Best TWAS P=3.64e-33 · Best GWAS P=8.31e-58 conditioned to 7.1e-113
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | HIBADH | 0.31 | 0.13 | enet | 20 | 0.11 | 1.2e-03 | -12.26 | 11.4 | 2.4e-30 | 0.02 | 0.16 | 0.45 | FALSE |
| 2 | GTEx | Brain Cerebellum | HIBADH | 0.19 | 0.17 | lasso | 3 | 0.14 | 5.2e-05 | -6.73 | 10.2 | 2.7e-24 | 0.06 | 0.30 | 0.18 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | HIBADH | 0.29 | 0.10 | lasso | 6 | 0.09 | 5.6e-04 | -12.52 | 10.2 | 2.2e-24 | -0.02 | 0.40 | 0.04 | TRUE |
| 4 | GTEx | Colon Transverse | HIBADH | 0.21 | 0.06 | lasso | 9 | 0.04 | 7.2e-03 | -6.93 | 6.9 | 6.3e-12 | 0.00 | 0.35 | 0.04 | TRUE |
| 5 | GTEx | Esophagus Mucosa | HIBADH | 0.13 | 0.09 | lasso | 4 | 0.10 | 1.8e-07 | -12.52 | 11.0 | 4.1e-28 | -0.01 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | CTB-119C2.1 | 0.10 | 0.01 | lasso | 2 | 0.00 | 2.9e-01 | -3.73 | 7.0 | 2.8e-12 | -0.30 | 0.04 | 0.39 | TRUE |
| 7 | GTEx | Lung | HIBADH | 0.22 | 0.11 | enet | 13 | 0.16 | 2.8e-12 | -5.38 | 7.2 | 7.1e-13 | 0.01 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Testis | TAX1BP1 | 0.31 | 0.28 | enet | 15 | 0.28 | 9.0e-13 | -12.26 | -11.1 | 1.5e-28 | -0.02 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Testis | AC004549.6 | 0.18 | 0.02 | lasso | 6 | 0.02 | 4.0e-02 | -10.50 | -12.0 | 3.6e-33 | 0.02 | 0.20 | 0.20 | TRUE |
| 10 | METSIM | Adipose | SKAP2 | 0.08 | 0.02 | enet | 29 | 0.05 | 3.2e-08 | -3.85 | -8.7 | 4.8e-18 | 0.16 | 0.86 | 0.02 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | TAX1BP1 | 0.10 | 0.03 | bslmm | 515 | 0.07 | 8.3e-09 | 3.64 | -6.5 | 6.2e-11 | -0.06 | 0.87 | 0.12 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | AC003090.1 | 0.14 | 0.03 | lasso | 6 | 0.10 | 2.1e-12 | -13.97 | -12.0 | 4.7e-33 | 0.61 | 0.36 | 0.64 | TRUE |
| 13 | YFS | Blood | HIBADH | 0.10 | 0.04 | bslmm | 528 | 0.09 | 4.5e-28 | -9.51 | -8.2 | 3.0e-16 | -0.03 | 1.00 | 0.00 | TRUE |
| 14 | YFS | Blood | TAX1BP1 | 0.02 | 0.01 | bslmm | 522 | 0.02 | 1.7e-06 | 3.21 | -7.0 | 3.1e-12 | -0.10 | 0.21 | 0.64 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | JAZF1 | 0.04 | 0.02 | blup | 224 | 0.03 | 3.8e-06 | -3.74 | -7.1 | 9.7e-13 | 0.02 | 0.77 | 0.01 | TRUE |
| 16 | The Cancer Genome Atlas | Esophageal Carcinoma | EVX1 | 0.16 | 0.02 | blup | 50 | 0.12 | 1.4e-04 | -9.05 | 7.7 | 1.1e-14 | 0.01 | 0.01 | 0.41 | TRUE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HIBADH | 0.03 | 0.00 | blup | 82 | 0.01 | 1.8e-02 | 0.65 | 5.6 | 2.1e-08 | -0.04 | 0.04 | 0.55 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | HIBADH | 0.19 | 0.11 | lasso | 2 | 0.11 | 4.0e-05 | 5.29 | -8.3 | 1.3e-16 | -0.07 | 0.09 | 0.46 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | HOXA9 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.4e-04 | 7.19 | -6.0 | 2.5e-09 | 0.01 | 0.53 | 0.02 | FALSE |