Hub : Genes

GLRX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0540	0.0260	1.1e-02	0.002	0.014	0.003	0.019	0.007	2.0e-01	6.6e-03	1.4e-01	2.1e-03	4.4e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.1650	0.0374	1.1e-07	0.048	0.082	0.130	0.101	0.111	8.2e-07	1.2e-10	2.2e-16	5.6e-13	3.7e-14
3	YFS	Blood	0.1781	0.0302	0.0e+00	0.083	0.112	0.116	0.117	0.111	7.0e-26	9.3e-35	6.5e-36	3.3e-36	2.6e-34
4	TCGA	Breast Invasive Carcinoma	0.0329	0.0151	2.8e-03	0.001	0.014	0.009	NA	0.008	1.5e-01	4.9e-04	4.8e-03	NA	7.2e-03
5	TCGA	Cervical Squamous Cell Carcinoma	0.1390	0.0540	1.1e-03	-0.003	0.067	0.022	NA	0.006	5.2e-01	3.1e-04	2.8e-02	NA	1.5e-01
6	TCGA	Brain Lower Grade Glioma	0.0404	0.0189	9.2e-04	0.039	0.028	0.013	NA	0.028	2.9e-05	3.3e-04	1.2e-02	NA	3.1e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.4	1.4	0.3	-0.4	-0.9	0.2	-0.1	1.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.2	-0.9	-0.2	-0.3	-1.1	0.0	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-0.5	0.6	-1.5	-1.0	-0.0	-0.2
Depression (Nagel 2018)	0.0	0.0	0.1	0.2	0.2	-0.1	0.1	0.3	0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.9	0.2	-0.9	0.1	0.2	-1.4	0.3
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.9	1.3	-0.7	-0.7	0.6	-0.5
Schizophrenia (2018)	0.4	0.7	2.2	-1.4	0.1	0.3	-1.5	0.1	0.2
Schizophrenia vs Biploar Disorder	0.5	0.7	2.1	-0.7	0.5	-0.9	-0.3	1.4	0.6
Worry (Nagel 2018)	0.4	0.8	2.2	-1.5	0.7	0.3	-0.3	1.2	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	-1.0	-0.6	-1.0	-0.7	-1.2	-0.2
Alzheimer’s Disease (in father)	1.5	1.6	6.8	0.1	0.1	-2.6	-1.3	-0.7	0.8
Alzheimer’s Disease (including proxy)	0.6	0.8	3.1	-1.1	-0.2	-1.8	-0.4	-0.6	0.0
Crohns Disease (2017)	1.3	2.9	5.2	0.7	-1.3	1.8	2.3	1.5	-2.1
Irritable Bowel Disease (IBD)	1.4	3.2	5.3	1.0	-1.2	2.2	2.3	1.5	-2.1
Ulcerative Colitis (UC)	0.8	1.4	2.9	-0.1	-1.1	1.3	1.7	0.5	-1.6
Major Depression (MDD)	0.3	0.4	1.0	0.8	-0.1	-0.0	-1.0	0.9	-0.1
Reaction Time	1.1	2.1	5.9	-2.4	-1.9	0.5	0.2	-1.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.5	0.3	-0.0	0.3	1.2	-0.2	0.1
Breast Cancer	0.4	1.0	2.0	1.3	0.4	-1.3	-0.7	0.4	1.4
Ovarian Cancer	0.7	0.9	2.0	1.4	-0.7	0.3	-0.5	-1.2	1.2
Prostate Cancer	0.7	1.0	2.6	-0.8	-1.6	1.4	-0.4	-0.0	-0.8
Age at First Birth	0.4	0.7	2.1	-1.5	0.9	-0.5	0.0	-0.2	-0.8
Bipolar Disorder (2011)	1.2	1.2	2.9	-1.7	-0.9	-0.4	-0.8	-1.6	0.3
Body Mass Index (BMI) (2010)	1.7	2.4	4.6	1.0	0.6	2.1	1.7	1.6	-1.7
Coronary Artery Disease (CAD)	1.0	1.1	2.5	-0.5	-1.3	1.6	-0.0	-0.9	-1.3
Crohns Disease (2012)	0.4	0.7	1.8	0.6	-0.1	0.5	1.3	1.1	-0.7
Mean Putamen Volume	1.7	2.0	4.9	-1.8	-0.1	-2.2	-0.8	-1.1	1.4
Fasting Glucose	0.6	0.7	2.3	1.5	-1.0	0.2	-0.9	0.2	-0.5
HbA1C	0.7	0.8	1.9	0.5	-0.9	1.4	0.8	1.1	-0.2
HDL Cholesterol	0.4	0.6	2.7	0.2	1.6	-0.6	-0.3	0.7	0.5
LDL Cholesterol	0.2	0.3	0.7	0.4	-0.4	-0.2	-0.8	-0.7	-0.2
Lupus	0.1	0.2	0.5	0.2	0.5	0.4	0.1	-0.7	-0.4
Neuroticism (2016)	0.3	0.5	1.4	1.2	-0.7	-0.9	-0.1	0.3	0.6
Primary Biliary Cirrhosis	1.1	1.6	2.8	-0.7	0.7	1.6	1.1	1.3	-1.7
Rheumatoid Arthritis	1.4	1.9	3.7	1.5	1.1	-1.7	-0.4	-1.2	1.9
Schizophrenia (2014)	0.4	0.8	2.2	-0.7	0.4	-0.4	-1.5	0.8	1.0
Triglycerides	0.2	0.4	1.0	0.1	0.2	0.9	0.1	0.7	-1.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.2	0.8	-0.8	0.6	0.3	-0.3
Ulcerative Colitis	0.6	0.8	2.4	0.8	-0.4	1.6	0.8	0.5	-1.0
Blood Eosinophil Count	0.1	0.5	1.2	0.7	0.3	0.2	0.9	1.1	-0.4
Blood Platelet Count	0.2	2.5	5.2	1.5	-0.0	-2.3	-1.2	-1.6	1.8
Blood Red Count	0.1	0.6	1.7	-0.2	1.3	-0.5	-0.3	1.2	0.2
Blood White Count	0.2	1.2	4.9	-0.3	0.8	-0.8	1.0	2.2	-0.1
Heel T-Score	0.4	3.0	12.4	-3.5	-0.9	0.2	-1.2	-0.9	-1.6
BMI	0.4	2.3	4.9	1.1	1.0	0.9	2.2	2.1	-1.1
Height	0.1	2.5	8.2	-1.9	-0.2	-0.8	-1.1	-2.9	-1.2
Waist Hip Ratio (WHR)	0.3	1.5	4.7	-0.4	-2.2	1.4	-0.3	-1.2	-0.9
Systolic Blood Pressure	0.1	0.7	1.3	1.1	1.1	-0.1	-0.9	0.2	1.0
Smoking Status	1.7	4.0	9.6	0.5	1.9	-2.0	-3.1	-1.1	2.3
Allergy or Eczema	0.1	0.4	1.0	-0.9	1.0	0.1	0.5	0.4	-0.3
Cardiovascular Disease	0.0	0.1	0.3	0.5	0.5	-0.2	0.2	-0.2	0.3
Hypothyroidism (self reported)	0.4	0.9	4.1	0.4	0.4	0.6	2.0	0.5	-0.7
Respiratory disease	0.1	0.3	0.6	0.7	0.7	0.2	-0.0	-0.8	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.1	0.0	-0.0	0.3	-0.1	-0.3	-0.3
Lung FEV1/FVC ratio	1.5	7.5	34.7	-5.9	0.5	1.8	2.5	-0.1	-0.8
Lung FVC	0.3	1.4	4.8	2.2	-0.5	-1.2	0.3	1.1	0.9
Neuroticism	0.3	0.8	1.8	0.2	1.3	-1.0	-0.4	1.3	-0.4
Chronotype (morning person)	2.2	5.0	10.3	2.8	1.1	1.8	1.9	3.2	-2.0
Hair Pigment	0.1	2.5	7.1	1.3	0.7	-2.7	1.8	0.8	1.3
Tanning	0.1	0.8	1.7	0.4	0.7	1.3	0.8	1.3	-0.5
Hand grip strength (left)	0.8	2.0	3.5	-1.6	-1.2	1.6	1.4	-0.1	-1.9
Number of treatments/medications taken	1.2	2.1	5.7	0.8	0.5	-2.4	-1.2	-0.7	2.0
Average weekly spirits intake	1.0	1.2	3.7	1.7	0.1	-1.9	0.1	0.3	0.7
Sensitivity / hurt feelings	0.7	1.2	4.0	0.2	2.0	-1.2	-0.7	0.9	0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.7	0.1	-0.0	-0.3	0.6	0.0
Hearing difficulty/problems: Yes	0.5	0.7	2.2	0.5	1.5	-1.2	-0.5	0.2	-0.1
Relative age of first facial hair	1.6	3.3	14.7	-1.0	-1.7	-0.3	-1.0	-3.8	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	0.1	-1.1	-0.4	-0.5	0.1	-0.7
Ever used hormone-replacement therapy (HRT)	1.7	2.2	9.0	0.6	0.2	-0.8	-3.0	-1.7	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	-1.7	0.1	-1.3	-0.5	-0.7	0.6
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.4	0.1	0.6	-0.7	0.3	-0.7
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	5.0	-0.2	1.0	-2.2	-1.8	-1.6	1.4
Angina	0.0	0.0	0.2	0.1	-0.5	0.1	0.1	-0.0	0.1
Medication for hormone replacement therapy	0.3	0.3	1.0	-1.0	-0.1	0.6	0.6	-0.4	-0.2
Vitamin and mineral supplements	0.5	0.6	1.1	-0.7	-0.5	1.1	-0.1	-0.8	-1.1
Supplements: Zinc	0.3	0.3	0.9	-0.2	0.4	-0.4	-0.9	0.7	0.3
Medication: Co-codamol	0.2	0.2	0.5	0.4	0.7	-0.4	0.5	-0.2	0.4
Medication: Metformin	0.1	0.2	1.1	-0.1	0.3	0.1	0.0	-1.1	0.1
Diabetes (father)	0.6	0.8	1.8	-1.4	-1.0	-0.0	1.2	-0.3	0.4
Diabetes (mother)	0.3	0.3	1.1	0.9	0.3	0.1	1.0	0.2	0.2
Severe depression (siblings)	0.3	0.3	1.4	0.6	1.2	0.3	-0.1	0.3	0.3
Pack years adult smoking proportion	0.7	1.0	3.2	-1.8	-0.7	0.2	0.9	-0.1	-1.2
Impedance of leg (right)	0.5	2.5	7.8	-2.8	-0.8	0.2	-1.6	-2.0	-0.3
Leg fat-free mass (left)	0.1	0.6	2.0	0.4	-0.1	0.6	1.4	-0.2	-1.0
Trunk fat percentage	0.3	1.1	2.0	-0.2	1.3	-1.1	1.1	1.4	0.7
Hand grip strength (right)	0.3	0.7	3.2	0.3	-0.6	0.7	1.8	-0.6	-0.2
Townsend deprivation index at recruitment	1.6	2.2	5.8	-0.1	-2.3	-0.8	-1.2	-2.4	-0.4
Current tobacco smoking	1.0	1.6	5.5	-1.9	0.1	-0.7	-2.3	0.3	-0.1
Average weekly fortified wine intake	0.7	0.8	1.9	-1.4	1.4	-0.7	0.2	0.3	0.4
Maternal smoking around birth	0.4	0.6	2.1	-0.8	-1.4	0.7	-0.3	-0.3	-0.3
Fed-up feelings	0.5	0.8	2.5	0.2	0.6	-1.6	-1.4	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	1.1	-0.4	0.4	-0.0	0.2	1.1	0.2
Relative age voice broke	1.0	1.6	4.1	-1.8	-1.3	-0.3	0.8	-2.0	-0.1
Taking other prescription medications	0.5	0.8	1.5	1.2	-0.5	-1.0	-0.9	-0.7	0.8
Age when periods started (menarche)	1.5	3.5	9.4	1.4	-0.9	0.3	-3.1	-3.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.6	0.1	0.8	-1.1	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	0.8	0.7	0.1	0.5	-0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.3	0.4	-1.1	-0.6	-1.5	-0.9	0.2
Qualifications: CSEs or equivalent	0.6	0.8	2.7	-0.4	0.1	1.7	0.1	1.0	-0.9
Serious illness, injury or assault to yourself	1.1	1.3	2.9	0.5	0.0	-1.1	-1.7	-1.2	1.4
High blood pressure	0.1	0.3	0.7	-0.1	-0.8	0.6	0.1	0.4	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.9	-0.2	1.4	-0.8	0.3	0.6	0.6
Multivitamins +/- minerals	0.5	0.6	1.5	-0.4	0.6	-0.3	0.8	1.1	1.2
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	0.4	-0.5	-0.4	0.1	-0.5
Supplements: Glucosamine	2.7	3.6	7.5	1.4	2.7	-1.5	-2.0	0.1	2.3
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.9	1.7	1.2	-0.6	-0.3	0.8	-0.4
Medication: Atenolol	0.7	0.8	2.4	-1.6	0.6	-1.2	0.8	0.4	0.1
Medication: Levothyroxine sodium	0.2	0.4	1.4	1.2	0.1	-0.0	0.5	0.9	-0.1
Sitting height	0.3	2.0	3.4	-0.1	-1.4	0.6	1.7	-1.8	-1.8
Chronic bronchitis/emphysema (father)	1.4	1.7	4.1	1.0	1.2	2.0	1.0	1.5	-0.3
High blood pressure (mother)	1.1	1.5	4.8	1.0	-0.4	-0.0	2.2	1.7	-0.1
Body mass index (BMI)	0.5	2.2	6.4	0.7	0.9	0.3	2.1	2.5	-1.0
Impedance of leg (left)	0.5	2.4	10.1	-3.2	-0.8	-0.0	-1.3	-1.3	-0.6
Leg predicted mass (left)	0.1	0.5	2.0	0.5	-0.0	0.5	1.4	-0.3	-0.9
Trunk fat mass	0.2	1.0	2.5	-0.1	1.2	-0.6	1.6	1.3	0.0
Waist circumference	0.2	0.8	2.2	-0.2	-0.2	0.5	1.5	1.0	-1.2
Number of incorrect matches in round	0.3	0.5	0.9	0.7	0.6	-0.6	0.4	1.0	0.9
Past tobacco smoking	1.9	3.6	7.2	-2.7	-1.7	1.6	1.6	1.1	-2.2
Alcohol usually taken with meals	0.9	1.5	3.8	1.1	0.1	0.6	1.9	1.5	1.0
Nervous feelings	0.5	0.9	3.4	-0.1	1.1	0.7	-0.1	1.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.8	-0.6	0.9	0.3	-0.2	0.8	0.1
Hearing difficulty/problems with background noise	0.3	0.4	0.9	0.3	0.9	-0.4	0.8	0.8	0.4
Hair/balding pattern: Pattern 2	0.7	0.8	1.8	-0.6	0.6	1.2	-0.5	0.9	-1.4
Had menopause	0.7	0.9	3.3	-0.9	0.7	0.4	-0.2	0.5	-1.8
Had other major operations	0.9	1.1	2.8	-0.3	-1.5	0.9	-0.8	-1.7	-0.2
Forced vital capacity (FVC)	0.1	0.3	0.6	0.8	-0.5	-0.2	0.5	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.3	0.6	0.3	0.0	-0.9	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	-0.7	-0.6	0.2	0.3	-0.4	0.2
Qualifications: None of the above	0.6	1.2	2.9	0.2	-0.3	1.3	0.9	1.4	-1.7
Financial difficulties in last 2 years	0.2	0.3	0.8	0.1	0.7	0.4	-0.0	0.9	-0.3
Mouth/teeth dental problems	0.6	0.9	4.5	2.1	0.1	0.3	-0.4	0.8	0.3
Heart attack	0.4	0.5	2.0	-0.4	1.4	-0.7	-0.0	0.2	0.3
Allergy	0.5	1.1	2.5	-0.7	-1.1	1.6	0.1	0.6	-1.5
Pain all over the body in last month	0.7	0.7	2.7	-0.3	1.7	-0.7	-0.1	1.0	-0.3
Diabetes (self-reported)	0.1	0.1	0.2	-0.0	0.5	-0.5	-0.0	-0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	0.6	1.1	-0.4	-0.5	0.2	0.6
Medication: Ramipril	0.4	0.5	1.0	0.6	0.9	-0.0	-0.6	1.0	0.4
Medication: Simvastatin	0.8	1.2	2.0	0.9	1.3	-1.4	0.2	0.9	1.4
Fluid intelligence score	0.2	0.5	1.1	-0.5	-0.5	1.1	0.2	-0.6	-1.0
Illnesses of siblings	0.9	1.3	2.8	-0.5	-1.7	-0.2	-1.2	-1.7	-0.5
Neuroticism score	0.7	1.5	4.3	-0.3	1.4	-2.1	-1.6	0.1	0.7
Weight	0.2	0.9	2.7	0.1	0.6	0.2	1.6	0.8	-1.2
Impedance of arm (right)	1.1	5.2	9.0	-1.6	-0.4	-2.8	-2.6	-2.1	3.0
Arm fat percentage (right)	0.5	1.9	5.6	0.5	1.3	-0.6	1.8	2.4	0.5
Trunk fat-free mass	0.4	2.3	7.0	-0.1	-0.5	1.7	1.7	-0.7	-2.6
Hip circumference	0.2	1.0	2.6	-0.2	1.2	-0.5	1.6	1.3	-0.6
Time employed in main current job	0.3	0.3	0.8	-0.2	0.5	-0.1	-0.7	0.5	0.9
Alcohol intake versus 10 years previously	0.3	0.4	1.6	-0.3	-0.1	0.5	0.3	-1.3	-0.3
Father’s age at death	0.9	1.2	2.7	1.4	-0.7	-0.6	-1.0	-1.6	1.0
Worrier / anxious feelings	0.7	1.3	4.7	-0.0	2.2	-1.2	-0.8	0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.6	-0.5	-1.3	-0.5	0.7	0.6	-0.5
Falls in the last year	1.1	1.5	4.3	-0.6	-1.8	0.1	-0.6	-2.1	-1.0
Hair/balding pattern: Pattern 3	1.1	1.6	5.1	0.8	2.2	-1.0	0.4	1.5	0.6
Number of live births	0.7	1.0	3.1	1.8	-0.3	-0.4	1.4	0.8	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.0	-1.0	0.1	0.2	0.9	-0.7	-0.6
Pulse rate	0.4	0.6	2.0	0.9	-0.0	-0.6	-0.3	1.4	-0.7
Happiness	0.2	0.3	0.6	-0.6	0.2	0.6	-0.4	-0.2	-0.7
Noisy workplace	0.3	0.4	1.5	0.3	1.2	-0.3	-0.1	0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	1.1	-0.6	0.6	0.3	-0.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	0.6	-0.4	-0.9	0.3	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	-1.2	1.2	0.4	-0.5	0.6	-0.6
Asthma	0.6	1.2	2.9	0.6	0.2	-1.4	-1.1	-1.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.0	6.7	-0.2	-1.3	-1.6	-2.6	-2.2	1.4
Medication: Cholesterol lowering	1.5	2.3	3.4	1.3	1.5	-1.1	1.5	1.7	1.8
Depression (self-reported)	0.3	0.4	0.7	-0.2	-0.1	-0.8	0.7	-0.8	0.6
Medication: Lansoprazole	0.6	0.7	2.1	0.5	-1.4	0.4	0.2	0.0	-1.2
Prospective memory result	1.7	2.1	9.7	3.1	0.5	-0.6	0.2	0.6	1.3
Lung cancer (father)	0.2	0.2	0.5	0.3	0.2	-0.5	-0.5	0.7	0.4
Illnesses of mother	0.5	0.7	1.2	-0.5	1.0	0.8	-0.4	0.9	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	-0.9	0.3	0.3	0.9	-0.9	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	1.5	1.2	0.6	-0.3	-0.1	0.1	-0.1
Impedance of arm (left)	1.0	4.8	9.1	-1.2	-0.3	-2.4	-2.7	-2.3	3.0
Arm fat mass (right)	0.5	1.9	5.3	0.4	1.0	-0.0	2.3	2.2	-0.6
Trunk predicted mass	0.4	2.3	7.1	-0.2	-0.6	1.7	1.7	-0.8	-2.7
Standing height	0.3	2.6	11.2	-1.6	-0.6	-0.1	-0.6	-3.3	-1.0
Length of working week for main job	0.9	1.0	2.7	-0.5	-1.0	1.2	1.6	-0.7	-0.7
Exposure to tobacco smoke at home	1.4	1.6	4.0	1.4	-2.0	0.1	-1.6	-1.1	0.1
Breastfed as a baby	1.1	1.3	3.9	0.9	1.3	-0.4	-0.1	1.2	2.0
Tense / ‘highly strung’	0.3	0.5	2.3	-1.5	0.6	-0.1	-0.6	0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.7	-1.3	0.8	-1.0	-0.3	-0.0	-0.4
Hair/balding pattern: Pattern 4	0.4	1.0	4.0	-0.1	-2.0	0.0	1.0	-0.8	0.3
Birth weight of first child	0.7	1.2	3.8	-1.5	-1.9	0.5	0.7	-0.6	0.2
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.7	0.5	0.2	0.8	-0.2	0.1
Pulse wave reflection index	0.7	0.8	3.2	1.8	0.7	0.6	-0.3	0.3	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.8	-0.2	-0.8	-1.7	0.0	0.0	0.6
Loud music exposure frequency	2.4	2.6	7.6	-1.2	-2.8	0.1	-1.2	-2.0	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.8	-0.5	1.4	-1.2	0.1	0.3	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.7	-1.1	-0.2	-1.6	-0.3	-1.3	0.3
Blood clot in the leg (DVT)	0.5	0.7	1.6	0.9	-0.2	-1.1	0.4	-0.3	1.2
Medication: Paracetamol	0.1	0.2	0.6	0.4	-0.2	-0.8	0.1	-0.7	0.1
Headache pain in last month	1.6	2.7	10.4	-1.0	-3.2	1.2	1.3	-0.4	-1.3
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	5.4	-1.5	-1.5	0.6	-1.3	-2.3	-1.5
Glaucoma (self-reported)	0.7	0.8	1.4	-1.2	-1.1	-0.5	-0.5	-1.1	-0.7
Gout (self-reported)	1.5	2.1	4.8	1.6	-1.8	-0.9	-0.3	-1.1	2.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	0.9	0.8	-0.0	1.2	0.9	0.2
Medication: Amlodipine	0.5	0.7	2.7	1.6	0.7	0.2	0.3	0.1	0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	3.9	0.5	0.3	-2.0	-0.4	-0.6	1.2
Birth weight	0.2	0.4	1.3	0.3	-1.1	0.3	0.2	-1.0	-0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.3	-0.9	-1.0	0.9	-0.3	0.6
High blood pressure (siblings)	0.4	0.5	1.6	-0.5	0.3	0.8	0.6	1.3	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.4	1.3	0.8	-0.3	-0.3	0.2	-1.2	0.0
Body fat percentage	0.3	1.3	3.4	-0.2	1.2	-0.7	1.5	1.8	0.3
Leg fat percentage (right)	0.5	1.7	3.8	-0.4	0.9	0.9	1.8	1.9	-1.2
Arm fat-free mass (right)	0.3	1.7	5.3	0.2	-0.2	1.5	1.6	-0.2	-2.3
Exposure to tobacco smoke outside home	2.2	2.9	6.9	-0.0	-2.6	-1.4	-1.8	-2.0	1.3
Comparative body size at age 10	0.7	1.9	5.7	0.8	1.3	-0.3	1.9	2.4	0.0
Number of full brothers	1.3	1.6	2.6	-0.8	-0.8	1.6	1.1	1.6	-1.4
Worry too long after embarrassment	0.6	1.0	2.6	0.2	1.5	-1.6	-0.5	0.4	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.6	-1.6	1.0	-0.4	0.2	0.8	-0.5
Wheeze or whistling in the chest in last year	0.5	0.8	2.4	0.8	0.8	-1.0	-1.6	0.2	0.4
Number of children fathered	0.7	0.8	3.5	0.5	-0.9	0.2	1.9	-0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.0	1.4	1.3	0.1	-0.1	0.8	0.3
Age at first live birth	0.2	0.3	0.9	-1.0	0.3	0.4	0.4	0.4	-0.6
Pulse wave peak to peak time	0.4	0.4	2.0	-1.4	-0.6	0.1	0.1	-0.4	0.2
Health satisfaction	0.3	0.3	0.7	0.4	0.7	-0.4	-0.6	-0.9	0.2
Shortness of breath walking on level ground	0.9	1.0	2.8	0.3	-1.1	1.7	0.7	-0.3	-1.2
Qualifications: College or University degree	0.3	0.9	2.9	0.6	-0.1	1.7	1.2	-0.7	0.4
Eye problems/disorders: None of the above	0.5	0.5	1.1	-1.0	-0.5	0.6	0.6	1.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.2	-0.6	-1.3	0.8	1.8	-0.2	0.1
Emphysema/chronic bronchitis	0.8	0.8	2.1	1.3	-1.5	0.3	-0.4	-1.0	-0.2
Medication for pain relief, constipation, heartburn	1.9	3.2	7.2	0.1	0.8	2.6	2.7	1.6	-1.3
Neck or shoulder pain in last month	0.7	1.0	3.5	-0.5	-1.2	-0.5	-0.7	-1.9	0.4
Medication: Blood pressure	1.3	2.4	4.6	1.9	1.0	-0.9	1.1	2.1	1.7
Angina (self-reported)	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.1	0.0
Migraine (self-reported)	0.4	0.5	1.3	-0.9	-0.7	-0.1	1.1	0.5	0.1
Medication: Ibuprofen	1.2	1.5	3.7	-0.8	-1.5	-0.6	-1.9	-1.3	0.5
Medication: Allopurinol	1.3	1.7	4.7	2.0	-0.7	-0.7	0.2	0.4	2.2
Medication: Omeprazole	0.1	0.2	0.4	0.4	-0.4	-0.1	-0.5	-0.0	-0.6
Medication: Seretide 50 evohaler	0.8	1.0	3.1	1.0	1.0	-1.7	-0.7	-0.3	0.5
Mean time to correctly identify matches	0.9	1.6	3.8	-1.5	-2.0	1.3	0.6	-0.8	-1.0
Heart disease (mother)	0.7	0.8	2.8	1.7	0.8	-0.4	0.8	1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.5	0.5	-0.7	-0.4	-0.7	0.4
Whole body fat mass	0.3	1.3	3.7	-0.0	1.0	0.0	1.9	1.7	-0.4
Leg fat mass (right)	0.4	1.4	3.2	-0.0	1.0	0.7	1.6	1.8	-1.1
Arm predicted mass (right)	0.4	1.9	6.0	0.0	0.1	1.5	1.7	0.1	-2.5
Pulse rate, automated reading	0.3	1.1	2.8	-0.0	-0.4	0.1	-1.0	1.6	-1.7
Alcohol intake frequency.	0.4	1.0	2.2	0.3	0.5	1.5	0.9	1.2	-1.1
Comparative height size at age 10	0.1	0.6	2.3	-0.4	1.5	0.1	0.9	0.4	-0.5
Number of full sisters	0.3	0.4	1.1	-0.4	1.1	-0.1	0.6	0.8	-0.3
Suffer from ‘nerves’	0.7	1.2	3.5	-1.6	0.5	-0.8	-1.9	-0.1	0.2
Overall health rating	0.8	1.7	4.0	0.2	0.9	-2.0	-1.6	-0.5	1.5
Chest pain or discomfort	0.5	0.7	3.3	0.7	0.3	-1.8	0.1	-0.3	0.7
Had major operations	1.5	1.7	5.2	1.1	2.3	-0.5	1.1	1.5	0.7
Age at last live birth	0.3	0.4	1.0	-1.0	-0.0	0.7	0.3	0.2	-1.0
Family relationship satisfaction	0.5	0.6	1.5	0.1	0.7	-0.3	1.2	0.2	1.2
Leg pain on walking	1.4	1.7	3.6	1.9	0.3	-0.1	-1.8	-1.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.9	-0.5	0.1	0.4	1.2	1.2	-1.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	0.4	-0.3	1.1	0.3	-1.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.7	-0.0	0.5	0.1	0.8	0.3	-0.2
Medication: Aspirin	0.1	0.1	0.2	0.3	-0.4	-0.4	0.1	0.2	0.2
Supplements: Vitamin C	0.7	0.8	1.8	1.3	-0.3	0.9	-0.4	0.6	-1.3
Knee pain experienced in last month	0.5	0.8	1.5	0.8	0.6	1.1	-1.2	0.8	-0.5
Hypertension (Self-reported)	0.1	0.2	0.5	-0.0	-0.7	0.2	-0.0	0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	1.5	0.1	-1.2	-0.0	0.4	0.6
Illnesses of father: Heart disease	0.8	1.1	2.5	-0.7	-1.0	0.7	1.2	-1.6	-0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.6	0.4	0.4	0.7	1.2	-0.7
Smoking status: Previous	1.8	2.6	7.4	2.7	1.4	-1.3	-0.3	-1.0	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.5	-1.6	-0.5	0.4	0.4	-2.1	0.0
Whole body fat-free mass	0.3	1.4	4.1	0.1	-0.2	1.2	1.7	-0.4	-2.0
Leg fat-free mass (right)	0.1	0.6	2.3	0.4	0.0	0.3	1.5	0.1	-0.9
Arm fat percentage (left)	0.5	1.8	5.1	0.8	1.3	-0.5	1.7	2.3	0.6
Average weekly red wine intake	0.2	0.4	1.0	-0.2	-1.0	0.3	-0.0	-0.7	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.9	0.1	-1.4	-0.6	-0.0	-0.4	-0.2
Mood swings	0.6	1.1	3.4	0.2	1.8	-1.4	-0.6	0.6	0.7
Loneliness, isolation	0.3	0.4	0.9	-0.6	-0.6	0.5	-0.6	1.0	-0.4
Long-standing illness, disability or infirmity	1.1	1.7	3.8	1.2	0.5	-1.8	-0.7	-1.9	1.1
Ever had bowel cancer screening	1.5	1.7	4.8	1.1	-0.2	-2.2	-1.9	-0.3	0.5
Diabetes diagnosed by doctor	0.0	0.0	0.1	0.1	0.3	0.1	0.2	-0.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.2	0.4	-0.6	-0.7	1.1	-0.7	0.1
Friendships satisfaction	0.9	1.1	4.2	0.4	0.8	0.9	2.1	0.9	-0.2
Qualifications: nursing, teaching	1.5	2.3	4.5	1.4	0.5	-1.2	-2.1	-1.1	2.1
Commuting to job workplace: Walk	0.6	0.6	2.3	-1.5	-0.6	-0.5	-0.7	0.5	-0.0
Eye problems/disorders: Cataract	0.5	0.6	1.7	1.2	1.3	0.3	-0.5	-0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.5	0.1	-0.7	0.5	0.1	0.4
Medication for cholesterol	0.4	0.6	1.4	1.2	0.4	-0.0	-0.8	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.2	-1.8	0.4	-0.9	-0.7	-0.5	0.3
Back pain experienced in last month	0.9	1.3	3.3	-0.6	-1.8	-1.4	-0.5	-1.4	-0.1
Mineral and other dietary supplements	0.6	0.9	3.9	0.3	-2.0	-0.0	0.9	-0.1	-0.7
Breast cancer (self-reported)	0.4	0.5	2.7	0.1	-0.4	1.6	-0.4	-0.1	-0.0
Asthma (self-reported)	0.3	0.7	1.8	0.3	0.4	-0.9	-0.9	-1.3	0.7
Osteoporosis (self-reported)	2.3	2.9	7.3	-0.4	0.9	2.4	0.5	1.8	-2.7
Osteoarthritis (self-reported)	0.5	0.6	1.7	-0.9	0.6	-0.7	-1.3	-0.5	0.3
Medication: Aspirin	0.1	0.1	0.3	0.6	-0.0	-0.2	0.1	0.3	0.1
Medication: Gliclazide	0.6	0.6	1.6	0.8	0.8	0.2	-0.8	0.5	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	2.6	-0.2	0.0	-0.8	-1.6	0.9	0.2
Smoking status: Current	1.1	1.7	7.2	-1.6	-0.0	-0.7	-2.7	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	5.5	-0.1	-0.5	2.3	1.4	0.5	-1.3
Whole body water mass	0.2	1.4	4.0	-0.0	-0.3	1.1	1.7	-0.4	-2.0
Leg predicted mass (right)	0.1	0.5	2.1	0.4	-0.1	0.2	1.4	0.0	-0.9
Arm fat mass (left)	0.5	1.9	5.6	0.5	1.2	0.1	2.4	2.0	-0.5
Number of self-reported non-cancer illnesses	1.5	2.6	4.2	-0.4	-0.7	-2.1	-1.9	-2.0	1.7
Average weekly champagne plus white wine intake	1.3	1.9	5.1	-0.1	-1.6	-2.3	-0.8	-1.0	1.3
Miserableness	1.5	2.5	9.1	-0.8	0.2	-3.0	-1.7	-1.3	0.9
Guilty feelings	0.0	0.0	0.2	0.1	-0.5	0.0	-0.0	0.0	0.0
Wears glasses or contact lenses	0.6	0.7	2.2	0.9	1.5	0.3	0.5	-0.3	0.7
Ever taken oral contraceptive pill	0.9	1.0	1.7	1.0	0.0	-1.3	1.1	-0.7	1.3
Hearing aid user	1.8	2.0	3.0	1.5	1.7	-1.7	0.1	1.4	1.3
Mother’s age at death	2.3	2.8	5.8	0.8	-0.1	-2.1	-1.2	-2.2	2.4
Financial situation satisfaction	0.9	1.1	2.8	1.1	1.2	-0.9	0.4	0.1	1.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.7	0.6	1.0	0.5	0.1	0.0
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.9	0.3	-0.9	0.0	1.0	0.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	0.3	-0.8	-0.4	-0.5	-0.8	-0.3
Medication: Blood pressure	1.3	2.4	5.8	-1.8	-1.7	1.0	0.4	-1.3	-2.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	-0.3	0.0	0.8	0.3	0.6	-0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.7	-0.5	1.6	1.1	-0.4	-0.6	0.7
High cholesterol (Self-reported)	0.8	1.5	4.2	-0.9	-0.0	-2.0	-0.6	-1.0	1.6
Medication: Bendroflumethiazide	0.3	0.5	1.4	0.1	-0.6	-1.2	0.2	0.2	1.0
Medication: Paracetamol	0.1	0.2	0.7	-0.3	-0.1	0.1	0.7	0.0	-0.8
Medication: Lisinopril	0.1	0.1	0.4	0.0	-0.5	-0.6	-0.2	0.4	-0.2
Medication: Atorvastatin	0.5	0.7	1.1	-0.1	-0.9	-1.0	1.0	-0.6	0.8
Illnesses of father: High blood pressure	0.6	0.7	2.7	-1.6	-0.2	0.4	1.1	0.4	-0.3
Alcohol drinker status: Never	0.5	0.6	2.1	-0.3	1.1	-0.1	-0.3	1.4	-0.2
Ever smoked	2.8	5.0	8.2	2.6	2.2	-2.1	-2.2	-0.6	2.9
Basal metabolic rate	0.2	1.4	3.9	-0.1	-0.1	1.0	1.8	-0.1	-2.0
Leg fat percentage (left)	0.7	2.4	5.8	-0.6	0.9	0.8	2.2	2.4	-1.4
Arm fat-free mass (left)	0.5	2.5	7.6	-0.6	-0.2	1.6	2.1	-0.1	-2.8
Number of operations (self-reported)	0.7	1.0	2.5	1.1	0.2	-0.7	-1.0	-0.9	1.6
Average weekly beer plus cider intake	0.7	1.0	3.4	-0.8	-0.4	1.4	0.2	-0.2	-1.8
Irritability	1.2	2.0	4.4	0.3	1.7	-2.1	-1.0	-1.0	1.7
Risk taking	1.5	2.2	7.1	-1.7	-2.7	1.1	0.3	-0.1	-1.4
Ever had prostate specific antigen (PSA) test	1.4	1.6	5.3	1.5	2.3	-0.4	-0.1	1.2	0.5
Fractured/broken bones in last 5 years	0.4	0.6	2.1	0.4	-0.1	-0.6	-1.5	-0.8	-0.2
Age started oral contraceptive pill	1.2	1.5	3.0	-1.2	-1.6	1.2	0.2	-0.7	-1.7
Diastolic blood pressure, automated reading	0.3	0.9	2.7	0.4	-0.6	1.6	-0.2	0.2	-1.5
Ever depressed for a whole week	1.2	1.4	2.5	-1.2	-1.6	1.2	1.3	0.4	-1.2
Unable to work because of sickness or disability	0.8	1.0	2.1	-0.2	1.3	1.5	0.1	0.9	-1.1
Commuting to job workplace: Cycle	0.5	0.6	1.0	0.8	-1.0	0.9	-0.8	-0.9	-0.3
Myopia	0.6	0.9	2.0	1.0	1.4	-1.0	-0.5	0.6	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.4	0.5	-0.9	-0.6	-0.9	1.0
Cholesterol lowering medication	0.4	0.5	2.0	-0.7	-0.5	-0.5	-0.5	-1.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	0.0	-1.1	-0.6	-1.2	-1.1	-0.3
Pain experienced in last month	0.3	0.5	0.9	0.2	0.8	0.9	1.0	0.8	-0.2
Supplements: Calcium	0.5	0.6	2.3	-0.2	1.5	0.3	-0.7	0.7	0.1
Basal cell carcinoma (self-reported)	2.0	2.3	9.7	-0.1	-0.7	-3.1	-1.4	-0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	-0.5	1.5	-0.3	0.4	0.6	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	0.7	-0.4	-0.9	0.0	-0.6	1.0
Heart disease (siblings)	0.3	0.3	1.3	-0.1	0.2	-0.3	0.2	1.1	-0.7
Alcohol drinker status: Previous	1.4	1.5	4.6	2.1	0.4	0.8	1.6	1.0	0.4
Pack years of smoking	0.7	1.0	2.6	-1.3	-0.7	0.6	1.0	0.2	-1.6
Impedance of whole body	0.7	3.6	5.3	-2.3	-0.5	-1.7	-2.3	-2.2	1.8
Leg fat mass (left)	0.4	1.7	4.0	-0.4	1.0	0.6	1.8	2.0	-1.2
Arm predicted mass (left)	0.4	2.0	6.6	-0.3	-0.2	1.3	1.9	-0.4	-2.6