[Hub]/) : Traits : Lung FVC : ← →

chr16:27,655,848-29,595,483

Best TWAS P=1.16e-11 · Best GWAS P=3.38e-11 conditioned to 0.0797

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	EIF3C	0.12	0.04	enet	12	0.07	1.4e-06	6.6	-5.6	2.2e-08	-0.77	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	EIF3CL	0.11	0.08	enet	9	0.14	7.8e-12	-4.4	-6.4	1.8e-10	-0.78	0.01	0.99	FALSE
3	GTEx	Artery Aorta	SULT1A1	0.06	0.05	lasso	1	0.01	7.3e-02	-5.4	5.3	8.6e-08	0.53	0.07	0.16	FALSE
4	GTEx	Artery Coronary	SH2B1	0.10	0.09	lasso	6	0.03	4.5e-02	-5.4	6.0	1.6e-09	0.63	0.03	0.48	FALSE
5	GTEx	Artery Coronary	RP11-1348G14.4	0.12	0.11	lasso	2	0.09	7.6e-04	-5.4	5.7	1.5e-08	0.56	0.27	0.30	FALSE
6	GTEx	Artery Tibial	EIF3C	0.07	0.07	lasso	5	0.07	2.6e-06	-4.5	-5.9	2.9e-09	-0.66	0.10	0.90	FALSE
7	GTEx	Artery Tibial	EIF3CL	0.05	0.03	lasso	2	0.04	8.3e-04	-3.9	-5.7	1.2e-08	-0.68	0.04	0.94	FALSE
8	GTEx	Brain Cortex	LAT	0.17	0.04	lasso	4	0.04	2.2e-02	-3.8	-6.0	2.6e-09	-0.67	0.10	0.33	FALSE
9	GTEx	Breast Mammary Tissue	NFATC2IP	0.10	0.02	lasso	5	0.04	4.6e-03	-3.7	-5.5	3.3e-08	-0.62	0.26	0.50	FALSE
10	GTEx	Cells Transformed fibroblasts	SULT1A1	0.05	0.05	enet	9	0.04	4.5e-04	-4.1	5.6	2.0e-08	0.62	0.18	0.79	FALSE
11	GTEx	Colon Transverse	NFATC2IP	0.07	0.08	lasso	6	0.09	3.5e-05	-4.6	-6.0	1.5e-09	-0.70	0.21	0.70	FALSE
12	GTEx	Esophagus Muscularis	CCDC101	0.07	0.07	enet	5	0.04	2.2e-03	-5.4	5.9	3.9e-09	0.65	0.04	0.81	FALSE
13	GTEx	Esophagus Muscularis	SH2B1	0.06	0.03	enet	21	0.06	1.9e-04	-4.5	5.2	1.6e-07	0.59	0.19	0.74	FALSE
14	GTEx	Esophagus Muscularis	SULT1A1	0.10	0.09	enet	16	0.08	1.0e-05	-5.4	5.2	2.6e-07	0.54	0.79	0.19	FALSE
15	GTEx	Heart Atrial Appendage	SULT1A1	0.14	0.08	enet	13	0.09	5.5e-05	-5.4	5.5	3.1e-08	0.55	0.33	0.58	FALSE
16	GTEx	Heart Left Ventricle	EIF3C	0.09	0.10	lasso	5	0.07	1.0e-04	5.8	-5.6	2.4e-08	-0.79	0.01	0.96	FALSE
17	GTEx	Heart Left Ventricle	SULT1A1	0.16	0.11	lasso	4	0.09	1.2e-05	-5.4	5.3	9.2e-08	0.54	0.19	0.65	FALSE
18	GTEx	Lung	EIF3C	0.04	0.02	lasso	4	0.02	1.1e-02	-4.4	-6.3	3.2e-10	-0.78	0.02	0.91	FALSE
19	GTEx	Lung	SULT1A1	0.07	0.09	lasso	3	0.07	8.6e-06	-5.4	5.2	1.9e-07	0.50	0.76	0.23	FALSE
20	GTEx	Nerve Tibial	EIF3C	0.15	0.05	lasso	6	0.08	1.8e-06	-3.8	-6.2	4.8e-10	-0.78	0.01	0.99	FALSE
21	GTEx	Nerve Tibial	SULT1A1	0.17	0.09	enet	21	0.08	2.7e-06	-3.8	5.3	9.6e-08	0.50	0.80	0.19	FALSE
22	GTEx	Ovary	RP11-22P6.2	0.10	0.02	enet	24	0.06	1.3e-02	-4.1	6.0	1.6e-09	0.66	0.10	0.38	FALSE
23	GTEx	Skin Sun Exposed Lower leg	EIF3C	0.07	0.06	lasso	4	0.07	4.1e-06	-4.5	-5.4	5.4e-08	-0.55	0.33	0.67	FALSE
24	GTEx	Stomach	EIF3C	0.11	0.07	enet	12	0.06	8.6e-04	-4.5	-6.5	9.9e-11	-0.68	0.08	0.83	FALSE
25	GTEx	Stomach	EIF3CL	0.09	0.06	lasso	3	0.12	2.5e-06	5.8	-5.7	1.1e-08	-0.66	0.16	0.76	FALSE
26	GTEx	Testis	EIF3C	0.09	0.05	lasso	4	0.08	2.3e-04	6.6	-6.8	1.2e-11	-0.83	0.01	0.98	TRUE
27	GTEx	Whole Blood	EIF3C	0.06	0.01	lasso	4	0.01	1.9e-02	-4.1	-5.3	1.5e-07	-0.59	0.04	0.77	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	NUPR1	0.05	0.04	bslmm	200	0.02	3.1e-04	-5.4	-5.2	2.1e-07	-0.45	0.70	0.19	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	EIF3C	0.12	0.16	enet	20	0.15	4.0e-19	-4.4	-5.3	1.5e-07	-0.62	1.00	0.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	NPIPB6	0.14	0.12	bslmm	259	0.11	1.2e-13	6.6	-6.8	1.2e-11	-0.96	0.00	1.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	RP11-1348G14.1	0.03	0.01	blup	175	0.02	3.6e-03	5.9	6.8	1.3e-11	0.72	0.02	0.95	FALSE
32	YFS	Blood	CCDC101	0.18	0.28	lasso	2	0.28	1.4e-93	-5.4	5.3	8.6e-08	0.53	0.66	0.34	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF3C	0.07	0.03	lasso	3	0.07	1.1e-06	-4.6	-6.2	7.5e-10	-0.76	0.04	0.95	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF3CL	0.08	0.13	blup	18	0.14	4.3e-28	-4.5	-5.3	1.5e-07	-0.65	0.99	0.01	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF3CL	0.10	0.02	blup	18	0.08	7.7e-05	-4.7	-5.8	7.1e-09	-0.70	0.01	0.97	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF3C	0.09	0.03	blup	10	0.03	8.6e-03	6.6	-6.6	5.3e-11	-0.84	0.00	0.96	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF3CL	0.21	0.10	lasso	3	0.11	8.9e-07	-4.6	-5.9	4.0e-09	-0.76	0.05	0.94	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	EIF3CL	0.20	0.24	lasso	6	0.31	3.9e-10	-4.5	-5.8	6.5e-09	-0.72	0.14	0.86	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EIF3CL	0.12	0.06	blup	18	0.08	2.4e-09	-4.5	-5.6	2.6e-08	-0.69	0.13	0.86	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF3CL	0.08	0.07	lasso	3	0.07	9.4e-05	-4.5	-5.6	2.3e-08	-0.67	0.04	0.85	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	NUPR1	0.03	0.03	lasso	4	0.04	4.8e-05	-5.4	-5.1	2.9e-07	-0.52	0.00	0.99	FALSE
42	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EIF3C	0.05	0.02	blup	10	0.03	1.5e-02	-4.6	-5.6	2.7e-08	-0.63	0.01	0.49	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF3C	0.01	0.02	blup	10	0.01	1.3e-02	-4.6	-5.2	2.5e-07	-0.56	0.02	0.14	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF3CL	0.06	0.09	blup	18	0.09	1.5e-10	-4.6	-5.8	6.2e-09	-0.66	0.88	0.12	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SULT1A1	0.03	0.03	lasso	2	0.02	1.3e-03	-5.4	5.4	6.1e-08	0.53	0.00	0.94	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SULT1A1	0.07	0.07	enet	3	0.04	9.2e-04	-5.4	5.4	5.5e-08	0.54	0.00	0.98	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EIF3CL	0.20	0.12	lasso	3	0.18	1.2e-07	-3.7	-5.6	2.5e-08	-0.69	0.04	0.94	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC101	0.06	0.08	lasso	4	0.07	6.4e-08	-5.4	5.2	1.5e-07	0.53	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	SULT1A1	0.11	0.07	lasso	2	0.06	9.7e-07	-5.4	5.4	7.5e-08	0.53	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	SULT1A1	0.06	0.04	blup	26	0.04	1.6e-03	-5.4	5.3	1.3e-07	0.52	0.00	0.84	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	EIF3C	0.03	0.04	lasso	2	0.04	5.7e-05	-4.7	-5.2	2.5e-07	-0.55	0.21	0.29	FALSE