Hub : Genes

AC004540.4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.230 0.0540 9.3e-06 0.186 NA 0.139 NA 0.176 4.2e-15 NA 2.0e-11 NA 2.8e-14
2 GTEx Adipose Visceral Omentum 0.150 0.0620 9.8e-03 -0.004 NA 0.027 NA 0.005 5.7e-01 NA 1.5e-02 NA 1.6e-01
3 GTEx Brain Cortex 0.278 0.0940 6.8e-03 0.179 NA 0.011 NA 0.131 1.2e-05 NA 1.5e-01 NA 1.8e-04
4 GTEx Pancreas 0.238 0.0810 2.7e-03 0.033 NA 0.063 NA 0.046 1.5e-02 NA 1.2e-03 NA 5.0e-03
5 GTEx Prostate 0.315 0.1230 8.2e-03 -0.011 NA -0.001 NA -0.012 7.5e-01 NA 3.5e-01 NA 8.7e-01
6 GTEx Testis 0.227 0.0750 4.7e-03 0.038 NA 0.035 NA 0.004 8.2e-03 NA 1.1e-02 NA 2.1e-01
7 ROSMAP Brain Pre-frontal Cortex 0.308 0.0417 0.0e+00 0.268 0.165 0.286 0.271 0.285 2.3e-34 1.1e-20 4.5e-37 7e-35 7.1e-37

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 1.2 -0.5 0.2 1.1 0.5 0.0 -0.1 0.8
Bipolar Disorder or Schizophrenia 0.0 0.1 0.3 -0.1 -0.2 -0.5 -0.5 0.0 -0.2 -0.4
Depressed Affect (Nagel 2018) 0.3 0.7 3.2 -0.9 -1.0 0.1 -0.0 0.0 -1.8 0.2
Depression (Nagel 2018) 0.1 0.1 0.2 -0.3 0.3 0.2 -0.4 0.0 -0.3 0.3
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.8 -1.3 -0.8 -1.4 -1.1 0.0 0.5 -1.3
Neuroticism (Nagel 2018) 0.2 0.4 1.3 -0.4 -0.5 0.9 0.1 0.0 -1.1 0.6
Schizophrenia (2018) 0.3 0.7 2.4 0.2 -0.4 -1.5 -1.0 0.0 -0.1 -1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 1.7 0.5 -1.0 -1.3 0.3 0.0 0.1 -0.9
Worry (Nagel 2018) 0.1 0.3 1.0 -0.1 -1.0 0.7 0.4 0.0 -0.4 0.2
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 -1.2 -0.9 -0.8 -0.4 0.0 0.0 -1.3
Alzheimer’s Disease (in father) 0.3 0.3 0.8 0.2 -0.2 -0.6 -0.8 0.0 0.9 -0.5
Alzheimer’s Disease (including proxy) 0.9 1.2 3.5 -0.5 -0.4 -1.2 -1.9 0.0 1.0 -1.5
Crohns Disease (2017) 0.4 0.8 2.8 0.1 -0.3 0.3 1.7 0.0 1.5 0.7
Irritable Bowel Disease (IBD) 0.3 0.7 2.8 0.3 1.0 0.4 0.9 0.0 1.7 0.5
Ulcerative Colitis (UC) 0.2 0.4 1.5 0.1 1.2 -0.2 -0.0 0.0 1.0 -0.5
Major Depression (MDD) 2.2 2.7 7.8 -2.6 -1.6 -1.0 0.1 0.0 -2.8 -1.1
Reaction Time 0.4 0.8 2.3 -1.4 0.6 0.1 -0.9 0.0 -1.5 -0.3
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.5 -0.5 -0.5 -1.1 0.0 0.0 1.2 -0.7
Breast Cancer 0.3 0.8 1.9 -1.1 -0.4 -0.8 1.4 0.0 -1.1 -0.8
Ovarian Cancer 1.6 2.1 10.2 -0.4 0.4 1.2 3.2 0.0 -0.4 1.6
Prostate Cancer 0.9 1.2 2.3 -1.1 -1.5 -0.6 -1.5 0.0 -1.2 -1.1
Age at First Birth 0.3 0.4 1.9 0.5 1.4 -0.0 -0.4 0.0 0.7 -0.2
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.3 0.1 0.5 -0.3 0.0 -0.5 0.3
Body Mass Index (BMI) (2010) 0.4 0.5 1.9 -0.2 -1.0 0.2 1.4 0.0 -0.2 0.7
Coronary Artery Disease (CAD) 2.4 2.8 7.3 -2.0 -2.7 -0.8 0.3 0.0 -2.6 -0.8
Crohns Disease (2012) 0.2 0.4 1.1 0.0 -0.1 0.2 1.0 0.0 1.0 0.6
Mean Putamen Volume 0.3 0.3 1.3 -0.7 -0.2 0.4 -0.0 0.0 -1.1 0.5
Fasting Glucose 1.1 1.3 3.3 0.0 -0.5 -1.7 -1.8 0.0 0.7 -1.4
HbA1C 0.6 0.7 1.8 -0.5 -0.5 -1.4 -0.9 0.0 0.4 -1.1
HDL Cholesterol 3.2 5.3 15.8 4.0 3.1 1.8 0.5 0.0 2.5 1.4
LDL Cholesterol 0.4 0.6 1.6 1.3 0.6 -0.0 -1.0 0.0 1.0 0.6
Lupus 0.6 1.0 2.0 0.7 0.2 1.2 1.1 0.0 1.3 1.4
Neuroticism (2016) 0.1 0.1 0.2 0.4 -0.3 0.3 -0.1 0.0 0.3 0.5
Primary Biliary Cirrhosis 0.6 0.8 2.0 0.3 1.3 0.9 -1.4 0.0 -0.5 0.9
Rheumatoid Arthritis 0.2 0.3 0.6 0.4 -0.5 0.3 0.8 0.0 -0.8 0.5
Schizophrenia (2014) 0.1 0.3 1.1 0.5 -0.2 -1.0 -0.4 0.0 0.1 -0.6
Triglycerides 1.7 2.8 11.8 -3.4 -0.9 -0.2 0.4 0.0 -2.6 0.0
Type 2 Diabetes (T2D) (2012) 2.0 2.3 7.8 -2.8 -0.5 -0.1 0.6 0.0 -2.8 0.1
Ulcerative Colitis 0.5 0.8 4.8 0.0 2.2 0.3 -0.6 0.0 0.5 0.1
Blood Eosinophil Count 1.0 7.7 15.1 -2.5 -2.0 -2.8 -3.9 0.0 -3.0 -3.4
Blood Platelet Count 0.1 0.9 5.6 0.1 -0.1 -0.5 -2.4 0.0 -0.0 -0.8
Blood Red Count 0.5 5.2 11.5 -3.4 -3.1 -1.3 -0.3 0.0 -3.2 -1.7
Blood White Count 0.6 4.7 7.9 -2.6 -2.8 -2.4 -1.6 0.0 -2.0 -2.5
Heel T-Score 0.2 1.2 3.1 1.1 -0.6 -1.3 1.8 0.0 1.3 0.6
BMI 0.8 4.9 14.3 -2.1 -3.8 -2.5 -0.4 0.0 -1.8 -2.4
Height 0.2 3.8 11.6 -3.0 -3.4 -0.4 1.3 0.0 -1.9 -0.4
Waist Hip Ratio (WHR) 14.4 64.6 193.2 -13.9 -7.1 -4.4 1.8 0.0 -12.9 -4.4
Systolic Blood Pressure 1.2 6.2 20.5 -4.5 -2.1 -0.1 0.3 0.0 -4.2 -0.5
Smoking Status 0.3 0.7 2.6 -0.4 -1.3 -0.1 -0.7 0.0 -1.6 -0.1
Allergy or Eczema 0.2 0.5 1.1 0.2 0.7 0.5 0.8 0.0 0.9 1.1
Cardiovascular Disease 1.9 6.3 18.2 -4.3 -2.8 -1.4 -0.3 0.0 -3.6 -1.8
Hypothyroidism (self reported) 0.2 0.5 1.7 -0.0 -0.4 -0.8 -1.3 0.0 0.3 -1.0
Respiratory disease 0.1 0.3 0.6 -0.7 -0.2 0.4 0.3 0.0 -0.8 0.7
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.2 -1.5 -0.9 -1.1 -0.1 0.0 -0.4 -1.1
Lung FEV1/FVC ratio 1.1 5.4 9.9 -2.9 -2.5 -2.9 -1.2 0.0 -1.9 -3.1
Lung FVC 1.7 8.6 33.6 0.7 5.8 3.6 -1.3 0.0 -0.8 3.3
Neuroticism 0.6 1.5 4.3 -1.5 -1.7 0.6 0.5 0.0 -2.1 0.5
Chronotype (morning person) 1.3 3.1 6.9 2.3 1.3 1.8 -1.5 0.0 2.6 1.6
Hair Pigment 0.1 4.0 12.2 3.4 0.9 1.2 0.2 0.0 3.5 1.4
Tanning 0.2 2.9 7.4 2.7 2.1 1.8 0.7 0.0 1.4 1.7
Hand grip strength (left) 0.5 1.2 2.4 -1.0 -0.0 0.9 1.5 0.0 -1.6 1.4
Number of treatments/medications taken 2.8 5.1 12.5 -3.5 -2.9 -1.1 -0.3 0.0 -3.5 -1.2
Average weekly spirits intake 0.3 0.4 1.0 -0.1 -0.4 -0.8 -1.0 0.0 -0.6 -0.9
Sensitivity / hurt feelings 1.2 2.0 3.1 1.4 1.8 1.8 1.1 0.0 1.3 1.8
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 0.4 -0.2 0.0 0.5 0.0 -0.2 0.3
Hearing difficulty/problems: Yes 0.5 0.7 2.7 0.1 -0.5 -0.9 1.6 0.0 1.0 -0.6
Relative age of first facial hair 1.1 2.2 5.1 2.3 1.6 -0.2 -1.8 0.0 2.0 -0.7
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 3.1 -1.8 -0.9 -1.4 -0.2 0.0 -0.3 -1.3
Ever used hormone-replacement therapy (HRT) 0.4 0.4 1.2 -0.8 -0.2 0.6 0.9 0.0 -1.1 0.5
Ever had hysterectomy (womb removed) 0.8 0.9 2.4 -1.6 -0.6 0.2 -1.3 0.0 -1.4 0.0
Systolic blood pressure, automated reading 0.6 1.8 4.2 -1.9 -2.1 0.8 0.9 0.0 -1.8 0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.5 0.9 0.4 0.9 -0.2 0.0 1.2 1.1
Angina 1.1 1.4 5.7 -0.9 -2.4 -0.9 -0.8 0.0 -0.7 -1.1
Medication for hormone replacement therapy 2.1 2.4 5.9 -1.7 -0.1 1.8 1.2 0.0 -2.4 1.8
Vitamin and mineral supplements 0.4 0.6 2.4 -0.5 -1.0 -0.1 1.5 0.0 0.3 -0.4
Supplements: Zinc 0.2 0.2 0.9 0.9 -0.2 -0.5 0.3 0.0 0.5 -0.3
Medication: Co-codamol 0.7 0.8 3.1 -0.0 -1.8 -0.7 -1.4 0.0 0.0 -0.4
Medication: Metformin 1.4 2.0 4.6 -2.2 -1.9 -0.5 1.8 0.0 -1.5 -0.4
Diabetes (father) 0.8 1.0 2.6 -1.6 -1.1 0.2 -0.6 0.0 -1.6 0.5
Diabetes (mother) 0.2 0.2 0.6 -0.8 -0.2 0.0 -0.8 0.0 -0.4 0.1
Severe depression (siblings) 0.6 0.7 2.2 -0.8 -1.5 0.0 0.4 0.0 -1.2 0.4
Pack years adult smoking proportion 0.4 0.7 2.2 -0.4 -0.1 1.5 0.8 0.0 -0.9 1.0
Impedance of leg (right) 0.2 0.9 5.1 0.9 2.3 0.4 -0.2 0.0 0.7 0.2
Leg fat-free mass (left) 0.8 4.5 18.2 -2.5 -4.3 -1.5 0.2 0.0 -1.8 -1.2
Trunk fat percentage 0.6 2.3 11.2 -1.3 -3.3 -0.9 1.4 0.0 -0.7 -0.6
Hand grip strength (right) 0.4 1.1 2.1 -1.1 -0.1 0.8 1.4 0.0 -1.5 1.4
Townsend deprivation index at recruitment 0.3 0.4 1.0 -0.2 -0.0 0.9 1.0 0.0 -0.1 1.0
Current tobacco smoking 0.3 0.5 1.0 0.1 -0.9 0.7 1.0 0.0 -0.6 0.7
Average weekly fortified wine intake 3.3 3.8 7.7 -1.8 -1.4 -2.4 -2.8 0.0 -1.3 -2.6
Maternal smoking around birth 0.9 1.3 2.2 -1.2 -1.2 -0.9 -1.5 0.0 -1.0 -1.5
Fed-up feelings 0.3 0.5 2.9 -0.3 -0.6 -0.1 0.2 0.0 -1.7 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.4 -0.6 0.6 -0.2 -0.5 0.0 -0.4 -0.1
Relative age voice broke 0.7 1.0 3.5 -0.4 -0.3 -1.7 -0.3 0.0 -0.6 -1.9
Taking other prescription medications 3.2 4.9 13.7 -3.7 -2.7 -0.3 -0.3 0.0 -3.7 -0.0
Age when periods started (menarche) 1.1 2.7 6.7 2.5 2.6 1.5 -0.6 0.0 1.7 0.8
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 4.1 -2.0 -0.2 0.2 0.5 0.0 -1.7 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.6 1.6 0.3 -0.1 0.6 0.0 1.4 1.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.4 1.0 1.0 1.2 -0.1 0.0 0.2 0.8
Qualifications: CSEs or equivalent 0.8 1.1 3.2 1.7 0.9 0.5 0.5 0.0 1.8 0.1
Serious illness, injury or assault to yourself 3.5 4.2 12.3 -1.8 -3.5 -2.4 1.8 0.0 -1.1 -2.0
High blood pressure 2.6 7.2 21.7 -4.7 -3.4 -1.2 0.2 0.0 -3.5 -1.7
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.4 -0.2 0.1 -0.0 -0.2 0.0 0.7 0.3
Multivitamins +/- minerals 0.6 0.7 3.4 0.8 0.8 0.3 -1.9 0.0 0.0 0.5
Stomach or abdominal pain in last month 2.0 2.5 6.1 -2.1 -2.2 -1.1 -0.1 0.0 -2.5 -0.8
Supplements: Glucosamine 0.8 1.0 3.2 -1.8 0.3 -0.5 0.4 0.0 -1.7 -0.5
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.3 0.2 0.1 -0.5 0.0 0.4 -0.0
Medication: Atenolol 0.4 0.5 1.2 -0.7 -1.1 1.1 -0.5 0.0 -0.2 0.4
Medication: Levothyroxine sodium 0.3 0.6 1.3 -1.2 0.0 0.4 -1.1 0.0 -1.1 0.1
Sitting height 0.1 0.9 2.7 -1.5 -0.8 -0.4 1.6 0.0 -0.9 -0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.7 0.6 -0.2 0.4 0.3 0.0 0.8 0.4
High blood pressure (mother) 0.1 0.1 0.5 -0.7 -0.4 -0.2 -0.3 0.0 0.0 -0.2
Body mass index (BMI) 0.6 2.5 12.0 -1.6 -3.5 -0.9 -0.1 0.0 -1.1 -0.8
Impedance of leg (left) 0.1 0.7 3.8 0.6 2.0 0.5 0.4 0.0 0.2 0.4
Leg predicted mass (left) 0.9 4.6 18.7 -2.5 -4.3 -1.5 0.3 0.0 -1.8 -1.3
Trunk fat mass 0.9 3.7 17.3 -2.0 -4.2 -1.1 1.3 0.0 -1.3 -0.7
Waist circumference 3.1 11.4 29.5 -4.8 -5.4 -2.4 1.1 0.0 -3.8 -2.3
Number of incorrect matches in round 0.7 1.2 4.0 0.8 2.0 1.1 -1.4 0.0 0.4 0.6
Past tobacco smoking 0.1 0.2 0.8 -0.2 0.9 0.0 -0.8 0.0 -0.4 -0.3
Alcohol usually taken with meals 1.3 2.2 7.2 -0.9 -0.9 -2.7 -0.2 0.0 0.8 -2.4
Nervous feelings 0.3 0.6 4.1 -0.1 -0.3 0.4 2.0 0.0 0.0 0.0
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 2.2 -0.4 -0.5 1.0 1.5 0.0 -0.6 0.9
Hearing difficulty/problems with background noise 0.7 1.2 5.2 1.2 -0.2 0.2 2.3 0.0 1.2 0.5
Hair/balding pattern: Pattern 2 2.0 2.6 7.7 0.8 -1.3 -2.8 -0.6 0.0 0.8 -2.6
Had menopause 0.1 0.2 0.4 -0.5 -0.3 0.2 0.5 0.0 -0.7 -0.1
Had other major operations 0.8 1.0 2.5 -0.9 -1.1 -1.6 0.2 0.0 -0.7 -1.2
Forced vital capacity (FVC) 0.4 1.7 3.0 -1.3 1.5 1.6 0.2 0.0 -1.5 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 2.8 0.8 -0.5 -0.4 1.7 0.0 0.6 1.0
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.3 0.6 -0.0 0.8 1.0 0.0 0.4 1.1
Qualifications: None of the above 0.5 1.2 3.8 -0.7 -0.5 1.4 0.8 0.0 -2.0 0.9
Financial difficulties in last 2 years 1.0 1.3 5.1 -0.3 -2.3 -1.5 -0.1 0.0 -0.6 -1.2
Mouth/teeth dental problems 0.4 0.6 2.3 0.5 1.5 -0.2 -1.0 0.0 0.9 -0.3
Heart attack 0.8 1.0 3.5 -1.4 -1.9 0.5 -0.3 0.0 -1.0 0.2
Allergy 0.1 0.2 0.6 0.5 -0.5 -0.4 0.8 0.0 -0.0 -0.5
Pain all over the body in last month 0.7 0.7 1.6 1.2 0.7 0.7 -1.3 0.0 0.6 0.8
Diabetes (self-reported) 1.1 1.7 5.5 -2.3 -2.1 -0.2 0.3 0.0 -1.3 -0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 -1.0 -0.8 -0.4 -0.8 0.0 -0.6 -0.5
Medication: Ramipril 1.7 2.2 6.3 -2.5 -2.0 0.1 1.4 0.0 -1.8 -0.3
Medication: Simvastatin 1.4 2.0 6.5 -2.5 -1.9 -0.5 0.3 0.0 -1.8 -0.8
Fluid intelligence score 0.4 0.8 2.0 -1.1 -1.4 -1.1 -0.9 0.0 0.2 -0.8
Illnesses of siblings 0.1 0.1 0.2 0.4 0.0 -0.4 0.3 0.0 0.2 -0.3
Neuroticism score 0.3 0.7 1.6 -1.1 -1.2 0.0 0.8 0.0 -1.3 0.0
Weight 0.8 4.1 18.7 -2.2 -4.3 -1.3 0.3 0.0 -1.5 -1.1
Impedance of arm (right) 0.3 1.4 3.0 1.7 1.7 0.2 0.9 0.0 1.5 0.7
Arm fat percentage (right) 0.4 1.7 9.2 -1.0 -3.0 -0.8 0.2 0.0 -0.8 -0.5
Trunk fat-free mass 0.8 4.9 16.1 -3.0 -4.0 -1.1 -0.5 0.0 -2.5 -1.2
Hip circumference 0.4 1.7 4.8 1.8 -1.8 0.2 0.6 0.0 2.2 0.5
Time employed in main current job 1.7 2.0 6.5 2.5 1.6 0.1 -0.6 0.0 2.0 -0.1
Alcohol intake versus 10 years previously 0.6 0.9 2.6 -0.9 -1.6 -0.7 -0.0 0.0 -1.3 -1.0
Father’s age at death 0.7 0.9 1.6 1.1 1.2 1.1 -0.6 0.0 0.5 1.2
Worrier / anxious feelings 0.3 0.5 2.0 -0.2 -0.4 1.0 1.4 0.0 -0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.1 -0.5 -0.1 -0.5 0.0 -0.4 0.0
Falls in the last year 0.9 1.2 2.5 -0.7 -1.1 -1.1 -1.6 0.0 -1.0 -1.4
Hair/balding pattern: Pattern 3 0.3 0.5 1.8 -1.1 0.1 -0.3 -0.6 0.0 -1.3 -0.4
Number of live births 1.6 2.3 6.0 1.3 1.5 2.4 1.2 0.0 0.8 2.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.9 -1.6 1.1 1.1 0.0 0.0 -1.7 1.1
Pulse rate 0.9 1.6 4.6 0.7 0.5 1.6 2.1 0.0 0.1 1.8
Happiness 0.4 0.5 1.1 0.5 0.7 1.1 0.7 0.0 -0.0 0.9
Noisy workplace 0.2 0.3 1.3 0.7 0.0 0.3 -1.2 0.0 0.4 0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.6 -0.9 0.2 -1.2 -0.4 0.0 -0.2 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.5 0.7 -1.6 -0.8 0.2 0.0 1.3 -0.5
Mouth/teeth dental problems: Dentures 0.5 0.9 1.5 -0.4 -0.9 1.1 1.2 0.0 -1.1 1.1
Asthma 0.3 0.6 1.3 -0.9 0.6 1.0 -0.1 0.0 -0.8 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.8 1.5 1.0 -0.0 -0.1 0.0 2.0 -0.1
Medication: Cholesterol lowering 0.8 1.3 2.9 -1.7 -0.8 0.8 1.4 0.0 -1.3 0.9
Depression (self-reported) 0.4 0.4 1.2 0.2 -0.9 -1.1 -0.3 0.0 -0.4 -0.8
Medication: Lansoprazole 0.3 0.4 0.9 -0.9 -0.5 0.5 -0.7 0.0 -0.8 0.2
Prospective memory result 0.4 0.4 1.4 -0.6 0.7 0.3 1.2 0.0 -0.8 0.0
Lung cancer (father) 0.2 0.3 1.0 -0.4 0.5 -0.7 -0.2 0.0 -0.2 -1.0
Illnesses of mother 2.4 2.9 6.9 2.6 2.6 0.9 -1.2 0.0 1.9 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 2.5 -0.9 1.6 1.4 -0.4 0.0 -1.3 1.3
Pulse wave Arterial Stiffness index 0.2 0.2 0.6 0.8 -0.2 0.4 -0.3 0.0 0.7 0.4
Impedance of arm (left) 0.2 1.0 2.3 1.4 1.5 -0.2 1.0 0.0 1.4 0.2
Arm fat mass (right) 0.7 3.1 15.6 -1.5 -4.0 -1.3 0.4 0.0 -1.0 -0.9
Trunk predicted mass 0.9 4.9 15.9 -3.0 -4.0 -1.2 -0.5 0.0 -2.5 -1.3
Standing height 0.2 2.0 5.6 -2.0 -2.4 -1.1 0.9 0.0 -1.4 -0.9
Length of working week for main job 1.0 1.1 4.5 -1.0 -2.1 -0.8 -0.2 0.0 -0.8 -1.0
Exposure to tobacco smoke at home 0.8 0.9 3.1 -0.8 -1.8 -0.7 0.8 0.0 -1.0 -0.5
Breastfed as a baby 0.3 0.3 0.8 0.8 -0.4 0.6 0.9 0.0 0.4 0.5
Tense / ‘highly strung’ 0.6 0.9 1.4 1.2 -0.9 1.1 0.6 0.0 1.2 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.6 -0.6 -1.3 -0.1 0.9 0.0 -0.7 0.3
Hair/balding pattern: Pattern 4 0.2 0.4 1.1 0.3 -0.5 1.0 0.7 0.0 0.2 1.0
Birth weight of first child 2.9 5.2 7.9 -2.3 -2.4 -2.8 -1.8 0.0 -2.6 -2.7
Peak expiratory flow (PEF) 0.4 0.9 1.7 -1.3 0.1 0.6 1.2 0.0 -1.3 1.0
Pulse wave reflection index 0.4 0.5 2.9 -0.1 -0.2 -0.3 -1.7 0.0 -0.1 -0.4
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 0.6 -0.1 0.4 0.8 0.0 0.3 0.4
Loud music exposure frequency 1.8 2.0 5.2 -2.0 -1.2 -1.3 -0.4 0.0 -2.3 -1.2
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 5.2 1.2 0.8 -1.0 -1.4 0.0 2.3 -0.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.9 -0.8 -0.9 0.4 0.0 0.5 -0.9
Blood clot in the leg (DVT) 0.2 0.2 0.8 0.9 -0.3 -0.4 0.1 0.0 0.6 -0.2
Medication: Paracetamol 0.1 0.1 0.5 0.2 -0.2 0.2 -0.2 0.0 0.7 0.0
Headache pain in last month 0.5 0.9 2.3 -0.8 -0.1 -1.4 0.4 0.0 -1.5 -1.1
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 8.0 2.8 1.8 -1.0 -1.4 0.0 2.5 -0.5
Glaucoma (self-reported) 0.3 0.4 1.0 0.8 0.5 0.5 -0.2 0.0 1.0 0.5
Gout (self-reported) 0.2 0.3 0.9 -0.5 -1.0 -0.8 -0.3 0.0 -0.2 -0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.1 -0.6 -0.5 -0.7 -1.1 0.0 -0.5 -0.9
Medication: Amlodipine 4.6 6.4 14.5 -3.8 -3.4 -0.5 2.3 0.0 -3.6 -0.8
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.1 -0.6 1.1 1.4 0.3 0.0 -0.9 1.3
Birth weight 0.1 0.3 0.9 -0.2 -1.0 -0.7 -0.2 0.0 -0.3 -0.5
Chronic bronchitis/emphysema (mother) 1.6 1.9 5.7 -1.7 -1.8 -0.3 2.4 0.0 -1.1 -0.2
High blood pressure (siblings) 0.2 0.3 1.0 0.2 1.0 0.7 -0.4 0.0 0.4 0.6
Forced vital capacity (FVC), Best measure 0.5 2.0 4.2 -0.6 1.9 2.1 0.2 0.0 -1.2 2.0
Body fat percentage 0.5 1.9 9.9 -1.2 -3.1 -0.9 0.7 0.0 -0.8 -0.6
Leg fat percentage (right) 0.3 1.2 5.5 -1.0 -2.3 -0.7 -0.5 0.0 -0.8 -0.7
Arm fat-free mass (right) 0.7 3.6 13.7 -2.5 -3.7 -0.9 0.2 0.0 -1.8 -1.1
Exposure to tobacco smoke outside home 0.3 0.4 1.3 -0.5 -0.1 -0.8 0.3 0.0 -0.6 -1.1
Comparative body size at age 10 2.0 5.6 16.9 -4.1 -2.3 -0.6 1.6 0.0 -3.6 -0.7
Number of full brothers 0.5 0.7 2.2 -0.6 -0.2 1.2 0.3 0.0 -0.8 1.5
Worry too long after embarrassment 0.2 0.3 1.7 -0.4 1.3 0.4 -0.2 0.0 0.4 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.7 -1.2 -1.3 -0.6 0.5 0.0 -0.9 -0.4
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 -0.1 -0.4 1.0 0.8 0.0 0.1 1.1
Number of children fathered 0.2 0.2 0.4 0.6 0.1 0.1 0.7 0.0 0.6 0.1
Reason for reducing amount of alcohol drunk: Health precaution 2.2 2.5 8.6 2.4 1.0 1.0 0.2 0.0 2.9 1.0
Age at first live birth 0.5 0.9 3.2 -1.0 0.5 -0.8 -1.8 0.0 -0.5 -0.9
Pulse wave peak to peak time 0.2 0.3 0.8 -0.9 -0.0 -0.5 0.2 0.0 -0.9 -0.4
Health satisfaction 0.5 0.7 2.4 -0.7 -1.5 0.4 -0.1 0.0 -1.3 0.4
Shortness of breath walking on level ground 0.3 0.4 1.3 0.1 -0.6 0.7 0.3 0.0 -0.4 1.1
Qualifications: College or University degree 0.1 0.2 0.8 -0.9 0.3 -0.5 -0.4 0.0 0.4 -0.1
Eye problems/disorders: None of the above 0.1 0.1 0.4 0.5 0.0 -0.3 -0.4 0.0 0.6 -0.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.7 0.5 -1.2 -0.3 1.3 0.0 0.7 -0.3
Emphysema/chronic bronchitis 0.6 0.7 1.9 1.4 0.5 0.4 -0.9 0.0 1.1 0.6
Medication for pain relief, constipation, heartburn 1.0 1.7 4.4 2.1 1.7 1.0 1.0 0.0 1.3 1.0
Neck or shoulder pain in last month 0.2 0.3 1.6 0.4 -0.2 -0.2 -1.3 0.0 0.6 -0.3
Medication: Blood pressure 2.0 3.4 11.2 -3.3 -1.9 -0.4 1.2 0.0 -2.7 -0.7
Angina (self-reported) 0.9 1.1 4.8 -0.7 -2.2 -0.7 -1.0 0.0 -0.5 -1.0
Migraine (self-reported) 0.2 0.3 0.9 -0.3 -0.5 -0.6 -0.1 0.0 -0.9 -0.4
Medication: Ibuprofen 1.0 1.1 3.7 1.7 0.8 -0.8 0.0 0.0 1.9 -0.6
Medication: Allopurinol 0.2 0.2 0.8 -0.0 -0.9 -0.6 0.3 0.0 0.1 -0.5
Medication: Omeprazole 1.5 1.7 4.6 -1.9 -2.2 -0.7 -0.6 0.0 -1.6 -0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.3 -0.5 -0.3 -0.2 0.0 0.2 -0.3
Mean time to correctly identify matches 0.5 0.9 3.5 -0.7 1.1 -0.2 -1.9 0.0 -0.7 -0.6
Heart disease (mother) 1.6 2.0 4.2 -1.6 -2.0 -1.2 -0.3 0.0 -1.8 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 1.0 -0.4 0.3 -0.3 1.0 0.0 -0.2 -0.2
Whole body fat mass 0.9 3.6 17.0 -2.0 -4.1 -1.0 0.8 0.0 -1.4 -0.7
Leg fat mass (right) 0.8 3.2 13.9 -2.1 -3.7 -1.1 0.1 0.0 -1.5 -0.9
Arm predicted mass (right) 0.9 4.6 16.2 -2.9 -4.0 -1.1 0.2 0.0 -2.2 -1.2
Pulse rate, automated reading 0.1 0.4 1.2 -0.8 0.3 0.0 1.1 0.0 -1.1 0.1
Alcohol intake frequency. 1.1 2.6 5.3 -1.6 -2.3 -1.9 -1.2 0.0 -1.5 -1.9
Comparative height size at age 10 0.8 4.5 11.6 -3.4 -3.0 -1.2 0.3 0.0 -2.8 -1.2
Number of full sisters 1.4 1.7 4.2 2.1 -0.7 1.5 1.3 0.0 1.1 1.6
Suffer from ‘nerves’ 0.3 0.4 1.0 -0.1 -0.9 1.0 0.4 0.0 0.4 0.9
Overall health rating 1.1 2.3 7.6 -1.9 -2.8 -0.2 1.1 0.0 -1.9 -0.4
Chest pain or discomfort 1.0 1.5 6.5 -1.1 -2.5 -1.1 0.4 0.0 -0.1 -1.1
Had major operations 1.0 1.1 4.3 -0.9 -2.1 -1.2 0.2 0.0 -1.0 -0.7
Age at last live birth 0.4 0.6 1.3 0.3 1.1 1.2 -0.6 0.0 0.7 0.6
Family relationship satisfaction 1.0 1.2 3.9 -1.2 -1.2 0.6 2.0 0.0 -1.1 0.6
Leg pain on walking 0.4 0.6 1.6 0.7 -0.9 0.7 0.4 0.0 0.6 1.2
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 5.0 1.8 2.2 -0.5 -2.0 0.0 1.9 -0.8
Commuting to job workplace: Car/motor vehicle 0.8 1.0 3.5 -1.9 -0.0 0.7 -0.4 0.0 -1.6 0.3
Illness, injury, bereavement, stress in last 2 years 2.9 3.5 12.9 1.5 3.6 2.3 -0.1 0.0 1.0 1.8
Medication: Aspirin 4.7 6.3 16.8 -4.0 -2.7 -1.1 -0.6 0.0 -4.1 -1.3
Supplements: Vitamin C 1.9 2.3 5.5 2.3 2.4 0.3 -1.2 0.0 1.9 0.6
Knee pain experienced in last month 0.7 1.0 3.1 1.8 -0.8 0.6 -0.0 0.0 1.7 0.6
Hypertension (Self-reported) 2.3 6.5 21.0 -4.6 -2.9 -1.2 0.1 0.0 -3.4 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 9.7 -3.1 -1.3 -1.1 -0.3 0.0 -2.6 -0.8
Illnesses of father: Heart disease 0.7 1.0 3.4 -0.9 -1.9 -0.1 1.1 0.0 -1.2 0.3
Illnesses of siblings: Diabetes 0.5 0.7 2.5 -0.8 -0.5 -0.6 -1.6 0.0 -0.6 -0.7
Smoking status: Previous 0.0 0.1 0.1 0.4 -0.0 0.2 0.2 0.0 0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.6 -1.1 -1.2 0.3 0.2 0.0 -1.3 0.1
Whole body fat-free mass 0.9 4.9 17.8 -2.8 -4.2 -1.2 -0.1 0.0 -2.3 -1.1
Leg fat-free mass (right) 0.9 4.7 19.4 -2.4 -4.4 -1.5 0.5 0.0 -1.9 -1.2
Arm fat percentage (left) 0.6 2.4 11.4 -1.3 -3.4 -1.3 0.3 0.0 -0.8 -0.9
Average weekly red wine intake 0.4 0.6 2.6 -0.1 0.2 -1.6 -0.0 0.0 0.4 -1.1
Handedness (chirality/laterality): Left-handed 2.9 3.5 10.5 0.9 1.8 3.2 1.5 0.0 0.3 2.8
Mood swings 1.1 2.0 4.9 -1.5 -2.2 -1.1 0.2 0.0 -2.2 -0.9
Loneliness, isolation 0.3 0.5 1.0 -0.6 -0.4 0.9 0.4 0.0 -1.0 1.0
Long-standing illness, disability or infirmity 2.7 4.1 9.9 -2.6 -3.1 -2.4 -0.2 0.0 -1.3 -2.2
Ever had bowel cancer screening 0.2 0.3 0.7 -0.8 0.5 0.6 -0.4 0.0 -0.4 0.4
Diabetes diagnosed by doctor 1.3 2.1 6.4 -2.5 -1.8 -0.9 0.1 0.0 -1.6 -1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 0.6 0.4 0.7 -1.3 0.0 -0.1 0.5
Friendships satisfaction 1.3 1.6 6.8 -0.5 -2.6 -0.7 1.9 0.0 0.1 -0.6
Qualifications: nursing, teaching 0.1 0.2 0.6 -0.7 0.1 -0.4 0.6 0.0 -0.7 0.1
Commuting to job workplace: Walk 0.2 0.2 1.1 1.0 -0.4 -0.1 0.5 0.0 0.1 0.2
Eye problems/disorders: Cataract 0.5 0.6 2.0 -0.8 -0.4 -1.1 0.2 0.0 -0.4 -1.4
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.9 -0.3 -0.2 0.5 0.9 0.0 -0.6 0.7
Medication for cholesterol 2.7 4.1 11.1 3.3 2.5 -0.1 0.5 0.0 3.3 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 7.1 -1.2 -2.7 -2.2 -1.0 0.0 -0.3 -2.4
Back pain experienced in last month 1.3 1.8 5.6 -2.1 -1.6 -0.3 0.4 0.0 -2.4 -0.3
Mineral and other dietary supplements 1.5 2.0 5.2 2.3 -0.0 0.7 1.8 0.0 2.3 0.4
Breast cancer (self-reported) 0.6 0.8 1.5 -0.3 0.2 1.2 1.2 0.0 -1.1 1.0
Asthma (self-reported) 0.3 0.5 1.1 -1.1 0.4 0.7 0.1 0.0 -1.0 0.9
Osteoporosis (self-reported) 0.2 0.2 0.5 0.0 0.6 0.7 -0.5 0.0 0.2 0.6
Osteoarthritis (self-reported) 1.2 1.6 3.8 -0.6 1.2 1.9 0.3 0.0 -1.4 1.9
Medication: Aspirin 4.8 6.3 14.7 -3.8 -2.6 -1.8 -1.0 0.0 -3.8 -1.9
Medication: Gliclazide 1.3 1.5 3.3 -1.8 -1.3 -1.6 -0.1 0.0 -0.8 -1.5
Illnesses of father: None of the above (group 1) 0.8 1.0 2.9 1.7 1.7 0.4 0.2 0.0 1.2 0.3
Smoking status: Current 0.3 0.4 1.2 0.3 -1.0 0.6 1.1 0.0 -0.3 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.4 0.3 1.6 -0.4 -0.1 0.0 0.1 -0.6
Whole body water mass 0.9 4.9 17.6 -2.9 -4.2 -1.3 -0.0 0.0 -2.3 -1.2
Leg predicted mass (right) 0.9 4.6 18.9 -2.5 -4.3 -1.4 0.5 0.0 -2.0 -1.1
Arm fat mass (left) 0.8 3.2 14.9 -1.8 -3.9 -1.3 0.3 0.0 -1.1 -1.0
Number of self-reported non-cancer illnesses 2.9 5.0 13.8 -3.7 -3.0 -1.1 -0.7 0.0 -3.1 -1.0
Average weekly champagne plus white wine intake 0.1 0.1 0.3 -0.4 0.6 -0.2 0.4 0.0 -0.2 -0.4
Miserableness 0.3 0.5 1.0 -0.8 -0.9 -0.6 0.4 0.0 -1.0 -0.4
Guilty feelings 0.2 0.3 0.9 -0.8 -0.3 -0.4 -0.4 0.0 -1.0 -0.2
Wears glasses or contact lenses 1.0 1.1 3.7 -0.3 -0.7 -1.8 0.4 0.0 -0.3 -1.9
Ever taken oral contraceptive pill 0.8 0.9 4.2 0.4 0.0 0.8 -2.1 0.0 -0.6 0.8
Hearing aid user 1.9 2.2 4.0 -1.2 -2.0 -1.9 0.6 0.0 -1.5 -1.8
Mother’s age at death 1.1 1.4 4.9 1.8 0.2 -0.9 -0.1 0.0 2.2 -0.7
Financial situation satisfaction 0.3 0.3 0.8 0.5 -0.5 -0.5 0.1 0.0 0.9 -0.9
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.6 0.6 0.2 1.0 0.4 0.0 0.5 1.3
Commuting to job workplace: Public transport 1.5 1.7 5.6 2.1 1.2 -0.6 -0.6 0.0 2.4 -0.4
Eye problems/disorders: Glaucoma 0.2 0.3 0.5 0.5 -0.1 0.6 -0.6 0.0 0.7 0.6
Medication: Blood pressure 1.7 3.3 9.5 -3.1 -2.6 -0.8 0.1 0.0 -2.0 -1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.7 3.6 -0.4 -1.9 0.2 0.9 0.0 -0.7 0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.1 -1.4 0.1 0.0 -0.9 0.0 -1.5 0.5
High cholesterol (Self-reported) 0.3 0.6 2.5 -0.8 -1.6 -0.3 -0.1 0.0 -0.7 -0.5
Medication: Bendroflumethiazide 1.0 1.5 6.2 -2.5 -0.9 -0.2 0.8 0.0 -1.5 -0.9
Medication: Paracetamol 0.2 0.3 0.8 0.2 -0.9 -0.8 0.1 0.0 0.5 -0.7
Medication: Lisinopril 0.5 0.7 1.4 -1.1 -0.7 1.2 0.7 0.0 -0.5 0.8
Medication: Atorvastatin 0.9 1.1 2.3 -1.5 -1.5 0.7 0.4 0.0 -1.4 0.8
Illnesses of father: High blood pressure 1.2 1.4 4.2 -1.2 -0.6 -1.8 -0.6 0.0 -0.5 -2.0
Alcohol drinker status: Never 2.6 3.1 8.7 0.3 -1.1 -2.8 -2.0 0.0 0.5 -3.0
Ever smoked 0.1 0.2 1.1 -0.1 -0.7 0.1 1.0 0.0 0.0 0.3
Basal metabolic rate 0.9 5.0 19.6 -2.7 -4.4 -1.4 0.1 0.0 -2.1 -1.3
Leg fat percentage (left) 0.4 1.6 7.4 -1.2 -2.7 -0.7 -0.2 0.0 -1.2 -0.6
Arm fat-free mass (left) 0.8 4.0 15.1 -2.6 -3.9 -1.0 -0.2 0.0 -2.1 -1.1
Number of operations (self-reported) 2.0 3.0 8.7 -2.7 -2.0 -0.5 0.5 0.0 -3.0 -0.2
Average weekly beer plus cider intake 0.3 0.5 1.5 0.2 0.2 1.2 -0.1 0.0 -0.9 0.9
Irritability 0.4 0.7 2.2 -0.6 0.1 1.5 0.6 0.0 -1.0 1.2
Risk taking 1.0 1.5 6.1 -0.7 -2.5 -1.5 0.0 0.0 -0.5 -1.1
Ever had prostate specific antigen (PSA) test 1.1 1.3 5.4 -1.5 -0.6 0.3 -0.6 0.0 -2.3 0.7
Fractured/broken bones in last 5 years 0.2 0.2 0.7 0.2 -0.6 0.9 0.3 0.0 -0.4 0.6
Age started oral contraceptive pill 0.2 0.2 0.8 -0.1 0.3 0.9 0.4 0.0 -0.2 0.6
Diastolic blood pressure, automated reading 0.3 1.0 2.2 -1.2 -0.7 1.2 -0.3 0.0 -1.2 1.5
Ever depressed for a whole week 0.0 0.0 0.1 0.2 -0.1 0.2 0.0 0.0 -0.0 0.4
Unable to work because of sickness or disability 0.5 0.6 1.9 -0.7 -1.1 -0.8 -0.2 0.0 -1.4 -0.3
Commuting to job workplace: Cycle 0.8 1.0 3.9 0.3 0.6 -0.8 -2.0 0.0 0.9 -1.0
Myopia 1.4 2.0 4.3 -1.1 -2.1 -1.9 -0.4 0.0 -0.7 -2.1
Vascular/heart problems diagnosed by doctor 3.2 8.7 24.9 5.0 3.9 1.3 -0.3 0.0 3.9 1.9
Cholesterol lowering medication 3.3 4.8 14.6 -2.4 -3.8 -1.6 -0.9 0.0 -2.3 -2.1
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 4.5 -2.1 -2.0 -0.6 -1.1 0.0 -1.6 -0.4
Pain experienced in last month 0.3 0.5 2.0 0.2 0.8 0.7 1.4 0.0 -0.2 0.6
Supplements: Calcium 0.4 0.4 2.2 0.5 0.5 0.2 -1.5 0.0 0.4 -0.2
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 0.3 -1.1 0.3 0.3 0.0 0.0 -0.0
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.8 -1.2 -1.9 0.5 -0.0 0.0 -0.8 0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.7 0.8 -0.0 -0.1 0.1 0.0 0.7 0.0
Heart disease (siblings) 1.0 1.2 3.5 -1.8 -1.3 -0.4 -0.1 0.0 -1.9 0.0
Alcohol drinker status: Previous 0.4 0.4 1.4 0.5 -0.1 1.2 0.0 0.0 0.3 1.1
Pack years of smoking 0.4 0.6 2.1 -0.3 -0.1 1.4 0.8 0.0 -0.6 1.0
Impedance of whole body 0.3 1.5 5.3 1.5 2.3 0.3 0.7 0.0 1.2 0.6
Leg fat mass (left) 0.9 3.6 15.6 -2.2 -3.9 -1.0 0.2 0.0 -1.7 -0.8
Arm predicted mass (left) 0.6 3.3 12.9 -2.3 -3.6 -0.8 -0.2 0.0 -1.9 -0.9