[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr11:77,027,574-78,979,645

Best TWAS P=4.02e-16 · Best GWAS P=3.62e-16 conditioned to 0.129

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	GAB2	0.06	0.06	blup	100	0.07	7.8e-08	-7.4	8.1	4.0e-16	-0.94	0.06	0.94	TRUE
14	GTEx	Esophagus Muscularis	GAB2	0.05	0.04	lasso	7	0.04	1.8e-03	-7.6	8.0	1.5e-15	-0.89	0.13	0.79	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	GAB2	0.04	0.04	blup	100	0.04	1.4e-03	-7.6	7.8	5.2e-15	-0.91	0.09	0.79	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	GAB2	0.10	0.07	blup	100	0.09	8.8e-04	-7.4	7.8	5.6e-15	-0.93	0.05	0.61	FALSE
11	GTEx	Brain Cerebellar Hemisphere	NARS2	0.17	0.10	lasso	6	0.10	1.5e-03	-6.9	7.6	3.4e-14	-0.76	0.13	0.64	FALSE
10	GTEx	Brain Cerebellar Hemisphere	USP35	0.19	0.07	enet	13	0.09	2.5e-03	-7.6	-7.6	4.2e-14	0.87	0.12	0.54	FALSE
2	CommonMind	Brain Pre-frontal Cortex	USP35	0.06	0.05	blup	363	0.04	1.6e-05	-7.0	-7.5	5.8e-14	0.67	0.35	0.49	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NARS2	0.09	0.04	blup	60	0.04	5.9e-03	-7.0	7.5	6.1e-14	-0.73	0.10	0.23	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RP11-7I15.3	0.07	0.01	lasso	3	0.02	3.5e-02	-7.4	-7.5	8.4e-14	0.79	0.13	0.50	FALSE
28	METSIM	Adipose	USP35	0.05	0.05	lasso	11	0.04	3.0e-06	-7.4	-7.5	8.4e-14	0.89	0.44	0.56	FALSE
8	GTEx	Artery Tibial	GAB2	0.06	0.00	lasso	2	0.01	2.4e-02	-7.4	7.4	1.1e-13	-0.90	0.11	0.58	FALSE
23	GTEx	Stomach	NARS2	0.27	0.05	lasso	8	0.06	6.1e-04	-6.8	7.4	1.1e-13	-0.57	0.20	0.08	FALSE
24	GTEx	Testis	USP35	0.07	0.06	lasso	2	0.07	6.4e-04	-7.3	-7.3	2.3e-13	0.89	0.08	0.86	FALSE
4	GTEx	Adipose Visceral Omentum	ALG8	0.11	0.01	enet	8	0.02	3.7e-02	-7.6	-7.2	4.6e-13	0.73	0.15	0.34	FALSE
19	GTEx	Muscle Skeletal	NARS2	0.19	0.05	lasso	2	0.04	1.1e-04	-6.8	7.0	2.1e-12	-0.69	0.29	0.03	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	NARS2	0.24	0.13	lasso	2	0.13	3.1e-14	-7.0	7.0	2.7e-12	-0.69	0.96	0.04	FALSE
16	GTEx	Esophagus Muscularis	RP11-452H21.1	0.10	0.08	lasso	6	0.07	2.6e-05	-6.9	7.0	3.4e-12	-0.69	0.76	0.13	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	NARS2	0.15	0.22	lasso	5	0.20	9.6e-08	-6.9	7.0	3.5e-12	-0.70	0.92	0.06	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NARS2	0.11	0.04	lasso	3	0.04	9.9e-06	-7.0	6.9	3.7e-12	-0.70	0.73	0.16	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NARS2	0.14	0.06	lasso	2	0.06	2.9e-07	-6.9	6.9	4.4e-12	-0.70	0.96	0.04	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	NARS2	0.17	0.17	lasso	2	0.17	1.8e-21	-6.8	6.9	5.2e-12	-0.70	0.98	0.02	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	NARS2	0.30	0.19	lasso	2	0.17	2.6e-17	-6.9	6.9	5.5e-12	-0.70	0.97	0.03	FALSE
7	GTEx	Artery Coronary	NARS2	0.19	0.20	lasso	2	0.17	2.7e-06	-6.8	6.9	5.9e-12	-0.70	0.64	0.28	FALSE
18	GTEx	Lung	NARS2	0.21	0.20	lasso	3	0.21	3.5e-16	-6.9	6.9	6.0e-12	-0.70	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	NARS2	0.19	0.12	lasso	5	0.09	3.6e-08	-6.8	6.9	6.1e-12	-0.73	0.82	0.17	FALSE
6	GTEx	Artery Aorta	NARS2	0.26	0.29	lasso	2	0.28	1.7e-15	-6.8	6.9	6.3e-12	-0.70	0.98	0.02	FALSE
20	GTEx	Nerve Tibial	NARS2	0.20	0.18	lasso	3	0.18	2.0e-12	-6.8	6.9	6.6e-12	-0.70	0.98	0.02	FALSE
9	GTEx	Artery Tibial	NARS2	0.18	0.20	lasso	2	0.19	5.9e-15	-6.8	6.9	7.2e-12	-0.70	0.98	0.02	FALSE
44	The Cancer Genome Atlas	Soft Tissue Sarcoma	NARS2	0.11	0.05	enet	7	0.06	2.0e-04	-6.9	6.8	8.1e-12	-0.62	0.12	0.56	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	RP11-452H21.1	0.19	0.19	lasso	5	0.20	7.7e-08	-7.0	6.8	9.6e-12	-0.71	0.64	0.26	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	NARS2	0.27	0.27	lasso	4	0.27	1.9e-26	-6.7	6.8	9.7e-12	-0.70	0.99	0.01	FALSE
15	GTEx	Esophagus Muscularis	NARS2	0.25	0.19	lasso	3	0.17	8.7e-11	-6.8	6.8	1.1e-11	-0.70	0.98	0.02	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	NARS2	0.12	0.05	lasso	2	0.05	2.0e-10	-6.7	6.8	1.4e-11	-0.69	0.98	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NARS2	0.44	0.57	bslmm	502	0.56	2.1e-81	-6.8	6.7	1.7e-11	-0.69	0.98	0.02	FALSE
25	GTEx	Thyroid	NARS2	0.30	0.30	lasso	4	0.32	1.4e-24	-6.9	6.7	2.2e-11	-0.69	0.98	0.02	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NARS2	0.20	0.21	lasso	9	0.20	5.6e-09	-6.7	6.7	2.5e-11	-0.69	0.50	0.50	FALSE
17	GTEx	Liver	GAB2	0.17	-0.01	enet	20	-0.01	5.6e-01	-7.3	-6.6	4.7e-11	0.74	0.04	0.53	FALSE
26	GTEx	Thyroid	RP11-452H21.1	0.13	0.06	lasso	4	0.03	3.6e-03	-7.0	6.5	9.3e-11	-0.69	0.74	0.09	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	GAB2	0.05	0.00	blup	435	0.02	8.0e-04	-6.7	6.4	1.9e-10	-0.81	0.11	0.84	FALSE
5	GTEx	Adrenal Gland	NARS2	0.43	0.09	enet	47	0.22	2.6e-08	-6.8	6.2	5.3e-10	-0.44	0.54	0.26	FALSE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	NARS2	0.19	0.14	lasso	2	0.13	9.8e-05	-6.9	6.2	6.6e-10	-0.68	0.10	0.53	FALSE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	NARS2	0.17	0.09	enet	10	0.10	1.6e-11	-6.9	5.9	3.6e-09	-0.61	0.98	0.02	FALSE
22	GTEx	Skin Sun Exposed Lower leg	GAB2	0.06	0.01	enet	26	0.03	2.2e-03	-7.5	5.6	1.8e-08	-0.71	0.11	0.84	FALSE
39	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NARS2	0.11	0.01	enet	10	0.04	1.2e-03	-7.0	5.6	2.2e-08	-0.61	0.03	0.22	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCTD21	0.03	0.00	blup	51	0.01	7.2e-02	-7.4	5.6	2.2e-08	-0.77	0.01	0.65	FALSE
27	METSIM	Adipose	NARS2	0.10	0.06	bslmm	487	0.06	7.2e-10	-6.8	5.2	2.6e-07	-0.32	0.98	0.02	FALSE