TWAS hub - NPIPB6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0528	0.0187	4.1e-07	0.045	0.047	0.040	0.046	0.044	2.1e-07	1.3e-07	9.6e-07	1.9e-07	3.0e-07
2	ROSMAP	Brain Pre-frontal Cortex	0.1434	0.0410	1.3e-08	0.118	0.060	0.097	0.107	0.096	7.0e-15	3.6e-08	1.9e-12	1.2e-13	2.2e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Arm fat percentage (left)	30.0	119.6	156.2	12.5	9.1
Arm fat percentage (right)	29.5	116.3	153.8	12.4	8.9
Trunk fat percentage	29.3	117.4	148.8	12.2	9.3
Intelligence (Savage-Jansen 2018)	28.8	88.4	90.6	-9.3	-9.5
Trunk fat mass	28.8	123.9	161.3	12.7	9.3
Waist circumference	28.8	105.5	132.2	11.5	8.9
Arm fat mass (right)	28.3	116.5	153.8	12.4	8.9
Hip circumference	28.1	121.2	156.2	12.5	9.3
Whole body fat mass	27.8	116.1	151.3	12.3	9.0
Arm fat mass (left)	27.8	114.3	151.3	12.3	8.8
Alcohol intake frequency.	27.1	63.0	94.0	9.7	5.7
Body fat percentage	26.3	104.0	132.2	11.5	8.7
BMI	22.6	130.8	166.4	12.9	9.8
Body Mass Index (BMI) (2010)	22.3	30.6	35.1	5.9	5.1
Leg fat mass (left)	22.0	85.7	112.4	10.6	7.7
Weight	21.4	105.4	144.0	12.0	8.2
Leg fat mass (right)	21.2	82.4	108.2	10.4	7.5
Irritable Bowel Disease (IBD)	19.8	47.0	54.8	7.4	6.3
Body mass index (BMI)	19.6	83.5	108.6	10.4	7.6
Verbal and Numeric Reasoning (VNR)	19.5	46.9	48.5	-7.0	-6.7
Crohns Disease (2017)	17.3	38.1	46.4	6.8	5.5
Fluid intelligence score	17.3	35.8	37.2	-6.1	-5.9
Crohns Disease (2012)	16.8	27.0	36.9	6.1	4.1
Leg fat percentage (left)	15.4	55.7	66.1	8.1	6.7
Leg predicted mass (left)	14.9	78.9	110.2	10.5	6.9
Leg fat-free mass (left)	14.8	78.4	110.2	10.5	6.8
Comparative body size at age 10	14.6	40.2	60.8	7.8	4.4
Leg fat percentage (right)	13.8	49.8	60.3	7.8	6.3
Leg predicted mass (right)	13.7	73.1	104.0	10.2	6.5
Leg fat-free mass (right)	13.5	72.3	102.0	10.1	6.5
Qualifications: College or University degree	11.7	37.0	47.3	-6.9	-5.2
Suffer from ‘nerves’	11.5	18.0	24.0	4.9	3.5
Ulcerative Colitis (UC)	10.9	20.5	22.2	4.3	4.7
Qualifications: None of the above	10.9	23.4	31.2	5.6	3.9
Basal metabolic rate	10.5	57.9	81.9	9.1	5.8
Pack years adult smoking proportion	10.3	15.8	18.9	3.6	4.3
Handedness (chirality/laterality): Left-handed	8.2	9.8	11.4	3.4	2.9
Pack years of smoking	7.3	10.7	12.4	3.0	3.5
Eye problems/disorders: None of the above	7.2	8.4	11.1	3.3	2.4
Whole body fat-free mass	7.1	40.5	58.7	7.7	4.7
Allergy or Eczema	6.9	18.3	29.8	-5.5	-2.6
Hand grip strength (right)	6.9	18.7	20.5	-4.5	-4.1
Whole body water mass	6.8	38.9	56.7	7.5	4.6
Lung FVC	6.5	33.0	46.1	-4.5	-6.8
Serious illness, injury or assault of a close relative in last 2 years	6.5	7.5	8.5	-2.9	-2.6
Blood Red Count	6.4	61.6	79.2	-8.9	-6.6
Pulse wave peak to peak time	6.4	7.6	9.8	3.1	2.3
Qualifications: CSEs or equivalent	6.3	8.3	10.0	2.6	3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.3	13.4	13.8	-3.6	-3.7
Rheumatoid Arthritis	6.2	8.5	8.5	2.9	2.9
Ulcerative Colitis	6.1	8.9	9.3	3.0	2.9
Birth weight of first child	6.0	11.0	16.2	4.0	2.4
Comparative height size at age 10	6.0	32.8	47.5	6.9	4.2
Arm fat-free mass (left)	6.0	30.5	42.6	6.5	4.3
Breastfed as a baby	5.9	7.3	7.8	-2.6	-2.8
Arm predicted mass (left)	5.9	29.8	41.6	6.5	4.2
Qualifications: A levels/AS levels or equivalent	5.7	12.6	14.9	-3.9	-3.2
Smoking status: Previous	5.7	8.5	12.8	-2.0	-3.6
Alcohol drinker status: Never	5.7	6.8	10.3	3.2	1.8
Average weekly red wine intake	5.6	8.3	9.7	-3.1	-2.6
Impedance of leg (right)	5.4	26.2	40.1	-6.3	-3.5
Medication: Paracetamol	5.2	8.1	11.1	3.3	2.2
Impedance of leg (left)	5.0	24.4	37.9	-6.2	-3.3
Arm fat-free mass (right)	5.0	25.9	37.2	6.1	3.8
Arm predicted mass (right)	5.0	25.5	37.1	6.1	3.7
Alcohol usually taken with meals	4.8	7.8	8.9	-2.6	-3.0
Pulse wave Arterial Stiffness index	4.8	5.6	6.7	-2.6	-2.1
Mean Putamen Volume	4.7	5.4	10.6	-3.3	0.4
HDL Cholesterol	4.6	7.7	11.4	-2.0	-3.4
Hayfever, allergic rhinitis or eczema	4.5	9.9	16.2	-4.0	-1.9
Bipolar Disorder (2018)	4.4	7.0	9.1	3.0	2.2
Fed-up feelings	4.3	7.9	8.7	2.7	2.9
HbA1C	4.2	4.7	6.0	2.5	1.8
Medication: Co-codamol	4.2	4.8	6.4	2.5	1.8
Number of live births	4.2	5.9	11.0	-3.3	-0.9
Bipolar Disorder (2011)	4.1	4.0	6.0	2.5	1.4
Past tobacco smoking	4.1	7.4	10.3	2.1	3.2
Supplements: Calcium	4.1	4.5	5.9	-2.4	-1.7
Eye problems/disorders: Cataract	4.0	4.6	5.5	-2.3	-1.9
Medication: Paracetamol	3.9	6.4	8.6	2.9	2.0
Ever smoked	3.9	6.9	7.0	-2.6	-2.6
Medication: Metformin	3.8	5.3	6.8	2.6	2.0
Alzheimer’s Disease (in mother)	3.6	4.2	7.3	-1.0	-2.7
Hair/balding pattern: Pattern 4	3.5	8.4	15.3	-3.9	-1.2
Mouth/teeth dental problems: Loose teeth	3.5	4.1	4.3	2.1	2.0
Risk taking	3.5	5.2	7.4	-1.7	-2.7
Average weekly champagne plus white wine intake	3.4	4.7	7.8	-2.8	-1.2
Blood Platelet Count	3.3	38.2	75.3	-1.1	8.7
Trunk fat-free mass	3.3	19.0	29.1	5.4	3.0
Trunk predicted mass	3.3	19.0	28.9	5.4	3.0
Multivitamins +/- minerals	3.2	4.1	4.1	-2.0	-2.0
High blood pressure (mother)	3.2	4.5	8.4	0.8	2.9
Happiness	3.1	3.8	4.3	-2.1	-1.8
Birth weight	3.1	6.8	10.7	3.3	1.7
Mouth/teeth dental problems: Mouth ulcers	3.1	4.9	7.6	-1.5	-2.8
Medication: Gliclazide	3.1	3.5	5.2	2.3	1.3
Hypothyroidism (self reported)	3.0	6.9	7.0	2.6	2.6
Age when periods started (menarche)	3.0	7.2	11.2	-3.3	-1.8
Friendships satisfaction	2.9	3.6	4.6	-2.2	-1.6
Alzheimer’s Disease (including proxy)	2.8	4.1	7.6	-0.8	-2.8
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	7.1	-2.7	-0.5
Type 2 Diabetes (T2D) (2018)	2.7	5.0	5.4	2.3	2.2
Pulse wave reflection index	2.7	3.4	3.9	-1.7	-2.0
Long-standing illness, disability or infirmity	2.6	4.0	4.2	2.0	2.0
Commuting to job workplace: Public transport	2.6	3.1	5.3	-2.3	-1.0
Medication: Atorvastatin	2.6	3.3	3.4	-1.9	-1.8
Current tobacco smoking	2.5	4.0	4.2	2.0	2.1
Tense / ‘highly strung’	2.5	4.1	7.7	-0.7	-2.8
Wheeze or whistling in the chest in last year	2.5	4.4	4.5	2.1	2.1
Family relationship satisfaction	2.5	3.1	4.7	-1.2	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	5.5	2.3	2.2
Ever had bowel cancer screening	2.5	2.9	3.9	-1.4	-2.0
Ever taken oral contraceptive pill	2.5	2.8	5.0	-2.2	-0.7
Neck or shoulder pain in last month	2.4	3.5	3.8	-2.0	-1.8
Mother’s age at death	2.4	2.9	4.7	-1.1	-2.2
Hand grip strength (left)	2.3	6.1	7.5	-2.2	-2.7
Overall health rating	2.3	5.0	6.7	2.6	1.8
Myopia	2.3	3.4	3.8	-1.9	-1.7
Cardiovascular Disease	2.2	7.3	11.4	3.4	1.8
Nervous feelings	2.2	4.2	4.7	1.9	2.2
Migraine (self-reported)	2.2	2.7	2.9	-1.6	-1.7
Pulse rate, automated reading	2.2	7.0	13.6	0.6	3.7
Depressed Affect (Nagel 2018)	2.1	4.4	4.8	2.2	2.0
Had other major operations	2.1	2.6	3.0	1.7	1.5
Osteoporosis (self-reported)	2.1	2.6	2.6	-1.6	-1.6
Miserableness	2.1	3.7	5.0	2.2	1.6
Ever depressed for a whole week	2.1	2.6	3.5	-1.9	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	4.4	2.1	0.5
Breast Cancer	1.9	4.5	4.9	-2.0	-2.2
Diabetes (self-reported)	1.9	2.9	2.9	1.7	1.7
Medication: Lansoprazole	1.9	2.1	4.3	2.1	0.0
Alcohol drinker status: Previous	1.9	2.1	3.5	1.9	0.9
Blood White Count	1.8	13.4	26.2	0.8	5.1
Allergy	1.8	4.1	6.8	2.6	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	2.1	-1.4	-1.4
Medication: Blood pressure	1.8	3.3	4.8	1.3	2.2
Mood swings	1.8	3.3	3.8	1.7	1.9
Qualifications: nursing, teaching	1.8	2.8	4.7	-2.2	-0.9
Smoking status: Current	1.8	2.8	2.9	1.7	1.7
Bipolar Disorder or Schizophrenia	1.7	4.1	5.4	2.3	1.7
Chronotype (morning person)	1.7	3.9	5.7	1.4	2.4
Ever had hysterectomy (womb removed)	1.7	1.9	2.0	-1.4	1.4
Loneliness, isolation	1.7	2.4	4.0	2.0	0.9
Alcohol intake versus 10 years previously	1.6	2.4	3.0	1.7	1.3
Number of full sisters	1.6	2.0	2.8	-1.7	-1.1
Average weekly beer plus cider intake	1.6	2.3	2.4	1.5	1.6
Basal cell carcinoma (self-reported)	1.6	1.9	2.5	-1.6	-1.1
Stomach or abdominal pain in last month	1.5	1.9	3.0	-0.8	-1.7
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	3.7	-1.9	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	7.0	-1.4	-2.6
Standing height	1.4	14.0	23.7	4.9	2.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	3.1	1.5	1.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.2	1.8	0.2
Diabetes diagnosed by doctor	1.4	2.3	3.5	1.1	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	1.7	-1.3	-1.2
Diastolic blood pressure, automated reading	1.4	4.3	5.4	1.8	2.3
Exposure to tobacco smoke at home	1.3	1.4	2.8	0.3	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.8	-0.6	-1.7
Commuting to job workplace: Walk	1.3	1.4	1.9	-0.9	1.4
Eye problems/disorders: Glaucoma	1.3	1.5	2.7	-1.7	0.5
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	6.9	-1.1	-2.6
Fasting Glucose	1.1	1.3	1.6	1.3	1.0
Medication: Levothyroxine sodium	1.1	1.8	3.3	0.7	1.8
Heart attack	1.1	1.3	2.5	1.6	0.4
Lung cancer (father)	1.1	1.2	2.0	1.4	0.7
Medication: Amlodipine	1.1	1.5	2.8	1.7	0.6
Number of children fathered	1.1	1.3	2.1	-1.5	-0.7
Emphysema/chronic bronchitis	1.1	1.2	2.4	1.6	0.2
Medication: Ibuprofen	1.1	1.3	2.2	-0.7	1.5
Medication: Aspirin	1.1	1.5	2.0	-1.4	-1.0
Major Depression (MDD)	1.0	1.2	1.3	-1.1	-1.1
Supplements: Zinc	1.0	1.1	1.9	-1.4	0.5
Gout (self-reported)	1.0	1.4	2.4	1.6	0.6
Schizophrenia (2014)	0.9	2.0	3.5	0.7	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.2	1.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.6	1.3	0.6
Hearing difficulty/problems with background noise	0.9	1.4	2.5	-1.6	-0.6
Medication: Ramipril	0.9	1.2	1.8	1.3	0.8
Medication: Simvastatin	0.9	1.3	2.0	0.8	1.4
Falls in the last year	0.9	1.2	1.9	-1.4	-0.7
Hair/balding pattern: Pattern 3	0.9	1.3	2.5	-0.1	-1.6
Pulse rate	0.9	1.6	2.7	-1.6	0.7
Prospective memory result	0.9	1.1	2.2	1.5	0.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.6	1.3	0.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.7	-0.6	-1.6
Age at last live birth	0.9	1.2	1.4	1.0	1.2
Supplements: Vitamin C	0.9	1.0	2.0	1.4	-0.1
Mineral and other dietary supplements	0.9	1.1	2.2	0.3	1.5
Irritability	0.9	1.6	3.2	-0.1	-1.8
Fractured/broken bones in last 5 years	0.9	1.2	1.5	0.9	1.2
Unable to work because of sickness or disability	0.9	1.2	1.9	1.4	0.7
Primary Biliary Cirrhosis	0.8	1.2	1.6	-0.9	-1.2
Blood Eosinophil Count	0.8	6.1	10.0	1.5	3.2
Number of treatments/medications taken	0.8	1.4	1.8	1.4	1.0
Diabetes (mother)	0.8	1.1	1.4	0.8	1.2
High blood pressure	0.8	2.3	4.5	2.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	-0.1	1.4
Glaucoma (self-reported)	0.8	0.9	1.8	-1.3	-0.1
Medication: Seretide 50 evohaler	0.8	1.0	1.3	-0.8	-1.1
Hypertension (Self-reported)	0.8	2.2	4.5	2.1	0.2
Breast cancer (self-reported)	0.8	0.9	1.5	0.6	-1.2
Number of self-reported non-cancer illnesses	0.8	1.4	2.1	1.4	0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.6	-0.8	-1.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.8	1.3	0.4
Neuroticism (Nagel 2018)	0.7	1.5	2.3	1.5	0.9
Reaction Time	0.7	1.3	2.2	-0.6	1.5
Coronary Artery Disease (CAD)	0.7	0.8	1.5	1.2	0.3
Height	0.7	13.0	25.6	5.1	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.0	-0.9	-1.0
Systolic blood pressure, automated reading	0.7	2.1	2.6	1.6	1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.0	-0.8	1.0
Medication: Atenolol	0.7	0.8	0.9	-0.9	0.9
Number of incorrect matches in round	0.7	1.1	1.5	-1.2	-0.8
Had menopause	0.7	0.9	1.7	1.3	0.1
Impedance of arm (right)	0.7	3.1	3.2	1.8	1.7
Father’s age at death	0.7	1.0	1.9	-1.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.4	1.2	1.0
Impedance of arm (left)	0.7	3.1	3.2	1.7	1.8
Forced vital capacity (FVC), Best measure	0.7	2.4	4.4	-0.6	-2.1
Worry too long after embarrassment	0.7	1.3	2.3	-1.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	-0.2	-1.4
Mean time to correctly identify matches	0.7	1.3	2.4	-1.5	0.5
Heart disease (mother)	0.7	0.8	1.0	-0.8	1.0
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.6	0.5	1.3
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.6	-1.9	-0.1
Depression (Nagel 2018)	0.6	0.8	1.6	1.3	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	0.9	-0.9	-0.9
Sensitivity / hurt feelings	0.6	1.1	1.6	1.3	0.8
Relative age of first facial hair	0.6	1.2	1.3	-1.1	-1.0
Vitamin and mineral supplements	0.6	0.9	1.5	0.5	1.2
Forced vital capacity (FVC)	0.6	2.3	4.5	-0.4	-2.1
Mouth/teeth dental problems	0.6	0.9	1.7	-1.3	-0.4
Depression (self-reported)	0.6	0.7	0.8	0.9	-0.8
High blood pressure (siblings)	0.6	0.9	1.8	0.3	1.3
Number of full brothers	0.6	0.7	1.3	-1.2	-0.3
Age at first live birth	0.6	1.0	2.0	1.4	-0.1
Health satisfaction	0.6	0.8	1.3	-1.2	-0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.3	-0.2	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	-0.3	-1.1
Commuting to job workplace: Cycle	0.6	0.7	1.2	-1.1	-0.4
Heel T-Score	0.5	3.8	4.5	-2.1	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	-1.3	0.3
Illnesses of siblings	0.5	0.6	0.9	-0.7	-0.9
Headache pain in last month	0.5	0.9	1.8	1.4	0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.1	-0.8	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.1	0.2	1.0
Medication: Aspirin	0.5	0.7	1.3	-1.1	-0.4
Wears glasses or contact lenses	0.5	0.6	1.2	0.3	1.1
Hearing aid user	0.5	0.6	1.1	-0.1	1.1
Impedance of whole body	0.5	2.6	4.6	-2.1	-0.7
Worry (Nagel 2018)	0.4	0.9	1.8	1.3	0.3
Triglycerides	0.4	0.6	1.0	1.0	0.5
Smoking Status	0.4	1.0	1.9	-0.3	-1.4
Respiratory disease	0.4	1.0	1.6	-1.3	0.5
Diabetes (father)	0.4	0.5	0.7	0.5	0.8
Average weekly fortified wine intake	0.4	0.4	0.8	-0.9	0.3
Relative age voice broke	0.4	0.6	1.1	-0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.5	1.2	0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.9	-0.9	-0.5
Neuroticism score	0.4	0.9	1.2	1.1	0.7
Length of working week for main job	0.4	0.4	0.7	0.4	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	1.0	0.0
Medication: Allopurinol	0.4	0.5	0.9	0.4	0.9
Had major operations	0.4	0.5	0.8	-0.9	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.5	0.7	-0.7
Illnesses of father: Heart disease	0.4	0.5	0.9	-0.2	-1.0
Medication: Bendroflumethiazide	0.4	0.6	0.9	0.4	1.0
Medication: Lisinopril	0.4	0.5	1.0	1.0	-0.1
Number of operations (self-reported)	0.4	0.5	0.7	0.6	0.9
Cholesterol lowering medication	0.4	0.6	1.1	-1.1	-0.4
Tanning	0.3	3.5	7.1	0.2	-2.7
Average weekly spirits intake	0.3	0.4	0.5	-0.7	-0.6
Angina	0.3	0.4	0.4	-0.7	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.5	0.3	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.8	-0.2
Worrier / anxious feelings	0.3	0.6	0.7	0.8	0.8
Medication: Cholesterol lowering	0.3	0.4	0.6	0.8	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-0.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.5	0.4	-0.7
Exposure to tobacco smoke outside home	0.3	0.5	0.7	0.8	-0.5
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.9	0.2
Knee pain experienced in last month	0.3	0.4	0.6	0.4	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.6	0.5	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	-0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	0.5	-0.7
Age at First Birth	0.2	0.3	0.5	0.1	0.7
Lupus	0.2	0.2	0.3	-0.5	-0.4
Neuroticism (2016)	0.2	0.3	0.6	0.4	0.7
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	0.3
Taking other prescription medications	0.2	0.3	0.4	0.6	0.5
Sitting height	0.2	1.7	3.3	0.3	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.0	1.0	0.3
Time employed in main current job	0.2	0.2	0.2	0.4	0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	0.8	-0.1
Illnesses of mother	0.2	0.3	0.4	0.3	-0.7
Peak expiratory flow (PEF)	0.2	0.5	0.5	0.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.2	0.5	0.5
Shortness of breath walking on level ground	0.2	0.2	0.2	0.5	0.4
Angina (self-reported)	0.2	0.3	0.3	-0.6	-0.5
Chest pain or discomfort	0.2	0.3	0.3	0.6	-0.5
Leg pain on walking	0.2	0.2	0.3	-0.5	-0.5
Back pain experienced in last month	0.2	0.3	0.5	0.4	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.4	0.6	0.4
Financial situation satisfaction	0.2	0.2	0.2	0.4	0.5
Medication: Blood pressure	0.2	0.4	0.7	0.9	-0.2
Illnesses of father: High blood pressure	0.2	0.3	0.5	0.3	0.7
Pain experienced in last month	0.2	0.3	0.4	-0.4	0.6
Schizophrenia (2018)	0.1	0.3	0.3	0.6	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.4	0.1
Prostate Cancer	0.1	0.2	0.4	0.0	0.6
LDL Cholesterol	0.1	0.1	0.2	-0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	0.0
Waist Hip Ratio (WHR)	0.1	0.6	0.7	0.9	0.7
Systolic Blood Pressure	0.1	0.6	1.2	-0.3	-1.1
Lung FEV1/FVC ratio	0.1	0.6	0.8	-0.5	-0.9
Hair Pigment	0.1	1.6	2.3	-1.5	1.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.1	-0.3
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.4	0.2
Severe depression (siblings)	0.1	0.2	0.3	-0.6	0.0
Supplements: Glucosamine	0.1	0.2	0.2	0.4	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.2	0.4
Asthma	0.1	0.2	0.4	-0.6	0.1
Loud music exposure frequency	0.1	0.1	0.2	-0.4	-0.2
Medication: Omeprazole	0.1	0.1	0.1	-0.2	-0.3
Medication for cholesterol	0.1	0.1	0.2	0.5	0.1
Asthma (self-reported)	0.1	0.2	0.3	-0.6	0.2
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	0.0
Age started oral contraceptive pill	0.1	0.2	0.3	-0.6	-0.0
Heart disease (siblings)	0.1	0.2	0.2	-0.4	-0.4
Ovarian Cancer	0.0	0.1	0.1	-0.2	-0.3
Neuroticism	0.0	0.1	0.2	0.4	-0.2
Hearing difficulty/problems: Yes	0.0	0.1	0.1	0.0	0.4
Maternal smoking around birth	0.0	0.0	0.1	-0.3	-0.0
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.2	-0.1
Pain all over the body in last month	0.0	0.0	0.1	0.1	-0.3
Noisy workplace	0.0	0.0	0.0	-0.2	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.0	0.2
Guilty feelings	0.0	0.0	0.0	-0.2	0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

NPIPB6

Models

Trait associations