TWAS
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About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Lung FEV1/FVC ratio
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chr3:51,860,817-54,093,832
Best TWAS P=6.01e-10 · Best GWAS P=7.55e-16 conditioned to 8.43e-08
52M
52.5M
53M
53.5M
54M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Adenocarcinoma
CACNA1D
0.04
0.02
enet
12
0.02
7.5e-04
-6.7
6.2
6.0e-10
-0.57
0.11
0.30
TRUE
3
ROSMAP
Brain Pre-frontal Cortex
GNL3
0.15
0.23
enet
16
0.22
2.0e-28
-4.7
-5.2
1.5e-07
0.03
0.03
0.96
TRUE
1
GTEx
Artery Tibial
PBRM1
0.16
0.20
enet
35
0.21
4.8e-16
4.3
5.2
2.0e-07
-0.02
0.15
0.80
FALSE
2
METSIM
Adipose
NT5DC2
0.27
0.13
enet
34
0.14
2.2e-20
-3.5
-5.2
2.6e-07
0.01
0.41
0.43
FALSE