[Hub]/) : Traits : Lung FVC : ← →

chr4:105,373,669-107,622,327

Best TWAS P=1.93e-39 · Best GWAS P=1.68e-39 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INTS12	0.06	0.06	enet	5	0.05	2.9e-07	13.1	-13.1	2.7e-39	-1.00	0.01	0.99	TRUE
2	GTEx	Adipose Subcutaneous	GSTCD	0.08	0.07	lasso	8	0.07	2.9e-06	8.9	11.2	4.0e-29	0.76	0.09	0.91	FALSE
3	GTEx	Adrenal Gland	INTS12	0.23	0.02	enet	21	0.04	1.4e-02	1.0	-8.1	3.9e-16	-0.60	0.04	0.78	FALSE
4	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-5.6	-5.3	1.1e-07	-0.22	0.09	0.14	FALSE
5	GTEx	Artery Aorta	INTS12	0.13	0.14	lasso	3	0.14	6.5e-08	12.6	-12.8	2.9e-37	-0.90	0.02	0.98	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	GSTCD	0.16	0.07	lasso	17	0.03	4.3e-02	12.4	12.6	3.9e-36	0.92	0.02	0.94	FALSE
7	GTEx	Cells Transformed fibroblasts	INTS12	0.15	0.16	lasso	9	0.17	9.5e-13	12.4	-13.0	1.3e-38	-0.96	0.05	0.95	FALSE
8	GTEx	Esophagus Muscularis	INTS12	0.12	0.10	lasso	15	0.10	1.3e-06	12.9	-12.9	7.0e-38	-0.98	0.02	0.98	FALSE
9	GTEx	Lung	NPNT	0.07	0.02	enet	24	0.04	2.3e-04	12.8	-10.0	2.1e-23	-0.82	0.03	0.94	FALSE
10	GTEx	Nerve Tibial	GSTCD	0.09	0.03	enet	16	0.02	1.3e-02	11.7	11.1	1.6e-28	0.73	0.06	0.89	FALSE
11	GTEx	Pituitary	GSTCD	0.28	0.14	lasso	5	0.09	2.8e-03	12.6	12.2	3.0e-34	0.87	0.03	0.92	FALSE
12	GTEx	Skin Sun Exposed Lower leg	GSTCD	0.08	0.02	lasso	6	0.01	3.8e-02	11.5	11.5	1.1e-30	0.78	0.02	0.97	FALSE
13	GTEx	Small Intestine Terminal Ileum	TET2	0.23	0.01	enet	20	0.01	1.7e-01	7.8	5.7	1.0e-08	0.39	0.04	0.34	FALSE
14	GTEx	Thyroid	INTS12	0.07	0.05	lasso	7	0.03	1.2e-03	12.9	-12.9	3.4e-38	-0.99	0.02	0.97	FALSE
15	METSIM	Adipose	INTS12	0.05	0.02	blup	479	0.02	3.6e-04	8.2	-7.1	1.7e-12	-0.51	0.41	0.25	FALSE
16	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS12	0.04	0.03	blup	51	0.04	3.9e-04	12.4	-12.3	5.3e-35	-0.92	0.01	0.96	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS12	0.04	0.03	blup	49	0.04	7.1e-08	12.6	-12.7	3.5e-37	-0.93	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS12	0.12	0.06	blup	50	0.08	1.2e-04	12.9	-12.3	8.1e-35	-0.88	0.01	0.98	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS12	0.03	0.02	blup	49	0.02	6.4e-03	12.9	-12.5	7.3e-36	-0.91	0.01	0.87	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS12	0.08	0.10	lasso	2	0.10	2.9e-11	12.8	-12.8	9.6e-38	-0.98	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS12	0.32	0.00	blup	49	0.06	1.8e-04	12.6	-10.2	1.9e-24	-0.73	0.01	0.80	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSTCD	0.07	0.05	lasso	4	0.04	6.6e-05	13.1	13.1	1.9e-39	0.99	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	INTS12	0.08	0.10	enet	11	0.10	9.9e-12	12.9	-12.7	3.4e-37	-0.97	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	INTS12	0.03	0.01	blup	49	0.03	6.0e-03	6.3	-10.4	3.7e-25	-0.79	0.02	0.64	FALSE
25	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS12	0.22	0.15	lasso	6	0.16	2.3e-07	12.4	-12.5	8.6e-36	-0.89	0.02	0.96	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS12	0.15	0.11	lasso	3	0.17	2.1e-17	6.6	-11.1	1.2e-28	-0.78	0.05	0.95	FALSE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSTCD	0.04	0.06	lasso	1	0.05	9.1e-05	12.6	12.6	1.7e-36	0.95	0.02	0.95	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	INTS12	0.11	0.09	blup	49	0.11	1.3e-10	12.9	-12.2	5.4e-34	-0.89	0.01	0.99	FALSE