[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr15:48,584,083-51,750,846

Best TWAS P=1.38e-19 · Best GWAS P=1.37e-34 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
38	The Cancer Genome Atlas	Thyroid Carcinoma	SECISBP2L	0.08	0.06	enet	8	0.06	6.4e-07	9.69	9.1	1.4e-19	0.09	0.00	1.00	TRUE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	DTWD1	0.06	0.04	enet	8	0.05	1.1e-10	2.50	8.6	1.1e-17	0.52	1.00	0.00	TRUE
6	GTEx	Breast Mammary Tissue (Female)	FAM227B	0.11	-0.01	enet	42	0.00	4.1e-01	-4.48	8.4	4.1e-17	0.28	0.06	0.10	TRUE
3	GTEx	Breast Mammary Tissue	FAM227B	0.21	0.10	enet	28	0.11	2.4e-06	5.34	7.3	3.6e-13	0.29	0.18	0.53	TRUE
28	NTR	Blood	DTWD1	0.03	0.03	lasso	5	0.03	8.3e-09	-7.80	-7.2	5.3e-13	-0.23	1.00	0.00	TRUE
13	GTEx	Heart Atrial Appendage	SPPL2A	0.07	0.10	lasso	3	0.09	6.5e-05	-6.63	-7.0	3.1e-12	0.01	0.03	0.93	TRUE
10	GTEx	Esophagus Mucosa	RP11-295H24.3	0.07	0.08	lasso	4	0.07	1.6e-05	5.22	6.5	9.1e-11	-0.12	0.89	0.00	TRUE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DTWD1	0.04	0.04	blup	27	0.03	9.5e-05	-2.54	-5.7	1.1e-08	-0.24	0.12	0.04	TRUE
8	GTEx	Cells Transformed fibroblasts	RP11-295H24.3	0.11	0.08	enet	20	0.07	7.9e-06	6.92	5.1	2.9e-07	-0.14	0.95	0.00	TRUE
20	GTEx	Skin Not Sun Exposed Suprapubic	RP11-295H24.3	0.09	0.08	lasso	3	0.08	5.4e-05	6.92	8.0	1.1e-15	0.15	0.20	0.05	FALSE
26	GTEx	Thyroid	SECISBP2L	0.06	0.05	enet	7	0.06	1.7e-05	9.69	7.8	8.6e-15	0.11	0.46	0.02	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	GALK2	0.18	0.03	lasso	6	0.05	1.2e-02	9.69	7.5	5.7e-14	-0.01	0.31	0.04	FALSE
9	GTEx	Esophagus Mucosa	ATP8B4	0.10	0.01	enet	28	0.02	2.7e-02	3.05	7.4	1.0e-13	0.06	0.10	0.04	FALSE
1	GTEx	Adrenal Gland	RP11-295H24.3	0.25	0.19	lasso	10	0.12	4.1e-05	6.92	7.3	2.6e-13	-0.04	0.42	0.15	FALSE
16	GTEx	Lung	RP11-295H24.3	0.09	0.09	lasso	4	0.09	3.9e-07	6.92	7.3	3.4e-13	-0.05	0.94	0.00	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RP11-295H24.3	0.08	0.05	lasso	2	0.05	7.7e-05	7.23	7.1	9.7e-13	-0.07	0.78	0.01	FALSE
27	GTEx	Thyroid	RP11-295H24.3	0.14	0.08	enet	13	0.10	3.1e-08	6.92	7.0	2.7e-12	0.01	1.00	0.00	FALSE
24	GTEx	Spleen	RP11-295H24.3	0.22	0.24	lasso	2	0.20	9.7e-06	6.92	6.9	4.3e-12	-0.07	0.29	0.06	FALSE
25	GTEx	Stomach	RP11-295H24.3	0.08	0.11	lasso	2	0.08	8.9e-05	6.92	6.9	4.3e-12	-0.07	0.42	0.03	FALSE
21	GTEx	Skin Sun Exposed Lower leg	FAM227B	0.09	0.02	lasso	3	0.04	2.0e-04	8.67	-6.9	4.4e-12	-0.02	0.43	0.03	FALSE
29	YFS	Blood	USP8	0.02	0.01	blup	426	0.01	2.4e-05	-5.15	-6.8	7.4e-12	0.02	0.16	0.80	FALSE
2	GTEx	Brain Cerebellar Hemisphere	RP11-295H24.3	0.30	0.03	enet	34	0.11	8.4e-04	4.71	6.7	1.5e-11	0.13	0.10	0.05	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	SPPL2A	0.22	0.13	lasso	1	0.09	9.4e-04	-6.71	-6.7	1.9e-11	0.02	0.00	0.90	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	SPPL2A	0.07	0.06	lasso	2	0.05	9.3e-07	-6.63	-6.7	2.6e-11	0.02	0.00	1.00	FALSE
12	GTEx	Esophagus Muscularis	SPPL2A	0.19	0.13	lasso	5	0.11	2.8e-07	-6.63	-6.4	1.3e-10	0.02	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPPL2A	0.43	0.35	enet	9	0.34	2.1e-14	-6.75	-6.4	1.7e-10	0.03	0.00	1.00	FALSE
14	GTEx	Liver	RP11-295H24.3	0.22	0.20	lasso	4	0.16	3.5e-05	7.23	6.3	3.5e-10	-0.10	0.29	0.06	FALSE
4	GTEx	Breast Mammary Tissue	RP11-295H24.3	0.11	0.06	lasso	5	0.04	2.7e-03	6.92	6.2	4.7e-10	-0.11	0.33	0.03	FALSE
23	GTEx	Small Intestine Terminal Ileum	RP11-295H24.3	0.27	0.07	lasso	5	0.12	1.4e-03	7.23	6.2	5.7e-10	-0.18	0.15	0.08	FALSE
17	GTEx	Muscle Skeletal	FAM227B	0.09	0.03	enet	17	0.09	7.5e-09	-7.57	-6.0	2.2e-09	0.09	1.00	0.00	FALSE
15	GTEx	Lung	SPPL2A	0.08	0.08	lasso	4	0.07	6.0e-06	-5.60	-5.9	3.7e-09	0.00	0.28	0.64	FALSE
11	GTEx	Esophagus Muscularis	USP8	0.13	0.00	enet	37	0.08	2.5e-05	-6.99	-5.9	4.1e-09	0.09	0.04	0.80	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP4E1	0.02	0.02	lasso	3	0.01	9.5e-04	-5.60	-5.8	6.1e-09	0.02	0.03	0.95	FALSE
18	GTEx	Nerve Tibial	SPPL2A	0.12	0.10	lasso	4	0.09	4.8e-07	-6.75	-5.8	8.1e-09	-0.01	0.01	0.99	FALSE
5	GTEx	Breast Mammary Tissue (Male)	SPPL2A	0.36	-0.01	enet	13	0.09	4.3e-03	0.26	-5.6	2.0e-08	0.03	0.05	0.29	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TNFAIP8L3	0.03	0.00	blup	41	0.01	8.3e-03	-4.98	-5.5	4.1e-08	-0.03	0.01	0.25	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL2A	0.25	0.17	blup	39	0.24	7.3e-23	-6.71	-5.5	4.2e-08	0.00	0.00	1.00	FALSE
19	GTEx	Pancreas	RP11-295H24.3	0.16	0.17	lasso	5	0.15	9.8e-07	5.00	5.5	5.0e-08	-0.16	0.95	0.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100132724	0.02	0.01	lasso	3	0.01	1.6e-03	-5.54	-5.3	9.2e-08	0.03	0.00	0.97	FALSE