TWAS hub - EEF1E1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3100	0.0900	6.3e-04	0.191	NA	0.170	NA	0.160	2.6e-06	NA	1.0e-05	NA	1.8e-05
2	GTEx	Skin Not Sun Exposed Suprapubic	0.2320	0.0670	7.1e-05	0.011	NA	0.073	NA	0.049	7.9e-02	NA	7.5e-05	NA	1.1e-03
3	YFS	Blood	0.0107	0.0058	2.8e-02	0.011	0.001	0.005	0.002	0.007	1.0e-04	9.0e-02	9.6e-03	0.069	2.1e-03
4	TCGA	Breast Invasive Carcinoma	0.0254	0.0120	7.3e-05	0.029	0.017	0.020	NA	0.022	9.5e-07	1.8e-04	4.8e-05	NA	2.2e-05
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0709	0.0329	5.4e-04	0.001	0.021	0.014	NA	0.008	2.7e-01	2.0e-03	8.3e-03	NA	3.7e-02
6	TCGA	Liver Hepatocellular Carcinoma	0.1740	0.0950	3.8e-03	0.077	0.041	0.085	NA	0.032	1.7e-04	5.1e-03	8.5e-05	NA	1.2e-02
7	TCGA	Lung Adenocarcinoma	0.0611	0.0277	1.7e-06	0.031	0.042	0.027	NA	0.037	1.5e-04	1.0e-05	3.9e-04	NA	3.4e-05
8	TCGA	Lung Squamous Cell Carcinoma	0.0572	0.0322	1.6e-03	0.022	0.012	0.024	NA	0.016	1.4e-03	1.3e-02	7.9e-04	NA	5.4e-03
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0490	0.0300	6.0e-03	0.040	0.008	0.001	NA	0.030	9.9e-04	9.0e-02	2.6e-01	NA	3.9e-03
10	TCGA	Prostate Adenocarcinoma	0.0713	0.0285	2.5e-06	0.076	0.058	0.065	NA	0.068	2.5e-08	9.7e-07	2.3e-07	NA	1.2e-07
11	TCGA	Stomach Adenocarcinoma	0.0370	0.0220	8.6e-03	0.045	0.014	0.017	NA	0.026	3.5e-04	3.0e-02	2.0e-02	NA	5.2e-03
12	TCGA	Thyroid Carcinoma	0.0680	0.0320	4.1e-03	0.035	0.024	0.028	NA	0.026	2.1e-04	2.0e-03	9.1e-04	NA	1.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Age started oral contraceptive pill	5.7	7.2	9.7	-0.3	2.6	3.1	2.8	3.0	2.9	2.5	2.0	3.1	3.0	3.1	2.4
Guilty feelings	4.7	7.1	12.8	2.6	3.0	2.3	2.1	3.3	1.7	2.6	3.6	3.0	2.4	2.3	2.4
Unable to work because of sickness or disability	4.5	5.8	13.6	0.2	-2.0	-2.8	-3.3	-2.0	0.0	-3.7	-1.6	-3.1	-2.8	-2.8	-1.2
Commuting to job workplace: Public transport	3.6	4.3	6.8	0.3	1.9	2.2	2.5	2.4	1.3	2.3	2.2	2.1	2.1	2.6	2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	15.2	0.0	1.3	3.6	3.9	2.0	0.0	2.5	1.8	3.1	3.6	3.7	3.0
Length of working week for main job	3.4	3.7	6.4	-1.8	-2.2	-2.2	-2.5	-1.0	-0.3	-1.7	-2.3	-1.9	-2.2	-2.3	-1.5
Commuting to job workplace: Walk	3.4	3.7	6.9	0.2	1.6	2.3	2.3	1.8	-0.9	2.2	1.7	1.9	2.3	2.0	2.6
Commuting to job workplace: Car/motor vehicle	3.3	3.7	7.0	-1.2	-1.6	-2.0	-1.8	-2.6	-1.2	-1.8	-2.1	-1.9	-2.0	-1.8	-2.6
Maternal smoking around birth	3.2	4.7	9.3	-0.1	-2.5	-2.5	-2.5	-2.6	-2.1	-1.0	-1.1	-2.1	-2.5	-3.0	-1.9
Ever smoked	3.0	5.3	9.0	3.0	1.7	2.4	2.0	2.8	2.0	1.9	2.0	2.7	2.5	2.4	1.7
Pack years adult smoking proportion	2.9	4.5	8.6	-0.2	-2.9	-2.1	-2.8	-2.3	-1.4	-1.8	-1.5	-2.1	-2.1	-2.8	-1.6
Supplements: Zinc	2.7	3.0	8.8	-0.3	1.0	2.0	2.3	1.1	0.6	3.0	0.7	2.4	1.9	2.2	-0.0
Chronic bronchitis/emphysema (mother)	2.7	3.2	5.5	2.0	-2.0	-2.0	-2.2	-1.3	-1.3	-2.1	-0.1	-2.0	-2.0	-2.3	-0.6
Medication: Metformin	2.6	3.7	7.7	0.7	-1.8	-2.5	-2.5	-1.8	-0.1	-1.2	0.1	-2.0	-2.4	-2.8	-2.4
Serious illness, injury or assault to yourself	2.6	3.1	5.6	0.2	-1.3	-2.2	-2.4	-1.2	-0.1	-2.3	-2.1	-2.1	-2.2	-2.1	-1.0
Pack years of smoking	2.6	3.9	7.5	0.1	-2.7	-2.0	-2.6	-2.2	-1.0	-1.7	-1.5	-2.0	-2.0	-2.6	-1.6
Medication: Atorvastatin	2.5	3.2	6.8	1.2	-1.3	-1.7	-1.5	-2.2	-1.0	-1.5	-2.6	-1.8	-1.7	-1.3	-2.5
Lung FEV1/FVC ratio	2.4	12.1	39.3	-1.0	1.8	3.8	4.2	2.6	1.0	6.3	3.8	4.8	3.5	3.5	0.8
Medication for hormone replacement therapy	2.4	2.7	6.5	0.8	-1.7	-1.6	-1.4	-2.5	-0.8	-2.2	-1.4	-1.9	-1.6	-1.8	-0.7
Diabetes (self-reported)	2.4	3.7	7.1	-0.6	-1.9	-2.3	-2.1	-2.5	-0.9	-1.6	-0.4	-2.3	-2.3	-2.7	-1.8
Number of full sisters	2.4	2.9	8.4	1.8	-0.4	1.7	1.0	2.9	1.1	1.1	1.9	1.4	1.8	1.6	2.2
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	4.8	0.3	-0.7	-2.2	-2.2	-0.9	-0.2	-1.6	-1.1	-1.8	-2.2	-2.2	-1.4
Father’s age at death	2.3	3.1	8.6	-1.2	1.4	1.9	1.4	2.3	-0.1	1.4	1.8	1.7	2.1	1.2	2.9
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	6.0	-0.2	-2.3	-1.9	-1.3	-2.5	0.3	-1.7	-1.2	-1.7	-1.9	-1.6	-2.2
Average weekly beer plus cider intake	2.2	3.2	6.2	-1.4	-2.5	-2.2	-2.3	-1.3	-1.0	-1.3	-0.0	-2.0	-2.1	-2.2	-1.5
Diastolic blood pressure, automated reading	2.2	6.8	14.7	1.7	2.3	2.4	2.4	3.4	3.8	1.8	2.4	2.6	2.4	3.0	2.2
Medication: Lansoprazole	1.8	2.1	3.4	-1.7	-1.9	-1.4	-1.7	-0.9	-1.4	-0.9	-1.8	-1.0	-1.2	-1.7	-1.3
Tense / ‘highly strung’	1.8	2.9	6.6	2.3	1.8	0.9	0.7	2.4	2.6	0.6	2.4	1.4	1.1	1.2	1.5
Worry too long after embarrassment	1.8	3.0	5.5	1.0	1.3	1.6	1.5	2.3	-0.1	2.3	2.0	2.2	1.7	1.8	1.5
Emphysema/chronic bronchitis	1.8	2.0	3.8	-0.1	-1.2	-1.9	-1.9	-0.8	-1.1	-1.2	-1.1	-1.6	-1.9	-1.9	-1.1
Smoking status: Previous	1.8	2.8	4.5	1.5	0.5	1.6	1.7	2.1	1.8	1.7	1.9	2.1	1.6	2.0	0.6
Diabetes diagnosed by doctor	1.8	3.0	5.9	0.5	-1.9	-2.1	-1.9	-2.1	-0.8	-1.5	-0.1	-1.9	-2.0	-2.4	-1.6
Ever taken oral contraceptive pill	1.8	2.0	4.7	1.2	2.2	1.1	1.2	2.0	1.5	1.2	1.2	1.7	1.3	1.4	0.4
Type 2 Diabetes (T2D) (2018)	1.7	3.2	5.8	-0.8	-2.3	-2.0	-1.8	-1.9	-2.0	-1.0	-0.6	-2.0	-2.0	-2.4	-1.4
Past tobacco smoking	1.7	3.1	5.4	-2.3	-0.6	-1.7	-1.6	-2.2	-1.4	-1.7	-2.0	-2.1	-1.8	-1.8	-1.1
Wheeze or whistling in the chest in last year	1.7	3.0	5.9	2.4	-0.5	-2.4	-2.3	-0.8	-0.3	-1.3	0.3	-1.6	-2.3	-2.3	-1.9
Alzheimer’s Disease (in mother)	1.6	1.9	3.0	0.4	-0.7	1.7	1.5	1.4	0.8	1.5	0.8	1.6	1.7	1.6	1.7
Major Depression (MDD)	1.5	1.8	3.9	1.3	-0.2	-1.5	-1.7	-0.4	-2.0	-1.3	0.0	-1.7	-1.4	-2.0	0.0
Type 2 Diabetes (T2D) (2012)	1.5	1.7	5.4	0.1	1.0	1.4	1.5	0.6	-0.8	1.6	2.3	1.3	1.6	0.6	1.5
Ovarian Cancer	1.4	1.9	6.6	0.6	0.7	-1.2	-1.1	-1.8	-0.3	-1.3	-2.6	-1.3	-1.3	-1.2	-1.8
Age when periods started (menarche)	1.4	3.2	6.6	0.8	-2.5	-2.0	-2.5	-1.3	-0.9	-1.6	-0.9	-1.9	-2.1	-2.6	-1.0
Eye problems/disorders: None of the above	1.4	1.6	3.4	0.7	-0.8	-1.4	-1.1	-1.8	-1.2	-1.5	-1.1	-1.6	-1.3	-1.2	-1.2
Illnesses of siblings: Diabetes	1.4	1.8	2.8	1.6	-0.4	-1.5	-1.7	-1.1	-0.2	-1.6	-1.0	-1.5	-1.4	-1.6	-1.2
Pain experienced in last month	1.4	2.3	5.2	-0.5	2.0	1.4	1.4	1.6	2.3	1.1	-1.2	1.5	1.4	1.8	0.7
Alcohol usually taken with meals	1.3	2.2	5.9	0.1	1.2	1.5	1.7	1.8	2.4	0.9	-0.7	1.5	1.5	2.0	0.8
Medication: Ventolin 100micrograms inhaler	1.3	1.7	5.0	-0.9	0.4	1.4	1.7	0.4	-0.2	2.2	1.6	1.6	1.4	1.3	0.6
Supplements: Vitamin C	1.3	1.6	2.8	1.6	0.5	1.5	1.0	1.2	1.5	1.2	0.3	1.4	1.7	1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	6.8	2.6	1.0	-1.6	-1.8	-0.3	0.1	-1.9	-0.3	-1.3	-1.5	-1.4	-1.1
Eye problems/disorders: Glaucoma	1.3	1.5	2.9	-1.1	-0.1	1.4	1.0	1.3	0.2	1.6	1.7	1.3	1.3	1.1	1.5
Reaction Time	1.2	2.2	6.2	-0.3	-1.2	-1.7	-2.0	-1.2	0.6	-2.5	0.4	-2.0	-1.6	-1.9	0.1
Chronotype (morning person)	1.2	2.8	8.0	1.8	0.6	1.6	1.1	2.8	2.5	0.5	0.8	1.4	1.6	2.0	1.7
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.3	-0.5	-1.5	-1.2	-1.1	-1.7	1.0	-1.8	-0.6	-1.4	-1.4	-0.9	-1.1
Qualifications: CSEs or equivalent	1.2	1.6	4.4	-0.1	-1.1	-1.2	-1.3	-0.7	-2.0	-1.0	-2.1	-1.2	-1.2	-1.5	-0.7
Stomach or abdominal pain in last month	1.2	1.4	3.5	-0.9	-1.9	-1.0	-1.0	-1.6	-1.8	-0.8	-0.7	-1.2	-1.0	-1.2	-0.6
Number of incorrect matches in round	1.2	2.1	5.0	0.1	-0.1	1.6	1.7	1.3	0.1	1.4	1.9	1.5	1.5	1.5	2.2
Had menopause	1.2	1.5	2.7	-0.5	0.7	1.4	1.4	0.6	1.6	0.8	1.6	1.5	1.3	1.4	1.0
Medication: Ramipril	1.2	1.5	7.3	0.7	-1.0	1.2	0.9	0.5	2.7	1.3	-0.3	1.4	0.9	1.4	-0.0
Noisy workplace	1.2	1.5	4.3	1.0	-0.4	-1.6	-2.1	0.0	-0.3	-1.0	-0.1	-1.2	-1.6	-1.8	-1.0
Comparative height size at age 10	1.2	6.4	10.4	1.2	1.6	2.9	2.8	2.5	2.9	2.2	1.6	3.1	2.9	3.2	2.3
Age at last live birth	1.2	1.8	5.0	1.6	1.0	1.2	1.5	0.9	2.2	1.6	0.3	1.5	1.2	1.4	-0.2
Leg pain on walking	1.2	1.5	3.3	0.0	1.3	1.1	1.4	1.6	0.4	1.1	1.8	1.4	1.1	1.5	1.0
Age at First Birth	1.1	1.7	3.2	0.9	1.0	1.1	1.6	0.5	1.7	1.6	-0.6	1.7	1.1	1.8	-1.1
Diabetes (father)	1.1	1.3	3.8	-1.7	0.7	-0.8	-0.8	-1.3	0.3	-1.9	-1.6	-1.5	-0.7	-0.8	0.1
Breastfed as a baby	1.1	1.4	3.1	0.1	0.7	1.5	1.7	0.8	0.5	1.2	0.5	1.3	1.4	1.8	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.7	0.6	-0.8	-1.7	-1.1	-1.1	-1.9	0.2	0.4	-1.1	-1.7	-1.8	-1.3
Medication: Amlodipine	1.1	1.5	2.9	0.6	-1.2	-1.2	-1.0	-1.5	-0.1	-1.7	-1.5	-1.3	-1.3	-1.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	4.7	0.2	-2.2	-1.1	-0.7	-1.4	-0.9	-1.0	-1.2	-1.1	-1.1	-0.7	-1.0
Qualifications: nursing, teaching	1.1	1.8	4.8	-0.3	-0.3	-1.7	-1.2	-1.4	0.3	-1.6	-1.2	-1.3	-1.7	-1.2	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.6	-0.0	-1.6	-1.0	-1.2	-1.1	0.5	-1.6	-1.6	-1.2	-1.0	-1.0	-0.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.3	0.8	-1.4	-1.5	-1.2	-0.4	0.9	-1.1	-0.9	-1.1	-1.4	-1.2	-1.2
Supplements: Calcium	1.1	1.2	5.5	-1.1	-0.5	-1.1	-0.8	-1.1	0.4	-0.2	-1.6	-0.5	-1.2	-0.6	-2.3
Basal cell carcinoma (self-reported)	1.1	1.3	3.7	-0.0	-1.2	-1.1	-1.1	-1.6	-1.9	0.0	-0.3	-1.0	-1.2	-1.3	-0.9
Hand grip strength (right)	1.0	2.6	5.4	0.1	1.4	1.9	1.8	2.1	0.4	2.3	0.3	2.2	1.8	1.9	1.0
Hip circumference	1.0	4.5	7.5	0.2	1.8	2.5	2.2	2.1	1.2	2.5	2.2	2.7	2.4	2.1	2.1
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	5.9	2.4	-1.0	-1.4	-1.3	-0.5	-1.1	-0.5	0.8	-1.1	-1.4	-1.6	-0.6
Illnesses of mother	1.0	1.2	3.5	1.4	1.0	0.9	1.0	0.5	-0.8	0.0	1.7	0.6	1.1	0.8	1.9
Pulse wave reflection index	1.0	1.2	7.7	0.5	-2.8	-0.2	-0.2	-1.9	-0.5	-0.6	-1.1	-0.8	-0.2	-0.4	-0.7
Medication: Allopurinol	1.0	1.3	6.1	-0.8	-1.4	-0.4	-0.6	-1.4	-1.0	-0.5	-2.5	-1.0	-0.5	-0.6	-1.1
Medication: Seretide 50 evohaler	1.0	1.1	5.4	-2.3	-0.9	-1.0	-0.8	-0.6	-1.0	-0.1	-0.9	-0.7	-1.1	-0.6	-1.2
Back pain experienced in last month	1.0	1.4	3.5	0.6	-1.8	-1.1	-1.0	-1.4	-1.9	-1.4	-0.3	-1.3	-1.1	-1.0	-0.4
Number of self-reported non-cancer illnesses	1.0	1.8	5.4	-0.6	-2.3	-1.3	-0.8	-2.0	-0.6	-1.1	0.7	-1.4	-1.3	-1.2	-1.5
Financial situation satisfaction	1.0	1.2	3.1	0.4	-0.6	-1.4	-1.8	0.4	-1.2	-1.0	-0.6	-1.2	-1.4	-1.4	-0.1
Ever depressed for a whole week	1.0	1.2	8.9	0.8	-0.9	-0.8	-0.7	-0.5	-3.0	-0.2	0.1	-0.9	-0.8	-1.1	0.2
Supplements: Glucosamine	0.9	1.2	5.6	-1.2	-0.4	0.6	0.7	-0.4	-1.3	1.8	2.4	1.0	0.6	-0.0	0.3
Had other major operations	0.9	1.0	3.0	-0.1	0.7	1.2	1.4	0.4	1.7	0.2	0.3	1.1	1.2	1.4	0.9
Illnesses of siblings	0.9	1.3	7.3	-1.1	1.6	0.5	0.5	0.8	-2.7	1.4	0.4	0.6	0.6	0.1	0.9
Pulse wave Arterial Stiffness index	0.9	1.0	5.1	1.4	-2.3	-0.3	-0.3	-0.3	1.7	-0.9	0.8	-0.5	-0.3	-0.4	0.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	6.6	-0.8	-1.4	-0.6	-1.0	-0.4	-2.6	0.3	0.8	-0.6	-0.6	-1.1	0.3
Number of full brothers	0.9	1.1	2.4	-1.0	-0.5	1.4	1.6	0.4	1.0	1.1	0.2	1.4	1.2	1.6	0.4
Pulse wave peak to peak time	0.9	1.1	5.0	-1.5	2.2	0.3	0.4	0.5	-1.7	1.0	-0.6	0.6	0.4	0.4	-0.3
Health satisfaction	0.9	1.2	5.9	1.0	1.1	0.5	0.3	2.4	-0.1	1.1	0.9	0.9	0.4	0.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	4.4	2.1	-0.1	0.4	0.2	1.6	1.0	0.2	1.5	0.8	0.5	0.4	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	3.3	1.8	-0.5	-1.1	-0.9	-0.1	1.3	-1.1	0.2	-0.7	-1.0	-0.8	-0.5
Medication: Blood pressure	0.9	1.6	2.5	-0.7	-0.2	1.5	1.4	0.8	1.6	1.5	1.6	1.5	1.3	1.5	0.6
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.3	-1.8	0.5	1.0	0.7	1.1	1.0	0.6	1.6	0.9	0.9	0.8	1.4
Lung cancer (father)	0.8	0.9	4.5	-0.3	1.9	0.6	-0.1	2.1	0.8	0.7	0.2	0.7	0.6	0.6	0.7
Birth weight of first child	0.8	1.4	4.0	2.0	0.1	-0.9	-1.0	-0.2	1.6	-2.0	-1.4	-0.9	-0.8	-0.3	-1.0
Heart disease (mother)	0.8	1.0	1.6	0.2	-1.3	-1.2	-1.3	-1.0	-0.0	-1.0	-0.7	-1.0	-1.2	-1.1	-1.1
Overall health rating	0.8	1.7	3.7	0.4	-1.9	-1.5	-1.6	-0.8	-0.6	-1.4	-0.7	-1.6	-1.6	-1.5	-0.3
Medication: Aspirin	0.8	1.0	2.2	-0.4	-0.9	-1.0	-1.0	-1.4	0.8	-1.5	-0.5	-0.8	-0.9	-0.8	-1.5
Knee pain experienced in last month	0.8	1.3	5.7	-1.0	-1.3	0.5	0.6	-0.6	-2.4	0.7	2.1	0.6	0.5	-0.2	0.8
Long-standing illness, disability or infirmity	0.8	1.2	4.0	-0.4	-1.8	-0.9	-0.5	-2.0	-0.1	-0.9	-1.3	-1.0	-1.0	-0.7	-1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	5.5	-2.3	-0.8	-0.3	-0.7	-1.0	-1.3	0.5	-0.6	-0.3	-0.3	-0.8	-1.2
Miserableness	0.8	1.3	4.7	0.1	-1.1	-1.4	-1.4	-0.6	-2.2	0.1	-0.0	-1.0	-1.4	-1.5	-0.5
Depressed Affect (Nagel 2018)	0.7	1.4	3.2	0.7	-0.3	-1.6	-1.7	-0.7	-1.6	-0.6	-0.3	-1.3	-1.5	-1.8	-0.5
Ulcerative Colitis (UC)	0.7	1.4	4.2	-2.1	-1.8	-0.7	-0.8	-1.2	-1.4	-0.6	-1.2	-0.7	-0.7	-0.8	-0.8
HbA1C	0.7	0.8	2.3	1.5	-0.3	-1.0	-0.9	-0.1	0.6	-0.7	-0.6	-0.6	-1.0	-0.5	-1.4
Triglycerides	0.7	1.1	2.2	0.7	0.6	0.9	1.3	0.8	1.2	1.3	-1.1	1.3	0.9	1.5	-0.7
Heel T-Score	0.7	5.8	9.9	2.2	-3.1	-3.0	-2.8	-2.2	-0.1	-2.2	-0.7	-2.4	-2.8	-2.6	-2.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.3	1.4	1.1	0.4	0.1	1.7	0.4	0.7	1.8	0.6	0.4	0.3	1.2
Fed-up feelings	0.7	1.2	2.7	1.1	0.2	-1.2	-1.5	-1.0	-1.4	-0.7	0.4	-1.3	-1.2	-1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	0.4	0.7	1.0	1.1	1.1	0.5	0.4	-0.5	1.0	1.0	1.3	1.0
Hair/balding pattern: Pattern 2	0.7	0.8	3.8	-0.1	-2.0	-0.9	-1.2	0.3	-0.4	-0.3	-0.4	-0.7	-0.9	-0.9	-1.0
Qualifications: None of the above	0.7	1.4	4.2	0.5	-1.0	-1.4	-1.9	-0.5	-0.5	-1.5	-0.2	-1.5	-1.2	-2.1	0.0
Leg fat percentage (right)	0.7	2.5	5.5	-0.7	0.0	1.8	1.9	1.0	0.5	2.4	2.0	2.0	1.7	1.4	1.8
Comparative body size at age 10	0.7	1.9	5.8	2.4	1.0	1.0	0.5	1.4	0.0	-0.0	2.3	0.8	1.1	0.6	2.3
Medication: Blood pressure	0.7	1.2	2.6	-1.3	-1.6	-0.9	-0.7	-1.0	1.1	-1.4	-1.4	-0.9	-0.9	-0.6	-1.0
Illnesses of father: Heart disease	0.7	1.0	2.2	-0.1	1.4	1.1	1.4	0.3	1.3	0.6	-0.3	1.1	1.0	1.5	-0.3
Mood swings	0.7	1.3	2.9	-0.4	-0.2	-1.7	-1.6	-0.6	-1.3	-0.4	0.1	-1.3	-1.6	-1.7	-0.9
Medication: Gliclazide	0.7	0.8	5.9	2.4	0.6	0.2	0.1	0.3	0.6	0.0	1.2	0.2	0.2	0.0	0.9
Medication: Lisinopril	0.7	0.9	3.1	-1.3	0.2	0.8	0.6	1.8	0.5	0.8	1.3	0.9	0.9	0.7	0.7
Leg fat mass (left)	0.7	2.6	6.0	-0.1	0.0	1.9	1.7	1.3	0.2	2.4	2.1	2.1	1.8	1.3	2.0
Bipolar Disorder (2018)	0.6	1.0	3.9	-0.4	-2.0	-1.0	-1.0	0.1	1.0	0.4	-0.1	-0.8	-1.1	-0.8	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	0.5	1.1	1.1	1.0	0.4	-0.6	1.0	-0.2	1.2	1.2	0.9	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.3	-0.4	1.1	0.7	1.5	0.5	1.1	0.3	1.2	1.1	1.0	1.4
Coronary Artery Disease (CAD)	0.6	0.7	2.5	0.9	-1.2	-0.8	-0.7	-0.2	1.1	-0.8	-0.8	-0.1	-0.7	-0.2	-1.6
Smoking Status	0.6	1.3	10.3	3.2	0.0	0.4	0.2	1.3	1.4	0.3	0.8	0.7	0.4	0.6	0.4
Taking other prescription medications	0.6	1.0	5.7	-1.5	-2.4	-0.7	-0.7	-0.5	0.1	-0.4	0.5	-0.7	-0.7	-0.9	-0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	0.1	-0.9	-0.8	-1.0	-1.1	-0.4	-1.1	-1.0	-0.8	-0.8	-1.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	-0.4	0.2	0.9	0.6	0.5	-0.5	1.1	1.2	0.7	0.7	0.5	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	1.4	-0.5	-1.1	-1.0	-0.3	-0.7	-1.0	1.2	-1.0	-1.1	-1.1	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	4.4	1.4	-0.8	0.1	0.0	0.2	-2.1	0.5	0.4	0.0	0.1	-0.3	0.9
Pain all over the body in last month	0.6	0.6	1.6	-0.0	0.1	-0.8	-0.5	-1.3	-0.5	-0.9	-1.1	-0.8	-0.9	-0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	3.8	-0.2	-0.0	-0.4	-0.2	-0.2	-1.7	0.6	2.0	0.2	-0.3	-0.7	-0.8
Fluid intelligence score	0.6	1.2	6.8	0.6	-0.2	-0.8	0.0	-1.5	-2.6	-0.1	-0.5	-0.7	-0.7	-0.4	-1.6
Number of live births	0.6	0.9	2.1	-1.3	-0.6	0.9	0.6	1.5	0.7	0.7	0.9	1.0	0.9	0.8	0.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.7	0.3	-0.3	1.0	1.2	-0.2	1.9	1.3	1.0	1.0	0.9	1.0	-0.1
Exposure to tobacco smoke at home	0.6	0.7	4.9	-0.7	-0.3	0.5	0.4	0.6	-0.1	1.2	2.2	0.6	0.5	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.1	0.4	1.3	0.8	0.5	1.4	-0.7	1.0	1.1	0.8	0.9	0.5	1.4
Glaucoma (self-reported)	0.6	0.7	3.1	0.4	-0.2	0.8	0.4	0.8	-0.1	1.4	1.8	0.8	0.7	0.4	0.8
High blood pressure (siblings)	0.6	0.9	4.1	1.9	-0.5	-0.1	-0.4	-0.3	2.0	-1.2	0.8	-0.3	-0.1	-0.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	6.2	2.5	-0.3	0.6	0.5	-0.1	0.1	0.1	-0.0	0.3	0.6	0.4	1.0
Age at first live birth	0.6	1.0	4.0	2.0	1.8	0.6	0.6	0.7	1.0	0.9	-1.0	0.7	0.7	0.7	-0.2
Qualifications: College or University degree	0.6	1.8	3.5	-0.4	1.7	1.6	1.7	0.7	1.7	1.2	0.5	1.4	1.6	1.9	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	5.0	-2.2	-0.9	-0.3	-0.4	-0.5	0.2	-0.4	-0.5	-0.6	-0.5	-0.4	-0.7
Leg fat mass (right)	0.6	2.3	5.6	-0.1	0.0	1.7	1.6	1.1	0.1	2.4	2.1	1.9	1.6	1.1	1.9
Family relationship satisfaction	0.6	0.7	2.9	-1.0	-0.5	-0.5	-0.2	-1.5	-1.7	-0.4	-0.2	-0.7	-0.6	-0.5	-0.8
Ever had bowel cancer screening	0.6	0.7	3.3	-0.5	0.4	0.8	0.8	0.6	1.8	0.7	0.3	0.8	0.7	0.9	0.2
Osteoporosis (self-reported)	0.6	0.8	6.6	-0.6	-2.6	-0.2	-0.0	-0.7	0.6	0.5	-0.3	-0.0	-0.2	-0.1	-1.0
Illnesses of father: High blood pressure	0.6	0.7	1.9	1.2	-0.7	-0.9	-0.9	0.2	1.1	-1.4	0.4	-0.9	-0.9	-0.5	0.2
Leg fat percentage (left)	0.6	2.3	4.8	-0.7	-0.2	1.8	1.9	0.9	0.5	2.2	1.8	1.9	1.7	1.4	1.8
Fractured/broken bones in last 5 years	0.6	0.8	1.7	0.2	-0.3	-0.8	-1.2	-1.3	0.7	-1.0	-0.2	-0.6	-0.8	-1.2	-1.0
Heart disease (siblings)	0.6	0.7	1.5	-0.8	-1.1	-0.8	-0.6	-0.5	1.0	-1.2	-1.0	-0.7	-0.8	-0.2	-0.9
Alcohol drinker status: Previous	0.6	0.6	1.4	-0.1	-1.0	-0.9	-0.4	-0.8	1.2	-1.0	-0.3	-0.6	-0.9	-0.6	-1.0
Depression (Nagel 2018)	0.5	0.8	2.5	0.5	0.6	0.7	0.4	1.5	0.5	0.7	1.2	0.8	0.7	0.6	1.6
Irritable Bowel Disease (IBD)	0.5	1.1	6.6	-2.6	-1.2	-0.3	-0.2	-1.0	-1.0	-0.6	-1.6	-0.5	-0.3	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	6.8	1.6	-0.5	-0.2	0.6	-1.8	-2.6	0.8	0.1	0.0	-0.1	-0.1	-1.4
Rheumatoid Arthritis	0.5	0.6	2.3	-0.7	-1.1	-0.8	-0.6	-0.9	-1.5	-0.2	0.1	-0.6	-0.7	-0.9	-0.3
Ulcerative Colitis	0.5	0.8	3.1	-0.9	-1.2	-0.4	-0.1	-1.3	-0.5	-0.3	-1.8	-0.3	-0.4	-0.1	-1.2
Neuroticism	0.5	1.2	3.4	1.3	1.5	0.4	0.6	1.5	-0.7	1.4	1.9	0.8	0.5	0.6	1.0
Sensitivity / hurt feelings	0.5	0.8	2.9	-0.4	0.8	0.5	0.4	1.4	-0.4	1.7	1.2	1.1	0.6	0.7	0.0
Diabetes (mother)	0.5	0.6	4.7	-2.2	0.2	-0.3	-0.8	1.0	-0.6	-0.3	-0.6	-0.3	-0.3	-0.3	0.2
Severe depression (siblings)	0.5	0.6	3.3	-1.8	-0.5	0.6	0.8	-0.4	-0.3	1.3	-0.0	0.6	0.4	0.7	-0.1
Townsend deprivation index at recruitment	0.5	0.7	3.0	1.1	-0.3	0.5	0.6	0.7	1.4	0.6	1.7	0.4	0.4	0.6	0.6
Current tobacco smoking	0.5	0.8	3.8	2.0	-1.1	-0.5	-1.2	-0.1	-0.1	-0.8	0.5	-0.6	-0.5	-1.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	1.3	0.3	0.4	0.3	0.8	-0.6	1.0	1.5	0.6	0.5	0.3	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.6	0.8	-1.6	-1.3	-1.4	-0.9	-0.7	-1.2	0.4	-1.2	-1.1	-1.4	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	1.3	-0.7	-0.9	-0.8	-0.6	-0.0	0.1	0.8	-0.4	-1.0	-1.0	-0.7
Trunk fat mass	0.5	2.0	3.6	0.1	0.5	1.7	1.6	0.9	0.4	1.8	1.8	1.8	1.6	1.3	1.9
Waist circumference	0.5	1.8	4.0	-0.3	0.2	1.6	1.5	0.7	0.9	2.0	1.5	1.9	1.5	1.2	1.1
Financial difficulties in last 2 years	0.5	0.7	1.3	0.7	-0.1	-1.1	-0.9	-0.8	-0.5	-1.0	0.8	-0.8	-1.1	-0.9	-0.8
Heart attack	0.5	0.7	3.7	-0.4	-0.8	-0.4	-0.1	-1.9	0.1	-0.1	-0.9	-0.3	-0.4	-0.3	-1.5
Neuroticism score	0.5	1.0	3.0	1.5	1.3	-0.2	-0.1	1.3	-0.9	1.4	1.7	0.6	0.0	-0.1	0.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.0	0.3	0.6	1.3	1.6	0.9	-2.2	2.0	0.5	1.6	1.2	1.3	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.5	1.6	1.4	-0.5	-0.7	0.8	0.6	-0.9	-0.3	-0.4	-0.4	-0.3	-0.4
Headache pain in last month	0.5	0.8	2.7	-1.6	-1.3	-0.6	-0.7	0.6	-1.1	-0.7	0.7	-0.5	-0.5	-0.8	0.8
Gout (self-reported)	0.5	0.7	3.3	-1.8	-0.5	0.0	-0.4	-0.3	-1.2	-0.0	-1.6	-0.6	-0.1	-0.4	-0.1
Body fat percentage	0.5	1.9	3.3	-0.3	0.2	1.7	1.7	0.5	0.5	1.7	1.8	1.6	1.6	1.2	1.8
Mean time to correctly identify matches	0.5	1.0	4.3	-0.0	-0.7	-0.5	-0.8	-0.3	2.1	-2.0	1.1	-0.7	-0.5	-0.4	0.8
Whole body fat mass	0.5	2.0	4.0	0.2	0.2	1.8	1.6	0.8	0.4	2.0	1.8	1.8	1.6	1.2	1.8
Suffer from ‘nerves’	0.5	0.8	2.5	1.6	-0.5	-0.9	-0.9	-0.1	-1.4	-0.2	1.1	-0.8	-0.9	-1.1	0.0
Average weekly red wine intake	0.5	0.8	1.6	0.4	1.2	0.9	1.3	0.7	0.2	1.1	0.8	1.0	0.9	1.2	0.1
Medication for cholesterol	0.5	0.8	4.7	0.4	2.2	0.5	0.5	1.1	-0.9	0.8	0.4	0.8	0.6	0.5	0.5
Smoking status: Current	0.5	0.8	4.1	2.0	-1.0	-0.4	-1.1	0.2	-0.4	-0.6	0.7	-0.5	-0.3	-1.0	0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.4	-0.2	1.0	-1.0	-1.2	-0.1	-0.5	-0.8	-1.2	-0.5	-0.9	-1.0	-1.0
Wears glasses or contact lenses	0.5	0.6	5.8	-0.0	-0.4	0.2	-0.0	0.8	2.4	-0.0	0.4	0.2	0.0	0.4	-0.2
Myopia	0.5	0.8	1.8	1.1	1.2	0.8	1.0	-0.6	1.4	-0.4	0.5	0.3	0.9	0.9	0.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.8	0.6	2.2	1.2	1.0	1.4	-0.6	1.0	0.7	1.0	1.3	1.1	1.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.0	0.8	1.4	0.7	0.7	0.3	0.9	0.0	0.7	0.6	0.8	0.7	0.5
Worry (Nagel 2018)	0.4	0.8	6.2	2.5	0.8	-0.4	-0.2	0.4	0.2	0.3	1.4	0.2	-0.2	-0.2	0.3
Breast Cancer	0.4	0.9	4.2	1.9	0.6	0.4	0.7	0.2	2.0	0.2	0.2	0.8	0.3	0.8	-0.4
Bipolar Disorder (2011)	0.4	0.4	2.0	-0.8	-1.4	0.2	0.3	-0.1	0.3	1.0	-0.7	0.1	0.2	0.2	-0.8
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	1.2	-0.9	0.5	0.6	-0.1	-1.0	0.8	0.9	0.5	0.5	0.3	0.5
HDL Cholesterol	0.4	0.6	1.4	-0.8	-1.1	-0.8	-0.9	-0.3	-0.1	-1.0	-0.0	-1.2	-0.9	-1.0	-0.2
LDL Cholesterol	0.4	0.6	2.9	0.3	-1.7	-0.4	-0.3	0.4	0.7	0.8	-1.1	0.0	-0.6	0.0	-1.0
Cardiovascular Disease	0.4	1.3	2.5	-1.6	-1.3	-1.2	-1.0	-1.0	0.5	-1.0	-1.0	-1.0	-1.2	-1.0	-1.4
Hypothyroidism (self reported)	0.4	1.0	3.4	-0.2	1.0	0.7	0.7	1.8	0.3	1.0	1.5	0.8	0.7	0.8	1.2
Tanning	0.4	4.6	7.7	-1.4	-1.4	-2.3	-2.4	-2.2	-1.8	-2.5	-1.8	-2.8	-2.4	-2.4	-1.6
Hand grip strength (left)	0.4	1.0	2.1	0.1	1.3	1.1	1.1	1.2	0.1	1.5	0.2	1.5	1.0	1.1	0.4
Number of treatments/medications taken	0.4	0.8	3.1	-1.6	-1.8	-0.1	0.2	-0.4	0.8	-0.1	1.6	-0.0	-0.1	-0.2	-0.1
Hearing difficulty/problems: Yes	0.4	0.5	1.7	-0.8	-1.3	-0.4	-0.7	0.8	0.9	-1.3	-0.4	-0.5	-0.4	-0.1	0.3
Systolic blood pressure, automated reading	0.4	1.1	4.7	0.5	0.3	0.4	0.1	1.8	1.5	1.1	2.2	0.9	0.3	0.3	0.7
Relative age voice broke	0.4	0.6	2.1	-1.2	-0.1	-0.6	0.0	-0.7	-0.6	0.2	-1.4	-0.5	-0.6	-0.3	-1.2
High blood pressure	0.4	1.2	3.5	-0.4	-1.9	-1.2	-1.2	-1.1	0.6	-0.9	-0.4	-0.9	-1.3	-1.1	-1.4
Medication: Atenolol	0.4	0.5	1.5	-0.3	-0.8	-0.6	-0.7	-0.8	0.9	-0.6	-0.7	-0.6	-0.7	-0.5	-1.2
Nervous feelings	0.4	0.7	2.6	1.5	-0.6	-0.9	-0.6	-0.5	-1.6	0.6	0.7	-0.4	-0.9	-0.8	-0.2
Weight	0.4	2.1	3.7	0.8	0.5	1.6	1.1	1.5	0.5	1.8	1.9	1.8	1.5	1.0	1.9
Time employed in main current job	0.4	0.4	1.6	-0.7	-0.7	-0.1	-0.4	0.1	1.0	-0.2	-1.1	-0.1	-0.1	-0.0	-1.3
Hair/balding pattern: Pattern 3	0.4	0.7	1.3	-0.0	0.8	1.0	1.1	-0.2	0.1	1.1	1.0	1.0	0.9	0.8	0.5
Pulse rate	0.4	0.7	1.4	-1.0	1.1	0.1	0.5	1.2	1.2	1.2	0.8	0.9	0.0	0.5	-0.3
Depression (self-reported)	0.4	0.5	2.6	0.9	1.1	-0.0	0.4	0.6	-0.9	0.5	1.6	0.4	0.1	0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.1	-1.0	1.3	-0.5	-0.0	-1.5	-0.8	-0.8	0.3	-0.6	-0.6	-0.4	-0.5
Blood clot in the leg (DVT)	0.4	0.5	1.8	0.6	1.4	0.7	0.5	0.5	0.8	0.0	0.7	0.6	0.8	0.6	0.6
Arm fat-free mass (right)	0.4	1.9	4.9	0.6	0.9	1.3	0.6	2.2	0.1	1.9	1.7	1.7	1.2	0.8	1.7
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-1.1	-1.3	-0.4	-0.6	0.3	-0.4	0.9	1.0	0.1	-0.4	-0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.3	1.1	0.0	-0.7	-0.3	-1.2	-0.3	-0.7	-0.6	-0.8	-0.7	-0.6	-0.8
Number of children fathered	0.4	0.5	1.9	-1.1	-1.4	-0.6	-0.5	-0.4	-0.3	-0.2	-0.2	-0.5	-0.6	-0.6	-0.8
Shortness of breath walking on level ground	0.4	0.5	2.5	1.6	0.3	-0.6	-0.4	-0.7	0.0	-0.7	-0.7	-0.8	-0.7	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.4	0.6	2.7	0.0	1.1	-0.5	-0.1	-0.8	-1.6	0.5	-1.1	-0.3	-0.5	-0.7	-0.8
Arm predicted mass (right)	0.4	2.2	5.5	0.6	0.8	1.4	0.8	2.3	-0.1	2.1	1.8	1.9	1.4	1.0	1.8
Chest pain or discomfort	0.4	0.6	3.1	-0.3	0.1	0.4	0.4	0.5	1.6	0.5	1.7	0.6	0.4	0.4	0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.3	-0.4	0.1	0.9	0.7	0.2	-0.7	1.2	0.3	0.7	0.9	0.5	0.4
Eye problems/disorders: Cataract	0.4	0.5	4.6	-2.2	0.1	0.3	0.3	0.5	0.6	0.1	-0.3	0.2	0.3	0.5	0.0
Mineral and other dietary supplements	0.4	0.5	4.3	2.1	0.2	0.2	0.1	0.1	-0.0	-0.4	-1.2	-0.2	0.2	0.3	0.3
Osteoarthritis (self-reported)	0.4	0.5	1.3	-0.4	-0.5	0.7	1.1	-0.5	-0.6	0.8	1.0	0.6	0.7	0.5	0.6
Medication: Aspirin	0.4	0.5	1.6	-0.5	-0.7	-0.4	-0.6	-0.7	1.3	-1.0	-0.3	-0.2	-0.4	-0.3	-1.1
Mother’s age at death	0.4	0.5	2.1	0.1	-1.4	-0.8	-1.0	-0.1	-0.5	-0.3	-0.3	-0.6	-0.8	-0.8	-0.4
Medication: Bendroflumethiazide	0.4	0.6	3.6	0.2	-0.3	0.5	0.4	0.8	1.9	-0.1	1.2	0.5	0.5	0.5	0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.6	3.3	-0.3	-0.6	-0.3	0.0	-1.8	0.2	0.0	-0.8	-0.2	-0.3	-0.2	-1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	5.2	-0.9	-2.3	-0.6	-0.7	0.3	0.5	0.6	0.2	-0.2	-0.6	-0.6	-1.0
Neuroticism (Nagel 2018)	0.3	0.6	2.3	1.5	1.0	-0.1	-0.0	1.0	-0.7	0.7	1.2	0.4	0.1	0.0	0.7
Alzheimer’s Disease (in father)	0.3	0.3	1.3	-0.0	0.3	-0.1	-0.4	1.1	0.1	-1.1	-0.2	-0.2	-0.0	0.1	1.0
Crohns Disease (2017)	0.3	0.7	4.2	-2.1	-0.1	0.7	0.8	0.1	0.2	-0.2	-1.0	0.3	0.7	1.0	0.4
Mean Putamen Volume	0.3	0.3	1.5	-0.6	0.1	0.1	-0.2	0.2	-1.2	0.3	1.1	-0.1	0.1	-0.3	0.8
Lupus	0.3	0.4	1.1	0.7	0.5	-0.8	-0.4	-0.6	-0.7	-0.0	1.1	-0.2	-0.8	-0.9	-0.6
Neuroticism (2016)	0.3	0.4	1.2	0.3	0.5	0.4	0.3	1.0	-0.8	1.1	0.5	0.6	0.5	0.5	0.3
Blood Red Count	0.3	3.0	7.0	-1.0	-0.6	1.8	1.8	2.0	0.9	2.6	1.9	2.2	1.8	1.9	1.0
Allergy or Eczema	0.3	0.8	2.4	0.3	0.3	-0.8	-0.4	-1.0	-1.6	0.5	1.2	-0.6	-0.8	-1.1	-0.9
Average weekly spirits intake	0.3	0.4	2.5	0.1	-1.2	-0.1	-0.5	-0.7	-0.2	0.3	1.6	0.2	-0.1	-0.6	-0.1
Leg fat-free mass (left)	0.3	1.6	2.9	1.7	1.0	1.3	0.8	1.4	-0.1	1.4	1.4	1.5	1.2	0.8	1.7
Trunk fat percentage	0.3	1.4	2.5	-0.2	0.2	1.5	1.5	0.3	0.5	1.3	1.6	1.4	1.3	1.1	1.6
Average weekly fortified wine intake	0.3	0.4	1.3	0.2	-0.2	-0.4	-0.0	-1.2	0.2	-0.1	-1.2	-0.2	-0.6	-0.2	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.5	0.2	0.7	-0.7	-0.5	-0.9	-1.1	0.1	1.6	-0.4	-0.7	-0.9	-1.0
Multivitamins +/- minerals	0.3	0.3	1.7	-0.5	0.5	0.2	0.3	-0.9	-1.3	0.5	0.6	0.4	0.2	0.1	-0.0
High blood pressure (mother)	0.3	0.4	2.9	-0.0	0.3	0.2	-0.1	0.6	1.7	0.0	-0.6	0.2	0.1	0.4	-0.6
Leg predicted mass (left)	0.3	1.7	2.9	1.7	1.0	1.3	0.8	1.4	-0.0	1.4	1.4	1.6	1.3	0.8	1.7
Hearing difficulty/problems with background noise	0.3	0.4	2.4	-0.4	-0.5	0.5	0.4	0.4	1.6	-0.8	0.3	0.1	0.5	0.8	0.5
Mouth/teeth dental problems	0.3	0.5	3.2	-1.4	-0.8	-0.1	0.1	-0.5	-1.8	0.4	-0.1	-0.1	-0.1	-0.3	0.4
Allergy	0.3	0.7	3.9	-0.5	-0.5	0.2	-0.3	0.8	1.5	-0.7	-2.0	-0.1	0.1	0.4	0.6
Medication: Simvastatin	0.3	0.4	3.2	-1.3	-0.5	0.0	0.1	0.1	1.8	-0.1	-0.2	0.2	0.0	0.2	-0.4
Trunk fat-free mass	0.3	1.6	4.2	1.2	0.9	1.1	0.4	2.1	-0.4	1.7	1.3	1.6	1.1	0.6	1.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.2	0.1	-0.6	-0.6	-0.9	0.1	-0.3	-0.9	-0.6	-0.6	-0.9	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	2.1	-1.4	-0.7	0.5	0.4	0.3	0.3	0.6	0.2	0.5	0.4	0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.2	0.2	0.5	1.2	1.4	-0.1	-1.8	1.2	0.3	1.1	1.1	1.2	0.4
Arm fat mass (right)	0.3	1.2	2.5	0.4	0.2	1.4	1.2	0.3	0.1	1.5	1.6	1.4	1.2	0.7	1.4
Trunk predicted mass	0.3	1.7	4.7	1.1	1.0	1.2	0.5	2.2	-0.3	1.8	1.4	1.7	1.2	0.7	1.6
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	0.9	0.8	0.4	0.8	1.5	1.1	0.8	1.3	1.0	0.6	0.7	0.6
Peak expiratory flow (PEF)	0.3	0.7	3.0	0.3	0.1	0.4	0.6	0.5	-1.3	1.7	-0.3	1.1	0.4	0.5	-0.8
Medication: Paracetamol	0.3	0.5	1.8	1.4	-1.2	-0.2	-0.2	0.3	0.1	-1.1	0.1	-0.5	-0.2	0.1	0.9
Neck or shoulder pain in last month	0.3	0.5	2.8	1.7	-0.9	-0.1	-0.3	0.1	-0.6	0.0	1.2	-0.3	-0.1	-0.4	0.5
Angina (self-reported)	0.3	0.4	2.6	-0.9	-1.6	-0.2	0.3	-0.7	0.5	0.2	-0.1	0.0	-0.2	0.1	-0.8
Migraine (self-reported)	0.3	0.4	2.4	-1.5	-0.3	0.6	0.6	-0.1	-0.4	0.4	-0.4	0.5	0.5	0.5	0.0
Had major operations	0.3	0.4	0.8	-0.1	0.4	0.8	0.5	0.9	0.7	0.5	0.6	0.7	0.8	0.4	0.8
Hypertension (Self-reported)	0.3	0.8	3.0	-0.7	-1.7	-0.7	-0.6	-0.8	1.3	-0.5	-0.2	-0.5	-0.8	-0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.5	1.3	1.6	-0.4	-0.4	0.5	-1.0	-1.2	0.3	-0.4	-0.3	-0.1	0.6
Whole body fat-free mass	0.3	1.8	4.0	1.4	1.0	1.3	0.6	2.0	-0.1	1.6	1.5	1.7	1.3	0.8	1.7
Leg fat-free mass (right)	0.3	1.5	2.7	1.6	1.0	1.3	0.8	1.3	0.0	1.2	1.3	1.5	1.3	0.9	1.6
Whole body water mass	0.3	1.7	3.7	1.4	1.0	1.3	0.6	1.9	-0.0	1.5	1.4	1.6	1.3	0.8	1.7
Leg predicted mass (right)	0.3	1.7	2.8	1.6	1.2	1.4	0.9	1.4	0.0	1.3	1.4	1.5	1.4	1.0	1.7
Arm fat mass (left)	0.3	1.3	2.6	0.3	0.4	1.4	1.3	0.4	0.1	1.6	1.6	1.5	1.3	0.8	1.4
Hearing aid user	0.3	0.3	1.7	0.0	-0.3	-0.6	-0.4	-0.7	0.3	-1.3	0.0	-0.7	-0.5	-0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	1.1	0.6	-0.9	-0.3	-0.2	-0.6	-0.6	0.5	-0.4	-0.7	-0.4	-0.3
High cholesterol (Self-reported)	0.3	0.6	2.0	-1.3	0.0	0.6	0.8	0.1	1.4	0.8	-0.2	0.7	0.6	0.8	-0.8
Basal metabolic rate	0.3	1.6	3.0	1.2	0.9	1.3	0.7	1.7	-0.2	1.6	1.5	1.6	1.2	0.8	1.7
Arm fat-free mass (left)	0.3	1.4	3.3	0.2	0.6	1.3	0.7	1.8	-0.1	1.8	1.1	1.6	1.2	0.8	1.4
Number of operations (self-reported)	0.3	0.4	0.8	-0.5	0.2	0.6	0.9	0.1	0.8	0.9	0.7	0.9	0.7	0.5	0.2
Risk taking	0.3	0.4	1.3	-0.3	-0.2	-0.6	-0.8	-0.8	-1.2	-0.3	-0.2	-0.8	-0.5	-1.0	-0.5
Commuting to job workplace: Cycle	0.3	0.3	1.5	1.2	1.0	-0.2	-0.3	-0.4	-0.1	-0.8	-0.2	-0.4	-0.1	-0.2	0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	2.0	-0.5	0.4	0.3	0.4	-0.6	0.7	0.0	1.4	0.3	0.2	0.3	-0.0
Arm predicted mass (left)	0.3	1.5	4.4	0.4	0.7	1.2	0.5	2.1	0.1	1.6	1.4	1.6	1.2	0.8	1.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.2	0.3	1.5	0.6	1.1	-0.3	-0.1	1.2	1.0	0.8	0.6	0.9	-0.7
Prostate Cancer	0.2	0.3	1.2	-1.1	-0.2	0.1	-0.1	0.5	-0.9	0.5	-0.7	0.3	0.1	0.1	-0.1
Crohns Disease (2012)	0.2	0.4	1.9	-0.5	-0.2	0.0	0.1	-0.1	1.2	-0.9	-1.4	-0.1	0.0	0.4	-0.2
Fasting Glucose	0.2	0.2	0.8	0.9	-0.9	-0.2	-0.0	0.3	0.2	0.3	0.2	0.2	-0.1	-0.1	0.5
Primary Biliary Cirrhosis	0.2	0.3	2.2	-0.3	-1.5	-0.3	-0.0	-0.8	0.4	-0.4	0.1	-0.2	-0.3	-0.1	-0.8
Schizophrenia (2014)	0.2	0.4	1.6	-1.0	-0.8	0.2	0.3	0.4	-0.3	1.2	0.1	0.6	0.3	0.1	-0.7
Blood White Count	0.2	1.3	6.2	-1.5	-1.8	0.2	0.5	-0.7	2.5	-0.5	-1.7	-0.1	0.0	0.6	-0.4
Height	0.2	3.9	8.8	0.3	3.0	1.7	1.7	2.4	2.2	2.6	1.5	2.5	1.6	2.1	0.2
Systolic Blood Pressure	0.2	1.1	4.3	-0.2	0.8	0.4	0.5	2.1	1.0	0.8	2.0	1.1	0.4	0.6	0.7
Respiratory disease	0.2	0.4	1.2	1.1	-0.1	-0.8	-0.6	-0.3	-0.4	-0.5	0.7	-0.4	-0.8	-0.5	-0.6
Lung FVC	0.2	0.8	4.0	-0.1	-0.6	0.9	1.1	-1.0	-2.0	-0.0	0.6	0.3	0.9	0.5	0.6
Relative age of first facial hair	0.2	0.3	0.8	0.6	0.8	0.5	0.3	0.9	0.6	0.8	-0.3	0.5	0.5	0.3	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	1.1	-1.0	0.5	0.2	0.1	-0.1	1.0	-0.6	-0.2	-0.1	0.1	0.3	0.2
Angina	0.2	0.3	1.6	-0.6	-1.3	0.0	0.5	-0.4	0.7	0.4	0.3	0.3	0.1	0.3	-0.5
Vitamin and mineral supplements	0.2	0.2	0.6	-0.2	-0.2	-0.6	-0.8	0.2	-0.0	-0.6	-0.5	-0.7	-0.6	-0.6	-0.2
Medication: Co-codamol	0.2	0.2	1.4	-0.6	-0.1	0.3	-0.0	-0.3	0.5	-0.5	-1.2	-0.2	0.2	0.4	0.0
Sitting height	0.2	1.6	6.9	0.8	1.9	0.8	0.7	2.6	-0.2	1.0	1.1	1.0	0.8	1.2	1.4
Body mass index (BMI)	0.2	1.0	3.4	0.4	-0.4	1.1	0.8	0.4	0.0	1.3	1.8	1.1	1.0	0.3	1.4
Forced vital capacity (FVC)	0.2	0.6	5.1	0.5	-0.5	0.5	0.6	0.0	-2.3	0.2	-0.6	0.3	0.5	0.6	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	3.4	0.9	-1.8	-0.3	-0.1	-0.5	-0.6	0.2	0.8	-0.1	-0.3	-0.5	-0.0
Arm fat percentage (right)	0.2	0.6	1.6	0.3	0.2	1.0	1.0	-0.5	-0.1	0.8	1.3	0.8	0.9	0.3	1.2
Worrier / anxious feelings	0.2	0.3	1.4	0.2	-0.3	-0.3	-0.3	0.7	-0.9	1.2	0.7	0.4	-0.2	-0.3	-0.2
Happiness	0.2	0.2	0.9	1.0	0.4	0.3	0.4	0.5	-0.6	0.6	-0.1	0.2	0.3	0.6	-0.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	2.9	-0.5	1.7	0.1	0.5	-0.7	0.3	0.2	0.1	0.3	0.0	0.4	-0.5
Asthma	0.2	0.4	2.1	0.0	0.0	-0.2	0.3	-0.1	-0.9	1.2	1.5	0.4	-0.1	-0.0	-0.3
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.6	0.1	-0.4	-0.0	-0.6	0.8	-0.7	-0.5	-0.4	-0.4	0.1	-0.8
Prospective memory result	0.2	0.3	2.5	-0.7	-1.6	-0.1	-0.3	0.1	0.2	0.3	-0.4	0.1	-0.1	-0.2	0.3
Standing height	0.2	1.7	5.6	0.8	1.7	1.2	0.9	2.4	0.8	1.3	0.2	1.6	1.1	1.5	1.0
Loud music exposure frequency	0.2	0.2	0.8	0.6	-0.1	0.2	0.1	0.4	0.5	0.9	0.4	0.6	0.2	-0.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.5	-0.6	-0.4	0.2	0.4	0.7	0.5	0.5	1.2	0.3	0.2	0.4	0.4
Medication: Ibuprofen	0.2	0.3	1.8	-1.3	-0.6	-0.4	-0.4	-0.2	-0.0	0.0	0.6	-0.2	-0.5	-0.4	-0.3
Medication: Omeprazole	0.2	0.2	0.9	-0.4	0.6	0.0	0.1	-0.3	0.9	-0.1	1.0	-0.0	-0.0	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	-0.7	0.8	0.7	0.1	0.3	-0.2	0.1	0.5	0.6	0.7	0.3	0.8
Arm fat percentage (left)	0.2	1.0	2.1	0.4	0.4	1.2	1.3	-0.2	0.0	1.1	1.4	1.1	1.1	0.7	1.4
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.5	0.2	-0.5	-0.5	-0.1	-0.1	0.1	-0.7	-0.2	-0.5	-0.2	-0.9
Loneliness, isolation	0.2	0.3	1.3	0.2	0.9	-0.1	0.1	0.8	-0.2	1.0	1.1	0.4	0.0	0.0	-0.1
Friendships satisfaction	0.2	0.2	0.9	-0.6	-0.3	0.3	0.7	-0.1	-0.6	0.1	0.3	0.2	0.3	1.0	-0.2
Asthma (self-reported)	0.2	0.4	2.0	0.1	0.3	-0.0	0.4	0.1	-0.5	1.3	1.4	0.6	-0.0	0.1	-0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	-0.1	-0.6	0.2	-0.7	0.3	0.9	-0.3	0.3	0.0	0.1	-0.4	1.0
Medication: Paracetamol	0.2	0.3	1.2	0.9	-0.3	0.2	0.4	1.1	0.2	-0.2	0.6	0.2	0.2	0.6	1.0
Alcohol drinker status: Never	0.2	0.3	1.0	-1.0	1.0	0.2	0.6	-0.3	0.1	-0.3	0.3	-0.0	0.3	0.4	0.3
Cholesterol lowering medication	0.2	0.4	2.3	0.1	-1.2	-0.1	-0.4	-0.0	1.5	-0.2	0.0	-0.1	-0.1	-0.2	-0.4
Schizophrenia (2018)	0.1	0.3	1.7	-0.8	-1.3	0.1	-0.0	0.2	-0.3	0.5	0.3	0.3	0.1	-0.2	-0.1
Blood Eosinophil Count	0.1	0.8	3.9	-0.0	-0.6	-0.5	-0.7	-0.9	0.4	-1.1	-2.0	-0.9	-0.6	-0.5	-0.8
Blood Platelet Count	0.1	1.0	2.0	1.2	-0.2	-1.2	-1.1	-0.2	1.4	-1.4	-0.5	-1.0	-1.3	-0.6	-0.4
Waist Hip Ratio (WHR)	0.1	0.5	2.1	-0.6	-1.4	-0.4	-0.3	-1.4	-0.1	-0.4	-0.8	-0.3	-0.4	-0.5	-0.7
Impedance of leg (right)	0.1	0.4	3.6	-1.9	0.1	-0.2	0.3	0.1	-0.0	0.3	-0.6	-0.0	-0.2	0.3	-0.6
Medication: Levothyroxine sodium	0.1	0.2	1.0	-0.2	-1.0	-0.3	-0.3	0.3	0.6	-0.3	0.0	-0.5	-0.4	-0.1	0.3
Impedance of leg (left)	0.1	0.5	4.7	-2.2	0.0	0.0	0.5	0.2	0.0	0.3	-0.6	0.1	-0.0	0.5	-0.4
Impedance of arm (right)	0.1	0.6	2.2	-0.7	0.1	-0.5	0.1	-1.5	-0.4	-1.1	-1.3	-0.8	-0.5	0.0	-0.9
Falls in the last year	0.1	0.2	1.1	-0.3	0.1	0.0	-0.1	-0.1	1.1	-0.2	0.8	0.1	0.0	0.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.6	0.4	0.4	0.1	0.4	0.1	0.8	0.5	-0.2	0.2	0.0	0.4	-0.7
Impedance of arm (left)	0.1	0.4	1.1	-0.4	0.7	-0.1	0.6	-1.0	0.2	-0.6	-1.0	-0.3	-0.1	0.5	-0.7
Birth weight	0.1	0.3	1.0	0.5	1.0	-0.1	-0.3	0.6	-0.9	-0.8	-0.7	-0.0	0.1	0.2	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	4.2	0.4	-0.5	0.4	0.4	-0.6	-2.1	-0.2	-0.4	-0.1	0.3	0.4	0.4
Pulse rate, automated reading	0.1	0.2	0.6	-0.5	0.4	-0.7	-0.2	0.1	0.7	-0.3	-0.4	-0.3	-0.8	-0.4	-0.2
Alcohol intake frequency.	0.1	0.3	1.5	-1.2	-0.5	-0.2	0.2	-0.5	0.9	-0.0	0.8	-0.0	-0.2	-0.0	-0.2
Breast cancer (self-reported)	0.1	0.1	0.9	1.0	0.2	0.2	0.2	-0.2	0.1	0.3	-0.5	0.3	0.1	0.2	-0.1
Irritability	0.1	0.2	0.8	0.2	0.6	-0.4	-0.3	0.9	-0.6	0.3	0.3	0.0	-0.2	-0.1	-0.1
Impedance of whole body	0.1	0.5	3.2	-1.8	0.5	0.0	0.6	-0.4	-0.1	-0.1	-1.0	-0.1	-0.0	0.6	-0.5
BMI	0.0	0.2	0.6	-0.3	-0.8	0.2	0.1	-0.2	-0.8	0.6	0.5	0.1	0.1	-0.3	0.6
Hair Pigment	0.0	0.6	2.3	0.9	-0.0	0.5	0.7	0.6	1.5	-0.7	-0.0	0.1	0.5	0.9	1.2

Hub : Genes

EEF1E1

Models

Trait associations