Hub : Genes

MCTP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0280	0.0036	-0.002	0.008	0.005	0.01	0.000	0.80	0.03100	0.076	0.019	0.29
2	GTEx	Brain Cerebellum	0.2690	0.0920	0.0057	-0.010	NA	0.006	NA	0.003	0.87	NA	0.210	NA	0.26
3	TCGA	Breast Invasive Carcinoma	0.0305	0.0138	0.0038	-0.001	0.017	0.005	NA	-0.001	0.77	0.00013	0.030	NA	0.72
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1720	0.0690	0.0082	-0.003	-0.002	-0.004	NA	-0.005	0.54	0.41000	0.740	NA	0.86

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.8	2.8	6.5	-2.1	-0.4	0.1	2.5
Bipolar Disorder or Schizophrenia	1.3	3.1	6.8	-2.6	-0.8	-0.6	2.2
Depressed Affect (Nagel 2018)	1.5	3.1	7.3	1.0	-2.0	-0.5	2.7
Depression (Nagel 2018)	0.2	0.3	0.9	0.1	0.1	1.0	0.2
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.5	-1.6	-1.0	-0.8	-0.1
Neuroticism (Nagel 2018)	0.7	1.6	2.6	0.6	-1.6	1.1	1.5
Schizophrenia (2018)	0.5	1.1	2.5	-1.6	-0.7	-0.9	0.8
Schizophrenia vs Biploar Disorder	1.5	1.9	4.4	2.1	1.7	0.4	-0.6
Worry (Nagel 2018)	0.4	0.8	2.6	0.4	-0.1	1.6	-0.6
Alzheimer’s Disease (in mother)	0.8	0.9	1.7	-0.1	-1.3	-1.0	0.9
Alzheimer’s Disease (in father)	0.8	0.9	1.4	-1.2	0.8	0.8	-0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	-0.6	-0.9	-0.4	-0.0
Crohns Disease (2017)	0.6	1.4	4.4	1.1	-0.2	0.1	2.1
Irritable Bowel Disease (IBD)	0.5	1.2	3.6	0.4	0.8	-0.7	1.9
Ulcerative Colitis (UC)	0.5	0.9	1.1	-0.5	1.0	-1.1	1.1
Major Depression (MDD)	0.3	0.3	0.9	-0.0	0.6	0.4	-0.9
Reaction Time	1.5	2.9	5.7	1.4	-1.8	2.4	0.6
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.0	-1.7	-1.7	-1.4	-0.5
Breast Cancer	0.7	1.7	4.2	-1.3	2.0	0.5	-0.8
Ovarian Cancer	0.7	1.0	2.5	-0.9	-0.5	0.5	1.6
Prostate Cancer	1.7	2.4	4.9	-0.8	0.2	-2.2	-2.0
Age at First Birth	0.7	1.1	1.5	-1.2	1.0	1.2	-0.6
Bipolar Disorder (2011)	5.3	5.1	10.1	-3.2	-1.2	-0.1	3.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.7	0.1	-0.8	0.1
Coronary Artery Disease (CAD)	0.8	0.9	2.7	1.6	0.2	-1.0	-0.1
Crohns Disease (2012)	0.4	0.6	2.2	0.1	-0.2	-0.3	1.5
Mean Putamen Volume	1.2	1.3	2.8	-1.7	0.3	1.5	-0.5
Fasting Glucose	1.4	1.7	6.0	-0.6	2.5	0.6	-0.0
HbA1C	0.3	0.3	0.6	0.2	0.3	0.8	0.7
HDL Cholesterol	0.5	0.8	2.0	-0.7	-1.4	-0.6	-0.6
LDL Cholesterol	0.5	0.7	1.7	1.3	-0.6	0.3	-0.9
Lupus	0.8	1.1	2.2	-0.3	1.4	1.5	-0.5
Neuroticism (2016)	0.8	1.1	3.3	0.7	0.8	1.8	0.0
Primary Biliary Cirrhosis	0.3	0.4	1.3	0.3	1.1	0.2	-0.4
Rheumatoid Arthritis	1.2	1.7	3.6	-1.3	0.4	1.2	-1.9
Schizophrenia (2014)	0.5	1.0	2.4	-0.7	-0.5	-1.0	1.6
Triglycerides	0.3	0.5	1.9	0.3	-1.4	-0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.1	0.4	0.2	1.1	-0.4
Ulcerative Colitis	0.3	0.5	1.1	0.0	1.1	-0.4	0.8
Blood Eosinophil Count	0.1	0.9	1.7	-0.8	1.3	0.8	-0.8
Blood Platelet Count	0.1	1.4	2.8	-1.7	1.4	-0.3	-0.9
Blood Red Count	0.1	0.8	1.9	0.3	1.4	1.0	-0.4
Blood White Count	0.2	1.6	3.8	0.3	2.0	1.2	-0.9
Heel T-Score	0.1	0.5	0.6	-0.6	-0.8	-0.7	-0.7
BMI	0.7	3.8	8.7	-0.7	3.0	-1.3	-2.0
Height	0.0	0.7	2.7	0.0	0.2	0.2	-1.7
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-0.0	-0.8	-1.1	-0.1
Systolic Blood Pressure	0.4	1.8	5.6	-0.0	1.0	0.8	-2.4
Smoking Status	0.5	1.2	2.5	-0.4	1.5	-0.2	-1.6
Allergy or Eczema	0.4	1.0	3.5	-1.9	-0.2	0.1	0.7
Cardiovascular Disease	0.3	0.8	2.6	0.1	0.4	-0.7	-1.6
Hypothyroidism (self reported)	0.7	1.6	5.0	-2.2	-0.7	-0.9	-0.1
Respiratory disease	0.3	0.7	1.7	0.0	1.3	-0.4	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	-0.7	1.1	-0.5	0.5
Lung FEV1/FVC ratio	2.0	10.1	38.3	-6.2	-0.5	0.6	-1.2
Lung FVC	0.7	3.8	9.3	3.1	1.6	0.5	1.7
Neuroticism	0.3	0.7	1.2	0.3	-0.4	1.1	1.1
Chronotype (morning person)	1.3	3.1	10.2	3.2	-0.4	0.2	1.4
Hair Pigment	0.0	0.9	2.0	-0.8	-1.4	0.1	-0.9
Tanning	0.2	2.4	3.9	0.3	-1.6	-2.0	1.7
Hand grip strength (left)	0.7	2.0	4.7	-1.6	0.7	-2.2	-0.3
Number of treatments/medications taken	0.4	0.8	1.9	-1.4	-0.4	0.3	-1.0
Average weekly spirits intake	0.5	0.7	1.5	-0.3	1.0	-0.3	1.2
Sensitivity / hurt feelings	0.7	1.2	2.2	1.5	0.4	1.5	-0.6
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.4	1.5	0.4	1.4	0.9
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-0.2	0.9	0.7	-1.4
Relative age of first facial hair	0.5	1.1	1.9	-1.4	0.8	-0.3	-1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.7	0.2	-0.9	0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.1	0.3	-1.1	-0.1	0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-1.0	-0.4	-0.1	-1.0
Systolic blood pressure, automated reading	1.0	3.0	7.8	0.7	2.8	0.4	-1.9
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.1	0.0	0.8	1.1	-0.7
Angina	0.9	1.2	2.3	-1.5	1.3	0.6	-0.7
Medication for hormone replacement therapy	3.6	4.1	11.1	-1.2	-3.3	-1.7	0.9
Vitamin and mineral supplements	0.9	1.2	3.0	1.3	-0.0	-1.7	-0.1
Supplements: Zinc	0.1	0.1	0.1	0.4	0.2	-0.2	-0.4
Medication: Co-codamol	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.2
Medication: Metformin	0.6	0.8	1.9	-1.4	1.2	0.3	0.1
Diabetes (father)	0.4	0.5	1.0	-1.0	0.5	-0.6	-0.7
Diabetes (mother)	1.0	1.3	3.1	-1.4	1.8	-0.3	0.4
Severe depression (siblings)	0.4	0.4	0.6	0.7	-0.8	0.0	0.8
Pack years adult smoking proportion	0.4	0.6	1.9	-1.4	0.6	-0.6	0.1
Impedance of leg (right)	0.4	1.9	7.4	-0.2	-2.7	0.3	0.5
Leg fat-free mass (left)	0.3	1.4	4.2	-0.7	2.0	0.1	-1.0
Trunk fat percentage	0.3	1.4	2.0	-1.4	1.3	-0.2	-1.3
Hand grip strength (right)	0.7	2.0	4.5	-1.8	0.5	-2.1	-0.2
Townsend deprivation index at recruitment	0.2	0.2	0.8	-0.1	0.9	-0.1	-0.2
Current tobacco smoking	1.5	2.4	3.7	-1.9	1.7	1.6	-0.7
Average weekly fortified wine intake	1.0	1.1	2.4	-0.5	1.2	0.7	-1.5
Maternal smoking around birth	0.2	0.3	1.0	-0.1	-0.4	0.1	-1.0
Fed-up feelings	1.0	1.8	3.6	1.9	-0.9	0.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.8	1.4	0.4	1.2	1.3
Relative age voice broke	1.0	1.5	4.4	-0.3	1.1	0.3	-2.1
Taking other prescription medications	0.3	0.5	1.5	0.4	0.6	1.2	-0.1
Age when periods started (menarche)	1.2	2.8	9.2	3.0	1.4	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.0	1.2	-1.4	0.9	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.3	0.7	-0.5	-0.6
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	5.7	2.4	1.7	-1.3	-0.9
Qualifications: CSEs or equivalent	1.7	2.3	7.3	0.1	-0.1	2.7	-1.3
Serious illness, injury or assault to yourself	2.1	2.5	4.9	-2.2	1.1	-1.1	-1.6
High blood pressure	0.2	0.6	1.4	-0.6	-0.8	-1.2	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.5	-1.9	0.1	-0.6	0.7
Multivitamins +/- minerals	1.4	1.7	2.7	-1.6	0.7	1.6	-1.1
Stomach or abdominal pain in last month	0.7	0.8	1.7	-1.3	-0.3	-0.1	-1.2
Supplements: Glucosamine	0.8	1.0	2.5	-0.8	-1.6	0.5	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.4	-0.6	0.8	-1.2	1.2
Medication: Atenolol	0.5	0.6	1.2	-1.1	-0.2	0.9	-0.6
Medication: Levothyroxine sodium	0.3	0.5	1.3	-1.1	0.8	-0.4	0.4
Sitting height	0.2	1.5	2.9	1.1	1.7	1.0	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.7	0.7	-0.6	1.3	0.3
High blood pressure (mother)	0.9	1.3	3.7	-0.9	0.5	1.9	-0.5
Body mass index (BMI)	0.7	2.8	8.8	-0.8	3.0	-1.0	-0.9
Impedance of leg (left)	0.3	1.4	5.3	-0.2	-2.3	0.2	0.1
Leg predicted mass (left)	0.3	1.4	4.1	-0.7	2.0	0.1	-1.0
Trunk fat mass	0.4	1.6	3.1	-1.5	1.8	-0.2	-0.9
Waist circumference	0.3	1.3	3.5	-0.8	1.9	-0.5	-0.9
Number of incorrect matches in round	0.4	0.7	0.8	0.7	-0.9	0.9	0.9
Past tobacco smoking	0.2	0.4	0.8	-0.0	-0.9	0.8	0.1
Alcohol usually taken with meals	0.9	1.5	3.0	-1.7	-0.4	0.9	1.4
Nervous feelings	1.1	2.0	4.6	1.2	0.9	2.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.6	1.9	-0.9	1.3	1.6
Hearing difficulty/problems with background noise	0.9	1.5	5.4	0.6	-0.3	2.3	0.2
Hair/balding pattern: Pattern 2	0.8	1.0	1.8	0.7	1.3	0.1	-1.3
Had menopause	0.1	0.2	0.4	0.3	0.4	0.6	0.2
Had other major operations	0.1	0.1	0.4	0.1	-0.1	-0.2	0.6
Forced vital capacity (FVC)	0.4	1.7	3.4	1.8	1.7	0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	0.5	0.1	-1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.9	0.3	0.8	-1.7	-0.0
Qualifications: None of the above	0.5	1.0	2.9	1.7	1.1	-0.3	-0.1
Financial difficulties in last 2 years	1.0	1.3	3.8	-0.8	1.9	0.2	-0.9
Mouth/teeth dental problems	1.0	1.5	5.6	0.4	-0.2	-2.4	-0.4
Heart attack	1.4	1.8	4.0	1.6	-2.0	-0.6	0.7
Allergy	0.1	0.2	0.5	0.7	-0.4	-0.3	-0.2
Pain all over the body in last month	2.4	2.5	6.1	1.3	2.5	-0.3	-1.5
Diabetes (self-reported)	0.3	0.5	1.1	-0.2	1.0	0.5	0.8
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.0	0.1	0.5	0.1
Medication: Ramipril	0.9	1.2	2.6	-1.6	-0.6	1.0	-0.9
Medication: Simvastatin	0.4	0.6	1.4	0.2	0.4	1.2	-0.9
Fluid intelligence score	0.3	0.5	1.2	-0.1	-0.4	-1.1	-0.8
Illnesses of siblings	1.3	1.8	4.7	-0.8	-2.2	-1.1	0.8
Neuroticism score	0.4	0.9	2.2	1.5	-0.0	1.2	0.4
Weight	0.4	2.2	6.5	-0.9	2.5	-0.3	-1.1
Impedance of arm (right)	0.7	3.4	9.6	-0.8	-3.1	1.8	-0.4
Arm fat percentage (right)	0.4	1.5	2.6	-1.6	1.6	-0.2	-0.9
Trunk fat-free mass	0.3	1.5	6.1	-0.0	2.5	-0.1	0.2
Hip circumference	0.4	1.8	4.9	-0.7	2.2	0.2	-1.3
Time employed in main current job	0.5	0.6	1.6	0.5	1.3	0.5	-0.4
Alcohol intake versus 10 years previously	0.6	0.8	2.5	0.3	-1.6	-0.7	0.6
Father’s age at death	0.4	0.6	2.0	-0.1	-0.5	-1.4	0.0
Worrier / anxious feelings	0.2	0.4	1.1	-0.0	-1.1	0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.1	1.5	2.0	0.8	-1.6
Falls in the last year	1.4	1.9	3.8	-0.6	1.4	1.3	-2.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.3	-0.2	-0.0	0.1	1.5
Number of live births	0.6	0.9	1.7	0.6	1.3	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	0.1	1.2	0.9	0.3
Pulse rate	1.1	1.8	3.2	-1.8	-0.0	1.8	-0.9
Happiness	1.8	2.2	6.3	-0.8	-2.5	-0.9	0.9
Noisy workplace	0.4	0.5	1.2	1.1	-0.4	0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.8	-1.0	-0.3	-1.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.6	0.8	-0.6	-0.7	0.3
Mouth/teeth dental problems: Dentures	1.0	1.7	5.4	0.7	0.6	2.3	0.7
Asthma	0.1	0.2	0.3	0.1	0.6	0.5	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.9	-1.7	-1.6	-0.2	-0.5
Medication: Cholesterol lowering	0.7	1.0	2.0	-1.4	0.5	1.0	-0.9
Depression (self-reported)	1.1	1.3	1.9	-1.4	1.0	1.1	1.1
Medication: Lansoprazole	0.8	0.9	2.0	-1.1	-0.6	-0.3	1.4
Prospective memory result	0.1	0.1	0.1	0.3	0.3	0.3	-0.2
Lung cancer (father)	0.8	0.9	2.7	0.5	0.8	-0.0	-1.7
Illnesses of mother	1.3	1.6	2.4	0.9	-1.1	-1.5	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.6	0.7	0.3	1.2	-0.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.0	0.1	1.1	-0.6
Impedance of arm (left)	0.9	4.1	10.2	-0.6	-3.2	2.2	-1.0
Arm fat mass (right)	0.5	2.2	5.7	-1.3	2.4	-0.7	-1.1
Trunk predicted mass	0.3	1.6	6.2	-0.1	2.5	-0.1	0.2
Standing height	0.1	0.7	2.0	-0.1	-0.4	1.4	-0.9
Length of working week for main job	0.8	0.9	2.8	0.1	-1.7	-0.7	-0.6
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.1	0.4	0.7	-0.5
Breastfed as a baby	1.9	2.3	6.2	-0.3	-0.9	-1.5	2.5
Tense / ‘highly strung’	1.1	1.8	4.3	0.7	1.0	2.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.4	-0.9	0.8	-0.5	-1.5
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	-1.4	-1.0	-0.6	0.6
Birth weight of first child	0.3	0.5	0.9	0.4	-0.6	0.7	0.9
Peak expiratory flow (PEF)	0.6	1.4	4.4	-0.6	2.1	-0.5	0.7
Pulse wave reflection index	1.6	2.0	4.0	1.5	1.4	0.2	-2.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	1.1	0.3	0.1	-0.2
Loud music exposure frequency	0.5	0.5	0.9	-0.5	-0.9	1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.3	-0.8	1.1	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.5	0.6	0.3	0.7
Blood clot in the leg (DVT)	0.4	0.5	1.0	0.6	-0.6	1.0	0.4
Medication: Paracetamol	0.0	0.0	0.1	0.1	0.3	-0.2	0.0
Headache pain in last month	1.8	3.0	5.1	-1.5	-2.1	2.3	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	1.7	-0.0	-0.8	0.6
Glaucoma (self-reported)	1.5	1.7	4.8	-1.2	2.2	-0.1	-0.8
Gout (self-reported)	0.4	0.5	1.8	1.3	0.2	0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.9	-0.6	-0.2	-0.9	0.3
Medication: Amlodipine	1.1	1.6	4.4	-0.5	-0.7	-1.1	-2.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.5	0.9	-1.0	-1.2	-0.2
Birth weight	0.6	1.2	2.5	1.3	1.6	0.8	-0.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	5.3	0.9	1.2	2.3	-0.2
High blood pressure (siblings)	1.3	1.9	3.3	-1.2	1.5	1.8	-0.6
Forced vital capacity (FVC), Best measure	0.4	1.4	4.0	2.0	0.7	1.0	0.2
Body fat percentage	0.4	1.4	3.2	-1.8	1.3	-0.4	-0.8
Leg fat percentage (right)	0.5	1.8	3.9	-2.0	1.5	-0.8	-0.6
Arm fat-free mass (right)	0.4	2.2	8.4	0.2	2.9	-0.7	-0.1
Exposure to tobacco smoke outside home	0.7	1.0	1.6	1.0	1.2	-0.2	-1.2
Comparative body size at age 10	0.7	1.9	4.8	-1.0	2.2	-1.3	-0.1
Number of full brothers	0.4	0.5	1.7	1.3	0.3	0.1	-0.2
Worry too long after embarrassment	1.2	2.0	3.4	0.6	-1.0	1.7	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.6	-0.1	0.8	0.4
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	0.5	0.2	-0.8	-0.9
Number of children fathered	0.6	0.6	2.3	-1.5	0.1	0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	3.2	1.8	-1.2	0.2	1.8
Age at first live birth	1.4	2.4	6.0	-1.4	-2.4	-0.5	1.3
Pulse wave peak to peak time	0.4	0.5	0.8	-0.9	-0.1	-0.9	0.5
Health satisfaction	0.6	0.7	1.7	0.7	-1.3	0.2	-0.9
Shortness of breath walking on level ground	1.1	1.3	3.3	1.8	1.3	0.1	0.4
Qualifications: College or University degree	0.8	2.6	4.2	-2.0	-1.6	-1.3	1.3
Eye problems/disorders: None of the above	1.3	1.5	2.0	-1.4	-1.4	0.9	1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-0.5	0.9	0.7	1.0
Emphysema/chronic bronchitis	1.0	1.2	1.6	0.5	1.3	-1.2	-1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	0.7	0.8	0.4	-0.7	0.3
Neck or shoulder pain in last month	0.9	1.2	2.8	0.1	-1.7	-1.3	-0.7
Medication: Blood pressure	0.7	1.3	4.4	-2.1	-0.5	0.6	-0.2
Angina (self-reported)	0.7	1.0	1.8	-1.1	1.4	0.5	-0.7
Migraine (self-reported)	2.0	2.5	7.8	-2.8	-1.4	-0.1	0.2
Medication: Ibuprofen	0.9	1.0	2.6	-1.6	-0.7	0.4	-0.9
Medication: Allopurinol	0.6	0.8	1.9	0.6	0.4	-0.8	-1.4
Medication: Omeprazole	0.2	0.3	1.0	1.0	0.1	-0.4	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.1	-0.6	0.9	-0.0
Mean time to correctly identify matches	1.5	2.8	6.0	1.1	-2.0	2.5	0.1
Heart disease (mother)	1.8	2.2	5.4	-0.6	2.3	1.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.3	0.4	-0.7	-1.8	0.9
Whole body fat mass	0.5	2.0	4.7	-1.5	2.2	-0.1	-1.0
Leg fat mass (right)	0.6	2.2	4.1	-1.6	2.0	-0.9	-1.1
Arm predicted mass (right)	0.4	2.3	8.4	0.3	2.9	-0.8	-0.3
Pulse rate, automated reading	0.4	1.3	4.4	-0.7	0.3	2.1	-0.5
Alcohol intake frequency.	0.6	1.3	2.7	-1.6	0.5	-0.8	-1.3
Comparative height size at age 10	0.3	1.8	3.2	-1.8	-0.7	0.8	-1.7
Number of full sisters	1.0	1.2	2.2	-1.0	1.1	-1.5	-0.6
Suffer from ‘nerves’	1.6	2.5	5.2	0.1	1.4	1.6	-2.3
Overall health rating	0.5	1.2	3.4	-0.9	0.3	0.6	-1.9
Chest pain or discomfort	0.5	0.7	1.5	0.3	1.2	-0.5	-0.9
Had major operations	1.1	1.3	2.7	0.4	1.6	1.4	0.7
Age at last live birth	0.6	0.8	2.1	-1.4	-1.0	-0.0	0.4
Family relationship satisfaction	1.2	1.5	3.5	0.2	-1.9	-1.6	0.2
Leg pain on walking	2.1	2.6	6.8	2.6	0.2	-1.4	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.3	-0.7	-0.4	1.8	-0.2
Commuting to job workplace: Car/motor vehicle	3.4	3.9	6.7	-1.6	-2.5	-2.6	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.2	0.2	-1.5	1.0	-0.1
Medication: Aspirin	0.4	0.5	1.5	-0.0	0.1	0.8	-1.2
Supplements: Vitamin C	0.5	0.6	1.1	1.0	0.9	-0.2	0.6
Knee pain experienced in last month	0.5	0.8	1.2	-1.1	-0.8	-0.5	-1.0
Hypertension (Self-reported)	0.3	0.9	1.6	-1.0	-1.0	-1.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	5.8	2.4	0.4	-0.4	2.4
Illnesses of father: Heart disease	0.3	0.4	1.1	-1.0	0.7	-0.2	-0.0
Illnesses of siblings: Diabetes	0.8	0.9	2.9	0.4	0.3	1.7	-0.7
Smoking status: Previous	0.4	0.6	1.8	0.5	0.6	-1.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.9	-0.3	1.1	2.2	-0.7
Whole body fat-free mass	0.3	1.7	6.3	-0.3	2.5	-0.2	-0.5
Leg fat-free mass (right)	0.3	1.8	5.4	-0.6	2.3	0.2	-1.2
Arm fat percentage (left)	0.4	1.7	3.1	-1.5	1.8	-0.2	-1.1
Average weekly red wine intake	0.3	0.5	1.2	-0.6	-0.6	-0.4	-1.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.3	0.6	1.8	1.3	-0.1
Mood swings	1.0	1.8	3.9	2.0	-0.5	-0.2	1.7
Loneliness, isolation	1.8	2.5	7.4	1.4	-0.3	0.6	2.7
Long-standing illness, disability or infirmity	0.4	0.6	2.1	-1.5	-0.1	-0.2	-0.5
Ever had bowel cancer screening	0.2	0.2	0.5	0.3	0.6	0.1	-0.7
Diabetes diagnosed by doctor	0.6	0.9	2.8	-0.0	1.7	0.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.6	-0.0	1.0	0.2
Friendships satisfaction	0.4	0.5	0.8	-0.8	-0.7	-0.1	0.9
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.2	-0.7	-0.2	1.2
Commuting to job workplace: Walk	0.6	0.6	1.1	-0.7	0.6	0.7	1.1
Eye problems/disorders: Cataract	1.8	2.1	5.3	2.3	-1.4	-1.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.7	0.8	-0.2	0.6	-0.6
Medication for cholesterol	0.6	0.9	1.7	1.2	1.3	0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	6.9	-2.4	-2.6	0.3	-0.7
Back pain experienced in last month	0.4	0.5	1.0	-0.7	0.5	-1.0	-0.6
Mineral and other dietary supplements	0.9	1.2	3.6	0.3	1.9	-0.4	0.9
Breast cancer (self-reported)	1.9	2.3	6.3	-1.1	-1.2	-2.5	-0.4
Asthma (self-reported)	0.1	0.1	0.3	-0.3	0.5	0.4	-0.1
Osteoporosis (self-reported)	0.9	1.1	4.3	0.1	-2.1	0.0	0.4
Osteoarthritis (self-reported)	0.5	0.7	1.4	-1.2	-0.6	0.8	-0.6
Medication: Aspirin	0.2	0.3	1.0	-0.1	0.3	0.4	-1.0
Medication: Gliclazide	1.8	2.0	6.7	-0.5	2.6	0.4	1.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	1.1	-0.9	-0.4	-0.1
Smoking status: Current	1.4	2.2	3.1	-1.7	1.8	1.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-0.9	1.0	0.5	0.4
Whole body water mass	0.3	1.5	5.7	-0.4	2.4	-0.3	-0.2
Leg predicted mass (right)	0.3	1.7	5.1	-0.6	2.3	0.2	-1.1
Arm fat mass (left)	0.5	2.0	5.5	-1.1	2.3	-0.2	-1.2
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	-0.9	-0.7	0.7	-0.3
Average weekly champagne plus white wine intake	1.3	1.8	5.4	-0.3	-0.5	2.3	1.2
Miserableness	0.9	1.5	4.8	0.5	-0.9	-0.5	2.2
Guilty feelings	1.6	2.3	4.8	1.1	-1.6	0.9	2.2
Wears glasses or contact lenses	0.8	0.9	1.6	-1.3	-1.0	-1.0	-0.1
Ever taken oral contraceptive pill	0.1	0.2	0.2	0.4	0.2	-0.5	-0.5
Hearing aid user	0.4	0.5	0.7	0.5	-0.7	-0.8	-0.8
Mother’s age at death	1.0	1.3	3.0	-1.7	-0.9	-0.8	0.8
Financial situation satisfaction	1.0	1.3	2.6	-1.2	0.3	-1.6	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.2	-0.8	-0.7	-1.5	-0.4
Commuting to job workplace: Public transport	0.6	0.7	1.4	1.2	0.3	0.9	0.6
Eye problems/disorders: Glaucoma	2.2	2.6	8.5	0.1	2.9	-0.8	-1.0
Medication: Blood pressure	0.1	0.1	0.3	-0.6	-0.0	0.3	-0.3
Pain type(s) experienced in last month: Hip pain	1.6	2.0	6.7	-0.6	-0.1	-0.9	-2.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.4	-1.1	-1.2	0.2	-0.7
High cholesterol (Self-reported)	0.2	0.3	0.9	-0.3	1.0	0.2	0.4
Medication: Bendroflumethiazide	0.2	0.3	0.7	0.3	0.4	0.5	-0.9
Medication: Paracetamol	0.1	0.2	0.5	0.0	0.7	-0.1	-0.6
Medication: Lisinopril	0.3	0.4	1.5	-1.2	-0.3	0.4	-0.2
Medication: Atorvastatin	0.9	1.1	3.1	-0.9	0.1	-0.8	1.7
Illnesses of father: High blood pressure	0.9	1.1	3.3	-1.8	0.3	0.9	0.5
Alcohol drinker status: Never	0.2	0.2	0.4	-0.4	-0.5	0.4	-0.6
Ever smoked	0.4	0.7	1.0	-0.8	1.0	-0.9	-0.4
Basal metabolic rate	0.3	1.9	7.0	-0.5	2.6	0.0	-0.7
Leg fat percentage (left)	0.6	2.2	4.2	-2.0	1.9	-0.7	-0.6
Arm fat-free mass (left)	0.4	1.8	6.2	-0.4	2.5	-0.9	-0.1
Number of operations (self-reported)	0.7	1.0	1.7	-1.1	1.3	0.7	-0.7
Average weekly beer plus cider intake	0.0	0.1	0.2	0.4	0.2	-0.2	-0.1
Irritability	0.2	0.3	1.2	-0.1	-0.3	0.2	1.1
Risk taking	0.7	1.0	3.2	0.7	1.8	0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.0	-0.3	-0.7	-0.5
Fractured/broken bones in last 5 years	1.0	1.3	3.2	-1.3	-0.2	1.8	-0.6
Age started oral contraceptive pill	0.9	1.1	2.0	-0.1	-1.2	0.9	1.4
Diastolic blood pressure, automated reading	0.3	1.0	2.2	1.3	1.5	0.1	-0.7
Ever depressed for a whole week	0.7	0.8	3.2	0.2	-0.1	-1.8	0.2
Unable to work because of sickness or disability	1.1	1.4	3.3	-0.2	1.4	0.3	-1.8
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.6	0.8	-0.5	-0.3
Myopia	1.6	2.3	4.9	-1.4	-0.1	1.5	-2.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.4	0.3	0.6	1.2	-0.1
Cholesterol lowering medication	0.0	0.0	0.1	-0.1	0.1	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.5	1.6	-0.2	0.0	0.2
Pain experienced in last month	0.5	0.8	1.5	0.8	1.2	0.6	0.7
Supplements: Calcium	2.2	2.4	6.2	-0.3	-2.5	-1.8	0.5
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.7	0.5	0.1	-0.1
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	1.3	-1.9	-0.8	0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.6	0.8	-0.8	0.6	0.6
Heart disease (siblings)	1.6	2.0	4.4	1.8	2.1	-0.5	0.2
Alcohol drinker status: Previous	1.6	1.8	5.2	0.4	1.3	-0.3	-2.3
Pack years of smoking	0.3	0.4	1.0	-1.0	0.5	-0.6	0.1
Impedance of whole body	0.5	2.8	9.4	-0.4	-3.1	1.2	-0.3
Leg fat mass (left)	0.6	2.4	5.4	-1.5	2.3	-0.7	-1.1
Arm predicted mass (left)	0.4	1.9	7.2	-0.1	2.7	-0.7	-0.1