Best TWAS P=6.01e-10 · Best GWAS P=7.55e-16 conditioned to 8.43e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PBRM1 | 0.16 | 0.20 | enet | 35 | 0.21 | 4.8e-16 | 4.3 | 5.2 | 2.0e-07 | -0.02 | 0.15 | 0.80 | FALSE |
| 2 | METSIM | Adipose | NT5DC2 | 0.27 | 0.13 | enet | 34 | 0.14 | 2.2e-20 | -3.5 | -5.2 | 2.6e-07 | 0.01 | 0.41 | 0.43 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | GNL3 | 0.15 | 0.23 | enet | 16 | 0.22 | 2.0e-28 | -4.7 | -5.2 | 1.5e-07 | 0.03 | 0.03 | 0.96 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | CACNA1D | 0.04 | 0.02 | enet | 12 | 0.02 | 7.5e-04 | -6.7 | 6.2 | 6.0e-10 | -0.57 | 0.11 | 0.30 | TRUE |