[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr15:62,636,766-66,097,711

Best TWAS P=2.57e-15 · Best GWAS P=3e-28 conditioned to 7.2e-09

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	NTR	Blood	TPM1	0.09	0.04	enet	20	0.06	2.9e-19	6.843	-7.9	2.6e-15	0.02	1.00	0.00	TRUE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	HERC1	0.07	0.05	lasso	2	0.03	4.6e-03	8.190	7.7	1.6e-14	-0.15	0.11	0.05	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	RASL12	0.03	0.03	lasso	2	0.02	1.1e-03	6.446	-6.5	1.0e-10	0.02	0.00	0.98	TRUE
7	GTEx	Breast Mammary Tissue (Female)	USP3	0.41	0.07	lasso	8	0.12	2.0e-04	-7.006	6.4	1.7e-10	-0.62	0.12	0.24	TRUE
6	GTEx	Brain Putamen basal ganglia	PIF1	0.23	0.17	enet	10	0.18	4.3e-05	4.963	5.9	3.1e-09	0.06	0.26	0.28	TRUE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	HERC1	0.02	0.01	blup	99	0.02	3.6e-05	0.099	5.4	5.5e-08	-0.18	0.51	0.02	TRUE
19	YFS	Blood	TPM1	0.28	0.13	enet	37	0.20	8.7e-64	6.170	-6.7	1.8e-11	0.03	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	USP3	0.09	0.01	blup	69	0.02	1.5e-03	8.185	6.3	2.7e-10	-0.20	0.03	0.03	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKDD1A	0.09	0.10	lasso	4	0.09	2.2e-10	5.803	5.9	3.2e-09	0.10	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	PLEKHO2	0.04	0.05	lasso	3	0.04	4.8e-04	-5.814	5.9	3.3e-09	0.11	0.01	0.96	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	ANKDD1A	0.05	0.03	enet	9	0.06	1.5e-07	5.803	5.8	5.3e-09	0.09	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	PLEKHO2	0.07	0.01	blup	46	0.03	4.2e-03	-5.704	5.8	5.9e-09	0.10	0.01	0.90	FALSE
17	GTEx	Whole Blood	PLEKHO2	0.20	0.11	lasso	6	0.18	3.6e-16	-5.191	5.8	6.9e-09	0.10	0.21	0.79	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ANKDD1A	0.44	0.56	lasso	1	0.55	2.2e-21	5.767	5.8	8.1e-09	0.09	0.14	0.86	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	PLEKHO2	0.25	0.20	lasso	4	0.20	1.1e-07	-5.814	5.7	1.1e-08	0.10	0.20	0.77	FALSE
4	GTEx	Brain Caudate basal ganglia	PIF1	0.18	0.08	enet	9	0.06	8.9e-03	5.387	5.7	1.2e-08	0.09	0.10	0.13	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	PLEKHO2	0.02	0.03	lasso	1	0.02	7.0e-04	-5.554	5.5	2.8e-08	0.09	0.01	0.92	FALSE
14	GTEx	Nerve Tibial	PLEKHO2	0.17	0.13	lasso	3	0.13	1.1e-09	-5.704	5.5	2.9e-08	0.10	0.17	0.83	FALSE
2	GTEx	Adipose Visceral Omentum	UBAP1L	0.10	0.08	enet	6	0.08	6.9e-05	5.188	5.5	3.0e-08	0.09	0.04	0.95	FALSE
3	GTEx	Artery Tibial	PLEKHO2	0.37	0.31	lasso	5	0.30	2.6e-24	-5.703	5.5	3.9e-08	0.13	0.18	0.82	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLEKHO2	0.03	0.03	lasso	6	0.03	9.4e-04	-4.978	5.5	4.1e-08	0.10	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Esophageal Carcinoma	ANKDD1A	0.19	0.06	blup	51	0.13	6.8e-05	5.387	5.5	4.6e-08	0.10	0.01	0.85	FALSE
13	GTEx	Esophagus Muscularis	PLEKHO2	0.31	0.32	lasso	5	0.31	5.0e-19	-5.704	5.5	5.1e-08	0.11	0.21	0.79	FALSE
16	GTEx	Thyroid	UBAP1L	0.15	0.06	enet	13	0.08	1.6e-06	4.874	5.4	5.4e-08	0.08	0.12	0.87	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	CILP	0.06	0.06	enet	7	0.06	3.1e-07	-4.084	5.4	5.4e-08	-0.05	0.65	0.25	FALSE
38	The Cancer Genome Atlas	Stomach Adenocarcinoma	ANKDD1A	0.13	0.12	lasso	4	0.11	1.5e-08	5.387	5.4	5.4e-08	0.10	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ANKDD1A	0.11	0.13	lasso	1	0.13	9.0e-07	5.387	5.4	7.2e-08	0.09	0.01	0.99	FALSE
12	GTEx	Esophagus Mucosa	ANKDD1A	0.15	0.16	lasso	4	0.17	1.8e-11	5.767	5.4	8.1e-08	0.11	0.15	0.85	FALSE
10	GTEx	Colon Transverse	PLEKHO2	0.16	0.11	lasso	3	0.08	1.4e-04	-5.191	5.3	9.4e-08	0.08	0.23	0.59	FALSE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	CILP	0.03	0.03	blup	36	0.02	1.5e-02	-3.505	5.3	1.3e-07	-0.04	0.03	0.08	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLEKHO2	0.02	0.02	lasso	2	0.01	3.8e-04	-5.191	5.3	1.4e-07	0.07	0.02	0.97	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	LACTB	0.25	0.04	enet	12	0.19	1.9e-06	4.592	-5.2	1.7e-07	-0.08	0.01	0.88	FALSE
15	GTEx	Small Intestine Terminal Ileum	UBAP1L	0.23	0.13	lasso	5	0.08	8.0e-03	4.701	5.2	1.8e-07	0.06	0.02	0.81	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ANKDD1A	0.18	0.11	enet	19	0.11	9.4e-14	-4.978	-5.2	2.1e-07	-0.03	0.36	0.64	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	CILP	0.04	0.01	blup	36	0.02	2.2e-03	4.567	5.2	2.3e-07	0.03	0.02	0.35	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ANKDD1A	0.07	0.02	blup	51	0.04	9.6e-03	5.803	5.2	2.3e-07	0.11	0.01	0.82	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS27L	0.07	0.04	blup	44	0.02	8.7e-04	4.125	-5.2	2.4e-07	0.01	0.04	0.73	FALSE
5	GTEx	Brain Frontal Cortex BA9	FAM96A	0.32	0.02	enet	22	0.06	1.4e-02	8.185	5.2	2.5e-07	-0.15	0.05	0.07	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP	0.03	0.01	lasso	4	0.02	8.6e-06	-3.949	5.2	2.6e-07	-0.02	0.36	0.24	FALSE
9	GTEx	Colon Sigmoid	ANKDD1A	0.28	0.17	lasso	7	0.14	1.6e-05	-5.704	5.1	2.8e-07	0.11	0.21	0.72	FALSE