Hub : Genes

THSD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.034	0.020	2.9e-02	0.005	0.002	0.007	0.004	0.002	7.8e-02	0.16	4.6e-02	0.1	1.7e-01
2	GTEx	Artery Aorta	0.239	0.064	4.9e-05	0.102	NA	0.081	NA	0.085	3.0e-06	NA	3.1e-05	NA	2.0e-05
3	GTEx	Esophagus Gastroesophageal Junction	0.242	0.084	2.5e-03	0.018	NA	-0.007	NA	0.003	7.1e-02	NA	6.8e-01	NA	2.5e-01
4	GTEx	Stomach	0.231	0.080	2.8e-03	-0.003	NA	-0.006	NA	-0.005	4.5e-01	NA	8.2e-01	NA	6.5e-01
5	GTEx	Testis	0.432	0.122	3.5e-03	0.064	NA	0.023	NA	0.126	8.8e-04	NA	3.3e-02	NA	3.3e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	3.8	-1.0	0.3	-0.4	-1.6	-2.0
Bipolar Disorder or Schizophrenia	1.0	2.5	4.7	-1.7	0.8	0.1	-2.2	-2.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-0.3	-0.9	0.4	-1.1	-0.9
Depression (Nagel 2018)	0.1	0.2	0.7	-0.8	0.2	-0.3	-0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.1	0.5	-0.2	-2.0	-0.4	0.5
Neuroticism (Nagel 2018)	0.3	0.8	2.3	0.6	-0.9	1.5	-0.7	-0.3
Schizophrenia (2018)	0.6	1.3	2.0	-1.4	0.8	0.4	-1.4	-1.3
Schizophrenia vs Biploar Disorder	1.0	1.3	3.3	-0.2	-1.1	1.2	-0.8	1.8
Worry (Nagel 2018)	0.3	0.6	1.3	0.4	-0.9	1.1	-0.9	-0.1
Alzheimer’s Disease (in mother)	0.4	0.4	1.3	0.8	0.4	-0.2	0.2	1.1
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.9	-0.7	0.0	-0.7	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.4	-0.0	0.0	-0.5	0.5
Crohns Disease (2017)	0.2	0.4	1.5	-0.5	-0.2	0.2	1.2	0.4
Irritable Bowel Disease (IBD)	0.5	1.1	2.4	-0.6	1.3	-1.1	1.6	-0.1
Ulcerative Colitis (UC)	0.7	1.3	2.8	0.0	1.7	-1.6	1.1	-0.3
Major Depression (MDD)	0.5	0.6	1.8	-0.2	0.5	-0.2	0.9	1.4
Reaction Time	0.7	1.3	2.2	-1.3	1.0	-0.8	1.0	-1.5
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.4	-0.8	0.2	-0.7	0.5
Breast Cancer	0.3	0.6	1.5	1.0	1.2	-0.4	0.6	-0.3
Ovarian Cancer	0.8	1.1	3.7	-0.3	0.0	-1.2	-0.2	-1.9
Prostate Cancer	1.1	1.6	4.8	0.5	-1.4	0.6	0.8	2.2
Age at First Birth	0.4	0.6	1.3	-1.1	-0.4	-0.5	-1.1	-0.1
Bipolar Disorder (2011)	0.9	0.9	2.5	0.4	1.6	-1.3	0.1	0.5
Body Mass Index (BMI) (2010)	0.3	0.5	1.9	0.6	-0.0	1.4	-0.0	-0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.7	-0.0	0.8	-0.5	0.2	-1.3
Crohns Disease (2012)	0.5	0.9	2.1	-0.5	-1.1	0.5	1.5	0.6
Mean Putamen Volume	1.5	1.8	3.9	-0.3	-2.0	1.8	1.1	-0.5
Fasting Glucose	0.5	0.6	1.9	-0.0	-0.4	0.2	1.4	0.8
HbA1C	1.0	1.1	4.2	0.2	2.0	-0.5	-0.6	0.7
HDL Cholesterol	0.4	0.6	2.1	-1.4	0.6	0.6	0.7	-0.0
LDL Cholesterol	0.1	0.2	0.8	-0.5	-0.2	0.3	0.9	0.0
Lupus	0.4	0.6	1.3	-1.1	0.7	-0.7	0.4	-0.8
Neuroticism (2016)	1.1	1.6	3.5	1.9	-0.2	-1.1	0.2	1.8
Primary Biliary Cirrhosis	0.4	0.6	1.9	-0.5	1.4	0.3	1.0	-0.3
Rheumatoid Arthritis	0.6	0.8	2.6	0.8	0.5	-0.6	0.6	1.6
Schizophrenia (2014)	0.4	1.0	2.9	-1.0	0.8	0.6	-1.7	-0.0
Triglycerides	0.4	0.7	1.4	1.2	-0.2	-1.1	-0.5	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	1.2	-0.7	1.0	-0.8	0.2
Ulcerative Colitis	0.9	1.3	2.6	-1.1	1.6	-1.6	0.6	-0.1
Blood Eosinophil Count	0.2	1.8	4.0	0.8	-2.0	1.2	-1.7	0.2
Blood Platelet Count	0.1	1.6	5.0	-0.5	2.2	-1.2	-1.2	-0.4
Blood Red Count	0.6	5.6	15.7	2.8	4.0	-2.0	0.6	-0.1
Blood White Count	0.4	3.2	8.0	0.8	2.8	-1.6	1.2	1.9
Heel T-Score	0.8	6.3	23.7	-1.9	4.9	-1.7	-0.0	1.1
BMI	0.1	0.6	2.0	0.8	0.6	-0.1	-1.4	0.1
Height	0.2	4.5	10.9	-2.3	3.3	-1.9	0.6	1.5
Waist Hip Ratio (WHR)	0.7	3.3	5.6	2.2	2.3	-2.4	-0.8	0.8
Systolic Blood Pressure	0.8	3.8	13.7	3.7	0.4	-1.6	0.2	1.7
Smoking Status	0.4	0.8	2.7	1.7	0.6	1.0	-0.1	0.3
Allergy or Eczema	0.9	2.3	4.7	2.2	-2.0	1.2	0.6	1.0
Cardiovascular Disease	1.1	3.6	15.4	3.9	-0.7	-1.3	-0.4	0.5
Hypothyroidism (self reported)	0.2	0.5	1.1	0.8	0.5	-0.4	-1.1	-0.5
Respiratory disease	0.9	2.0	3.9	-2.0	1.9	-0.5	1.2	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.7	-0.6	0.8	-1.3	-0.6	-0.1
Lung FEV1/FVC ratio	68.6	347.9	1049.8	12.9	-32.4	21.6	-6.0	4.5
Lung FVC	1.2	5.9	22.5	-2.0	4.7	-1.4	0.9	-0.2
Neuroticism	0.3	0.7	1.1	1.0	-0.8	0.7	-1.1	0.3
Chronotype (morning person)	1.0	2.3	9.9	3.1	-0.2	-0.6	-0.3	1.1
Hair Pigment	0.0	0.7	1.0	0.9	-0.9	0.8	1.0	0.2
Tanning	0.1	1.4	3.6	-1.5	1.9	-0.4	0.8	0.8
Hand grip strength (left)	0.3	0.7	1.6	-1.0	1.3	-0.3	-0.7	0.6
Number of treatments/medications taken	1.4	2.6	6.7	2.6	-1.9	0.5	1.1	-1.0
Average weekly spirits intake	0.9	1.1	3.2	0.3	1.8	-0.1	1.4	-0.5
Sensitivity / hurt feelings	0.8	1.3	2.2	-0.3	-1.0	1.1	-1.5	-1.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	-0.3	0.9	-1.2	-0.1	0.1
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.7	-0.9	0.2	-0.8	-0.1
Relative age of first facial hair	1.0	2.0	5.0	-0.0	-0.1	1.2	2.2	1.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	0.0	-0.8	-0.5	0.2	-0.0
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.6	1.5	0.7	-0.5	-1.6	0.4
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	0.3	0.6	-0.6	-0.4	1.0
Systolic blood pressure, automated reading	1.1	3.3	12.2	3.5	1.0	-1.3	0.1	1.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.7	1.3	-0.2	0.7	0.1	0.7
Angina	1.1	1.4	5.2	0.1	1.1	0.1	2.3	0.9
Medication for hormone replacement therapy	0.4	0.5	2.0	-0.0	-0.3	-0.4	1.4	-0.1
Vitamin and mineral supplements	0.3	0.4	1.4	-0.2	1.2	-0.5	-0.3	0.3
Supplements: Zinc	1.2	1.3	2.8	0.4	-1.7	1.4	-0.1	-1.3
Medication: Co-codamol	0.3	0.3	0.8	-0.5	0.6	0.2	0.9	0.4
Medication: Metformin	0.3	0.4	1.1	1.1	0.8	-0.5	-0.5	-0.2
Diabetes (father)	0.4	0.5	1.2	-1.1	0.7	0.4	0.4	-0.5
Diabetes (mother)	0.9	1.1	2.5	-1.3	1.6	-0.4	1.1	-0.3
Severe depression (siblings)	1.2	1.3	2.5	-1.6	1.2	-0.5	-0.3	1.5
Pack years adult smoking proportion	0.8	1.2	2.5	1.6	-1.3	1.2	-0.6	-0.5
Impedance of leg (right)	0.7	3.3	10.4	-1.1	3.2	-1.6	1.2	-0.8
Leg fat-free mass (left)	0.1	0.3	0.5	-0.2	-0.7	0.5	-0.5	0.5
Trunk fat percentage	0.4	1.5	4.8	0.9	2.2	-1.1	-0.7	-0.2
Hand grip strength (right)	0.6	1.6	4.7	-2.2	-0.0	0.7	-1.1	-1.2
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.2	0.7	-0.8	-0.0	0.6
Current tobacco smoking	0.5	0.9	2.5	0.9	-0.5	1.6	0.4	0.8
Average weekly fortified wine intake	1.3	1.6	5.0	-2.2	1.6	-0.3	0.3	0.1
Maternal smoking around birth	0.4	0.5	0.8	0.9	0.7	-0.8	-0.7	0.5
Fed-up feelings	0.5	0.9	1.7	0.8	-0.7	0.6	-1.3	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.0	0.5	-0.2	0.7	-0.7
Relative age voice broke	1.0	1.5	4.8	-0.0	0.9	-0.3	2.2	1.4
Taking other prescription medications	0.6	0.9	2.8	1.7	-0.6	1.1	0.1	-0.2
Age when periods started (menarche)	0.2	0.4	0.9	-0.9	0.0	0.0	-0.4	-0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.1	0.8	-0.2	0.4	-0.4	1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-0.6	1.0	0.3	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.1	1.1	-0.2	-1.4	-1.0	1.2
Qualifications: CSEs or equivalent	0.6	0.8	2.3	0.4	-1.5	0.6	0.6	-0.7
Serious illness, injury or assault to yourself	0.9	1.0	2.9	0.3	1.1	-1.7	0.7	-0.6
High blood pressure	2.1	5.8	18.7	4.3	-0.4	-1.6	-0.6	2.7
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.5	1.9	-1.2	0.5	0.0	0.3
Multivitamins +/- minerals	0.4	0.5	1.6	-0.0	-0.8	-0.1	-1.3	-0.3
Stomach or abdominal pain in last month	1.7	2.1	5.9	0.1	-2.4	1.5	-1.0	-1.1
Supplements: Glucosamine	2.5	3.3	8.0	-1.9	-1.2	1.6	-2.8	-1.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.0	1.0	0.2	-0.0	-0.1	-0.2
Medication: Atenolol	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.2	0.3
Medication: Levothyroxine sodium	0.3	0.5	1.3	0.3	1.1	-0.2	0.8	-0.8
Sitting height	0.2	1.1	2.0	-1.3	0.4	-0.2	1.4	1.3
Chronic bronchitis/emphysema (father)	0.9	1.0	1.5	-1.2	1.1	-0.2	-1.1	-1.2
High blood pressure (mother)	1.5	2.1	7.6	0.4	-2.8	1.6	-0.3	0.1
Body mass index (BMI)	0.3	1.2	3.5	1.9	-0.6	0.5	-1.2	0.8
Impedance of leg (left)	0.6	3.1	10.4	-0.9	3.2	-1.7	1.1	-0.4
Leg predicted mass (left)	0.1	0.3	0.6	-0.1	-0.8	0.5	-0.5	0.5
Trunk fat mass	0.2	0.9	1.9	0.9	1.4	-0.8	-0.9	0.3
Waist circumference	0.4	1.4	4.9	2.2	0.9	-0.4	0.2	1.1
Number of incorrect matches in round	0.3	0.5	1.6	0.3	0.4	0.1	-0.9	-1.3
Past tobacco smoking	0.5	0.8	3.1	-1.7	-0.0	-1.0	0.2	0.5
Alcohol usually taken with meals	0.8	1.2	2.7	-1.6	1.5	-0.6	0.3	0.8
Nervous feelings	0.2	0.3	0.8	-0.0	-0.9	0.8	0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.2	-0.1	0.2	-1.3	-0.7
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-0.4	0.5	-0.8	-1.0	-0.6
Hair/balding pattern: Pattern 2	1.3	1.6	4.8	0.8	-1.4	2.2	0.1	0.8
Had menopause	0.2	0.2	0.6	-0.2	0.6	-0.2	0.1	-0.8
Had other major operations	1.4	1.7	4.6	1.1	-2.1	1.7	0.5	-0.0
Forced vital capacity (FVC)	1.3	4.9	10.9	-3.2	3.3	-1.3	1.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.0	-1.4	0.9	0.6	0.1	-1.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.0	-1.1	1.4	-1.0	1.4	-0.7
Qualifications: None of the above	1.0	2.2	5.9	2.4	-0.9	-0.6	1.4	1.5
Financial difficulties in last 2 years	0.3	0.4	1.0	0.1	0.0	0.2	-0.9	-1.0
Mouth/teeth dental problems	0.2	0.2	1.1	0.2	-0.2	-0.1	-1.0	0.2
Heart attack	0.2	0.2	0.9	-0.1	0.9	-0.4	0.2	-0.1
Allergy	0.2	0.5	1.1	-0.7	-0.5	0.6	-1.0	-0.7
Pain all over the body in last month	0.4	0.4	1.5	-1.2	-0.0	-0.0	-0.2	-0.6
Diabetes (self-reported)	0.3	0.5	2.0	-0.1	-0.4	-0.3	-1.4	0.2
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	6.8	2.6	-2.5	1.2	-0.8	1.4
Medication: Ramipril	2.1	2.7	5.1	2.2	0.7	-2.2	-1.2	1.4
Medication: Simvastatin	0.7	1.0	3.2	1.8	-0.5	-0.6	-0.4	0.9
Fluid intelligence score	0.2	0.5	0.7	0.9	-0.6	-0.7	-0.5	-0.7
Illnesses of siblings	1.3	1.8	3.0	-1.5	-0.2	1.4	1.7	-1.2
Neuroticism score	0.3	0.7	1.4	0.6	-0.9	0.8	-1.2	-0.5
Weight	0.1	0.4	1.1	0.3	0.2	-0.2	-1.1	0.8
Impedance of arm (right)	0.6	2.6	4.3	-1.5	2.0	-0.9	1.4	-2.1
Arm fat percentage (right)	0.2	0.6	2.8	1.7	0.3	0.0	-0.4	0.2
Trunk fat-free mass	0.2	1.4	5.0	-0.4	-1.1	0.4	-0.7	2.2
Hip circumference	0.1	0.3	0.9	-0.3	-0.3	0.5	1.0	0.3
Time employed in main current job	1.6	1.9	6.1	-2.5	0.9	-0.7	-0.1	-1.4
Alcohol intake versus 10 years previously	0.2	0.4	1.0	0.1	-1.0	0.3	0.2	-0.8
Father’s age at death	0.7	1.0	1.7	-1.1	1.3	-1.1	0.7	-0.6
Worrier / anxious feelings	0.4	0.8	3.0	0.4	-0.3	0.3	-1.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.2	-0.8	-0.3	-0.3	-0.5
Falls in the last year	0.8	1.1	2.0	-0.9	1.1	-1.1	-0.2	-1.4
Hair/balding pattern: Pattern 3	1.5	2.3	3.9	-1.5	1.1	-1.9	0.8	-2.0
Number of live births	0.6	0.9	2.0	-1.4	-0.5	0.1	1.0	-1.1
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	27.4	-0.1	-5.2	4.1	-0.7	0.7
Pulse rate	1.2	2.0	4.4	1.1	-1.9	0.5	-2.1	-0.8
Happiness	0.6	0.7	2.1	-0.6	0.5	-0.2	-0.9	-1.5
Noisy workplace	0.2	0.2	1.0	-0.1	-0.0	0.4	0.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	0.3	-0.7	-0.6	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.6	-1.2	1.0	-0.8	-0.4	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	0.1	-0.2	0.7	-0.2	-0.8
Asthma	0.7	1.4	3.1	-1.7	1.7	0.3	0.8	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.2	1.0	-2.0	0.5	1.9	-0.6
Medication: Cholesterol lowering	0.6	0.9	2.4	1.5	0.7	-0.9	-0.5	0.9
Depression (self-reported)	0.6	0.7	1.7	-0.0	-0.9	1.3	0.1	0.9
Medication: Lansoprazole	0.4	0.4	1.2	1.1	0.3	0.9	-0.3	0.2
Prospective memory result	1.5	1.9	7.2	-2.7	0.9	-0.8	0.3	-0.9
Lung cancer (father)	2.6	3.0	8.1	0.4	-2.2	2.8	-1.4	-0.3
Illnesses of mother	0.4	0.5	1.9	0.6	1.4	0.4	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.2	34.9	0.1	-5.9	4.6	-0.4	0.3
Pulse wave Arterial Stiffness index	1.0	1.2	2.8	-0.3	1.4	-0.3	1.1	1.7
Impedance of arm (left)	0.8	3.9	9.0	-1.8	2.2	-1.1	1.1	-3.0
Arm fat mass (right)	0.1	0.5	1.6	1.3	0.3	-0.1	-0.7	0.4
Trunk predicted mass	0.2	1.4	4.7	-0.3	-1.1	0.5	-0.7	2.2
Standing height	0.3	2.7	9.2	-3.0	1.7	-1.2	0.3	0.3
Length of working week for main job	1.0	1.1	4.5	2.1	-0.3	0.0	-0.9	-0.2
Exposure to tobacco smoke at home	1.4	1.6	4.4	0.9	1.1	-0.7	1.0	2.1
Breastfed as a baby	0.8	1.0	2.4	0.6	1.3	-1.6	-0.6	0.5
Tense / ‘highly strung’	0.2	0.4	0.6	0.8	0.3	-0.6	0.8	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	-0.2	-1.0	0.8	-0.4	0.2
Hair/balding pattern: Pattern 4	0.8	2.0	4.8	1.3	-2.2	1.8	-0.1	-0.7
Birth weight of first child	1.0	1.8	5.3	0.6	1.2	-2.3	-0.2	1.2
Peak expiratory flow (PEF)	9.2	21.4	68.5	1.7	-8.3	5.7	-1.4	1.3
Pulse wave reflection index	1.2	1.5	3.6	0.2	1.1	-0.8	1.9	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.5	0.5	0.7	-0.7	1.1	-1.6
Loud music exposure frequency	0.4	0.5	1.4	0.1	-0.3	0.7	0.5	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	-0.4	0.3	0.0	-1.2	-1.4
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.5	-2.3	0.7	0.6	1.3	-1.4
Blood clot in the leg (DVT)	1.5	1.9	4.1	-0.7	0.7	-1.9	-0.9	-2.0
Medication: Paracetamol	1.8	3.0	6.6	2.6	-2.4	1.4	0.8	0.4
Headache pain in last month	2.6	4.5	9.6	3.0	-3.1	1.1	1.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.1	-1.8	0.0	1.1	0.7	-0.6
Glaucoma (self-reported)	0.8	1.0	1.9	-0.6	-1.4	1.1	-0.5	-1.0
Gout (self-reported)	0.5	0.7	2.2	1.5	0.8	-0.3	0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.4	0.4	-0.4	-0.2	-0.7
Medication: Amlodipine	2.0	2.7	7.4	2.5	0.0	-0.4	0.2	2.7
Medication: Ventolin 100micrograms inhaler	1.2	1.5	3.9	-0.9	2.0	0.6	1.4	0.8
Birth weight	0.0	0.1	0.3	0.2	0.6	-0.1	0.1	-0.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.7	-2.4	1.4	-1.7	1.1	-0.1
High blood pressure (siblings)	0.9	1.3	2.2	1.5	-1.4	-0.3	-1.1	1.1
Forced vital capacity (FVC), Best measure	1.1	4.2	9.1	-3.0	2.8	-1.3	1.1	-0.9
Body fat percentage	0.3	1.0	2.7	1.2	1.6	-0.7	-0.8	-0.2
Leg fat percentage (right)	0.2	0.7	2.7	1.6	0.4	-0.1	-0.6	0.5
Arm fat-free mass (right)	0.2	1.0	3.6	0.4	0.1	-0.2	-1.0	1.9
Exposure to tobacco smoke outside home	0.7	0.9	2.0	-0.2	1.1	-1.0	-1.4	-0.7
Comparative body size at age 10	0.3	0.7	2.4	0.4	-1.5	0.4	-0.5	-0.7
Number of full brothers	0.7	0.9	2.0	0.5	0.7	-1.4	1.0	0.8
Worry too long after embarrassment	0.5	0.8	2.6	0.2	-0.7	1.6	-0.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.1	0.9	-1.8	1.0	-0.4	0.7
Wheeze or whistling in the chest in last year	0.9	1.6	5.2	-1.4	2.3	-0.4	0.4	0.5
Number of children fathered	0.4	0.4	1.7	1.3	-0.5	0.1	0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.8	0.4	0.7	-0.4	-0.7	2.2
Age at first live birth	1.3	2.3	6.4	-2.5	-0.5	0.5	-1.2	-1.8
Pulse wave peak to peak time	1.0	1.2	3.2	-0.1	-1.2	0.3	-1.2	-1.8
Health satisfaction	1.0	1.3	4.2	1.1	-0.7	-0.6	-2.0	-0.0
Shortness of breath walking on level ground	0.3	0.3	0.8	0.7	0.7	-0.2	-0.9	0.0
Qualifications: College or University degree	0.3	1.0	3.0	-0.7	-0.1	1.1	-1.7	0.0
Eye problems/disorders: None of the above	0.4	0.4	1.7	1.3	-0.0	0.1	0.7	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.4	-1.2	0.2	-0.7	0.1	-0.2
Emphysema/chronic bronchitis	1.1	1.3	3.7	0.5	1.4	-1.9	0.7	0.2
Medication for pain relief, constipation, heartburn	1.5	2.5	6.6	-2.6	2.1	-0.1	-0.7	0.9
Neck or shoulder pain in last month	1.0	1.5	4.2	2.1	-0.6	-0.6	0.2	1.5
Medication: Blood pressure	0.7	1.2	2.7	1.6	-0.1	-1.1	-1.2	0.8
Angina (self-reported)	0.9	1.2	4.1	0.1	1.1	0.1	2.0	0.8
Migraine (self-reported)	1.9	2.4	4.9	2.2	-1.6	1.4	1.0	1.3
Medication: Ibuprofen	2.1	2.5	7.3	1.6	-1.5	-0.1	2.7	-0.6
Medication: Allopurinol	0.4	0.5	1.4	1.2	0.1	-0.3	-0.9	-0.1
Medication: Omeprazole	0.5	0.6	1.7	-0.3	1.1	-0.3	0.4	-1.3
Medication: Seretide 50 evohaler	1.3	1.5	4.4	-0.4	2.1	-1.6	0.4	-0.6
Mean time to correctly identify matches	0.6	1.1	3.0	-0.6	1.4	-1.7	0.3	0.1
Heart disease (mother)	0.3	0.4	1.0	0.4	0.1	-0.5	0.6	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.4	-2.3	-0.5	0.5	-0.1	1.3
Whole body fat mass	0.2	0.7	1.3	1.0	1.1	-0.5	-1.1	0.2
Leg fat mass (right)	0.1	0.5	1.4	1.2	0.2	-0.0	-1.0	0.4
Arm predicted mass (right)	0.2	1.0	3.6	0.4	-0.0	-0.3	-1.0	1.9
Pulse rate, automated reading	1.7	5.6	12.1	3.5	-2.7	2.0	-2.0	0.5
Alcohol intake frequency.	0.6	1.4	4.0	1.0	-1.0	0.0	2.0	0.9
Comparative height size at age 10	0.2	0.9	3.0	-1.7	-0.4	0.8	-0.7	0.1
Number of full sisters	2.0	2.4	5.5	1.2	0.6	0.3	2.3	2.2
Suffer from ‘nerves’	0.9	1.4	2.2	-1.3	-0.7	0.8	-1.5	-1.3
Overall health rating	0.7	1.6	3.9	0.6	-1.9	0.3	-2.0	-0.2
Chest pain or discomfort	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.3	0.4
Had major operations	0.9	1.1	4.2	1.1	-0.0	0.0	2.0	0.3
Age at last live birth	0.8	1.1	3.1	-1.8	-1.0	0.9	-0.2	-0.8
Family relationship satisfaction	0.9	1.1	4.5	0.1	-0.1	0.8	-2.1	-0.6
Leg pain on walking	0.7	0.9	3.2	-0.3	-0.6	-0.0	-1.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	2.8	0.8	-1.7	1.2	0.1	0.9
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.0	0.5	-2.0	1.9	-0.9	-1.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.9	0.7	-0.6	2.0	-0.7	1.1
Medication: Aspirin	1.0	1.4	3.5	1.9	0.6	-1.3	0.0	1.2
Supplements: Vitamin C	0.5	0.6	1.8	-0.3	-1.4	0.5	0.9	0.1
Knee pain experienced in last month	0.4	0.6	1.1	1.0	-0.2	0.4	1.0	-0.9
Hypertension (Self-reported)	2.0	5.5	15.8	4.0	-0.5	-2.1	-1.2	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	-0.4	-0.9	1.4	0.7	-0.4
Illnesses of father: Heart disease	1.6	2.2	5.1	-0.3	1.3	-2.3	-2.0	-0.7
Illnesses of siblings: Diabetes	1.6	2.0	3.2	1.1	1.4	-1.8	-1.8	0.8
Smoking status: Previous	0.5	0.7	2.5	1.6	0.8	-0.1	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	7.0	-2.6	1.8	0.2	0.4	-1.1
Whole body fat-free mass	0.2	0.9	3.2	-0.2	-0.8	0.3	-0.6	1.8
Leg fat-free mass (right)	0.1	0.4	0.9	-0.1	-0.9	0.5	-0.6	0.6
Arm fat percentage (left)	0.2	0.7	2.4	1.6	0.5	-0.2	-0.6	-0.4
Average weekly red wine intake	0.5	0.7	2.2	-0.5	-0.6	1.5	-0.7	-0.3
Handedness (chirality/laterality): Left-handed	1.5	1.8	5.1	0.5	2.3	-0.9	0.8	1.4
Mood swings	0.2	0.4	1.2	0.3	0.0	0.6	-1.1	-0.2
Loneliness, isolation	0.6	0.8	2.0	0.1	-1.4	-0.0	-0.5	-1.3
Long-standing illness, disability or infirmity	0.4	0.7	1.3	1.1	-0.9	-0.2	1.0	0.6
Ever had bowel cancer screening	1.1	1.3	2.7	-1.2	0.3	-0.9	-1.6	1.2
Diabetes diagnosed by doctor	0.2	0.3	0.9	0.3	-0.1	-0.5	-0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.3	-0.5	-2.1	1.6	1.0	-1.1
Friendships satisfaction	0.7	0.8	2.1	1.5	-0.3	0.7	-1.2	0.5
Qualifications: nursing, teaching	0.8	1.2	2.1	-1.5	1.0	1.3	-0.2	1.0
Commuting to job workplace: Walk	1.3	1.4	4.2	-0.5	2.1	-1.2	0.9	0.6
Eye problems/disorders: Cataract	0.4	0.4	0.7	-0.4	0.8	-0.7	-0.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.4	0.6	-0.4	-0.7	0.0	2.1
Medication for cholesterol	1.3	2.0	6.5	-2.6	0.0	1.2	-1.0	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.3	1.4	-1.2	0.3	-1.8	-0.9
Back pain experienced in last month	0.4	0.5	1.3	0.2	-1.1	0.3	0.8	-0.7
Mineral and other dietary supplements	1.6	2.1	3.6	0.8	1.7	-1.8	1.9	-0.2
Breast cancer (self-reported)	0.4	0.4	1.3	-0.2	0.8	-0.2	1.1	0.3
Asthma (self-reported)	0.8	1.5	3.6	-1.9	1.6	0.3	1.0	0.5
Osteoporosis (self-reported)	0.3	0.3	1.3	-0.4	-1.1	0.0	0.0	0.4
Osteoarthritis (self-reported)	0.5	0.7	1.4	0.6	-0.4	0.4	1.2	1.1
Medication: Aspirin	0.7	1.0	2.2	1.5	0.5	-1.3	0.2	0.8
Medication: Gliclazide	1.3	1.5	3.0	1.3	-0.4	-1.5	-0.6	1.7
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	0.4	0.5	-0.0	1.0	0.1
Smoking status: Current	0.6	1.0	2.6	0.6	-0.5	1.6	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.3	18.3	1.0	-4.3	3.3	-0.9	0.4
Whole body water mass	0.2	0.9	3.2	-0.0	-0.8	0.2	-0.7	1.8
Leg predicted mass (right)	0.1	0.4	0.9	-0.1	-0.9	0.5	-0.5	0.7
Arm fat mass (left)	0.1	0.5	1.8	1.4	0.2	-0.1	-0.8	0.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.1	1.8	-1.4	1.1	-1.0	0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.8	-0.9	-0.5	0.4	-0.3	0.9
Miserableness	1.2	2.0	3.8	-1.0	-1.3	0.6	-1.8	-1.9
Guilty feelings	0.8	1.2	4.0	2.0	-0.1	0.7	-0.5	1.2
Wears glasses or contact lenses	1.1	1.3	3.8	1.0	0.7	1.0	1.9	0.3
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.4	0.6	-0.0	-0.1	-1.0
Hearing aid user	1.3	1.5	3.4	0.7	-1.9	1.2	-0.6	1.2
Mother’s age at death	1.0	1.3	5.9	-2.4	0.4	-0.4	0.3	-0.5
Financial situation satisfaction	0.3	0.4	0.8	0.6	0.5	-0.8	-0.2	0.9
Tinnitus: Yes, now most or all of the time	1.4	1.6	5.6	1.2	0.2	-0.9	0.3	2.4
Commuting to job workplace: Public transport	0.9	1.1	3.5	-1.0	1.9	-0.6	0.2	-0.7
Eye problems/disorders: Glaucoma	1.8	2.1	4.1	-0.4	-2.0	2.0	-1.0	-1.1
Medication: Blood pressure	1.3	2.5	8.3	2.9	-0.1	-0.7	0.2	1.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.2	1.5	-0.7	0.6	0.5	0.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	3.0	-0.8	-1.0	1.7	-0.4	0.1
High cholesterol (Self-reported)	0.7	1.3	6.1	2.5	-0.5	0.3	-0.2	0.2
Medication: Bendroflumethiazide	1.1	1.6	3.9	2.0	-0.0	-0.8	0.3	1.9
Medication: Paracetamol	2.3	3.6	8.4	2.9	-2.6	1.5	0.7	0.1
Medication: Lisinopril	0.6	0.8	1.3	1.0	-0.5	1.0	0.7	-1.1
Medication: Atorvastatin	0.8	1.0	2.2	1.5	-0.5	1.1	1.2	0.4
Illnesses of father: High blood pressure	1.4	1.8	6.0	0.7	-2.4	1.4	-0.7	0.3
Alcohol drinker status: Never	0.5	0.6	0.9	-0.8	-0.6	-0.5	1.0	-0.9
Ever smoked	0.2	0.4	0.6	0.8	0.4	0.7	-0.5	-0.8
Basal metabolic rate	0.1	0.6	2.4	-0.1	-0.5	0.2	-0.6	1.6
Leg fat percentage (left)	0.2	0.8	2.7	1.6	0.4	-0.2	-0.8	0.8
Arm fat-free mass (left)	0.2	1.2	4.6	0.3	-0.4	0.2	-0.9	2.2
Number of operations (self-reported)	1.1	1.6	5.9	2.4	-0.9	-0.8	0.7	-0.3
Average weekly beer plus cider intake	0.7	1.0	1.6	-0.1	-1.3	1.2	1.2	0.8
Irritability	0.3	0.6	1.4	0.3	0.2	1.1	-1.2	0.3
Risk taking	1.0	1.5	4.2	1.6	0.1	0.2	-2.1	0.8
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.9	-0.8	-0.8	0.9	-1.3	1.4
Fractured/broken bones in last 5 years	0.9	1.1	2.0	0.8	1.2	-1.1	0.4	-1.4
Age started oral contraceptive pill	0.5	0.7	1.2	0.7	0.7	-0.5	-1.1	-0.9
Diastolic blood pressure, automated reading	3.9	12.0	30.6	4.6	-5.5	1.9	-1.9	-0.7
Ever depressed for a whole week	0.5	0.6	2.0	-0.7	0.8	-1.4	-0.2	-0.1
Unable to work because of sickness or disability	0.5	0.7	2.8	0.1	0.0	-0.8	0.3	-1.7
Commuting to job workplace: Cycle	0.6	0.8	1.7	-0.1	0.9	1.1	1.3	0.5
Myopia	0.8	1.2	4.4	-0.2	0.1	0.4	-1.1	2.1
Vascular/heart problems diagnosed by doctor	1.7	4.7	15.6	-4.0	0.6	1.3	0.4	-2.4
Cholesterol lowering medication	0.3	0.4	1.3	1.1	-0.3	-0.4	0.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.4	1.2	-0.0	0.1	-1.4
Pain experienced in last month	1.3	2.2	4.9	-1.7	1.8	-0.3	-2.2	0.1
Supplements: Calcium	0.8	0.8	2.0	0.5	0.8	-1.1	-0.1	1.4
Basal cell carcinoma (self-reported)	0.8	1.0	3.5	1.9	0.6	0.1	0.9	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	-0.2	1.0	-0.5	-0.0	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.6	-1.0	0.5	-1.5	-1.0	-2.2
Heart disease (siblings)	0.6	0.8	2.5	0.5	1.0	-1.6	-0.3	-0.1
Alcohol drinker status: Previous	1.0	1.2	1.9	1.4	-1.3	1.3	0.0	0.7
Pack years of smoking	0.7	1.0	2.4	1.6	-1.1	0.9	-0.5	-0.6
Impedance of whole body	0.8	4.1	8.8	-1.7	3.0	-1.5	1.2	-2.3
Leg fat mass (left)	0.2	0.6	1.5	1.2	0.3	-0.1	-1.0	0.6
Arm predicted mass (left)	0.2	1.0	4.1	0.2	-0.4	0.3	-0.9	2.0