Best TWAS P=1.12e-229 · Best GWAS P=9.15e-206 conditioned to 6.44e-56
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LARP6 | 0.06 | 0.06 | blup | 387 | 0.07 | 4.2e-09 | -1.13 | -6.7 | 2.2e-11 | 0.18 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | THSD4 | 0.03 | 0.00 | enet | 19 | 0.01 | 4.6e-02 | -10.98 | 12.9 | 7.4e-38 | -0.21 | 0.11 | 0.07 | TRUE |
| 3 | GTEx | Artery Aorta | THSD4 | 0.24 | 0.10 | lasso | 6 | 0.08 | 2.0e-05 | -30.47 | -32.4 | 1.1e-229 | 0.91 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Brain Cerebellar Hemisphere | MYO9A | 0.33 | 0.07 | lasso | 8 | 0.03 | 7.0e-02 | 3.61 | -11.5 | 8.5e-31 | 0.21 | 0.13 | 0.33 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | LRRC49 | 0.23 | 0.00 | lasso | 8 | 0.00 | 2.1e-01 | 3.06 | 10.8 | 2.2e-27 | -0.22 | 0.08 | 0.08 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | LARP6 | 0.12 | -0.01 | enet | 25 | 0.01 | 1.8e-01 | -1.13 | 7.3 | 4.0e-13 | -0.17 | 0.11 | 0.06 | TRUE |
| 7 | GTEx | Esophagus Gastroesophageal Junction | THSD4 | 0.24 | 0.02 | lasso | 8 | 0.00 | 2.5e-01 | -18.08 | 21.6 | 5.0e-103 | -0.59 | 0.04 | 0.70 | FALSE |
| 8 | GTEx | Stomach | THSD4 | 0.23 | 0.00 | lasso | 5 | 0.00 | 6.5e-01 | 3.55 | -6.0 | 1.6e-09 | 0.27 | 0.08 | 0.25 | TRUE |
| 9 | GTEx | Testis | CTD-2524L6.3 | 0.10 | 0.02 | enet | 13 | 0.03 | 2.1e-02 | 0.28 | -8.3 | 9.3e-17 | 0.17 | 0.28 | 0.03 | TRUE |