Hub : Genes

C10orf58

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0159	0.0062	0.00052	0.009	0.006	0.001	0.006	0.006	5.6e-04	0.00270	1.8e-01	0.0047	3.2e-03
2	TCGA	Breast Invasive Carcinoma	0.0173	0.0097	0.00035	0.028	0.016	0.023	NA	0.023	1.5e-06	0.00025	1.1e-05	NA	1.1e-05
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0311	0.0230	0.00550	0.005	0.009	-0.002	NA	0.006	7.4e-02	0.02900	6.9e-01	NA	6.4e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0444	0.0271	0.00150	0.014	0.015	0.004	NA	0.008	9.2e-03	0.00690	1.0e-01	NA	4.2e-02
5	TCGA	Thyroid Carcinoma	0.0670	0.0410	0.00041	0.004	0.032	0.017	NA	0.001	1.3e-01	0.00039	7.4e-03	NA	2.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	1.1	1.0	-1.0	-0.3	0.7	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.3	3.1	0.6	-0.2	-1.3	1.7	1.2
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.2	-0.4
Depression (Nagel 2018)	0.4	0.5	1.5	-0.2	-0.4	-0.1	-1.0	-1.2
Intelligence (Savage-Jansen 2018)	2.1	6.4	10.9	-3.3	3.0	2.9	1.0	1.5
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.0	-0.3	-0.2	-0.3	-0.3
Schizophrenia (2018)	0.8	1.7	3.2	-0.1	0.5	-1.5	1.7	1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.3	-1.5	1.2	-0.1	0.4	0.7
Worry (Nagel 2018)	0.0	0.1	0.3	-0.6	-0.0	-0.3	0.0	0.1
Alzheimer’s Disease (in mother)	2.0	2.4	7.2	2.7	-0.9	-1.7	-0.6	-0.7
Alzheimer’s Disease (in father)	1.8	2.0	2.2	1.4	-1.4	-1.5	-1.2	-1.5
Alzheimer’s Disease (including proxy)	4.0	5.8	13.7	3.7	-1.8	-3.1	-0.9	-1.3
Crohns Disease (2017)	2.6	5.6	14.3	3.4	-1.3	-3.8	0.5	0.8
Irritable Bowel Disease (IBD)	2.2	5.1	12.2	3.3	-1.7	-3.5	0.0	0.3
Ulcerative Colitis (UC)	0.8	1.5	2.8	1.7	-1.3	-1.6	-0.4	-0.3
Major Depression (MDD)	1.6	1.9	2.9	1.4	-1.1	-0.9	-1.7	-1.6
Reaction Time	0.7	1.3	3.1	-0.6	0.7	0.9	1.8	1.3
Verbal and Numeric Reasoning (VNR)	1.6	3.8	7.3	-2.3	2.2	2.7	0.7	1.0
Breast Cancer	0.3	0.7	0.9	-0.7	0.9	0.7	0.9	0.9
Ovarian Cancer	0.4	0.5	1.5	-0.6	-0.3	0.3	-1.2	-0.6
Prostate Cancer	0.3	0.5	1.5	0.7	0.3	-1.2	0.2	0.5
Age at First Birth	3.9	5.7	9.9	2.6	-2.6	-3.2	-1.5	-1.7
Bipolar Disorder (2011)	0.7	0.7	1.7	0.8	-0.2	-0.7	1.3	0.9
Body Mass Index (BMI) (2010)	0.6	0.8	1.9	-1.1	0.8	1.4	0.3	0.3
Coronary Artery Disease (CAD)	3.6	4.3	10.0	-2.8	0.6	3.2	-1.2	-1.2
Crohns Disease (2012)	1.6	2.6	5.7	2.3	-1.0	-2.4	0.5	0.7
Mean Putamen Volume	0.2	0.2	0.8	0.4	0.9	0.0	-0.0	0.1
Fasting Glucose	0.2	0.2	0.7	-0.2	-0.2	-0.4	0.8	0.3
HbA1C	0.7	0.7	1.6	-0.8	1.0	0.3	0.6	1.3
HDL Cholesterol	1.1	1.9	2.9	1.7	-1.2	-1.2	-1.4	-1.3
LDL Cholesterol	2.7	4.3	5.8	1.6	-2.0	-2.2	-2.4	-2.2
Lupus	0.1	0.1	0.2	0.2	-0.4	-0.4	0.3	0.3
Neuroticism (2016)	0.3	0.4	1.0	-0.2	-1.0	-0.1	-0.3	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.3	-0.1	0.8	-0.9	-0.8
Rheumatoid Arthritis	7.8	10.8	19.2	-4.4	3.2	4.2	2.0	1.7
Schizophrenia (2014)	0.6	1.3	3.1	0.3	0.3	-1.8	1.2	1.3
Triglycerides	0.0	0.0	0.1	-0.4	-0.1	-0.2	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.3	-1.1	1.0	-0.5	0.9	1.5
Ulcerative Colitis	0.5	0.8	1.3	1.0	-1.1	-1.1	-0.6	-0.5
Blood Eosinophil Count	0.2	1.3	3.2	1.0	-1.2	-1.8	-0.6	-0.6
Blood Platelet Count	1.0	12.1	18.4	-3.2	3.0	2.7	4.0	4.3
Blood Red Count	0.5	4.5	12.6	-1.5	0.0	1.1	-3.5	-2.6
Blood White Count	2.0	14.8	23.0	4.8	-3.9	-4.3	-3.2	-2.7
Heel T-Score	4.2	33.2	39.1	4.8	-6.1	-6.2	-6.1	-5.5
BMI	0.2	1.1	2.3	-0.3	-0.2	0.9	-1.5	-1.5
Height	0.3	5.9	14.2	-0.5	2.2	1.0	3.8	3.0
Waist Hip Ratio (WHR)	0.8	3.7	10.0	-2.0	1.7	3.2	0.9	0.7
Systolic Blood Pressure	4.4	22.2	31.4	-4.7	4.8	5.6	4.3	4.1
Smoking Status	0.1	0.1	0.4	0.1	0.7	0.4	-0.1	0.1
Allergy or Eczema	0.4	1.1	2.0	-0.7	0.3	1.4	1.4	0.9
Cardiovascular Disease	1.1	3.7	11.8	-2.1	1.5	3.4	0.4	-0.1
Hypothyroidism (self reported)	0.1	0.3	0.9	-1.0	0.5	-0.3	0.4	0.2
Respiratory disease	4.3	9.6	17.1	-3.9	3.5	4.1	1.2	1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.4	0.0	-0.9	0.5	0.7
Lung FEV1/FVC ratio	14.5	73.3	93.5	7.8	-9.7	-8.6	-8.3	-8.2
Lung FVC	0.2	1.2	2.4	-1.2	1.6	0.9	0.7	0.8
Neuroticism	0.2	0.6	1.5	-1.2	0.5	0.7	0.6	0.6
Chronotype (morning person)	1.3	3.1	4.4	-1.2	1.5	1.9	1.9	2.1
Hair Pigment	0.1	3.9	8.8	2.1	-1.9	-3.0	-1.2	-1.2
Tanning	1.2	15.0	20.6	-3.5	4.5	4.3	3.0	3.8
Hand grip strength (left)	0.8	2.2	4.3	-2.1	1.7	1.5	0.4	1.1
Number of treatments/medications taken	3.8	6.9	8.3	-2.9	2.3	2.7	2.7	2.4
Average weekly spirits intake	0.3	0.4	0.7	0.8	-0.1	0.6	-0.8	-0.6
Sensitivity / hurt feelings	0.2	0.4	1.1	1.1	0.1	-0.8	0.5	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	-1.3	0.6	1.2	0.8	0.4
Hearing difficulty/problems: Yes	1.6	2.5	7.3	-1.6	0.8	2.7	1.2	0.7
Relative age of first facial hair	0.8	1.7	2.7	-1.3	1.6	1.0	1.3	1.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.6	-2.1	0.8	1.9	0.1	0.4
Ever used hormone-replacement therapy (HRT)	3.5	4.4	6.5	-1.5	2.5	2.2	2.1	2.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.1	0.4	1.1	0.4	1.3	1.4
Systolic blood pressure, automated reading	2.5	7.3	12.3	-2.2	2.3	3.5	2.9	2.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.3	-0.9	1.1	0.7	1.6	1.8
Angina	1.4	1.9	5.3	0.3	-0.9	0.2	-2.3	-1.8
Medication for hormone replacement therapy	0.1	0.1	0.3	0.5	0.2	-0.2	-0.3	0.0
Vitamin and mineral supplements	0.9	1.2	3.9	-0.5	0.1	0.4	-2.0	-1.3
Supplements: Zinc	1.3	1.4	3.6	-0.4	0.6	0.4	1.9	1.7
Medication: Co-codamol	2.4	2.8	3.3	-1.8	1.3	1.6	1.7	1.8
Medication: Metformin	0.9	1.3	2.8	-0.2	0.6	-0.8	1.6	1.7
Diabetes (father)	1.4	1.8	3.2	-1.1	1.2	0.5	1.7	1.8
Diabetes (mother)	3.1	4.0	7.7	0.1	-2.4	-0.5	-2.5	-2.8
Severe depression (siblings)	1.1	1.3	2.8	1.0	-0.0	-0.8	-1.7	-1.4
Pack years adult smoking proportion	0.9	1.3	3.7	-1.3	1.1	1.9	0.1	0.2
Impedance of leg (right)	0.7	3.3	7.5	-1.1	1.4	1.0	2.7	2.2
Leg fat-free mass (left)	0.1	0.5	0.9	-0.9	1.0	0.7	0.4	0.3
Trunk fat percentage	0.6	2.6	4.4	-1.8	1.5	2.1	1.3	1.0
Hand grip strength (right)	1.2	3.3	4.9	-2.2	1.8	2.2	1.2	1.5
Townsend deprivation index at recruitment	0.4	0.6	1.2	-1.1	0.8	1.1	0.1	0.1
Current tobacco smoking	0.4	0.6	1.9	-0.4	0.4	0.7	-1.4	-0.7
Average weekly fortified wine intake	0.3	0.4	1.0	-1.0	0.8	-0.0	0.2	0.4
Maternal smoking around birth	3.5	5.0	11.2	-2.5	2.4	3.4	0.7	1.2
Fed-up feelings	0.1	0.2	0.4	-0.5	0.2	0.3	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	-0.2	-0.5	-0.5	-0.8	-0.8
Relative age voice broke	0.9	1.4	2.2	-1.3	1.4	1.5	0.8	0.8
Taking other prescription medications	1.3	2.0	4.0	-2.0	0.9	1.6	1.2	1.0
Age when periods started (menarche)	2.1	5.0	7.2	2.2	-2.5	-2.7	-1.8	-1.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.9	-0.3	0.3	0.7	-0.9	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	6.7	15.2	21.3	3.5	-3.7	-3.2	-4.6	-4.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.4	-0.3	-0.3	1.2	-0.5	-0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.7	-0.2	-0.5	0.4	-1.3	-0.8
Serious illness, injury or assault to yourself	1.0	1.2	2.5	-1.3	1.6	0.9	0.7	0.7
High blood pressure	1.1	3.1	10.6	-1.9	1.2	3.2	-0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.5	-0.4	0.2	1.2	0.9	0.4
Multivitamins +/- minerals	1.4	1.7	4.8	0.5	0.6	-0.5	2.2	1.8
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.4	0.1	0.3	-0.3
Supplements: Glucosamine	1.0	1.4	4.6	0.4	-0.0	-0.5	2.1	1.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	0.9	-0.2	-0.1	-0.7	-0.4
Medication: Atenolol	0.4	0.5	1.2	0.2	-1.1	0.4	-0.3	-1.0
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.8	0.9	-0.1	-0.0	0.0
Sitting height	0.2	1.8	3.1	1.4	-0.8	-1.2	-1.3	-1.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.1	0.6	0.4	1.1	1.3
High blood pressure (mother)	0.7	1.0	2.8	-1.7	0.4	1.2	0.6	0.6
Body mass index (BMI)	0.1	0.5	1.0	-0.2	-0.1	0.8	-1.0	-1.0
Impedance of leg (left)	0.6	2.7	6.0	-0.8	1.4	0.9	2.4	2.1
Leg predicted mass (left)	0.1	0.5	1.0	-0.9	1.0	0.8	0.3	0.3
Trunk fat mass	0.5	2.0	3.9	-1.6	1.5	2.0	1.1	0.8
Waist circumference	0.5	1.7	4.9	-1.6	1.1	2.2	0.4	0.0
Number of incorrect matches in round	7.0	11.7	16.2	4.0	-3.9	-4.0	-2.0	-2.6
Past tobacco smoking	0.4	0.7	2.3	-0.7	0.0	0.2	-1.5	-0.9
Alcohol usually taken with meals	0.4	0.7	1.5	0.9	-0.8	-1.2	-0.7	-0.3
Nervous feelings	1.2	2.3	5.0	1.5	-1.7	-2.2	-0.7	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.3	-0.5
Hearing difficulty/problems with background noise	0.8	1.3	2.6	-1.6	-0.5	1.6	-0.5	-0.9
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.1	-0.1	0.2	0.5	0.0
Had menopause	1.3	1.6	3.0	-1.0	1.7	0.9	1.4	1.0
Had other major operations	0.0	0.0	0.1	0.1	-0.2	-0.3	0.3	0.2
Forced vital capacity (FVC)	1.3	5.0	7.2	-2.2	2.2	1.4	2.5	2.7
Heel bone mineral density (BMD) T-score, automated (right)	4.9	11.2	15.1	3.0	-3.3	-2.9	-3.9	-3.5
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.8	1.9	-1.2	-1.3	-1.3	-1.4
Qualifications: None of the above	0.4	0.9	1.5	-0.9	1.1	1.2	0.8	0.7
Financial difficulties in last 2 years	0.7	0.9	1.9	-0.3	0.6	1.4	1.2	0.8
Mouth/teeth dental problems	1.4	2.1	2.9	1.5	-1.4	-1.7	-1.3	-1.4
Heart attack	1.1	1.4	3.5	0.6	-0.8	0.3	-1.6	-1.9
Allergy	0.4	0.9	3.3	0.8	-0.7	-1.8	0.0	0.1
Pain all over the body in last month	0.2	0.2	0.3	-0.5	0.5	-0.3	0.4	0.6
Diabetes (self-reported)	0.3	0.4	0.7	-0.6	0.8	-0.6	0.3	0.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.1	-1.4	1.1	1.3	1.2	1.1
Medication: Ramipril	0.8	1.1	2.5	-1.3	0.9	1.6	0.5	0.4
Medication: Simvastatin	0.9	1.4	4.7	-1.0	0.4	2.2	-0.5	-0.8
Fluid intelligence score	0.8	1.6	2.7	-1.2	1.6	1.5	0.9	1.1
Illnesses of siblings	1.5	2.0	6.2	1.6	-0.8	-2.5	-0.8	-0.5
Neuroticism score	0.0	0.0	0.1	0.0	-0.2	-0.2	0.0	-0.1
Weight	0.3	1.2	2.3	-1.1	1.3	1.5	0.8	0.5
Impedance of arm (right)	1.1	5.3	9.4	-2.1	1.6	1.6	3.1	2.7
Arm fat percentage (right)	0.2	0.9	2.9	-1.2	0.5	1.7	0.3	0.0
Trunk fat-free mass	0.1	0.5	1.6	-0.1	1.2	0.8	0.6	0.4
Hip circumference	0.2	0.9	1.7	-0.8	1.3	1.2	0.7	0.5
Time employed in main current job	2.3	2.7	3.6	1.1	-1.9	-1.3	-1.8	-1.9
Alcohol intake versus 10 years previously	1.2	1.8	3.6	-0.7	1.4	0.7	1.9	1.6
Father’s age at death	0.7	1.0	2.8	1.4	-0.3	-1.7	-0.3	-0.1
Worrier / anxious feelings	0.1	0.3	0.7	-0.2	0.4	0.2	0.8	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.9	-1.4	0.7	0.7	0.2	0.0
Falls in the last year	1.7	2.3	5.4	-1.3	1.8	2.3	0.7	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.2	-0.4	-0.2	-0.3	-0.4
Number of live births	0.4	0.6	2.2	-0.4	1.5	0.4	0.4	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.5	0.3	-0.6	-1.2	0.2	0.5
Pulse rate	0.4	0.7	1.7	1.3	-0.2	-0.6	-1.0	-0.7
Happiness	1.5	1.9	4.1	1.0	-1.2	-0.5	-1.6	-2.0
Noisy workplace	1.3	1.6	2.1	1.4	-1.3	-0.9	-1.2	-1.4
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.6	-0.5	0.9	-0.5	1.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	-1.2	1.3	0.1	-0.7	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	0.6	-0.1	-0.8	0.9	0.6
Asthma	2.6	5.2	12.1	-2.8	2.4	3.5	0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	4.8	-2.1	2.2	1.8	2.0	1.8
Medication: Cholesterol lowering	0.2	0.3	0.6	0.3	-0.5	0.7	-0.5	-0.8
Depression (self-reported)	0.5	0.6	1.5	0.6	0.3	-0.2	-1.2	-1.1
Medication: Lansoprazole	0.4	0.4	1.2	-1.1	-0.2	0.5	-0.6	-0.6
Prospective memory result	4.4	5.4	7.3	2.5	-2.6	-2.7	-1.5	-2.1
Lung cancer (father)	1.2	1.4	2.6	0.7	1.1	-0.4	1.6	1.6
Illnesses of mother	1.2	1.5	3.0	-0.2	1.7	-0.4	1.3	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.5	0.9	-0.9	-1.6	-0.1	0.0
Pulse wave Arterial Stiffness index	0.4	0.5	2.1	0.0	0.2	1.5	0.4	0.1
Impedance of arm (left)	1.1	4.9	10.9	-1.6	1.6	1.1	3.3	2.7
Arm fat mass (right)	0.2	1.0	2.7	-1.1	1.0	1.6	0.3	0.1
Trunk predicted mass	0.1	0.6	1.7	-0.2	1.3	0.8	0.6	0.4
Standing height	0.9	9.2	15.8	-1.9	3.4	1.7	4.0	3.5
Length of working week for main job	1.1	1.2	2.4	1.5	-1.1	-1.5	-0.2	-0.2
Exposure to tobacco smoke at home	1.3	1.4	3.3	-1.7	0.4	1.8	0.8	0.5
Breastfed as a baby	2.0	2.5	4.8	1.2	-1.5	-0.8	-1.8	-2.2
Tense / ‘highly strung’	0.0	0.1	0.2	0.2	0.1	-0.4	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	-0.5	0.8	0.2	-1.3	-0.8
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	-0.0	0.1	-0.6	-0.5
Birth weight of first child	4.9	8.9	19.6	4.4	-2.9	-3.6	-1.4	-1.3
Peak expiratory flow (PEF)	0.9	2.2	5.1	1.6	-1.7	-2.3	-0.4	-0.2
Pulse wave reflection index	0.4	0.5	1.0	-0.4	-0.5	1.0	-0.5	-0.7
Ever highly irritable/argumentative for 2 days	1.3	1.5	3.4	0.0	-1.0	0.3	-1.8	-1.8
Loud music exposure frequency	0.4	0.4	0.7	0.7	-0.3	-0.8	-0.7	-0.4
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	6.6	-1.9	2.6	1.3	1.9	2.3
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	-1.1	0.4	1.2	-1.6	-1.1
Blood clot in the leg (DVT)	4.9	6.3	7.7	2.8	-2.3	-2.6	-2.5	-2.4
Medication: Paracetamol	2.7	4.5	6.4	-2.2	1.9	1.9	2.5	2.0
Headache pain in last month	2.8	4.8	10.5	-3.2	1.8	2.8	1.3	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	-0.1	0.1	-1.1	0.1	0.5
Glaucoma (self-reported)	1.5	1.7	4.1	2.0	-0.8	-1.8	0.3	0.6
Gout (self-reported)	0.9	1.3	2.3	-0.0	-1.5	-1.5	-0.9	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	-0.2	-0.2	-1.4	-0.1	-0.1
Medication: Amlodipine	1.6	2.3	7.0	-1.9	0.7	2.6	0.5	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.7	-1.5	1.0	1.9	0.0	0.1
Birth weight	3.9	8.5	11.2	3.3	-2.7	-3.1	-2.8	-2.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	-0.3	-1.1	0.5	-0.2	-0.3
High blood pressure (siblings)	1.3	1.9	5.4	-1.6	0.8	2.3	0.7	0.5
Forced vital capacity (FVC), Best measure	0.7	2.5	3.2	-1.4	1.8	1.0	1.8	1.8
Body fat percentage	0.4	1.8	3.2	-1.5	1.3	1.8	1.0	0.8
Leg fat percentage (right)	0.1	0.4	1.2	-0.7	0.2	1.1	0.3	0.0
Arm fat-free mass (right)	0.1	0.3	1.2	-0.0	1.1	0.4	0.0	-0.1
Exposure to tobacco smoke outside home	4.2	5.6	7.8	-2.2	2.1	2.8	2.3	2.4
Comparative body size at age 10	0.9	2.5	3.5	1.4	-1.8	-0.9	-1.9	-1.8
Number of full brothers	1.3	1.6	2.4	-1.1	1.2	1.6	1.5	1.0
Worry too long after embarrassment	0.1	0.1	0.2	-0.2	0.5	0.1	0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	-0.1	-0.0	-0.5	-0.6
Wheeze or whistling in the chest in last year	0.7	1.3	3.3	-0.9	1.4	1.8	-0.4	-0.2
Number of children fathered	0.3	0.3	1.3	1.1	-0.6	-0.2	-0.0	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	4.0	0.5	-1.8	-1.2	-2.0	-1.8
Age at first live birth	0.2	0.4	1.0	1.0	-0.3	-0.9	0.3	0.1
Pulse wave peak to peak time	0.3	0.3	1.6	-0.1	-0.0	-1.3	-0.2	0.1
Health satisfaction	1.0	1.3	3.8	-1.4	0.5	1.9	-0.5	-0.6
Shortness of breath walking on level ground	0.4	0.5	1.0	0.1	1.0	0.6	0.8	0.7
Qualifications: College or University degree	0.1	0.4	1.6	0.8	0.2	-1.3	0.1	0.2
Eye problems/disorders: None of the above	1.0	1.2	3.6	0.2	0.4	-0.5	1.9	1.3
Mouth/teeth dental problems: Loose teeth	2.9	3.4	4.6	-1.8	2.1	1.1	1.9	2.1
Emphysema/chronic bronchitis	1.5	1.7	3.5	-1.2	1.2	1.9	1.1	1.1
Medication for pain relief, constipation, heartburn	3.6	6.1	7.8	2.8	-2.7	-2.3	-2.2	-2.2
Neck or shoulder pain in last month	0.3	0.5	1.7	0.1	0.3	0.3	1.3	0.6
Medication: Blood pressure	0.4	0.8	3.6	-0.0	-0.1	1.9	0.1	-0.6
Angina (self-reported)	1.4	1.8	5.5	-0.1	-0.6	0.5	-2.4	-1.7
Migraine (self-reported)	1.7	2.2	3.6	-1.9	1.4	1.4	1.4	1.1
Medication: Ibuprofen	3.2	3.9	4.9	-2.0	2.0	1.7	2.2	1.9
Medication: Allopurinol	0.7	0.9	2.0	0.3	-1.4	-1.2	-0.6	-0.9
Medication: Omeprazole	0.9	1.1	2.3	-1.0	0.0	0.9	1.5	1.1
Medication: Seretide 50 evohaler	1.2	1.4	3.9	-1.5	0.6	2.0	0.3	0.5
Mean time to correctly identify matches	0.8	1.5	3.6	-0.7	1.0	1.0	1.9	1.2
Heart disease (mother)	1.8	2.3	6.4	0.3	-1.1	-0.2	-2.5	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.6	0.8	0.2	0.3	0.9
Whole body fat mass	0.3	1.4	2.8	-1.4	1.2	1.7	0.7	0.5
Leg fat mass (right)	0.1	0.3	0.8	-0.6	0.4	0.9	0.1	-0.2
Arm predicted mass (right)	0.1	0.7	2.4	-0.3	1.6	0.9	0.4	0.3
Pulse rate, automated reading	0.3	1.1	2.1	1.0	-1.0	-0.1	-1.5	-1.2
Alcohol intake frequency.	3.2	7.3	10.2	-3.1	2.7	3.2	2.2	2.3
Comparative height size at age 10	0.7	3.6	4.6	-1.9	1.9	1.9	2.1	1.8
Number of full sisters	0.6	0.7	1.6	0.5	0.2	0.6	-1.1	-1.3
Suffer from ‘nerves’	0.5	0.8	2.0	-1.4	1.1	0.8	-0.5	0.1
Overall health rating	4.8	10.2	16.0	-3.8	3.4	4.0	2.3	2.0
Chest pain or discomfort	0.8	1.2	1.8	-1.4	1.3	1.3	0.5	0.7
Had major operations	0.3	0.4	0.9	1.0	-0.5	-0.9	0.3	0.0
Age at last live birth	1.5	2.2	6.4	1.9	-0.8	-2.5	0.2	0.5
Family relationship satisfaction	1.1	1.4	2.9	0.7	-1.4	0.3	-1.2	-1.7
Leg pain on walking	0.2	0.2	0.6	0.2	0.7	0.6	0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	5.9	2.4	-2.4	-2.0	-0.4	-0.7
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.4	1.4	-2.3	-1.0	-1.7	-2.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	-0.7	0.1	0.4	0.5	0.9
Medication: Aspirin	0.9	1.2	2.7	-0.9	1.3	1.6	-0.8	-0.4
Supplements: Vitamin C	0.7	0.9	1.8	1.1	-1.4	-0.7	-0.4	-0.9
Knee pain experienced in last month	5.3	8.3	18.0	-3.6	2.2	4.2	1.9	1.5
Hypertension (Self-reported)	1.1	3.2	10.4	-1.8	1.4	3.2	0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	-0.4	-1.1	-0.5	-0.7	-0.8
Illnesses of father: Heart disease	1.5	2.0	3.8	-1.4	-0.6	2.0	-1.4	-1.5
Illnesses of siblings: Diabetes	1.0	1.3	2.6	-0.6	1.1	0.8	1.6	1.2
Smoking status: Previous	0.8	1.2	3.4	1.0	-0.2	-0.4	1.9	1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	6.1	-2.5	1.3	1.6	0.5	0.5
Whole body fat-free mass	0.1	0.5	1.3	-0.3	1.1	0.8	0.5	0.3
Leg fat-free mass (right)	0.1	0.3	0.7	-0.6	0.9	0.6	0.1	0.1
Arm fat percentage (left)	0.2	0.6	2.0	-1.0	0.4	1.4	0.2	-0.1
Average weekly red wine intake	0.7	1.0	1.6	0.5	-1.1	-1.3	-1.0	-1.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.1	-0.4	-0.4	0.1	0.4
Mood swings	0.2	0.4	0.5	0.6	-0.7	-0.5	-0.7	-0.6
Loneliness, isolation	1.8	2.5	5.4	-0.2	1.6	1.0	2.3	1.9
Long-standing illness, disability or infirmity	0.9	1.4	2.3	-1.2	1.0	1.5	1.0	1.1
Ever had bowel cancer screening	7.4	8.7	15.1	3.2	-2.8	-3.9	-2.1	-2.4
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.2	0.7	-0.5	-0.0	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.6	1.2	0.7	-0.4	1.6	1.3
Friendships satisfaction	0.6	0.8	1.8	-1.3	0.6	1.1	0.5	0.7
Qualifications: nursing, teaching	0.3	0.5	1.6	0.1	-0.3	-1.2	0.8	0.5
Commuting to job workplace: Walk	2.5	2.7	3.8	-1.3	1.9	1.2	1.7	1.9
Eye problems/disorders: Cataract	1.5	1.8	2.6	-1.4	0.3	1.6	-1.6	-1.3
Mouth/teeth dental problems: Mouth ulcers	5.2	8.3	10.6	-3.0	2.9	3.3	2.7	2.6
Medication for cholesterol	0.8	1.2	3.2	1.4	-0.6	-1.8	0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.8	0.5	-1.3	-0.3	-0.5	-1.1
Back pain experienced in last month	1.2	1.7	2.7	1.6	-1.5	-0.6	-1.1	-1.6
Mineral and other dietary supplements	0.7	1.0	3.0	-0.2	0.2	0.8	-1.7	-1.1
Breast cancer (self-reported)	0.7	0.9	2.8	0.2	-0.7	0.5	-0.9	-1.7
Asthma (self-reported)	3.9	7.7	16.4	-3.4	2.9	4.1	0.9	1.0
Osteoporosis (self-reported)	1.3	1.6	3.2	-1.7	1.8	1.0	0.1	0.9
Osteoarthritis (self-reported)	0.5	0.7	2.3	-1.5	0.4	1.0	0.2	0.0
Medication: Aspirin	0.9	1.1	1.8	-0.7	1.0	1.4	-1.3	-0.8
Medication: Gliclazide	0.4	0.4	1.2	0.4	-0.9	-1.1	-0.3	0.0
Illnesses of father: None of the above (group 1)	0.8	1.0	3.4	0.9	-1.0	-1.9	0.1	-0.1
Smoking status: Current	0.4	0.7	1.9	-0.5	0.3	0.6	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.6	1.0	-1.1	-1.3	-1.1	-0.9
Whole body water mass	0.1	0.5	1.4	-0.4	1.2	0.8	0.4	0.3
Leg predicted mass (right)	0.1	0.3	0.7	-0.6	0.8	0.7	-0.0	-0.0
Arm fat mass (left)	0.2	0.9	2.6	-1.1	0.9	1.6	0.3	0.0
Number of self-reported non-cancer illnesses	1.1	2.0	4.0	-1.8	0.9	2.0	-0.9	-1.0
Average weekly champagne plus white wine intake	0.4	0.5	1.2	0.6	0.2	-0.4	0.9	1.1
Miserableness	0.5	0.8	1.9	-1.3	0.6	1.4	0.3	0.1
Guilty feelings	1.4	2.2	5.2	0.3	-1.3	0.2	-1.9	-2.3
Wears glasses or contact lenses	0.8	0.9	2.4	0.8	-0.5	-1.6	-0.7	-0.9
Ever taken oral contraceptive pill	0.3	0.3	0.7	-0.8	0.5	0.7	-0.3	-0.3
Hearing aid user	2.5	2.9	6.5	-2.5	1.2	2.3	0.8	0.7
Mother’s age at death	4.3	5.4	6.1	2.5	-2.3	-2.3	-2.1	-2.4
Financial situation satisfaction	0.9	1.2	3.0	-1.2	1.1	1.7	0.6	0.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.8	0.9	-0.2	-0.1	0.1	-0.5
Commuting to job workplace: Public transport	0.3	0.4	1.9	0.1	1.4	0.0	-0.2	0.3
Eye problems/disorders: Glaucoma	2.9	3.5	7.1	2.7	-1.7	-2.6	-0.6	-0.3
Medication: Blood pressure	1.2	2.2	4.8	-2.2	1.2	2.2	0.3	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.8	0.6	0.7	0.9	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.2	-0.5	-0.8	0.5	0.1
High cholesterol (Self-reported)	0.7	1.2	2.2	0.9	-1.4	0.3	-0.9	-1.5
Medication: Bendroflumethiazide	1.4	2.1	4.6	-1.9	0.9	2.1	1.0	0.6
Medication: Paracetamol	3.7	5.7	7.1	-2.3	2.4	2.3	2.7	2.1
Medication: Lisinopril	0.1	0.1	0.2	-0.2	0.4	0.4	-0.4	0.1
Medication: Atorvastatin	0.3	0.4	0.8	-0.5	-0.1	0.6	-0.9	-0.7
Illnesses of father: High blood pressure	1.9	2.3	5.3	-1.3	1.4	2.3	1.4	0.9
Alcohol drinker status: Never	1.0	1.2	3.0	-1.7	0.2	1.7	-0.2	0.1
Ever smoked	0.3	0.5	1.0	0.8	-0.4	-0.6	1.0	0.5
Basal metabolic rate	0.1	0.6	1.5	-0.6	1.2	0.9	0.5	0.3
Leg fat percentage (left)	0.1	0.3	1.2	-0.6	0.3	1.1	0.1	0.0
Arm fat-free mass (left)	0.1	0.6	1.8	-0.5	1.4	0.8	0.4	0.3
Number of operations (self-reported)	0.2	0.3	1.1	0.1	1.1	0.2	-0.3	0.1
Average weekly beer plus cider intake	0.4	0.6	1.0	0.3	-0.8	1.0	-0.4	-0.9
Irritability	0.2	0.3	0.5	0.5	-0.2	-0.5	-0.7	-0.7
Risk taking	0.3	0.4	1.2	-0.2	-0.0	1.1	0.6	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.3	0.3	-0.4	1.2	0.8
Fractured/broken bones in last 5 years	4.6	5.9	11.0	-2.3	2.8	3.3	1.6	1.8
Age started oral contraceptive pill	0.1	0.1	0.3	-0.3	-0.3	0.4	-0.1	-0.5
Diastolic blood pressure, automated reading	0.5	1.5	4.4	-0.7	0.2	2.1	-1.1	-1.2
Ever depressed for a whole week	1.0	1.2	3.9	2.0	-0.4	-1.2	-0.3	-0.7
Unable to work because of sickness or disability	0.9	1.2	2.7	-1.5	1.6	0.6	-0.6	-0.2
Commuting to job workplace: Cycle	0.5	0.6	1.1	-0.4	0.1	-1.1	0.7	1.0
Myopia	0.6	0.9	1.5	0.0	0.9	-0.7	1.2	1.2
Vascular/heart problems diagnosed by doctor	1.6	4.2	12.7	2.5	-1.2	-3.6	0.6	0.8
Cholesterol lowering medication	1.6	2.4	5.9	-2.1	0.6	2.4	-0.7	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	5.8	-1.4	1.2	1.3	2.4	2.2
Pain experienced in last month	1.0	1.7	5.4	1.2	-1.1	-2.3	-0.8	-0.0
Supplements: Calcium	1.4	1.6	3.0	-0.8	1.2	-0.0	1.7	1.7
Basal cell carcinoma (self-reported)	2.1	2.5	5.3	0.8	-1.4	-0.5	-2.0	-2.3
Heart attack/myocardial infarction (self-reported)	1.2	1.5	3.7	0.8	-0.9	0.2	-1.5	-1.9
Deep venous thrombosis (DVT) (self-reported)	5.6	7.3	8.5	2.9	-2.5	-2.8	-2.7	-2.5
Heart disease (siblings)	0.7	0.8	1.3	0.8	-1.1	-0.2	-0.9	-1.1
Alcohol drinker status: Previous	2.4	2.7	4.3	-0.9	1.4	1.9	2.1	1.8
Pack years of smoking	0.4	0.5	2.0	-0.6	0.6	1.4	0.1	-0.1
Impedance of whole body	1.0	4.9	10.4	-1.5	1.7	1.0	3.2	2.8
Leg fat mass (left)	0.1	0.3	0.8	-0.6	0.5	0.9	0.1	-0.1
Arm predicted mass (left)	0.1	0.7	1.7	-0.6	1.3	1.1	0.3	0.2