Hub : Genes

THSD4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.034 0.020 2.9e-02 0.005 0.002 0.007 0.004 0.002 7.8e-02 0.16 4.6e-02 0.1 1.7e-01
2 GTEx Artery Aorta 0.239 0.064 4.9e-05 0.102 NA 0.081 NA 0.085 3.0e-06 NA 3.1e-05 NA 2.0e-05
3 GTEx Esophagus Gastroesophageal Junction 0.242 0.084 2.5e-03 0.018 NA -0.007 NA 0.003 7.1e-02 NA 6.8e-01 NA 2.5e-01
4 GTEx Stomach 0.231 0.080 2.8e-03 -0.003 NA -0.006 NA -0.005 4.5e-01 NA 8.2e-01 NA 6.5e-01
5 GTEx Testis 0.432 0.122 3.5e-03 0.064 NA 0.023 NA 0.126 8.8e-04 NA 3.3e-02 NA 3.3e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.5 3.8 -1.0 0.3 -0.4 -1.6 -2.0
Bipolar Disorder or Schizophrenia 1.0 2.5 4.7 -1.7 0.8 0.1 -2.2 -2.1
Depressed Affect (Nagel 2018) 0.3 0.7 1.3 -0.3 -0.9 0.4 -1.1 -0.9
Depression (Nagel 2018) 0.1 0.2 0.7 -0.8 0.2 -0.3 -0.1 -0.5
Intelligence (Savage-Jansen 2018) 0.3 1.0 4.1 0.5 -0.2 -2.0 -0.4 0.5
Neuroticism (Nagel 2018) 0.3 0.8 2.3 0.6 -0.9 1.5 -0.7 -0.3
Schizophrenia (2018) 0.6 1.3 2.0 -1.4 0.8 0.4 -1.4 -1.3
Schizophrenia vs Biploar Disorder 1.0 1.3 3.3 -0.2 -1.1 1.2 -0.8 1.8
Worry (Nagel 2018) 0.3 0.6 1.3 0.4 -0.9 1.1 -0.9 -0.1
Alzheimer’s Disease (in mother) 0.4 0.4 1.3 0.8 0.4 -0.2 0.2 1.1
Alzheimer’s Disease (in father) 0.4 0.4 0.9 -0.9 -0.7 0.0 -0.7 -0.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.4 -0.0 0.0 -0.5 0.5
Crohns Disease (2017) 0.2 0.4 1.5 -0.5 -0.2 0.2 1.2 0.4
Irritable Bowel Disease (IBD) 0.5 1.1 2.4 -0.6 1.3 -1.1 1.6 -0.1
Ulcerative Colitis (UC) 0.7 1.3 2.8 0.0 1.7 -1.6 1.1 -0.3
Major Depression (MDD) 0.5 0.6 1.8 -0.2 0.5 -0.2 0.9 1.4
Reaction Time 0.7 1.3 2.2 -1.3 1.0 -0.8 1.0 -1.5
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.7 0.4 -0.8 0.2 -0.7 0.5
Breast Cancer 0.3 0.6 1.5 1.0 1.2 -0.4 0.6 -0.3
Ovarian Cancer 0.8 1.1 3.7 -0.3 0.0 -1.2 -0.2 -1.9
Prostate Cancer 1.1 1.6 4.8 0.5 -1.4 0.6 0.8 2.2
Age at First Birth 0.4 0.6 1.3 -1.1 -0.4 -0.5 -1.1 -0.1
Bipolar Disorder (2011) 0.9 0.9 2.5 0.4 1.6 -1.3 0.1 0.5
Body Mass Index (BMI) (2010) 0.3 0.5 1.9 0.6 -0.0 1.4 -0.0 -0.3
Coronary Artery Disease (CAD) 0.4 0.5 1.7 -0.0 0.8 -0.5 0.2 -1.3
Crohns Disease (2012) 0.5 0.9 2.1 -0.5 -1.1 0.5 1.5 0.6
Mean Putamen Volume 1.5 1.8 3.9 -0.3 -2.0 1.8 1.1 -0.5
Fasting Glucose 0.5 0.6 1.9 -0.0 -0.4 0.2 1.4 0.8
HbA1C 1.0 1.1 4.2 0.2 2.0 -0.5 -0.6 0.7
HDL Cholesterol 0.4 0.6 2.1 -1.4 0.6 0.6 0.7 -0.0
LDL Cholesterol 0.1 0.2 0.8 -0.5 -0.2 0.3 0.9 0.0
Lupus 0.4 0.6 1.3 -1.1 0.7 -0.7 0.4 -0.8
Neuroticism (2016) 1.1 1.6 3.5 1.9 -0.2 -1.1 0.2 1.8
Primary Biliary Cirrhosis 0.4 0.6 1.9 -0.5 1.4 0.3 1.0 -0.3
Rheumatoid Arthritis 0.6 0.8 2.6 0.8 0.5 -0.6 0.6 1.6
Schizophrenia (2014) 0.4 1.0 2.9 -1.0 0.8 0.6 -1.7 -0.0
Triglycerides 0.4 0.7 1.4 1.2 -0.2 -1.1 -0.5 -0.9
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.4 1.2 -0.7 1.0 -0.8 0.2
Ulcerative Colitis 0.9 1.3 2.6 -1.1 1.6 -1.6 0.6 -0.1
Blood Eosinophil Count 0.2 1.8 4.0 0.8 -2.0 1.2 -1.7 0.2
Blood Platelet Count 0.1 1.6 5.0 -0.5 2.2 -1.2 -1.2 -0.4
Blood Red Count 0.6 5.6 15.7 2.8 4.0 -2.0 0.6 -0.1
Blood White Count 0.4 3.2 8.0 0.8 2.8 -1.6 1.2 1.9
Heel T-Score 0.8 6.3 23.7 -1.9 4.9 -1.7 -0.0 1.1
BMI 0.1 0.6 2.0 0.8 0.6 -0.1 -1.4 0.1
Height 0.2 4.5 10.9 -2.3 3.3 -1.9 0.6 1.5
Waist Hip Ratio (WHR) 0.7 3.3 5.6 2.2 2.3 -2.4 -0.8 0.8
Systolic Blood Pressure 0.8 3.8 13.7 3.7 0.4 -1.6 0.2 1.7
Smoking Status 0.4 0.8 2.7 1.7 0.6 1.0 -0.1 0.3
Allergy or Eczema 0.9 2.3 4.7 2.2 -2.0 1.2 0.6 1.0
Cardiovascular Disease 1.1 3.6 15.4 3.9 -0.7 -1.3 -0.4 0.5
Hypothyroidism (self reported) 0.2 0.5 1.1 0.8 0.5 -0.4 -1.1 -0.5
Respiratory disease 0.9 2.0 3.9 -2.0 1.9 -0.5 1.2 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.7 -0.6 0.8 -1.3 -0.6 -0.1
Lung FEV1/FVC ratio 68.6 347.9 1049.8 12.9 -32.4 21.6 -6.0 4.5
Lung FVC 1.2 5.9 22.5 -2.0 4.7 -1.4 0.9 -0.2
Neuroticism 0.3 0.7 1.1 1.0 -0.8 0.7 -1.1 0.3
Chronotype (morning person) 1.0 2.3 9.9 3.1 -0.2 -0.6 -0.3 1.1
Hair Pigment 0.0 0.7 1.0 0.9 -0.9 0.8 1.0 0.2
Tanning 0.1 1.4 3.6 -1.5 1.9 -0.4 0.8 0.8
Hand grip strength (left) 0.3 0.7 1.6 -1.0 1.3 -0.3 -0.7 0.6
Number of treatments/medications taken 1.4 2.6 6.7 2.6 -1.9 0.5 1.1 -1.0
Average weekly spirits intake 0.9 1.1 3.2 0.3 1.8 -0.1 1.4 -0.5
Sensitivity / hurt feelings 0.8 1.3 2.2 -0.3 -1.0 1.1 -1.5 -1.3
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.4 -0.3 0.9 -1.2 -0.1 0.1
Hearing difficulty/problems: Yes 0.3 0.4 0.9 0.7 -0.9 0.2 -0.8 -0.1
Relative age of first facial hair 1.0 2.0 5.0 -0.0 -0.1 1.2 2.2 1.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.6 0.0 -0.8 -0.5 0.2 -0.0
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.6 1.5 0.7 -0.5 -1.6 0.4
Ever had hysterectomy (womb removed) 0.4 0.4 1.0 0.3 0.6 -0.6 -0.4 1.0
Systolic blood pressure, automated reading 1.1 3.3 12.2 3.5 1.0 -1.3 0.1 1.3
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.7 1.3 -0.2 0.7 0.1 0.7
Angina 1.1 1.4 5.2 0.1 1.1 0.1 2.3 0.9
Medication for hormone replacement therapy 0.4 0.5 2.0 -0.0 -0.3 -0.4 1.4 -0.1
Vitamin and mineral supplements 0.3 0.4 1.4 -0.2 1.2 -0.5 -0.3 0.3
Supplements: Zinc 1.2 1.3 2.8 0.4 -1.7 1.4 -0.1 -1.3
Medication: Co-codamol 0.3 0.3 0.8 -0.5 0.6 0.2 0.9 0.4
Medication: Metformin 0.3 0.4 1.1 1.1 0.8 -0.5 -0.5 -0.2
Diabetes (father) 0.4 0.5 1.2 -1.1 0.7 0.4 0.4 -0.5
Diabetes (mother) 0.9 1.1 2.5 -1.3 1.6 -0.4 1.1 -0.3
Severe depression (siblings) 1.2 1.3 2.5 -1.6 1.2 -0.5 -0.3 1.5
Pack years adult smoking proportion 0.8 1.2 2.5 1.6 -1.3 1.2 -0.6 -0.5
Impedance of leg (right) 0.7 3.3 10.4 -1.1 3.2 -1.6 1.2 -0.8
Leg fat-free mass (left) 0.1 0.3 0.5 -0.2 -0.7 0.5 -0.5 0.5
Trunk fat percentage 0.4 1.5 4.8 0.9 2.2 -1.1 -0.7 -0.2
Hand grip strength (right) 0.6 1.6 4.7 -2.2 -0.0 0.7 -1.1 -1.2
Townsend deprivation index at recruitment 0.2 0.3 0.6 -0.2 0.7 -0.8 -0.0 0.6
Current tobacco smoking 0.5 0.9 2.5 0.9 -0.5 1.6 0.4 0.8
Average weekly fortified wine intake 1.3 1.6 5.0 -2.2 1.6 -0.3 0.3 0.1
Maternal smoking around birth 0.4 0.5 0.8 0.9 0.7 -0.8 -0.7 0.5
Fed-up feelings 0.5 0.9 1.7 0.8 -0.7 0.6 -1.3 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.4 -0.0 0.5 -0.2 0.7 -0.7
Relative age voice broke 1.0 1.5 4.8 -0.0 0.9 -0.3 2.2 1.4
Taking other prescription medications 0.6 0.9 2.8 1.7 -0.6 1.1 0.1 -0.2
Age when periods started (menarche) 0.2 0.4 0.9 -0.9 0.0 0.0 -0.4 -0.9
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 3.1 0.8 -0.2 0.4 -0.4 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.0 -0.6 1.0 0.3 0.3 0.4
Tinnitus: Yes, but not now, but have in the past 1.1 1.1 2.1 1.1 -0.2 -1.4 -1.0 1.2
Qualifications: CSEs or equivalent 0.6 0.8 2.3 0.4 -1.5 0.6 0.6 -0.7
Serious illness, injury or assault to yourself 0.9 1.0 2.9 0.3 1.1 -1.7 0.7 -0.6
High blood pressure 2.1 5.8 18.7 4.3 -0.4 -1.6 -0.6 2.7
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.5 1.9 -1.2 0.5 0.0 0.3
Multivitamins +/- minerals 0.4 0.5 1.6 -0.0 -0.8 -0.1 -1.3 -0.3
Stomach or abdominal pain in last month 1.7 2.1 5.9 0.1 -2.4 1.5 -1.0 -1.1
Supplements: Glucosamine 2.5 3.3 8.0 -1.9 -1.2 1.6 -2.8 -1.0
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.0 1.0 0.2 -0.0 -0.1 -0.2
Medication: Atenolol 0.0 0.0 0.1 -0.2 0.0 -0.2 -0.2 0.3
Medication: Levothyroxine sodium 0.3 0.5 1.3 0.3 1.1 -0.2 0.8 -0.8
Sitting height 0.2 1.1 2.0 -1.3 0.4 -0.2 1.4 1.3
Chronic bronchitis/emphysema (father) 0.9 1.0 1.5 -1.2 1.1 -0.2 -1.1 -1.2
High blood pressure (mother) 1.5 2.1 7.6 0.4 -2.8 1.6 -0.3 0.1
Body mass index (BMI) 0.3 1.2 3.5 1.9 -0.6 0.5 -1.2 0.8
Impedance of leg (left) 0.6 3.1 10.4 -0.9 3.2 -1.7 1.1 -0.4
Leg predicted mass (left) 0.1 0.3 0.6 -0.1 -0.8 0.5 -0.5 0.5
Trunk fat mass 0.2 0.9 1.9 0.9 1.4 -0.8 -0.9 0.3
Waist circumference 0.4 1.4 4.9 2.2 0.9 -0.4 0.2 1.1
Number of incorrect matches in round 0.3 0.5 1.6 0.3 0.4 0.1 -0.9 -1.3
Past tobacco smoking 0.5 0.8 3.1 -1.7 -0.0 -1.0 0.2 0.5
Alcohol usually taken with meals 0.8 1.2 2.7 -1.6 1.5 -0.6 0.3 0.8
Nervous feelings 0.2 0.3 0.8 -0.0 -0.9 0.8 0.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 -0.2 -0.1 0.2 -1.3 -0.7
Hearing difficulty/problems with background noise 0.3 0.5 0.9 -0.4 0.5 -0.8 -1.0 -0.6
Hair/balding pattern: Pattern 2 1.3 1.6 4.8 0.8 -1.4 2.2 0.1 0.8
Had menopause 0.2 0.2 0.6 -0.2 0.6 -0.2 0.1 -0.8
Had other major operations 1.4 1.7 4.6 1.1 -2.1 1.7 0.5 -0.0
Forced vital capacity (FVC) 1.3 4.9 10.9 -3.2 3.3 -1.3 1.3 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.0 -1.4 0.9 0.6 0.1 -1.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.0 -1.1 1.4 -1.0 1.4 -0.7
Qualifications: None of the above 1.0 2.2 5.9 2.4 -0.9 -0.6 1.4 1.5
Financial difficulties in last 2 years 0.3 0.4 1.0 0.1 0.0 0.2 -0.9 -1.0
Mouth/teeth dental problems 0.2 0.2 1.1 0.2 -0.2 -0.1 -1.0 0.2
Heart attack 0.2 0.2 0.9 -0.1 0.9 -0.4 0.2 -0.1
Allergy 0.2 0.5 1.1 -0.7 -0.5 0.6 -1.0 -0.7
Pain all over the body in last month 0.4 0.4 1.5 -1.2 -0.0 -0.0 -0.2 -0.6
Diabetes (self-reported) 0.3 0.5 2.0 -0.1 -0.4 -0.3 -1.4 0.2
Hayfever/allergic rhinitis (self-reported) 2.6 3.4 6.8 2.6 -2.5 1.2 -0.8 1.4
Medication: Ramipril 2.1 2.7 5.1 2.2 0.7 -2.2 -1.2 1.4
Medication: Simvastatin 0.7 1.0 3.2 1.8 -0.5 -0.6 -0.4 0.9
Fluid intelligence score 0.2 0.5 0.7 0.9 -0.6 -0.7 -0.5 -0.7
Illnesses of siblings 1.3 1.8 3.0 -1.5 -0.2 1.4 1.7 -1.2
Neuroticism score 0.3 0.7 1.4 0.6 -0.9 0.8 -1.2 -0.5
Weight 0.1 0.4 1.1 0.3 0.2 -0.2 -1.1 0.8
Impedance of arm (right) 0.6 2.6 4.3 -1.5 2.0 -0.9 1.4 -2.1
Arm fat percentage (right) 0.2 0.6 2.8 1.7 0.3 0.0 -0.4 0.2
Trunk fat-free mass 0.2 1.4 5.0 -0.4 -1.1 0.4 -0.7 2.2
Hip circumference 0.1 0.3 0.9 -0.3 -0.3 0.5 1.0 0.3
Time employed in main current job 1.6 1.9 6.1 -2.5 0.9 -0.7 -0.1 -1.4
Alcohol intake versus 10 years previously 0.2 0.4 1.0 0.1 -1.0 0.3 0.2 -0.8
Father’s age at death 0.7 1.0 1.7 -1.1 1.3 -1.1 0.7 -0.6
Worrier / anxious feelings 0.4 0.8 3.0 0.4 -0.3 0.3 -1.7 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.2 -0.8 -0.3 -0.3 -0.5
Falls in the last year 0.8 1.1 2.0 -0.9 1.1 -1.1 -0.2 -1.4
Hair/balding pattern: Pattern 3 1.5 2.3 3.9 -1.5 1.1 -1.9 0.8 -2.0
Number of live births 0.6 0.9 2.0 -1.4 -0.5 0.1 1.0 -1.1
Forced expiratory volume in 1-second (FEV1) 2.7 9.0 27.4 -0.1 -5.2 4.1 -0.7 0.7
Pulse rate 1.2 2.0 4.4 1.1 -1.9 0.5 -2.1 -0.8
Happiness 0.6 0.7 2.1 -0.6 0.5 -0.2 -0.9 -1.5
Noisy workplace 0.2 0.2 1.0 -0.1 -0.0 0.4 0.1 -1.0
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.3 0.3 -0.7 -0.6 -1.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.6 -1.2 1.0 -0.8 -0.4 -0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.6 0.1 -0.2 0.7 -0.2 -0.8
Asthma 0.7 1.4 3.1 -1.7 1.7 0.3 0.8 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 4.2 1.0 -2.0 0.5 1.9 -0.6
Medication: Cholesterol lowering 0.6 0.9 2.4 1.5 0.7 -0.9 -0.5 0.9
Depression (self-reported) 0.6 0.7 1.7 -0.0 -0.9 1.3 0.1 0.9
Medication: Lansoprazole 0.4 0.4 1.2 1.1 0.3 0.9 -0.3 0.2
Prospective memory result 1.5 1.9 7.2 -2.7 0.9 -0.8 0.3 -0.9
Lung cancer (father) 2.6 3.0 8.1 0.4 -2.2 2.8 -1.4 -0.3
Illnesses of mother 0.4 0.5 1.9 0.6 1.4 0.4 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 3.5 11.2 34.9 0.1 -5.9 4.6 -0.4 0.3
Pulse wave Arterial Stiffness index 1.0 1.2 2.8 -0.3 1.4 -0.3 1.1 1.7
Impedance of arm (left) 0.8 3.9 9.0 -1.8 2.2 -1.1 1.1 -3.0
Arm fat mass (right) 0.1 0.5 1.6 1.3 0.3 -0.1 -0.7 0.4
Trunk predicted mass 0.2 1.4 4.7 -0.3 -1.1 0.5 -0.7 2.2
Standing height 0.3 2.7 9.2 -3.0 1.7 -1.2 0.3 0.3
Length of working week for main job 1.0 1.1 4.5 2.1 -0.3 0.0 -0.9 -0.2
Exposure to tobacco smoke at home 1.4 1.6 4.4 0.9 1.1 -0.7 1.0 2.1
Breastfed as a baby 0.8 1.0 2.4 0.6 1.3 -1.6 -0.6 0.5
Tense / ‘highly strung’ 0.2 0.4 0.6 0.8 0.3 -0.6 0.8 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.0 -0.2 -1.0 0.8 -0.4 0.2
Hair/balding pattern: Pattern 4 0.8 2.0 4.8 1.3 -2.2 1.8 -0.1 -0.7
Birth weight of first child 1.0 1.8 5.3 0.6 1.2 -2.3 -0.2 1.2
Peak expiratory flow (PEF) 9.2 21.4 68.5 1.7 -8.3 5.7 -1.4 1.3
Pulse wave reflection index 1.2 1.5 3.6 0.2 1.1 -0.8 1.9 1.3
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.5 0.5 0.7 -0.7 1.1 -1.6
Loud music exposure frequency 0.4 0.5 1.4 0.1 -0.3 0.7 0.5 -1.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.9 -0.4 0.3 0.0 -1.2 -1.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 5.5 -2.3 0.7 0.6 1.3 -1.4
Blood clot in the leg (DVT) 1.5 1.9 4.1 -0.7 0.7 -1.9 -0.9 -2.0
Medication: Paracetamol 1.8 3.0 6.6 2.6 -2.4 1.4 0.8 0.4
Headache pain in last month 2.6 4.5 9.6 3.0 -3.1 1.1 1.4 -0.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.1 -1.8 0.0 1.1 0.7 -0.6
Glaucoma (self-reported) 0.8 1.0 1.9 -0.6 -1.4 1.1 -0.5 -1.0
Gout (self-reported) 0.5 0.7 2.2 1.5 0.8 -0.3 0.6 -0.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 0.4 0.4 -0.4 -0.2 -0.7
Medication: Amlodipine 2.0 2.7 7.4 2.5 0.0 -0.4 0.2 2.7
Medication: Ventolin 100micrograms inhaler 1.2 1.5 3.9 -0.9 2.0 0.6 1.4 0.8
Birth weight 0.0 0.1 0.3 0.2 0.6 -0.1 0.1 -0.2
Chronic bronchitis/emphysema (mother) 2.0 2.3 5.7 -2.4 1.4 -1.7 1.1 -0.1
High blood pressure (siblings) 0.9 1.3 2.2 1.5 -1.4 -0.3 -1.1 1.1
Forced vital capacity (FVC), Best measure 1.1 4.2 9.1 -3.0 2.8 -1.3 1.1 -0.9
Body fat percentage 0.3 1.0 2.7 1.2 1.6 -0.7 -0.8 -0.2
Leg fat percentage (right) 0.2 0.7 2.7 1.6 0.4 -0.1 -0.6 0.5
Arm fat-free mass (right) 0.2 1.0 3.6 0.4 0.1 -0.2 -1.0 1.9
Exposure to tobacco smoke outside home 0.7 0.9 2.0 -0.2 1.1 -1.0 -1.4 -0.7
Comparative body size at age 10 0.3 0.7 2.4 0.4 -1.5 0.4 -0.5 -0.7
Number of full brothers 0.7 0.9 2.0 0.5 0.7 -1.4 1.0 0.8
Worry too long after embarrassment 0.5 0.8 2.6 0.2 -0.7 1.6 -0.3 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 3.1 0.9 -1.8 1.0 -0.4 0.7
Wheeze or whistling in the chest in last year 0.9 1.6 5.2 -1.4 2.3 -0.4 0.4 0.5
Number of children fathered 0.4 0.4 1.7 1.3 -0.5 0.1 0.2 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.8 0.4 0.7 -0.4 -0.7 2.2
Age at first live birth 1.3 2.3 6.4 -2.5 -0.5 0.5 -1.2 -1.8
Pulse wave peak to peak time 1.0 1.2 3.2 -0.1 -1.2 0.3 -1.2 -1.8
Health satisfaction 1.0 1.3 4.2 1.1 -0.7 -0.6 -2.0 -0.0
Shortness of breath walking on level ground 0.3 0.3 0.8 0.7 0.7 -0.2 -0.9 0.0
Qualifications: College or University degree 0.3 1.0 3.0 -0.7 -0.1 1.1 -1.7 0.0
Eye problems/disorders: None of the above 0.4 0.4 1.7 1.3 -0.0 0.1 0.7 0.1
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.4 -1.2 0.2 -0.7 0.1 -0.2
Emphysema/chronic bronchitis 1.1 1.3 3.7 0.5 1.4 -1.9 0.7 0.2
Medication for pain relief, constipation, heartburn 1.5 2.5 6.6 -2.6 2.1 -0.1 -0.7 0.9
Neck or shoulder pain in last month 1.0 1.5 4.2 2.1 -0.6 -0.6 0.2 1.5
Medication: Blood pressure 0.7 1.2 2.7 1.6 -0.1 -1.1 -1.2 0.8
Angina (self-reported) 0.9 1.2 4.1 0.1 1.1 0.1 2.0 0.8
Migraine (self-reported) 1.9 2.4 4.9 2.2 -1.6 1.4 1.0 1.3
Medication: Ibuprofen 2.1 2.5 7.3 1.6 -1.5 -0.1 2.7 -0.6
Medication: Allopurinol 0.4 0.5 1.4 1.2 0.1 -0.3 -0.9 -0.1
Medication: Omeprazole 0.5 0.6 1.7 -0.3 1.1 -0.3 0.4 -1.3
Medication: Seretide 50 evohaler 1.3 1.5 4.4 -0.4 2.1 -1.6 0.4 -0.6
Mean time to correctly identify matches 0.6 1.1 3.0 -0.6 1.4 -1.7 0.3 0.1
Heart disease (mother) 0.3 0.4 1.0 0.4 0.1 -0.5 0.6 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 5.4 -2.3 -0.5 0.5 -0.1 1.3
Whole body fat mass 0.2 0.7 1.3 1.0 1.1 -0.5 -1.1 0.2
Leg fat mass (right) 0.1 0.5 1.4 1.2 0.2 -0.0 -1.0 0.4
Arm predicted mass (right) 0.2 1.0 3.6 0.4 -0.0 -0.3 -1.0 1.9
Pulse rate, automated reading 1.7 5.6 12.1 3.5 -2.7 2.0 -2.0 0.5
Alcohol intake frequency. 0.6 1.4 4.0 1.0 -1.0 0.0 2.0 0.9
Comparative height size at age 10 0.2 0.9 3.0 -1.7 -0.4 0.8 -0.7 0.1
Number of full sisters 2.0 2.4 5.5 1.2 0.6 0.3 2.3 2.2
Suffer from ‘nerves’ 0.9 1.4 2.2 -1.3 -0.7 0.8 -1.5 -1.3
Overall health rating 0.7 1.6 3.9 0.6 -1.9 0.3 -2.0 -0.2
Chest pain or discomfort 0.1 0.1 0.2 -0.3 0.4 -0.2 -0.3 0.4
Had major operations 0.9 1.1 4.2 1.1 -0.0 0.0 2.0 0.3
Age at last live birth 0.8 1.1 3.1 -1.8 -1.0 0.9 -0.2 -0.8
Family relationship satisfaction 0.9 1.1 4.5 0.1 -0.1 0.8 -2.1 -0.6
Leg pain on walking 0.7 0.9 3.2 -0.3 -0.6 -0.0 -1.8 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.1 2.8 0.8 -1.7 1.2 0.1 0.9
Commuting to job workplace: Car/motor vehicle 1.9 2.2 4.0 0.5 -2.0 1.9 -0.9 -1.6
Illness, injury, bereavement, stress in last 2 years 1.1 1.3 3.9 0.7 -0.6 2.0 -0.7 1.1
Medication: Aspirin 1.0 1.4 3.5 1.9 0.6 -1.3 0.0 1.2
Supplements: Vitamin C 0.5 0.6 1.8 -0.3 -1.4 0.5 0.9 0.1
Knee pain experienced in last month 0.4 0.6 1.1 1.0 -0.2 0.4 1.0 -0.9
Hypertension (Self-reported) 2.0 5.5 15.8 4.0 -0.5 -2.1 -1.2 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.1 -0.4 -0.9 1.4 0.7 -0.4
Illnesses of father: Heart disease 1.6 2.2 5.1 -0.3 1.3 -2.3 -2.0 -0.7
Illnesses of siblings: Diabetes 1.6 2.0 3.2 1.1 1.4 -1.8 -1.8 0.8
Smoking status: Previous 0.5 0.7 2.5 1.6 0.8 -0.1 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 7.0 -2.6 1.8 0.2 0.4 -1.1
Whole body fat-free mass 0.2 0.9 3.2 -0.2 -0.8 0.3 -0.6 1.8
Leg fat-free mass (right) 0.1 0.4 0.9 -0.1 -0.9 0.5 -0.6 0.6
Arm fat percentage (left) 0.2 0.7 2.4 1.6 0.5 -0.2 -0.6 -0.4
Average weekly red wine intake 0.5 0.7 2.2 -0.5 -0.6 1.5 -0.7 -0.3
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.1 0.5 2.3 -0.9 0.8 1.4
Mood swings 0.2 0.4 1.2 0.3 0.0 0.6 -1.1 -0.2
Loneliness, isolation 0.6 0.8 2.0 0.1 -1.4 -0.0 -0.5 -1.3
Long-standing illness, disability or infirmity 0.4 0.7 1.3 1.1 -0.9 -0.2 1.0 0.6
Ever had bowel cancer screening 1.1 1.3 2.7 -1.2 0.3 -0.9 -1.6 1.2
Diabetes diagnosed by doctor 0.2 0.3 0.9 0.3 -0.1 -0.5 -0.9 0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.3 -0.5 -2.1 1.6 1.0 -1.1
Friendships satisfaction 0.7 0.8 2.1 1.5 -0.3 0.7 -1.2 0.5
Qualifications: nursing, teaching 0.8 1.2 2.1 -1.5 1.0 1.3 -0.2 1.0
Commuting to job workplace: Walk 1.3 1.4 4.2 -0.5 2.1 -1.2 0.9 0.6
Eye problems/disorders: Cataract 0.4 0.4 0.7 -0.4 0.8 -0.7 -0.4 0.8
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.4 0.6 -0.4 -0.7 0.0 2.1
Medication for cholesterol 1.3 2.0 6.5 -2.6 0.0 1.2 -1.0 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 3.3 1.4 -1.2 0.3 -1.8 -0.9
Back pain experienced in last month 0.4 0.5 1.3 0.2 -1.1 0.3 0.8 -0.7
Mineral and other dietary supplements 1.6 2.1 3.6 0.8 1.7 -1.8 1.9 -0.2
Breast cancer (self-reported) 0.4 0.4 1.3 -0.2 0.8 -0.2 1.1 0.3
Asthma (self-reported) 0.8 1.5 3.6 -1.9 1.6 0.3 1.0 0.5
Osteoporosis (self-reported) 0.3 0.3 1.3 -0.4 -1.1 0.0 0.0 0.4
Osteoarthritis (self-reported) 0.5 0.7 1.4 0.6 -0.4 0.4 1.2 1.1
Medication: Aspirin 0.7 1.0 2.2 1.5 0.5 -1.3 0.2 0.8
Medication: Gliclazide 1.3 1.5 3.0 1.3 -0.4 -1.5 -0.6 1.7
Illnesses of father: None of the above (group 1) 0.2 0.3 0.9 0.4 0.5 -0.0 1.0 0.1
Smoking status: Current 0.6 1.0 2.6 0.6 -0.5 1.6 0.8 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.0 6.3 18.3 1.0 -4.3 3.3 -0.9 0.4
Whole body water mass 0.2 0.9 3.2 -0.0 -0.8 0.2 -0.7 1.8
Leg predicted mass (right) 0.1 0.4 0.9 -0.1 -0.9 0.5 -0.5 0.7
Arm fat mass (left) 0.1 0.5 1.8 1.4 0.2 -0.1 -0.8 0.3
Number of self-reported non-cancer illnesses 0.9 1.6 3.1 1.8 -1.4 1.1 -1.0 0.8
Average weekly champagne plus white wine intake 0.3 0.4 0.8 -0.9 -0.5 0.4 -0.3 0.9
Miserableness 1.2 2.0 3.8 -1.0 -1.3 0.6 -1.8 -1.9
Guilty feelings 0.8 1.2 4.0 2.0 -0.1 0.7 -0.5 1.2
Wears glasses or contact lenses 1.1 1.3 3.8 1.0 0.7 1.0 1.9 0.3
Ever taken oral contraceptive pill 0.3 0.3 0.9 0.4 0.6 -0.0 -0.1 -1.0
Hearing aid user 1.3 1.5 3.4 0.7 -1.9 1.2 -0.6 1.2
Mother’s age at death 1.0 1.3 5.9 -2.4 0.4 -0.4 0.3 -0.5
Financial situation satisfaction 0.3 0.4 0.8 0.6 0.5 -0.8 -0.2 0.9
Tinnitus: Yes, now most or all of the time 1.4 1.6 5.6 1.2 0.2 -0.9 0.3 2.4
Commuting to job workplace: Public transport 0.9 1.1 3.5 -1.0 1.9 -0.6 0.2 -0.7
Eye problems/disorders: Glaucoma 1.8 2.1 4.1 -0.4 -2.0 2.0 -1.0 -1.1
Medication: Blood pressure 1.3 2.5 8.3 2.9 -0.1 -0.7 0.2 1.9
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.2 1.5 -0.7 0.6 0.5 0.5
Supplements: Fish oil (including cod liver oil) 0.7 0.9 3.0 -0.8 -1.0 1.7 -0.4 0.1
High cholesterol (Self-reported) 0.7 1.3 6.1 2.5 -0.5 0.3 -0.2 0.2
Medication: Bendroflumethiazide 1.1 1.6 3.9 2.0 -0.0 -0.8 0.3 1.9
Medication: Paracetamol 2.3 3.6 8.4 2.9 -2.6 1.5 0.7 0.1
Medication: Lisinopril 0.6 0.8 1.3 1.0 -0.5 1.0 0.7 -1.1
Medication: Atorvastatin 0.8 1.0 2.2 1.5 -0.5 1.1 1.2 0.4
Illnesses of father: High blood pressure 1.4 1.8 6.0 0.7 -2.4 1.4 -0.7 0.3
Alcohol drinker status: Never 0.5 0.6 0.9 -0.8 -0.6 -0.5 1.0 -0.9
Ever smoked 0.2 0.4 0.6 0.8 0.4 0.7 -0.5 -0.8
Basal metabolic rate 0.1 0.6 2.4 -0.1 -0.5 0.2 -0.6 1.6
Leg fat percentage (left) 0.2 0.8 2.7 1.6 0.4 -0.2 -0.8 0.8
Arm fat-free mass (left) 0.2 1.2 4.6 0.3 -0.4 0.2 -0.9 2.2
Number of operations (self-reported) 1.1 1.6 5.9 2.4 -0.9 -0.8 0.7 -0.3
Average weekly beer plus cider intake 0.7 1.0 1.6 -0.1 -1.3 1.2 1.2 0.8
Irritability 0.3 0.6 1.4 0.3 0.2 1.1 -1.2 0.3
Risk taking 1.0 1.5 4.2 1.6 0.1 0.2 -2.1 0.8
Ever had prostate specific antigen (PSA) test 1.0 1.2 1.9 -0.8 -0.8 0.9 -1.3 1.4
Fractured/broken bones in last 5 years 0.9 1.1 2.0 0.8 1.2 -1.1 0.4 -1.4
Age started oral contraceptive pill 0.5 0.7 1.2 0.7 0.7 -0.5 -1.1 -0.9
Diastolic blood pressure, automated reading 3.9 12.0 30.6 4.6 -5.5 1.9 -1.9 -0.7
Ever depressed for a whole week 0.5 0.6 2.0 -0.7 0.8 -1.4 -0.2 -0.1
Unable to work because of sickness or disability 0.5 0.7 2.8 0.1 0.0 -0.8 0.3 -1.7
Commuting to job workplace: Cycle 0.6 0.8 1.7 -0.1 0.9 1.1 1.3 0.5
Myopia 0.8 1.2 4.4 -0.2 0.1 0.4 -1.1 2.1
Vascular/heart problems diagnosed by doctor 1.7 4.7 15.6 -4.0 0.6 1.3 0.4 -2.4
Cholesterol lowering medication 0.3 0.4 1.3 1.1 -0.3 -0.4 0.6 0.3
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.9 -0.4 1.2 -0.0 0.1 -1.4
Pain experienced in last month 1.3 2.2 4.9 -1.7 1.8 -0.3 -2.2 0.1
Supplements: Calcium 0.8 0.8 2.0 0.5 0.8 -1.1 -0.1 1.4
Basal cell carcinoma (self-reported) 0.8 1.0 3.5 1.9 0.6 0.1 0.9 -0.5
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.0 -0.2 1.0 -0.5 -0.0 -0.0
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 4.6 -1.0 0.5 -1.5 -1.0 -2.2
Heart disease (siblings) 0.6 0.8 2.5 0.5 1.0 -1.6 -0.3 -0.1
Alcohol drinker status: Previous 1.0 1.2 1.9 1.4 -1.3 1.3 0.0 0.7
Pack years of smoking 0.7 1.0 2.4 1.6 -1.1 0.9 -0.5 -0.6
Impedance of whole body 0.8 4.1 8.8 -1.7 3.0 -1.5 1.2 -2.3
Leg fat mass (left) 0.2 0.6 1.5 1.2 0.3 -0.1 -1.0 0.6
Arm predicted mass (left) 0.2 1.0 4.1 0.2 -0.4 0.3 -0.9 2.0