[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:93,348,659-95,856,679

Best TWAS P=2.66e-42 · Best GWAS P=4.6e-49 conditioned to 6.25e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GLRX 0.05 0.00 bslmm 388 0.02 2.1e-03 0.39 -5.9 3.9e-09 -0.24 0.04 0.03 FALSE
2 CommonMind Brain Pre-frontal Cortex MCTP1 0.07 0.00 bslmm 616 0.01 1.9e-02 1.69 -6.2 5.9e-10 -0.12 0.10 0.06 FALSE
3 GTEx Adipose Visceral Omentum SPATA9 0.18 0.00 lasso 7 0.01 1.6e-01 -4.40 6.1 1.1e-09 0.30 0.08 0.04 FALSE
4 GTEx Colon Sigmoid SPATA9 0.21 0.12 lasso 3 0.06 5.2e-03 12.66 13.6 2.7e-42 0.75 0.02 0.92 TRUE
5 GTEx Esophagus Gastroesophageal Junction ARSK 0.22 0.06 enet 12 0.08 8.9e-04 1.60 -7.4 1.5e-13 -0.28 0.23 0.09 FALSE
6 GTEx Nerve Tibial ARSK 0.24 0.17 lasso 6 0.14 2.5e-10 -4.40 -5.2 1.8e-07 -0.29 1.00 0.00 FALSE
7 GTEx Testis RFESD 0.16 0.03 lasso 4 0.02 5.5e-02 -4.24 6.2 4.5e-10 0.28 0.08 0.08 FALSE
8 The Cancer Genome Atlas Colon Adenocarcinoma SPATA9 0.07 0.03 lasso 1 0.04 3.4e-03 -6.77 6.8 1.3e-11 0.52 0.06 0.15 FALSE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SPATA9 0.04 0.04 blup 54 0.03 6.0e-04 -4.40 7.5 7.5e-14 0.45 0.39 0.06 FALSE
10 The Cancer Genome Atlas Brain Lower Grade Glioma SPATA9 0.10 0.13 lasso 7 0.12 6.4e-14 -4.24 5.9 3.5e-09 0.37 1.00 0.00 FALSE
11 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SPATA9 0.03 0.01 blup 54 0.02 4.0e-03 -4.40 7.7 1.2e-14 0.43 0.04 0.06 FALSE
12 The Cancer Genome Atlas Pancreatic Adenocarcinoma SPATA9 0.07 0.02 blup 54 0.06 1.6e-03 9.02 9.2 2.8e-20 0.51 0.04 0.15 FALSE
13 The Cancer Genome Atlas Thyroid Carcinoma SPATA9 0.09 0.11 lasso 4 0.10 4.9e-10 -4.24 5.2 2.0e-07 0.28 1.00 0.00 FALSE