TWAS hub - APPL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1080	0.0339	4.0e-06	0.113	NA	0.093	NA	0.114	3.4e-11	NA	2.2e-09	NA	3.1e-11
2	METSIM	Adipose	0.0448	0.0212	4.7e-03	-0.002	0.023	0.004	0.019	-0.001	7.3e-01	0.00021	8.3e-02	7e-04	6.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Platelet Count	33.8	392.3	778.4	2.5	27.9
Myopia	5.1	7.4	14.3	0.7	-3.8
Ulcerative Colitis	4.5	6.6	10.1	-1.8	3.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.4	12.5	-3.5	-3.5
Suffer from ‘nerves’	3.9	6.1	7.5	-2.1	2.7
Forced expiratory volume in 1-second (FEV1)	3.7	12.6	13.2	-3.5	-3.6
Systolic blood pressure, automated reading	3.3	9.5	13.3	3.6	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.0	13.1	-0.9	-3.6
Medication: Seretide 50 evohaler	3.2	3.7	7.2	0.4	2.7
Loneliness, isolation	3.2	4.5	8.8	-0.4	3.0
Prostate Cancer	3.0	4.3	4.9	1.9	-2.2
Diastolic blood pressure, automated reading	2.9	9.1	14.6	1.9	-3.8
Lung FEV1/FVC ratio	2.8	14.2	27.1	-1.1	-5.2
Systolic Blood Pressure	2.7	13.5	14.1	3.6	-3.8
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.1	6.2	-1.4	2.5
LDL Cholesterol	2.6	4.2	5.4	2.3	-1.7
Neuroticism (2016)	2.5	3.6	6.4	-0.8	2.5
Lung FVC	2.5	12.6	23.8	-1.2	-4.9
High blood pressure (mother)	2.5	3.5	6.8	0.5	-2.6
Forced vital capacity (FVC), Best measure	2.5	9.2	9.2	-3.0	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.4	3.2	6.1	-0.5	2.5
Depression (self-reported)	2.4	2.9	5.6	-0.4	2.4
Exposure to tobacco smoke outside home	2.4	3.2	4.4	2.1	-1.4
Blood White Count	2.3	16.7	25.1	-2.9	5.0
Supplements: Vitamin C	2.3	2.8	3.7	-1.4	1.9
Ulcerative Colitis (UC)	2.2	4.1	5.7	-1.6	2.4
Forced vital capacity (FVC)	2.2	8.3	9.5	-3.1	-2.7
Medication: Omeprazole	2.2	2.6	4.0	-1.1	2.0
Depression (Nagel 2018)	2.1	3.1	6.2	-0.1	2.5
Fasting Glucose	2.1	2.5	4.6	-2.1	-0.6
Number of full brothers	2.1	2.7	5.3	-2.3	-0.1
Heart disease (mother)	2.1	2.5	3.3	1.3	-1.8
Alcohol drinker status: Previous	2.1	2.4	3.9	-2.0	0.9
Mother’s age at death	2.0	2.5	3.0	1.7	-1.4
Ever had bowel cancer screening	1.9	2.3	2.3	1.5	-1.5
Breast cancer (self-reported)	1.9	2.3	4.4	0.4	2.1
Major Depression (MDD)	1.8	2.2	2.5	1.6	1.3
Mouth/teeth dental problems	1.8	2.7	5.1	-2.2	-0.6
Medication: Amlodipine	1.8	2.5	4.5	2.1	-0.7
Eye problems/disorders: Cataract	1.8	2.1	2.5	1.3	1.6
Gout (self-reported)	1.7	2.3	4.0	-2.0	-0.8
Neck or shoulder pain in last month	1.7	2.4	3.4	1.2	1.8
Qualifications: nursing, teaching	1.7	2.7	4.2	1.1	-2.0
Wears glasses or contact lenses	1.7	2.0	3.9	-0.3	-2.0
Alzheimer’s Disease (including proxy)	1.6	2.3	4.6	0.1	2.1
Blood Red Count	1.6	15.0	29.5	0.7	-5.4
Heel T-Score	1.6	12.8	25.5	-0.2	-5.0
Multivitamins +/- minerals	1.6	2.1	3.9	-0.6	-2.0
Number of incorrect matches in round	1.6	2.7	5.1	2.3	-0.5
Father’s age at death	1.6	2.1	2.7	-1.2	1.7
Medication: Lansoprazole	1.6	1.8	2.0	-1.3	1.4
Birth weight of first child	1.6	2.9	5.7	-2.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	2.6	-1.1	1.6
Mean Putamen Volume	1.4	1.6	2.3	-1.5	-0.9
Number of treatments/medications taken	1.4	2.5	3.7	-1.1	1.9
Vitamin and mineral supplements	1.4	1.8	1.9	1.4	1.3
Medication: Atenolol	1.4	1.7	3.3	-0.3	1.8
Noisy workplace	1.4	1.7	3.4	1.8	0.1
Average weekly red wine intake	1.4	2.1	3.6	-1.9	-0.7
Illnesses of father: High blood pressure	1.4	1.8	3.0	0.8	-1.7
Age when periods started (menarche)	1.3	3.0	6.1	-2.5	0.2
Hair/balding pattern: Pattern 2	1.3	1.6	2.7	-1.6	0.8
Alcohol intake versus 10 years previously	1.3	1.9	3.7	1.9	0.1
Mouth/teeth dental problems: Dentures	1.3	2.2	4.2	2.0	-0.4
Peak expiratory flow (PEF)	1.3	3.1	4.3	-1.3	-2.1
Health satisfaction	1.3	1.7	3.5	-0.0	1.9
Shortness of breath walking on level ground	1.3	1.5	2.7	0.6	1.6
Eye problems/disorders: None of the above	1.3	1.6	3.1	0.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	3.1	-1.8	-1.5
Medication: Aspirin	1.3	1.7	3.1	0.5	1.8
Commuting to job workplace: Public transport	1.3	1.5	1.7	-1.3	-1.1
Cholesterol lowering medication	1.3	1.9	3.2	0.8	1.8
Depressed Affect (Nagel 2018)	1.2	2.5	4.5	0.7	2.1
Type 2 Diabetes (T2D) (2012)	1.2	1.3	1.7	-1.3	1.0
Trunk fat-free mass	1.2	7.0	11.2	-3.3	-1.7
Falls in the last year	1.2	1.6	2.6	1.6	0.8
Asthma	1.2	2.4	2.4	-1.5	1.6
Trunk predicted mass	1.2	6.6	10.7	-3.3	-1.6
Exposure to tobacco smoke at home	1.2	1.3	2.0	-1.4	0.7
Tense / ‘highly strung’	1.2	1.9	3.5	-0.6	1.9
Blood clot in the leg (DVT)	1.2	1.5	2.7	1.6	0.6
Arm fat-free mass (right)	1.2	6.4	11.2	-3.3	-1.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.5	-1.6	0.7
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	1.7	-1.1	1.3
Pain experienced in last month	1.2	2.1	2.3	-1.4	-1.5
Primary Biliary Cirrhosis	1.1	1.6	3.2	-0.2	-1.8
Hand grip strength (left)	1.1	3.0	5.9	-2.4	-0.2
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.7	-0.7	1.6
Alcohol usually taken with meals	1.1	1.8	3.5	0.3	-1.9
Number of full sisters	1.1	1.3	1.4	1.1	-1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.2	0.5	1.5
Whole body fat-free mass	1.1	6.1	10.4	-3.2	-1.4
Long-standing illness, disability or infirmity	1.1	1.7	3.1	-0.5	1.8
Medication for cholesterol	1.1	1.6	2.6	-0.8	-1.6
Asthma (self-reported)	1.1	2.1	2.2	-1.4	1.5
Whole body water mass	1.1	6.1	10.2	-3.2	-1.4
Financial situation satisfaction	1.1	1.4	2.8	0.2	1.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	1.6	1.3	-1.2
Arm fat-free mass (left)	1.1	5.8	9.5	-3.1	-1.4
Neuroticism (Nagel 2018)	1.0	2.4	4.0	1.0	2.0
Alzheimer’s Disease (in mother)	1.0	1.2	2.4	-0.1	1.5
Reaction Time	1.0	1.9	3.1	-0.9	-1.8
Crohns Disease (2012)	1.0	1.6	2.9	-0.7	-1.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.0	0.5	1.4
Number of live births	1.0	1.4	2.2	-1.5	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	1.7	1.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	1.7	-1.2	1.3
Medication: Allopurinol	1.0	1.3	2.5	-1.6	0.3
Arm predicted mass (right)	1.0	5.3	9.5	-3.1	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.3	1.4	-1.2	1.1
Supplements: Calcium	1.0	1.1	1.4	-1.2	0.9
Arm predicted mass (left)	1.0	5.2	8.6	-2.9	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.2	2.3	-1.5	1.5
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	1.4	0.2
Hand grip strength (right)	0.9	2.5	2.8	-1.5	-1.7
Sitting height	0.9	6.3	9.3	-3.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.5	1.2	0.7
Illnesses of mother	0.9	1.2	2.2	0.4	1.5
Length of working week for main job	0.9	1.0	1.9	1.4	-0.1
Medication: Paracetamol	0.9	1.5	2.9	-0.3	1.7
Birth weight	0.9	2.0	3.9	-0.1	-2.0
Wheeze or whistling in the chest in last year	0.9	1.6	3.1	-0.0	1.8
Illnesses of siblings: Diabetes	0.9	1.1	2.1	-0.2	1.4
Leg fat-free mass (right)	0.9	4.6	8.5	-2.9	-0.9
Friendships satisfaction	0.9	1.1	1.9	1.4	-0.4
Back pain experienced in last month	0.9	1.3	1.7	1.0	1.3
Leg predicted mass (right)	0.9	5.0	9.3	-3.0	-0.8
Basal metabolic rate	0.9	5.2	8.9	-3.0	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.0	1.4	0.5
Ovarian Cancer	0.8	1.1	2.1	-0.3	1.4
HbA1C	0.8	0.9	1.6	-1.2	0.5
Leg fat-free mass (left)	0.8	4.0	7.1	-2.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.5	-0.4	-1.9
Qualifications: CSEs or equivalent	0.8	1.1	2.1	-0.0	1.5
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.5	-0.6	1.2
Leg predicted mass (left)	0.8	4.0	7.2	-2.7	-0.9
Fluid intelligence score	0.8	1.7	1.8	-1.3	1.2
Prospective memory result	0.8	1.0	1.2	1.1	-0.9
Standing height	0.8	7.5	14.2	-3.8	-0.9
Headache pain in last month	0.8	1.4	2.6	-0.5	1.6
Qualifications: College or University degree	0.8	2.6	4.5	-0.8	-2.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.9	0.3	1.4
Emphysema/chronic bronchitis	0.8	1.0	1.6	0.6	1.3
Medication: Ibuprofen	0.8	1.0	1.7	1.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.0	0.1	1.4
Overall health rating	0.8	1.8	2.4	1.1	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.8	-1.3	0.2
Mood swings	0.8	1.5	1.8	1.1	1.3
Number of self-reported non-cancer illnesses	0.8	1.3	1.5	-1.2	1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.9	-1.4	-0.1
Medication: Lisinopril	0.8	1.1	2.1	1.4	-0.2
Number of operations (self-reported)	0.8	1.2	2.4	-0.3	-1.5
Bipolar Disorder (2018)	0.7	1.0	1.8	-1.3	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.7	1.9	-1.4	-1.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.5	-1.3	1.6
Bipolar Disorder (2011)	0.7	0.7	1.3	-0.2	1.2
Lupus	0.7	1.1	1.6	0.7	1.3
Angina	0.7	0.9	1.5	-1.2	-0.6
Diabetes (father)	0.7	0.9	1.1	0.8	1.1
Current tobacco smoking	0.7	1.1	1.2	1.0	1.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.4	-0.8	-1.5
Time employed in main current job	0.7	0.8	1.1	1.1	0.7
Glaucoma (self-reported)	0.7	0.9	1.6	-1.3	-0.4
Pulse rate, automated reading	0.7	2.3	4.4	0.4	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	0.9	1.0	0.9
Medication: Aspirin	0.7	1.0	1.7	0.6	1.3
Illnesses of father: Heart disease	0.7	1.0	2.0	0.1	-1.4
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.7	-0.3	-1.3
Smoking status: Current	0.7	1.2	1.8	0.7	1.4
Medication: Bendroflumethiazide	0.7	1.0	2.0	1.4	-0.3
Medication: Paracetamol	0.7	1.0	1.9	-0.3	1.4
Smoking Status	0.6	1.5	2.4	0.8	1.6
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.1	-1.1	1.0
Sensitivity / hurt feelings	0.6	1.1	1.8	1.4	0.6
Qualifications: None of the above	0.6	1.3	1.9	0.8	1.4
Financial difficulties in last 2 years	0.6	0.8	1.6	-0.2	1.3
Impedance of arm (right)	0.6	2.8	3.7	1.9	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.0	-0.2	1.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.2	1.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.0	0.1	1.4
High blood pressure (siblings)	0.6	0.9	1.6	0.4	-1.2
Medication for pain relief, constipation, heartburn	0.6	1.1	2.1	-0.2	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-0.2	-1.2
Osteoarthritis (self-reported)	0.6	0.7	1.4	0.1	1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.6	-1.3	0.2
Miserableness	0.6	1.0	1.6	-0.6	1.3
Medication: Blood pressure	0.6	1.1	2.1	0.4	1.5
Schizophrenia (2014)	0.5	1.0	1.7	-1.3	-0.6
Height	0.5	9.8	19.6	-4.4	0.0
Chronotype (morning person)	0.5	1.1	2.1	0.2	-1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.3	1.8	-0.9	-1.3
Weight	0.5	2.4	4.8	-2.2	-0.1
Happiness	0.5	0.6	1.1	0.3	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-1.5	-0.3
Medication: Cholesterol lowering	0.5	0.7	0.9	-0.8	-0.9
Breastfed as a baby	0.5	0.6	1.1	-0.4	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	0.5	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.3	1.0
Angina (self-reported)	0.5	0.7	1.3	-1.1	-0.4
Had major operations	0.5	0.6	0.7	0.7	-0.8
Family relationship satisfaction	0.5	0.6	1.1	-0.2	1.0
Unable to work because of sickness or disability	0.5	0.6	1.2	-0.3	1.1
Heart disease (siblings)	0.5	0.6	1.2	1.1	0.1
Schizophrenia (2018)	0.4	0.9	1.3	-0.7	-1.1
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	0.5
Crohns Disease (2017)	0.4	0.9	1.8	0.0	-1.4
Cardiovascular Disease	0.4	1.2	2.2	1.5	-0.5
Respiratory disease	0.4	0.8	1.0	-0.7	1.0
Relative age of first facial hair	0.4	0.9	1.1	-0.8	1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.8	-0.9	0.3
Medication for hormone replacement therapy	0.4	0.4	0.8	0.9	-0.2
Impedance of leg (right)	0.4	1.9	2.6	1.6	1.1
Taking other prescription medications	0.4	0.6	1.0	-0.5	1.0
Impedance of leg (left)	0.4	1.8	2.2	1.2	1.5
Waist circumference	0.4	1.3	2.3	-1.5	0.6
Had other major operations	0.4	0.5	0.6	-0.5	-0.8
Hip circumference	0.4	1.7	2.1	-1.4	1.1
Impedance of arm (left)	0.4	1.9	3.0	0.9	1.7
Hair/balding pattern: Pattern 4	0.4	1.0	1.2	0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	0.9	-0.9	-0.7
Arm fat mass (left)	0.4	1.8	3.3	-1.8	0.6
Ever taken oral contraceptive pill	0.4	0.5	0.6	0.6	-0.7
Ever depressed for a whole week	0.4	0.5	0.7	0.9	-0.5
Basal cell carcinoma (self-reported)	0.4	0.4	0.6	-0.8	-0.5
Impedance of whole body	0.4	2.3	2.7	1.4	1.6
Irritable Bowel Disease (IBD)	0.3	0.7	0.7	-0.9	0.9
HDL Cholesterol	0.3	0.5	1.0	0.1	1.0
Neuroticism	0.3	0.8	0.9	0.8	0.9
Supplements: Zinc	0.3	0.3	0.5	-0.4	0.7
Severe depression (siblings)	0.3	0.3	0.6	0.2	-0.8
Trunk fat percentage	0.3	1.1	2.0	-0.4	1.4
Hearing difficulty/problems with background noise	0.3	0.5	1.0	-0.3	1.0
Pain all over the body in last month	0.3	0.4	0.4	0.5	-0.7
Medication: Simvastatin	0.3	0.5	0.8	-0.3	0.9
Pulse rate	0.3	0.5	0.9	0.1	1.0
Lung cancer (father)	0.3	0.3	0.3	-0.5	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	-0.6	-0.5
Comparative body size at age 10	0.3	0.9	1.4	0.7	-1.2
Worry too long after embarrassment	0.3	0.6	0.9	-0.5	0.9
Alcohol intake frequency.	0.3	0.8	1.5	-0.1	1.2
Knee pain experienced in last month	0.3	0.5	0.9	0.2	0.9
Diabetes diagnosed by doctor	0.3	0.4	0.5	-0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.3	0.8
Guilty feelings	0.3	0.5	0.7	-0.5	0.8
Breast Cancer	0.2	0.4	0.4	0.6	-0.6
Age at First Birth	0.2	0.3	0.4	0.5	0.6
Rheumatoid Arthritis	0.2	0.2	0.5	0.7	-0.2
Triglycerides	0.2	0.4	0.5	0.5	-0.7
Blood Eosinophil Count	0.2	1.9	3.8	0.2	1.9
BMI	0.2	1.1	2.0	-1.4	0.5
Allergy or Eczema	0.2	0.4	0.7	-0.4	-0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	0.4	0.5
Medication: Metformin	0.2	0.3	0.6	-0.8	-0.2
Diabetes (mother)	0.2	0.3	0.3	-0.5	-0.5
Average weekly fortified wine intake	0.2	0.2	0.3	0.4	-0.6
High blood pressure	0.2	0.4	0.6	0.8	0.5
Trunk fat mass	0.2	0.9	1.3	-1.1	0.8
Nervous feelings	0.2	0.4	0.7	0.2	0.8
Had menopause	0.2	0.3	0.4	0.6	0.4
Diabetes (self-reported)	0.2	0.4	0.5	-0.5	0.7
Arm fat percentage (right)	0.2	0.6	1.3	-0.0	1.1
Arm fat mass (right)	0.2	1.0	1.9	-1.4	0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.8	0.2
Body fat percentage	0.2	0.9	1.7	-0.1	1.3
Leg fat percentage (right)	0.2	0.7	0.8	0.8	0.9
Number of children fathered	0.2	0.2	0.4	-0.6	-0.1
Medication: Blood pressure	0.2	0.4	0.6	0.3	-0.8
Mean time to correctly identify matches	0.2	0.4	0.8	0.0	-0.9
Whole body fat mass	0.2	0.8	1.1	-1.1	0.7
Comparative height size at age 10	0.2	1.4	1.5	-1.1	-1.2
Hypertension (Self-reported)	0.2	0.5	0.5	0.7	0.7
Arm fat percentage (left)	0.2	0.9	1.5	-0.5	1.2
Mineral and other dietary supplements	0.2	0.3	0.6	0.0	0.8
Osteoporosis (self-reported)	0.2	0.2	0.4	0.6	-0.1
Hearing aid user	0.2	0.2	0.4	0.3	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.2	0.6
High cholesterol (Self-reported)	0.2	0.4	0.6	-0.7	0.4
Ever smoked	0.2	0.3	0.4	-0.4	-0.6
Leg fat percentage (left)	0.2	0.6	1.0	0.5	1.0
Age started oral contraceptive pill	0.2	0.2	0.3	0.6	0.3
Commuting to job workplace: Cycle	0.2	0.3	0.3	0.5	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.6	-0.2
Worry (Nagel 2018)	0.1	0.2	0.4	-0.0	0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.2	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.4	-0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.3	-1.1	0.0
Average weekly spirits intake	0.1	0.1	0.2	0.1	-0.5
Medication: Co-codamol	0.1	0.1	0.2	0.2	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	0.0
Maternal smoking around birth	0.1	0.2	0.3	0.3	-0.5
Fed-up feelings	0.1	0.1	0.2	0.2	0.4
Relative age voice broke	0.1	0.1	0.2	0.1	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.5	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.5	0.1
Body mass index (BMI)	0.1	0.3	0.5	-0.7	0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.4	-0.3
Heart attack	0.1	0.1	0.1	-0.4	-0.1
Allergy	0.1	0.2	0.4	0.3	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.4	0.1
Illnesses of siblings	0.1	0.1	0.2	-0.5	-0.0
Neuroticism score	0.1	0.1	0.3	-0.0	0.5
Worrier / anxious feelings	0.1	0.1	0.2	0.4	-0.3
Pulse wave reflection index	0.1	0.2	0.3	0.3	0.5
Loud music exposure frequency	0.1	0.1	0.2	0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.3	-0.4
Age at first live birth	0.1	0.1	0.3	-0.0	0.5
Pulse wave peak to peak time	0.1	0.1	0.1	0.3	0.4
Leg fat mass (right)	0.1	0.3	0.3	-0.5	0.6
Age at last live birth	0.1	0.1	0.1	-0.3	0.3
Leg pain on walking	0.1	0.2	0.3	0.2	0.5
Medication: Gliclazide	0.1	0.2	0.3	-0.0	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	0.6	-0.0
Medication: Atorvastatin	0.1	0.2	0.3	0.2	-0.5
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.3	0.6	0.2
Risk taking	0.1	0.1	0.2	-0.2	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.6	0.0
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.6	-0.1
Leg fat mass (left)	0.1	0.4	0.5	-0.7	0.5
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	-0.0	0.3
Hypothyroidism (self reported)	0.0	0.1	0.1	0.3	0.1
Hair Pigment	0.0	0.5	0.6	-0.5	0.8
Tanning	0.0	0.3	0.6	-0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.1	-0.0
Pack years adult smoking proportion	0.0	0.0	0.0	-0.2	-0.1
Serious illness, injury or assault to yourself	0.0	0.1	0.1	-0.3	-0.0
Supplements: Glucosamine	0.0	0.0	0.0	-0.1	-0.0
Medication: Levothyroxine sodium	0.0	0.1	0.2	0.0	-0.4
Past tobacco smoking	0.0	0.0	0.0	-0.1	0.1
Medication: Ramipril	0.0	0.0	0.0	0.2	-0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	-0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.1	0.0
Migraine (self-reported)	0.0	0.1	0.1	-0.3	-0.1
Chest pain or discomfort	0.0	0.1	0.1	0.3	0.3
Smoking status: Previous	0.0	0.0	0.0	0.1	-0.2
Commuting to job workplace: Walk	0.0	0.1	0.1	-0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.2	0.1
Irritability	0.0	0.1	0.2	0.4	0.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.5	-0.1
Pack years of smoking	0.0	0.0	0.0	0.2	0.2

Hub : Genes

APPL1

Models

Trait associations