Hub : Genes

NPNT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2780	0.0710	3.6e-06	0.006	NA	0.052	NA	0.042	1.4e-01	NA	7.4e-04	NA	2.4e-03
2	GTEx	Esophagus Mucosa	0.0600	0.0290	3.5e-03	0.059	NA	0.034	NA	0.052	8.9e-05	NA	2.3e-03	NA	2.2e-04
3	GTEx	Lung	0.0692	0.0301	3.7e-03	0.021	NA	0.045	NA	0.032	9.5e-03	NA	2.3e-04	NA	1.7e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0309	0.0170	8.0e-03	0.005	0.016	0.025	NA	0.021	8.6e-02	5.6e-03	7.7e-04	NA	1.9e-03
5	TCGA	Brain Lower Grade Glioma	0.0449	0.0198	3.8e-04	0.045	0.035	0.035	NA	0.034	6.3e-06	6.6e-05	6.3e-05	NA	8.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.9	1.3	3.8	-1.2	-0.8	-0.9	-0.1	-1.9
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	-0.1	0.5	-1.7	-0.8	-0.6
Depressed Affect (Nagel 2018)	0.7	1.4	3.8	1.7	0.3	0.1	-0.5	1.9
Depression (Nagel 2018)	0.3	0.4	1.2	0.7	-0.1	1.1	0.1	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.7	-1.0	1.5	0.3	-0.5	-1.9
Neuroticism (Nagel 2018)	0.5	1.2	3.6	0.4	1.3	-0.2	-0.6	1.9
Schizophrenia (2018)	0.6	1.2	2.1	0.8	1.4	-1.4	-0.9	0.8
Schizophrenia vs Biploar Disorder	0.6	0.7	1.6	1.3	0.6	0.6	-0.3	1.1
Worry (Nagel 2018)	0.7	1.5	2.7	-1.6	0.9	-1.1	1.1	1.3
Alzheimer’s Disease (in mother)	0.7	0.8	1.9	1.4	1.3	-0.7	-0.3	-0.2
Alzheimer’s Disease (in father)	1.2	1.3	2.5	-0.8	-0.0	-1.4	1.6	1.1
Alzheimer’s Disease (including proxy)	0.7	1.1	2.2	1.1	1.5	-1.2	0.5	0.6
Crohns Disease (2017)	0.2	0.3	1.4	0.3	1.2	0.1	-0.1	0.4
Irritable Bowel Disease (IBD)	0.3	0.8	2.2	0.2	1.5	-1.1	-0.8	0.1
Ulcerative Colitis (UC)	0.5	0.9	2.2	0.1	1.1	-1.5	-0.9	-0.4
Major Depression (MDD)	0.8	1.0	2.9	-0.1	1.7	-1.1	-0.1	0.9
Reaction Time	0.4	0.7	2.4	-1.6	0.0	0.2	-0.6	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.6	0.2	1.6	0.8	-1.0	-1.1
Breast Cancer	0.5	1.3	3.1	1.4	0.1	0.4	-1.8	1.1
Ovarian Cancer	0.8	1.0	2.2	-0.2	-1.2	-0.6	1.5	-1.1
Prostate Cancer	0.8	1.1	2.8	-1.3	-0.7	-1.7	0.2	-0.8
Age at First Birth	0.1	0.1	0.4	-0.3	0.5	0.1	-0.6	0.0
Bipolar Disorder (2011)	4.3	4.1	10.4	-3.2	-1.7	-2.3	1.4	-0.6
Body Mass Index (BMI) (2010)	1.0	1.4	4.1	0.7	-0.7	1.2	0.6	2.0
Coronary Artery Disease (CAD)	2.8	3.4	5.2	2.1	1.4	2.3	1.2	2.0
Crohns Disease (2012)	0.6	0.9	3.0	-0.3	0.9	1.7	0.8	0.5
Mean Putamen Volume	0.1	0.2	0.5	-0.1	-0.4	0.7	0.2	-0.3
Fasting Glucose	0.2	0.2	0.8	0.1	-0.9	-0.5	0.2	0.3
HbA1C	0.8	0.9	2.0	-0.1	-1.4	-1.2	-0.8	0.2
HDL Cholesterol	0.5	0.8	1.2	0.8	1.0	0.7	1.1	0.9
LDL Cholesterol	1.1	1.7	4.1	1.5	-2.0	-0.6	-1.3	-0.3
Lupus	0.9	1.3	6.0	-2.5	0.2	-0.2	0.3	-0.6
Neuroticism (2016)	1.9	2.8	4.6	-2.1	1.1	-1.8	1.1	1.9
Primary Biliary Cirrhosis	0.4	0.6	1.5	-0.5	1.1	0.2	-1.2	0.2
Rheumatoid Arthritis	0.4	0.6	2.0	0.9	-0.1	0.5	0.1	1.4
Schizophrenia (2014)	0.5	1.2	2.3	1.1	1.1	-1.5	-0.0	1.1
Triglycerides	0.2	0.3	0.6	0.4	-0.8	0.4	-0.8	0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.6	0.7	-2.1	0.3	0.4	-0.2
Ulcerative Colitis	0.3	0.5	1.2	0.2	0.9	0.1	-1.1	0.7
Blood Eosinophil Count	0.3	2.5	5.2	2.3	-0.2	2.1	-1.3	1.1
Blood Platelet Count	0.2	2.5	4.9	-0.1	-2.0	-1.6	1.0	-2.2
Blood Red Count	0.2	2.0	7.2	1.1	2.7	0.0	-1.2	-0.4
Blood White Count	0.1	0.5	1.1	0.2	-0.3	-0.8	0.8	-1.0
Heel T-Score	0.2	1.3	4.8	0.5	2.2	0.5	0.7	-1.0
BMI	0.3	1.6	5.2	1.6	-0.3	-0.4	-0.2	2.3
Height	0.2	3.9	15.1	-0.3	-3.9	-0.3	-1.4	-1.5
Waist Hip Ratio (WHR)	0.1	0.3	0.6	0.8	-0.1	0.3	0.8	-0.5
Systolic Blood Pressure	1.2	6.1	14.2	-1.4	-3.8	0.5	-0.7	3.7
Smoking Status	0.6	1.5	5.0	-0.6	-0.8	-1.1	0.4	2.2
Allergy or Eczema	0.9	2.3	7.3	-1.0	2.7	-0.9	0.4	-1.5
Cardiovascular Disease	1.4	4.7	19.9	-0.9	-1.6	-0.5	-0.2	4.5
Hypothyroidism (self reported)	0.9	2.1	4.0	1.9	-0.3	2.0	-1.2	1.1
Respiratory disease	1.5	3.3	6.0	-1.7	1.8	2.5	1.0	-1.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.0	0.1	-1.4	0.2	0.3	0.7
Lung FEV1/FVC ratio	6.0	30.2	55.5	6.7	-4.2	-5.1	-2.8	7.5
Lung FVC	4.5	23.0	99.4	0.4	-1.8	-10.0	0.1	3.5
Neuroticism	0.8	1.9	4.5	0.3	1.9	-0.6	-1.0	2.1
Chronotype (morning person)	0.4	0.8	1.3	0.9	-1.1	0.5	0.8	1.1
Hair Pigment	0.1	2.7	4.6	-1.3	-2.1	0.9	1.8	-1.7
Tanning	0.0	0.6	1.7	0.8	-0.2	-0.6	-1.3	0.5
Hand grip strength (left)	0.5	1.3	3.2	1.0	-1.5	-0.5	-1.8	0.0
Number of treatments/medications taken	0.5	1.0	4.6	-2.1	0.1	0.2	0.3	0.2
Average weekly spirits intake	1.1	1.3	5.9	-0.7	-2.4	-0.5	-0.1	0.1
Sensitivity / hurt feelings	0.8	1.3	4.3	-0.9	0.8	-0.5	-0.8	2.1
Frequency of depressed mood in last 2 weeks	1.0	1.3	3.9	2.0	0.8	0.5	-0.7	1.2
Hearing difficulty/problems: Yes	0.5	0.8	3.4	0.1	-1.8	0.6	0.2	-0.5
Relative age of first facial hair	3.1	6.5	9.8	-2.9	-3.1	-1.8	-1.4	-3.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.3	0.7	0.2	1.3	-1.5	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.9	1.4	0.8	0.0	0.2	-0.3
Ever had hysterectomy (womb removed)	2.9	3.3	8.7	-0.1	1.5	-1.9	1.4	2.9
Systolic blood pressure, automated reading	0.7	2.2	5.7	-0.8	-2.1	-0.5	0.2	2.4
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.2	-0.8	-1.5	-1.5	-0.1	0.5
Angina	0.2	0.3	1.0	-1.0	0.3	0.2	0.5	0.1
Medication for hormone replacement therapy	0.7	0.8	3.2	0.4	-1.8	0.6	-0.3	-0.5
Vitamin and mineral supplements	0.5	0.7	1.4	1.2	0.8	1.0	0.4	0.3
Supplements: Zinc	1.0	1.1	2.4	0.6	1.5	1.6	-0.6	-0.2
Medication: Co-codamol	1.9	2.3	8.1	-2.8	-1.4	-0.4	1.0	-0.1
Medication: Metformin	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.5	0.4
Diabetes (father)	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.0	0.1
Diabetes (mother)	0.6	0.8	2.0	-1.0	-0.7	-1.4	-0.2	-0.4
Severe depression (siblings)	1.6	1.7	3.3	1.0	1.5	-1.0	-1.0	1.8
Pack years adult smoking proportion	1.1	1.7	3.0	-1.1	-0.8	1.2	1.7	-1.4
Impedance of leg (right)	0.7	3.3	9.0	-2.7	-0.4	-0.5	0.5	-3.0
Leg fat-free mass (left)	0.4	2.1	3.1	1.7	-1.6	0.8	-1.0	1.8
Trunk fat percentage	0.1	0.4	0.8	-0.1	-0.9	0.4	0.7	0.6
Hand grip strength (right)	0.4	1.0	1.8	0.5	-1.3	0.6	-1.3	-0.8
Townsend deprivation index at recruitment	2.1	3.0	6.9	-2.6	-1.6	0.1	0.3	-2.3
Current tobacco smoking	0.9	1.5	4.4	-1.4	-2.1	0.0	1.0	-0.1
Average weekly fortified wine intake	0.4	0.4	1.1	-0.3	0.9	-0.4	-0.0	1.1
Maternal smoking around birth	0.5	0.8	2.7	0.7	-1.6	0.8	0.0	-0.3
Fed-up feelings	0.4	0.8	2.5	1.0	0.5	0.3	-0.0	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.2	1.9	-0.8	2.0	-1.0	0.2
Relative age voice broke	1.8	2.7	6.6	-2.6	-2.2	-0.9	-0.4	-1.0
Taking other prescription medications	0.5	0.8	1.8	-1.3	0.4	1.1	0.9	0.0
Age when periods started (menarche)	0.6	1.5	5.6	-0.3	2.4	-0.8	-0.8	-0.6
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	6.5	2.5	1.2	-0.2	-0.6	2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.0	1.1	2.0	0.9	1.1	-1.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	5.2	-0.9	-2.3	0.8	1.5	-2.2
Qualifications: CSEs or equivalent	0.2	0.3	0.9	-0.4	-0.0	-0.6	-1.0	0.2
Serious illness, injury or assault to yourself	0.4	0.5	1.4	-0.6	-0.1	1.2	0.7	-0.4
High blood pressure	1.1	3.2	13.7	0.4	-1.4	-0.2	-0.4	3.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.7	-0.7	1.6	-0.1	-0.4	-1.0
Multivitamins +/- minerals	0.4	0.5	1.3	-0.5	-0.0	-1.1	-0.1	-1.0
Stomach or abdominal pain in last month	0.5	0.7	1.2	0.8	0.8	-0.7	1.1	-0.6
Supplements: Glucosamine	0.3	0.5	1.8	-0.2	-0.2	-1.4	-0.0	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.5	0.1	1.2	0.3	-0.6	-1.2
Medication: Atenolol	1.3	1.7	3.7	-1.7	-0.5	-0.6	1.0	1.9
Medication: Levothyroxine sodium	0.3	0.6	0.8	0.8	-0.3	0.9	0.8	0.7
Sitting height	0.3	2.1	5.3	-0.2	-2.3	-0.1	-2.2	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.0	0.5	0.7	-0.2	0.7
High blood pressure (mother)	0.6	0.8	1.8	0.5	-1.4	-0.5	-1.3	-0.5
Body mass index (BMI)	0.3	1.3	4.1	1.6	0.1	0.1	0.0	2.0
Impedance of leg (left)	1.0	4.7	14.0	-2.9	-0.7	-0.4	0.7	-3.7
Leg predicted mass (left)	0.4	2.0	3.1	1.8	-1.5	0.8	-1.0	1.7
Trunk fat mass	0.2	0.7	2.6	0.2	-1.6	0.1	0.3	0.9
Waist circumference	0.4	1.3	4.3	1.4	0.2	-0.0	0.5	2.1
Number of incorrect matches in round	0.4	0.6	1.8	-0.6	0.4	-0.2	-1.3	0.7
Past tobacco smoking	0.8	1.6	7.0	-0.2	-0.2	0.8	0.1	-2.7
Alcohol usually taken with meals	0.4	0.6	1.2	0.6	-0.3	-0.6	-1.1	1.1
Nervous feelings	1.3	2.4	5.1	-2.1	0.8	-2.3	1.1	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	0.3	-0.9	0.4	-0.2	0.3
Hearing difficulty/problems with background noise	0.4	0.6	1.5	-0.5	-1.0	-0.3	1.2	-0.5
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.5	1.1	0.1	0.4	-0.7
Had menopause	0.1	0.2	0.4	0.6	-0.5	0.0	0.1	-0.6
Had other major operations	1.1	1.3	4.2	0.8	-0.0	2.0	1.3	-0.2
Forced vital capacity (FVC)	1.9	7.2	27.7	0.1	-2.3	-5.3	-0.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.4	0.6	1.6	0.4	0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	4.7	-1.9	-0.4	0.4	2.2	0.2
Qualifications: None of the above	0.3	0.5	1.4	-0.5	-0.7	-0.5	1.2	0.6
Financial difficulties in last 2 years	0.2	0.3	0.6	0.8	-0.3	0.7	0.5	-0.2
Mouth/teeth dental problems	0.5	0.8	1.3	1.2	1.1	1.0	0.3	0.5
Heart attack	0.7	0.9	2.6	-1.6	-1.0	0.6	-0.0	0.5
Allergy	0.7	1.7	4.0	0.8	-2.0	-1.0	-0.7	1.6
Pain all over the body in last month	0.8	0.9	2.4	1.5	-0.0	-1.4	0.3	0.0
Diabetes (self-reported)	0.2	0.2	0.5	0.7	0.1	0.7	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	-0.7	1.0	-0.2	0.0	-0.6
Medication: Ramipril	0.4	0.5	1.0	0.8	-0.8	1.0	-0.4	0.5
Medication: Simvastatin	0.7	1.0	1.6	-0.3	-1.2	0.5	1.2	1.2
Fluid intelligence score	0.4	0.9	2.6	-0.9	-0.5	0.8	-0.2	-1.6
Illnesses of siblings	1.2	1.7	4.7	-1.6	0.2	0.9	0.6	-2.2
Neuroticism score	0.7	1.5	3.5	-0.2	1.8	-0.6	-0.5	1.9
Weight	0.3	1.3	2.4	1.2	-1.6	0.1	-0.5	1.5
Impedance of arm (right)	0.3	1.3	3.2	-1.8	-0.0	1.1	0.8	-1.3
Arm fat percentage (right)	0.2	0.9	3.3	0.5	-0.2	0.5	0.7	1.8
Trunk fat-free mass	0.3	1.9	3.7	1.4	-1.9	-0.1	-1.5	1.4
Hip circumference	0.2	1.0	3.6	0.8	-0.6	-0.5	-0.4	1.9
Time employed in main current job	0.4	0.5	1.7	0.3	-0.7	-0.0	-1.3	0.5
Alcohol intake versus 10 years previously	1.3	2.0	4.5	2.1	1.7	1.5	-0.5	0.4
Father’s age at death	1.3	1.8	4.0	-2.0	-0.2	-2.0	1.0	0.0
Worrier / anxious feelings	0.4	0.8	1.6	-1.1	1.3	-0.7	-0.5	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.9	0.9	0.6	0.7	-2.0	0.5
Falls in the last year	0.3	0.4	1.1	1.1	0.6	0.6	-0.2	-0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.6	0.3	-1.0	1.1	0.7
Number of live births	0.9	1.3	4.6	-0.3	1.3	-0.2	2.2	0.2
Forced expiratory volume in 1-second (FEV1)	3.3	11.2	32.8	1.9	-3.3	-5.7	-1.1	2.7
Pulse rate	0.3	0.5	2.2	-0.1	1.5	0.6	-0.1	-0.1
Happiness	0.7	0.9	2.1	-0.6	-0.4	-0.7	-1.5	-1.1
Noisy workplace	1.4	1.7	3.5	1.9	1.6	0.8	-1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	6.8	0.4	1.2	-0.1	-2.6	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	1.4	0.3	0.5	1.3	0.9
Mouth/teeth dental problems: Dentures	1.4	2.3	6.2	-1.3	0.0	-1.6	1.0	2.5
Asthma	1.6	3.1	10.3	-0.9	1.2	3.2	0.9	-1.4
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	7.1	1.4	1.5	0.1	-2.7	-0.4
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.8	-1.1	0.3	0.2	0.8
Depression (self-reported)	0.8	1.0	2.6	-0.1	0.1	1.6	0.1	1.4
Medication: Lansoprazole	1.9	2.2	4.7	0.7	2.2	-1.7	-1.6	0.2
Prospective memory result	0.6	0.7	2.3	1.1	1.5	0.1	0.1	0.1
Lung cancer (father)	1.8	2.1	8.5	0.0	-2.9	0.2	-0.2	-1.4
Illnesses of mother	0.8	1.0	2.3	-0.7	-0.3	1.5	1.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.1	31.5	1.8	-3.8	-5.6	-1.1	3.1
Pulse wave Arterial Stiffness index	0.9	1.1	2.8	1.7	0.5	-0.8	-1.3	-0.2
Impedance of arm (left)	0.4	1.8	4.2	-2.0	-0.7	1.1	0.6	-1.6
Arm fat mass (right)	0.2	0.9	3.2	0.8	-0.7	0.2	0.2	1.8
Trunk predicted mass	0.3	1.9	3.5	1.5	-1.9	0.1	-1.5	1.4
Standing height	0.4	3.6	13.7	-0.8	-3.7	-0.0	-1.5	-1.3
Length of working week for main job	0.9	1.0	2.9	0.4	0.7	-1.0	-1.7	0.6
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.4	-0.4	-1.1	-1.2	0.1
Breastfed as a baby	0.8	1.0	2.5	1.6	0.6	0.8	-1.1	0.3
Tense / ‘highly strung’	1.6	2.6	6.5	-1.6	1.5	-0.5	1.3	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	-0.6	0.4	-0.4	-0.1	1.3
Hair/balding pattern: Pattern 4	0.8	1.8	6.8	1.2	2.6	-0.4	0.3	0.9
Birth weight of first child	0.7	1.2	4.5	2.1	1.0	-0.2	0.6	-0.2
Peak expiratory flow (PEF)	1.1	2.5	4.9	1.7	-2.2	-1.8	-0.3	1.2
Pulse wave reflection index	0.3	0.4	1.6	0.3	-0.0	-1.3	-0.2	-0.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.8	-0.3	-1.1	-1.2	0.8	-1.7
Loud music exposure frequency	0.7	0.8	2.8	0.0	-0.1	0.5	0.9	-1.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.9	-0.5	0.7	-0.9	-1.4	0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.8	1.1	-0.0	1.0	-1.3	-1.1
Blood clot in the leg (DVT)	1.2	1.5	2.8	1.6	0.4	-1.7	0.5	1.3
Medication: Paracetamol	0.8	1.3	2.6	1.0	1.3	0.3	-1.6	-1.0
Headache pain in last month	1.4	2.5	6.7	2.6	0.7	0.9	-2.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	4.1	-0.1	2.0	-0.3	0.5	-1.4
Glaucoma (self-reported)	0.6	0.7	1.9	-0.4	-1.4	-0.8	0.9	-0.3
Gout (self-reported)	0.5	0.6	1.6	-1.3	0.0	0.6	0.4	-1.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.4	7.5	2.7	0.6	1.7	-0.9	0.9
Medication: Amlodipine	0.2	0.3	0.7	0.5	-0.4	0.2	-0.7	0.9
Medication: Ventolin 100micrograms inhaler	1.4	1.9	5.4	-0.9	1.3	2.3	-0.3	-1.2
Birth weight	1.5	3.2	7.8	-1.7	-1.9	0.5	2.8	-1.2
Chronic bronchitis/emphysema (mother)	1.4	1.6	2.6	1.3	1.5	0.7	-0.9	1.6
High blood pressure (siblings)	1.8	2.5	9.6	-0.5	-0.9	-0.8	1.2	3.1
Forced vital capacity (FVC), Best measure	2.1	7.9	27.7	-0.3	-3.2	-5.3	-0.2	1.1
Body fat percentage	0.1	0.5	1.2	-0.2	-0.8	0.2	1.1	0.8
Leg fat percentage (right)	0.2	0.6	1.3	-0.2	-0.7	-0.5	1.1	0.9
Arm fat-free mass (right)	0.2	1.2	3.8	1.2	-1.9	0.0	-1.0	0.3
Exposure to tobacco smoke outside home	1.2	1.6	3.3	-1.8	-1.7	-0.3	1.3	-0.5
Comparative body size at age 10	1.6	4.5	14.5	-2.6	-1.0	0.4	3.8	0.1
Number of full brothers	0.5	0.6	1.4	0.2	0.0	-1.1	-1.2	0.6
Worry too long after embarrassment	0.6	1.0	2.1	0.8	1.4	-0.3	-1.5	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.7	-1.1	0.6	0.5	0.2	1.7
Wheeze or whistling in the chest in last year	0.9	1.5	3.5	-1.9	0.5	1.1	1.2	-1.1
Number of children fathered	1.1	1.2	4.5	1.1	0.3	-0.2	-0.6	2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.7	-0.1	0.4	-1.1	-0.5	1.6
Age at first live birth	1.0	1.7	3.1	1.2	0.5	1.8	-1.0	-1.7
Pulse wave peak to peak time	1.2	1.5	4.2	-2.0	-0.8	0.9	1.3	0.1
Health satisfaction	0.5	0.7	2.6	-0.1	0.2	-1.6	0.9	0.0
Shortness of breath walking on level ground	0.2	0.3	1.3	-1.1	-0.1	0.1	0.3	0.2
Qualifications: College or University degree	0.2	0.5	1.4	-0.1	0.2	1.0	-0.6	-1.2
Eye problems/disorders: None of the above	1.5	1.7	4.3	2.1	1.5	1.3	0.2	0.3
Mouth/teeth dental problems: Loose teeth	1.6	1.9	8.6	-0.4	-2.9	0.8	-0.4	0.0
Emphysema/chronic bronchitis	1.1	1.2	2.0	-0.9	1.4	1.1	0.6	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	0.3	-0.4	1.1	0.8	0.7
Neck or shoulder pain in last month	0.9	1.2	3.1	-0.7	-0.8	1.8	-0.4	-1.3
Medication: Blood pressure	0.9	1.7	3.8	0.4	-1.8	0.8	-0.6	2.0
Angina (self-reported)	0.4	0.5	1.7	-1.3	0.1	0.1	0.8	-0.1
Migraine (self-reported)	0.1	0.2	0.3	0.5	-0.0	0.4	0.4	-0.5
Medication: Ibuprofen	1.0	1.2	4.6	0.5	1.0	-0.1	-2.1	-0.5
Medication: Allopurinol	0.2	0.3	0.9	-0.9	-0.3	0.5	0.0	-0.6
Medication: Omeprazole	0.6	0.7	1.5	-1.2	-1.2	-0.6	0.1	-0.4
Medication: Seretide 50 evohaler	0.8	1.0	1.7	-0.4	0.9	1.3	0.7	-1.3
Mean time to correctly identify matches	0.5	1.0	2.6	-1.6	1.0	-0.1	0.5	1.1
Heart disease (mother)	2.0	2.4	5.4	-1.9	-0.4	-2.3	-0.8	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	4.1	0.4	0.9	1.4	-2.0	-1.0
Whole body fat mass	0.2	0.7	1.8	0.4	-1.4	0.2	0.5	1.1
Leg fat mass (right)	0.2	0.7	1.5	0.5	-1.1	-0.1	0.7	1.2
Arm predicted mass (right)	0.3	1.4	3.8	1.5	-1.9	0.2	-0.8	0.5
Pulse rate, automated reading	0.2	0.6	2.0	-0.2	1.4	0.2	-0.6	-0.7
Alcohol intake frequency.	2.1	4.8	9.9	2.9	3.1	1.6	-1.6	0.4
Comparative height size at age 10	0.2	1.2	2.9	0.9	-1.6	1.7	0.2	0.2
Number of full sisters	1.5	1.8	3.3	-1.6	-1.4	-0.6	-0.8	1.8
Suffer from ‘nerves’	0.4	0.6	0.9	-1.0	0.9	-0.4	0.7	0.6
Overall health rating	0.5	1.0	3.0	-1.7	-0.5	-1.1	0.7	-0.2
Chest pain or discomfort	1.2	1.7	8.4	-2.9	-0.1	0.1	0.1	-0.4
Had major operations	0.9	1.0	2.1	-1.4	0.6	-0.9	0.2	-1.4
Age at last live birth	1.0	1.4	2.1	1.2	1.1	1.4	0.6	-1.5
Family relationship satisfaction	1.1	1.3	2.2	-0.6	-1.4	-1.3	-0.6	-1.5
Leg pain on walking	1.6	2.0	5.8	2.4	-0.3	0.2	1.7	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.6	-0.1	-1.3	-0.7	0.4	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.6	-0.7	0.1	0.4	1.3	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.6	-0.4	0.2	-0.4	-1.6	0.0
Medication: Aspirin	0.5	0.7	2.1	-1.5	-0.3	-0.6	1.0	-0.1
Supplements: Vitamin C	0.8	0.9	2.6	0.5	-0.5	1.1	-0.5	1.6
Knee pain experienced in last month	0.6	1.0	1.7	0.6	-1.2	1.0	-0.5	-1.3
Hypertension (Self-reported)	1.5	4.3	18.6	0.8	-1.2	-0.2	-0.9	4.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.8	-0.8	0.6	-1.7	1.9	-0.3
Illnesses of father: Heart disease	0.2	0.3	0.9	1.0	0.6	0.2	-0.0	0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.6	-0.2	0.0	-0.4	0.1	0.7
Smoking status: Previous	1.1	1.6	5.4	0.8	1.1	-0.6	0.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	13.3	-1.3	-3.6	-0.4	-1.1	-0.9
Whole body fat-free mass	0.3	1.8	2.9	1.6	-1.7	0.5	-1.3	1.3
Leg fat-free mass (right)	0.4	2.0	3.2	1.8	-1.6	1.0	-1.1	1.4
Arm fat percentage (left)	0.2	0.8	2.9	0.5	-0.6	0.6	0.5	1.7
Average weekly red wine intake	1.0	1.5	5.3	-0.3	-2.3	0.5	-0.5	-1.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-0.2	0.3	-1.1	-1.0	-0.0
Mood swings	0.6	1.0	3.9	0.0	0.8	0.5	0.4	2.0
Loneliness, isolation	2.2	3.0	8.4	2.9	1.6	1.0	-1.1	1.4
Long-standing illness, disability or infirmity	1.6	2.5	4.8	-1.3	-2.2	1.1	0.2	-2.1
Ever had bowel cancer screening	1.2	1.5	6.3	0.6	2.5	-0.0	-0.4	-0.7
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.4	-0.5	0.6	0.6	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.1	-0.4	-0.1	0.8	-0.9
Friendships satisfaction	0.5	0.6	1.6	-0.8	-0.1	-1.3	-0.4	-0.9
Qualifications: nursing, teaching	0.9	1.5	5.0	0.2	2.2	0.6	-0.3	-1.4
Commuting to job workplace: Walk	0.4	0.5	0.9	-0.0	0.2	-0.9	-0.8	1.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.0	-0.1	-0.5	-0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	3.4	-0.2	0.5	-0.9	-1.2	-1.9
Medication for cholesterol	0.3	0.5	1.0	1.0	1.0	0.3	-0.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.2	1.0	-0.3	2.1	-0.3	-0.3
Back pain experienced in last month	0.6	0.9	2.5	-0.7	0.5	0.6	-1.1	1.6
Mineral and other dietary supplements	0.3	0.5	1.1	1.1	0.6	0.3	-0.4	0.7
Breast cancer (self-reported)	0.6	0.7	1.7	-1.3	-0.7	0.2	0.4	-1.1
Asthma (self-reported)	1.6	3.1	10.6	-0.4	1.4	3.3	0.8	-1.5
Osteoporosis (self-reported)	0.6	0.8	1.3	0.8	0.8	0.3	-1.1	1.1
Osteoarthritis (self-reported)	1.2	1.6	3.8	0.5	1.4	0.2	-1.9	-1.4
Medication: Aspirin	0.5	0.6	1.8	-1.4	0.1	-0.3	1.0	-0.2
Medication: Gliclazide	1.6	1.8	5.5	-0.4	-2.3	0.6	-0.5	-1.7
Illnesses of father: None of the above (group 1)	1.1	1.3	4.7	-0.7	0.0	0.4	1.1	-2.2
Smoking status: Current	0.9	1.4	4.4	-1.4	-2.1	-0.4	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.6	24.5	1.5	-2.0	-5.0	0.2	3.6
Whole body water mass	0.3	1.7	3.4	1.4	-1.8	0.4	-1.1	1.3
Leg predicted mass (right)	0.4	2.0	3.1	1.8	-1.6	1.1	-1.1	1.4
Arm fat mass (left)	0.3	1.1	3.6	0.8	-0.9	0.4	0.2	1.9
Number of self-reported non-cancer illnesses	0.3	0.6	2.2	0.2	0.0	-0.0	-0.9	1.5
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.2	-0.9	0.2	-0.5	0.5
Miserableness	0.4	0.8	1.6	0.7	1.0	-0.3	-1.2	0.9
Guilty feelings	0.1	0.2	0.4	0.4	0.6	0.6	0.0	0.4
Wears glasses or contact lenses	0.5	0.5	1.4	0.6	1.2	-0.2	0.9	0.3
Ever taken oral contraceptive pill	0.5	0.6	1.6	0.1	-1.2	0.0	-1.2	0.2
Hearing aid user	0.9	1.0	3.8	-0.5	-1.9	0.9	0.2	0.5
Mother’s age at death	1.0	1.2	4.7	-2.2	-0.9	-0.5	0.5	-0.1
Financial situation satisfaction	0.4	0.5	1.2	0.2	-0.6	-1.1	-0.7	-0.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.2	0.6	-1.3	0.5	-1.5	1.3
Commuting to job workplace: Public transport	0.8	0.9	1.9	1.4	-1.0	0.7	-0.9	-0.5
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	-0.5	-1.2	-0.8	0.4	-0.2
Medication: Blood pressure	1.1	2.2	4.9	-1.2	-1.1	-1.7	0.6	2.2
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.6	0.3	-1.2	0.4	-0.6	-0.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.7	-0.5	-1.2	0.4	0.8	-1.3
High cholesterol (Self-reported)	0.3	0.4	1.1	-0.7	-0.7	0.2	0.3	1.0
Medication: Bendroflumethiazide	2.0	3.0	4.8	-1.9	-0.7	-1.4	2.2	2.1
Medication: Paracetamol	0.7	1.1	2.5	0.8	1.2	-0.3	-1.6	-1.0
Medication: Lisinopril	0.6	0.7	1.4	1.2	0.6	0.4	-0.9	1.0
Medication: Atorvastatin	1.0	1.3	3.0	-1.5	-0.2	-0.4	-1.7	-0.9
Illnesses of father: High blood pressure	0.5	0.6	1.9	-0.3	-1.4	-0.6	-0.9	-0.1
Alcohol drinker status: Never	1.1	1.3	3.0	1.7	1.3	0.1	-0.9	1.0
Ever smoked	0.6	1.0	2.9	-0.7	-0.5	-1.1	-0.2	1.7
Basal metabolic rate	0.3	1.8	3.2	1.5	-1.8	0.4	-1.2	1.4
Leg fat percentage (left)	0.2	0.6	1.6	-0.2	-0.7	-0.7	1.3	0.4
Arm fat-free mass (left)	0.2	1.0	2.0	1.4	-1.4	0.1	-0.7	0.9
Number of operations (self-reported)	0.4	0.6	1.3	-0.1	0.7	0.0	1.2	-1.0
Average weekly beer plus cider intake	0.4	0.6	0.9	-0.8	-0.3	-0.7	-0.9	0.9
Irritability	0.8	1.4	3.4	0.4	1.9	0.8	-0.8	1.4
Risk taking	0.1	0.2	0.6	-0.1	0.1	-0.6	0.3	0.8
Ever had prostate specific antigen (PSA) test	1.7	2.0	6.1	-0.6	-2.5	-0.7	0.2	-1.7
Fractured/broken bones in last 5 years	0.4	0.5	1.7	-0.0	-0.6	1.3	0.4	-0.1
Age started oral contraceptive pill	0.4	0.5	1.8	0.4	1.4	-0.1	0.5	-0.4
Diastolic blood pressure, automated reading	0.9	2.9	6.0	-0.5	-2.4	-1.1	-1.9	1.9
Ever depressed for a whole week	1.7	2.1	4.9	-2.2	-0.9	-1.9	0.9	-0.1
Unable to work because of sickness or disability	1.7	2.3	5.9	-0.4	-2.1	0.5	2.4	0.7
Commuting to job workplace: Cycle	0.4	0.5	2.0	-0.1	0.1	0.1	0.5	1.4
Myopia	0.2	0.3	0.8	0.5	0.6	-0.3	-0.9	0.4
Vascular/heart problems diagnosed by doctor	1.0	2.7	10.8	0.2	1.5	-0.5	0.1	-3.3
Cholesterol lowering medication	0.5	0.8	1.8	-0.9	-0.5	1.0	1.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.1	-1.8	-1.5	-0.2	0.4	0.2
Pain experienced in last month	0.6	1.0	1.6	-1.3	-0.1	-1.2	0.9	1.0
Supplements: Calcium	1.0	1.1	2.6	-1.6	-0.4	-0.1	-1.3	1.1
Basal cell carcinoma (self-reported)	1.5	1.8	7.0	0.9	2.6	0.5	-0.2	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.8	-1.7	-0.9	0.3	-0.0	0.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	3.6	1.9	0.4	-1.5	0.7	1.4
Heart disease (siblings)	0.3	0.4	0.8	0.9	-0.5	-0.3	-0.7	0.3
Alcohol drinker status: Previous	0.9	1.0	3.3	0.8	-0.0	-0.7	-0.6	-1.8
Pack years of smoking	1.0	1.5	2.9	-1.1	-0.6	1.1	1.7	-1.4
Impedance of whole body	0.6	3.3	8.1	-2.6	-0.9	0.3	0.8	-2.8
Leg fat mass (left)	0.2	0.6	1.2	0.7	-1.1	-0.2	0.7	1.0
Arm predicted mass (left)	0.2	0.9	1.5	1.2	-1.1	0.1	-0.6	1.1