[Hub]/) : Traits : HDL Cholesterol :

chr11:46,010,847-48,783,497

Best TWAS P=1.04e-20 · Best GWAS P=1.49e-16 conditioned to 0.222

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AGBL2 0.03 0.02 enet 7 0.03 7.9e-05 7.05 7.2 4.8e-13 0.40 0.38 0.57 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM180B 0.07 0.08 lasso 3 0.08 9.1e-10 -6.10 -6.0 2.6e-09 -0.24 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex PTPRJ 0.06 0.04 lasso 4 0.05 7.6e-07 7.43 6.9 5.4e-12 0.37 0.02 0.98 FALSE
4 GTEx Adipose Subcutaneous ACP2 0.08 0.03 enet 18 0.03 3.5e-03 7.20 -7.2 5.5e-13 -0.49 0.14 0.63 FALSE
5 GTEx Adipose Subcutaneous C1QTNF4 0.16 0.22 lasso 4 0.22 2.5e-18 -6.30 6.1 1.2e-09 0.24 1.00 0.00 FALSE
6 GTEx Adipose Visceral Omentum ACP2 0.08 0.05 lasso 5 0.05 1.4e-03 7.83 -8.0 1.0e-15 -0.64 0.13 0.69 FALSE
7 GTEx Artery Aorta C1QTNF4 0.09 0.10 lasso 1 0.08 3.2e-05 -6.10 6.1 1.0e-09 0.27 0.56 0.10 FALSE
8 GTEx Brain Cerebellar Hemisphere MADD 0.44 0.14 lasso 7 0.21 4.0e-06 7.20 -7.1 1.3e-12 -0.51 0.12 0.72 FALSE
9 GTEx Brain Cerebellar Hemisphere ACP2 0.29 0.05 enet 16 0.12 5.9e-04 8.03 -9.3 1.0e-20 -0.84 0.03 0.64 TRUE
10 GTEx Brain Cerebellum MADD 0.21 0.00 enet 13 0.11 3.3e-04 7.83 -8.0 8.9e-16 -0.56 0.10 0.56 FALSE
11 GTEx Brain Cortex MTCH2 0.21 0.19 lasso 6 0.16 4.0e-05 -6.23 -6.9 3.7e-12 -0.26 0.42 0.04 FALSE
12 GTEx Brain Hypothalamus NR1H3 0.25 0.18 lasso 5 0.10 2.7e-03 7.99 7.8 4.2e-15 0.51 0.07 0.54 FALSE
13 GTEx Brain Putamen basal ganglia CKAP5 0.25 0.07 lasso 3 0.14 4.4e-04 7.53 8.0 1.8e-15 0.59 0.05 0.29 FALSE
14 GTEx Breast Mammary Tissue C1QTNF4 0.10 0.06 lasso 2 0.03 8.5e-03 -5.29 5.3 9.5e-08 0.19 0.29 0.10 FALSE
15 GTEx Breast Mammary Tissue CKAP5 0.09 0.05 enet 16 0.03 1.3e-02 4.36 5.4 5.7e-08 0.69 0.51 0.23 FALSE
16 GTEx Breast Mammary Tissue (Female) ACP2 0.03 0.00 lasso 1 0.02 1.0e-01 7.59 -7.5 7.3e-14 -0.49 0.03 0.09 FALSE
17 GTEx Breast Mammary Tissue (Female) PSMC3 0.02 0.01 lasso 1 0.04 2.5e-02 6.41 -6.4 1.5e-10 -0.35 0.03 0.08 FALSE
18 GTEx Cells EBV-transformed lymphocytes ACP2 0.17 0.03 lasso 6 0.03 4.2e-02 7.91 -7.4 1.7e-13 -0.60 0.08 0.78 FALSE
19 GTEx Cells Transformed fibroblasts MADD 0.19 0.00 enet 17 0.09 3.3e-07 7.35 -5.2 2.4e-07 -0.36 0.07 0.87 FALSE
20 GTEx Cells Transformed fibroblasts PSMC3 0.07 0.00 enet 13 0.02 2.3e-02 6.41 -7.1 9.6e-13 -0.34 0.10 0.19 FALSE
21 GTEx Cells Transformed fibroblasts C1QTNF4 0.13 0.11 enet 19 0.12 5.2e-09 -6.25 7.2 7.7e-13 0.30 1.00 0.00 FALSE
22 GTEx Cells Transformed fibroblasts NDUFS3 0.08 0.01 lasso 2 0.01 3.3e-02 -6.30 5.9 4.0e-09 0.23 0.21 0.05 FALSE
23 GTEx Colon Transverse C1QTNF4 0.07 0.02 lasso 6 0.03 2.0e-02 -6.30 6.4 1.4e-10 0.25 0.28 0.10 FALSE
24 GTEx Esophagus Gastroesophageal Junction CKAP5 0.11 0.04 lasso 3 0.03 2.1e-02 4.31 6.0 1.5e-09 0.53 0.20 0.36 FALSE
25 GTEx Esophagus Mucosa ACP2 0.07 0.04 enet 11 0.04 6.2e-04 7.67 -8.4 4.5e-17 -0.68 0.07 0.91 FALSE
26 GTEx Esophagus Mucosa C11orf49 0.19 0.05 enet 21 0.12 3.2e-08 8.16 7.3 2.1e-13 0.75 0.03 0.96 FALSE
27 GTEx Esophagus Mucosa C1QTNF4 0.10 0.11 lasso 1 0.10 5.0e-07 -6.10 6.1 1.0e-09 0.27 0.94 0.01 FALSE
28 GTEx Heart Atrial Appendage ACP2 0.10 0.12 enet 7 0.10 2.7e-05 6.95 -7.9 2.4e-15 -0.54 0.17 0.52 FALSE
29 GTEx Heart Atrial Appendage C1QTNF4 0.26 0.14 lasso 9 0.17 3.9e-08 -6.10 5.4 7.8e-08 0.20 0.97 0.00 FALSE
30 GTEx Heart Left Ventricle MADD 0.14 0.01 enet 17 0.05 7.0e-04 8.09 -7.8 8.2e-15 -0.57 0.07 0.85 FALSE
31 GTEx Heart Left Ventricle ACP2 0.11 0.06 enet 18 0.10 9.2e-06 8.09 -8.9 4.3e-19 -0.77 0.06 0.93 FALSE
32 GTEx Heart Left Ventricle C1QTNF4 0.10 0.11 lasso 1 0.09 1.1e-05 -6.10 6.1 1.0e-09 0.27 0.34 0.03 FALSE
33 GTEx Heart Left Ventricle ARHGAP1 0.06 0.03 lasso 2 0.02 2.1e-02 8.26 -7.4 1.2e-13 -0.96 0.02 0.90 FALSE
34 GTEx Lung ACP2 0.04 0.03 lasso 2 0.04 4.3e-04 7.43 -8.5 2.1e-17 -0.64 0.09 0.84 FALSE
35 GTEx Lung C1QTNF4 0.18 0.15 lasso 6 0.13 3.2e-10 -5.18 5.9 4.2e-09 0.22 1.00 0.00 FALSE
36 GTEx Muscle Skeletal MTCH2 0.05 0.03 enet 15 0.04 1.5e-04 -6.06 -7.9 3.3e-15 -0.37 0.52 0.39 FALSE
37 GTEx Muscle Skeletal C1QTNF4 0.09 0.14 lasso 3 0.13 9.9e-13 -6.10 6.3 2.3e-10 0.26 1.00 0.00 FALSE
38 GTEx Nerve Tibial NR1H3 0.10 0.00 enet 24 0.08 4.7e-06 0.18 5.3 1.0e-07 0.23 0.06 0.30 FALSE
39 GTEx Nerve Tibial LRP4 0.28 0.24 enet 24 0.30 3.5e-21 -4.89 6.9 6.2e-12 0.61 1.00 0.00 FALSE
40 GTEx Nerve Tibial PTPRJ 0.05 0.03 enet 13 0.03 2.7e-03 3.42 5.3 9.2e-08 0.24 0.19 0.11 FALSE
41 GTEx Nerve Tibial C11orf49 0.17 0.01 enet 21 0.05 9.5e-05 7.88 8.4 4.2e-17 0.70 0.08 0.81 FALSE
42 GTEx Nerve Tibial SLC39A13 0.07 0.01 enet 14 0.02 7.6e-03 -5.23 -7.3 2.2e-13 -0.36 0.13 0.34 FALSE
43 GTEx Nerve Tibial C1QTNF4 0.20 0.23 enet 12 0.23 1.7e-16 -6.10 7.0 2.4e-12 0.34 1.00 0.00 FALSE
44 GTEx Nerve Tibial LRP4-AS1 0.23 0.16 enet 15 0.24 1.1e-16 -4.89 5.8 7.4e-09 0.53 1.00 0.00 FALSE
45 GTEx Pancreas LRP4 0.11 0.10 enet 16 0.14 1.8e-06 4.31 -5.7 1.4e-08 -0.63 0.66 0.29 FALSE
46 GTEx Skin Not Sun Exposed Suprapubic LRP4 0.13 0.00 lasso 7 0.02 3.5e-02 4.33 5.3 1.3e-07 0.34 0.11 0.23 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic DDB2 0.07 0.02 enet 13 0.04 3.5e-03 7.43 6.0 1.7e-09 0.59 0.11 0.29 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic SLC39A13 0.07 0.11 lasso 2 0.10 5.2e-06 7.03 7.1 1.4e-12 0.54 0.14 0.63 FALSE
49 GTEx Skin Sun Exposed Lower leg PTPMT1 0.13 0.01 enet 33 0.03 3.0e-03 7.67 5.5 2.9e-08 0.32 0.03 0.83 FALSE
50 GTEx Skin Sun Exposed Lower leg ACP2 0.16 0.14 enet 15 0.15 1.8e-12 7.59 -7.7 9.5e-15 -0.52 0.19 0.81 FALSE
51 GTEx Skin Sun Exposed Lower leg PSMC3 0.20 0.05 lasso 7 0.10 1.2e-08 6.41 -5.1 2.7e-07 -0.19 0.96 0.00 FALSE
52 GTEx Spleen ACP2 0.19 -0.01 lasso 5 0.04 4.1e-02 8.20 -6.6 4.4e-11 -0.81 0.04 0.64 FALSE
53 GTEx Testis NR1H3 0.10 0.10 lasso 6 0.08 2.9e-04 8.07 -8.0 1.2e-15 -0.56 0.08 0.86 FALSE
54 GTEx Testis MTCH2 0.17 0.16 lasso 3 0.16 1.0e-07 -5.29 -5.3 1.1e-07 -0.19 1.00 0.00 FALSE
55 GTEx Thyroid ACP2 0.19 0.14 lasso 4 0.12 3.0e-09 7.83 -8.1 4.4e-16 -0.64 0.23 0.77 FALSE
56 GTEx Whole Blood C1QTNF4 0.09 0.05 lasso 3 0.03 1.4e-03 -6.28 6.3 3.0e-10 0.22 0.62 0.04 FALSE
57 METSIM Adipose ACP2 0.05 0.04 blup 302 0.06 1.7e-09 -5.25 -7.8 5.5e-15 -0.50 0.39 0.61 FALSE
58 METSIM Adipose ARHGAP1 0.08 0.02 enet 23 0.06 3.6e-09 3.96 -5.3 9.6e-08 -0.63 0.06 0.94 FALSE
59 METSIM Adipose C1QTNF4 0.24 0.31 lasso 7 0.31 1.2e-46 -6.22 6.5 7.7e-11 0.23 1.00 0.00 FALSE
60 METSIM Adipose MYBPC3 0.11 0.10 enet 26 0.11 1.0e-15 -5.25 5.8 8.7e-09 0.27 1.00 0.00 FALSE
61 METSIM Adipose PSMC3 0.06 0.03 enet 28 0.04 2.3e-06 -4.73 -6.4 2.1e-10 -0.23 0.89 0.03 FALSE
62 NTR Blood ACP2 0.01 0.00 enet 7 0.01 2.5e-03 7.67 -8.4 6.6e-17 -0.66 0.07 0.85 FALSE
63 NTR Blood DDB2 0.01 0.00 lasso 7 0.01 2.2e-03 8.20 -8.7 3.4e-18 -0.91 0.03 0.89 FALSE
64 NTR Blood MTCH2 0.02 0.04 lasso 1 0.04 1.3e-11 -6.24 6.2 4.4e-10 0.22 1.00 0.00 FALSE
65 NTR Blood PTPRJ 0.04 0.01 blup 285 0.02 8.5e-08 6.39 5.7 1.1e-08 0.35 0.13 0.87 FALSE
66 ROSMAP Brain Pre-frontal Cortex NR1H3 0.06 0.01 blup 302 0.04 1.5e-05 7.67 6.4 1.4e-10 0.51 0.18 0.79 FALSE
67 ROSMAP Brain Pre-frontal Cortex MTCH2 0.35 0.40 enet 9 0.40 4.7e-56 -6.22 -6.2 5.0e-10 -0.22 1.00 0.00 FALSE
68 ROSMAP Brain Pre-frontal Cortex PTPMT1 0.03 0.02 blup 270 0.02 3.8e-04 7.03 7.6 4.0e-14 0.57 0.14 0.78 FALSE
69 ROSMAP Brain Pre-frontal Cortex LRP4 0.04 0.06 blup 286 0.05 3.5e-07 8.01 7.7 9.7e-15 0.87 0.07 0.93 FALSE
70 ROSMAP Brain Pre-frontal Cortex ACP2 0.03 0.00 blup 295 0.02 1.5e-03 -5.20 -8.9 6.9e-19 -0.64 0.14 0.67 FALSE
71 ROSMAP Brain Pre-frontal Cortex C11orf49 0.02 0.02 blup 322 0.02 3.3e-04 4.87 6.9 5.2e-12 0.76 0.50 0.46 FALSE
72 ROSMAP Brain Pre-frontal Cortex CELF1 0.03 0.01 bslmm 289 0.01 2.9e-02 4.74 5.9 2.8e-09 0.31 0.18 0.06 FALSE
73 ROSMAP Brain Pre-frontal Cortex C1QTNF4 0.05 0.06 blup 281 0.06 1.7e-08 -5.28 7.6 3.7e-14 0.39 1.00 0.00 FALSE
74 ROSMAP Brain Pre-frontal Cortex ZNF408 0.04 0.02 blup 243 0.03 5.0e-05 4.65 -5.7 1.2e-08 -0.80 0.06 0.93 FALSE
75 YFS Blood DDB2 0.02 0.00 bslmm 306 0.01 1.9e-04 7.37 -5.6 1.7e-08 -0.48 0.05 0.79 FALSE
76 YFS Blood NR1H3 0.34 0.15 enet 66 0.24 3.1e-76 7.95 -7.2 8.0e-13 -0.43 0.13 0.87 FALSE
77 YFS Blood NUP160 0.02 0.01 blup 290 0.01 1.7e-04 -6.19 -7.6 2.2e-14 -0.36 0.45 0.27 FALSE
78 YFS Blood PSMC3 0.02 0.01 blup 289 0.01 2.8e-05 -6.30 -6.5 1.0e-10 -0.36 0.53 0.23 FALSE
79 The Cancer Genome Atlas Bladder Urothelial Carcinoma C1QTNF4 0.06 0.07 lasso 2 0.06 4.9e-06 -6.23 6.4 2.1e-10 0.24 0.30 0.66 FALSE
80 The Cancer Genome Atlas Breast Invasive Carcinoma ACP2 0.02 0.01 blup 44 0.02 2.7e-04 7.83 -7.7 9.4e-15 -0.47 0.02 0.51 FALSE
81 The Cancer Genome Atlas Breast Invasive Carcinoma C11orf49 0.05 0.00 blup 90 0.02 3.0e-04 7.91 6.6 5.4e-11 0.70 0.01 0.96 FALSE
82 The Cancer Genome Atlas Breast Invasive Carcinoma C1QTNF4 0.02 0.01 lasso 5 0.02 2.1e-04 6.92 7.9 2.4e-15 0.48 0.00 0.94 FALSE
83 The Cancer Genome Atlas Breast Invasive Carcinoma MADD 0.11 0.03 enet 14 0.06 1.4e-11 -0.39 -5.2 2.0e-07 -0.36 0.86 0.07 FALSE
84 The Cancer Genome Atlas Breast Invasive Carcinoma NUP160 0.03 0.01 blup 44 0.01 1.9e-03 -5.97 -7.5 6.7e-14 -0.26 0.02 0.05 TRUE
85 The Cancer Genome Atlas Colon Adenocarcinoma C1QTNF4 0.12 0.12 lasso 1 0.12 1.6e-07 -6.10 6.1 1.0e-09 0.27 0.38 0.56 FALSE
86 The Cancer Genome Atlas Colon Adenocarcinoma KBTBD4 0.14 0.01 blup 13 0.02 1.6e-02 1.19 -6.4 1.9e-10 -0.26 0.01 0.06 FALSE
87 The Cancer Genome Atlas Esophageal Carcinoma C1QTNF4 0.39 0.33 blup 15 0.35 6.1e-12 -6.10 6.1 9.0e-10 0.25 0.36 0.64 FALSE
88 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ACP2 0.02 0.03 lasso 1 0.02 1.5e-03 7.83 -7.8 5.0e-15 -0.64 0.02 0.72 FALSE
89 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1QTNF4 0.06 0.08 lasso 3 0.08 7.5e-09 -6.22 6.2 4.7e-10 0.21 0.31 0.69 FALSE
90 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FNBP4 0.10 0.03 blup 45 0.05 7.7e-06 -6.23 -6.6 4.0e-11 -0.20 0.37 0.08 FALSE
91 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MYBPC3 0.05 0.03 blup 43 0.04 6.0e-05 -5.09 5.3 1.2e-07 0.22 0.73 0.11 FALSE
92 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NUP160 0.08 0.03 blup 42 0.04 6.7e-05 -6.24 -7.0 2.8e-12 -0.28 0.24 0.11 FALSE
93 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ACP2 0.03 0.03 blup 44 0.04 3.5e-05 8.07 -8.4 3.9e-17 -0.64 0.03 0.96 FALSE
94 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C1QTNF4 0.12 0.14 enet 4 0.16 6.5e-18 -6.22 6.3 2.2e-10 0.24 0.28 0.72 FALSE
95 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PSMC3 0.05 0.04 lasso 3 0.05 3.8e-06 -4.73 -5.2 1.7e-07 -0.22 0.84 0.03 FALSE
96 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C1QTNF4 0.13 0.16 lasso 1 0.16 3.1e-09 -6.22 6.2 5.0e-10 0.22 0.28 0.72 FALSE
97 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma NUP160 0.13 0.05 lasso 4 0.04 2.6e-03 6.50 -6.5 7.8e-11 -0.35 0.09 0.06 FALSE
98 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PSMC3 0.07 0.07 enet 7 0.06 1.4e-04 -5.19 -5.2 1.6e-07 -0.19 0.39 0.03 FALSE
99 The Cancer Genome Atlas Brain Lower Grade Glioma ACP2 0.09 0.04 enet 12 0.06 5.0e-07 7.20 -7.9 2.0e-15 -0.45 0.05 0.95 FALSE
100 The Cancer Genome Atlas Brain Lower Grade Glioma MADD 0.08 0.01 lasso 5 0.05 3.1e-06 -5.20 -5.9 3.4e-09 -0.42 0.05 0.54 FALSE
101 The Cancer Genome Atlas Brain Lower Grade Glioma MTCH2 0.11 0.11 lasso 2 0.10 6.4e-12 -6.22 -6.2 4.9e-10 -0.21 0.82 0.18 FALSE
102 The Cancer Genome Atlas Brain Lower Grade Glioma PSMC3 0.10 0.05 blup 39 0.08 3.7e-09 -5.31 -5.2 2.6e-07 -0.22 0.36 0.63 FALSE
103 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C1QTNF4 0.19 0.19 lasso 3 0.19 3.2e-09 -6.22 6.2 5.0e-10 0.21 0.32 0.68 FALSE
104 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PSMC3 0.09 0.07 blup 39 0.06 8.7e-04 -5.20 -6.6 3.4e-11 -0.31 0.42 0.30 FALSE
105 The Cancer Genome Atlas Lung Adenocarcinoma C1QTNF4 0.03 0.02 blup 15 0.02 1.3e-03 -6.10 6.2 4.8e-10 0.27 0.10 0.26 FALSE
106 The Cancer Genome Atlas Lung Adenocarcinoma MYBPC3 0.04 0.02 enet 10 0.04 2.9e-05 -5.18 6.1 1.0e-09 0.32 0.15 0.49 FALSE
107 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DDB2 0.02 0.03 lasso 1 0.02 1.0e-03 7.95 8.0 1.8e-15 0.52 0.03 0.82 FALSE
108 The Cancer Genome Atlas Prostate Adenocarcinoma ARHGAP1 0.05 0.04 blup 26 0.05 1.1e-05 3.64 -5.6 2.5e-08 -0.82 0.01 0.98 FALSE
109 The Cancer Genome Atlas Prostate Adenocarcinoma NUP160 0.03 0.02 enet 7 0.02 6.3e-03 -6.06 -5.2 1.8e-07 -0.12 0.10 0.03 FALSE
110 The Cancer Genome Atlas Prostate Adenocarcinoma PSMC3 0.02 0.02 blup 39 0.02 5.7e-03 -5.31 -7.1 1.5e-12 -0.34 0.02 0.26 FALSE
111 The Cancer Genome Atlas Soft Tissue Sarcoma ACP2 0.08 0.06 enet 7 0.06 1.6e-04 4.97 -6.3 3.0e-10 -0.58 0.02 0.33 FALSE
112 The Cancer Genome Atlas Stomach Adenocarcinoma C1QTNF4 0.06 0.04 lasso 4 0.03 4.3e-03 -5.98 6.2 5.2e-10 0.24 0.05 0.28 FALSE
113 The Cancer Genome Atlas Stomach Adenocarcinoma ZNF408 0.11 0.04 enet 16 0.05 2.0e-04 8.18 -5.8 8.0e-09 -0.72 0.00 0.79 FALSE
114 The Cancer Genome Atlas Testicular Germ Cell Tumors MADD 0.21 0.04 blup 64 0.07 1.3e-03 7.88 -6.9 4.5e-12 -0.63 0.02 0.74 FALSE
115 The Cancer Genome Atlas Thyroid Carcinoma C1QTNF4 0.04 0.01 blup 15 0.03 7.9e-04 -6.10 6.9 5.4e-12 0.37 0.03 0.32 FALSE
116 The Cancer Genome Atlas Thyroid Carcinoma DDB2 0.06 0.04 enet 17 0.03 1.3e-03 8.06 6.7 2.3e-11 0.60 0.01 0.98 FALSE
117 The Cancer Genome Atlas Thyroid Carcinoma MADD 0.07 0.00 enet 11 0.03 6.7e-04 7.67 -6.0 1.5e-09 -0.57 0.02 0.68 FALSE
118 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma ZNF408 0.27 0.01 blup 27 0.09 1.5e-03 8.18 -5.3 1.1e-07 -0.81 0.00 0.78 FALSE