TWAS hub - SECISBP2L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.064	0.029	0.00410	0.046	NA	0.062	NA	0.049	2.0e-04	NA	1.7e-05	NA	1.3e-04
2	TCGA	Thyroid Carcinoma	0.077	0.030	0.00025	0.065	0.047	0.065	NA	0.062	6.9e-07	2.3e-05	6.4e-07	NA	1.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung FEV1/FVC ratio	14.0	71.1	81.9	7.8	9.1
Medication: Ibuprofen	8.8	10.5	11.6	3.1	3.4
Medication: Ibuprofen (e.g. Nurofen)	7.4	9.5	10.3	2.9	3.2
HbA1C	4.8	5.4	7.7	-1.8	-2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.5	5.3	6.4	-2.1	-2.5
Breast cancer (self-reported)	4.3	5.1	8.2	1.5	2.9
Handedness (chirality/laterality): Left-handed	4.2	5.0	7.0	-1.8	-2.6
Pain all over the body in last month	4.0	4.3	7.5	-2.7	-1.0
Ever had prostate specific antigen (PSA) test	4.0	4.6	5.6	1.9	2.4
Medication for hormone replacement therapy	3.8	4.2	7.6	-2.8	-0.9
Ever smoked	3.8	6.7	7.9	2.4	2.8
Illnesses of siblings	3.4	4.8	5.4	2.0	2.3
Medication for cholesterol	3.4	5.1	8.3	2.9	1.4
Peak expiratory flow (PEF)	3.2	7.4	10.1	3.2	2.2
Medication: Metformin	3.1	4.4	6.4	-1.5	-2.5
Father’s age at death	3.1	4.1	5.7	-1.6	-2.4
Length of working week for main job	3.0	3.3	5.2	-2.3	-1.2
Diastolic blood pressure, automated reading	2.9	9.1	11.6	-2.6	-3.4
Family relationship satisfaction	2.8	3.4	6.2	-0.8	-2.5
Age at first live birth	2.6	4.7	6.7	2.6	1.6
Suffer from ‘nerves’	2.6	4.1	7.0	-1.0	-2.7
Headache pain in last month	2.5	4.2	8.5	2.9	-0.0
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	7.3	-0.8	-2.7
Number of operations (self-reported)	2.5	3.7	7.4	0.1	2.7
Alzheimer’s Disease (in mother)	2.4	2.8	3.6	1.4	1.9
Breast Cancer	2.4	5.8	10.5	-1.1	-3.2
Allergy	2.4	5.6	6.2	2.2	2.5
Age at last live birth	2.4	3.5	5.0	2.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	3.1	-1.8	-1.4
Depressed Affect (Nagel 2018)	2.3	4.9	6.4	2.5	1.8
Respiratory disease	2.3	5.0	7.3	-1.7	-2.7
Chronic bronchitis/emphysema (father)	2.3	2.7	3.4	-1.9	-1.4
Past tobacco smoking	2.3	4.3	5.5	-1.8	-2.3
Chest pain or discomfort	2.3	3.4	4.4	-1.5	-2.1
Alcohol drinker status: Previous	2.2	2.5	3.1	1.4	1.7
Rheumatoid Arthritis	2.1	2.8	3.1	-1.8	-1.6
Relative age voice broke	2.1	3.3	5.0	-1.2	-2.2
Fractured/broken bones in last 5 years	2.1	2.7	3.4	1.9	1.4
Myopia	2.1	3.0	5.6	2.4	0.7
Ulcerative Colitis (UC)	2.0	3.8	5.4	2.3	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	4.3	0.9	-2.1
LDL Cholesterol	1.9	3.0	4.7	1.2	2.2
Had major operations	1.9	2.2	4.3	0.4	2.1
Illnesses of father: None of the above (group 1)	1.9	2.4	2.5	1.6	1.5
Irritable Bowel Disease (IBD)	1.8	4.4	7.2	2.7	1.2
Relative age of first facial hair	1.8	3.8	5.1	-2.3	-1.6
Exposure to tobacco smoke at home	1.8	2.1	2.5	-1.6	-1.3
Guilty feelings	1.8	2.8	4.2	-2.1	-1.1
Allergy or Eczema	1.7	4.5	4.6	-2.1	-2.2
Angina	1.7	2.3	2.4	-1.4	-1.6
Severe depression (siblings)	1.7	1.9	3.6	-0.4	-1.9
Medication: Seretide 50 evohaler	1.7	2.0	2.4	-1.2	-1.5
Medication: Lisinopril	1.7	2.2	2.5	-1.6	-1.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.6	-1.9	-0.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	1.8	-1.3	-1.3
Medication: Levothyroxine sodium	1.6	2.8	3.0	1.6	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.6	-1.1	-1.6
Number of self-reported non-cancer illnesses	1.6	2.7	3.9	-1.2	-2.0
Hearing difficulty/problems: Yes	1.5	2.3	4.4	-0.3	2.1
Had other major operations	1.5	1.8	3.4	0.4	1.8
Worrier / anxious feelings	1.5	2.9	5.7	-0.2	-2.4
Health satisfaction	1.5	1.9	2.3	-1.2	-1.5
Ever depressed for a whole week	1.5	1.8	3.7	-0.2	-1.9
Type 2 Diabetes (T2D) (2018)	1.4	2.6	3.5	-1.9	-1.3
Sensitivity / hurt feelings	1.4	2.4	3.3	-1.2	-1.8
Diabetes (father)	1.4	1.8	2.2	-1.2	-1.5
Number of incorrect matches in round	1.4	2.3	3.0	1.7	1.2
Impedance of arm (right)	1.4	6.6	11.8	3.4	1.2
Prospective memory result	1.4	1.7	1.8	-1.3	-1.3
Birth weight	1.4	3.0	4.7	-2.2	1.1
High blood pressure (siblings)	1.4	2.0	2.9	-1.1	-1.7
Migraine (self-reported)	1.4	1.8	2.9	1.7	0.8
Ovarian Cancer	1.3	1.7	3.1	0.6	-1.8
Lupus	1.3	2.0	3.5	1.9	0.6
Hair/balding pattern: Pattern 2	1.3	1.7	1.9	1.4	-1.2
Falls in the last year	1.3	1.8	3.5	-0.1	1.9
Wheeze or whistling in the chest in last year	1.3	2.3	3.8	-0.9	-1.9
Heart disease (mother)	1.3	1.6	2.7	-1.6	-0.6
Alcohol intake frequency.	1.3	3.0	6.0	2.4	0.2
Pack years of smoking	1.3	1.9	3.6	-0.3	1.9
Qualifications: CSEs or equivalent	1.2	1.6	2.3	1.5	0.9
Diabetes (self-reported)	1.2	1.8	2.2	-1.5	-1.2
Hair/balding pattern: Pattern 4	1.2	2.8	5.0	-2.2	-0.8
Angina (self-reported)	1.2	1.5	1.8	-1.1	-1.4
Leg pain on walking	1.2	1.5	2.8	0.5	1.7
Smoking status: Previous	1.2	1.8	2.5	1.1	1.6
Asthma (self-reported)	1.2	2.3	3.6	-1.0	-1.9
Mother’s age at death	1.2	1.6	2.7	1.7	-0.6
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.4	1.2	1.1
Chronotype (morning person)	1.1	2.6	3.6	-1.9	-1.2
Pack years adult smoking proportion	1.1	1.7	3.1	-0.5	1.8
Nervous feelings	1.1	2.1	4.0	-0.4	-2.0
Medication: Ramipril	1.1	1.4	2.0	-0.9	-1.4
Medication: Simvastatin	1.1	1.6	1.7	-1.3	-1.2
Comparative height size at age 10	1.1	6.2	7.5	2.2	2.7
Miserableness	1.1	1.9	2.4	1.6	1.2
Commuting to job workplace: Public transport	1.1	1.3	2.1	1.5	0.7
Unable to work because of sickness or disability	1.1	1.4	1.6	-1.1	-1.3
Fasting Glucose	1.0	1.2	1.5	-1.2	-1.0
Taking other prescription medications	1.0	1.6	3.2	1.8	0.2
Financial difficulties in last 2 years	1.0	1.3	2.4	1.5	0.5
Noisy workplace	1.0	1.2	2.4	-0.3	-1.5
Depression (self-reported)	1.0	1.2	1.3	1.1	-1.1
Eye problems/disorders: None of the above	1.0	1.1	1.4	1.2	0.9
Pulse rate, automated reading	1.0	3.1	5.2	-1.1	-2.3
Diabetes diagnosed by doctor	1.0	1.6	1.8	-1.3	-1.2
Back pain experienced in last month	1.0	1.4	1.5	1.2	1.2
Reaction Time	0.9	1.7	2.1	-1.4	-1.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.7	-1.3	-0.7
Systolic blood pressure, automated reading	0.9	2.6	4.1	-2.0	-1.0
Medication: Co-codamol	0.9	1.0	1.5	0.7	1.2
Arm fat percentage (right)	0.9	3.5	5.4	1.2	2.3
Asthma	0.9	1.8	2.6	-1.0	-1.6
Lung cancer (father)	0.9	1.0	1.9	-1.4	-0.4
Tense / ‘highly strung’	0.9	1.5	2.8	-0.5	-1.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	1.9	-1.0	-1.4
Chronic bronchitis/emphysema (mother)	0.9	1.0	1.1	1.0	1.0
Comparative body size at age 10	0.9	2.4	4.6	0.5	2.1
Eye problems/disorders: Cataract	0.9	1.0	1.2	-0.9	-1.1
Hearing aid user	0.9	1.0	1.9	0.2	1.4
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.3	-0.9	-1.1
Heart disease (siblings)	0.9	1.1	2.2	-1.5	-0.3
Worry (Nagel 2018)	0.8	1.6	2.9	1.7	-0.6
Alzheimer’s Disease (in father)	0.8	0.9	1.1	-0.8	-1.1
Ulcerative Colitis	0.8	1.1	1.2	1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.2	-1.1	-0.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	2.0	-1.4	-1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.5	-0.7	-1.2
Time employed in main current job	0.8	0.9	1.6	-0.5	-1.3
Impedance of arm (left)	0.8	3.8	7.5	2.7	0.2
Blood clot in the leg (DVT)	0.8	1.1	1.3	-0.9	-1.1
Mood swings	0.8	1.4	1.8	1.4	1.0
Mineral and other dietary supplements	0.8	1.0	2.1	-0.0	1.4
Osteoarthritis (self-reported)	0.8	1.1	1.4	-1.2	-0.9
Age started oral contraceptive pill	0.8	0.9	1.8	1.3	0.3
Cholesterol lowering medication	0.8	1.2	2.3	-1.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	1.3	-0.9	-1.1
Crohns Disease (2012)	0.7	1.1	2.0	1.4	0.5
Mean Putamen Volume	0.7	0.8	1.0	-1.0	-0.7
Systolic Blood Pressure	0.7	3.7	4.2	-2.1	-1.8
Trunk fat percentage	0.7	3.0	4.7	1.1	2.2
Mouth/teeth dental problems	0.7	1.1	1.8	0.6	1.3
Medication: Lansoprazole	0.7	0.8	1.3	-1.2	-0.4
Number of children fathered	0.7	0.8	1.6	-1.3	0.1
Medication for pain relief, constipation, heartburn	0.7	1.3	1.9	-1.4	-0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.5	-1.2	0.2
Loneliness, isolation	0.7	1.0	2.0	-0.2	-1.4
Medication: Blood pressure	0.7	1.2	1.8	-1.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.9	0.2	-1.4
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.0	1.0	1.7
Schizophrenia (2018)	0.6	1.2	2.1	1.5	-0.5
Schizophrenia (2014)	0.6	1.3	1.8	0.9	-1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	0.3	1.1
High blood pressure	0.6	1.8	3.0	-0.8	-1.7
Multivitamins +/- minerals	0.6	0.8	1.6	1.3	0.1
Alcohol intake versus 10 years previously	0.6	0.9	1.6	1.2	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-1.3	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.1	0.8	-1.1
Gout (self-reported)	0.6	0.8	1.5	-0.0	-1.2
Arm fat-free mass (right)	0.6	3.1	6.1	-2.5	0.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	0.8	0.9	0.8
Medication: Allopurinol	0.6	0.8	1.2	1.1	-0.6
Long-standing illness, disability or infirmity	0.6	0.9	1.0	0.9	1.0
Ever had bowel cancer screening	0.6	0.7	1.1	0.6	-1.1
Alcohol drinker status: Never	0.6	0.8	1.0	1.0	-0.7
Crohns Disease (2017)	0.5	1.2	2.3	1.5	0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.1	-1.4	0.4
Coronary Artery Disease (CAD)	0.5	0.6	0.7	-0.7	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.0	-1.0	-0.6
Blood Eosinophil Count	0.5	3.8	6.2	1.2	2.5
Blood Platelet Count	0.5	6.2	12.3	0.4	-3.5
Smoking Status	0.5	1.3	1.9	0.9	1.4
Townsend deprivation index at recruitment	0.5	0.7	0.9	0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.3	-1.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.4	-1.2	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	-0.9	-0.6
Trunk fat mass	0.5	2.3	4.3	0.5	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.2	-0.4	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	1.4	-1.2	0.4
Had menopause	0.5	0.7	1.0	-1.0	-0.6
Neuroticism score	0.5	1.1	1.9	-0.6	-1.4
Happiness	0.5	0.6	1.1	1.0	-0.3
Arm fat mass (right)	0.5	2.0	3.9	0.1	2.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.4	0.6	1.2
Medication: Amlodipine	0.5	0.6	0.8	-0.7	-0.9
Body fat percentage	0.5	2.0	3.3	0.8	1.8
Qualifications: College or University degree	0.5	1.6	2.9	-1.7	-0.5
Neck or shoulder pain in last month	0.5	0.7	0.7	-0.8	-0.8
Arm predicted mass (right)	0.5	2.3	4.5	-2.1	0.4
Knee pain experienced in last month	0.5	0.7	1.1	0.5	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	0.5	1.0
Arm fat percentage (left)	0.5	2.0	3.3	0.8	1.8
Arm fat mass (left)	0.5	2.0	4.0	0.2	2.0
Arm fat-free mass (left)	0.5	2.3	3.6	-1.9	1.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	-1.1	-0.2
Impedance of whole body	0.5	2.4	4.7	2.2	-0.1
Arm predicted mass (left)	0.5	2.5	4.2	-2.1	0.8
Major Depression (MDD)	0.4	0.5	0.7	-0.6	-0.8
Age at First Birth	0.4	0.6	0.7	-0.7	-0.8
HDL Cholesterol	0.4	0.6	0.7	0.9	-0.7
Heel T-Score	0.4	3.5	5.0	-2.2	-1.4
Vitamin and mineral supplements	0.4	0.5	1.0	-0.2	1.0
Age when periods started (menarche)	0.4	0.8	1.6	1.3	0.2
Supplements: Glucosamine	0.4	0.6	0.8	0.9	0.6
Body mass index (BMI)	0.4	1.7	3.3	-0.4	1.8
Alcohol usually taken with meals	0.4	0.6	1.0	1.0	0.5
Forced vital capacity (FVC)	0.4	1.7	1.9	-1.2	-1.4
Heart attack	0.4	0.6	0.7	0.6	0.9
Fluid intelligence score	0.4	0.8	1.6	-1.3	-0.0
Weight	0.4	2.0	3.7	-0.5	1.9
Trunk fat-free mass	0.4	2.4	4.6	-2.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.0	1.4	0.8
Trunk predicted mass	0.4	2.5	4.7	-2.2	0.5
Breastfed as a baby	0.4	0.5	0.9	0.9	0.4
Glaucoma (self-reported)	0.4	0.4	0.9	-0.9	-0.1
Mean time to correctly identify matches	0.4	0.7	1.0	-1.0	-0.7
Whole body fat mass	0.4	1.5	3.0	-0.1	1.7
Number of full sisters	0.4	0.5	0.9	0.2	-0.9
Osteoporosis (self-reported)	0.4	0.5	0.7	-0.6	-0.8
Whole body water mass	0.4	2.1	3.3	-1.8	0.9
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	0.1	1.0
Medication: Paracetamol	0.4	0.6	0.7	0.8	0.8
Irritability	0.4	0.6	0.6	-0.8	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.8	0.6	0.9
Leg fat mass (left)	0.4	1.4	2.3	-0.7	1.5
Bipolar Disorder (2018)	0.3	0.4	0.6	-0.8	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	0.8	-0.8	0.9
Neuroticism (Nagel 2018)	0.3	0.7	1.3	1.2	0.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.4	0.6	0.7
Neuroticism (2016)	0.3	0.4	0.8	0.0	-0.9
Hand grip strength (left)	0.3	0.8	1.6	-0.3	-1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.1	-0.9
Leg fat-free mass (left)	0.3	1.5	1.9	-1.1	1.4
Average weekly fortified wine intake	0.3	0.4	0.6	-0.4	-0.8
Leg predicted mass (left)	0.3	1.6	1.8	-1.2	1.3
Waist circumference	0.3	1.0	1.5	-0.6	1.2
Number of live births	0.3	0.4	0.7	-0.2	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.3	-0.5	-0.6
Illnesses of mother	0.3	0.4	0.7	-0.9	0.2
Exposure to tobacco smoke outside home	0.3	0.4	0.5	-0.7	-0.6
Number of full brothers	0.3	0.4	0.4	-0.7	-0.6
Leg fat mass (right)	0.3	1.3	2.2	-0.6	1.5
Medication: Aspirin	0.3	0.4	0.6	-0.3	-0.8
Whole body fat-free mass	0.3	2.0	3.1	-1.8	0.9
Leg fat-free mass (right)	0.3	1.5	1.5	-1.2	1.2
Leg predicted mass (right)	0.3	1.5	1.6	-1.3	1.2
Average weekly champagne plus white wine intake	0.3	0.5	0.8	-0.9	0.2
Ever taken oral contraceptive pill	0.3	0.4	0.4	-0.7	-0.6
Illnesses of father: High blood pressure	0.3	0.3	0.5	0.4	-0.7
Basal metabolic rate	0.3	1.8	2.1	-1.4	1.2
Risk taking	0.3	0.4	0.6	0.5	0.8
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.0	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	0.4	0.6	-0.7
Bipolar Disorder (2011)	0.2	0.2	0.2	0.5	0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.6	0.2
Blood White Count	0.2	1.8	3.3	-0.6	-1.8
BMI	0.2	1.4	2.0	-0.9	1.4
Cardiovascular Disease	0.2	0.6	0.8	-0.6	-0.9
Lung FVC	0.2	1.0	1.2	-0.9	-1.1
Number of treatments/medications taken	0.2	0.3	0.6	0.8	-0.1
Average weekly spirits intake	0.2	0.3	0.5	-0.1	0.7
Hand grip strength (right)	0.2	0.7	1.3	0.2	-1.1
Medication: Atenolol	0.2	0.3	0.5	-0.7	0.3
Sitting height	0.2	1.3	2.2	-1.5	-0.6
High blood pressure (mother)	0.2	0.3	0.6	0.7	0.1
Qualifications: None of the above	0.2	0.4	0.7	0.9	0.2
Hip circumference	0.2	1.0	2.0	-0.1	1.4
Pulse rate	0.2	0.3	0.5	0.0	-0.7
Birth weight of first child	0.2	0.3	0.3	-0.6	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	0.5	-0.6
Leg fat percentage (right)	0.2	0.5	1.0	-0.3	1.0
Medication: Blood pressure	0.2	0.3	0.7	0.1	-0.8
Medication: Omeprazole	0.2	0.2	0.4	-0.2	-0.6
Overall health rating	0.2	0.4	0.5	-0.7	-0.5
Hypertension (Self-reported)	0.2	0.7	1.2	-0.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.7	-0.0
Medication: Aspirin	0.2	0.2	0.4	-0.2	-0.6
Financial situation satisfaction	0.2	0.2	0.5	-0.1	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.5	0.4
Medication: Bendroflumethiazide	0.2	0.2	0.4	-0.1	0.7
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.6	-0.1
Depression (Nagel 2018)	0.1	0.1	0.1	0.4	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	-0.5	0.3
Prostate Cancer	0.1	0.1	0.3	0.1	-0.5
Triglycerides	0.1	0.1	0.1	0.3	0.3
Height	0.1	1.3	2.5	-1.6	-0.4
Waist Hip Ratio (WHR)	0.1	0.6	0.8	-0.9	-0.7
Neuroticism	0.1	0.3	0.4	0.6	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.2
Supplements: Zinc	0.1	0.1	0.2	-0.4	-0.4
Diabetes (mother)	0.1	0.2	0.2	0.3	0.5
Impedance of leg (right)	0.1	0.7	1.3	1.1	-0.3
Current tobacco smoking	0.1	0.1	0.2	-0.5	-0.1
Maternal smoking around birth	0.1	0.2	0.3	-0.4	-0.5
Fed-up feelings	0.1	0.1	0.2	-0.0	-0.4
Impedance of leg (left)	0.1	0.6	1.0	1.0	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.2	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	0.6	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	-0.2	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.4	-0.0
Medication: Cholesterol lowering	0.1	0.2	0.2	-0.3	-0.5
Pulse wave reflection index	0.1	0.1	0.1	0.3	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	-0.1
Medication: Paracetamol	0.1	0.2	0.3	0.5	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.1	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.3	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.0	-0.5
Pulse wave peak to peak time	0.1	0.1	0.1	-0.4	0.3
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.4	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.2	0.3
Illnesses of father: Heart disease	0.1	0.1	0.1	-0.2	0.4
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.3	0.2
Average weekly red wine intake	0.1	0.2	0.3	0.0	0.6
Friendships satisfaction	0.1	0.2	0.3	0.2	0.5
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	-0.1
Medication: Gliclazide	0.1	0.1	0.2	0.1	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.5	-0.5
Leg fat percentage (left)	0.1	0.5	1.0	-0.3	1.0
Pain experienced in last month	0.1	0.2	0.4	-0.3	-0.6
Supplements: Calcium	0.1	0.1	0.2	-0.5	-0.2
Blood Red Count	0.0	0.2	0.4	0.2	0.6
Hypothyroidism (self reported)	0.0	0.1	0.1	0.1	0.3
Hair Pigment	0.0	0.1	0.2	0.1	0.4
Tanning	0.0	0.6	1.2	-0.0	1.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	0.0
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.1	-0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.2	-0.2
Standing height	0.0	0.2	0.4	-0.2	0.7
Loud music exposure frequency	0.0	0.0	0.1	-0.1	-0.3
Worry too long after embarrassment	0.0	0.0	0.0	-0.1	0.1
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.2	0.2
Supplements: Vitamin C	0.0	0.0	0.0	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.2	0.2
Qualifications: nursing, teaching	0.0	0.0	0.0	0.1	-0.1
Smoking status: Current	0.0	0.0	0.0	-0.1	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.4	0.1
Medication: Atorvastatin	0.0	0.0	0.0	0.1	0.1

Hub : Genes

SECISBP2L

Models

Trait associations