[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr3:48,702,606-50,580,658

Best TWAS P=8.84e-10 · Best GWAS P=1.28e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	RNF123	0.23	-0.01	enet	35	0.04	3.3e-03	3.0	-5.2	2.1e-07	0.45	0.07	0.48	FALSE
2	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-4.0	-5.5	3.3e-08	0.67	0.82	0.17	FALSE
3	GTEx	Breast Mammary Tissue (Female)	RNF123	0.03	0.00	lasso	1	0.00	2.3e-01	-5.9	-5.9	3.6e-09	0.98	0.03	0.28	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	AMT	0.07	0.07	lasso	1	0.01	1.5e-01	-6.1	6.1	1.3e-09	-1.00	0.03	0.84	FALSE
5	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	-6.0	-6.0	1.9e-09	0.83	0.04	0.95	FALSE
6	GTEx	Colon Sigmoid	GPX1	0.12	0.07	enet	24	0.09	6.2e-04	-5.9	-5.6	1.7e-08	0.96	0.03	0.95	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	-5.9	-5.7	1.5e-08	0.91	0.03	0.96	FALSE
8	GTEx	Esophagus Mucosa	NICN1-AS1	0.08	0.06	enet	20	0.05	3.6e-04	-3.2	5.2	2.5e-07	-0.77	0.15	0.83	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	-6.1	6.1	9.5e-10	-0.92	0.04	0.95	FALSE
10	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	-6.0	-5.8	5.5e-09	0.85	0.04	0.96	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-5.9	-5.5	3.1e-08	0.78	0.01	0.62	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	-5.9	-6.0	1.5e-09	0.91	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NAT6	0.10	0.00	blup	14	0.03	1.4e-02	3.0	5.5	2.8e-08	0.00	0.00	0.00	TRUE
14	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-5.9	-5.2	2.2e-07	0.70	0.01	0.68	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	GMPPB	0.15	0.09	enet	12	0.09	1.3e-03	-5.9	-6.0	2.6e-09	0.98	0.01	0.80	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GMPPB	0.04	0.02	lasso	2	0.02	2.0e-03	-5.9	-5.2	1.5e-07	0.92	0.01	0.92	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMPPB	0.04	0.04	lasso	3	0.04	2.3e-05	-6.0	-6.0	2.1e-09	0.98	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMIGO3	0.11	0.09	enet	10	0.11	2.2e-12	-5.9	-5.7	1.5e-08	0.88	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMPPB	0.15	0.12	enet	17	0.13	1.2e-14	-5.9	-5.9	3.5e-09	0.92	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	-3.9	-5.2	2.1e-07	0.68	0.04	0.36	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	GMPPB	0.06	0.06	lasso	1	0.06	6.5e-08	-5.9	-5.9	2.8e-09	0.97	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GMPPB	0.03	0.02	enet	13	0.02	1.3e-03	-5.9	-5.5	4.1e-08	0.85	0.01	0.82	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	-3.9	-5.4	5.8e-08	0.76	0.02	0.52	FALSE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GMPPB	0.13	0.13	enet	10	0.12	1.6e-05	-5.9	-5.9	4.2e-09	0.98	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	-5.9	-5.9	2.9e-09	0.90	0.01	0.91	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	AMIGO3	0.26	0.34	lasso	9	0.34	1.5e-36	-5.9	-5.9	3.5e-09	0.98	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	GMPPB	0.38	0.53	lasso	9	0.53	1.2e-64	-5.9	-6.0	2.7e-09	0.98	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	IP6K1	0.03	0.04	blup	55	0.04	9.2e-05	-6.1	-6.1	1.4e-09	0.94	0.01	0.98	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	AMIGO3	0.08	0.07	blup	40	0.06	1.3e-06	-5.9	-6.1	1.0e-09	0.95	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	GMPPB	0.08	0.09	lasso	8	0.09	4.3e-09	-6.0	-6.1	8.8e-10	0.96	0.01	0.99	TRUE