Best TWAS P=1.24e-10 · Best GWAS P=3.65e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PHF11 | 0.05 | 0.02 | bslmm | 404 | 0.02 | 6.7e-04 | -3.8 | -5.4 | 6.6e-08 | 0.69 | 0.11 | 0.79 | FALSE |
| 2 | GTEx | Adrenal Gland | CDADC1 | 0.27 | 0.20 | lasso | 5 | 0.18 | 4.7e-07 | 5.7 | 6.1 | 1.1e-09 | -0.07 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Colon Transverse | SETDB2 | 0.15 | 0.02 | lasso | 7 | 0.05 | 3.0e-03 | 4.3 | -5.1 | 2.9e-07 | 0.75 | 0.08 | 0.76 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | EBPL | 0.27 | 0.24 | enet | 14 | 0.26 | 4.6e-10 | 4.7 | -5.1 | 2.8e-07 | 0.04 | 0.38 | 0.62 | FALSE |
| 5 | GTEx | Pituitary | EBPL | 0.44 | 0.32 | enet | 29 | 0.37 | 3.1e-10 | 4.7 | -6.4 | 1.2e-10 | 0.28 | 0.20 | 0.78 | TRUE |
| 6 | GTEx | Pituitary | SETDB2 | 0.26 | 0.13 | enet | 12 | 0.20 | 7.4e-06 | 4.1 | -5.5 | 4.5e-08 | 0.74 | 0.02 | 0.91 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | EBPL | 0.34 | 0.26 | enet | 12 | 0.30 | 4.0e-17 | 4.7 | -5.3 | 1.3e-07 | 0.08 | 0.32 | 0.68 | FALSE |
| 8 | GTEx | Testis | EBPL | 0.33 | 0.17 | lasso | 6 | 0.24 | 8.4e-11 | 4.6 | -5.7 | 1.0e-08 | 0.11 | 0.12 | 0.88 | FALSE |
| 9 | METSIM | Adipose | SETDB2 | 0.06 | 0.03 | enet | 17 | 0.05 | 5.1e-08 | -2.8 | -5.3 | 1.2e-07 | 0.68 | 0.67 | 0.31 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAB39L | 0.03 | 0.00 | blup | 89 | 0.01 | 2.2e-02 | -3.6 | -5.3 | 1.3e-07 | 0.47 | 0.02 | 0.18 | FALSE |
| 11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CAB39L | 0.12 | 0.12 | lasso | 3 | 0.11 | 2.3e-05 | -5.9 | -5.9 | 3.9e-09 | 1.00 | 0.00 | 0.99 | TRUE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | CAB39L | 0.15 | 0.07 | blup | 89 | 0.08 | 3.9e-08 | -4.1 | -5.5 | 4.9e-08 | 0.78 | 0.01 | 0.99 | FALSE |