TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Lung FEV1/FVC ratio
:
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chr6:6,701,209-8,352,004
Best TWAS P=1.46e-27 · Best GWAS P=1.7e-49 conditioned to 6.77e-50
6.8M
7M
7.2M
7.4M
7.6M
7.8M
8M
8.2M
8.4M
0
10
20
30
40
50
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Lung
DSP
0.33
0.23
lasso
4
0.23
1.9e-17
10.8
-10.9
1.5e-27
-0.02
1.00
0.00
TRUE
1
GTEx
Brain Hippocampus
RIOK1
0.39
-0.01
enet
47
0.01
1.9e-01
-5.9
-6.6
4.6e-11
-0.01
0.08
0.09
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
EEF1E1
0.06
0.03
blup
65
0.04
1.0e-05
-5.7
6.3
3.7e-10
-0.04
0.05
0.95
TRUE