Hub : Genes

MCTP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0740 0.0280 0.0036 -0.002 0.008 0.005 0.01 0.000 0.80 0.03100 0.076 0.019 0.29
2 GTEx Brain Cerebellum 0.2690 0.0920 0.0057 -0.010 NA 0.006 NA 0.003 0.87 NA 0.210 NA 0.26
3 TCGA Breast Invasive Carcinoma 0.0305 0.0138 0.0038 -0.001 0.017 0.005 NA -0.001 0.77 0.00013 0.030 NA 0.72
4 TCGA Kidney Renal Papillary Cell Carcinoma 0.1720 0.0690 0.0082 -0.003 -0.002 -0.004 NA -0.005 0.54 0.41000 0.740 NA 0.86

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.8 2.8 6.5 -2.1 -0.4 0.1 2.5
Bipolar Disorder or Schizophrenia 1.3 3.1 6.8 -2.6 -0.8 -0.6 2.2
Depressed Affect (Nagel 2018) 1.5 3.1 7.3 1.0 -2.0 -0.5 2.7
Depression (Nagel 2018) 0.2 0.3 0.9 0.1 0.1 1.0 0.2
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.5 -1.6 -1.0 -0.8 -0.1
Neuroticism (Nagel 2018) 0.7 1.6 2.6 0.6 -1.6 1.1 1.5
Schizophrenia (2018) 0.5 1.1 2.5 -1.6 -0.7 -0.9 0.8
Schizophrenia vs Biploar Disorder 1.5 1.9 4.4 2.1 1.7 0.4 -0.6
Worry (Nagel 2018) 0.4 0.8 2.6 0.4 -0.1 1.6 -0.6
Alzheimer’s Disease (in mother) 0.8 0.9 1.7 -0.1 -1.3 -1.0 0.9
Alzheimer’s Disease (in father) 0.8 0.9 1.4 -1.2 0.8 0.8 -0.9
Alzheimer’s Disease (including proxy) 0.2 0.3 0.9 -0.6 -0.9 -0.4 -0.0
Crohns Disease (2017) 0.6 1.4 4.4 1.1 -0.2 0.1 2.1
Irritable Bowel Disease (IBD) 0.5 1.2 3.6 0.4 0.8 -0.7 1.9
Ulcerative Colitis (UC) 0.5 0.9 1.1 -0.5 1.0 -1.1 1.1
Major Depression (MDD) 0.3 0.3 0.9 -0.0 0.6 0.4 -0.9
Reaction Time 1.5 2.9 5.7 1.4 -1.8 2.4 0.6
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.0 -1.7 -1.7 -1.4 -0.5
Breast Cancer 0.7 1.7 4.2 -1.3 2.0 0.5 -0.8
Ovarian Cancer 0.7 1.0 2.5 -0.9 -0.5 0.5 1.6
Prostate Cancer 1.7 2.4 4.9 -0.8 0.2 -2.2 -2.0
Age at First Birth 0.7 1.1 1.5 -1.2 1.0 1.2 -0.6
Bipolar Disorder (2011) 5.3 5.1 10.1 -3.2 -1.2 -0.1 3.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 0.7 0.1 -0.8 0.1
Coronary Artery Disease (CAD) 0.8 0.9 2.7 1.6 0.2 -1.0 -0.1
Crohns Disease (2012) 0.4 0.6 2.2 0.1 -0.2 -0.3 1.5
Mean Putamen Volume 1.2 1.3 2.8 -1.7 0.3 1.5 -0.5
Fasting Glucose 1.4 1.7 6.0 -0.6 2.5 0.6 -0.0
HbA1C 0.3 0.3 0.6 0.2 0.3 0.8 0.7
HDL Cholesterol 0.5 0.8 2.0 -0.7 -1.4 -0.6 -0.6
LDL Cholesterol 0.5 0.7 1.7 1.3 -0.6 0.3 -0.9
Lupus 0.8 1.1 2.2 -0.3 1.4 1.5 -0.5
Neuroticism (2016) 0.8 1.1 3.3 0.7 0.8 1.8 0.0
Primary Biliary Cirrhosis 0.3 0.4 1.3 0.3 1.1 0.2 -0.4
Rheumatoid Arthritis 1.2 1.7 3.6 -1.3 0.4 1.2 -1.9
Schizophrenia (2014) 0.5 1.0 2.4 -0.7 -0.5 -1.0 1.6
Triglycerides 0.3 0.5 1.9 0.3 -1.4 -0.2 0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.1 0.4 0.2 1.1 -0.4
Ulcerative Colitis 0.3 0.5 1.1 0.0 1.1 -0.4 0.8
Blood Eosinophil Count 0.1 0.9 1.7 -0.8 1.3 0.8 -0.8
Blood Platelet Count 0.1 1.4 2.8 -1.7 1.4 -0.3 -0.9
Blood Red Count 0.1 0.8 1.9 0.3 1.4 1.0 -0.4
Blood White Count 0.2 1.6 3.8 0.3 2.0 1.2 -0.9
Heel T-Score 0.1 0.5 0.6 -0.6 -0.8 -0.7 -0.7
BMI 0.7 3.8 8.7 -0.7 3.0 -1.3 -2.0
Height 0.0 0.7 2.7 0.0 0.2 0.2 -1.7
Waist Hip Ratio (WHR) 0.1 0.5 1.2 -0.0 -0.8 -1.1 -0.1
Systolic Blood Pressure 0.4 1.8 5.6 -0.0 1.0 0.8 -2.4
Smoking Status 0.5 1.2 2.5 -0.4 1.5 -0.2 -1.6
Allergy or Eczema 0.4 1.0 3.5 -1.9 -0.2 0.1 0.7
Cardiovascular Disease 0.3 0.8 2.6 0.1 0.4 -0.7 -1.6
Hypothyroidism (self reported) 0.7 1.6 5.0 -2.2 -0.7 -0.9 -0.1
Respiratory disease 0.3 0.7 1.7 0.0 1.3 -0.4 -1.0
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 -0.7 1.1 -0.5 0.5
Lung FEV1/FVC ratio 2.0 10.1 38.3 -6.2 -0.5 0.6 -1.2
Lung FVC 0.7 3.8 9.3 3.1 1.6 0.5 1.7
Neuroticism 0.3 0.7 1.2 0.3 -0.4 1.1 1.1
Chronotype (morning person) 1.3 3.1 10.2 3.2 -0.4 0.2 1.4
Hair Pigment 0.0 0.9 2.0 -0.8 -1.4 0.1 -0.9
Tanning 0.2 2.4 3.9 0.3 -1.6 -2.0 1.7
Hand grip strength (left) 0.7 2.0 4.7 -1.6 0.7 -2.2 -0.3
Number of treatments/medications taken 0.4 0.8 1.9 -1.4 -0.4 0.3 -1.0
Average weekly spirits intake 0.5 0.7 1.5 -0.3 1.0 -0.3 1.2
Sensitivity / hurt feelings 0.7 1.2 2.2 1.5 0.4 1.5 -0.6
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.4 1.5 0.4 1.4 0.9
Hearing difficulty/problems: Yes 0.5 0.8 1.9 -0.2 0.9 0.7 -1.4
Relative age of first facial hair 0.5 1.1 1.9 -1.4 0.8 -0.3 -1.4
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 0.7 0.2 -0.9 0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.1 0.3 -1.1 -0.1 0.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.1 -1.0 -0.4 -0.1 -1.0
Systolic blood pressure, automated reading 1.0 3.0 7.8 0.7 2.8 0.4 -1.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.1 0.0 0.8 1.1 -0.7
Angina 0.9 1.2 2.3 -1.5 1.3 0.6 -0.7
Medication for hormone replacement therapy 3.6 4.1 11.1 -1.2 -3.3 -1.7 0.9
Vitamin and mineral supplements 0.9 1.2 3.0 1.3 -0.0 -1.7 -0.1
Supplements: Zinc 0.1 0.1 0.1 0.4 0.2 -0.2 -0.4
Medication: Co-codamol 0.0 0.0 0.0 0.2 -0.1 -0.0 -0.2
Medication: Metformin 0.6 0.8 1.9 -1.4 1.2 0.3 0.1
Diabetes (father) 0.4 0.5 1.0 -1.0 0.5 -0.6 -0.7
Diabetes (mother) 1.0 1.3 3.1 -1.4 1.8 -0.3 0.4
Severe depression (siblings) 0.4 0.4 0.6 0.7 -0.8 0.0 0.8
Pack years adult smoking proportion 0.4 0.6 1.9 -1.4 0.6 -0.6 0.1
Impedance of leg (right) 0.4 1.9 7.4 -0.2 -2.7 0.3 0.5
Leg fat-free mass (left) 0.3 1.4 4.2 -0.7 2.0 0.1 -1.0
Trunk fat percentage 0.3 1.4 2.0 -1.4 1.3 -0.2 -1.3
Hand grip strength (right) 0.7 2.0 4.5 -1.8 0.5 -2.1 -0.2
Townsend deprivation index at recruitment 0.2 0.2 0.8 -0.1 0.9 -0.1 -0.2
Current tobacco smoking 1.5 2.4 3.7 -1.9 1.7 1.6 -0.7
Average weekly fortified wine intake 1.0 1.1 2.4 -0.5 1.2 0.7 -1.5
Maternal smoking around birth 0.2 0.3 1.0 -0.1 -0.4 0.1 -1.0
Fed-up feelings 1.0 1.8 3.6 1.9 -0.9 0.6 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.8 1.4 0.4 1.2 1.3
Relative age voice broke 1.0 1.5 4.4 -0.3 1.1 0.3 -2.1
Taking other prescription medications 0.3 0.5 1.5 0.4 0.6 1.2 -0.1
Age when periods started (menarche) 1.2 2.8 9.2 3.0 1.4 0.3 0.4
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 2.0 1.2 -1.4 0.9 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 0.3 0.7 -0.5 -0.6
Tinnitus: Yes, but not now, but have in the past 2.5 2.7 5.7 2.4 1.7 -1.3 -0.9
Qualifications: CSEs or equivalent 1.7 2.3 7.3 0.1 -0.1 2.7 -1.3
Serious illness, injury or assault to yourself 2.1 2.5 4.9 -2.2 1.1 -1.1 -1.6
High blood pressure 0.2 0.6 1.4 -0.6 -0.8 -1.2 -0.3
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.5 -1.9 0.1 -0.6 0.7
Multivitamins +/- minerals 1.4 1.7 2.7 -1.6 0.7 1.6 -1.1
Stomach or abdominal pain in last month 0.7 0.8 1.7 -1.3 -0.3 -0.1 -1.2
Supplements: Glucosamine 0.8 1.0 2.5 -0.8 -1.6 0.5 -0.9
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.4 -0.6 0.8 -1.2 1.2
Medication: Atenolol 0.5 0.6 1.2 -1.1 -0.2 0.9 -0.6
Medication: Levothyroxine sodium 0.3 0.5 1.3 -1.1 0.8 -0.4 0.4
Sitting height 0.2 1.5 2.9 1.1 1.7 1.0 -1.1
Chronic bronchitis/emphysema (father) 0.5 0.6 1.7 0.7 -0.6 1.3 0.3
High blood pressure (mother) 0.9 1.3 3.7 -0.9 0.5 1.9 -0.5
Body mass index (BMI) 0.7 2.8 8.8 -0.8 3.0 -1.0 -0.9
Impedance of leg (left) 0.3 1.4 5.3 -0.2 -2.3 0.2 0.1
Leg predicted mass (left) 0.3 1.4 4.1 -0.7 2.0 0.1 -1.0
Trunk fat mass 0.4 1.6 3.1 -1.5 1.8 -0.2 -0.9
Waist circumference 0.3 1.3 3.5 -0.8 1.9 -0.5 -0.9
Number of incorrect matches in round 0.4 0.7 0.8 0.7 -0.9 0.9 0.9
Past tobacco smoking 0.2 0.4 0.8 -0.0 -0.9 0.8 0.1
Alcohol usually taken with meals 0.9 1.5 3.0 -1.7 -0.4 0.9 1.4
Nervous feelings 1.1 2.0 4.6 1.2 0.9 2.2 -1.0
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 3.6 1.9 -0.9 1.3 1.6
Hearing difficulty/problems with background noise 0.9 1.5 5.4 0.6 -0.3 2.3 0.2
Hair/balding pattern: Pattern 2 0.8 1.0 1.8 0.7 1.3 0.1 -1.3
Had menopause 0.1 0.2 0.4 0.3 0.4 0.6 0.2
Had other major operations 0.1 0.1 0.4 0.1 -0.1 -0.2 0.6
Forced vital capacity (FVC) 0.4 1.7 3.4 1.8 1.7 0.6 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.0 0.5 0.1 -1.0 -0.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.9 0.3 0.8 -1.7 -0.0
Qualifications: None of the above 0.5 1.0 2.9 1.7 1.1 -0.3 -0.1
Financial difficulties in last 2 years 1.0 1.3 3.8 -0.8 1.9 0.2 -0.9
Mouth/teeth dental problems 1.0 1.5 5.6 0.4 -0.2 -2.4 -0.4
Heart attack 1.4 1.8 4.0 1.6 -2.0 -0.6 0.7
Allergy 0.1 0.2 0.5 0.7 -0.4 -0.3 -0.2
Pain all over the body in last month 2.4 2.5 6.1 1.3 2.5 -0.3 -1.5
Diabetes (self-reported) 0.3 0.5 1.1 -0.2 1.0 0.5 0.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 0.0 0.1 0.5 0.1
Medication: Ramipril 0.9 1.2 2.6 -1.6 -0.6 1.0 -0.9
Medication: Simvastatin 0.4 0.6 1.4 0.2 0.4 1.2 -0.9
Fluid intelligence score 0.3 0.5 1.2 -0.1 -0.4 -1.1 -0.8
Illnesses of siblings 1.3 1.8 4.7 -0.8 -2.2 -1.1 0.8
Neuroticism score 0.4 0.9 2.2 1.5 -0.0 1.2 0.4
Weight 0.4 2.2 6.5 -0.9 2.5 -0.3 -1.1
Impedance of arm (right) 0.7 3.4 9.6 -0.8 -3.1 1.8 -0.4
Arm fat percentage (right) 0.4 1.5 2.6 -1.6 1.6 -0.2 -0.9
Trunk fat-free mass 0.3 1.5 6.1 -0.0 2.5 -0.1 0.2
Hip circumference 0.4 1.8 4.9 -0.7 2.2 0.2 -1.3
Time employed in main current job 0.5 0.6 1.6 0.5 1.3 0.5 -0.4
Alcohol intake versus 10 years previously 0.6 0.8 2.5 0.3 -1.6 -0.7 0.6
Father’s age at death 0.4 0.6 2.0 -0.1 -0.5 -1.4 0.0
Worrier / anxious feelings 0.2 0.4 1.1 -0.0 -1.1 0.5 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.1 1.5 2.0 0.8 -1.6
Falls in the last year 1.4 1.9 3.8 -0.6 1.4 1.3 -2.0
Hair/balding pattern: Pattern 3 0.4 0.6 2.3 -0.2 -0.0 0.1 1.5
Number of live births 0.6 0.9 1.7 0.6 1.3 -1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.4 0.1 1.2 0.9 0.3
Pulse rate 1.1 1.8 3.2 -1.8 -0.0 1.8 -0.9
Happiness 1.8 2.2 6.3 -0.8 -2.5 -0.9 0.9
Noisy workplace 0.4 0.5 1.2 1.1 -0.4 0.6 -0.5
Qualifications: A levels/AS levels or equivalent 0.6 1.3 2.8 -1.0 -0.3 -1.7 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.6 0.8 -0.6 -0.7 0.3
Mouth/teeth dental problems: Dentures 1.0 1.7 5.4 0.7 0.6 2.3 0.7
Asthma 0.1 0.2 0.3 0.1 0.6 0.5 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.9 -1.7 -1.6 -0.2 -0.5
Medication: Cholesterol lowering 0.7 1.0 2.0 -1.4 0.5 1.0 -0.9
Depression (self-reported) 1.1 1.3 1.9 -1.4 1.0 1.1 1.1
Medication: Lansoprazole 0.8 0.9 2.0 -1.1 -0.6 -0.3 1.4
Prospective memory result 0.1 0.1 0.1 0.3 0.3 0.3 -0.2
Lung cancer (father) 0.8 0.9 2.7 0.5 0.8 -0.0 -1.7
Illnesses of mother 1.3 1.6 2.4 0.9 -1.1 -1.5 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.6 0.7 0.3 1.2 -0.5
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 1.0 0.1 1.1 -0.6
Impedance of arm (left) 0.9 4.1 10.2 -0.6 -3.2 2.2 -1.0
Arm fat mass (right) 0.5 2.2 5.7 -1.3 2.4 -0.7 -1.1
Trunk predicted mass 0.3 1.6 6.2 -0.1 2.5 -0.1 0.2
Standing height 0.1 0.7 2.0 -0.1 -0.4 1.4 -0.9
Length of working week for main job 0.8 0.9 2.8 0.1 -1.7 -0.7 -0.6
Exposure to tobacco smoke at home 0.2 0.2 0.4 0.1 0.4 0.7 -0.5
Breastfed as a baby 1.9 2.3 6.2 -0.3 -0.9 -1.5 2.5
Tense / ‘highly strung’ 1.1 1.8 4.3 0.7 1.0 2.1 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.4 -0.9 0.8 -0.5 -1.5
Hair/balding pattern: Pattern 4 0.4 0.9 2.0 -1.4 -1.0 -0.6 0.6
Birth weight of first child 0.3 0.5 0.9 0.4 -0.6 0.7 0.9
Peak expiratory flow (PEF) 0.6 1.4 4.4 -0.6 2.1 -0.5 0.7
Pulse wave reflection index 1.6 2.0 4.0 1.5 1.4 0.2 -2.0
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.3 1.1 0.3 0.1 -0.2
Loud music exposure frequency 0.5 0.5 0.9 -0.5 -0.9 1.0 -0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.3 -0.8 1.1 0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.5 0.5 0.6 0.3 0.7
Blood clot in the leg (DVT) 0.4 0.5 1.0 0.6 -0.6 1.0 0.4
Medication: Paracetamol 0.0 0.0 0.1 0.1 0.3 -0.2 0.0
Headache pain in last month 1.8 3.0 5.1 -1.5 -2.1 2.3 0.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.8 1.7 -0.0 -0.8 0.6
Glaucoma (self-reported) 1.5 1.7 4.8 -1.2 2.2 -0.1 -0.8
Gout (self-reported) 0.4 0.5 1.8 1.3 0.2 0.0 -0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.9 -0.6 -0.2 -0.9 0.3
Medication: Amlodipine 1.1 1.6 4.4 -0.5 -0.7 -1.1 -2.1
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.5 0.9 -1.0 -1.2 -0.2
Birth weight 0.6 1.2 2.5 1.3 1.6 0.8 -0.3
Chronic bronchitis/emphysema (mother) 1.6 1.9 5.3 0.9 1.2 2.3 -0.2
High blood pressure (siblings) 1.3 1.9 3.3 -1.2 1.5 1.8 -0.6
Forced vital capacity (FVC), Best measure 0.4 1.4 4.0 2.0 0.7 1.0 0.2
Body fat percentage 0.4 1.4 3.2 -1.8 1.3 -0.4 -0.8
Leg fat percentage (right) 0.5 1.8 3.9 -2.0 1.5 -0.8 -0.6
Arm fat-free mass (right) 0.4 2.2 8.4 0.2 2.9 -0.7 -0.1
Exposure to tobacco smoke outside home 0.7 1.0 1.6 1.0 1.2 -0.2 -1.2
Comparative body size at age 10 0.7 1.9 4.8 -1.0 2.2 -1.3 -0.1
Number of full brothers 0.4 0.5 1.7 1.3 0.3 0.1 -0.2
Worry too long after embarrassment 1.2 2.0 3.4 0.6 -1.0 1.7 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.6 -0.1 0.8 0.4
Wheeze or whistling in the chest in last year 0.2 0.4 0.8 0.5 0.2 -0.8 -0.9
Number of children fathered 0.6 0.6 2.3 -1.5 0.1 0.3 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 3.2 1.8 -1.2 0.2 1.8
Age at first live birth 1.4 2.4 6.0 -1.4 -2.4 -0.5 1.3
Pulse wave peak to peak time 0.4 0.5 0.8 -0.9 -0.1 -0.9 0.5
Health satisfaction 0.6 0.7 1.7 0.7 -1.3 0.2 -0.9
Shortness of breath walking on level ground 1.1 1.3 3.3 1.8 1.3 0.1 0.4
Qualifications: College or University degree 0.8 2.6 4.2 -2.0 -1.6 -1.3 1.3
Eye problems/disorders: None of the above 1.3 1.5 2.0 -1.4 -1.4 0.9 1.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.0 -0.5 0.9 0.7 1.0
Emphysema/chronic bronchitis 1.0 1.2 1.6 0.5 1.3 -1.2 -1.2
Medication for pain relief, constipation, heartburn 0.2 0.4 0.7 0.8 0.4 -0.7 0.3
Neck or shoulder pain in last month 0.9 1.2 2.8 0.1 -1.7 -1.3 -0.7
Medication: Blood pressure 0.7 1.3 4.4 -2.1 -0.5 0.6 -0.2
Angina (self-reported) 0.7 1.0 1.8 -1.1 1.4 0.5 -0.7
Migraine (self-reported) 2.0 2.5 7.8 -2.8 -1.4 -0.1 0.2
Medication: Ibuprofen 0.9 1.0 2.6 -1.6 -0.7 0.4 -0.9
Medication: Allopurinol 0.6 0.8 1.9 0.6 0.4 -0.8 -1.4
Medication: Omeprazole 0.2 0.3 1.0 1.0 0.1 -0.4 0.1
Medication: Seretide 50 evohaler 0.3 0.3 0.9 0.1 -0.6 0.9 -0.0
Mean time to correctly identify matches 1.5 2.8 6.0 1.1 -2.0 2.5 0.1
Heart disease (mother) 1.8 2.2 5.4 -0.6 2.3 1.6 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 3.3 0.4 -0.7 -1.8 0.9
Whole body fat mass 0.5 2.0 4.7 -1.5 2.2 -0.1 -1.0
Leg fat mass (right) 0.6 2.2 4.1 -1.6 2.0 -0.9 -1.1
Arm predicted mass (right) 0.4 2.3 8.4 0.3 2.9 -0.8 -0.3
Pulse rate, automated reading 0.4 1.3 4.4 -0.7 0.3 2.1 -0.5
Alcohol intake frequency. 0.6 1.3 2.7 -1.6 0.5 -0.8 -1.3
Comparative height size at age 10 0.3 1.8 3.2 -1.8 -0.7 0.8 -1.7
Number of full sisters 1.0 1.2 2.2 -1.0 1.1 -1.5 -0.6
Suffer from ‘nerves’ 1.6 2.5 5.2 0.1 1.4 1.6 -2.3
Overall health rating 0.5 1.2 3.4 -0.9 0.3 0.6 -1.9
Chest pain or discomfort 0.5 0.7 1.5 0.3 1.2 -0.5 -0.9
Had major operations 1.1 1.3 2.7 0.4 1.6 1.4 0.7
Age at last live birth 0.6 0.8 2.1 -1.4 -1.0 -0.0 0.4
Family relationship satisfaction 1.2 1.5 3.5 0.2 -1.9 -1.6 0.2
Leg pain on walking 2.1 2.6 6.8 2.6 0.2 -1.4 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.3 -0.7 -0.4 1.8 -0.2
Commuting to job workplace: Car/motor vehicle 3.4 3.9 6.7 -1.6 -2.5 -2.6 -0.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 2.2 0.2 -1.5 1.0 -0.1
Medication: Aspirin 0.4 0.5 1.5 -0.0 0.1 0.8 -1.2
Supplements: Vitamin C 0.5 0.6 1.1 1.0 0.9 -0.2 0.6
Knee pain experienced in last month 0.5 0.8 1.2 -1.1 -0.8 -0.5 -1.0
Hypertension (Self-reported) 0.3 0.9 1.6 -1.0 -1.0 -1.2 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 3.0 5.8 2.4 0.4 -0.4 2.4
Illnesses of father: Heart disease 0.3 0.4 1.1 -1.0 0.7 -0.2 -0.0
Illnesses of siblings: Diabetes 0.8 0.9 2.9 0.4 0.3 1.7 -0.7
Smoking status: Previous 0.4 0.6 1.8 0.5 0.6 -1.4 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.9 -0.3 1.1 2.2 -0.7
Whole body fat-free mass 0.3 1.7 6.3 -0.3 2.5 -0.2 -0.5
Leg fat-free mass (right) 0.3 1.8 5.4 -0.6 2.3 0.2 -1.2
Arm fat percentage (left) 0.4 1.7 3.1 -1.5 1.8 -0.2 -1.1
Average weekly red wine intake 0.3 0.5 1.2 -0.6 -0.6 -0.4 -1.1
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.3 0.6 1.8 1.3 -0.1
Mood swings 1.0 1.8 3.9 2.0 -0.5 -0.2 1.7
Loneliness, isolation 1.8 2.5 7.4 1.4 -0.3 0.6 2.7
Long-standing illness, disability or infirmity 0.4 0.6 2.1 -1.5 -0.1 -0.2 -0.5
Ever had bowel cancer screening 0.2 0.2 0.5 0.3 0.6 0.1 -0.7
Diabetes diagnosed by doctor 0.6 0.9 2.8 -0.0 1.7 0.9 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 -0.6 -0.0 1.0 0.2
Friendships satisfaction 0.4 0.5 0.8 -0.8 -0.7 -0.1 0.9
Qualifications: nursing, teaching 0.3 0.5 1.3 -0.2 -0.7 -0.2 1.2
Commuting to job workplace: Walk 0.6 0.6 1.1 -0.7 0.6 0.7 1.1
Eye problems/disorders: Cataract 1.8 2.1 5.3 2.3 -1.4 -1.1 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.7 0.8 -0.2 0.6 -0.6
Medication for cholesterol 0.6 0.9 1.7 1.2 1.3 0.7 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.8 3.3 6.9 -2.4 -2.6 0.3 -0.7
Back pain experienced in last month 0.4 0.5 1.0 -0.7 0.5 -1.0 -0.6
Mineral and other dietary supplements 0.9 1.2 3.6 0.3 1.9 -0.4 0.9
Breast cancer (self-reported) 1.9 2.3 6.3 -1.1 -1.2 -2.5 -0.4
Asthma (self-reported) 0.1 0.1 0.3 -0.3 0.5 0.4 -0.1
Osteoporosis (self-reported) 0.9 1.1 4.3 0.1 -2.1 0.0 0.4
Osteoarthritis (self-reported) 0.5 0.7 1.4 -1.2 -0.6 0.8 -0.6
Medication: Aspirin 0.2 0.3 1.0 -0.1 0.3 0.4 -1.0
Medication: Gliclazide 1.8 2.0 6.7 -0.5 2.6 0.4 1.0
Illnesses of father: None of the above (group 1) 0.5 0.6 1.3 1.1 -0.9 -0.4 -0.1
Smoking status: Current 1.4 2.2 3.1 -1.7 1.8 1.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.9 -0.9 1.0 0.5 0.4
Whole body water mass 0.3 1.5 5.7 -0.4 2.4 -0.3 -0.2
Leg predicted mass (right) 0.3 1.7 5.1 -0.6 2.3 0.2 -1.1
Arm fat mass (left) 0.5 2.0 5.5 -1.1 2.3 -0.2 -1.2
Number of self-reported non-cancer illnesses 0.3 0.5 0.8 -0.9 -0.7 0.7 -0.3
Average weekly champagne plus white wine intake 1.3 1.8 5.4 -0.3 -0.5 2.3 1.2
Miserableness 0.9 1.5 4.8 0.5 -0.9 -0.5 2.2
Guilty feelings 1.6 2.3 4.8 1.1 -1.6 0.9 2.2
Wears glasses or contact lenses 0.8 0.9 1.6 -1.3 -1.0 -1.0 -0.1
Ever taken oral contraceptive pill 0.1 0.2 0.2 0.4 0.2 -0.5 -0.5
Hearing aid user 0.4 0.5 0.7 0.5 -0.7 -0.8 -0.8
Mother’s age at death 1.0 1.3 3.0 -1.7 -0.9 -0.8 0.8
Financial situation satisfaction 1.0 1.3 2.6 -1.2 0.3 -1.6 -0.9
Tinnitus: Yes, now most or all of the time 0.7 0.9 2.2 -0.8 -0.7 -1.5 -0.4
Commuting to job workplace: Public transport 0.6 0.7 1.4 1.2 0.3 0.9 0.6
Eye problems/disorders: Glaucoma 2.2 2.6 8.5 0.1 2.9 -0.8 -1.0
Medication: Blood pressure 0.1 0.1 0.3 -0.6 -0.0 0.3 -0.3
Pain type(s) experienced in last month: Hip pain 1.6 2.0 6.7 -0.6 -0.1 -0.9 -2.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.4 -1.1 -1.2 0.2 -0.7
High cholesterol (Self-reported) 0.2 0.3 0.9 -0.3 1.0 0.2 0.4
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.3 0.4 0.5 -0.9
Medication: Paracetamol 0.1 0.2 0.5 0.0 0.7 -0.1 -0.6
Medication: Lisinopril 0.3 0.4 1.5 -1.2 -0.3 0.4 -0.2
Medication: Atorvastatin 0.9 1.1 3.1 -0.9 0.1 -0.8 1.7
Illnesses of father: High blood pressure 0.9 1.1 3.3 -1.8 0.3 0.9 0.5
Alcohol drinker status: Never 0.2 0.2 0.4 -0.4 -0.5 0.4 -0.6
Ever smoked 0.4 0.7 1.0 -0.8 1.0 -0.9 -0.4
Basal metabolic rate 0.3 1.9 7.0 -0.5 2.6 0.0 -0.7
Leg fat percentage (left) 0.6 2.2 4.2 -2.0 1.9 -0.7 -0.6
Arm fat-free mass (left) 0.4 1.8 6.2 -0.4 2.5 -0.9 -0.1
Number of operations (self-reported) 0.7 1.0 1.7 -1.1 1.3 0.7 -0.7
Average weekly beer plus cider intake 0.0 0.1 0.2 0.4 0.2 -0.2 -0.1
Irritability 0.2 0.3 1.2 -0.1 -0.3 0.2 1.1
Risk taking 0.7 1.0 3.2 0.7 1.8 0.4 -0.2
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.0 -0.3 -0.7 -0.5
Fractured/broken bones in last 5 years 1.0 1.3 3.2 -1.3 -0.2 1.8 -0.6
Age started oral contraceptive pill 0.9 1.1 2.0 -0.1 -1.2 0.9 1.4
Diastolic blood pressure, automated reading 0.3 1.0 2.2 1.3 1.5 0.1 -0.7
Ever depressed for a whole week 0.7 0.8 3.2 0.2 -0.1 -1.8 0.2
Unable to work because of sickness or disability 1.1 1.4 3.3 -0.2 1.4 0.3 -1.8
Commuting to job workplace: Cycle 0.3 0.3 0.6 0.6 0.8 -0.5 -0.3
Myopia 1.6 2.3 4.9 -1.4 -0.1 1.5 -2.2
Vascular/heart problems diagnosed by doctor 0.2 0.4 1.4 0.3 0.6 1.2 -0.1
Cholesterol lowering medication 0.0 0.0 0.1 -0.1 0.1 0.2 0.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.5 1.6 -0.2 0.0 0.2
Pain experienced in last month 0.5 0.8 1.5 0.8 1.2 0.6 0.7
Supplements: Calcium 2.2 2.4 6.2 -0.3 -2.5 -1.8 0.5
Basal cell carcinoma (self-reported) 0.2 0.2 0.4 0.7 0.5 0.1 -0.1
Heart attack/myocardial infarction (self-reported) 1.2 1.6 3.6 1.3 -1.9 -0.8 0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 0.6 0.8 -0.8 0.6 0.6
Heart disease (siblings) 1.6 2.0 4.4 1.8 2.1 -0.5 0.2
Alcohol drinker status: Previous 1.6 1.8 5.2 0.4 1.3 -0.3 -2.3
Pack years of smoking 0.3 0.4 1.0 -1.0 0.5 -0.6 0.1
Impedance of whole body 0.5 2.8 9.4 -0.4 -3.1 1.2 -0.3
Leg fat mass (left) 0.6 2.4 5.4 -1.5 2.3 -0.7 -1.1
Arm predicted mass (left) 0.4 1.9 7.2 -0.1 2.7 -0.7 -0.1