Best TWAS P=9.07e-20 · Best GWAS P=6.94e-23 conditioned to 0.00205
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SKAP2 | 0.12 | 0.08 | lasso | 1 | 0.08 | 1.7e-09 | 5.4 | -5.4 | 6.9e-08 | 0.02 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | AC004540.4 | 0.15 | 0.00 | enet | 29 | 0.03 | 1.5e-02 | 3.5 | 5.8 | 6.8e-09 | -0.01 | 0.13 | 0.09 | TRUE |
| 3 | METSIM | Adipose | HOXA4 | 0.04 | 0.02 | blup | 391 | 0.02 | 8.3e-04 | 5.5 | 5.8 | 5.7e-09 | -0.03 | 0.31 | 0.62 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SKAP2 | 0.15 | 0.14 | bslmm | 626 | 0.14 | 4.0e-17 | 5.6 | -6.8 | 1.5e-11 | 0.04 | 0.96 | 0.04 | TRUE |
| 5 | YFS | Blood | SKAP2 | 0.57 | 0.62 | bslmm | 639 | 0.64 | 4.0e-285 | -4.5 | 5.4 | 6.5e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA0087 | 0.13 | 0.02 | enet | 24 | 0.06 | 3.5e-13 | 2.0 | 5.5 | 3.0e-08 | -0.08 | 0.93 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | JAZF1 | 0.12 | 0.09 | lasso | 4 | 0.09 | 2.1e-09 | -8.7 | -9.1 | 9.1e-20 | 0.82 | 0.03 | 0.97 | TRUE |