TWAS hub - FANCE

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0260	0.0150	0.0180	0.016	0.01	0.003	0.01	0.009	0.0039	0.021	0.11	0.017	0.022
2	YFS	Blood	0.0148	0.0075	0.0049	-0.001	0.00	-0.001	0.00	-0.001	0.7300	0.310	1.00	0.320	0.830

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1), Best measure	18.3	58.5	108.2	-10.4	-3.0
Forced expiratory volume in 1-second (FEV1)	17.4	58.5	108.2	-10.4	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	16.7	34.7	68.9	-8.3	-0.7
Trunk fat-free mass	15.8	90.4	146.4	-12.1	-5.9
Trunk predicted mass	15.5	88.8	144.0	-12.0	-5.8
Standing height	13.9	137.9	262.4	-16.2	-3.6
Whole body fat-free mass	13.8	79.1	125.4	-11.2	-5.7
Arm fat-free mass (right)	13.7	70.1	121.0	-11.0	-4.4
Arm predicted mass (right)	13.7	69.9	118.8	-10.9	-4.6
Whole body water mass	13.7	77.9	123.2	-11.1	-5.7
Arm fat-free mass (left)	12.8	65.0	106.1	-10.3	-4.9
Forced vital capacity (FVC), Best measure	12.4	45.2	78.3	-8.8	-3.5
Basal metabolic rate	12.4	68.4	110.2	-10.5	-5.2
Arm predicted mass (left)	12.4	63.2	104.0	-10.2	-4.7
Forced vital capacity (FVC)	12.0	46.1	80.6	-9.0	-3.4
Height	11.4	219.4	432.6	-20.8	-2.5
Comparative height size at age 10	10.8	59.2	112.4	-10.6	-2.5
Leg predicted mass (left)	10.5	55.5	84.2	-9.2	-5.2
Leg fat-free mass (left)	10.3	54.7	83.7	-9.2	-5.1
Leg predicted mass (right)	10.1	53.7	79.0	-8.9	-5.3
Leg fat-free mass (right)	10.0	53.3	79.2	-8.9	-5.2
Lung FEV1/FVC ratio	8.3	42.1	84.1	-9.2	-0.3
Weight	7.0	34.6	58.7	-7.7	-3.2
Peak expiratory flow (PEF)	6.7	15.6	30.0	-5.5	-1.0
Birth weight of first child	6.0	10.9	20.2	-4.5	-1.3
Asthma	5.9	11.6	20.4	4.5	-1.7
Sitting height	5.6	39.4	75.0	-8.7	-2.0
Asthma (self-reported)	5.4	10.8	19.3	4.4	-1.6
Blood Eosinophil Count	5.2	40.3	68.8	3.4	8.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.2	10.9	21.5	-4.6	-0.5
Hand grip strength (right)	4.9	13.3	25.5	-5.1	-1.0
Osteoarthritis (self-reported)	4.5	5.9	7.1	2.2	-2.7
Hand grip strength (left)	4.3	11.3	22.3	-4.7	-0.5
Lupus	4.1	6.2	10.5	3.2	-1.4
Hip circumference	4.1	17.5	25.2	-5.0	-3.1
Worrier / anxious feelings	4.1	7.8	13.6	1.4	3.7
Alcohol intake versus 10 years previously	4.0	6.0	7.5	-2.1	2.7
Supplements: Glucosamine	3.9	5.1	10.2	-0.1	-3.2
Serious illness, injury or assault of a close relative in last 2 years	3.9	4.5	8.1	-2.8	-1.0
Blood White Count	3.5	25.8	26.0	-5.1	5.1
Glaucoma (self-reported)	3.5	4.2	8.3	-0.1	2.9
Illness, injury, bereavement, stress in last 2 years	3.5	4.3	6.6	2.6	-1.4
Ulcerative Colitis (UC)	3.4	6.3	12.6	0.0	3.6
Systolic Blood Pressure	3.3	16.4	23.9	4.9	3.0
Respiratory disease	3.3	7.4	13.1	3.6	-1.3
Systolic blood pressure, automated reading	3.3	9.5	14.9	3.9	2.0
Pain all over the body in last month	3.3	3.5	3.8	-2.0	-1.8
Multivitamins +/- minerals	3.2	4.0	6.9	-1.1	-2.6
LDL Cholesterol	3.1	4.9	9.8	3.1	0.4
Medication: Metformin	3.1	4.4	7.2	-2.7	-1.2
Maternal smoking around birth	3.1	4.5	6.3	-1.7	-2.5
Time employed in main current job	3.1	3.6	6.6	2.6	0.7
Tinnitus: Yes, now most or all of the time	3.1	3.7	6.8	-2.6	0.7
High cholesterol (Self-reported)	3.1	5.5	10.7	3.3	0.6
Medication: Seretide 50 evohaler	3.0	3.4	6.8	2.6	-0.1
Migraine (self-reported)	2.8	3.5	6.2	2.5	-0.8
Number of full sisters	2.8	3.4	6.0	-0.9	-2.5
Impedance of whole body	2.8	14.3	22.9	2.4	4.8
Irritable Bowel Disease (IBD)	2.7	6.3	11.9	-0.9	3.4
Fasting Glucose	2.7	3.2	4.1	-1.5	-2.0
Birth weight	2.7	5.8	11.0	-3.3	-0.7
Pulse rate, automated reading	2.7	8.8	10.7	3.3	2.6
Mother’s age at death	2.7	3.3	6.7	0.1	2.6
Commuting to job workplace: Cycle	2.7	3.2	4.4	-1.5	2.1
Heel T-Score	2.6	20.4	36.2	-6.0	-2.1
Diabetes (mother)	2.6	3.3	6.4	-2.5	-0.3
Prospective memory result	2.6	3.2	4.6	2.1	1.4
Exposure to tobacco smoke at home	2.6	2.9	5.6	-0.4	-2.4
Had major operations	2.6	3.1	6.0	-2.5	-0.4
Wears glasses or contact lenses	2.6	3.0	5.3	0.9	2.3
Basal cell carcinoma (self-reported)	2.6	3.1	5.6	-2.4	0.7
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	8.5	-1.1	2.9
Eye problems/disorders: Glaucoma	2.5	3.0	5.9	-0.3	2.4
HDL Cholesterol	2.4	3.9	7.9	2.8	0.2
Number of operations (self-reported)	2.4	3.6	6.1	-2.5	-1.1
Impedance of leg (right)	2.3	11.3	22.1	0.7	4.7
Impedance of leg (left)	2.3	11.1	20.6	1.2	4.5
Pulse rate	2.3	3.9	4.6	1.8	2.1
Medication: Gliclazide	2.3	2.7	4.0	-2.0	-1.1
Cholesterol lowering medication	2.3	3.3	6.4	2.5	-0.6
Trunk fat mass	2.2	9.6	18.7	-4.3	-0.8
Waist circumference	2.2	8.0	13.9	-3.7	-1.4
Impedance of arm (left)	2.2	10.2	15.2	2.3	3.9
Supplements: Vitamin C	2.2	2.6	5.0	0.5	2.2
Medication: Atorvastatin	2.2	2.7	3.5	1.9	1.4
Alzheimer’s Disease (in mother)	2.1	2.4	3.8	-1.0	1.9
Diabetes (father)	2.1	2.6	3.1	1.5	1.8
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.0	-2.2	0.0
Medication: Simvastatin	2.1	3.1	4.8	2.2	-1.2
Fractured/broken bones in last 5 years	2.1	2.7	5.2	0.3	2.3
Diastolic blood pressure, automated reading	2.1	6.5	12.5	3.5	0.7
Hypothyroidism (self reported)	2.0	4.7	9.1	-0.5	3.0
Sensitivity / hurt feelings	2.0	3.4	5.9	-0.9	2.4
Nervous feelings	2.0	3.7	6.9	2.6	0.7
Loud music exposure frequency	2.0	2.2	3.3	1.0	1.8
Whole body fat mass	2.0	8.4	15.8	-4.0	-1.0
Average weekly champagne plus white wine intake	2.0	2.7	4.5	1.0	2.1
Bipolar Disorder (2011)	1.9	1.8	3.6	-0.1	1.9
Cardiovascular Disease	1.9	6.1	11.0	3.3	1.1
Supplements: Zinc	1.9	2.0	3.9	-0.4	-2.0
Had menopause	1.9	2.3	4.7	-0.1	2.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.4	0.0	-2.1
Comparative body size at age 10	1.9	5.2	10.0	-0.6	-3.2
Number of self-reported non-cancer illnesses	1.9	3.2	5.2	2.3	1.1
Type 2 Diabetes (T2D) (2018)	1.8	3.4	6.8	-2.6	-0.1
Lung FVC	1.8	9.1	9.3	-3.0	-3.0
Impedance of arm (right)	1.8	8.5	8.7	2.9	2.9
Pulse wave reflection index	1.8	2.2	4.3	-0.1	-2.1
Medication: Paracetamol	1.8	2.9	3.8	1.4	2.0
Wheeze or whistling in the chest in last year	1.8	3.3	4.7	2.2	-1.4
Medication: Bendroflumethiazide	1.8	2.8	5.5	2.3	-0.3
Worry (Nagel 2018)	1.7	3.7	4.9	1.6	2.2
Leg fat mass (right)	1.7	6.6	11.7	-3.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	4.1	2.0	-0.3
Neuroticism (2016)	1.6	2.3	4.2	2.0	0.6
Primary Biliary Cirrhosis	1.6	2.2	3.1	1.8	-1.2
Rheumatoid Arthritis	1.6	2.2	4.1	-2.0	0.5
Waist Hip Ratio (WHR)	1.6	7.4	14.2	-0.7	3.8
Medication for hormone replacement therapy	1.6	1.7	3.3	-1.8	0.4
Medication: Ventolin 100micrograms inhaler	1.6	2.0	3.3	1.8	-0.8
Diabetes diagnosed by doctor	1.6	2.6	5.1	-2.3	-0.0
Leg fat mass (left)	1.6	6.4	10.6	-3.2	-1.5
Neuroticism (Nagel 2018)	1.5	3.5	5.8	1.1	2.4
Triglycerides	1.5	2.4	3.0	-1.4	-1.7
Noisy workplace	1.5	1.9	3.6	-0.4	-1.9
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.6	-0.3	-1.9
Medication for pain relief, constipation, heartburn	1.5	2.5	3.2	-1.4	-1.8
Illnesses of siblings: Diabetes	1.5	1.9	2.8	-1.7	-1.0
Arm fat mass (left)	1.5	6.0	9.9	-3.1	-1.4
Ulcerative Colitis	1.4	2.0	3.7	-0.5	1.9
Medication: Atenolol	1.4	1.7	2.5	1.0	1.6
Medication: Ramipril	1.4	1.8	3.5	-1.9	-0.4
Happiness	1.4	1.7	3.2	-1.8	0.3
Chest pain or discomfort	1.4	2.0	3.2	-1.8	-0.9
Leg pain on walking	1.4	1.8	3.6	0.2	-1.9
Hearing aid user	1.4	1.6	3.1	1.8	0.4
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.2	-1.5	0.9
Qualifications: CSEs or equivalent	1.3	1.7	3.0	1.7	-0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.0	-1.2	1.4
Length of working week for main job	1.3	1.4	2.2	-0.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	2.7	1.7	0.7
Mineral and other dietary supplements	1.3	1.7	2.2	1.1	1.5
Smoking status: Current	1.3	2.0	4.0	-0.2	-2.0
Medication: Paracetamol	1.3	2.0	2.2	1.5	1.3
Supplements: Calcium	1.3	1.4	2.7	-1.6	0.2
HbA1C	1.2	1.4	2.7	-0.2	1.6
Current tobacco smoking	1.2	1.9	3.8	-0.1	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.6	5.0	-2.2	0.6
Arm fat mass (right)	1.2	5.1	8.0	-2.8	-1.5
Tense / ‘highly strung’	1.2	2.0	3.9	-0.2	2.0
Number of children fathered	1.2	1.4	2.5	-1.6	0.5
Illnesses of father: Heart disease	1.2	1.7	1.8	1.4	1.3
Breast cancer (self-reported)	1.2	1.4	2.4	-0.6	1.6
Reaction Time	1.1	2.1	4.2	2.0	-0.3
Neuroticism	1.1	2.7	3.1	1.8	1.6
Alcohol usually taken with meals	1.1	1.8	3.2	0.6	1.8
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.4	-1.9	-0.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.0	-1.2	-1.4
Worry too long after embarrassment	1.1	1.9	3.3	0.7	1.8
Medication: Blood pressure	1.1	1.9	3.0	0.9	1.7
Medication: Ibuprofen	1.1	1.3	2.1	0.7	1.5
Smoking status: Previous	1.1	1.6	3.1	1.8	-0.4
Ever had bowel cancer screening	1.1	1.3	2.6	-0.2	-1.6
Commuting to job workplace: Walk	1.1	1.2	2.2	0.5	1.5
Pack years of smoking	1.1	1.6	2.1	1.1	-1.5
Verbal and Numeric Reasoning (VNR)	1.0	2.5	3.2	-1.8	-1.3
Blood Platelet Count	1.0	11.1	22.3	-0.0	4.7
Smoking Status	1.0	2.3	3.9	0.8	-2.0
Medication: Co-codamol	1.0	1.1	2.1	0.3	-1.4
Relative age voice broke	1.0	1.5	3.0	-1.7	-0.3
High blood pressure (mother)	1.0	1.4	2.6	0.4	-1.6
Allergy	1.0	2.4	3.8	-2.0	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	1.4	1.0	1.2
Bipolar Disorder (2018)	0.9	1.4	2.9	-0.0	1.7
Bipolar Disorder or Schizophrenia	0.9	2.2	3.6	-0.9	1.9
Age at First Birth	0.9	1.3	2.5	1.6	0.3
Severe depression (siblings)	0.9	1.0	1.2	-0.9	1.1
Pack years adult smoking proportion	0.9	1.4	1.7	1.0	-1.3
Age when periods started (menarche)	0.9	2.1	2.2	1.4	-1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	-1.3	0.7
Lung cancer (father)	0.9	1.0	1.8	-1.3	0.5
Breast Cancer	0.8	1.9	3.4	-0.6	1.9
Crohns Disease (2012)	0.8	1.3	1.3	-1.2	1.1
Fed-up feelings	0.8	1.4	1.6	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.1	0.0	1.4
Medication: Levothyroxine sodium	0.8	1.3	2.5	0.4	1.6
Number of incorrect matches in round	0.8	1.4	1.6	-1.1	1.2
Qualifications: None of the above	0.8	1.8	2.5	1.6	1.1
Neuroticism score	0.8	1.7	2.7	0.8	1.6
Hair/balding pattern: Pattern 4	0.8	1.9	3.4	-1.9	0.6
Health satisfaction	0.8	1.1	1.6	-0.8	-1.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.5	0.7	-1.2
Back pain experienced in last month	0.8	1.1	1.6	-1.2	0.8
Medication: Lisinopril	0.8	1.0	1.1	1.0	-1.0
Alcohol drinker status: Never	0.8	1.0	1.1	-1.1	0.9
Average weekly beer plus cider intake	0.8	1.2	1.5	-1.2	-0.9
Ever depressed for a whole week	0.8	1.0	1.6	-1.3	0.7
Alzheimer’s Disease (in father)	0.7	0.8	1.6	-1.2	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-1.4	0.3
Crohns Disease (2017)	0.7	1.4	2.3	-0.7	1.5
Number of treatments/medications taken	0.7	1.3	1.6	1.2	1.0
Relative age of first facial hair	0.7	1.5	1.6	-1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.0	-1.4	1.0
Past tobacco smoking	0.7	1.3	1.8	-1.3	0.9
Breastfed as a baby	0.7	0.8	1.4	1.2	0.5
Blood clot in the leg (DVT)	0.7	0.9	1.3	-0.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	0.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	0.9	0.9	0.8
Qualifications: nursing, teaching	0.7	1.1	1.4	-0.9	-1.2
Guilty feelings	0.7	1.0	1.2	0.9	1.1
Financial situation satisfaction	0.7	0.9	1.0	-1.0	0.9
Age started oral contraceptive pill	0.7	0.9	1.2	1.1	0.8
Depression (Nagel 2018)	0.6	1.0	1.8	-0.4	1.3
Schizophrenia (2018)	0.6	1.3	1.5	-1.2	1.1
Major Depression (MDD)	0.6	0.8	0.8	0.9	-0.8
BMI	0.6	3.6	6.4	-0.9	-2.5
Average weekly spirits intake	0.6	0.8	1.2	0.6	-1.1
Average weekly fortified wine intake	0.6	0.8	0.9	0.8	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	-1.1	0.2
Medication: Cholesterol lowering	0.6	0.9	1.8	1.3	0.2
Medication: Amlodipine	0.6	0.9	1.4	-0.6	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.9	0.9	0.8
Average weekly red wine intake	0.6	0.9	1.7	0.3	1.3
Loneliness, isolation	0.6	0.9	1.7	1.3	0.3
Illnesses of father: High blood pressure	0.6	0.8	1.6	-0.0	-1.3
Ever smoked	0.6	1.1	2.1	0.3	-1.5
Myopia	0.6	0.9	1.9	1.4	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.4	-1.5	-0.8
Alcohol drinker status: Previous	0.6	0.7	0.9	1.0	-0.7
Depressed Affect (Nagel 2018)	0.5	1.1	1.3	1.0	1.1
Mean Putamen Volume	0.5	0.6	1.2	0.2	1.1
Blood Red Count	0.5	4.7	9.1	-0.6	-3.0
Hair Pigment	0.5	12.9	19.6	-4.4	2.5
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	-0.3	1.0
Financial difficulties in last 2 years	0.5	0.7	0.9	-0.7	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	-1.1	0.6
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	-0.3	1.1
Ever highly irritable/argumentative for 2 days	0.5	0.7	0.9	-0.9	0.7
Age at first live birth	0.5	0.9	1.7	1.3	0.3
Mean time to correctly identify matches	0.5	1.0	1.3	0.8	-1.2
Overall health rating	0.5	1.0	2.0	-0.1	-1.4
Mood swings	0.5	0.9	1.1	0.8	1.0
Risk taking	0.5	0.7	1.5	-0.1	-1.2
Unable to work because of sickness or disability	0.5	0.6	0.7	0.9	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.3	0.2	1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.0	-0.6	1.0
Allergy or Eczema	0.4	1.2	2.1	1.5	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.7	-0.7	0.8
High blood pressure	0.4	1.2	1.5	1.2	0.9
Body mass index (BMI)	0.4	1.5	2.8	-0.6	-1.7
Had other major operations	0.4	0.5	0.9	-0.4	0.9
Heart attack	0.4	0.6	1.1	0.2	1.1
Diabetes (self-reported)	0.4	0.5	1.0	-1.0	-0.3
Falls in the last year	0.4	0.5	0.8	0.4	-0.9
Medication: Lansoprazole	0.4	0.4	0.8	-0.1	0.9
Family relationship satisfaction	0.4	0.5	0.8	-0.9	-0.3
Hypertension (Self-reported)	0.4	1.0	1.7	1.3	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	0.8	-0.9	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.6	0.5	-0.8
Ovarian Cancer	0.3	0.5	0.5	0.6	0.7
Trunk fat percentage	0.3	1.2	1.4	-1.2	1.0
Fluid intelligence score	0.3	0.6	1.0	-1.0	0.3
Depression (self-reported)	0.3	0.4	0.8	-0.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.8	0.5
Gout (self-reported)	0.3	0.4	0.4	0.7	0.6
High blood pressure (siblings)	0.3	0.4	0.6	-0.5	0.8
Exposure to tobacco smoke outside home	0.3	0.3	0.4	-0.5	0.6
Number of full brothers	0.3	0.3	0.3	0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.7	0.2
Shortness of breath walking on level ground	0.3	0.4	0.6	0.4	-0.8
Knee pain experienced in last month	0.3	0.5	1.0	1.0	-0.1
Long-standing illness, disability or infirmity	0.3	0.5	0.7	0.9	0.5
Eye problems/disorders: Cataract	0.3	0.3	0.6	0.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.5	0.7	0.7
Ever taken oral contraceptive pill	0.3	0.4	0.7	-0.9	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.4	-0.4	0.6
Heart disease (siblings)	0.3	0.4	0.7	0.8	0.4
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	-1.0	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	-0.1
Chronotype (morning person)	0.2	0.4	0.7	0.8	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.3	0.5
Vitamin and mineral supplements	0.2	0.2	0.5	0.0	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.1	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	1.0	-0.0
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	0.2	-0.7
Number of live births	0.2	0.3	0.3	0.6	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	0.5	0.7	-0.5
Body fat percentage	0.2	0.6	1.0	-0.5	1.0
Pulse wave peak to peak time	0.2	0.2	0.3	-0.5	0.2
Emphysema/chronic bronchitis	0.2	0.3	0.5	0.2	-0.7
Alcohol intake frequency.	0.2	0.4	0.4	-0.7	0.6
Suffer from ‘nerves’	0.2	0.3	0.5	0.3	0.7
Age at last live birth	0.2	0.3	0.6	-0.0	0.8
Medication: Aspirin	0.2	0.3	0.5	0.2	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.2	0.4	-0.4
Miserableness	0.2	0.4	0.5	-0.4	0.7
Irritability	0.2	0.4	0.4	0.5	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	0.5	0.3
Schizophrenia vs Biploar Disorder	0.1	0.2	0.2	0.3	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.3
Schizophrenia (2014)	0.1	0.3	0.3	-0.4	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	0.2
Tanning	0.1	1.8	2.7	1.0	-1.6
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.5	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.1	-0.4
Angina	0.1	0.1	0.2	-0.1	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.2	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.2	0.4	0.5
Mouth/teeth dental problems	0.1	0.2	0.2	-0.4	0.3
Illnesses of siblings	0.1	0.1	0.2	0.1	0.4
Arm fat percentage (right)	0.1	0.5	0.9	1.0	-0.3
Father’s age at death	0.1	0.2	0.3	0.2	0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	-0.7	0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.4	-0.4
Headache pain in last month	0.1	0.2	0.2	0.5	0.3
Qualifications: College or University degree	0.1	0.3	0.5	-0.7	-0.3
Eye problems/disorders: None of the above	0.1	0.2	0.2	0.4	-0.4
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.5	-0.3
Angina (self-reported)	0.1	0.1	0.2	-0.1	0.5
Heart disease (mother)	0.1	0.1	0.2	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	-0.2
Arm fat percentage (left)	0.1	0.2	0.4	0.7	0.1
Friendships satisfaction	0.1	0.1	0.1	0.2	0.3
Medication: Blood pressure	0.1	0.2	0.3	0.2	-0.5
Leg fat percentage (left)	0.1	0.3	0.7	0.8	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.0	0.5
Pain experienced in last month	0.1	0.2	0.3	-0.4	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.2	-0.1
Taking other prescription medications	0.0	0.0	0.0	0.0	0.2
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	-0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.3	0.1
Illnesses of mother	0.0	0.0	0.1	-0.1	0.3
Leg fat percentage (right)	0.0	0.1	0.2	0.3	0.4
Medication: Allopurinol	0.0	0.0	0.1	0.2	0.1
Medication: Omeprazole	0.0	0.1	0.1	0.2	0.3
Medication for cholesterol	0.0	0.0	0.0	0.1	0.2
Osteoporosis (self-reported)	0.0	0.0	0.1	0.2	-0.1
Medication: Aspirin	0.0	0.0	0.0	0.2	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.1	-0.2

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