[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:93,348,659-95,856,679

Best TWAS P=2.66e-42 · Best GWAS P=4.6e-49 conditioned to 6.25e-12

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Colon Sigmoid	SPATA9	0.21	0.12	lasso	3	0.06	5.2e-03	12.66	13.6	2.7e-42	0.75	0.02	0.92	TRUE
12	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPATA9	0.07	0.02	blup	54	0.06	1.6e-03	9.02	9.2	2.8e-20	0.51	0.04	0.15	FALSE
11	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPATA9	0.03	0.01	blup	54	0.02	4.0e-03	-4.40	7.7	1.2e-14	0.43	0.04	0.06	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPATA9	0.04	0.04	blup	54	0.03	6.0e-04	-4.40	7.5	7.5e-14	0.45	0.39	0.06	FALSE
5	GTEx	Esophagus Gastroesophageal Junction	ARSK	0.22	0.06	enet	12	0.08	8.9e-04	1.60	-7.4	1.5e-13	-0.28	0.23	0.09	FALSE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	SPATA9	0.07	0.03	lasso	1	0.04	3.4e-03	-6.77	6.8	1.3e-11	0.52	0.06	0.15	FALSE
7	GTEx	Testis	RFESD	0.16	0.03	lasso	4	0.02	5.5e-02	-4.24	6.2	4.5e-10	0.28	0.08	0.08	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MCTP1	0.07	0.00	bslmm	616	0.01	1.9e-02	1.69	-6.2	5.9e-10	-0.12	0.10	0.06	FALSE
3	GTEx	Adipose Visceral Omentum	SPATA9	0.18	0.00	lasso	7	0.01	1.6e-01	-4.40	6.1	1.1e-09	0.30	0.08	0.04	FALSE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPATA9	0.10	0.13	lasso	7	0.12	6.4e-14	-4.24	5.9	3.5e-09	0.37	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GLRX	0.05	0.00	bslmm	388	0.02	2.1e-03	0.39	-5.9	3.9e-09	-0.24	0.04	0.03	FALSE
6	GTEx	Nerve Tibial	ARSK	0.24	0.17	lasso	6	0.14	2.5e-10	-4.40	-5.2	1.8e-07	-0.29	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Thyroid Carcinoma	SPATA9	0.09	0.11	lasso	4	0.10	4.9e-10	-4.24	5.2	2.0e-07	0.28	1.00	0.00	FALSE