TWAS hub - CACNA1D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0618	0.0285	0.0046	0.004	0.002	-0.001	NA	0.000	0.0980	0.1600	0.53000	NA	0.290
2	TCGA	Lung Adenocarcinoma	0.0356	0.0169	0.0063	0.016	0.016	0.024	NA	0.012	0.0051	0.0049	0.00075	NA	0.012

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Smoking Status	5.7	13.8	20.4	-4.5	2.7
Lung FEV1/FVC ratio	4.9	24.6	38.3	-3.3	6.2
Smoking status: Current	4.9	7.7	8.8	-2.6	3.0
Medication: Blood pressure	4.7	8.9	16.8	1.0	-4.1
Medication: Bendroflumethiazide	4.7	7.1	13.8	0.7	-3.7
Taking other prescription medications	4.5	7.0	7.5	2.7	-2.5
Age when periods started (menarche)	4.5	10.9	13.0	-3.6	3.0
Alcohol intake versus 10 years previously	4.5	6.7	9.8	3.1	-1.9
Alcohol intake frequency.	4.5	10.4	18.4	4.3	-1.6
Medication for cholesterol	4.1	6.2	12.2	-0.6	3.5
Current tobacco smoking	4.0	6.5	7.2	-2.4	2.7
Qualifications: NVQ or HND or HNC or equivalent	4.0	4.8	7.9	2.8	-1.3
Bipolar Disorder (2011)	3.5	3.4	5.3	2.3	-1.2
Hearing aid user	3.5	3.9	6.2	-2.5	1.3
Cardiovascular Disease	3.3	11.1	21.1	1.0	-4.6
Alcohol drinker status: Never	3.2	3.9	5.8	2.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	3.2	4.1	7.1	-2.7	1.0
Eye problems/disorders: None of the above	3.1	3.5	3.7	-1.9	1.8
Pulse rate, automated reading	3.1	10.1	11.2	3.3	-3.0
Wears glasses or contact lenses	3.0	3.4	4.3	1.6	-2.1
Medication: Atenolol	2.9	3.6	4.0	2.0	-1.8
Exposure to tobacco smoke at home	2.9	3.2	5.7	-0.9	2.4
Hypertension (Self-reported)	2.9	8.2	16.3	0.1	-4.0
High blood pressure	2.8	7.9	15.8	0.3	-4.0
Ever smoked	2.8	4.9	6.7	-2.6	1.8
Verbal and Numeric Reasoning (VNR)	2.7	6.5	12.9	0.3	-3.6
Illnesses of mother	2.6	3.2	4.0	1.5	-2.0
Waist Hip Ratio (WHR)	2.5	11.1	22.3	4.7	-0.0
Bipolar Disorder (2018)	2.3	3.7	6.1	2.5	-1.1
Hair/balding pattern: Pattern 2	2.3	2.9	4.0	-2.0	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	3.7	1.3	-1.9
Qualifications: nursing, teaching	2.3	3.6	4.7	1.6	-2.2
Maternal smoking around birth	2.2	3.1	4.1	-1.5	2.0
Past tobacco smoking	2.2	4.1	5.8	2.4	-1.5
Fluid intelligence score	2.2	4.6	8.0	1.1	-2.8
Qualifications: A levels/AS levels or equivalent	2.2	5.0	5.1	2.2	-2.2
Blood clot in the leg (DVT)	2.2	2.9	5.3	-2.3	0.7
Intelligence (Savage-Jansen 2018)	2.1	6.4	12.5	0.5	-3.5
Chronotype (morning person)	2.1	4.8	5.1	-2.3	2.1
Diastolic blood pressure, automated reading	2.1	6.4	10.6	1.5	-3.3
Vascular/heart problems diagnosed by doctor	2.1	5.8	11.6	-0.2	3.4
Schizophrenia vs Biploar Disorder	2.0	2.7	4.3	-2.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	5.7	-2.4	1.9
Medication: Allopurinol	2.0	2.6	3.6	-1.3	1.9
Lupus	1.9	2.8	4.2	1.2	-2.0
Age at first live birth	1.9	3.3	3.9	2.0	-1.7
Breast cancer (self-reported)	1.9	2.2	3.4	1.0	-1.8
Ulcerative Colitis	1.8	2.6	3.1	1.5	-1.8
Number of treatments/medications taken	1.8	3.3	6.5	0.2	-2.6
Diabetes (father)	1.8	2.2	3.5	1.9	-1.0
Average weekly fortified wine intake	1.8	2.2	3.8	0.7	-1.9
Risk taking	1.8	2.6	3.8	-1.2	2.0
Hand grip strength (left)	1.7	4.4	6.4	2.5	-1.6
Average weekly red wine intake	1.7	2.5	3.7	-1.9	-1.2
Eye problems/disorders: Cataract	1.7	2.0	2.3	1.5	-1.3
Systolic blood pressure, automated reading	1.6	4.5	8.9	-0.5	-3.0
Stomach or abdominal pain in last month	1.6	2.0	3.7	0.5	1.9
Financial difficulties in last 2 years	1.6	2.1	3.8	-0.7	2.0
Family relationship satisfaction	1.6	1.9	2.2	-1.3	1.5
Birth weight of first child	1.5	2.8	4.9	2.2	-0.8
Headache pain in last month	1.5	2.6	5.2	2.3	0.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.7	-0.9	1.6
Commuting to job workplace: Public transport	1.5	1.8	2.1	-1.4	1.2
Supplements: Zinc	1.4	1.6	1.8	-1.4	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	4.1	-2.0	1.6
Qualifications: None of the above	1.4	3.0	4.0	-2.0	1.4
Heart attack	1.4	1.8	2.9	1.7	-0.8
Medication: Blood pressure	1.4	2.6	4.8	0.5	-2.2
Coronary Artery Disease (CAD)	1.3	1.6	2.7	1.6	-0.7
Systolic Blood Pressure	1.3	6.6	13.1	-0.3	-3.6
Average weekly spirits intake	1.3	1.6	2.4	-1.5	-0.8
Prospective memory result	1.3	1.6	3.3	0.1	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.8	-1.7	-0.5
Medication: Gliclazide	1.3	1.5	2.6	0.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.8	-0.8	2.2
Supplements: Calcium	1.3	1.4	2.2	0.7	-1.5
Basal cell carcinoma (self-reported)	1.3	1.6	2.4	-0.9	1.5
Irritable Bowel Disease (IBD)	1.2	2.9	3.7	1.4	-1.9
Medication: Co-codamol	1.2	1.4	2.2	-0.8	1.5
Pack years adult smoking proportion	1.2	1.8	3.5	-0.3	1.9
Trunk fat percentage	1.2	5.0	8.3	2.9	-1.3
Impedance of leg (left)	1.2	5.9	8.9	1.7	3.0
Pain all over the body in last month	1.2	1.3	2.1	-0.7	1.5
Diabetes (self-reported)	1.2	1.9	2.8	1.0	-1.7
Peak expiratory flow (PEF)	1.2	2.7	4.6	-0.9	2.1
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	2.8	1.1	-1.7
Qualifications: College or University degree	1.2	3.7	7.3	2.7	-0.3
Migraine (self-reported)	1.2	1.5	1.9	1.4	1.1
Pack years of smoking	1.2	1.8	3.3	-0.5	1.8
Ulcerative Colitis (UC)	1.1	2.0	2.5	1.2	-1.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.0	0.7	-1.4
Impedance of leg (right)	1.1	5.1	7.6	1.6	2.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.5	-0.3	1.6
Leg predicted mass (left)	1.1	5.7	10.7	0.8	-3.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.1	-0.4	1.8
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	7.1	-0.6	2.7
Lung cancer (father)	1.1	1.3	1.4	1.0	-1.2
Impedance of arm (left)	1.1	5.0	9.6	3.1	0.6
Medication: Amlodipine	1.1	1.5	1.8	-1.1	-1.3
Osteoarthritis (self-reported)	1.1	1.5	2.9	0.2	-1.7
Impedance of whole body	1.1	5.4	8.0	2.8	1.7
Mean Putamen Volume	1.0	1.2	2.2	1.5	-0.3
Leg fat-free mass (left)	1.0	5.3	10.0	0.7	-3.2
Trunk fat mass	1.0	4.1	5.8	2.4	-1.6
Gout (self-reported)	1.0	1.4	2.1	-0.9	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.7	1.6	-1.2
Arm fat percentage (left)	1.0	3.8	4.6	2.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.3	-1.0	1.1
Multivitamins +/- minerals	0.9	1.2	2.4	-1.5	-0.2
Waist circumference	0.9	3.3	4.1	2.0	-1.6
Had other major operations	0.9	1.2	2.3	0.2	-1.5
Impedance of arm (right)	0.9	4.0	6.8	2.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	1.7	1.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.3	1.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	5.9	-0.3	2.4
Medication: Ibuprofen	0.9	1.1	1.8	-0.7	-1.3
Overall health rating	0.9	2.0	3.6	1.9	-0.6
Chest pain or discomfort	0.9	1.3	2.5	1.6	-0.1
Leg fat-free mass (right)	0.9	4.8	9.5	0.5	-3.1
Leg predicted mass (right)	0.9	4.6	9.0	0.5	-3.0
Ever depressed for a whole week	0.9	1.2	2.1	1.5	-0.4
Commuting to job workplace: Cycle	0.9	1.1	2.2	0.2	-1.5
Crohns Disease (2012)	0.8	1.3	1.7	0.9	-1.3
Hearing difficulty/problems: Yes	0.8	1.2	2.4	-0.0	1.5
Hand grip strength (right)	0.8	2.2	2.5	1.4	-1.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.9	-0.4	1.4
Arm fat mass (right)	0.8	3.4	3.7	1.8	-1.9
Loud music exposure frequency	0.8	0.9	1.1	0.8	1.1
Body fat percentage	0.8	3.1	4.7	2.2	-1.2
Wheeze or whistling in the chest in last year	0.8	1.4	2.7	-0.3	1.6
Knee pain experienced in last month	0.8	1.3	2.4	-1.5	0.3
Arm fat mass (left)	0.8	3.4	4.0	1.7	-2.0
Irritability	0.8	1.3	2.0	-0.7	1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.8	1.3	-0.4
Ovarian Cancer	0.7	0.9	1.7	1.3	0.2
Heel T-Score	0.7	5.3	7.3	-2.7	1.8
Hypothyroidism (self reported)	0.7	1.6	2.0	1.4	-1.1
Medication: Metformin	0.7	1.0	1.3	1.1	-0.9
Medication: Levothyroxine sodium	0.7	1.2	1.9	1.4	-0.6
Sitting height	0.7	4.8	7.1	1.6	-2.7
Medication: Ramipril	0.7	0.9	1.8	-1.3	0.1
Arm fat percentage (right)	0.7	2.9	3.7	1.9	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.7	0.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.0	1.4	-0.5
Number of full brothers	0.7	0.8	1.1	-0.7	1.1
Heart disease (mother)	0.7	0.9	1.4	-1.2	-0.6
Whole body fat mass	0.7	2.8	3.1	1.8	-1.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	0.9	0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.1	-1.0	-0.8
Medication: Atorvastatin	0.7	0.9	1.6	0.4	-1.3
Worry (Nagel 2018)	0.6	1.3	2.4	1.5	-0.6
Prostate Cancer	0.6	0.8	1.5	-1.2	0.3
Triglycerides	0.6	1.0	1.9	0.1	-1.4
Diabetes (mother)	0.6	0.7	1.5	0.0	1.2
Weight	0.6	3.0	4.8	1.1	-2.2
Pulse rate	0.6	1.1	1.4	1.2	-0.8
Leg fat mass (right)	0.6	2.2	2.5	1.4	-1.6
Suffer from ‘nerves’	0.6	0.9	1.8	1.4	0.1
Age at last live birth	0.6	0.8	1.3	1.1	-0.6
Supplements: Vitamin C	0.6	0.7	1.0	-1.0	-0.6
Smoking status: Previous	0.6	0.9	1.5	-1.2	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.2	0.6	1.1
Illnesses of father: High blood pressure	0.6	0.7	0.9	-0.7	-1.0
Leg fat mass (left)	0.6	2.5	2.9	1.4	-1.7
HDL Cholesterol	0.5	0.8	1.6	0.2	1.3
BMI	0.5	2.9	5.7	0.2	-2.4
Height	0.5	9.4	9.5	3.0	-3.1
Lung FVC	0.5	2.3	3.7	-0.9	1.9
Sensitivity / hurt feelings	0.5	0.8	1.2	0.7	1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	0.9	-0.5	1.0
Vitamin and mineral supplements	0.5	0.6	1.1	1.1	0.3
Severe depression (siblings)	0.5	0.6	1.0	-0.4	1.0
Serious illness, injury or assault to yourself	0.5	0.7	0.9	-0.6	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.9	1.4	-0.7
Nervous feelings	0.5	0.8	1.4	1.2	0.5
Number of live births	0.5	0.7	1.5	-1.2	0.1
Pulse wave reflection index	0.5	0.6	1.1	-1.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.7	0.1	1.3
Illnesses of siblings: Diabetes	0.5	0.7	0.7	-0.8	0.8
Osteoporosis (self-reported)	0.5	0.6	1.0	1.0	-0.5
Whole body water mass	0.5	2.7	5.4	-0.0	-2.3
Miserableness	0.5	0.9	1.6	0.5	1.3
Basal metabolic rate	0.5	2.7	5.4	0.3	-2.3
Fractured/broken bones in last 5 years	0.5	0.7	0.9	-0.7	-0.9
Schizophrenia (2018)	0.4	0.9	1.7	-1.3	0.2
Relative age of first facial hair	0.4	0.8	1.6	-0.2	1.3
Medication for hormone replacement therapy	0.4	0.5	0.9	-0.9	0.0
Body mass index (BMI)	0.4	1.6	3.2	0.3	-1.8
Number of incorrect matches in round	0.4	0.7	1.3	1.1	-0.1
Alcohol usually taken with meals	0.4	0.7	1.4	-0.0	-1.2
Forced vital capacity (FVC)	0.4	1.4	2.7	0.1	1.7
Allergy	0.4	1.0	1.8	-1.3	0.5
Neuroticism score	0.4	0.9	1.2	1.1	0.7
Mouth/teeth dental problems: Dentures	0.4	0.6	0.9	1.0	-0.5
Length of working week for main job	0.4	0.5	0.8	0.5	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	0.8	0.9	-0.8
High blood pressure (siblings)	0.4	0.6	1.3	-0.0	-1.1
Number of children fathered	0.4	0.5	0.9	-1.0	-0.1
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.9	0.3
Medication: Seretide 50 evohaler	0.4	0.5	0.8	0.4	0.9
Arm predicted mass (right)	0.4	1.9	3.7	-0.3	-1.9
Number of full sisters	0.4	0.4	0.5	-0.6	0.7
Whole body fat-free mass	0.4	2.5	5.0	-0.0	-2.2
Long-standing illness, disability or infirmity	0.4	0.7	1.3	1.1	-0.3
Diabetes diagnosed by doctor	0.4	0.7	1.2	0.4	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	0.8	0.4	-0.9
Guilty feelings	0.4	0.6	0.9	-0.5	1.0
Ever taken oral contraceptive pill	0.4	0.4	0.7	0.4	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.0	-1.0	-0.3
Arm fat-free mass (left)	0.4	1.8	3.6	-0.2	-1.9
Number of operations (self-reported)	0.4	0.6	1.1	-1.0	0.4
Cholesterol lowering medication	0.4	0.6	1.0	1.0	-0.4
Heart disease (siblings)	0.4	0.5	1.0	1.0	0.1
Depressed Affect (Nagel 2018)	0.3	0.6	1.1	1.1	0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.4	1.2	0.2
Crohns Disease (2017)	0.3	0.6	0.9	0.5	-1.0
Fasting Glucose	0.3	0.3	0.5	-0.7	0.4
HbA1C	0.3	0.4	0.6	0.4	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.1	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	-0.5	0.6
Neuroticism	0.3	0.8	0.9	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.5	0.7	-0.3
Mouth/teeth dental problems	0.3	0.5	1.1	-1.0	-0.0
Medication: Simvastatin	0.3	0.4	0.5	-0.5	0.7
Hip circumference	0.3	1.4	2.7	-0.4	-1.7
Time employed in main current job	0.3	0.4	0.7	-0.2	-0.9
Father’s age at death	0.3	0.4	0.8	0.9	0.1
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.8	-0.2
Trunk predicted mass	0.3	1.4	2.7	-0.4	-1.6
Standing height	0.3	3.0	4.5	2.1	-1.2
Tense / ‘highly strung’	0.3	0.5	0.5	-0.6	0.7
Worry too long after embarrassment	0.3	0.4	0.7	0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.5	-0.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.1	0.8
Neck or shoulder pain in last month	0.3	0.4	0.6	-0.8	0.5
Comparative height size at age 10	0.3	1.4	2.2	0.8	-1.5
Leg pain on walking	0.3	0.4	0.7	0.8	-0.3
Illnesses of father: Heart disease	0.3	0.5	0.9	-0.1	-1.0
Mood swings	0.3	0.6	1.1	-0.1	1.1
Loneliness, isolation	0.3	0.4	0.5	-0.6	0.7
Ever had bowel cancer screening	0.3	0.3	0.6	-0.8	0.2
Mineral and other dietary supplements	0.3	0.5	0.8	0.9	0.3
Illnesses of father: None of the above (group 1)	0.3	0.3	0.5	0.4	0.7
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.8	0.2
Medication: Lisinopril	0.3	0.3	0.5	-0.7	-0.5
Unable to work because of sickness or disability	0.3	0.3	0.7	-0.1	0.8
Myopia	0.3	0.4	0.7	0.8	0.3
Pain experienced in last month	0.3	0.5	0.9	-1.0	-0.4
Arm predicted mass (left)	0.3	1.5	2.7	-0.6	-1.6
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.6	0.3
Rheumatoid Arthritis	0.2	0.2	0.3	-0.3	-0.6
Schizophrenia (2014)	0.2	0.4	0.6	-0.2	-0.8
Blood Eosinophil Count	0.2	1.6	1.8	1.3	-1.2
Allergy or Eczema	0.2	0.6	0.7	0.7	-0.8
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	0.5
Fed-up feelings	0.2	0.3	0.4	0.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.2	-0.4	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.2	-0.7
Illnesses of siblings	0.2	0.3	0.6	0.0	0.7
Trunk fat-free mass	0.2	1.4	2.7	-0.4	-1.6
Worrier / anxious feelings	0.2	0.3	0.4	-0.5	0.7
Depression (self-reported)	0.2	0.2	0.4	0.6	-0.3
Breastfed as a baby	0.2	0.3	0.4	-0.7	0.3
Glaucoma (self-reported)	0.2	0.3	0.5	0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.7	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.9	1.4	0.7	1.2
Leg fat percentage (right)	0.2	0.6	0.8	0.9	-0.6
Arm fat-free mass (right)	0.2	1.3	2.4	-0.4	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.6	0.4
Friendships satisfaction	0.2	0.3	0.5	0.1	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.5	-0.7	0.2
Back pain experienced in last month	0.2	0.3	0.3	0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.2	-0.4	0.5
Leg fat percentage (left)	0.2	0.6	1.0	1.0	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	-0.3	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.3	0.5	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	-0.2
Major Depression (MDD)	0.1	0.1	0.1	0.2	-0.3
Reaction Time	0.1	0.1	0.1	-0.3	0.3
Breast Cancer	0.1	0.1	0.3	-0.2	0.5
Age at First Birth	0.1	0.2	0.4	0.6	-0.1
Neuroticism (2016)	0.1	0.1	0.2	0.0	0.4
Blood Red Count	0.1	1.1	1.3	1.0	1.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.1	-0.6
Tanning	0.1	0.9	1.8	-1.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.0	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.0	-0.5
Relative age voice broke	0.1	0.1	0.1	-0.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.3	0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.1	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	-0.4
High blood pressure (mother)	0.1	0.2	0.3	0.6	0.2
Had menopause	0.1	0.1	0.2	0.0	-0.5
Falls in the last year	0.1	0.1	0.2	-0.5	-0.2
Medication: Lansoprazole	0.1	0.1	0.2	0.2	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.1	0.3	0.4
Birth weight	0.1	0.2	0.3	0.5	0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.3	0.6	-0.1
Comparative body size at age 10	0.1	0.2	0.4	0.6	-0.1
Pulse wave peak to peak time	0.1	0.2	0.2	-0.5	0.3
Medication: Omeprazole	0.1	0.1	0.1	-0.3	0.0
Mean time to correctly identify matches	0.1	0.1	0.3	-0.5	-0.1
Asthma (self-reported)	0.1	0.1	0.2	0.3	0.4
Mother’s age at death	0.1	0.1	0.2	0.1	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	-0.3
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.2	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.3	0.5	0.4
Age started oral contraceptive pill	0.1	0.1	0.2	-0.4	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	0.3
Depression (Nagel 2018)	0.0	0.1	0.1	-0.1	-0.3
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.2	0.1
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.2	-0.1
LDL Cholesterol	0.0	0.0	0.0	-0.2	0.0
Blood Platelet Count	0.0	0.0	0.0	0.2	-0.2
Blood White Count	0.0	0.3	0.7	0.0	-0.8
Respiratory disease	0.0	0.1	0.2	0.4	-0.0
Hair Pigment	0.0	0.6	1.0	1.0	0.3
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.2	0.1
Angina	0.0	0.1	0.1	-0.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.1	-0.1
Supplements: Glucosamine	0.0	0.1	0.1	-0.0	0.3
Hair/balding pattern: Pattern 3	0.0	0.1	0.1	0.4	-0.1
Happiness	0.0	0.0	0.0	-0.0	0.1
Noisy workplace	0.0	0.1	0.1	0.1	-0.3
Asthma	0.0	0.0	0.1	-0.1	0.3
Medication: Cholesterol lowering	0.0	0.1	0.1	-0.3	0.2
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.0	-0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.1	0.0
Health satisfaction	0.0	0.0	0.0	0.1	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.1	0.1
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.1	0.4
Angina (self-reported)	0.0	0.0	0.1	0.2	0.2
Had major operations	0.0	0.1	0.1	-0.1	-0.3
Medication: Aspirin	0.0	0.0	0.0	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.2	0.3
Medication: Aspirin	0.0	0.0	0.0	-0.2	-0.1
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.3	-0.1
Financial situation satisfaction	0.0	0.1	0.1	0.3	0.1
Medication: Paracetamol	0.0	0.0	0.1	-0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	0.1	-0.2

Hub : Genes

CACNA1D

Models

Trait associations