Hub : Genes

DTWD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0830 0.0360 3.7e-04 0.054 0.031 0.024 0.037 0.037 3.3e-07 9.3e-05 5.0e-04 2.1e-05 2.4e-05
2 GTEx Cells Transformed fibroblasts 0.1460 0.0440 3.8e-07 0.075 NA 0.108 NA 0.122 2.8e-06 NA 1.9e-08 NA 2.0e-09
3 GTEx Thyroid 0.0940 0.0360 2.9e-04 0.035 NA 0.020 NA 0.011 9.7e-04 NA 9.9e-03 NA 4.2e-02
4 NTR Blood 0.0255 0.0089 3.9e-06 0.028 0.019 0.025 0.022 0.026 2.2e-09 4.6e-07 1.3e-08 1.1e-07 8.3e-09
5 TCGA Bladder Urothelial Carcinoma 0.0380 0.0230 2.7e-03 0.036 0.036 0.040 NA 0.032 5.1e-04 4.8e-04 2.4e-04 NA 9.9e-04
6 TCGA Breast Invasive Carcinoma 0.0585 0.0223 2.5e-09 0.041 0.048 0.051 NA 0.050 5.9e-09 3.7e-10 1.1e-10 NA 1.4e-10
7 TCGA Colon Adenocarcinoma 0.1680 0.0630 1.6e-06 0.103 0.077 0.068 NA 0.073 1.6e-06 3.1e-05 8.9e-05 NA 4.9e-05
8 TCGA Head and Neck Squamous Cell Carcinoma 0.0578 0.0255 2.2e-06 0.076 0.054 0.071 NA 0.073 6.2e-09 1.1e-06 2.2e-08 NA 1.3e-08
9 TCGA Kidney Renal Clear Cell Carcinoma 0.1202 0.0473 1.7e-12 0.086 0.095 0.095 NA 0.126 6.2e-10 7.8e-11 7.5e-11 NA 5.5e-14
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.0750 0.0440 7.9e-03 0.045 0.034 0.034 NA 0.031 1.4e-03 4.6e-03 4.9e-03 NA 6.8e-03
11 TCGA Brain Lower Grade Glioma 0.0224 0.0130 4.9e-03 0.031 0.016 0.007 NA 0.023 1.7e-04 6.0e-03 4.2e-02 NA 1.1e-03
12 TCGA Lung Adenocarcinoma 0.0563 0.0254 7.9e-06 0.022 0.049 0.037 NA 0.043 1.3e-03 1.8e-06 3.7e-05 NA 9.0e-06
13 TCGA Lung Squamous Cell Carcinoma 0.0438 0.0226 1.6e-04 0.036 0.034 0.018 NA 0.024 5.0e-05 9.5e-05 3.4e-03 NA 8.1e-04
14 TCGA Ovarian Serous Cystadenocarcinoma 0.0320 0.0180 5.9e-03 0.011 0.025 0.011 NA 0.012 5.9e-02 8.1e-03 5.3e-02 NA 4.8e-02
15 TCGA Pheochromocytoma and Paraganglioma 0.1230 0.0690 6.1e-03 0.046 0.004 -0.005 NA 0.018 6.3e-03 2.1e-01 5.5e-01 NA 6.3e-02
16 TCGA Prostate Adenocarcinoma 0.1588 0.0661 2.0e-10 0.121 0.096 0.108 NA 0.119 1.2e-12 3.2e-10 2.2e-11 NA 2.2e-12
17 TCGA Stomach Adenocarcinoma 0.0910 0.0370 8.0e-07 0.083 0.078 0.064 NA 0.074 1.2e-06 2.6e-06 2.2e-05 NA 5.1e-06
18 TCGA Testicular Germ Cell Tumors 0.2610 0.1050 1.3e-03 0.066 0.048 0.126 NA 0.130 2.3e-03 8.8e-03 3.4e-05 NA 2.5e-05
19 TCGA Thyroid Carcinoma 0.1320 0.0590 1.5e-09 0.076 0.106 0.099 NA 0.119 6.7e-08 1.8e-10 7.1e-10 NA 1.3e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Bipolar Disorder (2018) 0.4 0.6 2.2 0.3 1.5 -0.6 -1.1 0.4 1.2 1.3 0.6 0.1 0.9 0.8 0.4 0.4 0.3 0.6 0.8 0.3 -0.8 0.2
Bipolar Disorder or Schizophrenia 1.0 2.4 6.0 -1.7 -0.4 2.2 0.3 -1.7 -0.8 0.1 -1.3 -2.1 -0.6 -1.2 -1.6 -1.1 -2.3 -1.5 -1.3 -2.4 -1.8 -2.0
Depressed Affect (Nagel 2018) 2.7 5.6 9.1 -2.0 -1.5 2.6 1.9 -3.0 -2.1 -0.8 -3.0 -2.3 -2.8 -2.8 -1.9 -2.3 -2.6 -2.8 -2.7 -2.5 -2.1 -2.4
Depression (Nagel 2018) 1.6 2.4 4.1 -1.5 -0.2 1.2 0.8 -1.8 -1.6 -1.6 -1.7 -1.6 -1.5 -1.7 -1.8 -1.7 -1.4 -1.9 -1.8 -0.9 -2.0 -1.5
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.5 -0.9 0.4 -0.0 -0.7 0.7 0.1 -0.6 0.9 -0.1 1.1 0.5 -0.1 1.0 -0.2 0.4 0.4 -0.6 1.2 -0.2
Neuroticism (Nagel 2018) 1.7 3.9 6.3 -1.4 -1.5 2.2 2.4 -2.3 -2.5 -1.2 -2.4 -1.5 -2.5 -2.4 -1.4 -1.3 -1.8 -2.4 -2.5 -2.0 -1.2 -1.6
Schizophrenia (2018) 2.7 5.5 12.4 -2.4 -1.7 3.5 1.3 -2.5 -2.0 -0.8 -2.1 -2.7 -1.5 -2.2 -2.4 -1.6 -3.2 -2.5 -2.3 -3.5 -1.6 -2.8
Schizophrenia vs Biploar Disorder 0.6 0.8 4.4 0.4 0.2 0.3 0.1 1.0 -0.6 -0.1 1.1 0.6 1.0 0.7 0.7 2.1 0.3 0.6 0.5 -0.8 2.1 0.6
Worry (Nagel 2018) 4.1 8.6 13.8 -2.1 -1.6 3.0 3.2 -3.3 -3.5 -2.3 -3.5 -2.6 -3.6 -3.7 -2.5 -2.1 -2.8 -3.5 -3.7 -2.9 -1.8 -2.7
Alzheimer’s Disease (in mother) 0.6 0.7 2.0 0.3 0.8 -0.3 -1.4 1.2 1.0 -0.1 1.0 0.5 0.9 1.0 0.3 0.5 1.1 1.1 1.0 1.2 0.2 0.6
Alzheimer’s Disease (in father) 0.4 0.5 3.1 0.2 1.8 -1.0 0.3 0.4 -0.5 -1.3 0.3 0.6 0.3 0.0 -0.1 0.1 0.3 0.1 0.0 0.5 1.2 0.5
Alzheimer’s Disease (including proxy) 0.6 0.8 3.8 0.2 1.9 -1.1 -1.1 0.8 0.6 -0.7 0.6 0.6 0.7 0.7 -0.1 0.1 1.3 0.7 0.7 1.8 0.1 0.8
Crohns Disease (2017) 0.6 1.2 6.3 -0.1 -2.5 1.7 0.6 -1.2 -0.3 0.2 -1.1 -0.7 -0.6 -1.0 0.2 -1.0 -1.4 -0.9 -0.8 -1.2 1.5 -1.1
Irritable Bowel Disease (IBD) 1.1 2.6 11.9 -0.8 -1.9 3.4 0.7 -1.8 -0.7 0.3 -1.5 -1.6 -1.0 -1.4 -0.6 -1.3 -2.3 -1.5 -1.3 -2.4 0.2 -1.9
Ulcerative Colitis (UC) 0.8 1.5 9.1 -0.6 -0.4 3.0 0.5 -1.3 -0.4 0.8 -1.0 -1.3 -0.7 -0.9 -0.5 -0.8 -1.7 -1.0 -0.8 -2.0 -0.7 -1.4
Major Depression (MDD) 0.3 0.3 0.8 0.4 -0.6 -0.9 -0.1 0.6 -0.1 -0.1 0.9 0.6 0.8 0.7 -0.0 0.8 0.6 0.4 0.6 0.3 -0.3 0.8
Reaction Time 0.3 0.6 2.8 0.9 -0.2 -0.1 1.2 -0.3 -0.7 0.2 -0.6 0.8 -1.7 -0.3 0.6 -0.1 1.1 -0.1 -0.3 0.7 -1.3 0.9
Verbal and Numeric Reasoning (VNR) 1.7 4.0 8.2 1.1 1.2 -1.6 -1.7 2.6 1.9 1.2 2.8 1.8 2.9 2.5 1.6 2.2 1.6 2.4 2.5 1.2 2.2 1.9
Breast Cancer 0.5 1.2 6.3 1.1 -1.1 -1.1 2.5 -0.4 -1.6 -0.1 -0.5 1.1 -1.1 -0.6 1.1 0.5 0.2 -0.4 -0.6 -0.5 2.0 0.8
Ovarian Cancer 0.8 1.1 4.0 -0.4 -0.8 1.0 2.0 -1.1 -1.5 -0.1 -1.2 -0.6 -1.2 -1.3 -0.5 -0.3 -1.0 -1.2 -1.4 -1.1 0.1 -0.7
Prostate Cancer 0.2 0.2 1.3 0.4 0.4 0.7 0.9 -0.1 0.4 1.1 -0.4 0.3 -0.5 -0.2 0.7 -0.1 -0.1 0.1 -0.1 0.0 0.6 0.1
Age at First Birth 0.7 1.0 3.9 0.6 0.3 -0.7 -2.0 0.6 1.9 1.0 0.7 0.2 1.5 0.8 0.5 0.0 0.7 0.7 0.9 1.6 0.6 0.3
Bipolar Disorder (2011) 0.7 0.7 3.4 0.3 1.1 -0.4 -1.1 -0.1 1.5 0.8 -0.0 -0.1 0.2 0.3 -0.0 -1.2 0.5 0.0 0.4 1.5 -1.8 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 1.9 1.4 0.8 -1.0 -0.8 1.0 0.9 0.4 1.1 0.9 1.2 1.0 1.0 0.9 0.9 0.9 1.0 1.0 1.4 0.8
Coronary Artery Disease (CAD) 1.9 2.2 5.7 1.1 1.1 -2.4 -1.7 1.4 1.7 0.8 1.6 1.1 1.7 1.7 1.2 0.9 1.7 1.5 1.7 2.0 0.4 1.4
Crohns Disease (2012) 0.3 0.5 3.7 0.4 -1.9 1.2 -0.0 -0.2 0.4 0.5 -0.2 0.0 0.2 -0.1 0.5 -0.3 -0.5 0.0 0.0 -0.4 1.6 -0.2
Mean Putamen Volume 1.0 1.1 2.5 0.6 1.2 -1.1 -0.5 1.0 0.6 0.9 1.3 1.0 1.3 1.2 1.3 1.4 0.7 1.0 1.2 0.1 1.6 1.0
Fasting Glucose 0.8 1.0 5.0 1.7 0.4 -0.7 2.2 -0.2 -1.9 -0.4 -0.3 0.9 -1.1 -0.5 0.6 0.5 0.4 -0.3 -0.5 -0.3 1.2 0.8
HbA1C 0.9 1.0 3.1 1.4 1.2 -1.8 1.4 0.2 -1.3 -1.3 0.1 1.1 -0.4 -0.1 0.6 0.5 0.9 -0.0 -0.2 0.5 1.5 1.0
HDL Cholesterol 0.4 0.7 2.5 -0.4 0.5 0.9 1.6 -0.9 -1.5 -0.2 -0.8 -0.4 -1.1 -0.8 -0.5 -0.3 -0.7 -0.9 -0.9 -1.2 -0.6 -0.4
LDL Cholesterol 1.3 2.1 6.7 -2.6 -1.8 1.1 -1.0 -1.2 -0.2 -1.8 -0.9 -1.9 -0.5 -1.1 -1.9 -1.5 -1.2 -1.3 -1.1 -0.6 -2.1 -1.7
Lupus 0.8 1.2 2.7 -0.7 -1.0 0.8 0.5 -1.2 -0.7 -1.0 -1.0 -1.4 -0.6 -1.3 -1.2 -1.6 -1.3 -1.4 -1.2 -0.4 -0.8 -1.4
Neuroticism (2016) 0.6 0.8 3.3 0.4 0.2 1.6 1.8 -1.2 -1.3 0.4 -1.0 0.1 -1.2 -0.9 0.4 -0.3 -0.4 -1.0 -0.9 -0.8 -0.5 -0.0
Primary Biliary Cirrhosis 1.3 1.9 12.1 0.5 0.3 -2.0 1.8 -0.6 -2.2 -3.5 -0.8 0.5 -1.5 -1.2 -0.5 -0.9 0.8 -1.1 -1.2 1.3 0.5 0.5
Rheumatoid Arthritis 0.8 1.1 4.2 2.1 0.3 -1.9 0.8 0.5 -0.7 -1.2 0.5 1.4 0.2 0.3 0.8 0.7 1.1 0.3 0.2 1.1 1.7 1.3
Schizophrenia (2014) 1.7 3.7 8.5 -1.2 -0.5 2.6 1.6 -2.2 -2.2 -1.0 -2.0 -2.0 -1.7 -2.1 -1.8 -1.1 -2.4 -2.2 -2.2 -2.9 -0.9 -2.0
Triglycerides 0.2 0.3 0.7 -0.8 -0.3 0.5 -0.1 -0.7 -0.2 -0.5 -0.5 -0.6 0.0 -0.5 -0.2 -0.8 -0.7 -0.7 -0.5 -0.3 0.7 -0.7
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.2 -0.2 -0.1 1.0 0.6 -0.5 -0.4 0.1 -0.7 -0.6 -0.9 -0.6 -0.1 -0.2 -0.9 -0.2 -0.4 -1.1 1.1 -0.7
Ulcerative Colitis 0.3 0.4 3.3 -0.4 -0.2 1.8 0.4 -0.4 -0.2 1.1 -0.2 -0.3 -0.2 -0.1 0.3 0.3 -0.7 -0.2 -0.1 -1.4 -0.1 -0.4
Blood Eosinophil Count 0.4 3.4 8.9 -3.0 -2.3 0.5 -3.0 -0.7 1.3 -1.7 -0.1 -2.6 1.0 -0.2 -2.6 -2.4 -1.9 -0.6 -0.1 -0.6 -2.3 -2.4
Blood Platelet Count 0.6 6.5 25.1 -1.6 -5.0 1.6 3.1 -2.9 -2.7 -1.6 -2.6 -1.5 -1.9 -2.9 -0.8 -2.1 -3.0 -2.9 -2.7 -2.6 2.2 -2.0
Blood Red Count 0.2 1.9 6.0 0.1 0.3 -1.0 -2.3 1.4 2.2 1.6 1.8 0.3 2.4 1.8 0.6 1.0 0.1 1.5 1.8 0.1 0.6 0.4
Blood White Count 0.4 3.0 12.0 -1.8 -3.5 0.5 -0.1 -1.7 -1.4 -2.8 -0.9 -1.7 -0.1 -1.2 -1.9 -2.1 -2.1 -1.8 -1.2 -1.4 0.3 -1.8
Heel T-Score 0.4 3.5 5.3 2.2 2.2 -1.6 -1.4 2.0 1.8 1.9 2.2 1.5 2.3 2.1 1.7 2.3 1.4 2.0 2.0 1.0 1.6 1.5
BMI 0.2 1.1 5.7 -0.8 -2.3 -2.0 -1.3 0.1 -0.2 -2.4 0.3 -0.3 0.1 0.2 -1.1 -1.1 0.4 0.0 0.2 0.8 -0.9 -0.1
Height 0.2 3.4 10.1 -1.0 1.3 0.6 -1.4 1.8 1.7 3.2 2.4 0.9 2.9 2.4 1.4 3.1 0.5 1.9 2.1 -0.8 0.4 1.1
Waist Hip Ratio (WHR) 0.3 1.4 5.7 2.4 1.1 -2.1 1.2 0.1 -0.9 -1.4 -0.1 1.5 -0.9 -0.1 0.7 0.0 1.6 0.1 -0.0 1.6 0.6 1.5
Systolic Blood Pressure 0.4 1.9 5.3 1.7 0.9 -1.4 0.6 1.5 0.0 0.9 1.5 1.9 1.2 1.2 1.4 2.3 1.5 1.2 1.1 0.9 1.6 1.9
Smoking Status 0.2 0.6 5.1 -0.5 0.6 -0.4 -0.2 -0.6 0.0 -1.3 -0.7 -0.1 -0.6 -0.5 -0.6 -2.2 -0.1 -0.4 -0.3 1.1 -0.0 -0.3
Allergy or Eczema 1.2 3.2 7.0 2.3 0.3 -0.9 0.5 2.1 0.5 1.9 1.7 2.4 0.7 1.6 2.3 2.6 2.2 2.0 1.6 1.1 2.0 2.4
Cardiovascular Disease 0.4 1.2 5.2 0.5 -0.4 -0.7 1.4 -0.8 -2.1 -2.3 -0.9 -0.1 -1.5 -1.3 -0.3 -0.4 -0.1 -1.1 -1.3 -0.3 1.1 -0.3
Hypothyroidism (self reported) 0.3 0.8 8.4 -0.4 -2.9 -0.1 -0.2 -0.6 -0.0 -1.0 -0.6 -0.3 -0.7 -0.4 -0.5 -1.4 -0.1 -0.4 -0.3 0.5 -0.6 -0.3
Respiratory disease 0.6 1.3 7.8 1.0 -0.1 -0.6 2.8 -0.1 -2.5 -0.9 -0.3 1.2 -1.3 -0.6 0.4 0.9 0.5 -0.5 -0.7 -0.6 1.2 1.1
Type 2 Diabetes (T2D) (2018) 1.3 2.5 17.0 3.0 0.7 -0.6 1.9 0.7 -0.8 0.5 0.6 2.0 0.2 0.3 2.1 1.5 0.9 0.6 0.4 0.3 4.1 1.6
Lung FEV1/FVC ratio 2.4 12.3 73.3 -0.9 0.6 1.4 -7.2 0.3 8.6 3.6 0.6 -1.1 3.1 2.1 0.1 -5.7 -0.3 2.0 3.1 4.7 -2.4 -1.1
Lung FVC 0.2 0.9 4.6 0.5 0.5 -0.8 -1.4 0.1 2.2 1.3 0.2 0.2 0.8 0.5 1.0 -1.1 0.3 0.6 0.9 1.6 0.6 0.0
Neuroticism 0.7 1.8 3.0 -1.3 -0.6 1.5 1.5 -1.4 -1.7 -0.8 -1.5 -1.0 -1.7 -1.4 -1.2 -0.7 -1.1 -1.5 -1.6 -1.5 -1.7 -0.9
Chronotype (morning person) 2.0 4.6 8.0 2.8 1.6 -2.5 0.1 2.1 1.3 2.3 1.9 2.8 1.4 1.9 2.5 2.6 2.5 2.1 1.9 2.0 1.4 2.8
Hair Pigment 0.0 0.5 1.4 0.6 -0.6 0.6 -0.3 -0.1 1.0 0.9 0.4 0.8 1.2 0.6 0.8 -0.8 0.3 0.2 0.7 1.2 0.6 0.7
Tanning 0.3 3.7 19.6 -1.9 2.0 -1.3 -4.4 0.8 2.6 -0.7 1.6 -1.4 2.7 1.6 -2.0 -1.2 -0.2 0.8 1.5 1.2 -3.0 -0.8
Hand grip strength (left) 0.1 0.2 1.4 0.6 -0.2 0.3 -0.0 -0.2 0.5 1.2 -0.1 0.0 0.2 0.0 0.8 0.1 -0.2 0.0 0.1 -0.2 0.6 -0.1
Number of treatments/medications taken 0.4 0.7 2.8 1.7 1.1 -0.2 1.6 -0.5 -1.0 0.2 -0.7 0.4 -1.2 -0.8 0.7 -0.2 0.0 -0.5 -0.6 -0.2 1.1 0.2
Average weekly spirits intake 1.4 1.7 4.9 -0.6 -0.5 -0.7 -2.2 1.3 2.1 1.6 1.6 0.4 2.0 1.8 0.2 0.3 0.6 1.5 1.8 1.1 -0.7 0.6
Sensitivity / hurt feelings 0.7 1.2 5.7 0.1 -0.7 0.2 2.0 -1.0 -2.4 -1.3 -0.8 -0.3 -1.0 -1.0 -1.0 0.2 -0.7 -1.3 -1.3 -1.4 -0.8 -0.2
Frequency of depressed mood in last 2 weeks 1.3 1.8 4.6 -1.2 0.3 0.5 0.7 -2.1 -1.0 -0.6 -1.6 -1.2 -1.3 -1.4 -1.2 -2.1 -1.2 -1.8 -1.4 -0.6 -2.1 -1.1
Hearing difficulty/problems: Yes 0.3 0.5 1.6 0.1 0.9 0.9 -0.5 0.8 0.3 0.7 0.9 0.5 0.7 0.8 0.7 1.3 0.3 0.8 0.7 -0.7 0.7 0.5
Relative age of first facial hair 2.3 4.8 11.4 1.9 1.3 -3.4 -1.3 2.3 1.8 1.1 2.3 2.5 2.1 2.3 1.8 1.7 2.7 2.3 2.3 2.9 1.0 2.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 2.7 -0.8 -1.6 -0.4 0.4 -0.2 -0.4 -0.5 -0.4 0.1 -0.9 -0.3 -0.2 -0.6 0.2 -0.1 -0.2 0.3 -0.5 0.1
Ever used hormone-replacement therapy (HRT) 3.0 3.8 11.4 1.8 3.4 -1.1 -0.8 1.9 1.4 1.9 1.9 2.1 1.5 2.0 2.3 2.1 2.2 2.0 2.0 1.7 1.4 2.1
Ever had hysterectomy (womb removed) 3.0 3.4 6.1 1.7 1.6 -1.4 -1.2 2.2 1.7 1.1 2.1 1.9 2.0 2.0 1.8 1.6 1.8 2.1 2.0 1.9 2.5 1.8
Systolic blood pressure, automated reading 0.6 1.9 4.9 1.2 1.3 -1.1 -0.1 1.5 0.6 1.2 1.6 1.6 1.3 1.5 1.5 2.2 1.5 1.4 1.3 0.8 1.0 1.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 2.3 0.8 0.8 -1.1 -0.1 0.4 0.1 -0.5 0.3 0.9 0.1 0.4 0.5 -0.0 1.1 0.4 0.4 1.5 0.2 1.0
Angina 0.3 0.4 1.6 0.9 0.6 -0.9 1.2 -0.3 -0.7 0.5 -0.3 0.8 -0.7 -0.2 0.8 0.1 0.7 -0.1 -0.2 0.5 0.3 0.7
Medication for hormone replacement therapy 4.1 4.5 8.0 1.9 1.7 -2.2 -0.9 2.3 1.4 2.3 2.1 2.4 1.6 2.2 2.6 2.7 2.8 2.3 2.1 2.2 1.3 2.4
Vitamin and mineral supplements 0.3 0.4 0.9 0.5 0.9 -0.8 -0.8 0.4 0.8 0.6 0.7 0.4 0.7 0.8 0.4 0.2 0.3 0.6 0.8 0.2 0.0 0.4
Supplements: Zinc 0.3 0.3 1.7 0.4 -1.0 -0.7 -0.8 0.5 0.5 -0.2 0.4 0.2 0.5 0.4 0.1 -0.1 0.7 0.4 0.4 1.3 0.0 0.2
Medication: Co-codamol 0.5 0.5 2.5 -0.3 0.7 0.2 -1.6 -0.1 1.1 -0.2 0.2 -0.3 0.5 0.3 -0.5 -1.4 0.1 0.1 0.5 1.1 -1.2 -0.2
Medication: Metformin 1.8 2.5 10.7 2.9 2.2 -0.5 2.9 0.4 -1.6 0.3 0.1 2.0 -0.6 -0.1 1.6 1.2 0.8 0.2 -0.1 0.0 3.3 1.7
Diabetes (father) 0.4 0.5 2.1 0.9 0.1 -1.5 -0.1 0.4 0.0 0.2 0.8 0.8 0.8 0.7 0.8 1.0 0.8 0.4 0.6 0.6 0.4 0.9
Diabetes (mother) 0.4 0.5 1.8 -1.2 -1.3 0.6 0.4 -0.0 -1.0 -1.3 -0.0 -0.4 -0.2 -0.2 -1.0 0.2 -0.5 -0.3 -0.4 -0.9 -0.4 -0.2
Severe depression (siblings) 1.1 1.3 5.0 0.7 -0.8 -1.1 2.2 -1.6 -1.3 -0.2 -1.5 0.7 -1.7 -1.2 0.6 -1.3 0.1 -1.2 -1.1 0.6 0.2 0.4
Pack years adult smoking proportion 2.5 3.9 7.2 1.0 1.1 -2.0 -2.6 2.6 2.3 1.0 2.6 1.3 2.7 2.5 1.1 1.9 1.6 2.5 2.4 1.5 1.2 1.5
Impedance of leg (right) 0.1 0.5 1.8 1.0 1.2 0.3 1.3 -0.9 -1.0 -0.4 -0.8 0.2 -0.9 -0.9 0.4 -0.2 -0.1 -0.9 -0.8 -0.1 0.3 0.1
Leg fat-free mass (left) 0.3 1.7 7.4 -1.3 -1.4 -0.3 -2.7 1.5 1.9 0.5 1.7 -0.3 2.1 1.6 -0.3 0.6 0.2 1.5 1.6 0.3 -0.2 -0.0
Trunk fat percentage 0.2 0.6 2.6 -0.9 -1.6 -0.0 -0.8 -0.3 0.0 -1.2 -0.4 -1.1 -0.3 -0.4 -1.0 -0.9 -0.4 -0.4 -0.4 -0.1 -1.0 -1.0
Hand grip strength (right) 0.1 0.2 1.5 0.2 -1.0 0.7 0.2 -0.5 0.3 1.2 -0.5 -0.3 -0.2 -0.3 0.5 -0.3 -0.4 -0.3 -0.2 -0.3 0.1 -0.4
Townsend deprivation index at recruitment 0.5 0.7 2.3 0.3 1.5 -0.8 0.2 -0.5 -0.6 -1.4 -0.2 0.3 -0.5 -0.1 -0.7 -1.5 0.5 -0.4 -0.1 1.2 -1.4 0.5
Current tobacco smoking 0.9 1.5 7.1 1.3 1.0 -2.3 -0.9 0.6 0.8 -1.1 0.7 1.3 0.8 0.8 0.4 -0.8 1.5 0.7 0.9 2.7 0.5 1.3
Average weekly fortified wine intake 0.2 0.3 1.6 -0.8 0.2 0.2 -0.1 0.1 -0.6 -1.3 0.0 -0.5 0.0 -0.2 -0.7 0.2 -0.5 -0.2 -0.3 -0.8 0.6 -0.5
Maternal smoking around birth 0.2 0.3 0.8 0.4 0.4 -0.6 0.8 -0.5 -0.5 -0.3 -0.6 0.0 -0.7 -0.5 -0.4 -0.5 0.0 -0.5 -0.5 0.3 -0.9 0.1
Fed-up feelings 1.3 2.4 5.7 0.0 -0.6 0.6 2.2 -2.0 -2.4 -1.5 -1.9 -0.7 -2.3 -1.9 -1.0 -1.5 -0.8 -2.0 -1.9 -0.9 -1.4 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 2.5 -0.6 0.7 -1.0 -0.7 0.1 -0.6 -1.6 0.4 -0.3 0.3 0.2 -0.8 -0.0 0.2 -0.1 0.0 0.2 -0.7 -0.1
Relative age voice broke 0.8 1.3 3.7 0.7 -0.6 -0.7 1.9 -1.1 -1.8 -1.9 -1.3 0.1 -1.4 -1.5 -0.7 -1.0 -0.2 -1.4 -1.5 0.4 0.1 0.0
Taking other prescription medications 1.1 1.7 6.6 0.1 -0.2 0.5 1.8 -1.7 -1.0 -0.0 -2.1 -0.4 -2.6 -1.7 -0.5 -2.2 -0.4 -1.4 -1.5 0.3 -1.4 -0.5
Age when periods started (menarche) 0.1 0.2 0.5 0.4 0.1 0.6 0.6 -0.5 -0.2 -0.4 -0.6 -0.2 -0.4 -0.5 -0.5 -0.7 -0.5 -0.5 -0.5 -0.1 0.0 -0.2
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 5.5 2.3 -0.5 -0.8 -0.1 1.5 1.0 1.6 1.3 1.9 1.0 1.3 1.7 1.6 1.7 1.5 1.4 1.5 1.2 1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 5.3 0.7 1.4 0.4 0.3 0.4 -0.3 0.7 0.4 -0.0 0.8 0.1 0.6 1.5 -0.6 0.2 0.1 -1.4 2.3 -0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 3.5 -0.4 0.5 -0.0 -1.8 0.9 1.7 1.9 1.2 0.5 1.3 1.5 1.2 0.7 0.8 1.3 1.5 0.6 0.0 0.6
Qualifications: CSEs or equivalent 1.5 2.0 5.4 -1.9 -1.2 0.4 -0.2 -1.7 -0.4 -1.5 -1.5 -1.7 -1.0 -1.3 -1.6 -2.3 -1.5 -1.5 -1.2 -0.7 -1.7 -1.6
Serious illness, injury or assault to yourself 1.3 1.6 3.7 -0.2 0.7 -0.6 -1.5 1.4 1.8 1.9 1.5 0.8 1.6 1.5 1.2 1.1 1.1 1.5 1.6 1.2 0.2 0.9
High blood pressure 0.8 2.1 7.5 1.6 -0.4 -0.2 2.7 -1.0 -2.6 -1.9 -1.4 0.2 -1.9 -1.7 -0.1 -0.3 -0.4 -1.3 -1.7 -0.7 2.0 -0.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 7.6 1.4 -0.3 -0.0 1.0 1.5 -0.6 1.2 1.1 1.4 0.3 0.9 1.3 2.8 0.9 1.1 0.7 -0.8 1.6 1.4
Multivitamins +/- minerals 0.3 0.3 1.2 -1.0 -0.7 0.8 -0.7 -0.0 0.7 0.1 -0.0 -0.4 0.3 0.1 -0.7 -0.9 -0.2 0.0 0.1 0.5 -1.1 -0.3
Stomach or abdominal pain in last month 0.5 0.6 2.8 0.6 0.3 -0.0 1.7 -1.0 -1.4 -0.1 -0.9 0.1 -1.2 -0.8 0.0 -0.3 -0.4 -0.9 -0.9 -0.8 -0.3 0.1
Supplements: Glucosamine 0.6 0.8 4.3 -0.9 0.3 0.5 -2.1 0.0 1.7 1.2 0.6 -0.7 1.4 0.7 0.2 -0.2 -0.4 0.3 0.8 0.1 -0.4 -0.6
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.7 -0.3 -0.6 0.1 0.6 -0.1 -0.2 0.5 0.4 -0.0 0.5 -0.2 0.4 0.6 0.5 0.4 0.4 -0.5 0.6
Medication: Atenolol 1.1 1.3 4.7 2.2 0.5 -1.8 0.5 0.8 -0.5 -1.3 0.5 1.4 0.0 0.3 0.7 0.4 1.5 0.5 0.3 1.8 1.9 1.3
Medication: Levothyroxine sodium 0.4 0.7 3.7 -1.2 -1.9 1.7 -0.6 -0.3 0.7 0.6 -0.4 -0.6 -0.4 -0.1 -0.3 -0.9 -0.6 0.0 0.0 -0.5 -0.9 -0.6
Sitting height 0.2 1.6 5.7 0.2 0.0 0.8 -1.6 1.6 1.4 1.3 1.7 -0.0 2.4 1.3 0.6 2.1 -0.2 1.2 1.2 -0.6 1.8 -0.1
Chronic bronchitis/emphysema (father) 1.0 1.2 3.1 1.6 1.4 -1.6 1.8 0.3 -1.6 -0.8 0.0 1.3 -0.7 -0.1 0.8 1.2 1.2 -0.0 -0.3 0.4 1.1 1.2
High blood pressure (mother) 0.2 0.3 1.9 0.1 -0.5 0.8 0.4 -0.4 -0.1 0.4 -0.2 -0.3 0.1 -0.4 0.5 0.2 -0.8 -0.4 -0.3 -1.0 1.4 -0.5
Body mass index (BMI) 0.1 0.6 2.6 -1.0 -1.6 -0.8 -1.3 0.1 0.1 -1.4 0.1 -0.7 0.0 0.1 -1.0 -0.8 -0.0 0.0 0.1 0.3 -0.7 -0.6
Impedance of leg (left) 0.1 0.4 1.5 1.0 1.2 -0.1 1.2 -0.8 -0.7 -0.1 -0.7 0.4 -0.6 -0.7 0.4 -0.3 0.0 -0.7 -0.6 0.1 0.3 0.2
Leg predicted mass (left) 0.3 1.8 7.7 -1.3 -1.4 -0.4 -2.8 1.6 1.9 0.5 1.8 -0.2 2.2 1.7 -0.3 0.7 0.3 1.5 1.6 0.3 -0.2 0.0
Trunk fat mass 0.1 0.5 2.8 -1.1 -1.7 -0.3 -1.4 0.2 0.6 -0.8 0.2 -0.9 0.3 0.2 -0.8 -0.4 -0.1 0.2 0.2 0.2 -0.8 -0.7
Waist circumference 0.1 0.5 3.1 -0.6 -1.6 -1.1 -0.3 -0.1 -0.6 -1.8 -0.1 -0.2 -0.6 -0.1 -0.8 -0.6 0.4 -0.2 -0.2 0.4 -0.9 -0.0
Number of incorrect matches in round 1.2 1.9 12.4 -1.6 -1.2 0.9 0.6 -1.2 -1.1 -0.9 -1.3 -1.1 -1.9 -1.0 -1.6 -1.2 -0.5 -1.1 -1.1 -0.8 -3.5 -0.8
Past tobacco smoking 0.1 0.2 1.5 1.2 -0.2 -1.2 0.1 -0.0 -0.1 -0.2 0.1 0.4 0.1 0.0 0.4 0.6 0.6 -0.1 -0.0 0.5 -0.3 0.5
Alcohol usually taken with meals 0.3 0.4 2.1 -1.0 0.2 1.1 0.1 0.5 -0.2 0.6 0.5 -0.3 0.5 0.3 -0.5 1.3 -0.6 0.3 0.1 -1.5 -0.3 -0.2
Nervous feelings 0.8 1.5 6.0 0.4 -1.1 0.2 2.5 -1.3 -2.0 -0.9 -1.6 -0.1 -2.0 -1.6 -0.3 -0.3 -0.2 -1.4 -1.6 -0.4 -0.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.8 -0.2 -1.1 -0.1 1.6 -1.0 -1.7 -1.1 -1.1 -0.1 -1.6 -1.1 -0.7 -0.9 -0.2 -1.1 -1.1 -0.2 -0.9 -0.1
Hearing difficulty/problems with background noise 0.5 0.9 4.0 1.1 1.4 0.7 0.5 0.8 -0.4 0.9 0.7 0.9 0.2 0.5 1.3 2.0 0.7 0.7 0.4 -0.5 1.4 0.8
Hair/balding pattern: Pattern 2 3.0 3.8 7.9 0.6 -1.6 2.2 2.8 -2.6 -1.9 -0.7 -2.7 -0.8 -2.5 -2.6 -0.2 -2.2 -1.8 -2.4 -2.3 -1.3 0.9 -1.3
Had menopause 1.0 1.3 4.7 1.1 2.0 -0.1 0.9 1.1 -0.5 1.0 0.8 1.4 -0.2 0.8 1.0 2.2 1.6 1.0 0.6 0.4 -0.3 1.6
Had other major operations 1.7 2.1 5.4 -0.2 1.7 -0.0 -2.2 2.3 1.7 0.4 2.1 0.3 2.2 1.8 -0.2 1.5 0.4 2.0 1.7 0.1 0.9 0.4
Forced vital capacity (FVC) 0.7 2.6 7.9 1.2 0.4 -1.2 -2.0 1.3 2.8 2.0 1.4 1.0 2.1 1.6 1.8 0.5 1.1 1.6 1.8 2.0 1.8 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.6 -0.7 -0.6 1.5 -0.5 -0.3 -0.1 -0.3 -0.2 -1.3 0.5 -0.5 -0.9 -0.1 -1.6 -0.5 -0.5 -1.5 0.7 -1.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 3.1 0.6 1.7 0.3 1.1 -0.7 -0.7 0.2 -0.7 0.2 -1.0 -0.6 0.5 -0.3 0.0 -0.5 -0.5 -0.2 0.1 0.1
Qualifications: None of the above 0.2 0.4 1.1 1.0 0.7 -1.0 0.5 -0.7 -0.1 0.0 -0.5 0.5 -0.6 -0.3 0.5 -0.9 0.5 -0.4 -0.2 1.0 -0.5 0.5
Financial difficulties in last 2 years 1.4 1.8 6.3 -1.0 -0.4 0.2 0.7 -1.7 -1.1 -1.8 -1.5 -1.0 -1.5 -1.4 -1.6 -2.5 -0.9 -1.5 -1.3 -0.0 -1.9 -1.0
Mouth/teeth dental problems 1.4 2.1 11.5 -1.6 0.5 0.7 -3.4 0.4 2.0 -0.1 1.0 -1.9 2.5 0.8 -1.3 -0.4 -1.7 0.4 0.8 -0.9 0.2 -1.9
Heart attack 0.5 0.6 2.2 -1.5 -0.4 -0.4 -1.2 -0.5 0.1 -1.0 -0.1 -1.1 0.3 -0.0 -1.0 -1.0 -0.6 -0.4 -0.0 -0.2 -1.1 -0.9
Allergy 0.5 1.1 4.6 -1.3 0.0 0.3 -1.9 -0.5 1.9 -0.1 -0.3 -1.1 0.5 -0.0 -0.9 -2.1 -0.6 -0.1 0.2 1.0 -1.6 -1.0
Pain all over the body in last month 3.0 3.2 7.5 0.8 1.6 -2.7 -1.3 2.0 1.1 0.7 2.4 1.7 2.2 2.2 1.0 2.5 1.9 1.8 2.0 1.3 0.1 2.0
Diabetes (self-reported) 0.7 1.1 6.5 1.7 0.0 -0.5 1.8 0.3 -1.6 -0.8 0.2 1.2 -0.3 -0.1 0.7 0.9 0.4 0.0 -0.1 -0.3 2.6 1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.0 -0.1 -0.4 0.8 0.9 0.2 -1.0 -0.3 0.1 0.3 -0.3 -0.0 -0.2 0.7 -0.1 0.0 -0.2 -0.8 0.4 0.3
Medication: Ramipril 0.4 0.5 3.5 1.9 0.7 -0.5 0.3 0.1 -0.1 0.3 0.2 0.8 0.2 0.1 0.9 0.3 0.7 0.1 0.2 0.9 0.8 0.7
Medication: Simvastatin 0.7 1.1 3.2 1.8 0.2 -1.7 0.6 0.7 -0.0 0.1 0.5 1.5 0.1 0.5 1.3 0.5 1.4 0.6 0.5 1.6 1.3 1.4
Fluid intelligence score 2.5 5.2 12.9 0.6 1.5 -1.6 -2.6 2.5 2.7 1.9 3.1 1.8 3.6 3.1 1.8 2.0 1.5 2.6 3.0 1.3 1.7 1.9
Illnesses of siblings 0.5 0.7 4.8 -0.7 -1.0 0.8 -0.4 -0.8 0.8 0.1 -0.9 -0.5 -0.6 -0.4 -0.6 -2.2 -0.4 -0.4 -0.2 0.7 -1.5 -0.5
Neuroticism score 0.9 1.9 4.9 -0.8 -0.5 1.2 1.9 -1.7 -2.2 -0.7 -1.4 -0.9 -1.7 -1.5 -0.9 -0.2 -1.1 -1.8 -1.7 -1.9 -1.5 -0.8
Weight 0.2 0.9 4.5 -1.4 -1.8 -0.4 -2.1 0.7 1.1 -0.3 0.8 -0.7 1.1 0.8 -0.7 -0.1 -0.0 0.7 0.8 0.2 -0.8 -0.5
Impedance of arm (right) 0.5 2.4 6.9 -0.9 -0.7 2.6 1.4 -1.8 -1.1 -0.9 -1.9 -1.5 -1.5 -1.9 -1.1 -1.4 -1.8 -1.8 -1.8 -1.4 -0.2 -1.7
Arm fat percentage (right) 0.4 1.7 6.7 -1.5 -2.6 0.6 -0.6 -0.8 -0.4 -1.9 -1.0 -1.7 -0.9 -1.0 -1.7 -1.6 -1.0 -0.9 -1.0 -0.4 -1.1 -1.6
Trunk fat-free mass 0.7 3.7 9.9 -0.5 -0.6 -1.2 -3.1 2.4 2.8 1.5 2.6 0.8 3.0 2.6 0.7 1.6 1.3 2.4 2.6 1.2 0.3 1.1
Hip circumference 0.2 0.9 4.6 -2.0 -2.1 0.2 -1.2 -0.2 0.1 -0.9 -0.1 -1.2 0.2 -0.1 -1.1 -0.6 -0.7 -0.3 -0.2 -0.5 -0.9 -1.0
Time employed in main current job 0.6 0.7 3.1 1.1 0.5 -0.2 0.5 0.3 0.4 1.8 0.4 1.2 0.0 0.7 1.4 0.7 1.0 0.7 0.7 0.6 -0.1 1.2
Alcohol intake versus 10 years previously 0.6 0.9 4.7 -0.8 -1.4 0.9 0.0 -1.3 -0.3 -0.9 -1.0 -0.9 -0.6 -0.9 -0.7 -2.2 -0.9 -1.0 -0.7 -0.0 -0.3 -1.0
Father’s age at death 0.5 0.7 1.9 1.4 0.1 -0.1 1.1 -1.0 -1.0 -0.9 -1.1 -0.2 -1.1 -1.1 -0.1 -0.8 -0.2 -1.0 -1.0 0.2 0.3 -0.4
Worrier / anxious feelings 4.3 8.1 16.2 -1.7 -2.2 2.5 3.8 -3.2 -4.0 -2.3 -3.2 -2.0 -3.6 -3.4 -2.0 -1.3 -2.5 -3.4 -3.6 -3.4 -1.5 -2.1
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 3.0 0.5 0.1 0.1 1.7 -0.9 -1.6 -0.8 -0.9 0.3 -1.3 -0.9 -0.0 -0.7 -0.0 -0.9 -0.9 -0.1 0.2 0.2
Falls in the last year 0.3 0.4 1.9 -1.2 0.4 -0.4 -1.4 0.7 0.5 -0.3 0.9 0.0 0.8 0.9 -0.2 0.0 0.3 0.7 0.9 0.2 -0.4 0.2
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 -0.9 -0.5 -0.5 -0.2 0.8 -0.1 -0.7 0.5 0.3 0.2 0.4 -0.3 1.0 0.8 0.5 0.2 0.5 -0.4 0.5
Number of live births 0.3 0.4 1.5 -0.4 -0.6 -0.5 0.6 -0.2 -0.5 -0.5 -0.8 -0.5 -1.2 -0.8 -0.6 -0.2 0.1 -0.4 -0.8 0.3 -0.8 -0.5
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 16.1 0.9 0.2 -0.6 -3.0 1.1 4.0 2.2 1.2 0.4 2.4 1.6 1.4 -0.8 0.6 1.6 2.0 2.4 1.2 0.3
Pulse rate 0.2 0.3 2.2 0.3 -0.1 0.1 1.5 -0.3 -0.9 0.2 -0.6 0.2 -1.1 -0.6 0.0 0.5 0.2 -0.4 -0.6 -0.3 -0.6 0.3
Happiness 6.2 7.5 13.4 -0.9 -1.2 2.2 2.9 -3.4 -3.2 -2.7 -3.6 -2.2 -3.7 -3.7 -1.9 -2.9 -2.4 -3.4 -3.5 -2.1 -0.8 -2.5
Noisy workplace 1.3 1.6 5.0 1.7 -0.5 0.4 2.2 -1.7 -1.6 -0.0 -1.7 -0.1 -1.7 -1.6 0.8 -0.4 -0.6 -1.5 -1.5 -0.8 1.2 -0.4
Qualifications: A levels/AS levels or equivalent 0.1 0.3 1.9 0.3 0.4 0.1 -0.8 0.4 0.9 0.1 0.3 -0.3 0.8 0.2 0.1 0.2 -0.3 0.3 0.3 0.1 1.4 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 3.1 0.7 1.8 -0.5 -0.6 0.8 0.8 0.0 0.5 0.4 0.6 0.5 0.1 0.2 0.6 0.7 0.5 1.0 0.3 0.4
Mouth/teeth dental problems: Dentures 0.6 1.1 2.6 0.1 -1.5 -0.3 0.2 1.0 0.8 1.3 0.6 1.5 -0.1 0.8 1.2 0.6 1.6 1.2 0.9 1.5 0.1 1.5
Asthma 1.0 1.9 9.3 -0.5 0.0 1.0 2.5 -1.1 -3.0 -1.2 -1.0 -0.4 -1.6 -1.3 -0.6 0.4 -1.1 -1.4 -1.5 -2.4 0.5 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 4.5 -1.2 -0.6 1.9 0.6 -1.0 -0.8 0.0 -0.8 -1.3 -0.7 -0.8 -1.0 -0.4 -1.6 -1.0 -0.9 -2.1 -1.2 -1.2
Medication: Cholesterol lowering 0.7 1.1 2.9 1.7 0.9 -1.5 0.2 1.4 0.3 -0.4 0.7 1.3 0.0 0.6 0.6 0.9 1.5 1.1 0.6 1.5 1.2 1.3
Depression (self-reported) 3.5 4.2 15.0 0.3 -0.8 1.5 3.9 -2.2 -2.8 -1.2 -2.8 -0.5 -3.4 -2.8 -1.1 -1.6 -1.0 -2.3 -2.7 -0.8 -0.8 -0.7
Medication: Lansoprazole 1.2 1.3 2.6 1.6 1.6 -1.6 -0.1 0.9 0.5 0.7 0.9 1.4 0.6 1.0 1.3 0.9 1.6 1.0 1.0 1.6 0.6 1.5
Prospective memory result 0.8 1.0 2.7 1.0 -1.0 -1.1 1.6 -1.0 -1.4 -0.8 -1.2 0.2 -1.5 -1.2 0.4 -0.6 0.3 -1.0 -1.2 0.5 0.7 0.0
Lung cancer (father) 1.3 1.5 2.9 0.8 0.6 -1.5 -1.2 1.5 0.8 0.2 1.7 1.1 1.7 1.6 0.7 1.6 1.4 1.3 1.4 1.2 0.2 1.3
Illnesses of mother 0.7 0.9 3.2 0.1 -0.2 -1.8 -1.4 0.8 1.0 -0.2 1.0 0.7 1.2 1.1 0.1 -0.2 0.9 0.9 1.1 1.4 -0.1 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.2 8.5 0.5 -0.2 0.4 -1.9 -0.3 2.9 1.6 -0.3 -0.5 0.8 0.1 0.6 -1.8 -0.4 0.3 0.6 1.4 0.5 -0.8
Pulse wave Arterial Stiffness index 0.3 0.4 1.3 0.3 -0.3 1.0 0.3 0.5 -0.4 -0.7 -0.0 -0.5 -0.1 -0.4 -0.4 1.2 -0.5 0.0 -0.5 -1.1 1.1 -0.5
Impedance of arm (left) 0.5 2.4 5.0 -0.5 -0.5 2.2 1.8 -1.9 -1.5 -0.5 -2.0 -1.3 -1.7 -2.1 -0.7 -1.1 -1.7 -1.9 -2.0 -1.5 -0.1 -1.6
Arm fat mass (right) 0.2 0.8 3.9 -1.3 -2.0 0.0 -1.4 0.0 0.4 -1.2 -0.1 -1.1 0.0 -0.1 -1.1 -0.8 -0.4 -0.1 -0.1 -0.0 -0.8 -1.0
Trunk predicted mass 0.6 3.6 9.4 -0.6 -0.7 -1.2 -3.1 2.4 2.7 1.5 2.6 0.8 2.9 2.6 0.7 1.6 1.2 2.4 2.5 1.2 0.2 1.1
Standing height 0.2 2.3 7.0 -1.0 -0.3 0.8 -2.4 1.4 2.5 2.4 1.8 0.0 2.6 1.8 0.6 1.5 0.1 1.5 1.8 0.0 -0.0 0.2
Length of working week for main job 2.1 2.3 4.5 1.1 0.7 -2.1 -0.8 1.7 0.8 0.2 1.8 1.9 1.5 1.7 1.3 1.2 1.9 1.6 1.7 1.9 1.2 2.0
Exposure to tobacco smoke at home 0.3 0.4 2.4 -0.4 -0.7 -1.2 0.1 0.5 -0.4 -0.2 0.2 0.1 -0.4 0.2 -0.4 0.7 0.7 0.3 0.1 0.0 -1.6 0.4
Breastfed as a baby 0.3 0.4 1.9 -0.8 1.4 1.1 -0.5 0.3 0.1 -0.0 0.1 -0.8 0.3 -0.1 -0.9 0.2 -0.7 0.1 -0.1 -0.7 -0.3 -0.7
Tense / ‘highly strung’ 1.1 1.7 6.9 0.5 -0.0 0.8 2.6 -1.7 -2.2 -0.3 -1.7 -0.4 -1.9 -1.7 -0.1 -0.4 -0.8 -1.7 -1.7 -1.3 -0.1 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 7.2 -1.2 -0.1 2.4 2.7 -2.5 -2.4 -0.6 -2.5 -1.2 -2.7 -2.3 -1.2 -1.6 -1.6 -2.3 -2.3 -1.7 -1.7 -1.3
Hair/balding pattern: Pattern 4 0.2 0.5 2.0 -0.3 -1.4 -0.8 -0.6 0.8 -0.1 -0.4 0.7 -0.3 0.6 0.3 -0.2 1.3 -0.2 0.4 0.2 -1.0 1.0 -0.3
Birth weight of first child 0.3 0.5 3.1 0.3 1.8 -0.2 -0.9 0.3 1.1 0.8 0.5 0.2 0.7 0.7 0.3 0.1 0.4 0.5 0.7 0.6 -0.6 0.3
Peak expiratory flow (PEF) 1.0 2.3 6.0 -2.0 -0.5 2.3 -1.8 -0.9 1.4 -0.2 -0.7 -2.3 0.7 -0.6 -1.8 -2.0 -2.5 -0.7 -0.4 -1.1 -0.5 -2.4
Pulse wave reflection index 0.7 0.8 2.7 -0.1 -0.8 1.0 1.0 -0.8 -1.1 -0.7 -0.8 -0.8 -0.8 -1.0 -0.8 -0.1 -1.2 -1.0 -1.1 -1.6 -0.4 -0.8
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.2 1.0 1.4 -0.5 1.0 0.8 0.0 1.2 0.4 1.5 -0.2 0.5 1.4 1.1 1.0 0.8 0.5 0.4 1.3 1.4
Loud music exposure frequency 0.9 1.0 2.3 1.0 0.2 -1.0 0.3 0.8 0.5 1.5 0.8 1.5 0.5 1.0 1.5 0.7 1.0 1.0 1.0 0.7 1.1 1.4
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 1.3 0.3 0.2 -0.1 0.4 -0.2 -0.3 -0.4 -0.1 -0.1 0.1 -0.3 0.0 0.1 -0.5 -0.3 -0.3 -0.6 1.1 -0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.3 1.1 0.0 -0.5 1.5 0.3 -0.9 0.5 0.1 1.0 -0.6 0.1 0.7 1.2 0.7 0.2 -0.0 -0.3 0.1 1.0
Blood clot in the leg (DVT) 0.4 0.5 1.7 0.9 -1.3 -1.1 0.3 0.2 0.1 -0.1 0.2 0.8 0.2 0.1 0.8 0.3 0.8 0.2 0.2 1.1 0.9 0.7
Medication: Paracetamol 0.5 0.9 2.3 0.3 0.8 -0.1 1.1 -1.5 -1.5 -1.3 -0.9 -0.4 -0.8 -1.0 -0.4 -1.0 -0.9 -1.4 -1.0 -1.0 0.0 -0.5
Headache pain in last month 2.9 5.0 10.3 -1.1 -2.2 3.2 2.3 -2.5 -1.8 -1.0 -2.8 -1.9 -2.6 -2.6 -1.9 -2.6 -2.5 -2.4 -2.5 -2.0 -1.2 -2.1
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 5.0 -1.6 -1.2 1.3 -0.6 -0.9 0.0 -0.1 -0.5 -1.3 -0.1 -0.4 -1.2 -0.9 -1.0 -0.8 -0.5 -0.7 -2.2 -1.0
Glaucoma (self-reported) 1.6 1.8 4.9 1.5 1.5 -2.2 0.4 1.5 0.3 0.5 0.8 1.8 0.2 0.7 1.5 1.9 1.8 1.2 0.7 1.4 1.8 1.6
Gout (self-reported) 0.8 1.0 6.0 0.3 0.0 0.6 2.4 -0.8 -1.9 -0.2 -1.1 0.2 -1.7 -1.1 -0.1 0.0 -0.4 -0.9 -1.2 -1.0 0.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 6.4 -0.4 -2.5 0.0 -0.2 -0.2 0.2 -0.3 -0.4 -0.0 -0.6 -0.1 -0.2 -1.0 0.1 -0.0 -0.0 0.5 -0.5 -0.0
Medication: Amlodipine 0.3 0.4 3.1 0.5 0.3 -0.3 0.0 -0.1 -0.6 -1.8 -0.1 -0.4 0.2 -0.5 -0.8 -0.4 -0.6 -0.4 -0.5 -0.2 1.3 -0.5
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.3 0.5 -1.5 0.8 1.1 -0.5 -0.9 -0.0 -0.7 -0.2 -0.7 -0.8 -0.0 0.1 -0.6 -0.6 -0.8 -0.9 0.6 -0.4
Birth weight 3.3 7.2 27.6 -1.2 0.9 -1.7 -5.3 3.0 3.9 1.7 3.6 0.3 4.5 3.6 0.2 1.7 1.3 3.1 3.5 1.6 -0.8 0.8
Chronic bronchitis/emphysema (mother) 0.9 1.1 2.2 -0.6 -0.9 0.9 0.8 -1.3 -0.7 -0.6 -1.4 -0.9 -1.5 -1.3 -0.9 -1.3 -0.8 -1.2 -1.2 -0.5 -1.4 -0.9
High blood pressure (siblings) 0.1 0.2 0.8 0.0 -0.1 0.3 0.0 0.4 -0.3 -0.5 0.2 -0.4 0.4 -0.1 -0.4 0.9 -0.5 0.0 -0.2 -0.9 0.9 -0.5
Forced vital capacity (FVC), Best measure 0.2 0.6 2.7 0.9 -0.1 -0.1 -1.0 -0.0 1.7 1.1 -0.0 -0.1 0.8 0.1 0.9 -0.6 -0.1 0.2 0.4 0.9 1.3 -0.4
Body fat percentage 0.3 1.0 3.8 -0.9 -2.0 -0.1 -0.3 -0.8 -0.5 -1.6 -0.9 -1.2 -0.9 -0.9 -1.2 -1.3 -0.5 -0.8 -0.8 -0.1 -1.0 -1.1
Leg fat percentage (right) 0.2 0.6 3.8 -0.1 -2.0 -0.8 0.0 -0.5 -0.6 -1.3 -0.7 -0.4 -1.0 -0.7 -0.4 -0.9 0.1 -0.6 -0.6 0.3 -0.3 -0.4
Arm fat-free mass (right) 0.7 3.4 8.0 -0.3 -0.3 -1.5 -2.8 2.3 2.3 1.6 2.6 0.9 2.8 2.6 0.8 1.9 1.3 2.3 2.4 0.9 0.0 1.1
Exposure to tobacco smoke outside home 0.1 0.2 0.6 -0.5 -0.8 -0.8 0.1 0.4 -0.2 -0.4 0.1 0.1 -0.4 0.1 -0.4 0.2 0.4 0.3 0.0 0.2 -0.8 0.3
Comparative body size at age 10 1.0 2.6 12.0 -3.5 -1.7 -0.1 -2.9 0.1 1.0 -1.1 0.4 -2.3 1.2 0.2 -2.3 -0.9 -1.5 -0.1 0.1 -1.0 -1.9 -2.0
Number of full brothers 1.1 1.4 3.3 -0.8 -0.7 -0.0 1.0 -1.5 -1.8 -1.3 -1.3 -1.2 -1.4 -1.4 -1.0 -0.8 -0.9 -1.5 -1.5 -1.1 -1.1 -1.2
Worry too long after embarrassment 0.2 0.3 2.5 -0.6 -1.6 0.6 0.3 -0.2 -0.7 -0.7 -0.1 -0.3 -0.1 -0.3 -0.4 0.2 -0.4 -0.4 -0.4 -0.7 0.2 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 6.6 8.6 15.9 -1.6 -0.3 3.0 3.6 -3.6 -3.8 -2.0 -3.7 -2.1 -4.0 -3.6 -2.1 -2.6 -2.7 -3.6 -3.6 -3.0 -1.7 -2.3
Wheeze or whistling in the chest in last year 0.9 1.6 7.7 -0.0 -0.4 0.7 2.6 -0.7 -2.8 -1.1 -0.9 0.0 -1.7 -1.3 -0.1 0.6 -0.7 -1.1 -1.4 -1.9 1.3 -0.2
Number of children fathered 0.4 0.5 2.2 -0.3 -1.5 -0.8 0.4 0.8 -1.0 -1.5 0.4 0.5 -0.4 0.2 -0.3 0.8 0.8 0.4 -0.0 0.3 0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 3.3 0.7 1.8 -0.6 1.2 -0.6 -0.6 0.6 -0.5 0.6 -0.8 -0.4 0.8 -0.1 0.3 -0.4 -0.4 0.2 -0.1 0.5
Age at first live birth 0.2 0.4 2.6 -0.8 -0.3 1.6 -0.7 -0.3 0.8 0.7 -0.3 -0.7 0.0 -0.2 0.0 -0.6 -0.6 -0.1 -0.0 -0.3 0.1 -0.8
Pulse wave peak to peak time 0.4 0.5 1.7 -0.4 0.4 -1.1 -0.7 -0.2 0.8 0.8 0.3 0.5 0.5 0.6 0.5 -1.0 0.6 0.2 0.7 1.3 -0.9 0.6
Health satisfaction 0.6 0.8 3.3 0.6 0.9 -0.2 1.8 -1.0 -1.3 -0.8 -1.1 0.4 -1.5 -1.0 0.3 -0.8 -0.1 -0.9 -0.9 -0.1 0.7 0.2
Shortness of breath walking on level ground 1.0 1.1 4.7 0.4 -0.9 0.4 2.2 -1.1 -1.7 -0.6 -1.4 0.3 -2.0 -1.3 0.3 -0.6 -0.0 -1.0 -1.2 -0.4 0.5 0.1
Qualifications: College or University degree 0.2 0.8 3.3 -0.5 -0.3 -0.3 -0.3 1.4 -0.2 -0.5 1.4 0.7 1.0 1.0 0.2 1.8 0.6 1.0 0.8 -0.4 1.2 0.8
Eye problems/disorders: None of the above 0.3 0.4 1.7 0.2 -0.3 1.1 -0.7 0.2 1.3 1.1 0.2 0.2 0.6 0.5 0.8 -0.3 -0.2 0.5 0.6 0.1 0.9 -0.0
Mouth/teeth dental problems: Loose teeth 2.1 2.5 7.2 -0.3 -1.5 0.7 2.1 -1.8 -1.6 -2.0 -2.3 -0.4 -2.7 -2.1 -1.0 -2.3 -0.5 -1.7 -1.9 0.3 -0.8 -0.6
Emphysema/chronic bronchitis 0.5 0.6 2.5 -0.7 -0.3 0.5 1.6 -0.4 -1.6 -0.8 -0.6 -0.1 -1.0 -0.8 -0.6 0.2 -0.3 -0.7 -0.9 -0.7 0.0 -0.1
Medication for pain relief, constipation, heartburn 1.4 2.5 5.3 0.3 -0.2 -0.8 -1.7 1.9 2.3 2.0 1.7 1.3 1.7 1.9 1.5 1.3 1.5 2.0 2.0 1.6 0.8 1.3
Neck or shoulder pain in last month 0.4 0.6 1.6 1.0 0.4 -0.8 -0.3 0.4 0.6 1.2 0.6 0.9 0.6 0.7 1.3 0.3 0.9 0.6 0.8 1.0 0.7 0.8
Medication: Blood pressure 0.3 0.6 5.8 1.5 0.7 -0.1 0.9 0.2 -0.6 -0.2 -0.0 0.5 -0.2 -0.2 0.7 0.5 -0.0 0.1 -0.2 -0.3 2.4 0.2
Angina (self-reported) 0.2 0.3 1.6 0.4 0.1 -0.5 1.3 -0.6 -1.0 0.0 -0.6 0.3 -1.0 -0.5 0.3 -0.2 0.2 -0.5 -0.5 0.1 -0.1 0.2
Migraine (self-reported) 0.6 0.7 1.6 -1.1 -0.1 0.7 -0.3 -0.8 -0.3 -0.8 -0.5 -1.2 -0.1 -0.6 -1.3 -0.9 -1.3 -0.8 -0.6 -1.0 -0.8 -1.2
Medication: Ibuprofen 1.2 1.5 3.7 -1.4 -1.3 1.8 0.2 -1.0 -0.6 -0.3 -0.9 -1.5 -0.7 -0.8 -1.5 -0.7 -1.5 -1.0 -0.9 -1.8 -1.9 -1.4
Medication: Allopurinol 1.2 1.6 4.8 0.0 -0.4 1.2 2.2 -1.4 -1.7 -0.5 -1.8 -0.6 -2.1 -1.7 -0.6 -1.0 -1.0 -1.4 -1.7 -1.0 -0.2 -0.8
Medication: Omeprazole 0.4 0.5 1.3 0.0 -0.8 -0.8 1.0 -1.0 -0.6 -0.3 -0.9 0.2 -1.0 -0.8 0.4 -1.2 0.3 -0.8 -0.6 0.9 -0.2 0.1
Medication: Seretide 50 evohaler 0.7 0.8 4.5 0.6 -0.3 -0.1 2.1 -0.9 -1.7 0.1 -0.7 0.5 -1.0 -0.8 0.8 0.2 -0.2 -0.9 -0.8 -0.9 1.4 0.3
Mean time to correctly identify matches 0.4 0.7 4.1 0.4 -0.0 0.2 1.6 -0.4 -1.0 0.5 -0.9 0.5 -2.0 -0.6 0.4 0.2 0.8 -0.3 -0.6 0.1 -1.5 0.6
Heart disease (mother) 0.1 0.1 1.3 0.1 1.1 0.2 -0.3 -0.2 0.0 0.3 0.2 -0.1 0.5 0.2 0.5 -0.0 -0.3 -0.1 0.2 -0.3 0.7 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 6.3 0.5 0.3 -1.0 2.0 0.7 -2.1 -0.3 0.4 0.9 -0.6 -0.0 0.3 2.5 0.9 0.1 -0.4 -0.8 0.3 1.1
Whole body fat mass 0.1 0.5 2.9 -1.0 -1.7 -0.5 -1.1 0.0 0.2 -1.0 -0.0 -0.8 0.0 -0.0 -0.9 -0.5 -0.1 -0.1 -0.0 0.1 -0.9 -0.7
Leg fat mass (right) 0.1 0.4 2.0 -0.4 -1.4 -0.9 -1.3 0.6 0.5 -0.7 0.6 -0.2 0.5 0.5 -0.3 0.1 0.4 0.5 0.5 0.5 -0.2 -0.1
Arm predicted mass (right) 0.7 3.6 8.7 -0.4 -0.4 -1.5 -3.0 2.3 2.6 1.8 2.6 0.8 2.8 2.6 0.8 1.8 1.3 2.4 2.5 1.0 0.0 1.1
Pulse rate, automated reading 0.3 1.0 3.9 1.4 0.1 -0.4 1.9 0.2 -0.9 1.2 0.1 1.1 -0.4 -0.0 1.4 2.0 0.6 0.1 -0.1 -0.6 1.1 1.1
Alcohol intake frequency. 1.9 4.4 10.4 -1.0 -1.6 1.0 1.8 -2.7 -1.8 -1.6 -2.8 -1.8 -2.7 -2.6 -1.9 -3.2 -1.8 -2.5 -2.4 -0.8 -1.9 -1.9
Comparative height size at age 10 0.3 1.6 5.7 -2.0 -1.1 2.1 -2.4 0.1 2.0 1.2 0.3 -1.5 1.2 0.4 -0.6 -0.4 -1.0 0.3 0.5 -0.6 -1.1 -1.4
Number of full sisters 0.3 0.4 1.5 0.1 0.1 0.4 0.2 -0.9 -0.5 -1.2 -0.8 -0.4 -0.7 -0.8 -0.6 -1.1 -0.3 -0.8 -0.7 0.1 -0.5 -0.4
Suffer from ‘nerves’ 0.3 0.4 2.7 0.5 0.1 -0.1 1.6 -0.3 -1.1 0.3 -0.4 0.6 -0.8 -0.5 0.6 0.7 0.3 -0.4 -0.5 -0.4 0.4 0.6
Overall health rating 0.8 1.6 5.4 -0.4 -0.4 0.4 2.2 -1.5 -2.3 -1.8 -1.5 0.0 -2.0 -1.5 -0.4 -1.3 -0.4 -1.5 -1.4 -0.6 -0.0 -0.1
Chest pain or discomfort 0.4 0.6 2.8 0.8 0.6 -0.8 1.7 -0.3 -1.3 -0.2 -0.4 0.8 -0.9 -0.4 0.9 0.4 0.6 -0.3 -0.4 0.1 1.0 0.7
Had major operations 0.8 1.0 2.2 0.2 0.7 -0.8 -0.9 1.5 0.9 1.1 1.3 0.7 0.8 1.3 0.4 1.3 1.0 1.4 1.2 0.5 -0.5 0.9
Age at last live birth 0.6 0.8 2.6 -1.2 -0.8 1.6 -0.7 -0.7 0.8 0.4 -0.7 -1.2 -0.3 -0.5 -0.7 -1.4 -1.0 -0.4 -0.4 -0.5 -1.1 -1.3
Family relationship satisfaction 6.8 8.3 14.8 -1.1 -0.4 0.6 3.1 -3.6 -3.8 -3.6 -3.7 -2.3 -3.7 -3.8 -2.5 -2.8 -2.3 -3.8 -3.8 -1.8 -1.5 -2.4
Leg pain on walking 0.2 0.3 3.3 0.4 1.8 -0.3 -0.0 -0.3 -0.3 -0.3 -0.3 -0.0 -0.5 -0.1 -0.1 -0.7 0.2 -0.2 -0.1 0.2 -0.5 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 1.2 -0.1 0.9 -0.6 -0.3 0.2 -0.2 -1.1 0.3 -0.2 0.4 0.1 -0.6 0.1 0.1 0.0 0.0 0.2 -0.3 -0.1
Commuting to job workplace: Car/motor vehicle 2.6 2.9 6.0 1.1 2.4 -1.0 -2.2 1.8 2.0 1.4 2.2 1.1 2.4 2.2 1.5 1.6 1.2 1.9 2.2 0.9 1.1 1.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 2.0 -0.5 -0.6 0.4 0.3 -0.3 -0.8 -0.8 -0.2 -0.5 -0.2 -0.3 -0.3 0.3 -0.7 -0.5 -0.4 -1.4 0.4 -0.5
Medication: Aspirin 0.8 1.1 2.7 -0.2 -0.7 0.4 0.8 -0.9 -1.3 -1.7 -1.1 -1.0 -1.2 -1.2 -1.4 -1.0 -0.9 -1.1 -1.2 -0.9 -0.7 -1.0
Supplements: Vitamin C 0.8 0.9 3.6 0.1 -1.9 -0.4 0.7 -1.1 -0.9 -1.2 -1.2 -0.6 -1.1 -1.3 -0.5 -1.1 -0.3 -1.2 -1.2 0.3 -0.2 -0.7
Knee pain experienced in last month 0.3 0.4 3.1 -0.5 0.3 0.2 0.2 -0.6 -0.4 -0.4 -0.6 -0.3 -1.0 -0.4 -0.5 -0.9 0.2 -0.5 -0.4 0.3 -1.8 -0.2
Hypertension (Self-reported) 0.9 2.5 8.1 1.1 -0.4 0.3 2.8 -1.3 -2.8 -2.1 -1.7 -0.1 -2.3 -2.0 -0.5 -0.6 -0.6 -1.6 -2.0 -1.0 1.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.9 2.1 0.2 -1.0 0.1 0.9 -1.0 -1.0 -1.1 -1.2 -0.5 -1.4 -1.1 -0.9 -1.2 -0.3 -1.0 -1.1 0.1 -1.0 -0.5
Illnesses of father: Heart disease 0.7 1.0 2.2 1.1 -0.5 -0.3 -0.8 1.3 1.2 0.7 1.0 1.0 0.8 1.0 1.1 1.0 1.0 1.2 1.1 0.9 1.5 0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.9 -0.4 -1.0 0.0 0.2 -0.2 -0.5 -0.3 -0.3 -0.2 -0.4 -0.4 0.1 0.4 -0.0 -0.3 -0.4 -0.4 0.1 -0.2
Smoking status: Previous 0.2 0.3 2.3 -1.5 -0.4 1.1 0.3 0.0 -0.4 0.0 -0.1 -0.5 -0.3 -0.2 -0.5 -0.1 -0.7 -0.0 -0.2 -1.0 0.3 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.2 -0.8 -0.9 0.3 -1.3 0.9 1.1 0.5 1.1 0.0 1.5 1.0 -0.1 0.7 0.1 0.8 1.0 0.2 -0.5 0.3
Whole body fat-free mass 0.5 3.1 10.2 -1.0 -0.9 -1.0 -3.2 2.2 2.6 1.2 2.4 0.4 2.8 2.4 0.3 1.3 0.9 2.2 2.3 0.9 -0.1 0.7
Leg fat-free mass (right) 0.4 2.1 8.6 -1.3 -1.3 -0.5 -2.9 1.6 2.3 0.8 1.9 -0.2 2.4 1.9 -0.2 0.7 0.2 1.6 1.8 0.4 -0.2 0.0
Arm fat percentage (left) 0.3 1.2 5.4 -1.1 -2.3 0.2 -0.5 -0.7 -0.4 -1.6 -0.9 -1.4 -0.9 -0.9 -1.3 -1.2 -0.7 -0.7 -0.8 -0.3 -0.9 -1.3
Average weekly red wine intake 0.4 0.6 1.8 -0.2 0.2 -0.7 -1.0 1.3 0.6 -0.1 1.1 0.2 1.1 0.9 -0.5 1.2 0.5 1.0 0.7 0.4 -0.5 0.4
Handedness (chirality/laterality): Left-handed 1.3 1.6 7.7 1.5 0.4 0.3 2.8 -1.0 -2.2 -0.5 -1.3 0.6 -2.2 -1.3 0.8 0.2 0.2 -1.0 -1.3 -0.5 1.1 0.3
Mood swings 2.3 4.2 6.7 -1.8 -1.6 2.2 1.2 -2.6 -1.8 -0.7 -2.2 -2.2 -1.9 -2.1 -1.8 -1.7 -2.4 -2.4 -2.1 -2.5 -2.3 -2.2
Loneliness, isolation 1.5 2.0 4.6 -0.2 -0.0 1.4 1.8 -1.8 -2.1 -1.1 -1.6 -1.1 -1.5 -1.7 -1.0 -0.8 -1.4 -1.9 -1.8 -1.6 -0.9 -1.1
Long-standing illness, disability or infirmity 0.7 1.0 3.1 -0.6 -0.2 0.3 0.7 -0.9 -1.1 -1.8 -1.1 -0.9 -1.3 -1.2 -1.4 -1.3 -0.7 -1.0 -1.2 -0.4 -0.8 -0.8
Ever had bowel cancer screening 3.0 3.5 10.4 0.1 0.4 1.0 3.2 -2.1 -3.0 -1.4 -2.3 -0.7 -3.0 -2.2 -1.3 -1.0 -0.8 -2.2 -2.4 -1.2 -2.2 -0.6
Diabetes diagnosed by doctor 1.2 1.9 6.6 2.4 1.2 -0.7 2.1 0.9 -1.2 0.3 0.6 2.1 -0.2 0.4 1.6 1.5 1.2 0.7 0.4 0.3 2.6 1.9
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.6 6.0 1.2 1.4 -2.4 -1.3 1.6 1.5 0.9 1.8 1.6 2.0 1.7 1.4 1.2 1.7 1.5 1.7 2.2 1.3 1.6
Friendships satisfaction 3.3 4.0 11.4 -1.7 -0.8 0.3 1.0 -2.1 -2.4 -3.4 -2.1 -1.9 -2.3 -2.2 -2.4 -1.8 -1.4 -2.3 -2.3 -1.3 -2.2 -1.8
Qualifications: nursing, teaching 0.2 0.4 2.1 0.4 0.3 -0.4 -0.5 0.7 0.7 0.5 0.6 0.3 0.6 0.5 0.8 0.9 0.2 0.6 0.5 0.0 1.5 0.1
Commuting to job workplace: Walk 0.7 0.8 4.0 0.5 -0.8 0.4 2.0 -0.5 -0.9 0.4 -1.1 0.3 -1.6 -1.1 0.7 0.1 -0.2 -0.5 -0.9 -0.7 1.3 -0.0
Eye problems/disorders: Cataract 0.6 0.7 2.0 -0.6 0.1 -0.4 0.4 -0.7 -1.1 -1.4 -0.7 -0.9 -0.7 -0.9 -1.2 -0.3 -0.6 -1.0 -1.0 -0.6 -1.0 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 16.5 1.8 0.4 -0.8 4.1 -0.9 -2.7 0.4 -1.4 1.5 -2.8 -1.3 1.4 0.8 1.1 -0.9 -1.4 -0.0 0.4 1.3
Medication for cholesterol 1.0 1.5 3.6 -1.6 -0.4 1.4 0.0 -0.9 -0.4 -1.1 -0.9 -1.7 -0.4 -1.1 -1.7 -1.0 -1.9 -1.1 -1.1 -1.6 -0.7 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 5.7 -1.5 -0.8 1.0 1.5 -1.8 -2.4 -2.1 -1.7 -1.5 -1.8 -1.8 -2.1 -1.6 -1.4 -1.9 -1.9 -1.4 -1.8 -1.4
Back pain experienced in last month 1.4 2.1 6.0 -1.2 -0.5 1.8 0.8 -2.2 -0.8 -0.3 -1.9 -1.4 -1.6 -1.7 -0.5 -2.4 -1.6 -1.8 -1.5 -1.0 -0.4 -1.6
Mineral and other dietary supplements 1.1 1.5 2.9 1.3 1.1 -0.5 -0.7 1.6 1.2 1.1 1.2 1.4 0.6 1.4 1.3 1.1 1.4 1.7 1.5 0.8 0.9 1.4
Breast cancer (self-reported) 1.7 2.0 6.7 -2.3 -1.1 1.7 -2.6 1.5 1.6 0.3 1.4 -1.3 1.8 1.2 -1.6 0.8 -0.7 1.2 1.0 -0.7 -1.3 -0.9
Asthma (self-reported) 0.9 1.8 8.8 -0.2 0.0 0.8 2.6 -1.0 -3.0 -1.1 -1.0 -0.2 -1.6 -1.3 -0.5 0.4 -1.0 -1.3 -1.5 -2.2 0.8 -0.3
Osteoporosis (self-reported) 0.8 0.9 3.3 1.1 1.8 -1.1 -0.3 0.2 0.9 1.2 0.4 1.0 0.7 0.5 1.3 -0.1 0.9 0.5 0.7 1.7 1.0 0.9
Osteoarthritis (self-reported) 0.2 0.2 1.6 0.0 1.3 -1.0 -0.1 0.1 -0.4 -0.1 0.1 -0.1 -0.1 -0.0 -0.2 0.7 0.4 -0.1 -0.2 0.1 -1.0 0.1
Medication: Aspirin 0.6 0.8 2.4 -0.1 -0.4 0.1 0.8 -0.8 -1.3 -1.6 -0.9 -0.8 -1.1 -1.0 -1.1 -1.0 -0.7 -0.9 -1.0 -0.6 -0.4 -0.8
Medication: Gliclazide 0.8 0.9 5.7 2.1 1.2 0.5 1.2 0.3 -0.9 -0.2 0.2 0.9 0.0 0.0 0.6 0.6 0.1 0.2 0.0 -0.3 2.4 0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 1.2 -1.0 -1.0 0.8 -0.3 -0.3 0.3 0.5 -0.2 -0.7 0.0 -0.1 -0.6 -0.4 -0.6 -0.1 -0.1 -0.6 -1.1 -0.6
Smoking status: Current 0.7 1.1 5.9 1.2 0.9 -2.0 -0.6 0.3 0.6 -1.0 0.4 1.1 0.4 0.5 0.4 -1.1 1.3 0.4 0.6 2.4 0.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 5.8 1.2 -0.2 -0.6 -1.2 -0.1 2.4 1.9 -0.2 0.3 0.5 0.3 1.3 -1.2 0.4 0.5 0.7 2.0 0.4 0.0
Whole body water mass 0.5 3.1 10.1 -1.0 -1.0 -1.0 -3.2 2.1 2.6 1.2 2.4 0.4 2.8 2.4 0.3 1.3 0.9 2.1 2.3 0.9 -0.0 0.7
Leg predicted mass (right) 0.4 2.2 8.8 -1.3 -1.3 -0.5 -3.0 1.7 2.3 0.8 1.9 -0.2 2.4 1.9 -0.2 0.7 0.3 1.7 1.9 0.5 -0.2 0.1
Arm fat mass (left) 0.2 0.8 4.4 -1.4 -2.1 0.0 -1.5 0.0 0.4 -1.1 -0.0 -1.1 0.1 -0.0 -1.2 -0.8 -0.4 -0.0 -0.0 -0.1 -1.0 -1.0
Number of self-reported non-cancer illnesses 0.9 1.6 6.3 1.1 0.3 -0.8 2.5 -0.9 -2.4 -1.5 -1.4 0.4 -2.2 -1.5 -0.1 -0.3 0.4 -1.2 -1.5 0.1 0.3 0.3
Average weekly champagne plus white wine intake 0.6 0.9 2.1 -0.0 0.8 -1.5 -0.8 1.4 0.4 -0.3 1.4 0.8 1.1 1.3 -0.1 1.2 0.9 1.1 1.1 0.5 -0.3 1.0
Miserableness 2.0 3.5 6.1 -2.4 -1.3 2.0 0.2 -2.0 -1.2 -0.9 -1.6 -2.5 -1.2 -1.6 -2.2 -1.6 -2.4 -1.9 -1.7 -2.3 -2.4 -2.3
Guilty feelings 0.3 0.5 2.4 0.2 -0.6 -0.9 -0.1 0.4 -0.1 -0.6 0.2 1.0 -0.4 0.3 0.7 0.3 1.5 0.4 0.3 1.4 -0.3 1.0
Wears glasses or contact lenses 0.3 0.4 1.1 0.2 -0.8 0.9 0.9 0.0 -0.8 0.2 -0.4 -0.4 -0.7 -0.6 -0.4 1.0 -0.3 -0.3 -0.7 -1.0 -0.3 -0.4
Ever taken oral contraceptive pill 0.5 0.5 5.1 0.9 -0.2 -0.4 0.5 0.5 -0.2 -0.1 0.4 0.9 0.3 0.2 0.9 0.6 0.3 0.4 0.2 0.1 2.3 0.6
Hearing aid user 0.4 0.5 1.1 -0.6 0.4 0.4 -1.1 0.8 1.0 1.1 0.7 0.2 0.6 0.9 0.4 0.6 0.6 0.9 0.9 0.4 -0.5 0.3
Mother’s age at death 1.4 1.8 5.0 -0.1 -0.5 1.2 2.0 -1.8 -0.9 0.4 -2.1 -0.6 -2.2 -1.7 -0.4 -1.8 -1.2 -1.4 -1.5 -0.9 -0.8 -0.8
Financial situation satisfaction 1.6 1.9 5.7 -0.1 0.3 0.3 2.1 -1.5 -2.2 -2.4 -1.6 -0.3 -1.9 -1.7 -0.9 -1.7 -0.7 -1.6 -1.7 -0.3 0.3 -0.5
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.1 0.6 -0.5 -0.0 1.1 -0.6 -0.8 -0.0 -0.5 0.3 -0.6 -0.6 0.3 -0.1 0.0 -0.6 -0.6 -0.0 0.1 0.2
Commuting to job workplace: Public transport 1.2 1.5 2.9 -1.6 -1.1 1.0 0.8 -1.1 -0.5 -1.1 -1.6 -1.2 -1.6 -1.5 -1.2 -1.7 -1.0 -1.1 -1.4 -0.2 -0.7 -1.3
Eye problems/disorders: Glaucoma 0.4 0.5 2.2 0.6 0.9 -1.5 0.7 0.6 -0.3 0.5 0.3 0.9 -0.3 0.2 0.8 1.3 0.9 0.5 0.2 0.3 0.4 0.9
Medication: Blood pressure 0.3 0.6 2.6 1.5 -0.3 0.1 1.6 -0.5 -1.2 -0.3 -0.8 0.6 -1.3 -0.8 0.5 -0.0 0.3 -0.5 -0.7 0.1 0.9 0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.8 -1.0 0.1 0.8 -1.4 0.2 0.3 -0.7 0.7 -0.7 1.0 0.5 -0.8 -0.5 -0.8 0.2 0.5 -0.8 0.1 -0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.6 1.4 -0.5 -0.5 -0.3 0.4 -1.0 -0.7 -1.0 -0.8 -0.7 -0.2 -0.9 -1.0 -1.2 -0.8 -1.1 -0.9 0.1 -0.5 -0.7
High cholesterol (Self-reported) 0.2 0.3 1.6 0.4 -0.3 -0.6 0.5 0.0 -0.6 -1.3 -0.3 0.3 -0.8 -0.4 -0.4 -0.3 0.5 -0.2 -0.4 0.7 -0.1 0.3
Medication: Bendroflumethiazide 0.2 0.4 1.7 0.7 -0.2 -0.3 -0.8 0.8 0.8 -0.1 0.5 0.3 0.4 0.5 0.1 -0.1 0.8 0.7 0.6 1.3 0.2 0.3
Medication: Paracetamol 0.7 1.0 3.0 -0.6 0.6 0.2 0.6 -1.3 -1.3 -1.7 -0.9 -0.9 -0.8 -1.0 -1.0 -1.3 -1.1 -1.3 -1.0 -1.0 -0.4 -0.9
Medication: Lisinopril 4.7 6.0 11.8 2.6 0.9 -1.6 -0.8 2.5 2.0 2.9 2.5 2.8 2.4 2.5 3.2 2.9 2.2 2.6 2.6 1.5 3.4 2.6
Medication: Atorvastatin 0.4 0.5 1.5 1.1 -0.2 -0.2 0.3 0.8 0.3 0.2 0.3 1.1 -0.2 0.4 0.7 0.4 1.2 0.8 0.5 1.2 0.8 1.1
Illnesses of father: High blood pressure 0.5 0.6 2.4 -0.8 0.2 0.7 -0.8 -0.3 -0.1 -1.6 -0.2 -1.2 0.2 -0.4 -1.5 -0.8 -0.8 -0.5 -0.5 -0.3 -0.8 -1.1
Alcohol drinker status: Never 2.8 3.3 7.0 -0.0 -0.4 1.0 2.1 -2.6 -2.2 -1.2 -2.4 -1.4 -2.0 -2.4 -1.4 -2.0 -1.8 -2.6 -2.3 -1.3 -1.3 -1.5
Ever smoked 0.4 0.6 2.3 -1.5 0.4 1.2 -1.0 -0.2 0.6 -0.4 -0.3 -1.1 0.1 -0.2 -1.0 -1.4 -1.1 -0.1 -0.1 -0.3 0.1 -1.2
Basal metabolic rate 0.4 2.2 8.9 -1.1 -1.3 -0.8 -3.0 1.7 2.2 0.7 1.9 0.0 2.3 1.9 -0.1 0.8 0.6 1.7 1.9 0.7 -0.3 0.3
Leg fat percentage (left) 0.2 0.6 4.0 -0.2 -2.0 -1.0 -0.0 -0.5 -0.5 -1.1 -0.7 -0.4 -0.9 -0.6 -0.5 -1.0 0.0 -0.5 -0.6 0.4 -0.5 -0.4
Arm fat-free mass (left) 0.6 3.0 9.7 -0.8 -0.8 -1.1 -3.1 2.1 2.4 1.2 2.4 0.5 2.7 2.4 0.3 1.3 1.0 2.1 2.3 1.0 -0.3 0.8
Number of operations (self-reported) 3.0 4.4 12.4 -0.7 1.3 -1.1 -3.5 3.3 2.3 0.5 3.2 0.5 3.2 2.8 -0.1 2.3 1.2 2.8 2.6 0.8 0.3 0.9
Average weekly beer plus cider intake 0.9 1.3 5.0 1.3 0.7 -1.4 -1.7 0.3 1.9 0.6 0.7 0.7 1.4 0.9 1.0 -0.7 0.9 0.6 1.1 2.2 0.6 0.6
Irritability 0.4 0.7 2.7 1.6 0.9 -0.7 0.6 0.4 0.1 1.0 0.5 1.2 0.4 0.5 1.4 0.7 0.7 0.5 0.6 0.5 1.2 1.1
Risk taking 0.9 1.3 3.2 0.3 1.0 -0.9 -1.1 1.8 1.2 0.8 1.4 0.8 1.2 1.4 0.3 1.1 1.1 1.6 1.3 1.2 0.4 0.9
Ever had prostate specific antigen (PSA) test 2.6 3.0 7.1 -0.3 -1.5 2.7 2.3 -1.7 -2.1 -0.9 -2.1 -1.1 -2.6 -2.1 -1.0 -1.4 -1.5 -1.7 -2.0 -1.8 -0.3 -1.3
Fractured/broken bones in last 5 years 1.1 1.4 2.6 -1.2 -1.0 1.3 0.2 -1.6 -0.7 -0.5 -1.4 -1.5 -1.1 -1.3 -1.0 -1.6 -1.3 -1.4 -1.2 -1.0 -1.2 -1.5
Age started oral contraceptive pill 0.3 0.3 1.7 0.2 0.3 1.3 0.2 -0.6 0.1 0.9 -0.6 -0.4 -0.5 -0.4 -0.0 -0.2 -0.2 -0.4 -0.4 -0.2 -1.2 -0.3
Diastolic blood pressure, automated reading 0.5 1.5 6.3 1.6 -0.1 -1.0 2.4 0.4 -1.4 1.0 0.1 1.4 -0.6 -0.1 1.6 2.5 0.9 0.1 -0.2 -0.6 1.5 1.3
Ever depressed for a whole week 1.4 1.7 5.5 -0.4 0.2 0.9 2.3 -1.5 -1.9 -0.5 -1.8 -0.5 -2.1 -1.7 -0.6 -1.0 -0.8 -1.5 -1.7 -0.9 -0.3 -0.6
Unable to work because of sickness or disability 0.4 0.5 1.2 0.2 0.1 -0.7 0.7 -0.7 -0.7 -1.1 -0.9 -0.0 -1.1 -0.9 -0.4 -1.1 0.2 -0.7 -0.8 0.9 -0.5 -0.1
Commuting to job workplace: Cycle 0.1 0.2 0.8 -0.1 -0.1 -0.7 -0.4 0.4 0.0 -0.9 0.3 -0.2 0.3 0.1 -0.8 0.2 0.1 0.1 0.0 0.3 -0.5 0.0
Myopia 0.6 0.9 2.1 0.0 -0.9 1.0 1.4 -1.0 -1.3 -0.5 -1.1 -0.6 -1.2 -1.2 -0.6 -0.3 -1.0 -1.1 -1.2 -1.3 -0.2 -0.7
Vascular/heart problems diagnosed by doctor 0.8 2.2 7.1 -1.1 0.6 0.3 -2.5 1.3 2.7 2.2 1.6 0.1 2.0 1.9 0.3 0.7 0.6 1.6 1.9 0.8 -1.7 0.5
Cholesterol lowering medication 0.5 0.7 2.0 0.5 0.2 -0.8 -0.5 0.7 0.5 0.4 0.7 1.2 0.4 0.9 1.0 0.3 1.3 0.9 0.9 1.4 0.4 1.2
Medication: Omeprazole (e.g. Zanprol) 0.9 1.0 3.4 -0.3 -1.1 -0.3 1.1 -1.4 -0.7 -0.6 -1.6 -0.3 -1.6 -1.4 -0.1 -1.8 -0.1 -1.2 -1.2 0.9 -0.5 -0.4
Pain experienced in last month 0.2 0.3 1.1 -0.2 -0.8 -0.6 -0.6 0.7 0.3 -0.0 0.7 0.3 0.9 0.5 0.3 1.1 0.3 0.5 0.4 0.1 0.7 0.3
Supplements: Calcium 0.2 0.2 0.9 -0.2 -1.0 0.4 0.0 -0.8 -0.1 0.3 -0.4 -0.3 -0.0 -0.4 0.3 -0.8 -0.5 -0.6 -0.3 -0.1 0.6 -0.5
Basal cell carcinoma (self-reported) 2.1 2.5 6.2 0.3 2.4 -1.6 -2.3 1.3 1.7 1.2 2.2 0.8 2.5 2.3 0.7 1.0 0.8 1.6 2.2 0.4 -0.6 1.1
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.5 -1.6 -0.5 -0.3 -1.1 -0.5 0.1 -0.9 -0.1 -1.1 0.3 -0.1 -1.0 -1.0 -0.6 -0.4 -0.1 -0.3 -1.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.9 0.8 -1.4 -0.8 0.5 -0.0 -0.1 -0.0 0.0 0.6 0.1 -0.0 0.6 0.1 0.4 -0.0 0.0 0.6 0.8 0.5
Heart disease (siblings) 1.0 1.2 3.7 0.9 1.9 -1.5 -1.0 0.9 0.6 0.3 1.2 1.0 1.2 1.2 1.0 0.8 1.2 0.9 1.2 1.1 0.5 1.1
Alcohol drinker status: Previous 0.6 0.7 2.5 -0.3 -0.5 -1.6 -1.0 0.8 1.0 0.3 0.8 0.7 0.4 1.0 0.3 -0.1 1.0 1.0 1.0 1.2 -0.6 0.8
Pack years of smoking 2.4 3.5 7.7 0.8 1.0 -2.0 -2.8 2.5 2.3 0.8 2.5 1.1 2.6 2.3 0.7 1.8 1.5 2.3 2.2 1.6 0.8 1.3
Impedance of whole body 0.3 1.3 3.3 0.2 0.3 1.4 1.8 -1.6 -1.3 -0.3 -1.6 -0.7 -1.4 -1.6 -0.2 -0.6 -1.1 -1.6 -1.6 -1.0 0.1 -0.9
Leg fat mass (left) 0.1 0.5 2.1 -0.6 -1.5 -1.0 -1.5 0.5 0.6 -0.7 0.6 -0.3 0.6 0.5 -0.4 -0.1 0.3 0.5 0.5 0.5 -0.4 -0.2
Arm predicted mass (left) 0.6 2.9 9.2 -0.8 -0.7 -1.2 -3.0 2.0 2.3 1.0 2.4 0.5 2.6 2.4 0.3 1.2 1.0 2.1 2.3 0.9 -0.3 0.8