	0.9	-1.7	-0.1
Waist circumference	0.3	1.0	1.7	1.3	-0.8	1.1	1.1	-0.2	1.1
Number of incorrect matches in round	0.1	0.2	1.0	-1.0	-0.1	-0.0	-0.5	-0.1	0.1
Past tobacco smoking	1.1	2.1	8.7	-0.1	0.9	-0.6	-2.9	-1.5	-0.4
Alcohol usually taken with meals	0.5	0.9	3.1	0.5	0.1	0.2	-1.3	-1.8	0.2
Nervous feelings	0.5	0.9	4.4	-0.4	0.3	0.5	0.8	-0.0	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	10.3	-3.2	2.1	1.4	1.3	-0.1	-0.5
Hearing difficulty/problems with background noise	0.4	0.7	1.5	1.1	1.1	1.2	0.5	0.3	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.4	0.3	-0.0	-1.2	-0.1	0.6	-0.0
Had menopause	0.5	0.7	2.8	-1.7	0.1	0.1	-1.0	-0.4	-0.4
Had other major operations	0.9	1.1	3.0	-0.9	1.0	-0.8	-0.5	-1.1	-1.7
Forced vital capacity (FVC)	0.1	0.3	1.0	0.0	-1.0	-0.6	0.2	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	4.6	10.6	26.9	-3.1	5.0	5.2	1.0	-0.4	1.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	7.4	0.3	-0.3	0.8	2.7	0.4	-0.4
Qualifications: None of the above	0.4	0.9	2.2	-0.4	-0.1	1.4	1.5	1.0	-0.4
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.1	1.1	-0.1	0.3	0.9	0.1
Mouth/teeth dental problems	0.6	1.0	2.9	-0.5	0.9	-0.4	-1.7	-1.3	-0.3
Heart attack	0.4	0.5	1.2	-1.0	-0.5	-0.2	-0.0	-0.5	-1.1
Allergy	1.5	3.4	7.5	-2.6	0.2	0.1	2.7	-0.7	-2.5
Pain all over the body in last month	0.7	0.8	3.5	0.8	0.4	-0.3	0.6	-0.2	1.9
Diabetes (self-reported)	1.8	2.8	10.7	-0.5	-1.4	-0.1	1.7	3.3	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.5	0.1	0.6	-0.4	-0.4	1.6	0.5
Medication: Ramipril	2.4	3.1	8.0	-0.9	2.4	1.8	2.8	0.2	-0.9
Medication: Simvastatin	1.3	1.9	5.3	-1.2	0.4	0.9	2.3	1.9	0.4
Fluid intelligence score	1.3	2.8	8.2	0.9	1.2	-1.0	-1.8	-2.9	-1.3
Illnesses of siblings	1.5	2.1	5.5	0.5	-2.3	-2.3	-0.8	-0.4	-0.8
Neuroticism score	0.4	0.9	1.5	-0.9	1.1	0.6	0.9	-0.8	-1.2
Weight	0.3	1.5	4.8	1.4	-0.7	-0.4	0.6	-2.2	-1.2
Impedance of arm (right)	0.3	1.3	4.6	2.2	-1.5	0.1	-0.7	-0.8	-0.1
Arm fat percentage (right)	0.1	0.6	1.1	0.6	-1.0	1.1	0.8	-0.6	0.3
Trunk fat-free mass	0.4	2.5	4.9	1.2	-1.0	-2.1	-0.2	-2.2	-1.8
Hip circumference	0.3	1.4	5.8	1.2	0.1	-0.1	-0.9	-2.4	-0.1
Time employed in main current job	0.9	1.1	5.2	0.2	0.5	-0.0	-1.0	-0.0	2.3
Alcohol intake versus 10 years previously	0.4	0.6	1.5	1.2	0.4	-0.8	-0.2	-0.2	-1.1
Father’s age at death	0.5	0.7	2.4	-1.6	0.1	0.6	0.4	-1.0	-0.4
Worrier / anxious feelings	0.2	0.4	1.5	-1.2	-0.3	0.6	0.2	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	1.3	0.4	0.2	0.1	-1.0	-0.5
Falls in the last year	0.8	1.1	3.3	-0.8	1.8	1.4	0.7	0.1	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-0.9	-0.4	1.0	0.0	-0.6	-1.1
Number of live births	0.9	1.3	4.6	-0.6	0.0	0.6	2.2	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.2	-0.5	-1.1	-0.8	0.5	-0.5	-0.7
Pulse rate	0.7	1.1	4.1	0.7	0.0	0.8	1.1	2.0	0.6
Happiness	0.9	1.1	3.3	-0.9	0.2	1.0	0.5	-1.0	-1.8
Noisy workplace	0.4	0.5	1.2	-0.4	0.3	0.6	1.0	1.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.6	-1.3	0.6	0.2	0.2	-0.5	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.0	0.5	-0.5	-0.4	0.1	1.7	1.4
Mouth/teeth dental problems: Dentures	0.7	1.1	3.4	1.9	-0.7	-0.2	0.5	-0.5	-1.5
Asthma	0.5	1.0	2.3	-0.9	1.5	1.3	-1.1	0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.3	-0.3	0.6	0.7	0.2	-0.8
Medication: Cholesterol lowering	0.8	1.2	4.2	-1.1	-0.1	0.6	2.1	1.2	0.4
Depression (self-reported)	1.1	1.3	2.8	-1.3	0.7	1.7	1.6	0.4	0.5
Medication: Lansoprazole	0.8	0.9	2.3	-1.5	0.8	1.1	0.7	0.9	-0.2
Prospective memory result	1.2	1.5	5.7	0.5	-2.4	-1.3	0.9	0.6	0.2
Lung cancer (father)	0.7	0.8	1.9	1.0	-1.2	-0.3	0.1	1.4	0.8
Illnesses of mother	0.6	0.7	2.1	0.3	-1.4	-0.7	-0.3	-1.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.4	-1.5	-0.7	-0.6	0.6	-1.0	-1.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.6	-0.3	0.8	0.4	1.3	0.3	1.1
Impedance of arm (left)	0.3	1.3	4.8	2.2	-1.4	0.3	-0.5	-0.5	0.6
Arm fat mass (right)	0.1	0.6	1.5	0.7	-0.7	0.5	0.6	-1.2	-0.5
Trunk predicted mass	0.4	2.5	5.2	1.2	-1.0	-2.0	-0.3	-2.3	-1.8
Standing height	0.9	9.4	17.4	4.2	-2.5	-3.4	-0.9	-3.8	-2.6
Length of working week for main job	0.6	0.6	1.8	0.3	0.7	-1.4	0.7	0.8	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.2	0.4	0.2	-0.8	0.9	1.1	-0.8
Breastfed as a baby	1.1	1.4	4.2	2.0	0.8	0.7	-0.7	0.8	1.3
Tense / ‘highly strung’	1.0	1.7	4.7	-0.4	1.6	1.5	2.2	0.6	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	3.6	-0.7	1.0	1.7	1.3	1.6	1.9
Hair/balding pattern: Pattern 4	0.5	1.2	4.6	-0.9	0.1	-0.5	0.5	-1.1	-2.1
Birth weight of first child	1.3	2.4	6.3	0.8	-1.9	-2.5	-1.5	-1.4	0.1
Peak expiratory flow (PEF)	0.4	1.0	2.8	0.6	-1.7	-1.5	0.1	-0.1	-0.8
Pulse wave reflection index	0.7	0.8	3.2	-0.4	1.8	0.9	0.2	-0.7	0.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.6	0.1	1.3	-0.7	1.5	-0.1	-1.9
Loud music exposure frequency	0.8	0.9	3.3	-1.0	0.7	0.3	-1.8	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.7	0.4	-0.1	0.0	-0.8	0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	3.8	-1.6	-0.3	0.7	1.9	0.9	1.0
Blood clot in the leg (DVT)	0.3	0.4	1.2	0.4	0.7	-0.4	-1.1	-0.8	0.1
Medication: Paracetamol	0.4	0.6	1.7	-1.0	0.5	1.3	-0.7	-0.3	-0.7
Headache pain in last month	0.4	0.8	1.4	0.5	0.6	-1.1	-0.5	-1.2	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	5.2	1.5	-0.5	-1.8	-2.3	-0.8	0.1
Glaucoma (self-reported)	0.9	1.0	3.1	0.9	-0.7	-0.8	-1.8	-0.0	1.1
Gout (self-reported)	2.4	3.3	7.2	-2.1	-0.7	1.6	2.7	2.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.2	-1.1	0.5	0.3	-0.7	-1.0	-0.9
Medication: Amlodipine	0.8	1.1	3.0	-0.8	0.2	1.7	0.8	1.4	0.5
Medication: Ventolin 100micrograms inhaler	2.1	2.6	7.2	1.4	-0.4	-0.1	-2.5	-0.2	2.7
Birth weight	1.6	3.5	8.5	1.4	-0.7	-1.8	-1.3	-2.9	-2.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	1.2	-1.0	0.2	-0.5	1.2	0.2
High blood pressure (siblings)	1.3	1.9	5.0	0.3	1.9	1.7	-0.1	0.2	2.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.0	-1.0	-0.7	-0.6	0.4	-0.7	-0.8
Body fat percentage	0.3	1.2	2.1	1.3	-1.0	1.4	0.8	-1.2	0.8
Leg fat percentage (right)	0.2	0.8	2.5	0.6	-0.6	1.6	0.8	-0.7	0.8
Arm fat-free mass (right)	0.2	1.0	2.5	0.9	-0.2	-1.4	0.2	-1.6	-0.8
Exposure to tobacco smoke outside home	1.0	1.4	2.8	0.6	0.9	-0.6	1.7	1.2	-1.6
Comparative body size at age 10	0.3	0.9	3.8	-1.9	0.8	0.2	-0.3	-0.9	-0.2
Number of full brothers	2.3	2.9	4.9	1.5	1.7	1.3	1.5	2.2	1.9
Worry too long after embarrassment	0.4	0.6	1.3	-0.3	1.1	1.0	-0.4	1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	4.3	-1.1	1.8	2.1	1.8	0.3	-0.4
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	-0.1	0.4	1.4	-1.2	0.0	1.5
Number of children fathered	2.6	2.9	10.0	1.4	0.5	2.3	0.3	0.2	3.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.6	-1.9	-0.8	-0.9	-0.9	0.1	-0.7
Age at first live birth	3.6	6.5	14.4	3.7	-1.4	-2.5	-3.8	-1.5	0.7
Pulse wave peak to peak time	0.6	0.7	1.6	0.4	-0.8	-0.4	-1.3	-0.6	-1.2
Health satisfaction	2.8	3.6	10.0	-1.4	1.1	1.8	3.2	2.2	-0.5
Shortness of breath walking on level ground	0.8	0.9	2.5	-0.7	1.6	-0.7	0.8	-0.3	-1.1
Qualifications: College or University degree	0.3	1.0	2.2	-0.6	-0.0	-1.0	-0.8	-1.3	-1.5
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.2	0.6	0.7	0.6	0.6	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.9	-0.6	-0.0	0.5	-0.2	-0.4	1.4
Emphysema/chronic bronchitis	0.4	0.5	1.0	0.5	-0.3	1.0	0.6	-1.0	0.6
Medication for pain relief, constipation, heartburn	0.3	0.4	1.3	-0.2	-0.2	-1.2	0.3	0.5	0.9
Neck or shoulder pain in last month	2.1	2.9	8.2	-2.0	2.9	1.4	1.6	0.4	-0.6
Medication: Blood pressure	0.2	0.3	1.5	-0.0	0.1	1.2	0.4	-0.3	0.3
Angina (self-reported)	0.3	0.4	1.1	-0.1	-0.6	-1.1	0.1	-0.2	-0.9
Migraine (self-reported)	0.2	0.2	0.5	-0.7	0.1	-0.2	-0.6	0.4	0.4
Medication: Ibuprofen	0.2	0.3	0.8	0.0	-0.3	0.1	0.9	0.1	-0.9
Medication: Allopurinol	3.9	5.2	9.8	-3.1	0.2	2.1	2.8	2.7	-1.2
Medication: Omeprazole	0.6	0.8	2.3	1.5	-0.4	-0.4	-0.1	0.3	1.3
Medication: Seretide 50 evohaler	0.3	0.3	1.2	0.5	0.3	-0.3	-0.2	0.4	1.1
Mean time to correctly identify matches	0.8	1.6	4.0	-0.2	0.2	1.6	1.0	2.0	1.2
Heart disease (mother)	1.0	1.2	4.2	0.3	0.8	1.0	1.0	2.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	6.6	1.0	1.4	2.6	0.2	0.9	1.6
Whole body fat mass	0.3	1.2	2.4	1.5	-1.2	0.5	0.9	-1.6	-0.1
Leg fat mass (right)	0.2	0.8	1.8	1.1	-1.0	0.5	0.7	-1.3	-0.2
Arm predicted mass (right)	0.2	1.2	3.3	0.9	-0.2	-1.5	-0.1	-1.8	-0.9
Pulse rate, automated reading	0.3	0.8	1.7	-0.8	1.3	0.3	0.7	1.2	-0.9
Alcohol intake frequency.	0.9	2.0	4.7	-1.5	1.8	-0.1	1.3	2.2	-0.5
Comparative height size at age 10	0.3	1.7	5.4	0.9	0.2	-0.3	0.6	-1.8	-2.3
Number of full sisters	2.8	3.4	7.7	-1.4	0.5	2.2	2.3	2.8	0.4
Suffer from ‘nerves’	1.3	2.1	3.5	-1.9	1.9	1.2	1.2	0.2	-1.5
Overall health rating	0.5	1.0	4.2	-0.0	-0.4	0.9	2.1	0.7	-0.5
Chest pain or discomfort	0.7	1.0	2.1	-0.7	0.5	1.1	1.4	0.5	-1.3
Had major operations	0.6	0.7	2.2	-1.5	0.4	0.2	1.0	-0.6	0.7
Age at last live birth	1.6	2.3	5.7	2.4	-1.3	-2.0	-1.5	-0.8	-0.3
Family relationship satisfaction	1.2	1.5	7.3	-0.2	0.2	0.4	1.1	-0.5	-2.7
Leg pain on walking	0.4	0.5	1.4	-1.2	0.3	-1.1	-0.1	0.4	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.8	-0.2	0.0	-0.4	0.5	1.3	0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.8	-0.7	-0.2	0.4	0.5	-1.3	-0.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.3	0.4	-0.3	0.8	-0.1	0.4	1.1
Medication: Aspirin	0.4	0.5	1.7	0.4	-1.3	-0.2	-0.1	0.6	0.8
Supplements: Vitamin C	1.5	1.7	6.0	1.1	-0.1	-0.5	-2.4	-0.9	1.5
Knee pain experienced in last month	1.3	2.0	4.7	-1.9	-1.2	-0.2	0.4	-1.5	-2.2
Hypertension (Self-reported)	0.5	1.3	2.7	0.3	1.3	1.6	1.6	0.8	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.0	9.1	-1.7	1.9	3.0	1.4	-0.7	0.4
Illnesses of father: Heart disease	1.6	2.3	4.3	-2.0	2.1	1.6	0.3	-0.8	-1.5
Illnesses of siblings: Diabetes	2.1	2.6	7.7	-0.9	0.3	2.2	2.8	1.4	0.6
Smoking status: Previous	1.0	1.5	6.0	0.5	-1.3	0.1	2.4	0.9	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.5	0.2	-0.7	-0.5	1.1	-1.0	-1.2
Whole body fat-free mass	0.4	2.3	4.9	1.3	-0.9	-1.9	-0.1	-2.2	-1.7
Leg fat-free mass (right)	0.4	1.9	4.1	1.0	-1.1	-1.6	0.2	-2.0	-1.7
Arm fat percentage (left)	0.2	0.6	1.1	0.7	-1.0	1.0	0.9	-0.4	0.6
Average weekly red wine intake	0.4	0.6	1.4	-0.3	-0.4	1.0	-0.9	0.2	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.8	-0.3	-0.2	-0.3	-1.4	-1.3	-0.6
Mood swings	0.2	0.3	0.9	-0.2	1.0	0.4	0.9	0.1	0.2
Loneliness, isolation	1.7	2.4	4.5	-0.8	1.6	1.6	1.0	-1.9	-2.1
Long-standing illness, disability or infirmity	1.2	1.8	4.2	-1.2	-0.4	0.4	1.7	2.1	1.4
Ever had bowel cancer screening	0.9	1.1	6.4	-0.0	-0.1	0.0	-0.1	-2.5	0.2
Diabetes diagnosed by doctor	1.5	2.5	8.4	-0.9	-1.3	-0.1	1.8	2.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	4.2	-0.6	2.1	1.5	-0.6	-0.4	0.2
Friendships satisfaction	0.4	0.5	1.3	-0.2	-0.6	0.7	1.1	-0.0	-1.1
Qualifications: nursing, teaching	0.9	1.5	5.9	1.6	0.6	0.3	-0.2	-2.4	-0.1
Commuting to job workplace: Walk	0.7	0.7	1.8	-0.5	0.8	0.0	0.8	1.4	-0.9
Eye problems/disorders: Cataract	0.5	0.5	1.7	0.5	-0.6	-0.6	-0.1	-1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	4.9	-0.6	-0.0	-0.7	1.3	2.2	0.7
Medication for cholesterol	1.0	1.6	2.9	0.2	-1.6	-1.2	-0.9	-1.3	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.6	0.2	-0.7	0.6	0.0	-0.5
Back pain experienced in last month	0.9	1.3	3.1	-0.4	-0.0	1.7	1.4	1.1	1.2
Mineral and other dietary supplements	0.5	0.6	2.1	0.3	-0.4	-0.1	0.2	-1.2	-1.4
Breast cancer (self-reported)	2.9	3.5	11.1	-0.7	-1.2	-3.3	-1.1	-1.5	-2.1
Asthma (self-reported)	0.5	0.9	2.2	-0.2	1.5	1.0	-1.5	-0.4	0.2
Osteoporosis (self-reported)	0.4	0.6	1.6	1.2	0.4	-0.6	-0.5	0.6	0.8
Osteoarthritis (self-reported)	0.5	0.6	1.5	-0.9	1.2	0.1	1.0	0.5	0.4
Medication: Aspirin	0.5	0.7	1.7	0.6	-1.3	-0.3	-0.2	0.8	1.1
Medication: Gliclazide	1.1	1.2	4.7	-1.1	-0.3	0.5	0.8	2.2	0.8
Illnesses of father: None of the above (group 1)	0.8	0.9	2.9	0.6	-0.8	-1.7	-0.8	-0.1	-1.1
Smoking status: Current	0.1	0.2	0.9	-0.1	0.1	0.9	0.5	0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.6	-2.2	0.8	1.1	1.9	0.4	-1.6
Whole body water mass	0.4	2.2	4.3	1.3	-0.9	-1.9	-0.0	-2.1	-1.7
Leg predicted mass (right)	0.4	1.9	3.9	1.0	-1.1	-1.6	0.2	-2.0	-1.6
Arm fat mass (left)	0.1	0.6	1.1	1.0	-0.9	0.4	0.5	-1.0	-0.2
Number of self-reported non-cancer illnesses	0.8	1.3	2.6	0.0	0.6	1.3	1.1	1.4	1.6
Average weekly champagne plus white wine intake	0.7	0.9	2.6	-0.6	0.0	-0.5	1.6	0.1	-1.5
Miserableness	0.3	0.5	1.5	0.7	-0.2	-0.9	0.2	-0.5	-1.2
Guilty feelings	1.2	1.8	8.0	0.3	0.1	-0.1	-0.3	-2.8	-1.7
Wears glasses or contact lenses	0.2	0.3	0.5	0.7	0.6	0.4	0.3	0.2	0.7
Ever taken oral contraceptive pill	0.4	0.5	1.8	-0.4	0.6	0.1	0.4	-0.7	-1.3
Hearing aid user	1.4	1.6	5.2	0.6	-0.5	-1.8	-2.3	0.1	0.6
Mother’s age at death	0.6	0.7	1.5	0.7	0.2	-1.2	-0.9	-1.2	0.0
Financial situation satisfaction	0.6	0.8	1.8	-0.9	1.0	0.7	1.3	0.2	-0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.6	1.3	-1.3	-1.9	0.7	1.1	-0.4
Commuting to job workplace: Public transport	0.6	0.7	2.8	-0.5	-0.5	-0.0	-0.4	1.7	0.8
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	-0.9	0.5	0.8	-0.9	0.0	-0.3
Medication: Blood pressure	0.9	1.8	2.7	-0.2	1.1	1.2	1.6	1.5	1.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.7	0.3	-1.4	0.2	-0.2	-1.6	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	0.0	-0.6	-0.6	-1.5	0.1	1.5
High cholesterol (Self-reported)	0.5	0.8	2.4	-0.9	0.2	-0.4	1.2	1.5	-0.1
Medication: Bendroflumethiazide	0.6	0.9	1.5	0.8	-1.0	-0.3	0.7	1.2	1.2
Medication: Paracetamol	0.2	0.2	0.8	-0.3	-0.3	0.9	-0.5	-0.4	-0.3
Medication: Lisinopril	0.8	1.1	2.6	-0.1	-1.6	0.9	1.2	1.2	0.3
Medication: Atorvastatin	1.4	1.7	5.0	-2.2	-0.8	0.7	1.5	0.5	-1.2
Illnesses of father: High blood pressure	0.5	0.6	1.8	-0.4	1.4	0.6	0.9	0.5	-0.2
Alcohol drinker status: Never	1.7	2.0	3.9	-0.1	-1.8	-1.4	-0.4	2.0	1.6
Ever smoked	0.9	1.6	6.9	-0.8	0.0	1.1	2.6	0.7	-0.6
Basal metabolic rate	0.4	2.0	4.5	1.4	-0.9	-1.6	0.1	-2.1	-1.5
Leg fat percentage (left)	0.2	0.9	2.5	0.3	-0.9	1.6	0.7	-0.9	0.8
Arm fat-free mass (left)	0.3	1.7	4.0	1.2	-0.8	-1.5	-0.4	-2.0	-1.4
Number of operations (self-reported)	0.4	0.6	1.6	-1.3	0.6	-0.9	0.8	-0.5	-0.4
Average weekly beer plus cider intake	0.9	1.4	5.8	0.6	0.1	-0.4	0.5	2.4	1.3
Irritability	0.2	0.4	1.1	0.5	-0.9	-1.1	0.3	0.2	-0.0
Risk taking	1.0	1.5	5.7	0.0	0.2	-1.0	-0.3	-1.5	-2.4
Ever had prostate specific antigen (PSA) test	0.7	0.9	3.2	0.3	1.8	0.5	-1.1	-0.1	0.5
Fractured/broken bones in last 5 years	1.0	1.3	2.7	1.2	-0.7	-1.2	-1.6	-0.4	1.1
Age started oral contraceptive pill	1.6	1.9	7.7	1.4	-0.9	-0.8	-2.8	-0.7	0.2
Diastolic blood pressure, automated reading	0.5	1.5	4.5	-2.1	0.2	1.0	0.9	-0.6	-1.6
Ever depressed for a whole week	1.3	1.6	3.0	-1.6	1.0	1.7	1.7	-0.6	-0.1
Unable to work because of sickness or disability	0.5	0.7	3.6	-1.9	0.1	-0.0	0.3	0.2	0.3
Commuting to job workplace: Cycle	0.2	0.3	1.5	-0.1	0.0	-1.2	-0.2	-0.5	0.1
Myopia	0.8	1.1	4.5	0.8	-0.2	-0.6	0.8	2.1	0.6
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.7	0.1	-1.3	-2.2	-1.8	-1.4	-1.6
Cholesterol lowering medication	0.3	0.4	1.1	-0.4	-0.4	0.1	0.5	0.8	1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.6	0.6	0.1	0.0	0.0	0.2	1.3
Pain experienced in last month	0.4	0.6	1.4	1.2	-0.7	-0.4	-0.9	0.8	-0.2
Supplements: Calcium	1.1	1.3	4.6	2.1	0.2	-0.3	-0.3	0.8	1.4
Basal cell carcinoma (self-reported)	0.9	1.1	2.1	-1.5	-1.3	-1.0	1.3	0.3	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	-1.1	-0.4	-0.2	0.3	-0.4	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	0.3	0.7	-0.4	-1.0	-0.8	0.1
Heart disease (siblings)	0.2	0.3	0.9	-0.0	-0.6	0.1	-0.6	0.4	0.9
Alcohol drinker status: Previous	1.0	1.1	3.2	0.7	-0.1	-1.8	1.1	1.1	-0.9
Pack years of smoking	0.4	0.7	1.5	0.1	-1.2	0.1	-1.1	-1.0	-0.0
Impedance of whole body	0.2	0.9	3.2	1.8	-1.3	0.4	-0.4	-0.2	0.6
Leg fat mass (left)	0.2	0.7	1.7	0.8	-1.1	0.5	0.7	-1.3	-0.2
Arm predicted mass (left)	0.3	1.6	3.6	1.1	-0.5	-1.7	-0.2	-1.9	-1.3