Hub : Genes

FAM213A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0920	0.0360	4.3e-04	0.013	NA	0.023	NA	0.013	2.6e-02	NA	4.7e-03	NA	2.7e-02
2	GTEx	Brain Frontal Cortex BA9	0.2936	0.1110	1.4e-03	0.133	NA	0.062	NA	0.105	2.3e-04	NA	9.7e-03	NA	1.0e-03
3	GTEx	Cells Transformed fibroblasts	0.5910	0.0730	5.7e-06	-0.002	NA	-0.002	NA	-0.003	4.9e-01	NA	4.6e-01	NA	5.9e-01
4	GTEx	Esophagus Mucosa	0.2310	0.0470	5.8e-14	0.250	NA	0.243	NA	0.247	9.0e-17	NA	2.7e-16	NA	1.4e-16
5	GTEx	Skin Sun Exposed Lower leg	0.1190	0.0380	1.0e-05	0.124	NA	0.105	NA	0.133	2.1e-10	NA	5.2e-09	NA	3.9e-11
6	GTEx	Spleen	0.5160	0.1070	3.8e-04	-0.007	NA	0.146	NA	0.152	5.4e-01	NA	1.4e-04	NA	1.0e-04
7	GTEx	Testis	0.1420	0.0640	4.1e-03	0.078	NA	0.004	NA	0.025	2.4e-04	NA	2.0e-01	NA	2.7e-02
8	GTEx	Thyroid	0.1100	0.0410	6.3e-05	0.046	NA	0.052	NA	0.063	1.9e-04	NA	7.1e-05	NA	1.4e-05
9	METSIM	Adipose	0.0370	0.0184	7.9e-03	0.005	0.004	0.007	0.006	0.003	5.1e-02	0.0720	2.9e-02	0.0390	8.6e-02
10	ROSMAP	Brain Pre-frontal Cortex	0.0324	0.0143	2.5e-03	0.010	0.017	0.008	0.013	0.008	1.8e-02	0.0022	2.6e-02	0.0069	3.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.0	1.6	5.1	-1.4	-0.1	2.3	-0.1	0.1	2.2	-0.6	-0.8	1.5	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	4.5	-1.0	0.4	0.6	-1.5	-2.1	-0.6	0.4	0.1	-1.2	-1.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	-0.1	0.6	-1.2	0.6	0.5	0.4	-0.3	0.0	-0.6	1.2
Depression (Nagel 2018)	0.3	0.4	1.6	-0.7	-0.6	0.3	0.3	0.4	1.3	-0.4	-0.6	-0.3	0.8
Intelligence (Savage-Jansen 2018)	1.7	5.3	10.1	2.5	2.2	-2.4	2.5	1.6	-0.2	2.6	2.7	-1.8	3.2
Neuroticism (Nagel 2018)	0.2	0.4	1.7	-0.4	0.3	-1.3	-0.2	-0.2	-0.8	-0.2	-0.1	-0.7	0.6
Schizophrenia (2018)	1.4	3.0	7.8	-0.2	0.6	-1.1	-1.9	-2.8	-2.6	1.0	0.8	-2.8	-1.0
Schizophrenia vs Biploar Disorder	1.3	1.7	5.4	0.5	0.8	-1.2	-0.5	-1.4	-2.3	1.3	0.9	-2.1	0.1
Worry (Nagel 2018)	0.3	0.7	5.1	-0.8	0.1	-0.7	-0.6	-0.5	-2.3	0.1	-0.3	-0.5	-0.4
Alzheimer’s Disease (in mother)	2.2	2.6	10.3	-3.2	-1.0	1.4	-2.0	-0.9	-0.2	-0.7	-1.3	1.6	-1.7
Alzheimer’s Disease (in father)	1.3	1.4	3.3	-0.5	-1.5	1.8	-1.6	-0.7	0.6	-1.4	-1.4	0.2	-0.9
Alzheimer’s Disease (including proxy)	3.0	4.4	9.5	-3.1	-2.1	2.1	-2.6	-2.1	0.9	-1.4	-2.1	1.2	-2.4
Crohns Disease (2017)	3.6	8.0	20.4	-3.5	-2.5	3.3	-4.5	-3.9	-0.9	-0.9	-2.0	0.7	-3.0
Irritable Bowel Disease (IBD)	3.3	7.8	20.8	-3.4	-1.9	3.8	-4.6	-3.3	-1.0	-1.4	-1.6	1.7	-2.9
Ulcerative Colitis (UC)	1.4	2.7	7.1	-1.9	-0.7	2.7	-2.4	-1.2	-0.5	-1.3	-0.7	2.1	-1.4
Major Depression (MDD)	1.6	1.9	6.6	-0.3	-1.2	1.6	-0.8	-0.3	2.6	-1.2	-1.5	0.9	-1.8
Reaction Time	0.7	1.3	5.2	-0.5	0.9	-0.5	0.6	0.3	-2.3	0.7	1.3	-1.7	0.8
Verbal and Numeric Reasoning (VNR)	1.7	4.1	7.7	2.2	2.0	-2.1	2.3	1.7	-1.2	1.8	2.5	-1.0	2.8
Breast Cancer	0.2	0.4	0.9	-0.0	0.7	0.5	0.8	0.9	0.8	0.9	0.4	0.6	0.4
Ovarian Cancer	0.6	0.8	2.5	0.2	-1.0	-0.6	0.8	1.2	1.6	-0.7	-0.6	0.9	0.3
Prostate Cancer	2.1	2.9	12.6	-2.0	-0.3	-0.8	-2.1	-2.2	-3.5	0.4	-0.4	-1.4	-0.6
Age at First Birth	3.9	5.7	10.6	-2.3	-2.6	2.5	-3.3	-3.0	0.7	-2.3	-2.5	0.5	-2.7
Bipolar Disorder (2011)	0.9	0.8	5.2	-0.8	-0.1	2.3	-0.6	-0.8	0.9	0.3	-0.2	0.2	-0.8
Body Mass Index (BMI) (2010)	0.8	1.1	2.9	1.4	0.8	-0.2	1.7	1.4	-0.5	0.7	0.9	-1.2	0.5
Coronary Artery Disease (CAD)	2.7	3.2	12.3	2.5	1.2	-0.5	2.7	3.5	1.3	-0.0	0.9	0.5	1.3
Crohns Disease (2012)	2.7	4.3	9.8	-1.4	-1.9	3.1	-3.1	-2.6	-1.3	-0.7	-1.5	0.1	-2.5
Mean Putamen Volume	0.3	0.3	1.2	0.0	-0.5	-0.5	-0.2	-0.2	-1.1	1.0	-0.2	-0.5	-0.5
Fasting Glucose	0.3	0.4	1.1	0.2	0.8	1.0	-0.4	-0.6	-0.6	0.0	0.9	0.5	0.5
HbA1C	0.7	0.8	2.8	1.7	0.1	-1.1	0.2	-0.8	-0.8	0.9	0.5	-0.8	0.9
HDL Cholesterol	0.8	1.4	2.8	-1.6	-1.5	0.5	-1.2	-1.2	0.0	-1.2	-1.7	-0.3	-1.0
LDL Cholesterol	2.4	3.8	8.0	-1.2	-2.6	1.9	-2.1	-1.5	0.9	-1.9	-2.7	0.6	-2.8
Lupus	0.4	0.5	2.2	0.5	0.2	0.3	-0.5	-0.9	-1.5	-0.3	0.1	-0.9	-0.8
Neuroticism (2016)	0.3	0.5	1.6	-0.8	0.2	0.1	0.4	0.7	1.3	-0.8	-0.4	1.1	0.1
Primary Biliary Cirrhosis	0.9	1.3	7.3	2.7	-0.5	-0.8	1.2	1.3	-0.8	-0.6	-0.3	0.1	0.4
Rheumatoid Arthritis	6.7	9.3	21.2	2.3	4.1	-2.3	3.4	2.8	-0.1	2.8	4.6	-2.3	3.3
Schizophrenia (2014)	1.2	2.5	8.5	-0.8	-0.1	0.1	-2.1	-2.9	-2.0	0.8	0.1	-2.3	-1.4
Triglycerides	0.1	0.1	0.6	0.3	0.1	0.1	-0.3	-0.1	0.8	0.1	-0.1	0.3	-0.5
Type 2 Diabetes (T2D) (2012)	0.8	1.0	3.5	0.9	-0.2	0.5	-0.5	-1.0	-1.9	1.1	0.9	-1.2	0.2
Ulcerative Colitis	1.2	1.8	5.8	-0.5	-0.3	2.4	-1.8	-0.4	-0.6	-1.2	-0.5	1.8	-1.7
Blood Eosinophil Count	0.2	1.7	3.4	-1.4	-1.4	0.4	-1.6	-1.9	-1.3	-0.8	-1.6	0.3	-1.4
Blood Platelet Count	0.8	9.2	20.1	2.3	3.8	-2.2	1.9	0.9	-4.5	2.8	4.2	-2.6	3.2
Blood Red Count	0.3	3.3	8.5	2.7	-1.6	1.2	1.8	2.9	0.9	-0.7	-1.4	2.4	0.7
Blood White Count	1.5	10.9	23.4	-1.2	-4.8	1.9	-3.7	-2.6	1.1	-4.1	-4.8	2.2	-3.8
Heel T-Score	3.1	24.9	58.7	-2.1	-7.7	4.9	-5.0	-3.1	1.8	-6.2	-6.7	3.8	-5.1
BMI	0.3	1.6	3.9	1.4	-0.5	-0.4	1.7	1.9	2.0	-0.3	-1.3	1.2	0.1
Height	0.2	4.4	9.1	-1.0	3.0	-0.9	0.9	-0.4	-2.8	2.7	2.9	-2.9	0.9
Waist Hip Ratio (WHR)	1.0	4.6	11.1	2.0	2.1	-0.7	3.3	3.3	-1.1	1.4	2.0	-0.9	2.6
Systolic Blood Pressure	3.9	19.8	35.9	4.4	6.0	-5.8	4.5	2.9	-0.9	4.3	5.4	-3.3	4.6
Smoking Status	0.0	0.1	0.4	-0.0	-0.3	-0.1	0.2	0.1	-0.3	0.6	-0.4	-0.1	0.2
Allergy or Eczema	0.5	1.3	5.2	0.8	1.3	-2.3	1.4	1.2	0.2	0.3	0.9	-0.6	0.9
Cardiovascular Disease	1.7	5.6	12.5	2.7	2.3	-2.4	3.5	3.3	0.2	1.2	1.6	-0.6	3.1
Hypothyroidism (self reported)	0.2	0.4	2.3	0.4	-0.3	-0.3	-0.3	-0.6	-1.5	0.8	-0.2	-0.6	0.2
Respiratory disease	3.4	7.6	11.4	2.7	2.8	-3.2	3.4	2.9	-0.8	3.1	2.5	-1.9	3.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.6	-0.8	-0.6	-1.4	-0.7	-1.1	-0.6	0.1	-0.1	-1.6	-0.8
Lung FEV1/FVC ratio	10.3	52.2	102.0	-4.5	-10.1	7.8	-7.0	-3.3	1.6	-9.5	-9.3	5.6	-8.2
Lung FVC	0.3	1.7	5.2	2.3	0.9	-1.0	1.0	0.4	-0.0	1.7	1.2	-1.2	1.6
Neuroticism	0.4	1.0	3.9	-0.2	0.9	-2.0	0.9	0.4	-1.1	0.6	0.7	-1.4	0.7
Chronotype (morning person)	1.2	2.8	6.9	2.4	1.9	-1.4	1.4	1.0	-2.6	1.1	2.2	-0.8	0.1
Hair Pigment	0.2	4.9	9.6	-2.1	-2.5	1.5	-3.1	-2.3	-0.6	-1.5	-2.7	1.2	-3.1
Tanning	0.8	10.3	18.2	2.5	3.4	-2.0	3.8	3.2	-1.2	4.1	4.1	-2.0	4.3
Hand grip strength (left)	0.8	2.0	4.2	1.7	1.4	-1.2	0.8	0.6	-2.1	1.3	1.8	-1.6	1.1
Number of treatments/medications taken	2.6	4.7	10.4	1.5	3.2	-2.3	2.5	1.4	0.2	2.5	2.6	-1.9	2.2
Average weekly spirits intake	0.1	0.1	0.4	-0.2	-0.1	0.5	0.6	0.5	0.2	-0.3	-0.3	0.1	0.0
Sensitivity / hurt feelings	0.2	0.4	1.4	-1.2	0.1	-0.2	-0.7	-1.0	-0.2	0.5	-0.2	0.3	-0.5
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-0.3	1.2	-0.8	1.1	0.9	0.5	0.9	0.3	-0.0	1.3
Hearing difficulty/problems: Yes	1.9	2.9	5.8	1.9	2.3	-1.0	2.4	2.2	-1.7	0.7	1.9	-0.3	1.5
Relative age of first facial hair	0.9	1.9	4.8	1.6	1.5	-1.3	0.7	-0.3	-0.7	1.6	2.2	-1.8	0.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.0	0.7	1.1	-0.3	1.4	1.7	0.3	0.5	0.8	1.4	0.8
Ever used hormone-replacement therapy (HRT)	2.5	3.1	7.4	1.5	2.5	-1.7	1.7	1.3	-0.8	2.7	1.8	-1.6	1.1
Ever had hysterectomy (womb removed)	0.6	0.7	2.6	-0.8	0.4	-1.6	0.7	0.5	0.5	1.2	0.2	0.2	0.9
Systolic blood pressure, automated reading	2.1	6.1	14.9	2.5	3.9	-3.1	2.7	1.7	0.4	2.2	3.1	-0.8	2.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.5	0.6	1.0	-1.0	0.7	0.3	-1.2	1.1	1.1	-1.1	0.8
Angina	1.3	1.7	5.0	-0.3	-1.2	1.9	0.4	1.0	1.4	-1.3	-1.5	2.2	-0.1
Medication for hormone replacement therapy	0.1	0.2	0.5	-0.5	-0.7	0.4	-0.3	0.0	0.0	-0.1	-0.4	0.1	-0.6
Vitamin and mineral supplements	0.9	1.2	4.2	1.4	-0.8	0.9	0.1	1.1	1.5	-0.3	-0.7	2.1	-0.9
Supplements: Zinc	1.1	1.2	4.1	-0.7	1.3	-1.2	0.1	-0.8	-2.0	0.7	0.8	-1.1	1.3
Medication: Co-codamol	1.7	2.0	3.9	1.9	1.9	-2.0	1.4	0.4	-0.5	1.1	1.9	-1.1	0.6
Medication: Metformin	1.3	1.8	5.6	-0.2	0.4	-0.5	-1.2	-1.9	-2.4	0.8	1.0	-2.3	-0.4
Diabetes (father)	0.8	1.0	2.5	0.1	1.6	-1.3	0.1	-0.7	0.1	1.4	1.1	-1.0	1.1
Diabetes (mother)	1.9	2.4	6.8	-0.3	-1.6	0.8	0.3	1.2	1.6	-2.6	-2.0	2.4	-0.5
Severe depression (siblings)	0.4	0.4	1.7	0.7	-1.3	0.4	-0.3	-0.4	0.8	-0.1	-0.8	0.1	-0.4
Pack years adult smoking proportion	0.9	1.4	3.2	1.7	1.2	-0.3	1.8	1.7	-0.0	0.9	1.4	-0.8	-0.1
Impedance of leg (right)	0.5	2.3	5.2	-0.3	2.3	-0.6	-0.1	-0.7	-2.1	1.7	2.2	-2.1	0.8
Leg fat-free mass (left)	0.1	0.4	1.1	0.2	0.7	-0.1	1.0	0.8	-0.2	1.1	0.5	-0.6	0.4
Trunk fat percentage	0.5	2.0	4.7	1.0	1.9	-0.6	2.2	1.6	1.1	1.7	1.2	-0.3	1.4
Hand grip strength (right)	1.5	4.2	8.3	1.4	2.5	-2.2	1.4	0.9	-2.5	1.5	2.6	-2.9	1.7
Townsend deprivation index at recruitment	0.5	0.7	2.0	0.7	0.5	-0.3	1.4	1.1	1.4	0.7	0.1	0.6	0.9
Current tobacco smoking	0.2	0.4	1.0	0.7	-0.6	1.0	0.9	0.8	0.4	-0.2	-0.1	0.2	-0.3
Average weekly fortified wine intake	0.5	0.6	1.8	1.2	-0.4	-0.9	0.2	-0.1	0.9	0.7	0.2	-1.3	0.5
Maternal smoking around birth	3.7	5.3	9.3	2.0	3.0	-1.8	3.1	2.7	1.5	1.9	2.7	-0.3	2.8
Fed-up feelings	0.3	0.5	1.0	0.9	0.1	-1.0	0.7	0.9	0.7	0.1	-0.0	0.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.5	-0.4	-0.5	1.1	-0.4	-0.3	1.6	-0.3	-1.0	0.6	-0.1
Relative age voice broke	0.8	1.2	2.7	0.7	1.5	-1.0	1.1	0.9	-0.1	1.4	1.6	-1.1	0.4
Taking other prescription medications	0.8	1.2	2.5	0.4	1.3	-1.1	1.6	1.4	-0.0	1.0	1.1	-1.0	1.0
Age when periods started (menarche)	2.2	5.3	10.3	-1.9	-3.0	1.4	-2.6	-2.3	0.5	-2.3	-3.2	1.5	-2.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-0.4	-0.5	-0.1	1.0	1.2	1.1	-0.1	-0.8	0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	4.4	10.0	22.7	-0.2	-4.8	3.5	-2.4	-1.1	2.1	-4.2	-4.5	2.9	-2.8
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.1	1.4	0.4	-1.8	1.7	1.6	-0.0	-0.6	0.6	-0.8	1.7
Qualifications: CSEs or equivalent	0.6	0.8	3.9	-0.7	-0.2	0.4	0.8	1.2	0.1	-0.9	-0.7	2.0	0.0
Serious illness, injury or assault to yourself	0.5	0.6	3.5	-0.3	1.2	0.4	0.1	0.2	-0.6	1.9	0.5	0.1	0.2
High blood pressure	1.7	4.7	10.7	2.8	2.1	-2.2	3.3	3.1	0.9	0.8	1.3	-0.6	2.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	0.7	1.0	-1.9	1.4	1.2	1.0	0.2	0.7	-0.1	0.9
Multivitamins +/- minerals	0.9	1.1	2.4	-1.1	0.9	-0.6	-0.5	-1.6	-1.5	1.0	0.8	-0.7	1.3
Stomach or abdominal pain in last month	0.3	0.3	2.6	-0.2	0.7	-0.4	-0.1	-0.0	-0.1	-0.2	-0.1	-1.6	-0.1
Supplements: Glucosamine	0.3	0.4	1.8	-0.2	0.8	-0.1	-0.6	-0.9	-0.2	0.6	0.6	-1.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.6	-0.4	-0.5	0.3	-0.5	0.2	-0.3	-0.5	-0.3	-0.9	-1.3
Medication: Atenolol	0.6	0.8	2.6	1.3	0.3	0.1	1.2	0.8	1.6	-1.0	-0.7	-0.3	0.2
Medication: Levothyroxine sodium	0.2	0.4	2.0	0.4	-0.4	0.2	0.1	-0.4	-1.4	1.0	0.0	-0.6	0.1
Sitting height	0.4	2.8	8.8	-3.0	-0.6	2.8	-1.7	-0.5	0.3	-0.6	-1.0	1.4	-2.0
Chronic bronchitis/emphysema (father)	0.6	0.7	1.7	-1.2	0.9	-1.3	0.1	-0.9	0.0	0.5	1.0	-0.9	0.6
High blood pressure (mother)	0.5	0.8	1.5	1.2	1.0	-0.6	0.9	1.2	-1.0	0.3	0.9	-0.5	0.7
Body mass index (BMI)	0.3	1.1	2.9	0.8	-0.2	0.1	1.2	1.6	1.7	-0.1	-1.0	1.6	-0.0
Impedance of leg (left)	0.4	2.0	4.1	-0.2	2.0	-0.7	0.1	-0.7	-1.8	1.6	1.9	-2.0	1.0
Leg predicted mass (left)	0.1	0.4	1.2	0.2	0.7	-0.1	0.9	0.8	-0.2	1.1	0.5	-0.5	0.4
Trunk fat mass	0.4	1.6	4.0	0.8	1.9	-0.5	2.0	1.6	0.8	1.7	1.0	-0.3	1.0
Waist circumference	0.6	2.4	7.0	1.4	1.5	-1.1	2.6	2.6	0.9	1.2	0.8	0.2	1.4
Number of incorrect matches in round	4.9	8.1	16.4	-3.0	-4.0	1.5	-2.6	-2.8	1.8	-3.5	-4.0	1.0	-2.4
Past tobacco smoking	0.2	0.4	1.0	0.6	-0.7	0.6	0.6	1.0	0.8	-0.3	-0.3	0.9	0.0
Alcohol usually taken with meals	0.6	1.0	2.5	-0.8	-0.9	1.2	-1.6	-1.4	-0.8	-0.7	-0.9	0.6	-0.7
Nervous feelings	1.2	2.2	3.8	-2.0	-1.5	0.3	-1.9	-1.6	-1.6	-1.2	-1.9	-0.2	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	1.1	-0.6	0.1	-0.1	-0.4	-0.2	0.5	0.2	-0.6	-0.5	-1.0
Hearing difficulty/problems with background noise	1.0	1.5	6.0	0.4	0.7	-0.6	2.0	2.4	-0.5	-1.0	0.7	0.9	1.5
Hair/balding pattern: Pattern 2	0.5	0.6	3.4	-0.7	0.9	1.9	0.1	0.6	0.3	0.2	0.7	0.6	-0.1
Had menopause	0.9	1.2	4.5	0.9	1.2	-1.1	0.9	0.3	0.4	2.1	0.8	-1.1	1.0
Had other major operations	0.2	0.2	0.6	-0.8	0.3	0.4	-0.2	-0.6	-0.4	-0.0	-0.2	0.4	-0.6
Forced vital capacity (FVC)	0.7	2.9	7.4	1.2	2.4	-1.1	0.8	0.1	-1.3	2.3	2.7	-1.5	1.7
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.6	20.1	-0.8	-4.5	3.8	-2.5	-1.4	2.1	-3.6	-4.3	2.8	-3.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	5.6	-1.3	-1.6	1.6	-0.5	-0.4	2.4	-1.3	-1.4	0.4	-1.2
Qualifications: None of the above	0.7	1.5	3.1	0.3	1.1	-1.8	1.3	0.8	1.1	1.0	1.5	-1.7	1.0
Financial difficulties in last 2 years	0.6	0.9	2.5	0.2	1.5	0.4	1.6	1.4	0.2	0.7	0.9	0.5	0.2
Mouth/teeth dental problems	1.0	1.6	3.6	-0.3	-1.9	1.3	-1.3	-0.9	1.0	-1.1	-1.8	1.1	-0.9
Heart attack	0.7	0.9	3.5	0.2	-0.4	1.9	0.0	0.6	0.3	-0.8	-1.3	1.2	-0.9
Allergy	0.6	1.4	3.6	-1.1	-0.7	1.6	-1.9	-1.7	-1.0	-0.4	-0.4	0.1	-1.3
Pain all over the body in last month	0.3	0.4	1.4	-0.0	-0.5	-0.8	-0.2	-0.5	-0.8	0.6	0.0	-1.2	0.0
Diabetes (self-reported)	0.3	0.5	2.2	0.2	-0.5	-0.7	-0.4	-0.5	-1.5	0.8	0.4	-1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.6	0.8	1.3	-1.6	1.1	0.4	-0.8	0.9	1.3	-0.9	0.9
Medication: Ramipril	0.5	0.6	1.3	-0.6	1.1	-0.9	1.1	1.2	-0.2	0.8	0.3	-0.5	0.8
Medication: Simvastatin	1.3	2.0	7.1	1.7	1.0	-1.1	2.0	2.7	1.2	0.2	0.4	0.6	1.3
Fluid intelligence score	1.0	2.0	4.7	1.2	1.5	-1.2	1.0	0.3	-2.0	1.5	1.7	-0.1	2.2
Illnesses of siblings	1.7	2.4	5.3	-1.9	-2.2	1.1	-2.3	-2.0	0.7	-0.6	-1.6	0.1	-1.4
Neuroticism score	0.2	0.4	1.4	-0.6	0.2	-0.9	-0.1	-0.4	-1.2	-0.1	-0.1	-1.0	-0.4
Weight	0.2	1.0	2.4	0.5	1.4	-0.5	1.5	1.4	0.2	1.6	0.6	-0.1	0.7
Impedance of arm (right)	0.8	3.6	8.1	0.5	2.6	-1.4	1.0	-0.1	-1.4	1.7	2.9	-2.8	2.2
Arm fat percentage (right)	0.3	1.3	4.2	1.1	1.1	-0.4	2.0	2.0	1.0	0.6	0.3	0.2	1.0
Trunk fat-free mass	0.1	0.7	2.1	-0.4	1.0	0.4	0.6	0.9	-1.4	1.4	0.6	-0.5	-0.2
Hip circumference	0.2	0.9	2.6	0.8	1.2	-1.0	1.1	1.1	0.7	1.6	0.4	0.1	0.4
Time employed in main current job	1.5	1.7	3.6	0.2	-1.7	1.6	-0.8	0.3	0.8	-1.9	-1.6	1.8	-0.9
Alcohol intake versus 10 years previously	0.5	0.7	3.5	-0.5	0.9	-0.1	0.9	0.5	0.5	1.9	0.7	-0.4	0.9
Father’s age at death	1.2	1.7	4.8	-1.0	-1.1	1.3	-2.2	-1.7	-0.6	-0.1	-1.0	1.7	-0.9
Worrier / anxious feelings	0.4	0.8	2.0	-1.1	1.4	-0.7	0.1	-0.4	-1.1	0.4	1.1	-0.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.4	0.5	0.7	-1.5	1.3	1.1	1.2	1.0	0.2	0.3	1.1
Falls in the last year	0.9	1.3	3.8	-0.3	1.5	-0.3	1.6	1.9	-0.2	1.6	0.9	0.5	0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.7	-0.0	0.0	-0.8	-0.2	-0.2	0.0	-0.5	0.1	-0.4	-0.5
Number of live births	0.9	1.3	4.2	1.0	-0.1	-2.1	0.1	-0.6	-0.8	1.7	0.0	-1.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.1	-0.3	-0.7	1.2	-1.5	-1.1	-1.1	-0.5	-0.2	0.1	-0.8
Pulse rate	0.4	0.7	3.3	0.5	-1.4	0.0	0.1	0.4	1.8	-0.3	-1.0	-0.0	-0.2
Happiness	0.9	1.0	2.9	-1.1	-1.1	0.7	0.1	0.5	1.7	-1.2	-1.3	0.9	-0.0
Noisy workplace	0.9	1.1	3.3	0.7	-1.5	0.5	-0.4	0.0	0.4	-1.3	-1.6	0.6	-1.8
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.8	0.4	0.4	-0.6	-0.9	-1.9	-0.3	1.0	1.0	-1.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	0.7	0.5	0.2	-0.3	-0.5	0.9	1.3	0.4	0.7	0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	-0.9	-0.3	-0.0	-0.5	-1.0	-0.7	0.3	-0.2	-0.3	-0.5
Asthma	2.7	5.3	11.1	2.8	1.7	-2.3	3.3	3.1	0.2	2.0	1.8	-1.4	2.7
Medication: Ibuprofen (e.g. Nurofen)	2.7	3.4	7.3	0.7	2.3	-1.6	1.9	0.7	-0.0	2.3	2.7	-2.5	1.5
Medication: Cholesterol lowering	0.3	0.5	1.5	0.9	-0.0	-0.1	0.7	1.2	0.5	-0.6	-0.2	1.1	0.2
Depression (self-reported)	0.4	0.5	1.8	0.5	-1.0	-0.2	0.6	0.4	1.3	0.3	-1.0	0.6	0.0
Medication: Lansoprazole	0.5	0.5	1.6	0.8	0.0	1.0	0.3	0.9	-1.1	-0.2	-0.2	1.3	-0.2
Prospective memory result	4.4	5.4	12.1	-2.3	-2.2	2.4	-2.2	-1.4	0.9	-2.1	-3.5	1.8	-3.3
Lung cancer (father)	0.9	1.0	2.3	-1.4	0.8	-0.4	-0.8	-1.5	0.2	1.5	1.1	-0.8	-0.3
Illnesses of mother	0.7	0.9	3.5	0.3	0.3	-0.4	-0.7	-1.3	0.0	1.9	1.0	-1.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.8	-0.1	-1.2	1.1	-1.7	-1.3	-0.7	-0.7	-0.6	0.1	-1.3
Pulse wave Arterial Stiffness index	1.0	1.1	3.0	0.7	0.9	-0.5	1.7	1.7	0.4	0.0	0.7	1.3	1.1
Impedance of arm (left)	0.7	3.1	7.5	0.4	2.5	-1.0	0.5	-0.7	-1.1	1.9	2.7	-2.7	1.8
Arm fat mass (right)	0.3	1.1	3.5	0.8	1.2	-0.2	1.8	1.9	0.6	1.1	0.3	0.5	0.8
Trunk predicted mass	0.1	0.8	2.3	-0.5	1.0	0.4	0.6	0.9	-1.5	1.5	0.7	-0.6	-0.2
Standing height	0.7	6.8	15.4	-0.7	3.5	-0.9	0.6	-0.6	-3.4	3.9	3.6	-3.5	1.5
Length of working week for main job	1.3	1.4	3.8	0.4	-0.8	-0.0	-2.0	-1.8	1.1	-0.9	-1.4	1.3	-1.0
Exposure to tobacco smoke at home	1.3	1.5	3.1	-0.7	1.6	-1.0	1.8	1.8	0.5	0.2	1.2	-1.0	1.2
Breastfed as a baby	1.1	1.3	3.2	0.2	-1.2	0.9	-1.0	-0.1	0.8	-1.7	-1.4	1.8	-1.2
Tense / ‘highly strung’	0.3	0.5	1.8	-0.5	-0.4	-0.6	-0.6	-0.8	-1.3	0.0	-0.6	-1.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.5	-0.9	-0.2	0.4	0.6	0.5	0.4	-0.5	0.1	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	2.0	1.1	-0.5	0.0	0.0	0.5	0.7	-0.1	-0.4	1.4	0.3
Birth weight of first child	4.7	8.6	14.8	-3.4	-3.2	3.0	-3.8	-2.8	-1.7	-2.7	-3.0	1.3	-3.3
Peak expiratory flow (PEF)	1.2	2.8	7.0	-1.4	-1.6	1.1	-2.6	-2.1	1.1	-1.5	-1.7	0.9	-1.9
Pulse wave reflection index	0.4	0.5	1.7	0.1	0.2	0.2	1.3	1.3	0.3	-0.7	0.0	1.1	0.3
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.8	-0.6	-0.8	0.3	0.6	1.4	2.0	-1.3	-1.1	0.4	-0.1
Loud music exposure frequency	0.5	0.6	1.4	-0.4	-0.9	0.5	-1.1	-1.2	-0.3	-0.3	-1.1	-0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	1.7	2.6	6.3	1.4	2.0	-0.7	1.0	-0.0	-1.2	2.5	2.3	-1.4	2.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.0	1.4	0.3	0.0	0.7	1.2	0.7	-0.3	0.3	0.4	0.5
Blood clot in the leg (DVT)	3.7	4.8	8.4	-2.0	-2.5	1.9	-2.6	-2.4	1.4	-2.3	-2.9	1.3	-2.3
Medication: Paracetamol	1.9	3.1	8.8	-0.5	3.0	-0.9	1.6	0.7	-0.1	2.4	2.4	-2.1	1.6
Headache pain in last month	1.9	3.3	9.5	1.0	3.1	-0.2	2.6	2.0	0.4	1.9	2.4	-0.3	1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	-1.2	-0.0	0.7	-1.0	-1.5	0.8	0.2	0.4	-0.7	0.1
Glaucoma (self-reported)	1.9	2.3	5.4	-1.7	-1.7	0.3	-1.8	-2.3	-1.6	-0.8	-1.1	-1.6	-1.3
Gout (self-reported)	0.6	0.9	2.3	-0.4	-1.3	0.7	-1.3	-0.9	0.7	-1.5	-0.7	0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	1.1	3.8	-0.3	-1.1	0.6	-1.3	-1.6	-1.9	0.2	-0.8	-0.1	-0.3
Medication: Amlodipine	2.1	3.0	8.5	2.1	1.9	-0.1	2.9	2.8	0.1	0.3	1.9	-0.4	1.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.7	-0.0	1.3	-0.9	1.5	1.6	-0.0	0.7	1.0	-0.5	1.4
Birth weight	3.1	6.7	11.8	-2.3	-3.4	2.3	-3.2	-2.0	1.4	-2.8	-3.0	1.9	-2.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.7	-1.2	0.2	0.4	0.8	1.0	1.2	-1.3	0.1	1.1	0.3
High blood pressure (siblings)	1.3	1.9	4.9	1.5	2.2	-1.2	2.0	1.5	-0.9	0.7	1.3	-0.3	1.3
Forced vital capacity (FVC), Best measure	0.4	1.6	4.1	1.1	1.7	-0.9	0.4	0.1	-0.9	1.9	2.0	-1.3	1.1
Body fat percentage	0.4	1.5	3.5	1.0	1.7	-0.8	1.9	1.4	0.9	1.4	0.9	-0.2	1.0
Leg fat percentage (right)	0.2	0.7	1.7	0.7	1.1	-0.6	1.2	1.2	1.3	0.4	0.1	0.3	0.4
Arm fat-free mass (right)	0.1	0.4	1.7	-0.5	0.4	0.8	0.4	0.5	-0.4	1.3	-0.0	0.2	-0.5
Exposure to tobacco smoke outside home	3.5	4.7	10.4	1.3	3.2	-2.1	2.8	1.9	0.4	2.0	2.6	-1.7	2.3
Comparative body size at age 10	0.7	2.0	6.0	-0.1	-1.4	2.4	-0.6	0.6	0.8	-2.1	-1.2	1.6	-1.4
Number of full brothers	1.4	1.8	3.6	1.9	1.9	-0.9	1.2	1.3	1.0	1.3	1.8	-0.0	0.9
Worry too long after embarrassment	0.1	0.2	0.4	0.6	0.6	-0.4	-0.1	-0.1	-0.6	0.7	0.4	-0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.1	-0.8	-0.9	0.3	-0.0	0.4	-0.0	-1.0	0.1	-0.6
Wheeze or whistling in the chest in last year	0.8	1.4	4.0	1.2	0.6	-0.3	2.0	1.9	1.1	1.1	0.6	0.0	1.4
Number of children fathered	0.4	0.4	1.0	-0.6	0.2	1.0	-1.0	-0.7	0.2	-0.5	-0.0	0.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	4.3	-1.9	-2.0	0.9	-1.4	-0.6	-0.5	-2.0	-2.1	1.8	-0.8
Age at first live birth	0.3	0.6	1.3	-0.5	-0.8	0.6	-1.1	-1.1	-0.5	-0.2	-0.4	-1.0	-0.7
Pulse wave peak to peak time	0.8	1.0	2.6	-0.8	-0.7	0.5	-1.6	-1.6	-0.7	0.1	-0.5	-1.3	-0.9
Health satisfaction	1.4	1.8	6.0	1.3	0.7	-1.3	2.5	2.0	1.1	0.2	0.4	-0.1	1.5
Shortness of breath walking on level ground	0.5	0.5	1.6	-0.1	0.4	0.2	1.0	0.2	1.3	1.1	0.3	-0.9	0.7
Qualifications: College or University degree	0.3	1.0	4.3	-0.6	-0.6	0.6	-1.7	-2.1	0.1	0.5	-0.5	-0.4	-1.0
Eye problems/disorders: None of the above	0.7	0.8	2.0	0.0	1.4	-0.5	-0.7	-1.3	-0.8	1.0	1.2	-0.8	-0.4
Mouth/teeth dental problems: Loose teeth	1.7	2.0	5.4	0.2	1.7	-1.8	0.6	-0.2	-0.3	2.3	1.9	-2.0	0.6
Emphysema/chronic bronchitis	1.3	1.5	3.9	-0.3	1.1	-1.2	2.0	1.3	-0.1	0.9	1.0	-1.2	1.7
Medication for pain relief, constipation, heartburn	2.8	4.7	10.8	-0.7	-3.3	2.1	-2.2	-0.8	0.6	-2.8	-3.1	2.0	-2.0
Neck or shoulder pain in last month	0.7	0.9	6.5	-2.5	1.1	0.2	0.4	0.0	-0.7	0.8	0.3	-0.1	-0.1
Medication: Blood pressure	0.6	1.1	4.2	0.9	1.0	-1.0	1.8	2.0	0.1	-0.3	0.0	0.5	0.2
Angina (self-reported)	1.2	1.6	5.3	-0.1	-1.2	1.6	0.7	1.3	1.4	-1.1	-1.4	2.3	0.3
Migraine (self-reported)	1.4	1.7	5.8	-0.4	2.4	-1.4	1.0	0.4	0.1	1.7	2.0	-0.8	1.0
Medication: Ibuprofen	2.7	3.3	7.4	0.8	2.7	-1.5	1.7	0.5	0.7	2.2	2.5	-2.5	1.3
Medication: Allopurinol	0.7	0.9	2.3	-0.4	-1.3	1.0	-0.8	-0.3	1.5	-1.3	-0.6	0.5	-0.7
Medication: Omeprazole	0.7	0.8	2.9	0.5	1.4	-1.7	1.2	0.6	-0.6	0.3	0.6	-0.2	0.5
Medication: Seretide 50 evohaler	1.7	2.0	4.1	1.7	1.3	-2.0	2.0	1.5	0.5	0.2	1.3	-0.2	1.7
Mean time to correctly identify matches	0.8	1.6	4.4	-0.7	1.2	-0.8	1.0	0.6	-2.1	1.2	1.6	-1.7	1.1
Heart disease (mother)	1.1	1.3	3.0	-0.7	-1.1	0.9	-0.3	0.6	1.6	-1.7	-1.4	1.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.2	-0.2	-0.4	0.1	-0.2	-0.4	0.6	0.2	-1.0	0.5
Whole body fat mass	0.3	1.1	3.0	0.5	1.5	-0.5	1.7	1.5	0.6	1.4	0.7	-0.1	0.7
Leg fat mass (right)	0.1	0.4	1.1	0.4	0.8	-0.3	1.0	1.0	0.7	0.6	-0.2	0.1	0.1
Arm predicted mass (right)	0.1	0.6	3.2	-0.0	0.8	0.2	0.9	0.9	-0.4	1.8	0.4	-0.1	-0.2
Pulse rate, automated reading	0.2	0.8	1.8	0.2	-1.0	0.5	0.1	0.6	1.3	-1.3	-1.0	1.2	-0.2
Alcohol intake frequency.	1.9	4.5	10.0	1.2	3.2	-2.0	2.7	2.1	0.0	2.7	2.1	-1.1	2.0
Comparative height size at age 10	0.5	2.5	6.8	-0.7	2.6	-1.1	1.4	0.6	-1.2	2.0	1.9	-1.7	1.4
Number of full sisters	0.3	0.4	1.1	0.5	0.1	-0.2	1.0	0.8	1.1	0.1	0.1	-0.7	0.1
Suffer from ‘nerves’	0.4	0.6	1.7	0.2	-0.1	-1.3	0.9	0.9	-0.6	0.8	-0.3	0.3	1.1
Overall health rating	4.1	8.9	15.7	1.4	3.7	-3.2	4.0	2.9	0.2	3.3	3.2	-2.0	3.7
Chest pain or discomfort	0.4	0.6	2.0	0.5	0.9	-0.7	1.3	0.9	0.2	1.4	0.4	-0.1	0.4
Had major operations	0.6	0.7	1.6	-1.2	-0.8	0.7	-1.0	-0.7	0.0	-0.2	-0.6	1.1	-1.1
Age at last live birth	2.0	2.8	9.4	-1.0	-2.0	0.3	-2.5	-3.1	-1.1	-0.6	-1.3	-1.3	-1.6
Family relationship satisfaction	1.0	1.2	3.4	-0.2	-0.4	-0.1	1.1	1.6	0.9	-1.7	-0.7	1.9	-0.3
Leg pain on walking	0.2	0.3	1.3	0.3	0.1	-0.1	0.9	0.3	0.0	0.6	0.4	-0.0	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.2	6.4	-1.5	-1.9	1.2	-1.7	-1.4	0.5	-2.2	-2.4	1.5	-2.5
Commuting to job workplace: Car/motor vehicle	1.8	2.0	5.4	-0.8	-1.3	2.3	-0.8	0.2	1.3	-2.1	-1.6	1.0	-1.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.1	0.7	-0.3	-2.2	0.6	0.3	-2.3	-0.2	0.7	-1.4	1.1
Medication: Aspirin	0.7	1.0	2.1	1.1	0.9	-1.2	1.4	1.4	-0.1	0.9	0.6	0.4	0.9
Supplements: Vitamin C	0.6	0.7	1.9	-1.4	0.1	-0.2	-0.7	-0.4	-0.7	-1.0	-0.8	0.4	-1.3
Knee pain experienced in last month	5.6	8.7	22.3	2.8	3.8	-1.3	4.7	4.2	0.3	2.1	3.0	-0.4	3.1
Hypertension (Self-reported)	1.7	4.7	10.1	2.6	2.2	-2.4	3.2	2.9	0.4	1.0	1.5	-0.8	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	0.5	-0.3	0.5	0.0	0.0	0.8	-1.1	-0.6	1.0	-0.5
Illnesses of father: Heart disease	2.1	2.9	12.9	3.6	0.7	-0.8	2.3	2.1	0.7	-1.0	0.1	0.6	1.8
Illnesses of siblings: Diabetes	1.1	1.4	2.9	0.4	1.5	-1.6	0.8	-0.2	-0.6	1.3	1.5	-1.7	1.1
Smoking status: Previous	0.5	0.7	1.9	-0.9	0.6	-1.1	-0.9	-1.0	-1.4	0.3	0.3	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.9	-0.3	1.6	-1.1	1.2	1.3	-0.9	1.2	1.7	-0.9	1.2
Whole body fat-free mass	0.1	0.5	1.8	-0.3	0.8	0.3	0.8	0.9	-0.6	1.3	0.5	-0.5	0.1
Leg fat-free mass (right)	0.1	0.3	0.9	0.2	0.5	0.0	0.9	0.8	0.1	0.9	0.2	-0.3	0.4
Arm fat percentage (left)	0.3	1.1	3.3	1.2	0.9	-0.2	1.8	1.8	1.3	0.5	0.1	0.4	0.7
Average weekly red wine intake	1.0	1.4	3.1	-0.5	-1.0	1.2	-1.8	-1.4	1.2	-1.1	-1.4	1.0	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.1	1.1	-0.4	-0.9	-0.5	-0.2	0.5	-0.6	-0.1	-0.1	-0.4
Mood swings	0.1	0.2	0.6	-0.8	-0.3	0.1	-0.3	-0.2	0.5	-0.7	-0.3	-0.1	-0.1
Loneliness, isolation	1.0	1.4	4.0	0.0	1.8	-0.6	1.1	0.2	-1.5	2.0	1.1	-1.1	1.0
Long-standing illness, disability or infirmity	0.8	1.2	2.5	0.5	1.3	-1.6	1.4	1.0	0.1	1.0	1.1	-0.8	1.3
Ever had bowel cancer screening	6.9	8.0	14.3	-3.8	-3.1	2.6	-3.6	-3.1	0.9	-2.4	-3.5	1.4	-2.5
Diabetes diagnosed by doctor	0.4	0.7	2.3	0.1	-0.4	-0.9	-0.7	-0.8	-1.5	0.7	0.2	-1.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.7	-1.9	0.2	-0.9	-0.8	-0.9	-1.5	1.0	0.3	-1.5	-0.7
Friendships satisfaction	0.6	0.8	1.6	0.6	0.5	-1.2	1.2	1.0	-0.7	0.2	1.0	-0.0	1.1
Qualifications: nursing, teaching	0.7	1.1	3.6	-0.5	-0.2	0.6	-1.6	-1.9	-0.4	0.1	0.1	-1.7	-1.0
Commuting to job workplace: Walk	2.4	2.6	4.8	2.2	1.7	-1.9	0.8	0.2	-1.2	1.8	1.9	-1.8	1.6
Eye problems/disorders: Cataract	1.0	1.2	4.6	0.6	-0.1	0.1	1.7	2.1	1.0	-0.2	0.0	1.0	1.4
Mouth/teeth dental problems: Mouth ulcers	4.0	6.4	12.7	1.8	3.6	-2.6	2.8	2.3	-1.4	2.5	3.4	-0.9	2.8
Medication for cholesterol	0.8	1.2	3.0	-0.7	-1.5	0.5	-1.5	-1.7	-0.7	-0.1	-0.8	0.2	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.9	-0.6	0.5	0.6	-0.3	-0.4	1.4	-1.2	-0.3	0.9	-0.4
Back pain experienced in last month	0.7	1.1	2.3	-1.5	-0.8	0.9	-0.2	0.2	1.0	-1.2	-1.4	1.5	-0.5
Mineral and other dietary supplements	0.5	0.6	2.1	0.8	-0.7	0.8	1.1	1.4	0.8	-0.2	-0.3	0.8	-0.0
Breast cancer (self-reported)	0.6	0.7	2.2	-0.6	0.8	0.9	0.2	1.5	1.1	-0.5	-0.4	0.6	-1.1
Asthma (self-reported)	3.7	7.4	14.3	3.1	2.3	-2.8	3.8	3.4	0.0	2.5	2.3	-1.8	3.3
Osteoporosis (self-reported)	0.6	0.8	2.5	0.5	0.8	-1.5	0.4	0.5	0.3	1.6	1.1	-0.7	-0.0
Osteoarthritis (self-reported)	0.9	1.2	2.6	1.2	0.6	-1.6	1.5	1.4	0.0	0.5	0.9	-1.1	0.6
Medication: Aspirin	0.6	0.8	1.5	1.1	0.6	-0.8	1.1	1.2	0.3	0.6	0.2	1.1	1.0
Medication: Gliclazide	0.6	0.6	1.5	-0.9	-0.8	0.4	-1.2	-1.0	-0.2	-1.0	-0.2	-0.6	-0.9
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	-1.1	-1.1	0.2	-1.4	-1.0	-0.7	-0.6	-0.6	-0.7	-1.3
Smoking status: Current	0.2	0.3	1.3	0.5	-0.6	1.1	0.7	0.6	0.4	-0.2	-0.3	0.4	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.2	0.0	-1.5	1.7	-1.5	-0.4	0.1	-0.9	-1.4	1.8	-1.6
Whole body water mass	0.1	0.5	1.9	-0.3	0.8	0.3	0.9	0.9	-0.7	1.4	0.5	-0.4	0.1
Leg predicted mass (right)	0.1	0.3	0.9	0.2	0.4	0.1	0.9	0.9	0.2	0.9	0.2	-0.2	0.4
Arm fat mass (left)	0.3	1.2	3.6	0.9	1.1	-0.2	1.9	1.9	0.7	1.0	0.3	0.5	0.8
Number of self-reported non-cancer illnesses	1.0	1.8	5.2	0.7	0.5	-1.8	2.3	2.2	0.0	0.7	-0.0	0.1	1.8
Average weekly champagne plus white wine intake	0.2	0.3	1.2	0.6	0.4	0.2	-0.9	-1.1	0.3	0.2	0.6	-0.1	0.4
Miserableness	1.0	1.7	3.8	1.0	1.3	-1.9	1.8	1.7	0.3	0.4	1.0	-0.4	1.7
Guilty feelings	0.7	1.0	3.1	0.1	-0.4	-0.1	0.6	1.3	1.0	-1.4	-1.2	1.8	-0.1
Wears glasses or contact lenses	1.0	1.1	2.5	-0.5	-1.0	-0.1	-1.4	-1.6	0.7	-0.0	-1.3	-1.4	-1.2
Ever taken oral contraceptive pill	1.3	1.5	5.2	2.3	0.6	-1.9	0.7	0.4	-1.7	0.6	-0.1	-0.6	1.0
Hearing aid user	2.9	3.2	6.4	2.3	2.2	-0.9	2.0	1.8	-2.2	1.0	2.5	-0.9	1.3
Mother’s age at death	3.1	3.9	7.4	-2.1	-2.7	2.4	-2.0	-1.0	-1.3	-2.1	-2.3	1.1	-2.1
Financial situation satisfaction	1.3	1.6	3.9	0.2	1.4	-1.2	2.0	1.9	0.1	1.1	0.9	-0.3	1.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.9	-0.9	-0.1	0.9	-0.2	0.0	0.5	0.1	-0.4	0.2	-0.4
Commuting to job workplace: Public transport	0.5	0.6	2.8	0.1	0.2	-0.8	0.0	-0.3	1.7	1.3	-0.2	0.9	-0.2
Eye problems/disorders: Glaucoma	3.3	3.9	8.1	-2.2	-2.8	0.7	-2.4	-2.5	-1.5	-1.6	-2.2	-0.2	-1.8
Medication: Blood pressure	1.4	2.6	5.0	1.6	2.0	-2.0	2.0	1.5	0.3	0.8	1.4	-1.2	2.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	-0.8	1.2	-1.0	0.6	0.3	-0.1	1.0	0.9	-1.3	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.6	-0.1	-0.6	-0.6	-0.6	-0.9	-0.3	-0.4	0.7	0.3
High cholesterol (Self-reported)	0.4	0.7	2.1	-0.2	-0.5	-0.7	0.9	1.3	-0.2	-1.4	-0.8	0.8	0.2
Medication: Bendroflumethiazide	1.7	2.6	6.3	2.5	1.9	-1.9	2.2	1.4	-0.8	0.6	1.5	-0.8	1.4
Medication: Paracetamol	2.6	4.0	12.2	0.4	3.5	-1.2	1.9	1.0	0.9	2.9	2.6	-1.5	1.7
Medication: Lisinopril	0.4	0.5	2.7	-0.5	-0.5	0.6	0.1	0.6	0.8	0.1	-0.6	1.6	0.5
Medication: Atorvastatin	0.3	0.3	1.8	-0.9	-0.0	0.3	0.3	0.5	0.3	-0.3	-0.4	1.3	-0.1
Illnesses of father: High blood pressure	1.9	2.4	5.3	1.2	2.1	-0.4	2.3	1.9	1.1	1.4	1.6	0.3	1.8
Alcohol drinker status: Never	0.9	1.1	2.9	1.7	1.3	-0.7	1.4	1.3	-0.3	-0.2	0.9	0.0	1.1
Ever smoked	0.3	0.5	2.1	-0.8	0.5	0.1	-1.0	-1.4	-0.7	-0.1	0.1	-0.7	-0.5
Basal metabolic rate	0.1	0.5	2.0	-0.2	0.9	0.2	0.9	1.0	-0.4	1.4	0.4	-0.3	0.2
Leg fat percentage (left)	0.2	0.7	1.7	0.8	0.9	-0.7	1.3	1.2	1.2	0.4	0.0	0.2	0.6
Arm fat-free mass (left)	0.1	0.5	2.6	-0.5	0.7	0.1	0.8	0.8	-0.6	1.6	0.3	-0.0	-0.0
Number of operations (self-reported)	0.2	0.3	1.3	-0.7	-0.0	0.3	-0.3	-0.1	-1.0	1.1	-0.2	-0.1	-0.5
Average weekly beer plus cider intake	0.6	0.8	3.5	-0.4	0.2	-0.2	1.6	1.9	0.5	-1.0	0.5	-0.4	0.7
Irritability	0.2	0.3	1.6	-0.3	0.0	-1.0	-0.5	-0.3	0.1	0.0	-0.3	-1.3	-0.1
Risk taking	0.3	0.4	1.4	0.1	0.6	0.6	1.2	1.1	0.7	-0.3	0.6	0.0	0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.5	0.5	-0.7	-0.3	-0.7	-0.1	0.7	0.1	0.1	0.3
Fractured/broken bones in last 5 years	3.2	4.2	9.5	1.3	3.1	-2.0	2.5	2.2	-0.7	2.5	2.5	-0.3	1.7
Age started oral contraceptive pill	0.2	0.2	1.2	1.1	0.3	0.0	0.4	0.7	-0.7	-0.1	0.0	0.0	0.1
Diastolic blood pressure, automated reading	0.9	2.9	10.9	1.8	0.7	-1.0	1.7	2.1	3.3	-0.3	-0.2	2.5	-0.1
Ever depressed for a whole week	1.0	1.2	2.8	-1.3	-0.5	0.2	-1.1	-1.7	1.5	-0.3	-0.8	-1.3	-1.1
Unable to work because of sickness or disability	0.6	0.8	3.0	1.0	-0.0	-1.0	0.7	0.6	0.9	1.7	-0.2	0.8	0.8
Commuting to job workplace: Cycle	2.0	2.4	6.7	-0.8	0.1	-1.1	-1.7	-2.6	-2.4	0.3	0.6	-2.4	-0.7
Myopia	0.7	1.0	2.7	-0.4	0.6	-1.4	-1.4	-1.6	-0.6	1.1	0.8	-0.7	-0.5
Vascular/heart problems diagnosed by doctor	2.1	5.7	13.9	-3.3	-2.0	1.8	-3.7	-3.7	-0.9	-0.7	-1.3	0.2	-2.8
Cholesterol lowering medication	1.5	2.2	7.1	1.3	1.4	-0.7	2.2	2.7	0.4	0.2	1.0	0.1	2.2
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.9	1.3	2.0	-1.7	1.4	0.7	-1.5	1.4	1.6	-0.6	0.9
Pain experienced in last month	1.3	2.2	5.9	1.0	-2.4	-0.1	-2.4	-1.7	-1.2	-1.4	-1.1	0.5	-1.4
Supplements: Calcium	0.7	0.8	2.3	0.7	0.6	-0.2	0.0	0.0	-1.0	1.5	1.1	-1.4	-0.4
Basal cell carcinoma (self-reported)	1.0	1.2	3.0	-0.0	-0.8	1.2	-0.2	0.9	1.6	-1.7	-0.9	1.1	-1.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.9	-0.1	-0.5	2.0	-0.2	0.4	0.4	-0.8	-1.4	1.2	-1.1
Deep venous thrombosis (DVT) (self-reported)	4.6	5.9	10.8	-2.5	-2.7	2.1	-2.8	-2.6	1.1	-2.5	-3.3	1.6	-2.5
Heart disease (siblings)	0.5	0.7	2.2	-0.0	-0.3	1.5	-0.2	0.2	0.4	-1.2	-0.7	1.2	-0.7
Alcohol drinker status: Previous	1.7	1.9	6.3	0.5	2.5	-1.4	1.4	1.0	-0.8	1.5	1.9	-0.4	1.0
Pack years of smoking	0.5	0.7	1.7	1.3	1.0	-0.1	1.2	1.1	-0.1	0.5	0.9	-0.7	-0.5
Impedance of whole body	0.5	2.7	6.5	0.0	2.4	-0.8	0.3	-0.9	-1.4	2.0	2.5	-2.2	1.5
Leg fat mass (left)	0.1	0.4	1.1	0.3	0.8	-0.4	1.1	1.0	0.6	0.7	-0.1	-0.1	0.1
Arm predicted mass (left)	0.1	0.6	2.3	-0.1	0.9	0.0	1.1	1.2	-0.7	1.5	0.4	0.0	0.1