Hub : Genes

MRPS6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.099 0.0402 0.0059 0.038 NA 0.005 NA 0.000 6.0e-04 NA 1.2e-01 NA 3.4e-01
2 YFS Blood 0.128 0.0255 0.0000 0.082 0.097 0.121 0.117 0.117 1.8e-25 6.6e-30 1.5e-37 3.9e-36 2.6e-36

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.4 0.7 1.3 -1.1 0.2
Bipolar Disorder or Schizophrenia 0.6 1.5 3.1 -0.1 -1.7
Depressed Affect (Nagel 2018) 0.1 0.3 0.3 0.6 0.5
Depression (Nagel 2018) 0.5 0.8 1.0 1.0 0.8
Intelligence (Savage-Jansen 2018) 1.1 3.5 4.9 1.4 -2.2
Neuroticism (Nagel 2018) 0.9 2.0 4.1 0.1 2.0
Schizophrenia (2018) 1.6 3.3 6.0 0.8 -2.4
Schizophrenia vs Biploar Disorder 1.6 2.1 3.5 0.8 -1.9
Worry (Nagel 2018) 0.8 1.7 3.4 0.1 1.9
Alzheimer’s Disease (in mother) 2.0 2.3 3.4 -1.1 1.8
Alzheimer’s Disease (in father) 0.5 0.6 0.6 0.8 -0.7
Alzheimer’s Disease (including proxy) 0.4 0.5 0.8 -0.6 0.9
Crohns Disease (2017) 0.0 0.1 0.1 0.3 -0.4
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 -0.6 -0.1
Ulcerative Colitis (UC) 0.2 0.4 0.5 -0.7 0.5
Major Depression (MDD) 2.5 3.1 4.6 1.2 -2.2
Reaction Time 0.1 0.1 0.2 -0.2 -0.4
Verbal and Numeric Reasoning (VNR) 0.7 1.6 3.2 0.1 -1.8
Breast Cancer 0.2 0.4 0.7 0.4 0.8
Ovarian Cancer 0.6 0.8 1.5 -1.2 -0.1
Prostate Cancer 0.4 0.6 1.2 -0.1 -1.1
Age at First Birth 1.4 2.0 2.3 -1.5 1.3
Bipolar Disorder (2011) 0.1 0.1 0.2 0.4 -0.3
Body Mass Index (BMI) (2010) 1.3 1.7 2.1 1.5 1.2
Coronary Artery Disease (CAD) 6.4 7.6 8.3 2.6 -2.9
Crohns Disease (2012) 0.2 0.3 0.5 -0.7 -0.2
Mean Putamen Volume 0.0 0.0 0.0 -0.0 -0.1
Fasting Glucose 0.4 0.4 0.5 0.6 -0.7
HbA1C 0.2 0.2 0.3 0.5 0.5
HDL Cholesterol 1.8 3.0 5.9 -0.4 -2.4
LDL Cholesterol 0.4 0.6 1.1 -0.4 1.1
Lupus 2.0 3.0 6.0 -0.2 -2.4
Neuroticism (2016) 0.3 0.5 1.0 -0.1 -1.0
Primary Biliary Cirrhosis 0.0 0.0 0.1 0.3 -0.0
Rheumatoid Arthritis 0.1 0.1 0.2 -0.4 0.1
Schizophrenia (2014) 1.4 3.0 6.0 -0.1 -2.5
Triglycerides 0.2 0.3 0.4 0.7 -0.4
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.2 0.7 1.5
Ulcerative Colitis 0.0 0.1 0.1 -0.3 -0.2
Blood Eosinophil Count 0.1 1.0 1.9 0.2 -1.4
Blood Platelet Count 0.7 8.7 11.0 3.3 -2.5
Blood Red Count 0.5 4.4 8.6 2.9 0.5
Blood White Count 1.1 8.3 9.8 3.1 -2.6
Heel T-Score 1.6 13.0 15.4 3.9 3.3
BMI 0.3 1.5 2.0 1.4 -1.0
Height 4.4 85.0 168.7 -13.0 1.1
Waist Hip Ratio (WHR) 1.5 6.7 8.4 -2.3 -2.9
Systolic Blood Pressure 0.3 1.7 2.0 -1.2 -1.4
Smoking Status 4.7 11.2 19.3 4.4 -1.8
Allergy or Eczema 0.5 1.3 2.3 -0.5 1.5
Cardiovascular Disease 0.2 0.7 0.8 -0.7 -0.9
Hypothyroidism (self reported) 0.3 0.6 1.0 -1.0 0.6
Respiratory disease 0.7 1.6 2.0 1.4 1.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 1.0 -1.0 1.0
Lung FEV1/FVC ratio 10.3 52.1 90.8 -9.5 3.7
Lung FVC 3.1 16.0 30.9 5.6 1.0
Neuroticism 0.3 0.6 1.2 0.1 1.1
Chronotype (morning person) 0.7 1.5 2.5 1.6 0.7
Hair Pigment 0.1 3.0 5.4 0.8 -2.3
Tanning 0.1 0.8 1.4 1.2 0.4
Hand grip strength (left) 0.5 1.2 2.4 -1.6 0.2
Number of treatments/medications taken 0.3 0.6 0.6 0.8 -0.7
Average weekly spirits intake 1.7 2.1 3.1 1.1 -1.8
Sensitivity / hurt feelings 1.1 1.9 3.7 -0.4 1.9
Frequency of depressed mood in last 2 weeks 1.1 1.6 2.7 1.6 0.7
Hearing difficulty/problems: Yes 0.2 0.3 0.6 0.8 -0.2
Relative age of first facial hair 1.2 2.5 4.7 -2.2 0.6
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.4 1.8 -0.5
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.5 0.1
Ever had hysterectomy (womb removed) 1.3 1.5 2.9 -0.2 1.7
Systolic blood pressure, automated reading 0.2 0.6 0.9 -0.5 -1.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 0.7 0.7 0.8
Angina 6.3 8.3 12.2 3.5 -2.1
Medication for hormone replacement therapy 0.2 0.2 0.3 -0.5 0.4
Vitamin and mineral supplements 2.6 3.6 4.3 -2.1 1.7
Supplements: Zinc 2.0 2.1 2.7 1.2 -1.7
Medication: Co-codamol 4.5 5.2 10.1 3.2 0.6
Medication: Metformin 0.1 0.1 0.2 -0.2 0.5
Diabetes (father) 3.2 4.0 7.4 -0.8 2.7
Diabetes (mother) 0.2 0.2 0.5 0.7 0.2
Severe depression (siblings) 0.8 0.9 1.1 0.9 1.0
Pack years adult smoking proportion 0.4 0.6 0.7 -0.7 -0.8
Impedance of leg (right) 0.6 3.1 3.4 -1.7 1.8
Leg fat-free mass (left) 0.6 3.0 4.1 -2.0 -1.4
Trunk fat percentage 0.7 2.6 5.3 0.0 -2.3
Hand grip strength (right) 1.1 2.9 5.5 -2.3 0.6
Townsend deprivation index at recruitment 5.5 7.7 12.0 3.5 -1.8
Current tobacco smoking 3.3 5.5 8.8 3.0 -1.5
Average weekly fortified wine intake 3.1 3.7 5.0 -2.2 1.5
Maternal smoking around birth 1.9 2.7 4.7 0.9 -2.2
Fed-up feelings 2.3 4.3 6.7 2.6 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.8 4.9 2.2 0.8
Relative age voice broke 0.7 1.1 1.5 -1.2 -0.9
Taking other prescription medications 0.1 0.1 0.2 -0.4 0.4
Age when periods started (menarche) 0.9 2.2 4.4 -0.2 2.1
Bilateral oophorectomy (both ovaries removed) 2.1 2.5 2.7 -1.6 1.5
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.5 7.9 2.8 2.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.3 1.1 -0.2
Qualifications: CSEs or equivalent 2.0 2.6 2.6 1.6 -1.6
Serious illness, injury or assault to yourself 0.1 0.1 0.3 0.1 -0.5
High blood pressure 0.2 0.6 0.9 -1.0 -0.5
Hayfever, allergic rhinitis or eczema 0.4 1.0 1.7 -0.4 1.3
Multivitamins +/- minerals 4.1 5.2 10.3 3.2 -0.4
Stomach or abdominal pain in last month 0.2 0.2 0.2 0.4 0.5
Supplements: Glucosamine 0.1 0.1 0.2 0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.2 1.5 0.6
Medication: Atenolol 0.8 1.1 1.4 0.9 1.2
Medication: Levothyroxine sodium 0.1 0.1 0.1 -0.3 -0.3
Sitting height 0.8 5.6 10.0 -3.2 -1.1
Chronic bronchitis/emphysema (father) 2.0 2.4 4.8 2.2 -0.0
High blood pressure (mother) 0.0 0.1 0.1 0.4 -0.0
Body mass index (BMI) 0.9 4.0 6.1 2.5 -1.3
Impedance of leg (left) 0.8 4.0 4.9 -2.2 1.8
Leg predicted mass (left) 0.6 3.2 4.4 -2.1 -1.4
Trunk fat mass 0.5 2.3 4.0 -0.8 -2.0
Waist circumference 0.7 2.4 4.7 0.2 -2.2
Number of incorrect matches in round 0.3 0.5 1.0 -0.2 1.0
Past tobacco smoking 3.1 5.6 7.2 -2.7 2.0
Alcohol usually taken with meals 4.4 7.1 7.6 -2.8 2.6
Nervous feelings 0.4 0.7 1.3 0.4 1.1
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.2 7.3 2.7 1.1
Hearing difficulty/problems with background noise 0.1 0.2 0.3 0.1 0.6
Hair/balding pattern: Pattern 2 0.3 0.4 0.6 0.5 -0.8
Had menopause 1.9 2.3 3.6 -1.9 -1.0
Had other major operations 0.0 0.0 0.0 0.0 0.2
Forced vital capacity (FVC) 0.4 1.6 3.1 -0.4 1.8
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.2 4.6 2.2 1.9
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.8 0.7 -0.9
Qualifications: None of the above 1.0 2.2 4.3 2.1 0.3
Financial difficulties in last 2 years 2.3 3.0 5.1 2.3 -1.0
Mouth/teeth dental problems 2.6 4.0 7.7 -2.8 0.6
Heart attack 5.4 6.9 7.4 2.5 -2.7
Allergy 0.5 1.1 1.5 -1.2 -0.8
Pain all over the body in last month 1.8 2.0 3.1 1.8 0.9
Diabetes (self-reported) 0.8 1.2 2.3 -0.2 1.5
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.1 -1.1 1.0
Medication: Ramipril 1.1 1.4 2.8 0.2 -1.7
Medication: Simvastatin 0.3 0.4 0.4 0.6 -0.6
Fluid intelligence score 0.3 0.6 1.2 -0.2 -1.1
Illnesses of siblings 2.6 3.7 6.3 -2.5 1.0
Neuroticism score 0.9 2.0 3.1 0.9 1.7
Weight 0.5 2.2 2.7 -1.6 -1.3
Impedance of arm (right) 1.5 7.1 11.0 -3.3 -1.8
Arm fat percentage (right) 1.4 5.3 7.1 1.9 -2.7
Trunk fat-free mass 1.0 5.5 10.9 -3.3 -0.2
Hip circumference 0.3 1.5 2.0 0.9 -1.4
Time employed in main current job 0.4 0.4 0.7 -0.3 0.9
Alcohol intake versus 10 years previously 0.3 0.4 0.6 0.5 -0.8
Father’s age at death 5.7 7.7 9.6 -3.1 2.4
Worrier / anxious feelings 0.9 1.8 3.0 -0.7 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.0 1.4 0.0
Falls in the last year 0.3 0.4 0.6 0.4 -0.8
Hair/balding pattern: Pattern 3 0.1 0.2 0.4 0.6 0.2
Number of live births 1.6 2.3 2.9 -1.7 1.3
Forced expiratory volume in 1-second (FEV1) 2.7 9.0 9.7 -3.1 2.9
Pulse rate 1.0 1.6 2.8 -1.7 0.7
Happiness 0.3 0.4 0.8 -0.0 0.9
Noisy workplace 1.8 2.3 3.7 1.9 -0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.3 1.7 -1.3 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 0.0 0.2
Mouth/teeth dental problems: Dentures 0.5 0.8 1.3 1.1 0.7
Asthma 0.6 1.2 1.8 1.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.3 -0.5 0.4
Medication: Cholesterol lowering 1.3 2.0 2.9 1.0 -1.7
Depression (self-reported) 0.6 0.7 0.9 0.9 0.7
Medication: Lansoprazole 0.1 0.1 0.1 0.2 -0.3
Prospective memory result 0.3 0.4 0.6 -0.4 0.7
Lung cancer (father) 0.1 0.2 0.3 0.2 0.6
Illnesses of mother 1.4 1.7 1.8 -1.3 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 7.8 11.7 -3.4 2.0
Pulse wave Arterial Stiffness index 0.9 1.1 1.7 0.7 -1.3
Impedance of arm (left) 1.5 6.7 12.2 -3.5 -1.1
Arm fat mass (right) 0.5 2.3 4.4 0.2 -2.1
Trunk predicted mass 1.0 5.7 11.4 -3.4 -0.2
Standing height 4.2 41.4 82.8 -9.1 -0.0
Length of working week for main job 0.1 0.1 0.2 0.4 -0.3
Exposure to tobacco smoke at home 1.2 1.3 1.5 1.2 -1.1
Breastfed as a baby 0.5 0.6 1.0 -1.0 -0.5
Tense / ‘highly strung’ 0.8 1.3 2.4 0.5 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.0 0.2
Hair/balding pattern: Pattern 4 0.8 2.0 3.6 -0.6 1.9
Birth weight of first child 0.4 0.8 1.4 -0.5 1.2
Peak expiratory flow (PEF) 3.5 8.0 12.3 -3.5 1.9
Pulse wave reflection index 3.0 3.7 5.9 2.4 -1.2
Ever highly irritable/argumentative for 2 days 0.4 0.4 0.8 -0.1 -0.9
Loud music exposure frequency 1.8 2.0 2.0 1.4 1.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.5 -0.7 0.1
Mouth/teeth dental problems: Bleeding gums 2.0 2.5 3.6 1.9 -1.2
Blood clot in the leg (DVT) 0.5 0.7 1.3 1.1 0.4
Medication: Paracetamol 1.4 2.3 4.7 -0.0 2.2
Headache pain in last month 1.2 2.0 3.2 -0.9 1.8
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 4.2 -2.1 1.3
Glaucoma (self-reported) 0.6 0.7 1.3 -0.1 1.2
Gout (self-reported) 0.5 0.8 1.3 0.5 -1.1
Hypothyroidism/myxoedema (self-reported) 0.0 0.0 0.1 -0.1 0.3
Medication: Amlodipine 1.3 1.8 2.8 1.7 -0.9
Medication: Ventolin 100micrograms inhaler 0.0 0.1 0.1 -0.3 -0.2
Birth weight 0.2 0.5 1.0 0.1 1.0
Chronic bronchitis/emphysema (mother) 1.5 1.8 2.8 0.8 -1.7
High blood pressure (siblings) 2.2 3.2 6.2 2.5 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.5 0.7 -0.6 0.8
Body fat percentage 0.6 2.2 3.8 0.7 -2.0
Leg fat percentage (right) 0.7 2.7 3.6 1.9 -1.3
Arm fat-free mass (right) 0.4 2.2 4.2 -2.1 0.3
Exposure to tobacco smoke outside home 6.5 8.6 10.2 3.2 -2.7
Comparative body size at age 10 0.1 0.2 0.4 -0.2 0.6
Number of full brothers 0.1 0.2 0.3 0.6 0.0
Worry too long after embarrassment 0.6 0.9 1.5 -0.6 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 1.6 1.3 -0.9
Wheeze or whistling in the chest in last year 4.1 7.3 13.2 3.6 -1.2
Number of children fathered 1.2 1.4 1.7 -1.0 1.3
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.9 3.4 1.5 -1.9
Age at first live birth 0.1 0.2 0.2 -0.4 0.4
Pulse wave peak to peak time 1.6 1.8 2.4 -1.5 1.1
Health satisfaction 0.2 0.2 0.4 -0.6 0.3
Shortness of breath walking on level ground 3.1 3.6 5.1 2.3 -1.5
Qualifications: College or University degree 1.3 4.1 5.3 -1.7 -2.3
Eye problems/disorders: None of the above 1.1 1.3 1.9 1.4 -0.8
Mouth/teeth dental problems: Loose teeth 2.6 3.1 5.0 1.1 -2.2
Emphysema/chronic bronchitis 1.1 1.2 1.7 0.9 -1.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.3 -0.1 -0.6
Neck or shoulder pain in last month 0.0 0.0 0.0 0.2 -0.1
Medication: Blood pressure 1.0 1.7 2.4 1.6 -1.0
Angina (self-reported) 6.1 8.0 12.1 3.5 -2.0
Migraine (self-reported) 4.0 4.9 5.5 -2.1 2.4
Medication: Ibuprofen 0.3 0.4 0.4 -0.6 0.7
Medication: Allopurinol 0.2 0.3 0.4 0.7 -0.3
Medication: Omeprazole 0.3 0.4 0.8 -0.0 -0.9
Medication: Seretide 50 evohaler 0.3 0.4 0.6 0.4 -0.8
Mean time to correctly identify matches 0.0 0.0 0.1 -0.2 0.2
Heart disease (mother) 6.5 8.0 13.1 1.7 -3.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 4.4 2.1 0.5
Whole body fat mass 0.4 1.5 2.9 -0.4 -1.7
Leg fat mass (right) 0.2 0.9 1.5 0.6 -1.2
Arm predicted mass (right) 0.5 2.8 5.6 -2.4 0.2
Pulse rate, automated reading 1.5 4.7 5.4 -2.3 2.0
Alcohol intake frequency. 0.1 0.2 0.3 0.2 -0.6
Comparative height size at age 10 3.2 17.8 35.3 -5.9 0.4
Number of full sisters 1.3 1.6 3.2 0.3 -1.8
Suffer from ‘nerves’ 2.1 3.2 4.8 1.3 2.2
Overall health rating 1.7 3.7 7.0 2.6 -0.6
Chest pain or discomfort 1.3 1.9 2.6 1.6 1.1
Had major operations 0.2 0.3 0.5 0.1 -0.7
Age at last live birth 0.9 1.3 2.5 -1.6 0.4
Family relationship satisfaction 0.1 0.1 0.2 0.2 -0.4
Leg pain on walking 0.5 0.6 1.1 1.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.5 1.6 -0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.8 -1.7 -0.1
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.6 -1.2 0.8
Medication: Aspirin 0.0 0.0 0.0 0.1 0.0
Supplements: Vitamin C 2.0 2.3 4.0 2.0 -0.8
Knee pain experienced in last month 3.3 5.2 5.9 2.4 -2.1
Hypertension (Self-reported) 0.2 0.6 1.0 -1.0 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.6 -0.8 -0.6
Illnesses of father: Heart disease 5.2 7.2 9.0 2.3 -3.0
Illnesses of siblings: Diabetes 0.0 0.1 0.1 0.3 0.2
Smoking status: Previous 1.9 2.8 3.4 1.5 -1.9
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 1.3 -1.0 -1.1
Whole body fat-free mass 0.7 4.2 7.9 -2.8 -0.7
Leg fat-free mass (right) 0.7 3.6 5.0 -2.2 -1.4
Arm fat percentage (left) 1.0 4.1 5.8 1.6 -2.4
Average weekly red wine intake 0.2 0.3 0.3 0.6 -0.5
Handedness (chirality/laterality): Left-handed 2.4 2.9 3.5 1.5 -1.9
Mood swings 0.6 1.0 1.4 1.2 0.8
Loneliness, isolation 0.9 1.3 2.4 1.6 -0.3
Long-standing illness, disability or infirmity 2.1 3.2 5.3 2.3 -1.1
Ever had bowel cancer screening 1.3 1.5 2.2 0.9 1.5
Diabetes diagnosed by doctor 0.9 1.4 1.6 -1.1 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.9 1.4 0.1
Friendships satisfaction 0.8 1.0 1.9 -1.4 0.0
Qualifications: nursing, teaching 1.2 1.8 2.3 -1.5 -1.1
Commuting to job workplace: Walk 1.0 1.1 1.5 -0.8 -1.2
Eye problems/disorders: Cataract 0.3 0.4 0.7 -0.8 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.0 1.7 3.3 1.8 -0.0
Medication for cholesterol 0.4 0.6 0.6 0.8 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.1 -0.0
Back pain experienced in last month 0.7 1.0 1.7 0.4 -1.3
Mineral and other dietary supplements 1.5 2.1 3.3 -1.8 0.9
Breast cancer (self-reported) 0.4 0.4 0.9 0.1 -0.9
Asthma (self-reported) 0.5 1.1 1.3 1.1 0.9
Osteoporosis (self-reported) 1.2 1.5 2.9 -0.5 -1.7
Osteoarthritis (self-reported) 0.6 0.7 1.4 0.3 1.2
Medication: Aspirin 0.1 0.1 0.1 0.3 0.3
Medication: Gliclazide 0.3 0.4 0.7 0.3 0.8
Illnesses of father: None of the above (group 1) 2.2 2.7 3.9 -2.0 1.2
Smoking status: Current 4.0 6.4 11.8 3.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.0 4.2 6.8 -1.2 2.6
Whole body water mass 0.7 3.8 7.3 -2.7 -0.6
Leg predicted mass (right) 0.7 3.8 5.1 -2.3 -1.6
Arm fat mass (left) 0.4 1.8 3.5 0.2 -1.9
Number of self-reported non-cancer illnesses 0.8 1.3 2.2 0.7 -1.5
Average weekly champagne plus white wine intake 0.2 0.3 0.5 -0.7 0.4
Miserableness 0.7 1.2 2.5 -0.1 1.6
Guilty feelings 0.8 1.2 2.3 -0.3 1.5
Wears glasses or contact lenses 0.3 0.4 0.5 -0.5 0.7
Ever taken oral contraceptive pill 1.7 1.9 2.3 -1.2 -1.5
Hearing aid user 0.1 0.2 0.3 0.5 0.2
Mother’s age at death 4.6 5.7 11.1 -0.6 3.3
Financial situation satisfaction 0.8 1.0 1.6 1.2 -0.6
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.1 0.1 -0.3
Commuting to job workplace: Public transport 0.5 0.6 1.1 0.4 1.1
Eye problems/disorders: Glaucoma 1.1 1.3 2.2 -0.6 1.5
Medication: Blood pressure 0.6 1.1 1.7 -0.6 -1.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.7 0.8 -0.5
Supplements: Fish oil (including cod liver oil) 0.8 1.1 2.1 1.5 -0.2
High cholesterol (Self-reported) 1.6 2.9 4.5 1.1 -2.1
Medication: Bendroflumethiazide 0.1 0.1 0.2 0.5 0.2
Medication: Paracetamol 1.2 1.8 2.5 1.1 1.6
Medication: Lisinopril 0.2 0.2 0.4 0.7 -0.1
Medication: Atorvastatin 1.7 2.2 4.1 0.4 -2.0
Illnesses of father: High blood pressure 0.8 1.0 2.0 -1.4 0.3
Alcohol drinker status: Never 1.0 1.2 1.9 -1.4 -0.7
Ever smoked 3.2 5.5 7.3 2.7 -1.9
Basal metabolic rate 0.6 3.4 5.9 -2.4 -0.9
Leg fat percentage (left) 0.6 2.2 2.7 1.6 -1.3
Arm fat-free mass (left) 0.5 2.6 5.1 -2.3 -0.4
Number of operations (self-reported) 1.2 1.8 2.0 1.4 1.2
Average weekly beer plus cider intake 1.3 1.8 2.0 1.4 -1.3
Irritability 1.0 1.7 2.1 1.5 1.1
Risk taking 1.8 2.7 4.1 2.0 -1.1
Ever had prostate specific antigen (PSA) test 1.7 2.0 2.1 -1.3 1.5
Fractured/broken bones in last 5 years 0.7 0.9 1.7 -1.3 0.3
Age started oral contraceptive pill 1.8 2.3 3.6 -1.9 1.0
Diastolic blood pressure, automated reading 4.0 12.5 14.1 3.3 -3.8
Ever depressed for a whole week 0.1 0.2 0.3 0.5 -0.2
Unable to work because of sickness or disability 1.4 1.8 3.1 1.8 -0.7
Commuting to job workplace: Cycle 0.4 0.5 0.9 0.2 -0.9
Myopia 5.4 7.8 9.8 3.1 -2.4
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.9 0.2 0.9
Cholesterol lowering medication 1.1 1.6 3.1 -0.3 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 1.7 0.4 -1.3
Pain experienced in last month 0.4 0.6 0.8 -0.6 0.9
Supplements: Calcium 4.6 5.1 6.9 2.6 -1.8
Basal cell carcinoma (self-reported) 0.6 0.7 1.4 1.2 -0.2
Heart attack/myocardial infarction (self-reported) 4.6 5.9 6.3 2.5 -2.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 2.1 1.4 -0.1
Heart disease (siblings) 0.8 1.0 1.9 0.3 -1.4
Alcohol drinker status: Previous 1.5 1.8 2.4 1.0 -1.6
Pack years of smoking 0.3 0.5 0.6 -0.6 -0.8
Impedance of whole body 0.8 4.0 8.0 -2.8 0.1
Leg fat mass (left) 0.2 0.9 1.5 0.5 -1.2
Arm predicted mass (left) 0.4 2.2 4.4 -2.1 -0.1