TWAS hub - GSTCD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0750	0.0280	1.4e-04	0.070	NA	0.066	NA	0.068	2.4e-06	NA	4.7e-06	NA	2.9e-06
2	GTEx	Cells EBV-transformed lymphocytes	0.1600	0.0650	2.3e-03	0.070	NA	0.007	NA	0.028	2.7e-03	NA	1.8e-01	NA	4.3e-02
3	GTEx	Nerve Tibial	0.0894	0.0357	6.5e-04	0.028	NA	0.020	NA	0.020	4.1e-03	NA	1.3e-02	NA	1.3e-02
4	GTEx	Pituitary	0.2760	0.0950	1.2e-03	0.137	NA	0.069	NA	0.091	2.7e-04	NA	8.4e-03	NA	2.8e-03
5	GTEx	Skin Sun Exposed Lower leg	0.0770	0.0320	5.1e-04	0.016	NA	0.007	NA	0.011	1.5e-02	NA	7.3e-02	NA	3.8e-02
6	TCGA	Brain Lower Grade Glioma	0.0675	0.0422	8.5e-05	0.046	0.033	0.029	NA	0.035	6.0e-06	0.00010	2.5e-04	NA	6.6e-05
7	TCGA	Stomach Adenocarcinoma	0.0420	0.0270	6.2e-03	0.060	0.041	0.044	NA	0.054	3.8e-05	0.00061	3.6e-04	NA	9.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Lung FVC	28.6	145.6	171.6	11.2	12.6	11.1	12.2	11.5	13.1	12.6
Lung FEV1/FVC ratio	26.8	136.0	163.8	12.0	10.4	12.2	10.3	12.8	12.1	11.6
Forced expiratory volume in 1-second (FEV1)	23.8	80.2	93.3	8.8	8.9	9.2	7.8	9.1	9.7	9.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	23.5	49.7	61.6	7.0	6.8	6.8	6.3	7.1	7.9	7.5
Forced expiratory volume in 1-second (FEV1), Best measure	20.8	66.4	80.6	7.6	8.1	8.2	7.0	8.7	9.0	8.3
Forced vital capacity (FVC)	12.8	49.5	57.0	6.8	7.4	7.1	6.3	6.7	7.5	7.3
Forced vital capacity (FVC), Best measure	10.6	38.6	48.6	5.5	6.5	6.1	5.4	6.4	7.0	6.5
Asthma (self-reported)	6.2	12.3	15.7	-3.7	-3.7	-3.1	-4.0	-2.9	-3.6	-3.4
Asthma	6.1	12.0	15.6	-3.7	-3.7	-3.0	-4.0	-2.9	-3.5	-3.3
Severe depression (siblings)	6.0	6.7	10.1	3.0	2.6	2.7	2.0	3.2	2.2	2.1
Respiratory disease	5.1	11.4	13.0	-3.6	-3.3	-3.2	-3.3	-3.3	-3.6	-3.3
Irritability	5.0	8.4	10.4	-3.0	-2.7	-3.2	-3.2	-3.2	-2.6	-2.3
Peak expiratory flow (PEF)	4.7	10.9	14.8	3.8	3.3	3.6	2.4	3.1	3.5	3.1
Illness, injury, bereavement, stress in last 2 years	4.4	5.4	9.0	-2.8	-1.9	-2.8	-2.0	-3.0	-2.0	-1.2
HbA1C	4.1	4.6	6.2	2.1	1.3	2.3	1.9	2.5	2.5	2.3
Depression (self-reported)	4.1	4.9	6.5	-2.0	-2.2	-2.5	-1.7	-2.1	-2.5	-2.3
Medication: Bendroflumethiazide	3.6	5.5	9.0	2.3	2.5	1.8	3.0	2.0	2.5	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.1	7.7	-2.0	-2.2	-1.2	-2.8	-2.1	-1.9	-1.7
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.2	9.7	-3.1	-1.9	-3.1	-1.8	-2.2	-1.9	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	3.3	4.4	5.9	-2.3	-2.3	-2.4	-2.0	-1.8	-2.3	-1.4
Medication: Ventolin 100micrograms inhaler	3.2	4.1	6.1	-1.7	-2.5	-1.3	-2.3	-1.6	-2.4	-2.2
Taking other prescription medications	3.1	4.8	6.0	-2.4	-2.0	-2.3	-1.8	-2.4	-2.5	-1.9
Crohns Disease (2012)	3.0	4.9	6.0	-2.5	-2.4	-1.9	-2.1	-2.0	-2.3	-2.2
Length of working week for main job	2.8	3.1	4.5	1.8	1.3	2.1	1.1	2.1	1.8	1.9
Number of full sisters	2.8	3.3	5.2	2.1	1.8	2.3	1.7	1.9	1.4	1.4
Mood swings	2.8	5.0	9.3	-2.3	-1.8	-2.4	-1.5	-3.0	-2.2	-2.0
Medication: Blood pressure	2.8	5.3	8.0	1.9	2.4	2.1	2.8	2.1	2.4	2.3
Body Mass Index (BMI) (2010)	2.6	3.6	5.4	-1.2	-1.6	-2.3	-1.8	-2.1	-2.1	-1.9
Schizophrenia (2014)	2.6	5.7	6.4	2.0	2.4	2.5	2.2	2.5	2.5	2.4
Medication: Atenolol	2.5	3.2	5.3	2.3	1.9	1.4	1.6	1.7	1.6	1.8
Heart disease (mother)	2.4	2.9	5.3	1.2	1.8	1.1	2.3	1.1	1.8	2.1
Ever had prostate specific antigen (PSA) test	2.4	2.7	5.0	1.4	1.5	1.1	1.6	2.2	1.9	1.4
Hair/balding pattern: Pattern 3	2.3	3.4	5.2	2.3	1.5	1.9	1.4	1.8	1.9	2.0
Leg pain on walking	2.3	2.9	8.7	1.4	1.3	1.8	0.9	3.0	1.5	1.2
Alzheimer’s Disease (in mother)	2.2	2.6	4.5	1.6	1.8	1.5	2.1	0.9	1.4	1.6
Alcohol intake frequency.	2.1	4.8	7.9	-2.2	-1.8	-1.8	-1.6	-2.1	-2.7	-2.8
Had other major operations	2.0	2.4	4.6	-1.2	-1.5	-1.5	-1.1	-1.1	-2.0	-2.1
Depression (Nagel 2018)	1.9	2.9	5.8	-1.8	-1.6	-2.4	-1.7	-1.8	-1.5	-0.9
Ever highly irritable/argumentative for 2 days	1.9	2.3	3.5	1.4	1.9	1.8	1.6	1.1	1.4	1.0
Ever depressed for a whole week	1.9	2.4	4.2	1.0	2.0	1.3	2.0	0.8	1.6	1.6
Bipolar Disorder or Schizophrenia	1.8	4.3	5.3	1.4	2.1	2.2	2.0	2.1	2.3	2.2
Alzheimer’s Disease (including proxy)	1.8	2.6	4.0	1.5	2.0	1.4	2.0	1.1	1.4	1.7
Bipolar Disorder (2011)	1.8	1.7	2.6	0.6	1.5	0.7	1.6	1.1	1.5	1.6
Pulse wave reflection index	1.8	2.2	3.8	1.2	1.6	1.6	2.0	0.9	1.5	1.4
Average weekly red wine intake	1.8	2.7	3.6	-1.9	-1.8	-1.4	-1.9	-1.8	-1.3	-1.3
Neuroticism (2016)	1.7	2.4	8.3	-2.3	-0.6	-2.9	-0.3	-1.6	-0.5	-0.3
Chronic bronchitis/emphysema (father)	1.7	2.0	3.2	-1.5	-1.0	-1.6	-1.0	-1.8	-1.5	-1.3
Illnesses of siblings	1.7	2.4	3.5	-1.4	-1.6	-1.9	-1.3	-1.6	-1.5	-1.4
Bipolar Disorder (2018)	1.6	2.5	4.2	1.5	1.4	1.8	1.3	2.1	1.6	1.3
Comparative body size at age 10	1.6	4.5	8.1	-2.8	-1.9	-2.1	-0.9	-2.7	-1.8	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.6	-1.2	-1.9	-1.2	-1.5	-0.8	-1.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.0	3.3	0.9	1.5	1.5	1.4	0.8	1.7	1.8
Neuroticism (Nagel 2018)	1.5	3.4	5.7	-2.3	-1.5	-2.4	-1.5	-2.3	-1.5	-0.9
Neuroticism	1.5	3.6	7.5	-2.1	-1.6	-2.7	-1.3	-2.6	-1.4	-0.9
Multivitamins +/- minerals	1.5	2.0	2.8	1.1	1.5	1.6	1.7	1.5	1.3	1.0
Blood clot in the leg (DVT)	1.5	1.9	3.2	0.9	1.5	1.4	1.4	0.8	1.6	1.8
Number of full brothers	1.5	1.9	2.8	1.5	1.2	1.7	1.6	1.5	1.0	0.9
Number of children fathered	1.5	1.7	2.8	1.5	1.4	1.7	1.4	1.2	1.1	0.6
Pain all over the body in last month	1.4	1.5	4.5	0.5	0.8	0.6	0.6	2.1	1.5	1.4
Tense / ‘highly strung’	1.4	2.4	6.2	-1.7	-1.5	-2.5	-1.6	-1.4	-0.8	-0.3
Family relationship satisfaction	1.4	1.8	3.0	0.3	1.4	1.6	1.7	0.7	1.5	1.5
Average weekly spirits intake	1.3	1.7	2.3	1.1	1.2	1.2	1.3	1.4	1.3	1.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	2.8	-1.6	-1.3	-1.7	-0.6	-1.5	-1.2	-0.3
High blood pressure (mother)	1.3	1.9	4.4	1.5	1.0	1.5	0.6	2.1	1.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	3.5	1.6	0.9	1.9	1.1	1.2	0.7	0.0
Illnesses of mother	1.3	1.7	2.4	-0.7	-1.3	-1.1	-1.4	-1.2	-1.6	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	4.5	-2.1	-0.9	-2.0	-0.5	-1.6	-0.9	-0.8
Guilty feelings	1.3	1.9	3.1	-1.2	-1.3	-1.7	-0.9	-1.8	-1.5	-0.9
Ever had hysterectomy (womb removed)	1.2	1.3	4.4	-2.1	-0.4	-1.5	0.4	-1.5	-0.1	0.0
Worrier / anxious feelings	1.2	2.3	7.0	-1.7	-1.3	-2.7	-1.3	-1.4	-0.8	-0.6
Medication for pain relief, constipation, heartburn	1.2	2.0	3.4	-1.0	-1.8	-1.1	-1.8	-1.5	-1.2	-1.3
Chest pain or discomfort	1.2	1.7	3.1	-1.5	-1.1	-1.8	-1.1	-1.3	-1.2	-1.0
Worry (Nagel 2018)	1.1	2.4	6.9	-1.8	-1.1	-2.6	-1.1	-1.8	-0.9	-0.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.0	0.5	1.1	0.8	0.9	1.4	1.4	1.4
Number of live births	1.1	1.6	4.6	1.2	1.8	1.0	2.1	0.6	0.6	0.5
Pulse rate	1.1	1.9	2.9	-1.6	-1.5	-1.7	-1.5	-0.9	-1.1	-0.9
Exposure to tobacco smoke at home	1.1	1.2	1.9	0.4	1.4	1.0	1.3	1.0	1.2	1.1
Emphysema/chronic bronchitis	1.1	1.3	2.6	-0.8	-1.6	-0.8	-0.8	-1.2	-1.4	-1.0
Medication: Aspirin	1.1	1.5	2.8	1.0	1.3	1.1	1.7	1.0	1.2	1.0
Breast cancer (self-reported)	1.1	1.3	3.4	1.8	1.1	0.8	1.3	1.0	0.6	0.8
Medication: Lisinopril	1.1	1.5	2.7	-1.7	-1.2	-1.1	-1.4	-1.4	-0.8	-0.7
Depressed Affect (Nagel 2018)	1.0	2.1	4.7	-2.2	-1.1	-1.4	-1.0	-1.7	-1.3	-1.0
Schizophrenia (2018)	1.0	2.0	3.3	0.7	1.6	1.4	1.6	1.0	1.7	1.8
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.3	-2.1	-1.7	-1.2	-1.6	-1.2	-1.6	-1.2
Fed-up feelings	1.0	1.8	3.3	-1.8	-1.3	-1.3	-0.7	-1.6	-1.4	-1.0
Relative age voice broke	1.0	1.5	2.2	1.5	0.9	1.0	1.1	1.3	1.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.5	-1.5	-1.2	-1.9	-1.0	-0.8	-1.2	-1.2
Wheeze or whistling in the chest in last year	1.0	1.7	2.5	-1.2	-1.3	-1.6	-1.5	-0.8	-1.5	-1.2
Medication: Allopurinol	1.0	1.3	2.0	-1.0	-0.9	-1.1	-0.7	-1.3	-1.4	-1.4
Medication: Seretide 50 evohaler	1.0	1.2	1.7	-1.1	-1.3	-0.4	-1.2	-0.8	-1.2	-1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.2	-1.5	-0.9	-0.9	-1.2	-1.1	-0.6	-1.1
Loneliness, isolation	1.0	1.4	2.7	-1.6	-1.5	-0.7	-1.3	-0.9	-1.0	-0.9
Ever taken oral contraceptive pill	1.0	1.1	2.5	0.9	0.7	1.4	0.7	1.6	1.2	0.7
Hearing aid user	1.0	1.1	1.9	-0.8	-0.9	-0.8	-1.1	-1.3	-1.4	-1.0
Ever smoked	1.0	1.8	2.8	1.1	1.3	1.4	1.0	1.7	1.6	1.2
Breast Cancer	0.9	2.3	4.6	-1.9	-1.0	-1.4	-1.2	-2.1	-1.4	-1.2
Lupus	0.9	1.3	2.6	-1.6	-1.0	-1.2	-1.0	-1.6	-0.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.0	-0.9	-0.7	-0.8	-0.3	-2.0	-1.1	-0.9
Impedance of arm (right)	0.9	4.1	6.4	-2.1	-2.3	-1.7	-2.5	-1.9	-1.9	-1.6
Loud music exposure frequency	0.9	1.0	2.5	1.6	0.8	1.2	0.5	1.2	0.6	0.6
Headache pain in last month	0.9	1.5	2.3	-1.5	-1.0	-0.9	-1.2	-1.0	-1.5	-1.2
Medication: Ibuprofen	0.9	1.0	1.8	-1.4	-0.9	-1.0	-0.8	-0.5	-1.2	-1.2
Medication: Atorvastatin	0.9	1.1	2.6	0.8	0.9	0.9	1.6	0.7	0.9	1.1
Pack years adult smoking proportion	0.8	1.2	2.2	-0.5	-1.3	-0.6	-1.5	-0.7	-1.2	-1.4
Neuroticism score	0.8	1.8	4.5	-1.7	-1.2	-2.1	-0.9	-1.5	-0.7	-0.1
Weight	0.8	4.0	6.1	2.2	2.1	2.5	2.1	2.4	1.3	1.1
Father’s age at death	0.8	1.0	2.4	0.2	0.9	0.5	1.5	0.1	1.2	1.5
Medication: Amlodipine	0.8	1.2	1.9	1.4	0.3	1.2	0.2	1.3	1.2	1.3
Eye problems/disorders: None of the above	0.8	0.9	1.3	-0.9	-1.0	-0.3	-1.1	-1.1	-0.7	-1.1
Myopia	0.8	1.2	2.0	1.0	0.8	1.0	0.7	1.4	1.3	1.2
Ovarian Cancer	0.7	1.0	1.4	1.0	1.1	0.8	0.9	0.6	1.2	1.1
Coronary Artery Disease (CAD)	0.7	0.8	1.7	0.1	-1.1	-0.2	-1.2	-0.3	-1.1	-1.3
LDL Cholesterol	0.7	1.1	2.7	0.9	1.3	1.0	1.7	0.9	0.7	0.6
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.5	-1.6	-0.9	-1.2	-0.9	-0.7	-1.0	-0.5
Relative age of first facial hair	0.7	1.5	3.5	0.6	1.3	0.6	1.6	0.7	1.3	1.9
Supplements: Zinc	0.7	0.8	2.8	-0.0	-1.2	-0.3	-1.7	-0.2	-0.7	-0.7
Diabetes (mother)	0.7	0.9	1.7	0.8	0.5	1.0	0.4	1.3	1.3	1.1
Impedance of arm (left)	0.7	3.1	4.8	-1.8	-2.0	-1.4	-2.2	-1.6	-1.7	-1.4
Birth weight of first child	0.7	1.3	3.3	1.1	0.8	1.4	0.7	1.8	0.9	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	-0.5	-0.8	-0.7	-0.9	-1.0	-1.0	-1.3
Arm fat-free mass (right)	0.7	3.5	5.7	2.2	1.9	2.4	1.6	2.3	1.4	0.9
Mean time to correctly identify matches	0.7	1.4	4.9	-2.2	-0.1	-1.7	-0.3	-1.2	-0.7	-0.3
Hypertension (Self-reported)	0.7	2.0	2.7	1.5	1.3	1.1	1.6	1.6	1.4	1.4
Medication for cholesterol	0.7	1.1	1.9	-0.3	-0.9	-1.3	-1.4	-1.1	-1.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.7	1.3	0.9	1.6	0.4	1.1	0.3	0.1
Heart disease (siblings)	0.7	0.9	2.2	0.6	1.0	1.5	0.7	1.1	0.7	0.8
Pack years of smoking	0.7	1.1	1.8	-0.5	-1.2	-0.6	-1.3	-0.8	-1.1	-1.4
Leg fat mass (left)	0.7	2.9	4.1	1.6	1.8	1.9	2.0	2.0	1.2	1.2
Fasting Glucose	0.6	0.7	1.4	-0.9	-0.4	-1.2	-0.8	-0.8	-0.8	-0.7
BMI	0.6	3.5	5.6	2.2	1.9	1.9	2.4	1.7	1.4	1.5
Cardiovascular Disease	0.6	2.1	2.8	1.6	1.4	1.1	1.7	1.5	1.4	1.6
Hypothyroidism (self reported)	0.6	1.5	2.5	-1.0	-1.2	-0.6	-1.4	-1.1	-1.6	-1.3
Chronotype (morning person)	0.6	1.4	2.1	-0.9	-1.1	-1.4	-1.3	-1.4	-1.0	-1.0
Diabetes (father)	0.6	0.8	1.8	1.3	0.8	0.8	1.0	0.0	0.9	0.8
Supplements: Glucosamine	0.6	0.8	1.7	0.7	1.3	1.1	0.8	0.9	0.8	0.7
Diabetes (self-reported)	0.6	1.0	2.0	-1.2	-1.3	-0.8	-1.4	-0.6	-0.7	-0.6
Trunk fat-free mass	0.6	3.5	5.6	2.3	2.0	2.4	1.5	2.1	1.4	0.8
Hip circumference	0.6	2.8	3.8	1.8	1.9	1.9	1.9	1.8	1.0	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.5	1.6	0.9	1.1	0.2	1.4	1.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	-1.1	-0.5	-0.5	-0.6	-0.5	-1.3	-1.3
Gout (self-reported)	0.6	0.9	1.4	-0.8	-0.7	-1.2	-0.6	-0.9	-1.1	-1.2
Leg fat mass (right)	0.6	2.3	3.4	1.5	1.6	1.7	1.8	1.8	1.0	0.9
Medication: Aspirin	0.6	0.8	2.1	0.7	1.0	0.7	1.5	0.5	0.8	0.7
Miserableness	0.6	1.1	3.8	-1.9	-0.5	-1.1	-0.4	-0.8	-1.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	0.9	0.7	0.2	0.9	1.5	0.6	0.8
Alcohol drinker status: Never	0.6	0.7	1.9	-1.1	-0.5	-0.6	0.0	-1.4	-0.7	-0.8
Arm predicted mass (left)	0.6	2.8	4.7	1.9	1.9	2.2	1.5	1.9	1.2	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.7	2.9	-1.7	-1.6	-1.2	-1.7	-0.6	-1.2	-0.7
Ulcerative Colitis (UC)	0.5	0.9	2.0	0.4	1.4	1.2	0.7	-0.1	0.9	0.9
Reaction Time	0.5	1.0	3.3	-1.8	-0.2	-1.0	-0.6	-1.1	-0.7	-0.5
Mean Putamen Volume	0.5	0.6	0.9	0.9	0.6	0.7	0.9	0.9	0.3	0.6
Blood Platelet Count	0.5	6.0	10.7	1.9	2.6	3.3	1.6	2.4	2.8	2.2
Body mass index (BMI)	0.5	2.2	4.1	1.4	1.6	1.7	2.0	1.5	0.8	0.9
Trunk fat mass	0.5	1.9	3.2	1.3	1.5	1.6	1.5	1.8	0.8	0.9
Waist circumference	0.5	2.0	3.4	1.5	1.3	1.6	1.6	1.9	0.7	0.7
Past tobacco smoking	0.5	0.9	1.2	-1.0	-1.1	-0.9	-0.5	-1.1	-1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-0.7	-0.1	-0.2	-0.2	-1.2	-1.0	-1.0
Heart attack	0.5	0.6	1.6	-0.8	-0.2	-1.0	0.3	-1.2	-0.9	-0.4
Falls in the last year	0.5	0.7	1.8	-0.4	-1.1	-1.4	-0.7	-0.5	-0.8	-0.4
Medication: Lansoprazole	0.5	0.6	1.4	0.5	1.2	-0.1	0.8	0.3	1.0	1.0
Trunk predicted mass	0.5	2.9	5.0	2.2	1.8	2.2	1.4	1.9	1.2	0.6
Glaucoma (self-reported)	0.5	0.6	1.2	0.8	0.4	1.0	0.7	0.5	0.7	1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	0.6	0.6	1.1	0.5	1.2	0.4	0.2
Arm predicted mass (right)	0.5	2.6	4.3	1.8	1.7	2.1	1.3	2.0	1.2	0.6
Smoking status: Previous	0.5	0.7	1.2	1.0	1.1	0.9	0.3	0.5	0.8	1.1
Long-standing illness, disability or infirmity	0.5	0.7	1.2	-1.0	-1.1	-0.9	-0.8	-0.1	-0.9	-0.7
Friendships satisfaction	0.5	0.7	1.2	0.2	0.9	0.7	0.9	0.2	1.0	1.1
Commuting to job workplace: Walk	0.5	0.5	1.4	0.3	0.9	0.5	1.2	0.5	0.6	0.8
Mineral and other dietary supplements	0.5	0.6	1.7	-0.7	-0.9	-0.9	-0.1	-1.3	-0.5	-0.4
Whole body water mass	0.5	2.7	4.8	2.1	1.7	2.2	1.3	2.0	1.0	0.4
Illnesses of father: High blood pressure	0.5	0.6	1.7	0.4	0.5	1.3	0.1	1.2	0.8	0.6
Basal metabolic rate	0.5	3.0	5.4	2.2	1.7	2.3	1.4	2.1	1.1	0.6
Leg fat percentage (left)	0.5	1.7	3.2	0.6	1.5	1.3	1.8	1.4	0.9	1.1
Arm fat-free mass (left)	0.5	2.7	4.7	1.9	1.8	2.2	1.5	1.9	1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.5	1.7	-0.7	-0.7	-1.3	-0.5	-0.7	-0.5	0.3
Major Depression (MDD)	0.4	0.5	1.1	-0.4	0.5	-0.9	0.9	-1.0	0.3	0.1
Height	0.4	7.2	15.2	3.2	2.5	3.0	1.0	3.9	2.5	1.7
Angina	0.4	0.6	1.0	0.9	0.8	0.9	1.0	0.4	0.7	0.3
Leg fat-free mass (left)	0.4	2.0	4.1	1.9	1.3	2.0	0.9	1.8	0.7	0.2
Average weekly fortified wine intake	0.4	0.4	0.8	0.8	0.8	0.6	0.2	0.9	0.6	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.9	-0.4	-0.0	-1.1	0.6	-0.4	0.1
High blood pressure	0.4	1.0	2.0	1.0	0.9	0.6	1.4	1.1	1.0	1.0
Hayfever, allergic rhinitis or eczema	0.4	1.0	2.1	1.0	1.1	1.4	0.9	0.9	0.7	0.4
Sitting height	0.4	2.8	6.2	2.2	1.2	2.0	0.6	2.5	1.4	0.8
Leg predicted mass (left)	0.4	2.0	4.1	1.9	1.3	2.0	0.9	1.8	0.7	0.2
Nervous feelings	0.4	0.8	1.9	-0.7	0.5	-1.3	0.5	-0.5	0.9	1.4
Mouth/teeth dental problems	0.4	0.7	1.8	-0.6	-1.2	-0.4	-1.3	-0.6	-0.6	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	0.4	0.7	1.2	0.2	0.4	0.9	0.7
Arm fat mass (right)	0.4	1.7	2.7	1.3	1.4	1.6	1.6	1.5	0.6	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.2	1.5	0.1	0.7	0.0	0.7	-0.1	0.0
Whole body fat mass	0.4	1.8	2.9	1.3	1.4	1.6	1.5	1.7	0.8	0.8
Had major operations	0.4	0.5	1.8	0.8	0.4	0.1	0.2	0.5	0.8	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	0.6	0.9	0.5	0.7	0.6	0.6	0.9
Supplements: Vitamin C	0.4	0.4	1.0	-0.4	-0.5	-0.8	-0.7	0.1	-0.7	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	1.1	0.8	-0.2	0.6	0.5	0.6	0.9
Whole body fat-free mass	0.4	2.5	4.5	2.0	1.6	2.1	1.2	1.9	0.9	0.3
Leg fat-free mass (right)	0.4	1.9	3.9	1.9	1.2	2.0	0.8	1.9	0.6	0.1
Arm fat mass (left)	0.4	1.5	2.5	1.2	1.4	1.5	1.6	1.3	0.5	0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.1	0.1	-0.8	-0.6	-0.8	-0.3	-1.1	-0.9
Age started oral contraceptive pill	0.4	0.5	1.2	-0.8	-0.1	-1.1	0.3	-0.6	-0.6	-0.8
Impedance of whole body	0.4	1.9	3.6	-1.7	-1.6	-1.2	-1.9	-1.1	-1.0	-0.8
Age at First Birth	0.3	0.4	1.3	-1.1	-0.3	-0.7	0.1	-0.4	-0.7	-0.6
HDL Cholesterol	0.3	0.6	1.1	-0.7	-0.9	-0.8	-1.1	-0.6	-0.6	-0.6
Rheumatoid Arthritis	0.3	0.4	0.6	0.7	-0.8	-0.2	-0.8	-0.2	-0.5	-0.7
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	0.1	0.2	1.1	0.5	0.2	0.4	0.5
Blood White Count	0.3	2.4	4.5	1.6	1.8	2.1	1.6	1.4	1.2	0.8
Allergy or Eczema	0.3	0.7	1.6	0.2	1.2	1.1	1.1	0.5	0.8	0.4
Hearing difficulty/problems: Yes	0.3	0.4	0.7	-0.4	-0.5	-0.7	-0.8	-0.2	-0.7	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.6	-0.4	-0.7	-0.5	-0.6	-0.5	-0.6	-0.8
Medication: Metformin	0.3	0.4	1.4	-0.9	-0.7	-0.6	-1.2	0.0	-0.2	-0.2
Alcohol usually taken with meals	0.3	0.5	1.1	0.8	0.4	0.8	0.4	0.1	1.1	1.0
Alcohol intake versus 10 years previously	0.3	0.5	1.2	0.1	-0.7	0.3	-1.1	0.4	-0.8	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	-1.0	0.6	-0.8	1.0	-0.4	0.2	0.2
Standing height	0.3	2.6	5.2	2.0	1.4	2.2	0.5	2.3	1.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.0	-1.0	-0.8	-0.5	-0.5	-0.8	-0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.4	-0.5	-0.6	0.2	-0.6	-0.6	-1.2	-0.9
High blood pressure (siblings)	0.3	0.4	0.6	0.5	0.6	0.4	0.6	0.6	0.8	0.7
Leg fat percentage (right)	0.3	1.2	2.7	0.5	1.3	1.1	1.7	1.1	0.7	0.8
Exposure to tobacco smoke outside home	0.3	0.4	1.5	-1.2	-0.6	-1.0	0.4	-0.2	-0.2	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.8	0.8	0.1	0.6	-0.0	0.7	0.7
Age at first live birth	0.3	0.5	1.3	0.7	-0.5	0.9	-0.7	1.1	0.5	0.2
Health satisfaction	0.3	0.4	1.1	-0.3	1.1	0.0	0.6	0.5	0.7	0.7
Angina (self-reported)	0.3	0.4	1.0	0.6	0.7	0.6	1.0	0.2	0.5	0.2
Migraine (self-reported)	0.3	0.4	1.3	0.6	0.6	1.2	0.9	0.2	0.3	-0.0
Medication: Omeprazole	0.3	0.4	1.0	-0.6	-0.5	-1.0	-0.2	-0.7	-0.2	0.7
Age at last live birth	0.3	0.4	1.0	1.0	-0.2	0.5	-0.8	0.8	0.1	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.5	0.2	0.6	-0.1	1.2	-0.4	0.4	0.4
Diabetes diagnosed by doctor	0.3	0.5	1.4	-0.9	-1.0	-0.3	-1.2	-0.2	-0.4	-0.4
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.3	0.5	-0.1	0.8	0.7	0.5	0.7
Leg predicted mass (right)	0.3	1.8	3.8	1.9	1.1	1.9	0.7	1.8	0.5	0.1
Mother’s age at death	0.3	0.4	0.7	0.7	0.8	0.6	0.6	0.5	0.6	0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	-1.0	-0.8	-0.2	-0.9	-0.6	0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.0	-0.4	0.1	-0.7	0.7	-1.0	-0.5	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.7	0.1	-0.8	0.3	-0.9	-0.3	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.5	0.7	-0.2	0.6	-0.1	0.1	0.5
Crohns Disease (2017)	0.2	0.4	1.0	-0.8	-0.4	-0.4	-0.3	-1.0	-0.4	-0.5
Prostate Cancer	0.2	0.3	1.4	-0.1	0.4	-0.3	0.1	-1.2	0.3	0.7
Triglycerides	0.2	0.3	0.6	0.7	0.6	0.4	0.8	0.4	0.0	-0.1
Ulcerative Colitis	0.2	0.4	0.8	-0.4	0.1	0.2	-0.9	-0.8	-0.6	-0.6
Heel T-Score	0.2	1.7	2.4	-1.6	-1.3	-1.3	-1.1	-1.1	-1.3	-1.2
Systolic Blood Pressure	0.2	0.8	2.1	1.4	0.7	0.8	0.6	0.7	0.9	0.9
Number of treatments/medications taken	0.2	0.4	0.8	-0.8	-0.7	-0.9	-0.2	-0.6	-0.7	-0.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.3	-0.7	0.2	-0.3	0.2	-0.6	-0.7
Vitamin and mineral supplements	0.2	0.2	0.5	0.1	-0.7	-0.2	-0.7	-0.6	-0.3	0.1
Trunk fat percentage	0.2	0.8	1.5	0.8	1.0	1.2	1.0	1.2	0.3	0.6
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	-0.0	-0.3	-0.0	-0.2	-0.8	-0.5
Financial difficulties in last 2 years	0.2	0.2	0.5	-0.6	-0.2	0.1	0.1	0.6	-0.5	-0.7
Happiness	0.2	0.2	0.5	0.3	0.7	0.5	0.3	0.3	0.5	0.4
Noisy workplace	0.2	0.3	1.3	1.1	0.1	0.7	-0.2	0.3	-0.3	-0.3
Birth weight	0.2	0.3	1.0	-1.0	-0.6	0.0	-0.5	-0.6	-0.5	-0.5
Body fat percentage	0.2	0.9	1.6	0.7	1.1	1.1	1.2	1.2	0.5	0.7
Qualifications: College or University degree	0.2	0.6	1.8	-0.1	-1.3	-0.7	-1.4	-0.2	-0.3	-0.5
Neck or shoulder pain in last month	0.2	0.2	0.6	-0.1	-0.6	-0.2	-0.2	0.1	-0.7	-0.8
Medication: Blood pressure	0.2	0.4	0.8	0.8	0.3	0.6	0.1	0.9	0.7	0.8
Suffer from ‘nerves’	0.2	0.3	1.4	-0.5	-0.3	-1.2	-0.3	-0.4	-0.2	0.4
Overall health rating	0.2	0.3	0.9	-0.4	0.6	-0.3	0.6	0.1	0.6	0.9
Knee pain experienced in last month	0.2	0.3	0.7	0.5	0.3	0.5	0.7	0.8	-0.4	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.4	0.2	0.3	0.1	0.1	0.6	0.8
Ever had bowel cancer screening	0.2	0.3	1.0	-0.8	-0.3	-1.0	0.2	-0.2	-0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.3	0.4	0.3	0.9	0.6	0.3	0.3
Wears glasses or contact lenses	0.2	0.2	0.7	0.1	0.6	-0.1	0.8	0.6	0.1	0.4
Financial situation satisfaction	0.2	0.3	0.5	-0.6	0.2	0.1	0.6	0.7	0.6	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.6	0.0	0.3	0.2	0.1	0.3	0.8
High cholesterol (Self-reported)	0.2	0.4	1.5	0.6	0.7	0.3	1.2	0.6	0.3	0.4
Medication: Paracetamol	0.2	0.3	0.8	0.1	0.4	-0.1	0.9	0.5	0.4	0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.4	0.7	1.2	0.2	1.1	0.5	0.8	0.6
Commuting to job workplace: Cycle	0.2	0.2	0.8	0.4	0.6	-0.0	0.9	0.3	-0.2	-0.3
Cholesterol lowering medication	0.2	0.3	1.0	-0.4	-0.0	1.0	0.6	0.6	0.4	0.3
Pain experienced in last month	0.2	0.3	0.9	-0.2	-0.3	-1.0	-0.2	-0.8	0.2	-0.1
Supplements: Calcium	0.2	0.3	1.3	-0.2	-0.4	-1.1	-0.3	0.0	-0.4	0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.4	0.2	-0.2	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.2	0.7	0.6	0.4	-0.7	0.5	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.1	0.1	-0.2	0.1	-0.7	-0.6	-0.7
Waist Hip Ratio (WHR)	0.1	0.6	2.2	1.0	-0.0	0.7	0.2	1.5	0.6	0.3
Smoking Status	0.1	0.3	0.6	0.5	0.3	0.5	0.1	0.7	0.8	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.5	-0.6	-0.2	-0.7	0.2	0.0	-0.2
Hand grip strength (left)	0.1	0.2	0.7	0.4	0.8	0.5	0.0	0.3	0.4	-0.1
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.3	-0.5	-0.8	-0.3	-0.4	0.5	0.6
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.1	0.6	-0.3	0.7	-0.1	0.3	0.3
Medication: Co-codamol	0.1	0.2	0.6	0.1	-0.3	-0.7	0.1	-0.5	-0.3	-0.3
Impedance of leg (right)	0.1	0.6	1.7	-1.3	-0.9	-0.7	-1.0	-0.6	-0.1	-0.1
Hand grip strength (right)	0.1	0.3	0.8	0.8	0.5	0.9	-0.2	-0.0	-0.0	-0.4
Current tobacco smoking	0.1	0.2	0.6	-0.8	-0.7	-0.3	-0.1	0.2	-0.3	-0.6
Maternal smoking around birth	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.5	0.1	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	0.1	-0.4	0.3	-0.7	-0.1	-0.8	-0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.7	-0.1	0.2	-0.3	0.0	-0.8	-0.2	-0.0
Impedance of leg (left)	0.1	0.5	1.3	-1.1	-0.7	-0.6	-0.9	-0.2	-0.0	0.2
Number of incorrect matches in round	0.1	0.2	0.4	0.5	0.6	0.3	0.6	-0.0	-0.0	0.3
Had menopause	0.1	0.1	0.7	-0.9	-0.1	-0.3	-0.1	0.0	0.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.1	-0.3	-0.4	-0.7	-0.2	-0.7	-0.4
Qualifications: None of the above	0.1	0.2	0.6	-0.2	0.2	0.7	0.8	-0.3	-0.1	0.2
Allergy	0.1	0.1	0.3	0.3	0.1	-0.6	0.5	0.2	0.3	0.4
Medication: Ramipril	0.1	0.1	0.3	-0.3	-0.5	-0.2	0.0	-0.3	-0.5	-0.6
Medication: Simvastatin	0.1	0.2	0.5	0.4	0.4	0.4	0.4	0.7	0.6	0.3
Fluid intelligence score	0.1	0.1	0.5	-0.3	-0.7	0.1	-0.3	0.1	-0.4	-0.0
Arm fat percentage (right)	0.1	0.4	0.9	0.4	0.7	0.7	1.0	0.7	-0.1	0.2
Time employed in main current job	0.1	0.1	0.2	0.4	-0.3	0.2	-0.4	0.0	-0.1	-0.0
Medication: Cholesterol lowering	0.1	0.2	0.7	0.8	0.6	0.0	0.6	0.3	0.3	0.3
Prospective memory result	0.1	0.1	0.2	0.2	0.2	-0.4	0.3	0.5	0.2	-0.3
Lung cancer (father)	0.1	0.1	0.7	-0.8	-0.3	-0.2	-0.1	-0.3	-0.2	-0.1
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.0	0.2	0.4	0.3	0.3	0.6	0.4
Breastfed as a baby	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.3	0.0	0.0	0.1
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	-0.3	0.4	-0.2	0.2	0.9	0.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.3	0.8	0.1	0.3	0.3	0.6	0.3
Medication: Paracetamol	0.1	0.1	0.3	0.2	0.2	0.1	0.5	0.5	0.0	0.1
Worry too long after embarrassment	0.1	0.2	0.5	0.4	0.1	0.1	-0.1	0.6	0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.5	-0.6	-0.3	-0.2	-0.1	-0.3	0.2
Pulse wave peak to peak time	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.3	-0.2	-0.5	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.6	0.2	0.2	0.1	-0.2	0.8	0.2	0.2
Pulse rate, automated reading	0.1	0.3	1.1	-0.2	-0.7	-0.3	-1.1	0.2	-0.1	-0.2
Comparative height size at age 10	0.1	0.4	1.3	0.4	-0.2	0.7	-0.4	0.1	-0.7	-1.1
Illnesses of father: Heart disease	0.1	0.1	0.4	0.4	0.3	0.7	0.3	0.3	0.3	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.2	0.0	0.4	-0.5	0.7	0.5	0.0
Arm fat percentage (left)	0.1	0.4	1.1	0.4	0.8	0.8	1.1	0.7	-0.1	0.2
Qualifications: nursing, teaching	0.1	0.1	0.4	0.6	-0.0	0.3	-0.4	-0.1	0.1	0.1
Back pain experienced in last month	0.1	0.1	0.4	-0.0	-0.1	0.1	0.6	-0.3	-0.4	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.6	0.8	-0.0	0.0	0.2	0.4	0.0	0.1
Osteoarthritis (self-reported)	0.1	0.2	0.6	-0.2	-0.8	-0.6	-0.3	-0.2	-0.2	0.2
Medication: Gliclazide	0.1	0.1	0.4	0.2	-0.5	0.4	-0.6	0.4	-0.2	0.0
Smoking status: Current	0.1	0.1	0.5	-0.3	-0.3	0.1	0.0	0.7	0.0	-0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.4	-0.3	0.2	0.1	0.3	-0.1	0.2	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.4	-0.3	-0.5	-0.1	-0.3	0.1	0.5
Commuting to job workplace: Public transport	0.1	0.1	0.4	0.6	-0.2	-0.1	0.2	0.3	-0.0	0.2
Number of operations (self-reported)	0.1	0.1	0.4	0.4	0.1	-0.0	0.6	0.5	0.1	0.2
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.4	0.6	0.0	0.5	-0.2	0.1	0.2
Risk taking	0.1	0.1	0.5	-0.5	0.2	0.1	-0.2	-0.7	-0.2	0.0
Unable to work because of sickness or disability	0.1	0.2	1.0	0.1	0.2	0.2	0.3	1.0	0.1	0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.8	-0.2	-0.3	0.0	-0.9	-0.2	-0.2	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	0.5	-0.1	0.1	-0.4	0.4	-0.4	-0.2
Blood Eosinophil Count	0.0	0.4	0.6	-0.5	-0.7	-0.1	-0.8	0.3	-0.7	-0.8
Blood Red Count	0.0	0.5	1.3	1.1	0.7	1.0	-0.1	0.5	0.4	0.3
Hair Pigment	0.0	0.2	0.9	0.6	0.1	0.5	-0.0	1.0	0.2	0.3
Tanning	0.0	0.3	0.8	0.3	0.2	0.5	0.0	0.9	0.8	0.5
Age when periods started (menarche)	0.0	0.1	0.2	0.2	0.4	0.2	-0.2	-0.4	-0.2	-0.0
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	-0.0	0.2	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	0.1	-0.0	-0.0	0.0	-0.2	-0.2
Stomach or abdominal pain in last month	0.0	0.1	0.2	-0.0	-0.0	-0.3	0.4	-0.0	0.1	0.3
Medication: Levothyroxine sodium	0.0	0.1	0.2	-0.0	-0.1	0.4	-0.2	0.2	-0.4	-0.1
Hearing difficulty/problems with background noise	0.0	0.1	0.1	-0.2	-0.0	-0.2	-0.2	0.3	0.3	0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.1	0.2	-0.0	0.4	0.0	0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.3	0.2	0.3	-0.3	0.0	-0.5	0.1	-0.0
Illnesses of father: None of the above (group 1)	0.0	0.0	0.2	0.1	-0.4	0.2	-0.2	0.3	0.1	0.1

Hub : Genes

GSTCD

Models

Trait associations