TWAS hub - DDX5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1168	0.0495	5.9e-03	0.128	NA	0.116	NA	0.119	3.0e-10	NA	2.3e-09	NA	1.5e-09
2	NTR	Blood	0.0978	0.0264	9.9e-07	0.041	0.028	0.029	0.040	0.040	2.9e-13	1.4e-09	8.2e-10	6.4e-13	5.2e-13
3	YFS	Blood	0.4188	0.0441	0.0e+00	0.212	0.180	0.210	0.213	0.210	1.9e-67	1.0e-56	7.1e-67	7.7e-68	8.6e-67

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Wears glasses or contact lenses	16.5	19.0	20.3	-4.2	-4.3	-4.5
Had menopause	15.0	18.8	19.3	-4.3	-4.4	-4.3
Heel T-Score	13.5	107.5	110.2	10.3	10.5	10.3
Respiratory disease	13.3	29.6	30.9	5.3	5.4	5.6
Ever used hormone-replacement therapy (HRT)	10.8	13.8	14.7	-3.7	-3.6	-3.8
Asthma (self-reported)	10.6	21.1	22.8	4.4	4.6	4.8
Asthma	10.0	19.6	21.2	4.2	4.4	4.6
Systolic Blood Pressure	9.9	49.7	51.8	7.2	7.1	6.8
Hayfever/allergic rhinitis (self-reported)	9.0	11.9	12.1	3.4	3.5	3.5
Number of incorrect matches in round	8.4	14.0	14.7	3.7	3.8	3.7
Heel bone mineral density (BMD) T-score, automated (left)	6.8	15.4	16.3	3.9	4.0	3.8
Lung FEV1/FVC ratio	6.6	33.3	35.5	-6.0	-5.8	-5.5
Pain all over the body in last month	6.5	6.9	7.6	2.7	2.7	2.4
Number of operations (self-reported)	6.5	9.7	11.0	-3.0	-3.0	-3.3
Nervous feelings	6.4	11.9	12.4	3.5	3.3	3.5
High blood pressure (mother)	6.3	8.8	8.9	3.0	3.0	3.0
Heel bone mineral density (BMD) T-score, automated (right)	6.2	14.2	14.7	3.7	3.8	3.8
Wheeze or whistling in the chest in last year	5.9	10.5	10.6	3.2	3.2	3.2
Had other major operations	5.8	7.0	8.1	-2.6	-2.5	-2.8
Prospective memory result	5.8	7.2	7.4	2.7	2.7	2.6
Guilty feelings	5.8	8.8	9.3	-3.0	-2.8	-3.0
Worry (Nagel 2018)	5.5	11.6	12.1	3.5	3.4	3.3
Coronary Artery Disease (CAD)	5.1	6.1	7.3	-2.4	-2.3	-2.7
Cardiovascular Disease	5.1	17.0	17.8	4.2	4.2	3.9
Medication: Amlodipine	5.1	7.1	7.2	2.7	2.7	2.6
Myopia	5.0	7.3	7.7	-2.7	-2.8	-2.6
Birth weight of first child	4.9	9.0	9.9	-2.9	-2.9	-3.2
Average weekly beer plus cider intake	4.9	7.0	7.7	2.7	2.8	2.5
Number of self-reported non-cancer illnesses	4.8	8.3	8.8	2.9	3.0	2.8
Systolic blood pressure, automated reading	4.7	13.6	14.5	3.8	3.8	3.5
Medication for cholesterol, blood pressure or diabetes	4.7	7.7	8.5	-2.9	-2.9	-2.5
Allergy	4.6	10.6	11.0	-3.2	-3.3	-3.3
Medication: Blood pressure	4.4	7.8	8.1	2.8	2.8	2.7
Ovarian Cancer	4.1	5.4	5.8	-2.4	-2.3	-2.3
Peak expiratory flow (PEF)	4.1	9.4	9.9	-3.1	-3.1	-3.0
Medication: Ibuprofen	4.1	4.9	6.5	-2.1	-2.0	-2.5
Bipolar Disorder or Schizophrenia	4.0	9.7	11.4	3.1	2.9	3.4
Medication: Cholesterol lowering	4.0	6.2	6.6	2.6	2.5	2.4
High blood pressure	3.9	10.7	11.4	3.3	3.4	3.1
Hypertension (Self-reported)	3.9	10.8	11.5	3.3	3.4	3.1
Allergy or Eczema	3.8	10.1	10.2	3.1	3.2	3.2
Bilateral oophorectomy (both ovaries removed)	3.8	4.4	4.7	2.1	2.2	2.0
Tense / ‘highly strung’	3.8	6.3	6.8	2.5	2.5	2.6
Medication: Ventolin 100micrograms inhaler	3.8	4.8	5.1	2.1	2.2	2.2
Age started oral contraceptive pill	3.7	4.6	4.9	-2.2	-2.1	-2.2
Medication: Aspirin	3.6	4.7	5.2	-2.1	-2.1	-2.3
Bipolar Disorder (2018)	3.5	5.5	6.6	2.3	2.1	2.6
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.4	5.7	-1.9	-1.9	-2.4
Emphysema/chronic bronchitis	3.5	3.9	4.2	2.1	2.0	1.9
Hearing aid user	3.5	4.0	4.1	-2.0	-2.0	-2.0
Medication for hormone replacement therapy	3.4	3.8	4.1	-1.9	-1.9	-2.0
Breast Cancer	3.3	8.0	8.4	-2.9	-2.8	-2.8
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	5.9	2.2	2.2	2.4
Intelligence (Savage-Jansen 2018)	3.2	9.7	9.9	-3.1	-3.1	-3.1
Relative age of first facial hair	3.2	6.6	6.6	2.6	2.6	2.6
Vascular/heart problems diagnosed by doctor	3.1	8.5	9.1	-3.0	-3.0	-2.7
Lung cancer (father)	3.0	3.5	3.6	-1.9	-1.8	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.7	10.4	-3.0	-3.1	-3.2
Commuting to job workplace: Walk	3.0	3.2	3.4	-1.8	-1.9	-1.7
Overall health rating	2.9	6.2	6.5	2.5	2.5	2.4
Medication: Aspirin	2.9	3.8	4.1	-1.9	-1.9	-2.0
Knee pain experienced in last month	2.9	4.5	4.9	2.2	2.2	2.0
Sensitivity / hurt feelings	2.8	4.8	5.0	2.2	2.2	2.2
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	4.6	2.1	2.1	2.1
Medication: Lisinopril	2.8	3.6	3.9	2.0	2.0	1.7
Hayfever, allergic rhinitis or eczema	2.7	5.9	6.2	2.4	2.5	2.4
Forced expiratory volume in 1-second (FEV1)	2.7	9.1	9.9	-2.9	-3.0	-3.1
Birth weight	2.7	5.9	6.2	-2.4	-2.4	-2.5
Medication: Allopurinol	2.7	3.6	4.2	1.8	1.9	2.0
Supplements: Glucosamine	2.6	3.4	3.5	-1.9	-1.9	-1.8
Father’s age at death	2.6	3.6	3.9	-2.0	-1.9	-1.8
Arm predicted mass (right)	2.6	13.3	14.0	-3.6	-3.6	-3.7
Illnesses of father: High blood pressure	2.6	3.3	3.5	1.7	1.8	1.9
Trunk fat-free mass	2.4	13.9	14.7	-3.7	-3.7	-3.8
Illnesses of mother	2.4	2.9	3.2	-1.6	-1.7	-1.8
Trunk predicted mass	2.4	13.8	14.6	-3.7	-3.7	-3.8
Arm fat-free mass (right)	2.4	12.2	12.9	-3.5	-3.4	-3.6
Arm fat-free mass (left)	2.4	12.1	12.7	-3.5	-3.4	-3.6
Age at first live birth	2.3	4.1	4.2	-2.0	-2.0	-2.1
Whole body fat-free mass	2.3	13.3	14.1	-3.6	-3.6	-3.8
Schizophrenia (2018)	2.2	4.6	5.1	2.1	2.1	2.3
Age at First Birth	2.2	3.2	3.6	-1.8	-1.9	-1.7
Height	2.2	41.5	43.3	-6.2	-6.5	-6.6
Worrier / anxious feelings	2.2	4.2	4.9	2.2	2.1	1.8
Breastfed as a baby	2.2	2.7	2.9	-1.6	-1.6	-1.7
Leg fat-free mass (right)	2.2	11.9	12.7	-3.4	-3.4	-3.6
Friendships satisfaction	2.2	2.7	3.4	-1.4	-1.6	-1.9
Whole body water mass	2.2	12.6	13.3	-3.5	-3.5	-3.6
Leg predicted mass (right)	2.2	11.5	12.3	-3.4	-3.3	-3.5
Neuroticism (Nagel 2018)	2.1	4.9	5.2	2.3	2.3	2.1
Impedance of leg (right)	2.1	10.4	11.0	3.2	3.2	3.3
Migraine (self-reported)	2.1	2.6	2.9	-1.7	-1.7	-1.5
Eye problems/disorders: Cataract	2.1	2.4	2.5	1.5	1.5	1.6
Arm predicted mass (left)	2.1	10.9	11.5	-3.3	-3.2	-3.4
Verbal and Numeric Reasoning (VNR)	2.0	4.8	4.8	-2.2	-2.2	-2.2
Basal metabolic rate	2.0	10.9	11.5	-3.3	-3.2	-3.4
Fluid intelligence score	1.9	4.0	4.2	-2.0	-1.9	-2.0
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	2.7	1.6	1.5	1.5
Headache pain in last month	1.9	3.2	3.4	-1.7	-1.8	-1.8
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.5	1.4	1.4	1.6
Suffer from ‘nerves’	1.9	3.0	3.3	1.7	1.7	1.8
Breast cancer (self-reported)	1.9	2.3	2.3	-1.5	-1.5	-1.5
Medication: Atenolol	1.8	2.3	2.7	1.5	1.6	1.4
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	2.4	1.5	1.6	1.3
Family relationship satisfaction	1.8	2.2	2.2	1.5	1.5	1.5
Schizophrenia (2014)	1.7	3.8	4.1	1.9	1.9	2.0
Average weekly spirits intake	1.7	2.1	2.4	-1.5	-1.3	-1.5
Leg fat-free mass (left)	1.7	9.1	9.7	-3.0	-2.9	-3.1
Illnesses of siblings	1.7	2.4	2.4	-1.5	-1.6	-1.6
Miserableness	1.7	2.9	3.2	1.8	1.8	1.6
Basal cell carcinoma (self-reported)	1.7	2.0	2.2	-1.3	-1.5	-1.4
Leg predicted mass (left)	1.6	8.6	9.2	-2.9	-2.9	-3.0
Hearing difficulty/problems with background noise	1.6	2.6	2.9	1.6	1.7	1.5
Standing height	1.6	15.9	17.3	-3.8	-4.0	-4.2
High cholesterol (Self-reported)	1.6	2.8	3.1	1.7	1.8	1.5
Medication: Metformin	1.5	2.1	2.4	-1.4	-1.4	-1.5
High blood pressure (siblings)	1.5	2.2	2.8	1.4	1.4	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	2.3	1.4	1.3	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.0	1.4	1.4	1.2
LDL Cholesterol	1.4	2.3	2.8	1.5	1.7	1.4
BMI	1.4	8.1	8.8	-3.0	-2.8	-2.8
Comparative body size at age 10	1.4	4.0	4.3	-2.0	-2.1	-1.9
Neuroticism (2016)	1.3	1.9	1.9	1.4	1.4	1.3
Average weekly fortified wine intake	1.3	1.6	1.8	-1.2	-1.2	-1.3
Serious illness, injury or assault to yourself	1.3	1.6	1.8	-1.2	-1.2	-1.3
Waist circumference	1.3	4.6	5.0	-2.2	-2.1	-2.2
Weight	1.3	6.5	6.8	-2.6	-2.5	-2.6
Blood clot in the leg (DVT)	1.3	1.7	1.8	-1.4	-1.3	-1.2
Osteoporosis (self-reported)	1.3	1.6	1.8	-1.2	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.3	-1.5	-1.6	-1.8
Major Depression (MDD)	1.2	1.4	1.7	-1.3	-1.0	-1.3
Medication: Ramipril	1.2	1.6	1.8	1.3	1.3	1.1
Impedance of arm (right)	1.2	5.5	5.8	2.4	2.3	2.4
Had major operations	1.2	1.4	1.7	1.2	1.3	1.0
Medication: Bendroflumethiazide	1.2	1.8	2.0	1.4	1.4	1.2
Alzheimer’s Disease (in mother)	1.1	1.3	1.4	1.1	1.1	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	1.6	1.2	1.2	1.3
Impedance of leg (left)	1.1	5.2	5.6	2.3	2.2	2.4
Hip circumference	1.1	4.5	4.9	-2.2	-2.0	-2.2
Exposure to tobacco smoke outside home	1.1	1.4	1.5	1.2	1.2	1.1
Mean time to correctly identify matches	1.1	2.1	2.3	-1.4	-1.4	-1.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	1.8	1.1	1.1	1.3
Impedance of whole body	1.1	5.3	5.6	2.4	2.2	2.4
Lupus	1.0	1.5	1.7	1.3	1.3	1.0
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.4	1.1	1.2	0.9
Townsend deprivation index at recruitment	1.0	1.3	1.5	1.2	1.2	1.0
Gout (self-reported)	1.0	1.3	1.6	1.1	1.3	1.1
Forced vital capacity (FVC), Best measure	1.0	3.7	4.6	-1.7	-1.9	-2.1
Illnesses of father: Heart disease	1.0	1.4	1.7	-1.1	-1.1	-1.3
Smoking status: Previous	1.0	1.5	1.6	1.2	1.2	1.3
Average weekly red wine intake	1.0	1.5	1.7	-1.2	-1.1	-1.3
Osteoarthritis (self-reported)	1.0	1.3	1.3	1.1	1.1	1.1
Depressed Affect (Nagel 2018)	0.9	1.9	2.2	1.5	1.4	1.2
Tanning	0.9	10.6	10.8	3.2	3.3	3.3
Maternal smoking around birth	0.9	1.3	1.5	-1.2	-1.2	-1.0
Forced vital capacity (FVC)	0.9	3.4	4.3	-1.6	-1.8	-2.1
Medication for pain relief, constipation, heartburn	0.9	1.5	2.5	1.0	1.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.4	1.1	1.2	0.8
Diastolic blood pressure, automated reading	0.9	2.7	3.4	1.8	1.7	1.3
Commuting to job workplace: Cycle	0.9	1.1	1.3	-1.1	-1.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	1.3	-1.1	-1.1	-1.0
Schizophrenia vs Biploar Disorder	0.8	1.1	3.3	0.0	0.0	1.8
Hand grip strength (right)	0.8	2.3	2.6	-1.5	-1.6	-1.4
Financial difficulties in last 2 years	0.8	1.1	1.1	-1.0	-1.0	-1.0
Number of live births	0.8	1.2	1.3	1.0	1.1	1.1
Happiness	0.8	1.0	1.2	-0.9	-1.1	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.0	-1.0	-0.9	-1.0
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.2	0.9	1.0	1.1
Loneliness, isolation	0.8	1.0	1.2	-1.0	-0.9	-1.1
Average weekly champagne plus white wine intake	0.8	1.1	1.2	-1.1	-1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.2	-0.8	-0.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	0.8	-0.9	-0.8	-0.8
Supplements: Zinc	0.7	0.8	1.0	-0.8	-1.0	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.0	-0.8	-0.8	-1.0
Qualifications: CSEs or equivalent	0.7	0.9	1.2	0.9	0.9	1.1
Neuroticism score	0.7	1.5	1.6	1.3	1.3	1.1
Mouth/teeth dental problems: Dentures	0.7	1.3	1.4	-1.1	-1.1	-1.2
Impedance of arm (left)	0.7	3.1	3.5	1.9	1.7	1.8
Worry too long after embarrassment	0.7	1.1	1.2	-1.0	-1.0	-1.1
Medication: Seretide 50 evohaler	0.7	0.8	0.9	0.8	0.9	0.9
Diabetes diagnosed by doctor	0.7	1.2	1.4	-1.1	-0.9	-1.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.0	-1.0	-0.9	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.0	-0.8	-0.9	-1.0
Fasting Glucose	0.6	0.7	0.8	0.8	0.9	0.9
Medication: Co-codamol	0.6	0.7	1.1	0.9	1.0	0.5
Current tobacco smoking	0.6	1.0	1.2	-0.9	-1.0	-1.1
Hair/balding pattern: Pattern 2	0.6	0.7	1.0	0.7	0.8	1.0
Qualifications: None of the above	0.6	1.3	1.7	1.0	1.0	1.3
Falls in the last year	0.6	0.8	0.9	-1.0	-0.9	-0.7
Medication for cholesterol	0.6	0.8	1.1	0.9	0.8	1.0
Arm fat mass (left)	0.6	2.4	2.7	-1.6	-1.5	-1.5
Mother’s age at death	0.6	0.7	0.8	-0.9	-0.9	-0.7
Commuting to job workplace: Public transport	0.6	0.7	0.8	-0.8	-0.8	-0.9
Vitamin and mineral supplements	0.5	0.6	0.8	0.8	0.9	0.7
Diabetes (self-reported)	0.5	0.8	0.9	-0.9	-0.8	-0.9
Depression (self-reported)	0.5	0.6	0.7	0.8	0.8	0.8
Arm fat mass (right)	0.5	2.0	2.2	-1.5	-1.4	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	0.9	0.9	1.0	0.9
Glaucoma (self-reported)	0.5	0.6	0.6	0.8	0.8	0.7
Mineral and other dietary supplements	0.5	0.7	0.8	0.9	0.9	0.7
Ever taken oral contraceptive pill	0.5	0.6	0.7	-0.7	-0.8	-0.7
Medication: Blood pressure	0.5	0.9	1.1	1.0	1.0	0.8
Supplements: Calcium	0.5	0.6	0.8	-0.8	-0.9	-0.6
Pack years of smoking	0.5	0.7	0.8	-0.8	-0.8	-0.9
Depression (Nagel 2018)	0.4	0.6	0.6	0.7	0.7	0.8
Lung FVC	0.4	2.0	3.2	-1.1	-1.3	-1.8
Neuroticism	0.4	1.1	1.2	1.1	1.1	0.9
Hand grip strength (left)	0.4	1.0	1.2	-1.0	-1.1	-0.9
Diabetes (father)	0.4	0.5	0.6	0.7	0.7	0.7
Chronic bronchitis/emphysema (father)	0.4	0.4	0.5	0.6	0.6	0.7
Trunk fat mass	0.4	1.9	2.1	-1.5	-1.3	-1.4
Exposure to tobacco smoke at home	0.4	0.5	0.6	0.8	0.7	0.6
Pulse wave reflection index	0.4	0.5	0.9	0.5	0.6	0.9
Loud music exposure frequency	0.4	0.5	0.6	-0.8	-0.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.7	-0.8	-0.7
Whole body fat mass	0.4	1.6	1.9	-1.4	-1.2	-1.3
Comparative height size at age 10	0.4	2.5	2.9	-1.4	-1.6	-1.7
Leg pain on walking	0.4	0.5	0.6	0.8	0.8	0.6
Supplements: Vitamin C	0.4	0.5	0.8	0.7	0.6	0.9
Smoking status: Current	0.4	0.6	0.7	-0.7	-0.8	-0.8
Ever smoked	0.4	0.7	0.7	0.8	0.8	0.9
Leg fat mass (left)	0.4	1.6	1.9	-1.4	-1.2	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.5	0.6	0.6	0.7
Blood Eosinophil Count	0.3	2.0	2.0	1.4	1.4	1.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	0.7	0.5	0.5
Pack years adult smoking proportion	0.3	0.4	0.4	-0.6	-0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.4	0.7	0.6	0.6
Mouth/teeth dental problems	0.3	0.5	0.6	-0.8	-0.7	-0.6
Medication: Simvastatin	0.3	0.5	0.6	0.7	0.7	0.6
Number of full brothers	0.3	0.4	0.6	0.6	0.3	0.8
Number of children fathered	0.3	0.4	0.6	0.6	0.7	0.4
Qualifications: College or University degree	0.3	0.9	1.0	1.0	0.9	1.0
Alcohol intake frequency.	0.3	0.7	0.8	0.9	0.8	0.8
Chest pain or discomfort	0.3	0.5	0.6	0.8	0.7	0.6
Age at last live birth	0.3	0.4	0.5	-0.6	-0.7	-0.6
Long-standing illness, disability or infirmity	0.3	0.5	0.6	0.8	0.8	0.5
Fractured/broken bones in last 5 years	0.3	0.4	0.5	-0.7	-0.6	-0.5
Cholesterol lowering medication	0.3	0.5	0.6	-0.7	-0.6	-0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.4	-0.4	-0.6
HDL Cholesterol	0.2	0.3	0.4	-0.6	-0.6	-0.5
Blood White Count	0.2	1.2	1.2	-1.1	-1.1	-1.1
Angina	0.2	0.2	0.3	0.6	0.5	0.2
Diabetes (mother)	0.2	0.3	0.4	-0.5	-0.5	-0.6
Relative age voice broke	0.2	0.4	0.5	0.6	0.5	0.7
Multivitamins +/- minerals	0.2	0.2	0.2	-0.5	-0.5	-0.4
Body mass index (BMI)	0.2	0.8	1.1	-1.0	-0.8	-0.9
Past tobacco smoking	0.2	0.4	0.4	-0.6	-0.6	-0.6
Alcohol intake versus 10 years previously	0.2	0.3	0.3	0.5	0.6	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	-0.5	-0.5	-0.7
Medication: Lansoprazole	0.2	0.2	0.3	0.5	0.6	0.3
Health satisfaction	0.2	0.3	0.4	0.6	0.6	0.3
Shortness of breath walking on level ground	0.2	0.3	0.4	0.6	0.6	0.4
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.4	-0.5	-0.3
Angina (self-reported)	0.2	0.3	0.4	0.6	0.6	0.3
Medication: Omeprazole	0.2	0.2	0.4	-0.4	-0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.2	0.5	0.5	0.5
Leg fat mass (right)	0.2	0.8	1.0	-1.0	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.4	-0.4	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.5	0.5	0.5
Medication: Gliclazide	0.2	0.3	0.4	0.5	0.6	0.4
Medication: Atorvastatin	0.2	0.3	0.4	0.5	0.6	0.5
Heart disease (siblings)	0.2	0.2	0.3	-0.3	-0.4	-0.6
Crohns Disease (2017)	0.1	0.1	0.2	0.3	0.4	0.4
Prostate Cancer	0.1	0.2	0.3	-0.5	-0.5	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.3	0.3	0.4
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.3	0.2	0.4
Ulcerative Colitis	0.1	0.1	0.1	0.3	0.3	0.2
Blood Platelet Count	0.1	0.8	1.0	1.0	0.9	0.7
Waist Hip Ratio (WHR)	0.1	0.3	0.4	-0.6	-0.6	-0.6
Hypothyroidism (self reported)	0.1	0.1	0.2	0.4	0.2	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.4	-0.2	-0.4
Chronotype (morning person)	0.1	0.3	0.4	-0.6	-0.6	-0.4
Number of treatments/medications taken	0.1	0.2	0.2	0.4	0.5	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	0.3	0.2	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.2	-0.2	-0.5
Trunk fat percentage	0.1	0.3	0.4	-0.6	-0.4	-0.5
Fed-up feelings	0.1	0.2	0.3	0.5	0.6	0.3
Taking other prescription medications	0.1	0.2	0.3	0.5	0.6	0.3
Age when periods started (menarche)	0.1	0.2	0.3	-0.4	-0.4	-0.6
Alcohol usually taken with meals	0.1	0.2	0.2	0.4	0.4	0.4
Time employed in main current job	0.1	0.1	0.2	-0.3	-0.4	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.4	-0.3	-0.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.3	-0.3	-0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	-0.5	-0.6	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.2	0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.4	-0.4	-0.6
Medication: Paracetamol	0.1	0.2	0.3	-0.4	-0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.3	-0.4	-0.3
Leg fat percentage (right)	0.1	0.3	0.4	0.4	0.6	0.6
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.1	0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.1	0.4	0.4	0.2
Arm fat percentage (left)	0.1	0.4	0.5	-0.7	-0.5	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.2	-0.3	-0.4	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.4	-0.4	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.2	0.4	0.4	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.3	0.3	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.2	-0.5	-0.4	-0.3
Medication: Paracetamol	0.1	0.2	0.2	-0.4	-0.3	-0.5
Irritability	0.1	0.2	0.3	0.5	0.4	0.5
Risk taking	0.1	0.1	0.2	-0.4	-0.5	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	-0.4	-0.4	-0.5
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.1	0.2	0.1
Ulcerative Colitis (UC)	0.0	0.0	0.0	-0.0	0.1	-0.0
Reaction Time	0.0	0.0	0.0	0.0	0.1	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.1
Crohns Disease (2012)	0.0	0.0	0.1	0.0	0.0	-0.2
Mean Putamen Volume	0.0	0.0	0.1	0.3	0.2	0.2
HbA1C	0.0	0.0	0.0	0.1	0.2	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	0.0	0.1	-0.1
Triglycerides	0.0	0.0	0.0	0.2	0.2	-0.0
Blood Red Count	0.0	0.1	0.2	-0.2	-0.2	0.4
Smoking Status	0.0	0.1	0.1	0.3	0.3	0.3
Hair Pigment	0.0	0.0	0.1	0.2	0.2	0.3
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.2	0.1	0.2
Severe depression (siblings)	0.0	0.0	0.1	0.1	-0.0	0.3
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.1	-0.1	-0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.1	-0.2	-0.1
Sitting height	0.0	0.2	0.2	-0.4	-0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.0	-0.0	0.1
Heart attack	0.0	0.1	0.1	-0.2	-0.2	-0.3
Arm fat percentage (right)	0.0	0.1	0.2	-0.4	-0.2	-0.2
Pulse rate	0.0	0.0	0.0	0.1	0.1	-0.1
Noisy workplace	0.0	0.0	0.1	-0.2	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	-0.2	-0.2
Length of working week for main job	0.0	0.0	0.0	0.1	0.1	0.1
Body fat percentage	0.0	0.1	0.2	-0.5	-0.2	-0.3
Pulse wave peak to peak time	0.0	0.0	0.0	0.0	0.0	-0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.1	-0.0	-0.2
Heart disease (mother)	0.0	0.0	0.0	-0.1	0.1	-0.2
Pulse rate, automated reading	0.0	0.1	0.3	-0.2	-0.4	-0.5
Number of full sisters	0.0	0.0	0.0	-0.2	-0.1	-0.1
Mood swings	0.0	0.1	0.1	0.3	0.3	0.2
Ever had bowel cancer screening	0.0	0.0	0.0	-0.1	-0.1	-0.2
Back pain experienced in last month	0.0	0.0	0.0	0.1	0.1	0.0
Financial situation satisfaction	0.0	0.0	0.1	0.2	0.2	0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	0.3	0.0
Alcohol drinker status: Never	0.0	0.0	0.1	0.0	-0.2	-0.0
Leg fat percentage (left)	0.0	0.0	0.0	-0.1	0.1	0.1
Ever depressed for a whole week	0.0	0.0	0.1	0.2	0.3	0.1
Unable to work because of sickness or disability	0.0	0.0	0.0	0.1	0.0	0.0
Pain experienced in last month	0.0	0.0	0.1	-0.0	-0.1	0.3
Alcohol drinker status: Previous	0.0	0.0	0.0	0.1	0.1	-0.0

Hub : Genes

DDX5

Models

Trait associations