TWAS hub - KIAA0087

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.7720	0.0280	0.0e+00	0.552	0.459	0.538	0.448	0.551	9.9e-81	2.8e-62	8.8e-78	2.4e-60	1.8e-80
2	TCGA	Breast Invasive Carcinoma	0.1296	0.0381	5.4e-10	0.017	0.058	0.065	NA	0.060	1.4e-04	6.2e-12	3.5e-13	NA	2.1e-12
3	TCGA	Brain Lower Grade Glioma	0.0372	0.0195	7.7e-03	0.009	0.020	0.020	NA	0.009	3.2e-02	1.9e-03	2.0e-03	NA	2.7e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	9.2	3.0	2.0	2.4
Had other major operations	3.7	4.5	12.7	3.6	0.9	0.1
Lung FVC	3.4	17.6	30.7	1.1	5.5	4.6
Medication: Ramipril	3.4	4.4	4.8	-2.2	-2.1	-1.9
Impedance of leg (right)	3.3	16.0	40.7	2.7	-0.2	6.4
Tinnitus: Yes, now most or all of the time	3.3	3.8	6.8	2.6	-1.6	1.5
Medication: Metformin	3.1	4.3	7.3	-2.1	-1.1	-2.7
Impedance of leg (left)	2.9	14.2	38.3	2.0	-0.6	6.2
Mean time to correctly identify matches	2.8	5.3	6.5	2.5	1.9	2.4
Illness, injury, bereavement, stress in last 2 years	2.8	3.5	5.1	0.6	2.2	2.3
Leg fat-free mass (right)	2.7	14.6	38.3	-2.2	-0.7	-6.2
Leg predicted mass (right)	2.7	14.2	37.3	-2.2	-0.7	-6.1
Waist circumference	2.6	9.5	21.3	-2.6	-0.5	-4.6
Friendships satisfaction	2.6	3.2	6.5	-2.6	-0.8	-1.6
Body Mass Index (BMI) (2010)	2.5	3.5	5.7	-1.0	-1.9	-2.4
Leg fat-free mass (left)	2.5	13.3	36.0	-1.9	-0.4	-6.0
Leg predicted mass (left)	2.5	13.3	36.0	-2.0	-0.4	-6.0
Commuting to job workplace: Cycle	2.5	3.1	7.2	-0.5	2.7	-1.3
Medication: Cholesterol lowering	2.4	3.7	5.6	-2.4	-1.4	-1.8
Emphysema/chronic bronchitis	2.4	2.7	4.4	2.1	1.8	0.7
Relative age of first facial hair	2.3	4.7	11.6	1.5	0.6	3.4
Medication: Blood pressure	2.3	4.0	6.4	-2.2	-1.0	-2.5
Ever taken oral contraceptive pill	2.3	2.6	6.8	2.6	0.8	0.5
Waist Hip Ratio (WHR)	2.2	9.9	17.9	-4.2	0.4	-3.4
Comparative body size at age 10	2.2	6.1	12.2	-2.4	0.6	-3.5
Diabetes (self-reported)	2.1	3.2	4.0	-2.0	-1.8	-1.6
Medication: Amlodipine	2.1	3.0	3.6	-1.5	-1.9	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	5.6	-1.3	0.2	-2.4
Impedance of whole body	2.1	10.5	29.0	1.6	-0.2	5.4
Diabetes diagnosed by doctor	2.0	3.2	5.0	-2.2	-1.5	-1.5
Nervous feelings	1.9	3.5	8.5	-2.9	-1.4	0.1
Had major operations	1.9	2.2	4.3	1.5	-0.1	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	3.9	0.7	1.3	-2.0
Alcohol drinker status: Never	1.9	2.3	6.5	2.5	0.4	0.4
Serious illness, injury or assault to yourself	1.8	2.2	3.9	-0.6	-2.0	-1.6
Body mass index (BMI)	1.8	7.5	19.0	-1.9	0.0	-4.4
Weight	1.8	8.9	22.1	-1.9	-0.9	-4.7
Arm fat mass (left)	1.8	7.2	18.7	-1.7	-0.2	-4.3
Basal metabolic rate	1.8	10.0	26.5	-1.7	-0.9	-5.2
Depression (Nagel 2018)	1.7	2.6	6.0	2.5	0.8	1.0
Systolic blood pressure, automated reading	1.7	4.9	11.2	-1.4	-1.2	-3.3
Trunk fat mass	1.7	7.4	16.2	-2.2	-1.0	-4.0
Time employed in main current job	1.7	2.0	3.7	1.9	-1.2	0.9
Father’s age at death	1.7	2.3	6.9	0.0	-0.2	2.6
Whole body fat mass	1.7	7.0	15.8	-2.1	-0.9	-4.0
Whole body fat-free mass	1.7	9.9	26.6	-1.6	-0.9	-5.2
Whole body water mass	1.7	9.8	26.0	-1.6	-0.9	-5.1
Schizophrenia (2018)	1.6	3.3	7.6	2.8	1.4	-0.5
Reaction Time	1.6	3.0	4.1	2.0	1.9	1.1
BMI	1.6	9.1	25.2	-1.4	0.1	-5.0
Falls in the last year	1.6	2.2	5.7	1.0	-0.2	2.4
Arm fat mass (right)	1.6	6.7	17.1	-1.7	-0.4	-4.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.2	-0.6	-2.1	-1.1
Medication: Gliclazide	1.6	1.8	3.3	-1.8	-0.4	-1.4
Fasting Glucose	1.5	1.8	3.8	1.9	0.6	1.2
Maternal smoking around birth	1.5	2.2	6.4	2.5	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	2.2	1.3	1.5	1.5
Illnesses of mother	1.5	1.9	2.4	-1.4	1.1	1.5
Arm predicted mass (right)	1.5	7.8	20.1	-1.5	-1.0	-4.5
Leg fat mass (left)	1.5	5.9	14.7	-1.7	-0.3	-3.8
Arm fat percentage (left)	1.4	5.4	13.3	-1.7	0.2	-3.6
Osteoporosis (self-reported)	1.4	1.8	3.6	-0.1	-1.3	1.9
Prostate Cancer	1.3	1.8	5.1	-0.4	0.4	-2.3
Heart attack	1.3	1.7	3.0	-0.1	-1.7	-1.4
Depression (self-reported)	1.3	1.5	3.1	-1.8	0.8	-0.9
Arm fat-free mass (right)	1.3	6.8	17.1	-1.4	-1.0	-4.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	2.7	-0.6	-1.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	8.5	-0.2	0.0	2.9
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.2	-0.1	-1.8	-1.3
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.5	0.9	-0.5	1.9
Angina	1.2	1.6	3.7	-0.7	-0.8	-1.9
Had menopause	1.2	1.5	2.6	1.0	1.0	1.6
Fluid intelligence score	1.2	2.6	5.0	-0.9	-2.2	-1.4
Arm fat percentage (right)	1.2	4.8	12.5	-1.3	0.3	-3.5
Trunk fat-free mass	1.2	6.9	18.7	-1.0	-1.0	-4.3
Alcohol intake versus 10 years previously	1.2	1.9	2.5	-0.9	-1.6	-1.5
Trunk predicted mass	1.2	6.7	18.0	-1.1	-0.9	-4.2
Leg fat mass (right)	1.2	4.5	11.9	-1.2	-0.2	-3.4
Medication: Aspirin	1.2	1.6	4.1	-0.3	-0.8	-2.0
Medication: Aspirin	1.2	1.5	3.5	0.0	-1.0	-1.9
Wears glasses or contact lenses	1.2	1.4	2.3	1.5	0.9	1.0
Arm fat-free mass (left)	1.2	6.3	17.3	-1.1	-0.6	-4.2
Vascular/heart problems diagnosed by doctor	1.2	3.3	6.8	0.6	1.7	2.6
Arm predicted mass (left)	1.2	6.1	16.5	-1.0	-0.9	-4.1
Intelligence (Savage-Jansen 2018)	1.1	3.4	9.6	-0.8	-3.1	-0.3
Hair/balding pattern: Pattern 3	1.1	1.6	4.0	0.9	2.0	0.1
Prospective memory result	1.1	1.4	2.2	-1.1	1.5	-0.8
Number of full brothers	1.1	1.4	2.4	-0.8	1.0	-1.6
Angina (self-reported)	1.1	1.4	3.3	-0.6	-0.7	-1.8
Osteoarthritis (self-reported)	1.1	1.5	4.1	0.5	2.0	-0.2
Verbal and Numeric Reasoning (VNR)	1.0	2.3	5.1	-0.0	-2.3	-1.3
Breast Cancer	1.0	2.5	7.1	0.3	2.7	-0.5
Ulcerative Colitis	1.0	1.5	2.7	0.5	1.2	1.7
Systolic Blood Pressure	1.0	5.0	9.3	-2.4	0.3	-3.0
Supplements: Zinc	1.0	1.1	3.0	-1.7	-0.4	-0.3
Trunk fat percentage	1.0	3.9	7.8	-1.8	-0.8	-2.8
Length of working week for main job	1.0	1.1	1.8	-1.1	-0.4	-1.3
Tense / ‘highly strung’	1.0	1.6	2.2	-1.4	-1.5	-0.7
Neck or shoulder pain in last month	1.0	1.4	2.4	1.5	0.2	1.4
Heart disease (mother)	1.0	1.2	2.8	1.7	-0.1	-0.9
Number of full sisters	1.0	1.2	2.4	-0.7	-1.6	-0.7
Suffer from ‘nerves’	1.0	1.6	2.7	-1.7	-0.2	-1.4
Hypertension (Self-reported)	1.0	2.8	4.9	-0.5	-1.8	-2.2
Crohns Disease (2017)	0.9	2.0	2.5	-1.1	-1.5	-1.6
Average weekly spirits intake	0.9	1.2	3.2	1.8	-0.4	0.3
High blood pressure	0.9	2.4	4.0	-0.3	-1.8	-2.0
Illnesses of siblings	0.9	1.3	3.8	0.2	0.2	1.9
Hip circumference	0.9	4.1	11.0	-0.9	-0.7	-3.3
Pulse rate	0.9	1.5	2.8	-1.0	-0.8	1.7
Lung cancer (father)	0.9	1.1	2.1	0.5	-0.9	1.4
Impedance of arm (left)	0.9	3.9	11.2	0.6	-0.4	3.4
Glaucoma (self-reported)	0.9	1.1	2.2	0.7	0.8	1.5
High blood pressure (siblings)	0.9	1.3	3.7	0.3	-0.3	-1.9
Shortness of breath walking on level ground	0.9	1.0	2.7	-0.3	0.5	-1.6
Supplements: Vitamin C	0.9	1.0	1.2	0.9	1.0	1.1
Breast cancer (self-reported)	0.9	1.0	3.0	0.3	0.1	1.7
Schizophrenia vs Biploar Disorder	0.8	1.1	1.2	1.1	-1.1	1.0
Ovarian Cancer	0.8	1.0	2.5	-1.6	-0.3	-0.7
Chronic bronchitis/emphysema (father)	0.8	1.0	2.2	-0.9	-1.5	-0.1
Impedance of arm (right)	0.8	3.9	10.7	1.0	-0.0	3.3
Peak expiratory flow (PEF)	0.8	1.9	5.5	-2.4	-0.3	0.5
Body fat percentage	0.8	3.0	6.7	-1.5	-0.3	-2.6
Pulse rate, automated reading	0.8	2.6	3.8	1.6	-1.2	2.0
Chest pain or discomfort	0.8	1.1	1.9	1.4	-1.2	-0.2
Average weekly beer plus cider intake	0.8	1.1	3.2	-0.3	-0.2	-1.8
Bipolar Disorder (2018)	0.7	1.1	2.0	-1.4	-0.0	-1.2
Major Depression (MDD)	0.7	0.8	2.0	1.4	-0.6	0.2
Cardiovascular Disease	0.7	2.3	4.2	-1.1	-1.3	-2.0
Townsend deprivation index at recruitment	0.7	1.0	2.6	-1.6	-0.4	-0.3
Multivitamins +/- minerals	0.7	0.9	2.2	1.5	0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.8	0.1	0.1	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.4	0.1	-1.0	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.2	2.0	-1.4	-0.8	1.0
Migraine (self-reported)	0.7	0.9	2.1	0.3	0.7	1.4
Medication: Ibuprofen	0.7	0.8	1.9	1.4	0.1	0.6
Family relationship satisfaction	0.7	0.8	1.2	-1.1	-0.5	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.3	-0.0	1.5	0.3
Illnesses of father: Heart disease	0.7	1.0	1.8	0.5	-1.4	-0.9
High cholesterol (Self-reported)	0.7	1.2	3.0	-0.8	-1.7	-0.0
Illnesses of father: High blood pressure	0.7	0.8	1.7	-0.0	-0.9	-1.3
Number of operations (self-reported)	0.7	1.0	2.6	1.6	-0.6	0.3
Risk taking	0.7	1.0	1.9	0.4	0.9	-1.4
Myopia	0.7	1.0	1.9	-0.6	-1.4	-0.8
Supplements: Calcium	0.7	0.7	1.3	1.1	-0.7	0.7
Worry (Nagel 2018)	0.6	1.3	2.3	-1.5	-1.2	0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	-0.7	-1.0	-0.6
Neuroticism (2016)	0.6	0.8	2.1	-0.1	1.4	-0.6
Schizophrenia (2014)	0.6	1.2	2.5	1.6	1.1	0.1
Hypothyroidism (self reported)	0.6	1.4	2.4	1.6	1.3	0.2
Pack years adult smoking proportion	0.6	0.9	1.5	-0.4	1.2	-1.1
Age when periods started (menarche)	0.6	1.4	2.3	1.4	-0.2	1.5
Alcohol usually taken with meals	0.6	1.0	1.9	0.1	-1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.7	-0.7	0.9	-1.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.7	0.5	-0.5	-1.3
Allergy	0.6	1.3	1.5	-1.0	-1.2	-1.2
Number of live births	0.6	0.8	2.2	0.5	-0.3	1.5
Happiness	0.6	0.7	1.0	-0.6	0.8	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.6	-0.7	0.8	2.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-0.5	-0.5	-1.3
Forced vital capacity (FVC), Best measure	0.6	2.1	3.5	-1.2	1.1	1.9
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-1.2	-0.8	0.6
Eye problems/disorders: None of the above	0.6	0.7	1.2	0.8	1.1	-0.4
Comparative height size at age 10	0.6	3.1	5.7	-0.8	-1.8	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	0.9	0.0	1.1
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	-0.9	-1.4	0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	1.4	0.3	0.3
Fractured/broken bones in last 5 years	0.6	0.7	1.2	-1.1	-1.0	-0.1
Cholesterol lowering medication	0.6	0.8	2.3	0.4	-1.5	0.1
Heart disease (siblings)	0.6	0.8	2.1	0.5	0.1	-1.4
Pack years of smoking	0.6	0.9	1.6	-0.4	1.0	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.2	1.4	1.2	1.0	-1.1
Heel T-Score	0.5	3.9	11.2	-0.0	0.7	-3.3
Sensitivity / hurt feelings	0.5	0.8	2.0	-0.1	0.7	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.5	0.4	-0.6	1.2
Vitamin and mineral supplements	0.5	0.7	1.1	-1.1	-0.9	-0.5
Medication: Co-codamol	0.5	0.6	1.2	0.7	-0.3	1.1
Diabetes (mother)	0.5	0.6	1.3	1.1	-0.7	-0.1
Fed-up feelings	0.5	0.9	2.4	0.6	1.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-1.3	-0.2	-0.1
Medication: Atenolol	0.5	0.7	1.3	1.1	0.5	-0.7
High blood pressure (mother)	0.5	0.6	1.6	1.3	-0.6	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	0.7	0.2	-1.7
Financial difficulties in last 2 years	0.5	0.7	1.2	0.2	-0.9	-1.1
Medication: Simvastatin	0.5	0.8	1.0	-1.0	-0.7	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.3	1.1	1.0	0.5
Exposure to tobacco smoke at home	0.5	0.5	1.5	-0.1	-1.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	0.5	1.4	-0.4
Headache pain in last month	0.5	0.8	1.3	1.1	0.8	0.8
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.3	0.6	1.1	-1.1
Wheeze or whistling in the chest in last year	0.5	0.8	1.3	1.1	-0.5	1.0
Age at first live birth	0.5	0.8	1.0	-0.9	0.8	-1.0
Health satisfaction	0.5	0.6	0.9	-0.8	-0.6	-1.0
Age at last live birth	0.5	0.8	2.3	-1.5	0.0	0.1
Average weekly red wine intake	0.5	0.8	1.5	0.9	-0.0	1.2
Long-standing illness, disability or infirmity	0.5	0.7	1.9	0.2	-1.4	-0.4
Qualifications: nursing, teaching	0.5	0.8	1.3	-1.1	0.6	-0.9
Mineral and other dietary supplements	0.5	0.7	1.2	-1.1	-0.3	-0.9
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	-0.4	1.3	-0.0
Commuting to job workplace: Public transport	0.5	0.6	1.0	1.0	-0.1	-0.9
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	1.1	0.8	0.2
Medication: Lisinopril	0.5	0.7	1.2	-0.5	-1.1	-0.8
Medication: Atorvastatin	0.5	0.6	1.2	-0.8	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.4	0.9	1.3	1.2	1.1	-0.4
HbA1C	0.4	0.5	0.7	-0.8	-0.6	0.6
HDL Cholesterol	0.4	0.6	1.1	-0.1	-0.9	1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.5	-0.4	-0.7	-1.2
Chronotype (morning person)	0.4	1.0	1.6	1.3	-0.3	1.2
Medication for hormone replacement therapy	0.4	0.4	0.6	0.7	-0.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.2	0.6	0.3	-1.5
Qualifications: CSEs or equivalent	0.4	0.6	1.1	0.8	0.1	1.1
Noisy workplace	0.4	0.5	1.5	1.2	-0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.6	-0.1	1.3	-1.0
Breastfed as a baby	0.4	0.4	1.0	0.5	-1.0	-0.1
Gout (self-reported)	0.4	0.5	1.0	0.0	-0.8	1.0
Worry too long after embarrassment	0.4	0.7	1.2	0.8	1.1	-0.4
Alcohol intake frequency.	0.4	0.9	1.3	1.1	-1.1	-0.4
Leg pain on walking	0.4	0.5	1.4	0.2	-1.2	-0.2
Illnesses of siblings: Diabetes	0.4	0.5	1.0	0.6	-1.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.0	-0.8	-0.9	-1.0
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.0	-0.9	0.7
Average weekly champagne plus white wine intake	0.4	0.6	1.5	-1.2	0.5	-0.2
Mother’s age at death	0.4	0.5	1.3	0.4	-1.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-1.0	-0.1	-0.5
Medication: Bendroflumethiazide	0.4	0.5	1.3	-1.2	-0.3	-0.5
Leg fat percentage (left)	0.4	1.4	2.9	-1.1	0.1	-1.7
Age started oral contraceptive pill	0.4	0.5	1.1	1.1	-0.5	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-1.2	-0.7	-0.1
Ulcerative Colitis (UC)	0.3	0.6	0.9	-1.0	-0.3	0.9
Bipolar Disorder (2011)	0.3	0.3	0.7	0.3	0.8	0.3
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.1	0.8	-0.8
Rheumatoid Arthritis	0.3	0.4	1.1	0.2	-0.4	1.0
Height	0.3	6.5	10.7	-0.8	-2.9	-3.3
Smoking Status	0.3	0.7	1.8	0.1	0.5	1.4
Respiratory disease	0.3	0.7	2.1	1.4	-0.1	-0.1
Number of treatments/medications taken	0.3	0.5	0.7	-0.5	-0.8	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	1.1	0.3	-0.0
Hearing difficulty/problems: Yes	0.3	0.5	0.8	-0.9	-0.6	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.6	-0.3	0.7
Current tobacco smoking	0.3	0.5	1.4	-0.2	0.1	1.2
Relative age voice broke	0.3	0.5	1.1	0.2	0.5	1.0
Past tobacco smoking	0.3	0.5	0.7	0.7	-0.6	0.8
Forced vital capacity (FVC)	0.3	1.1	1.9	-0.6	1.4	1.0
Qualifications: None of the above	0.3	0.7	1.1	-1.1	-1.0	-0.3
Mouth/teeth dental problems	0.3	0.5	0.9	-0.2	-1.0	0.6
Pain all over the body in last month	0.3	0.3	0.7	0.5	0.3	0.8
Worrier / anxious feelings	0.3	0.5	1.2	-0.2	-1.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.5	-0.7	1.0	1.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.5	0.9	-0.6
Medication: Lansoprazole	0.3	0.3	0.9	-0.1	0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.7	-0.6	-0.6	-0.8
Hair/balding pattern: Pattern 4	0.3	0.7	1.1	-0.9	-1.1	-0.5
Medication: Paracetamol	0.3	0.5	1.5	1.2	0.3	0.0
Number of children fathered	0.3	0.4	0.9	0.2	0.9	0.4
Smoking status: Previous	0.3	0.4	0.5	-0.6	0.5	-0.7
Loneliness, isolation	0.3	0.4	1.0	-0.0	1.0	-0.1
Commuting to job workplace: Walk	0.3	0.4	1.0	1.0	-0.4	-0.0
Medication for cholesterol	0.3	0.5	1.0	-0.1	0.8	1.0
Smoking status: Current	0.3	0.5	1.2	-0.4	0.1	1.1
Medication: Paracetamol	0.3	0.5	1.3	1.1	-0.5	0.1
Irritability	0.3	0.6	1.1	-1.1	0.3	0.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.5	0.3	0.6	-0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.7	-0.2	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	-0.1	-0.9	0.3
Age at First Birth	0.2	0.3	0.7	-0.1	0.5	-0.9
Coronary Artery Disease (CAD)	0.2	0.2	0.7	0.1	0.8	-0.1
LDL Cholesterol	0.2	0.4	1.1	0.2	0.0	1.1
Lupus	0.2	0.3	0.9	-0.2	-0.9	0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	0.7	0.5	0.3
Blood White Count	0.2	1.1	2.9	-0.6	-1.7	-0.3
Diabetes (father)	0.2	0.3	0.5	0.7	0.2	-0.6
Taking other prescription medications	0.2	0.3	0.9	-0.1	-0.9	0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	0.9	0.7	0.6
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.5	0.6	0.4
Supplements: Glucosamine	0.2	0.3	0.8	-0.4	0.9	0.1
Medication: Levothyroxine sodium	0.2	0.4	1.0	-0.2	1.0	-0.5
Number of incorrect matches in round	0.2	0.3	0.5	0.5	0.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	-0.2	-0.9	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.8	-0.1	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.0	-0.5	0.6
Standing height	0.2	2.2	4.4	-0.5	-2.1	-1.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.2	0.8	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	0.8	0.1	0.0
Blood clot in the leg (DVT)	0.2	0.2	0.5	0.3	0.4	-0.7
Birth weight	0.2	0.3	0.8	-0.3	0.4	-0.9
Leg fat percentage (right)	0.2	0.6	1.6	-0.5	0.2	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.4	-0.2	-0.7	-0.5
Pulse wave peak to peak time	0.2	0.2	0.5	-0.1	0.5	-0.7
Qualifications: College or University degree	0.2	0.6	1.1	-1.1	-0.3	-0.8
Medication: Allopurinol	0.2	0.3	0.7	-0.2	-0.8	0.5
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.5	-0.6	0.2
Overall health rating	0.2	0.4	0.7	-0.5	-0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	-0.8	0.2	-0.3
Ever had bowel cancer screening	0.2	0.2	0.4	0.2	-0.5	0.6
Miserableness	0.2	0.3	0.5	0.7	0.1	-0.5
Guilty feelings	0.2	0.4	1.0	1.0	-0.0	-0.3
Financial situation satisfaction	0.2	0.3	0.4	-0.6	-0.6	0.1
Medication: Blood pressure	0.2	0.5	0.9	-0.3	-0.7	-0.9
Ever smoked	0.2	0.4	0.7	-0.7	0.8	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.4	0.4	-0.5
Diastolic blood pressure, automated reading	0.2	0.5	0.7	0.4	-0.8	-0.8
Ever depressed for a whole week	0.2	0.2	0.6	-0.2	-0.1	0.8
Crohns Disease (2012)	0.1	0.2	0.3	-0.5	-0.5	-0.5
Triglycerides	0.1	0.2	0.4	-0.6	0.2	-0.4
Blood Platelet Count	0.1	1.0	2.6	0.3	-0.6	1.6
Allergy or Eczema	0.1	0.2	0.4	-0.6	0.4	0.1
Lung FEV1/FVC ratio	0.1	0.6	1.1	1.1	-0.2	0.8
Neuroticism	0.1	0.3	0.6	-0.8	0.2	-0.4
Hand grip strength (left)	0.1	0.1	0.3	0.0	0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.3	0.3	-0.1
Severe depression (siblings)	0.1	0.1	0.1	0.3	-0.3	0.1
Hand grip strength (right)	0.1	0.1	0.4	-0.6	-0.0	-0.2
Average weekly fortified wine intake	0.1	0.1	0.2	0.4	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.4	-0.7	0.2	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.0	-0.6	-0.2
Sitting height	0.1	0.6	1.2	-1.1	-0.2	-0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.2	-0.5	-0.5	-0.3
Neuroticism score	0.1	0.2	0.6	-0.8	0.1	-0.1
Asthma	0.1	0.1	0.3	0.6	0.1	-0.2
Birth weight of first child	0.1	0.2	0.3	0.6	-0.2	-0.4
Pulse wave reflection index	0.1	0.1	0.2	0.4	0.3	0.3
Loud music exposure frequency	0.1	0.1	0.1	-0.4	0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.5	-0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	-0.1	0.5	-0.5
Knee pain experienced in last month	0.1	0.1	0.3	0.0	-0.2	-0.6
Mood swings	0.1	0.2	0.4	0.6	0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	-0.7	0.1	-0.2
Back pain experienced in last month	0.1	0.2	0.3	-0.3	-0.6	0.2
Unable to work because of sickness or disability	0.1	0.1	0.4	-0.0	-0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.1	-0.4	0.0
Pain experienced in last month	0.1	0.1	0.2	-0.4	0.1	-0.4
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	-0.3	-0.6	0.0
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	-0.5	0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.1	-0.0	0.2	0.3
Mean Putamen Volume	0.0	0.0	0.1	0.1	0.2	0.2
Blood Eosinophil Count	0.0	0.4	0.6	0.5	-0.5	-0.8
Blood Red Count	0.0	0.1	0.3	0.1	0.5	0.0
Hair Pigment	0.0	1.1	3.2	1.8	-0.2	-0.3
Tanning	0.0	0.0	0.0	-0.1	-0.0	-0.1
Medication: Omeprazole	0.0	0.0	0.1	-0.2	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.2	-0.1	-0.1
Asthma (self-reported)	0.0	0.1	0.1	0.3	0.1	-0.3
Hearing aid user	0.0	0.0	0.0	0.0	-0.2	-0.0

Hub : Genes

KIAA0087

Models

Trait associations