Best TWAS P=1.38e-19 · Best GWAS P=1.37e-34 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-295H24.3 | 0.25 | 0.19 | lasso | 10 | 0.12 | 4.1e-05 | 6.92 | 7.3 | 2.6e-13 | -0.04 | 0.42 | 0.15 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP11-295H24.3 | 0.30 | 0.03 | enet | 34 | 0.11 | 8.4e-04 | 4.71 | 6.7 | 1.5e-11 | 0.13 | 0.10 | 0.05 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | FAM227B | 0.21 | 0.10 | enet | 28 | 0.11 | 2.4e-06 | 5.34 | 7.3 | 3.6e-13 | 0.29 | 0.18 | 0.53 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | RP11-295H24.3 | 0.11 | 0.06 | lasso | 5 | 0.04 | 2.7e-03 | 6.92 | 6.2 | 4.7e-10 | -0.11 | 0.33 | 0.03 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | SPPL2A | 0.36 | -0.01 | enet | 13 | 0.09 | 4.3e-03 | 0.26 | -5.6 | 2.0e-08 | 0.03 | 0.05 | 0.29 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | FAM227B | 0.11 | -0.01 | enet | 42 | 0.00 | 4.1e-01 | -4.48 | 8.4 | 4.1e-17 | 0.28 | 0.06 | 0.10 | TRUE |
| 7 | GTEx | Cells EBV-transformed lymphocytes | GALK2 | 0.18 | 0.03 | lasso | 6 | 0.05 | 1.2e-02 | 9.69 | 7.5 | 5.7e-14 | -0.01 | 0.31 | 0.04 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | RP11-295H24.3 | 0.11 | 0.08 | enet | 20 | 0.07 | 7.9e-06 | 6.92 | 5.1 | 2.9e-07 | -0.14 | 0.95 | 0.00 | TRUE |
| 9 | GTEx | Esophagus Mucosa | ATP8B4 | 0.10 | 0.01 | enet | 28 | 0.02 | 2.7e-02 | 3.05 | 7.4 | 1.0e-13 | 0.06 | 0.10 | 0.04 | FALSE |
| 10 | GTEx | Esophagus Mucosa | RP11-295H24.3 | 0.07 | 0.08 | lasso | 4 | 0.07 | 1.6e-05 | 5.22 | 6.5 | 9.1e-11 | -0.12 | 0.89 | 0.00 | TRUE |
| 11 | GTEx | Esophagus Muscularis | USP8 | 0.13 | 0.00 | enet | 37 | 0.08 | 2.5e-05 | -6.99 | -5.9 | 4.1e-09 | 0.09 | 0.04 | 0.80 | FALSE |
| 12 | GTEx | Esophagus Muscularis | SPPL2A | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.8e-07 | -6.63 | -6.4 | 1.3e-10 | 0.02 | 0.01 | 0.99 | FALSE |
| 13 | GTEx | Heart Atrial Appendage | SPPL2A | 0.07 | 0.10 | lasso | 3 | 0.09 | 6.5e-05 | -6.63 | -7.0 | 3.1e-12 | 0.01 | 0.03 | 0.93 | TRUE |
| 14 | GTEx | Liver | RP11-295H24.3 | 0.22 | 0.20 | lasso | 4 | 0.16 | 3.5e-05 | 7.23 | 6.3 | 3.5e-10 | -0.10 | 0.29 | 0.06 | FALSE |
| 15 | GTEx | Lung | SPPL2A | 0.08 | 0.08 | lasso | 4 | 0.07 | 6.0e-06 | -5.60 | -5.9 | 3.7e-09 | 0.00 | 0.28 | 0.64 | FALSE |
| 16 | GTEx | Lung | RP11-295H24.3 | 0.09 | 0.09 | lasso | 4 | 0.09 | 3.9e-07 | 6.92 | 7.3 | 3.4e-13 | -0.05 | 0.94 | 0.00 | FALSE |
| 17 | GTEx | Muscle Skeletal | FAM227B | 0.09 | 0.03 | enet | 17 | 0.09 | 7.5e-09 | -7.57 | -6.0 | 2.2e-09 | 0.09 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Nerve Tibial | SPPL2A | 0.12 | 0.10 | lasso | 4 | 0.09 | 4.8e-07 | -6.75 | -5.8 | 8.1e-09 | -0.01 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Pancreas | RP11-295H24.3 | 0.16 | 0.17 | lasso | 5 | 0.15 | 9.8e-07 | 5.00 | 5.5 | 5.0e-08 | -0.16 | 0.95 | 0.00 | FALSE |
| 20 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-295H24.3 | 0.09 | 0.08 | lasso | 3 | 0.08 | 5.4e-05 | 6.92 | 8.0 | 1.1e-15 | 0.15 | 0.20 | 0.05 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | FAM227B | 0.09 | 0.02 | lasso | 3 | 0.04 | 2.0e-04 | 8.67 | -6.9 | 4.4e-12 | -0.02 | 0.43 | 0.03 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | RP11-295H24.3 | 0.08 | 0.05 | lasso | 2 | 0.05 | 7.7e-05 | 7.23 | 7.1 | 9.7e-13 | -0.07 | 0.78 | 0.01 | FALSE |
| 23 | GTEx | Small Intestine Terminal Ileum | RP11-295H24.3 | 0.27 | 0.07 | lasso | 5 | 0.12 | 1.4e-03 | 7.23 | 6.2 | 5.7e-10 | -0.18 | 0.15 | 0.08 | FALSE |
| 24 | GTEx | Spleen | RP11-295H24.3 | 0.22 | 0.24 | lasso | 2 | 0.20 | 9.7e-06 | 6.92 | 6.9 | 4.3e-12 | -0.07 | 0.29 | 0.06 | FALSE |
| 25 | GTEx | Stomach | RP11-295H24.3 | 0.08 | 0.11 | lasso | 2 | 0.08 | 8.9e-05 | 6.92 | 6.9 | 4.3e-12 | -0.07 | 0.42 | 0.03 | FALSE |
| 26 | GTEx | Thyroid | SECISBP2L | 0.06 | 0.05 | enet | 7 | 0.06 | 1.7e-05 | 9.69 | 7.8 | 8.6e-15 | 0.11 | 0.46 | 0.02 | FALSE |
| 27 | GTEx | Thyroid | RP11-295H24.3 | 0.14 | 0.08 | enet | 13 | 0.10 | 3.1e-08 | 6.92 | 7.0 | 2.7e-12 | 0.01 | 1.00 | 0.00 | FALSE |
| 28 | NTR | Blood | DTWD1 | 0.03 | 0.03 | lasso | 5 | 0.03 | 8.3e-09 | -7.80 | -7.2 | 5.3e-13 | -0.23 | 1.00 | 0.00 | TRUE |
| 29 | YFS | Blood | USP8 | 0.02 | 0.01 | blup | 426 | 0.01 | 2.4e-05 | -5.15 | -6.8 | 7.4e-12 | 0.02 | 0.16 | 0.80 | FALSE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP4E1 | 0.02 | 0.02 | lasso | 3 | 0.01 | 9.5e-04 | -5.60 | -5.8 | 6.1e-09 | 0.02 | 0.03 | 0.95 | FALSE |
| 31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DTWD1 | 0.06 | 0.04 | enet | 8 | 0.05 | 1.1e-10 | 2.50 | 8.6 | 1.1e-17 | 0.52 | 1.00 | 0.00 | TRUE |
| 32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC100132724 | 0.02 | 0.01 | lasso | 3 | 0.01 | 1.6e-03 | -5.54 | -5.3 | 9.2e-08 | 0.03 | 0.00 | 0.97 | FALSE |
| 33 | The Cancer Genome Atlas | Glioblastoma Multiforme | SPPL2A | 0.22 | 0.13 | lasso | 1 | 0.09 | 9.4e-04 | -6.71 | -6.7 | 1.9e-11 | 0.02 | 0.00 | 0.90 | FALSE |
| 34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TNFAIP8L3 | 0.03 | 0.00 | blup | 41 | 0.01 | 8.3e-03 | -4.98 | -5.5 | 4.1e-08 | -0.03 | 0.01 | 0.25 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | SPPL2A | 0.07 | 0.06 | lasso | 2 | 0.05 | 9.3e-07 | -6.63 | -6.7 | 2.6e-11 | 0.02 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DTWD1 | 0.04 | 0.04 | blup | 27 | 0.03 | 9.5e-05 | -2.54 | -5.7 | 1.1e-08 | -0.24 | 0.12 | 0.04 | TRUE |
| 37 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SPPL2A | 0.43 | 0.35 | enet | 9 | 0.34 | 2.1e-14 | -6.75 | -6.4 | 1.7e-10 | 0.03 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | SECISBP2L | 0.08 | 0.06 | enet | 8 | 0.06 | 6.4e-07 | 9.69 | 9.1 | 1.4e-19 | 0.09 | 0.00 | 1.00 | TRUE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | SPPL2A | 0.25 | 0.17 | blup | 39 | 0.24 | 7.3e-23 | -6.71 | -5.5 | 4.2e-08 | 0.00 | 0.00 | 1.00 | FALSE |