Hub : Genes

CACNA1D

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Brain Lower Grade Glioma 0.0618 0.0285 0.0046 0.004 0.002 -0.001 NA 0.000 0.0980 0.1600 0.53000 NA 0.290
2 TCGA Lung Adenocarcinoma 0.0356 0.0169 0.0063 0.016 0.016 0.024 NA 0.012 0.0051 0.0049 0.00075 NA 0.012

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 2.3 3.7 6.1 2.5 -1.1
Bipolar Disorder or Schizophrenia 0.1 0.3 0.3 0.5 -0.6
Depressed Affect (Nagel 2018) 0.3 0.6 1.1 1.1 0.3
Depression (Nagel 2018) 0.0 0.1 0.1 -0.1 -0.3
Intelligence (Savage-Jansen 2018) 2.1 6.4 12.5 0.5 -3.5
Neuroticism (Nagel 2018) 0.3 0.7 1.4 1.2 0.2
Schizophrenia (2018) 0.4 0.9 1.7 -1.3 0.2
Schizophrenia vs Biploar Disorder 2.0 2.7 4.3 -2.1 1.0
Worry (Nagel 2018) 0.6 1.3 2.4 1.5 -0.6
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.2 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.6 0.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.6 -0.2
Crohns Disease (2017) 0.3 0.6 0.9 0.5 -1.0
Irritable Bowel Disease (IBD) 1.2 2.9 3.7 1.4 -1.9
Ulcerative Colitis (UC) 1.1 2.0 2.5 1.2 -1.6
Major Depression (MDD) 0.1 0.1 0.1 0.2 -0.3
Reaction Time 0.1 0.1 0.1 -0.3 0.3
Verbal and Numeric Reasoning (VNR) 2.7 6.5 12.9 0.3 -3.6
Breast Cancer 0.1 0.1 0.3 -0.2 0.5
Ovarian Cancer 0.7 0.9 1.7 1.3 0.2
Prostate Cancer 0.6 0.8 1.5 -1.2 0.3
Age at First Birth 0.1 0.2 0.4 0.6 -0.1
Bipolar Disorder (2011) 3.5 3.4 5.3 2.3 -1.2
Body Mass Index (BMI) (2010) 0.0 0.0 0.0 -0.2 -0.1
Coronary Artery Disease (CAD) 1.3 1.6 2.7 1.6 -0.7
Crohns Disease (2012) 0.8 1.3 1.7 0.9 -1.3
Mean Putamen Volume 1.0 1.2 2.2 1.5 -0.3
Fasting Glucose 0.3 0.3 0.5 -0.7 0.4
HbA1C 0.3 0.4 0.6 0.4 -0.8
HDL Cholesterol 0.5 0.8 1.6 0.2 1.3
LDL Cholesterol 0.0 0.0 0.0 -0.2 0.0
Lupus 1.9 2.8 4.2 1.2 -2.0
Neuroticism (2016) 0.1 0.1 0.2 0.0 0.4
Primary Biliary Cirrhosis 0.3 0.4 0.8 0.1 -0.9
Rheumatoid Arthritis 0.2 0.2 0.3 -0.3 -0.6
Schizophrenia (2014) 0.2 0.4 0.6 -0.2 -0.8
Triglycerides 0.6 1.0 1.9 0.1 -1.4
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.4 -0.5 0.6
Ulcerative Colitis 1.8 2.6 3.1 1.5 -1.8
Blood Eosinophil Count 0.2 1.6 1.8 1.3 -1.2
Blood Platelet Count 0.0 0.0 0.0 0.2 -0.2
Blood Red Count 0.1 1.1 1.3 1.0 1.1
Blood White Count 0.0 0.3 0.7 0.0 -0.8
Heel T-Score 0.7 5.3 7.3 -2.7 1.8
BMI 0.5 2.9 5.7 0.2 -2.4
Height 0.5 9.4 9.5 3.0 -3.1
Waist Hip Ratio (WHR) 2.5 11.1 22.3 4.7 -0.0
Systolic Blood Pressure 1.3 6.6 13.1 -0.3 -3.6
Smoking Status 5.7 13.8 20.4 -4.5 2.7
Allergy or Eczema 0.2 0.6 0.7 0.7 -0.8
Cardiovascular Disease 3.3 11.1 21.1 1.0 -4.6
Hypothyroidism (self reported) 0.7 1.6 2.0 1.4 -1.1
Respiratory disease 0.0 0.1 0.2 0.4 -0.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 0.1 -0.6
Lung FEV1/FVC ratio 4.9 24.6 38.3 -3.3 6.2
Lung FVC 0.5 2.3 3.7 -0.9 1.9
Neuroticism 0.3 0.8 0.9 0.9 0.9
Chronotype (morning person) 2.1 4.8 5.1 -2.3 2.1
Hair Pigment 0.0 0.6 1.0 1.0 0.3
Tanning 0.1 0.9 1.8 -1.3 -0.3
Hand grip strength (left) 1.7 4.4 6.4 2.5 -1.6
Number of treatments/medications taken 1.8 3.3 6.5 0.2 -2.6
Average weekly spirits intake 1.3 1.6 2.4 -1.5 -0.8
Sensitivity / hurt feelings 0.5 0.8 1.2 0.7 1.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.4 -0.6 0.5
Hearing difficulty/problems: Yes 0.8 1.2 2.4 -0.0 1.5
Relative age of first facial hair 0.4 0.8 1.6 -0.2 1.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.0 0.4
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.9 -0.5 1.0
Ever had hysterectomy (womb removed) 0.0 0.0 0.1 0.2 0.1
Systolic blood pressure, automated reading 1.6 4.5 8.9 -0.5 -3.0
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.0 0.7 -1.4
Angina 0.0 0.1 0.1 -0.0 0.3
Medication for hormone replacement therapy 0.4 0.5 0.9 -0.9 0.0
Vitamin and mineral supplements 0.5 0.6 1.1 1.1 0.3
Supplements: Zinc 1.4 1.6 1.8 -1.4 1.1
Medication: Co-codamol 1.2 1.4 2.2 -0.8 1.5
Medication: Metformin 0.7 1.0 1.3 1.1 -0.9
Diabetes (father) 1.8 2.2 3.5 1.9 -1.0
Diabetes (mother) 0.6 0.7 1.5 0.0 1.2
Severe depression (siblings) 0.5 0.6 1.0 -0.4 1.0
Pack years adult smoking proportion 1.2 1.8 3.5 -0.3 1.9
Impedance of leg (right) 1.1 5.1 7.6 1.6 2.8
Leg fat-free mass (left) 1.0 5.3 10.0 0.7 -3.2
Trunk fat percentage 1.2 5.0 8.3 2.9 -1.3
Hand grip strength (right) 0.8 2.2 2.5 1.4 -1.6
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.0 -0.5
Current tobacco smoking 4.0 6.5 7.2 -2.4 2.7
Average weekly fortified wine intake 1.8 2.2 3.8 0.7 -1.9
Maternal smoking around birth 2.2 3.1 4.1 -1.5 2.0
Fed-up feelings 0.2 0.3 0.4 0.4 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 -0.1 -0.1
Relative age voice broke 0.1 0.1 0.1 -0.4 -0.3
Taking other prescription medications 4.5 7.0 7.5 2.7 -2.5
Age when periods started (menarche) 4.5 10.9 13.0 -3.6 3.0
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.2 -0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 5.7 -2.4 1.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.3 0.5
Qualifications: CSEs or equivalent 0.1 0.1 0.2 -0.1 0.4
Serious illness, injury or assault to yourself 0.5 0.7 0.9 -0.6 0.9
High blood pressure 2.8 7.9 15.8 0.3 -4.0
Hayfever, allergic rhinitis or eczema 0.5 1.2 1.9 1.4 -0.7
Multivitamins +/- minerals 0.9 1.2 2.4 -1.5 -0.2
Stomach or abdominal pain in last month 1.6 2.0 3.7 0.5 1.9
Supplements: Glucosamine 0.0 0.1 0.1 -0.0 0.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.5 -0.3 1.6
Medication: Atenolol 2.9 3.6 4.0 2.0 -1.8
Medication: Levothyroxine sodium 0.7 1.2 1.9 1.4 -0.6
Sitting height 0.7 4.8 7.1 1.6 -2.7
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 -0.2 -0.4
High blood pressure (mother) 0.1 0.2 0.3 0.6 0.2
Body mass index (BMI) 0.4 1.6 3.2 0.3 -1.8
Impedance of leg (left) 1.2 5.9 8.9 1.7 3.0
Leg predicted mass (left) 1.1 5.7 10.7 0.8 -3.3
Trunk fat mass 1.0 4.1 5.8 2.4 -1.6
Waist circumference 0.9 3.3 4.1 2.0 -1.6
Number of incorrect matches in round 0.4 0.7 1.3 1.1 -0.1
Past tobacco smoking 2.2 4.1 5.8 2.4 -1.5
Alcohol usually taken with meals 0.4 0.7 1.4 -0.0 -1.2
Nervous feelings 0.5 0.8 1.4 1.2 0.5
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.1 -0.4 1.8
Hearing difficulty/problems with background noise 0.2 0.3 0.5 0.2 -0.7
Hair/balding pattern: Pattern 2 2.3 2.9 4.0 -2.0 1.3
Had menopause 0.1 0.1 0.2 0.0 -0.5
Had other major operations 0.9 1.2 2.3 0.2 -1.5
Forced vital capacity (FVC) 0.4 1.4 2.7 0.1 1.7
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.3 4.1 -2.0 1.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.5 0.7 -0.3
Qualifications: None of the above 1.4 3.0 4.0 -2.0 1.4
Financial difficulties in last 2 years 1.6 2.1 3.8 -0.7 2.0
Mouth/teeth dental problems 0.3 0.5 1.1 -1.0 -0.0
Heart attack 1.4 1.8 2.9 1.7 -0.8
Allergy 0.4 1.0 1.8 -1.3 0.5
Pain all over the body in last month 1.2 1.3 2.1 -0.7 1.5
Diabetes (self-reported) 1.2 1.9 2.8 1.0 -1.7
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 1.9 -0.4 1.4
Medication: Ramipril 0.7 0.9 1.8 -1.3 0.1
Medication: Simvastatin 0.3 0.4 0.5 -0.5 0.7
Fluid intelligence score 2.2 4.6 8.0 1.1 -2.8
Illnesses of siblings 0.2 0.3 0.6 0.0 0.7
Neuroticism score 0.4 0.9 1.2 1.1 0.7
Weight 0.6 3.0 4.8 1.1 -2.2
Impedance of arm (right) 0.9 4.0 6.8 2.6 1.1
Arm fat percentage (right) 0.7 2.9 3.7 1.9 -1.4
Trunk fat-free mass 0.2 1.4 2.7 -0.4 -1.6
Hip circumference 0.3 1.4 2.7 -0.4 -1.7
Time employed in main current job 0.3 0.4 0.7 -0.2 -0.9
Alcohol intake versus 10 years previously 4.5 6.7 9.8 3.1 -1.9
Father’s age at death 0.3 0.4 0.8 0.9 0.1
Worrier / anxious feelings 0.2 0.3 0.4 -0.5 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 1.7 1.3 -1.1
Falls in the last year 0.1 0.1 0.2 -0.5 -0.2
Hair/balding pattern: Pattern 3 0.0 0.1 0.1 0.4 -0.1
Number of live births 0.5 0.7 1.5 -1.2 0.1
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 7.1 -0.6 2.7
Pulse rate 0.6 1.1 1.4 1.2 -0.8
Happiness 0.0 0.0 0.0 -0.0 0.1
Noisy workplace 0.0 0.1 0.1 0.1 -0.3
Qualifications: A levels/AS levels or equivalent 2.2 5.0 5.1 2.2 -2.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 1.3 1.1 -0.9
Mouth/teeth dental problems: Dentures 0.4 0.6 0.9 1.0 -0.5
Asthma 0.0 0.0 0.1 -0.1 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.7 0.1 -1.3
Medication: Cholesterol lowering 0.0 0.1 0.1 -0.3 0.2
Depression (self-reported) 0.2 0.2 0.4 0.6 -0.3
Medication: Lansoprazole 0.1 0.1 0.2 0.2 -0.5
Prospective memory result 1.3 1.6 3.3 0.1 1.8
Lung cancer (father) 1.1 1.3 1.4 1.0 -1.2
Illnesses of mother 2.6 3.2 4.0 1.5 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 3.0 5.9 -0.3 2.4
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 0.8 -0.2
Impedance of arm (left) 1.1 5.0 9.6 3.1 0.6
Arm fat mass (right) 0.8 3.4 3.7 1.8 -1.9
Trunk predicted mass 0.3 1.4 2.7 -0.4 -1.6
Standing height 0.3 3.0 4.5 2.1 -1.2
Length of working week for main job 0.4 0.5 0.8 0.5 -0.9
Exposure to tobacco smoke at home 2.9 3.2 5.7 -0.9 2.4
Breastfed as a baby 0.2 0.3 0.4 -0.7 0.3
Tense / ‘highly strung’ 0.3 0.5 0.5 -0.6 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.0 1.4 -0.5
Hair/balding pattern: Pattern 4 0.0 0.0 0.1 0.0 -0.3
Birth weight of first child 1.5 2.8 4.9 2.2 -0.8
Peak expiratory flow (PEF) 1.2 2.7 4.6 -0.9 2.1
Pulse wave reflection index 0.5 0.6 1.1 -1.1 0.2
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.0 0.1 0.0
Loud music exposure frequency 0.8 0.9 1.1 0.8 1.1
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 2.8 1.1 -1.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.1 0.3 -0.4
Blood clot in the leg (DVT) 2.2 2.9 5.3 -2.3 0.7
Medication: Paracetamol 0.1 0.1 0.1 0.3 0.4
Headache pain in last month 1.5 2.6 5.2 2.3 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.7 0.1 1.3
Glaucoma (self-reported) 0.2 0.3 0.5 0.1 0.7
Gout (self-reported) 1.0 1.4 2.1 -0.9 1.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 0.8 0.9 -0.8
Medication: Amlodipine 1.1 1.5 1.8 -1.1 -1.3
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.4 0.7 -0.2
Birth weight 0.1 0.2 0.3 0.5 0.4
Chronic bronchitis/emphysema (mother) 1.5 1.7 2.7 -0.9 1.6
High blood pressure (siblings) 0.4 0.6 1.3 -0.0 -1.1
Forced vital capacity (FVC), Best measure 0.2 0.9 1.4 0.7 1.2
Body fat percentage 0.8 3.1 4.7 2.2 -1.2
Leg fat percentage (right) 0.2 0.6 0.8 0.9 -0.6
Arm fat-free mass (right) 0.2 1.3 2.4 -0.4 -1.5
Exposure to tobacco smoke outside home 0.1 0.2 0.3 0.6 -0.1
Comparative body size at age 10 0.1 0.2 0.4 0.6 -0.1
Number of full brothers 0.7 0.8 1.1 -0.7 1.1
Worry too long after embarrassment 0.3 0.4 0.7 0.9 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.3 0.6 0.4
Wheeze or whistling in the chest in last year 0.8 1.4 2.7 -0.3 1.6
Number of children fathered 0.4 0.5 0.9 -1.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.5 -0.7 -0.5
Age at first live birth 1.9 3.3 3.9 2.0 -1.7
Pulse wave peak to peak time 0.1 0.2 0.2 -0.5 0.3
Health satisfaction 0.0 0.0 0.0 0.1 0.0
Shortness of breath walking on level ground 0.4 0.5 0.9 -0.9 0.3
Qualifications: College or University degree 1.2 3.7 7.3 2.7 -0.3
Eye problems/disorders: None of the above 3.1 3.5 3.7 -1.9 1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 -0.1 0.8
Emphysema/chronic bronchitis 0.0 0.0 0.0 -0.1 0.1
Medication for pain relief, constipation, heartburn 0.0 0.1 0.1 0.1 0.4
Neck or shoulder pain in last month 0.3 0.4 0.6 -0.8 0.5
Medication: Blood pressure 1.4 2.6 4.8 0.5 -2.2
Angina (self-reported) 0.0 0.0 0.1 0.2 0.2
Migraine (self-reported) 1.2 1.5 1.9 1.4 1.1
Medication: Ibuprofen 0.9 1.1 1.8 -0.7 -1.3
Medication: Allopurinol 2.0 2.6 3.6 -1.3 1.9
Medication: Omeprazole 0.1 0.1 0.1 -0.3 0.0
Medication: Seretide 50 evohaler 0.4 0.5 0.8 0.4 0.9
Mean time to correctly identify matches 0.1 0.1 0.3 -0.5 -0.1
Heart disease (mother) 0.7 0.9 1.4 -1.2 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 2.8 -1.7 -0.5
Whole body fat mass 0.7 2.8 3.1 1.8 -1.6
Leg fat mass (right) 0.6 2.2 2.5 1.4 -1.6
Arm predicted mass (right) 0.4 1.9 3.7 -0.3 -1.9
Pulse rate, automated reading 3.1 10.1 11.2 3.3 -3.0
Alcohol intake frequency. 4.5 10.4 18.4 4.3 -1.6
Comparative height size at age 10 0.3 1.4 2.2 0.8 -1.5
Number of full sisters 0.4 0.4 0.5 -0.6 0.7
Suffer from ‘nerves’ 0.6 0.9 1.8 1.4 0.1
Overall health rating 0.9 2.0 3.6 1.9 -0.6
Chest pain or discomfort 0.9 1.3 2.5 1.6 -0.1
Had major operations 0.0 0.1 0.1 -0.1 -0.3
Age at last live birth 0.6 0.8 1.3 1.1 -0.6
Family relationship satisfaction 1.6 1.9 2.2 -1.3 1.5
Leg pain on walking 0.3 0.4 0.7 0.8 -0.3
Qualifications: NVQ or HND or HNC or equivalent 4.0 4.8 7.9 2.8 -1.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 0.9 0.9 -0.8
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.1 -1.0 -0.8
Medication: Aspirin 0.0 0.0 0.0 0.1 0.1
Supplements: Vitamin C 0.6 0.7 1.0 -1.0 -0.6
Knee pain experienced in last month 0.8 1.3 2.4 -1.5 0.3
Hypertension (Self-reported) 2.9 8.2 16.3 0.1 -4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 3.7 1.3 -1.9
Illnesses of father: Heart disease 0.3 0.5 0.9 -0.1 -1.0
Illnesses of siblings: Diabetes 0.5 0.7 0.7 -0.8 0.8
Smoking status: Previous 0.6 0.9 1.5 -1.2 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 2.7 1.6 -1.2
Whole body fat-free mass 0.4 2.5 5.0 -0.0 -2.2
Leg fat-free mass (right) 0.9 4.8 9.5 0.5 -3.1
Arm fat percentage (left) 1.0 3.8 4.6 2.1 -1.7
Average weekly red wine intake 1.7 2.5 3.7 -1.9 -1.2
Handedness (chirality/laterality): Left-handed 0.6 0.8 1.2 0.6 1.1
Mood swings 0.3 0.6 1.1 -0.1 1.1
Loneliness, isolation 0.3 0.4 0.5 -0.6 0.7
Long-standing illness, disability or infirmity 0.4 0.7 1.3 1.1 -0.3
Ever had bowel cancer screening 0.3 0.3 0.6 -0.8 0.2
Diabetes diagnosed by doctor 0.4 0.7 1.2 0.4 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.3 -1.0 1.1
Friendships satisfaction 0.2 0.3 0.5 0.1 -0.7
Qualifications: nursing, teaching 2.3 3.6 4.7 1.6 -2.2
Commuting to job workplace: Walk 0.2 0.2 0.4 -0.6 0.0
Eye problems/disorders: Cataract 1.7 2.0 2.3 1.5 -1.3
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.2 0.3
Medication for cholesterol 4.1 6.2 12.2 -0.6 3.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.5 -0.7 0.2
Back pain experienced in last month 0.2 0.3 0.3 0.5 -0.6
Mineral and other dietary supplements 0.3 0.5 0.8 0.9 0.3
Breast cancer (self-reported) 1.9 2.2 3.4 1.0 -1.8
Asthma (self-reported) 0.1 0.1 0.2 0.3 0.4
Osteoporosis (self-reported) 0.5 0.6 1.0 1.0 -0.5
Osteoarthritis (self-reported) 1.1 1.5 2.9 0.2 -1.7
Medication: Aspirin 0.0 0.0 0.0 -0.2 -0.1
Medication: Gliclazide 1.3 1.5 2.6 0.6 -1.6
Illnesses of father: None of the above (group 1) 0.3 0.3 0.5 0.4 0.7
Smoking status: Current 4.9 7.7 8.8 -2.6 3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 4.8 -0.8 2.2
Whole body water mass 0.5 2.7 5.4 -0.0 -2.3
Leg predicted mass (right) 0.9 4.6 9.0 0.5 -3.0
Arm fat mass (left) 0.8 3.4 4.0 1.7 -2.0
Number of self-reported non-cancer illnesses 0.0 0.1 0.1 -0.3 -0.1
Average weekly champagne plus white wine intake 0.4 0.5 0.8 0.4 -0.9
Miserableness 0.5 0.9 1.6 0.5 1.3
Guilty feelings 0.4 0.6 0.9 -0.5 1.0
Wears glasses or contact lenses 3.0 3.4 4.3 1.6 -2.1
Ever taken oral contraceptive pill 0.4 0.4 0.7 0.4 0.9
Hearing aid user 3.5 3.9 6.2 -2.5 1.3
Mother’s age at death 0.1 0.1 0.2 0.1 0.4
Financial situation satisfaction 0.0 0.1 0.1 0.3 0.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.4 -0.3
Commuting to job workplace: Public transport 1.5 1.8 2.1 -1.4 1.2
Eye problems/disorders: Glaucoma 0.3 0.4 0.7 0.8 0.2
Medication: Blood pressure 4.7 8.9 16.8 1.0 -4.1
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.2 -0.4 0.5
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.0 -1.0 -0.3
High cholesterol (Self-reported) 0.1 0.1 0.2 -0.2 -0.5
Medication: Bendroflumethiazide 4.7 7.1 13.8 0.7 -3.7
Medication: Paracetamol 0.0 0.0 0.1 -0.3 0.1
Medication: Lisinopril 0.3 0.3 0.5 -0.7 -0.5
Medication: Atorvastatin 0.7 0.9 1.6 0.4 -1.3
Illnesses of father: High blood pressure 0.6 0.7 0.9 -0.7 -1.0
Alcohol drinker status: Never 3.2 3.9 5.8 2.4 -1.4
Ever smoked 2.8 4.9 6.7 -2.6 1.8
Basal metabolic rate 0.5 2.7 5.4 0.3 -2.3
Leg fat percentage (left) 0.2 0.6 1.0 1.0 -0.5
Arm fat-free mass (left) 0.4 1.8 3.6 -0.2 -1.9
Number of operations (self-reported) 0.4 0.6 1.1 -1.0 0.4
Average weekly beer plus cider intake 0.1 0.2 0.3 0.5 0.4
Irritability 0.8 1.3 2.0 -0.7 1.4
Risk taking 1.8 2.6 3.8 -1.2 2.0
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.4 -0.3 0.7
Fractured/broken bones in last 5 years 0.5 0.7 0.9 -0.7 -0.9
Age started oral contraceptive pill 0.1 0.1 0.2 -0.4 -0.2
Diastolic blood pressure, automated reading 2.1 6.4 10.6 1.5 -3.3
Ever depressed for a whole week 0.9 1.2 2.1 1.5 -0.4
Unable to work because of sickness or disability 0.3 0.3 0.7 -0.1 0.8
Commuting to job workplace: Cycle 0.9 1.1 2.2 0.2 -1.5
Myopia 0.3 0.4 0.7 0.8 0.3
Vascular/heart problems diagnosed by doctor 2.1 5.8 11.6 -0.2 3.4
Cholesterol lowering medication 0.4 0.6 1.0 1.0 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 0.1 -0.2
Pain experienced in last month 0.3 0.5 0.9 -1.0 -0.4
Supplements: Calcium 1.3 1.4 2.2 0.7 -1.5
Basal cell carcinoma (self-reported) 1.3 1.6 2.4 -0.9 1.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.8 1.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 3.2 4.1 7.1 -2.7 1.0
Heart disease (siblings) 0.4 0.5 1.0 1.0 0.1
Alcohol drinker status: Previous 0.1 0.1 0.2 0.4 0.3
Pack years of smoking 1.2 1.8 3.3 -0.5 1.8
Impedance of whole body 1.1 5.4 8.0 2.8 1.7
Leg fat mass (left) 0.6 2.5 2.9 1.4 -1.7
Arm predicted mass (left) 0.3 1.5 2.7 -0.6 -1.6