TWAS hub - DYDC2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1320	0.034	9.5e-09	0.132	0.086	0.112	0.120	0.124	9.2e-16	1.3e-10	1.5e-13	2.0e-14	7.9e-15
2	ROSMAP	Brain Pre-frontal Cortex	0.0772	0.024	1.2e-05	0.065	0.043	0.057	0.053	0.065	8.5e-09	2.7e-06	6.6e-08	2.1e-07	1.0e-08
3	TCGA	Liver Hepatocellular Carcinoma	0.1100	0.066	5.6e-03	0.020	0.014	0.056	NA	0.027	3.8e-02	6.9e-02	1.3e-03	NA	2.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Lung FEV1/FVC ratio	8.5	42.9	77.1	5.5	4.6	8.8
Heel bone mineral density (BMD) T-score, automated (left)	5.3	12.1	15.5	3.2	3.2	3.9
Multivitamins +/- minerals	4.8	6.1	8.2	-2.5	-2.9	-1.9
Systolic Blood Pressure	4.5	22.3	40.2	-4.4	-2.7	-6.3
Ever had stillbirth, spontaneous miscarriage or termination	4.5	4.8	6.5	-2.6	-2.4	-1.4
Mineral and other dietary supplements	4.5	6.0	7.8	2.8	2.8	1.6
Vitamin and mineral supplements	4.4	6.0	7.8	2.8	2.8	1.6
Diabetes (mother)	4.4	5.7	6.4	2.4	2.1	2.5
Supplements: Glucosamine	4.4	5.7	9.1	-2.5	-3.0	-1.3
Supplements: Zinc	4.3	4.7	5.3	-2.3	-2.3	-1.9
Time employed in main current job	3.9	4.5	5.5	2.0	2.0	2.3
Angina (self-reported)	3.9	5.1	6.6	2.5	2.6	1.6
Depression (self-reported)	3.8	4.5	5.7	2.4	1.5	2.4
Angina	3.6	4.7	5.7	2.3	2.4	1.7
Basal cell carcinoma (self-reported)	3.5	4.2	4.4	2.1	2.0	2.0
Ever highly irritable/argumentative for 2 days	3.3	4.0	4.5	2.1	1.9	2.0
Mother’s age at death	3.3	4.1	8.9	1.5	1.1	3.0
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.3	11.0	2.4	2.3	3.3
Smoking status: Previous	3.2	4.8	7.0	-2.4	-2.6	-1.4
Systolic blood pressure, automated reading	3.1	9.0	13.6	-3.0	-2.1	-3.7
Diabetes (father)	3.1	3.8	4.9	-1.9	-1.6	-2.2
Heel T-Score	3.0	24.0	40.3	4.5	3.4	6.3
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	4.1	-1.8	-1.9	-2.0
Heart disease (mother)	2.8	3.4	6.0	1.8	2.5	1.1
Eye problems/disorders: Cataract	2.8	3.3	4.9	2.2	2.0	1.0
Alcohol drinker status: Previous	2.8	3.2	4.8	-1.8	-1.2	-2.2
Chronic bronchitis/emphysema (father)	2.7	3.2	4.0	-1.8	-1.5	-2.0
Commuting to job workplace: Car/motor vehicle	2.7	3.1	5.2	1.6	1.2	2.3
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	9.2	-1.5	-1.1	-3.0
Happiness	2.6	3.1	4.0	1.5	1.7	2.0
Guilty feelings	2.5	3.8	4.4	1.9	2.1	1.8
Coronary Artery Disease (CAD)	2.4	2.8	5.8	1.6	2.4	0.3
Loneliness, isolation	2.3	3.2	3.3	-1.8	-1.8	-1.8
Ever had bowel cancer screening	2.3	2.6	7.6	0.5	-0.2	2.8
Commuting to job workplace: Cycle	2.3	2.7	3.7	-1.9	-1.8	-1.2
Schizophrenia (2018)	2.2	4.6	5.6	-2.4	-2.3	-1.7
Blood Red Count	2.2	20.9	27.6	5.2	5.1	3.1
Commuting to job workplace: Walk	2.2	2.3	4.2	-1.4	-1.0	-2.0
Fractured/broken bones in last 5 years	2.1	2.8	6.8	-1.2	-0.3	-2.6
Emphysema/chronic bronchitis	2.0	2.3	4.0	-1.5	-0.8	-2.0
Cholesterol lowering medication	2.0	2.9	3.8	2.0	1.8	1.3
Crohns Disease (2017)	1.9	4.3	6.6	-2.4	-2.6	-0.6
Medication: Metformin	1.9	2.7	3.6	-1.9	-1.5	-1.4
Medication: Ibuprofen	1.9	2.3	3.8	-1.2	-2.0	-1.3
Unable to work because of sickness or disability	1.9	2.4	3.9	2.0	1.1	1.5
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	3.6	-1.4	-0.7	-1.9
Past tobacco smoking	1.8	3.2	4.1	2.0	2.0	1.3
Mouth/teeth dental problems	1.8	2.8	5.7	1.5	0.7	2.4
Crohns Disease (2012)	1.7	2.7	4.0	-1.9	-2.0	-0.7
Glaucoma (self-reported)	1.7	2.0	3.8	-1.4	-1.9	-0.5
Impedance of leg (right)	1.6	7.7	8.7	-2.9	-2.7	-2.7
Number of incorrect matches in round	1.6	2.6	7.7	0.0	-0.1	2.8
Lung cancer (father)	1.6	1.9	2.5	-1.6	-1.5	-1.0
Blood clot in the leg (DVT)	1.6	2.0	4.1	1.1	0.9	2.0
Eye problems/disorders: None of the above	1.6	1.8	3.4	-1.3	-1.8	-0.5
Age at last live birth	1.6	2.3	3.9	-1.7	-2.0	-0.3
Impedance of whole body	1.6	8.1	8.5	-2.9	-2.8	-2.8
Reaction Time	1.5	2.8	3.8	-1.9	-1.3	-1.7
Number of treatments/medications taken	1.5	2.8	3.7	-1.4	-1.6	-1.9
Severe depression (siblings)	1.5	1.7	2.5	1.2	1.1	1.6
Current tobacco smoking	1.5	2.5	3.9	1.8	2.0	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.3	-1.0	-1.8	-1.2
Impedance of arm (left)	1.5	7.0	7.7	-2.8	-2.7	-2.5
Standing height	1.5	14.5	16.2	-4.0	-3.8	-3.5
Birth weight	1.5	3.2	7.5	1.4	0.4	2.7
Exposure to tobacco smoke outside home	1.5	2.1	5.0	-0.7	-0.8	-2.2
Neck or shoulder pain in last month	1.5	2.2	3.1	-1.8	-1.5	-1.0
Medication: Omeprazole	1.5	1.7	2.0	-1.4	-1.4	-1.2
Myopia	1.5	2.2	3.0	-1.7	-1.3	-1.4
Ovarian Cancer	1.4	1.8	2.5	1.6	1.6	0.6
Prostate Cancer	1.4	2.0	2.8	-1.7	-1.4	-1.1
Comparative body size at age 10	1.4	3.8	4.3	1.9	2.1	1.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.9	-1.0	-1.1	-1.7
Bipolar Disorder or Schizophrenia	1.3	3.3	5.6	-1.9	-2.4	-0.8
Major Depression (MDD)	1.3	1.6	2.4	0.9	1.6	1.2
LDL Cholesterol	1.3	2.0	4.1	1.1	0.9	2.0
Primary Biliary Cirrhosis	1.3	1.8	2.7	1.6	1.5	0.7
Rheumatoid Arthritis	1.3	1.7	4.9	-0.4	-0.3	-2.2
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.4	-0.9	-0.9	-1.8
Maternal smoking around birth	1.3	1.8	3.0	0.8	1.4	-1.7
Impedance of leg (left)	1.3	6.1	6.5	-2.6	-2.4	-2.4
Medication: Ramipril	1.3	1.6	2.7	-1.2	-0.8	-1.6
Impedance of arm (right)	1.3	6.1	6.8	-2.5	-2.3	-2.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.6	1.2	1.9	0.0
Medication: Paracetamol	1.3	2.2	2.6	-1.4	-1.6	-1.4
Illnesses of father: Heart disease	1.3	1.8	2.9	1.5	1.7	0.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.3	0.9	1.0	1.8
Medication: Co-codamol	1.2	1.4	3.0	-0.8	-0.7	-1.7
Prospective memory result	1.2	1.5	3.9	0.6	0.4	2.0
Migraine (self-reported)	1.2	1.5	1.8	-1.2	-1.3	-1.1
Medication: Aspirin	1.2	1.6	2.3	1.5	1.5	0.5
Smoking status: Current	1.2	2.0	3.2	1.5	1.8	0.6
Medication: Paracetamol	1.2	1.9	2.1	-1.2	-1.4	-1.4
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.4	-1.2	-1.6	-0.5
Blood Platelet Count	1.1	12.4	23.0	-3.2	-2.0	-4.8
Breastfed as a baby	1.1	1.4	2.1	0.9	1.0	1.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.7	-0.9	-0.9	-1.9
Illnesses of father: High blood pressure	1.1	1.3	2.2	-0.9	-0.9	-1.5
Depression (Nagel 2018)	1.0	1.5	2.5	1.4	0.4	1.6
Irritable Bowel Disease (IBD)	1.0	2.3	4.0	-2.0	-1.6	-0.6
Schizophrenia (2014)	1.0	2.3	4.5	-1.4	-2.1	-0.6
Chronotype (morning person)	1.0	2.4	5.6	-1.0	-0.7	-2.4
Qualifications: CSEs or equivalent	1.0	1.4	2.3	1.4	1.5	0.2
Pulse rate	1.0	1.7	2.2	1.4	1.0	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.9	1.1	1.7	0.7
Health satisfaction	1.0	1.3	1.6	1.3	1.2	1.0
Medication for pain relief, constipation, heartburn	1.0	1.7	2.6	1.0	1.2	1.6
Mean time to correctly identify matches	1.0	1.9	2.5	-1.6	-1.3	-1.3
Number of full sisters	1.0	1.2	1.6	1.2	1.3	0.8
Illnesses of siblings: Diabetes	1.0	1.2	1.6	-1.2	-1.2	-0.9
Number of self-reported non-cancer illnesses	1.0	1.7	2.4	1.4	1.6	0.9
Ever smoked	1.0	1.8	2.6	-1.5	-1.6	-0.8
Alzheimer’s Disease (in father)	0.9	1.0	2.4	0.5	0.5	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	2.0	1.3	0.4	1.4
Medication: Simvastatin	0.9	1.3	1.8	1.3	1.3	0.7
Family relationship satisfaction	0.9	1.1	2.4	0.7	1.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.0	1.5	0.8	1.7
Eye problems/disorders: Glaucoma	0.9	1.0	2.3	-0.7	-1.5	0.5
HbA1C	0.8	0.9	2.0	-0.4	-0.7	-1.4
Lupus	0.8	1.3	1.5	-1.2	-1.0	-1.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.1	-1.0	-0.7	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.7	0.6	0.9	1.3
Heart attack	0.8	1.1	1.6	1.0	0.8	1.3
Worrier / anxious feelings	0.8	1.4	1.8	-1.3	-0.9	-1.3
Illnesses of mother	0.8	1.0	1.7	-0.8	-1.3	-0.8
Number of children fathered	0.8	0.9	1.7	-1.3	-0.8	-0.7
Qualifications: nursing, teaching	0.8	1.2	2.6	-0.9	-1.6	0.4
Average weekly champagne plus white wine intake	0.8	1.1	1.3	-1.0	-1.0	-1.1
Medication: Blood pressure	0.8	1.4	3.5	-0.9	-0.1	-1.9
Supplements: Calcium	0.8	0.9	1.1	-1.1	-0.9	-0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.9	0.9	0.6	1.4
Bipolar Disorder (2011)	0.7	0.7	1.6	-0.7	-1.3	-0.1
BMI	0.7	3.8	5.2	2.3	1.7	1.8
Height	0.7	12.7	15.1	-3.9	-3.4	-3.4
Forced vital capacity (FVC)	0.7	2.7	3.8	-1.3	-1.6	-2.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	1.3	-0.9	-0.9	-1.2
Noisy workplace	0.7	0.9	1.4	0.8	0.8	1.2
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.7	-1.2	-1.7	-0.8
Medication: Lansoprazole	0.7	0.8	1.1	1.1	1.0	0.6
High blood pressure (siblings)	0.7	1.0	2.4	-0.7	-0.4	-1.5
Medication: Bendroflumethiazide	0.7	1.1	2.7	-0.6	-0.4	-1.6
Age at First Birth	0.6	0.9	2.1	-0.2	-0.8	1.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	0.8	1.1	0.2
Hearing difficulty/problems with background noise	0.6	0.9	1.8	0.9	1.3	0.3
Had other major operations	0.6	0.7	1.1	-1.0	-0.7	-0.8
Alcohol intake versus 10 years previously	0.6	0.8	2.5	-0.1	-1.6	0.0
Age at first live birth	0.6	1.0	1.8	-1.1	-1.3	-0.1
Comparative height size at age 10	0.6	3.4	3.9	-1.6	-1.9	-2.0
Had major operations	0.6	0.7	1.6	-0.8	-1.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.3	-0.8	-0.2	-1.1
Medication: Aspirin	0.6	0.8	1.6	0.9	1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.8	0.8	0.9	0.8
Fasting Glucose	0.5	0.6	1.4	-1.2	-0.2	-0.7
Allergy or Eczema	0.5	1.4	1.8	-1.3	-1.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	0.7	1.1	-0.6
Hand grip strength (right)	0.5	1.4	3.3	-0.8	-0.5	-1.8
Age when periods started (menarche)	0.5	1.1	3.3	0.2	-0.1	1.8
Body mass index (BMI)	0.5	2.0	2.7	1.6	1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.2	1.1	0.7	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	1.0	0.7	0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	-0.8	-1.3	-0.0
Exposure to tobacco smoke at home	0.5	0.6	1.1	-0.8	-0.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.4	-0.3	0.5	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.4	1.0	0.7
Pulse rate, automated reading	0.5	1.5	1.9	1.4	1.1	1.2
Alcohol intake frequency.	0.5	1.2	3.3	-0.4	-0.4	-1.8
Overall health rating	0.5	1.0	2.3	-0.5	-0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-1.1	-0.8	0.0
Knee pain experienced in last month	0.5	0.7	1.7	0.5	0.5	-1.3
Osteoarthritis (self-reported)	0.5	0.7	1.0	1.0	0.6	0.8
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.0	-0.9	-1.7	0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-0.8	-0.0	1.0
Respiratory disease	0.4	0.9	2.3	0.2	0.5	-1.5
Relative age of first facial hair	0.4	0.7	0.9	-0.7	-0.9	-0.9
Fed-up feelings	0.4	0.7	1.5	0.8	1.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	0.6	0.7	0.4
Illnesses of siblings	0.4	0.6	1.5	0.2	-0.3	1.2
Asthma	0.4	0.8	1.5	0.9	1.2	-0.4
Hair/balding pattern: Pattern 4	0.4	0.9	1.1	1.1	0.7	1.0
Birth weight of first child	0.4	0.8	0.9	-0.9	-0.7	1.0
Number of full brothers	0.4	0.5	0.7	-0.7	-0.5	-0.8
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	0.9	1.2	0.1
Medication: Seretide 50 evohaler	0.4	0.4	0.7	0.4	0.7	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.7	-0.7	-0.0	-0.9
Back pain experienced in last month	0.4	0.7	1.8	0.2	0.4	1.3
Breast cancer (self-reported)	0.4	0.5	0.8	0.5	0.7	0.9
Asthma (self-reported)	0.4	0.7	0.9	0.7	1.0	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.8	0.0	-0.8	0.9
High cholesterol (Self-reported)	0.4	0.7	1.0	0.5	0.9	1.0
Alcohol drinker status: Never	0.4	0.5	0.6	0.5	0.8	-0.8
Risk taking	0.4	0.6	1.3	-0.6	-0.2	-1.1
Ever depressed for a whole week	0.4	0.5	0.8	-0.7	-0.9	0.5
Bipolar Disorder (2018)	0.3	0.6	0.9	-0.0	-1.0	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.9	0.5	0.5
Tanning	0.3	3.5	10.0	-0.4	-0.5	-3.2
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.7	-0.8	-0.1
Had menopause	0.3	0.3	0.5	-0.5	-0.7	-0.5
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.5	-0.7	-0.8
Falls in the last year	0.3	0.5	1.3	-0.2	0.2	-1.1
Length of working week for main job	0.3	0.3	0.5	-0.5	-0.7	0.3
Tense / ‘highly strung’	0.3	0.6	0.8	-0.9	-0.4	-0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	0.9	-0.0	0.9
Forced vital capacity (FVC), Best measure	0.3	1.2	1.4	-1.0	-1.2	-1.1
Hypertension (Self-reported)	0.3	0.9	2.3	-0.6	0.5	-1.5
Long-standing illness, disability or infirmity	0.3	0.4	0.7	-0.5	-0.5	-0.8
Friendships satisfaction	0.3	0.4	1.1	-0.2	0.4	-1.0
Medication for cholesterol	0.3	0.4	0.6	-0.1	-0.8	0.7
Miserableness	0.3	0.4	1.0	-0.3	0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.7	-0.5	-0.8	0.1
Medication: Atorvastatin	0.3	0.3	0.8	0.5	0.9	-0.0
Pain experienced in last month	0.3	0.5	0.8	0.9	0.5	0.8
Heart disease (siblings)	0.3	0.3	0.7	0.3	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.1	0.6	-0.3	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.2	-0.7	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.8	-0.1	0.0
Neuroticism (2016)	0.2	0.2	0.5	0.5	0.2	0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	-0.7	-0.6	-0.4
Lung FVC	0.2	0.8	1.4	1.2	0.3	0.9
Hand grip strength (left)	0.2	0.5	1.4	0.0	0.2	-1.2
Average weekly spirits intake	0.2	0.2	0.4	0.6	0.4	0.2
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.8	-0.6	-0.2
Ever had hysterectomy (womb removed)	0.2	0.3	0.4	-0.3	-0.6	-0.6
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.1	0.6	-0.3
Pack years adult smoking proportion	0.2	0.3	0.4	0.7	0.6	-0.4
Taking other prescription medications	0.2	0.4	0.6	-0.6	-0.4	-0.8
High blood pressure	0.2	0.6	1.1	-0.2	0.9	-1.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	-0.7	-0.8	-0.3
High blood pressure (mother)	0.2	0.3	0.8	-0.2	0.1	-0.9
Nervous feelings	0.2	0.4	1.1	-0.1	-0.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.3	0.3	0.8
Pain all over the body in last month	0.2	0.3	0.5	-0.7	-0.1	-0.5
Fluid intelligence score	0.2	0.5	0.9	-0.3	-0.6	-0.9
Number of live births	0.2	0.3	0.5	-0.5	-0.7	-0.3
Peak expiratory flow (PEF)	0.2	0.4	0.8	-0.4	-0.9	0.5
Pulse wave reflection index	0.2	0.3	0.5	0.6	0.7	0.2
Medication: Amlodipine	0.2	0.3	0.6	0.3	0.8	-0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.1	0.7	-0.5
Worry too long after embarrassment	0.2	0.4	0.6	-0.7	-0.8	-0.5
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.1	-0.9	0.1
Qualifications: College or University degree	0.2	0.5	0.8	-0.8	-0.9	0.2
Medication: Blood pressure	0.2	0.3	0.6	-0.5	0.1	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	-0.3	0.1	-0.7
Suffer from ‘nerves’	0.2	0.3	0.7	0.5	0.8	-0.2
Supplements: Vitamin C	0.2	0.3	0.6	-0.8	-0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.3	0.3	0.9
Osteoporosis (self-reported)	0.2	0.3	0.5	0.7	0.6	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.2	-0.1	0.8
Wears glasses or contact lenses	0.2	0.2	0.7	-0.3	-0.0	0.8
Hearing aid user	0.2	0.3	0.5	0.7	0.4	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.7	-0.3	0.1	-0.8
Medication: Lisinopril	0.2	0.2	0.5	0.1	0.7	-0.4
Irritability	0.2	0.3	0.7	0.5	0.3	0.8
Diastolic blood pressure, automated reading	0.2	0.5	0.9	0.0	0.9	-0.7
Worry (Nagel 2018)	0.1	0.1	0.2	-0.4	-0.2	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.8	0.5	0.2	-0.9
HDL Cholesterol	0.1	0.1	0.3	-0.3	-0.3	0.5
Triglycerides	0.1	0.2	0.3	0.6	0.3	0.4
Ulcerative Colitis	0.1	0.2	0.6	0.2	0.8	0.1
Blood Eosinophil Count	0.1	1.0	2.5	0.5	-0.6	1.6
Blood White Count	0.1	1.1	2.6	0.2	0.7	1.6
Waist Hip Ratio (WHR)	0.1	0.7	1.4	0.2	0.7	-1.2
Cardiovascular Disease	0.1	0.2	0.4	0.2	0.5	-0.6
Neuroticism	0.1	0.3	0.6	-0.6	-0.3	-0.8
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.1	-0.2	-0.6
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.3	0.5	-0.3
Average weekly fortified wine intake	0.1	0.1	0.2	0.4	0.2	0.4
Relative age voice broke	0.1	0.1	0.3	0.5	0.1	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	-0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.1	0.5	0.2
Medication: Atenolol	0.1	0.2	0.3	0.2	0.5	0.5
Sitting height	0.1	0.4	1.1	0.0	0.2	1.1
Waist circumference	0.1	0.3	0.5	0.7	0.6	0.2
Diabetes (self-reported)	0.1	0.1	0.1	-0.3	0.3	-0.3
Neuroticism score	0.1	0.2	0.3	-0.6	-0.2	-0.3
Arm fat percentage (right)	0.1	0.3	0.6	0.8	0.6	0.2
Trunk fat-free mass	0.1	0.4	0.6	-0.8	-0.5	-0.7
Father’s age at death	0.1	0.1	0.2	-0.1	-0.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	-0.0	-0.6	0.3
Medication: Cholesterol lowering	0.1	0.2	0.5	-0.0	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.7	0.1	-0.6	0.8
Arm fat mass (right)	0.1	0.2	0.4	0.6	0.4	0.2
Trunk predicted mass	0.1	0.5	0.7	-0.8	-0.5	-0.8
Headache pain in last month	0.1	0.2	0.5	0.1	-0.4	-0.7
Gout (self-reported)	0.1	0.2	0.5	0.2	0.2	0.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	-0.1	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	-0.2	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	-0.4	-0.2	0.1
Medication: Allopurinol	0.1	0.2	0.4	0.1	0.2	0.7
Chest pain or discomfort	0.1	0.1	0.4	-0.3	-0.0	-0.6
Leg pain on walking	0.1	0.1	0.3	0.1	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.2	-0.0	-0.7
Arm fat percentage (left)	0.1	0.5	0.8	0.9	0.7	0.4
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.4	0.1	-0.3
Medication: Gliclazide	0.1	0.1	0.1	-0.4	0.1	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.1	0.4	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.0	-0.5	0.4
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	0.5	-0.3
Age started oral contraceptive pill	0.1	0.1	0.2	0.3	0.3	0.5
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.0	0.1	-0.2
Neuroticism (Nagel 2018)	0.0	0.0	0.0	-0.1	0.0	-0.0
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.4	-0.1	-0.1
Breast Cancer	0.0	0.1	0.2	0.5	-0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	0.2	0.1	0.3
Smoking Status	0.0	0.0	0.1	0.2	0.1	0.1
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.4	-0.2	-0.1
Hair Pigment	0.0	0.4	0.8	-0.5	-0.3	0.9
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	-0.4	-0.1
Leg fat-free mass (left)	0.0	0.0	0.0	-0.1	-0.0	-0.2
Trunk fat percentage	0.0	0.2	0.4	-0.0	-0.4	-0.6
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.3	0.3	0.3
Leg predicted mass (left)	0.0	0.0	0.0	-0.1	-0.0	-0.2
Trunk fat mass	0.0	0.1	0.3	-0.1	-0.3	-0.5
Alcohol usually taken with meals	0.0	0.1	0.1	-0.3	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.2	-0.0	0.1
Qualifications: None of the above	0.0	0.1	0.3	-0.1	-0.0	-0.5
Allergy	0.0	0.1	0.3	-0.3	-0.5	0.1
Weight	0.0	0.1	0.1	-0.2	-0.4	-0.4
Hip circumference	0.0	0.0	0.1	-0.1	-0.3	-0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.0	-0.2	-0.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.2	0.1	-0.3
Loud music exposure frequency	0.0	0.0	0.0	-0.2	0.1	0.1
Body fat percentage	0.0	0.1	0.2	0.1	-0.3	-0.5
Leg fat percentage (right)	0.0	0.0	0.1	0.3	0.1	0.0
Arm fat-free mass (right)	0.0	0.0	0.0	-0.0	-0.1	0.1
Whole body fat mass	0.0	0.0	0.1	0.1	-0.1	-0.3
Leg fat mass (right)	0.0	0.1	0.2	0.4	0.0	0.4
Arm predicted mass (right)	0.0	0.0	0.0	-0.0	-0.1	-0.1
Whole body fat-free mass	0.0	0.2	0.2	-0.5	-0.3	-0.4
Leg fat-free mass (right)	0.0	0.0	0.0	0.1	0.2	0.1
Average weekly red wine intake	0.0	0.1	0.1	-0.3	0.0	0.2
Mood swings	0.0	0.0	0.1	-0.0	0.3	0.2
Whole body water mass	0.0	0.1	0.1	-0.4	-0.3	-0.4
Leg predicted mass (right)	0.0	0.0	0.1	0.2	0.3	0.1
Arm fat mass (left)	0.0	0.2	0.4	0.6	0.4	0.2
Financial situation satisfaction	0.0	0.1	0.1	0.3	0.2	0.1
Basal metabolic rate	0.0	0.1	0.1	-0.3	-0.3	-0.3
Leg fat percentage (left)	0.0	0.1	0.3	0.5	0.3	0.1
Arm fat-free mass (left)	0.0	0.1	0.1	-0.3	-0.3	-0.3
Number of operations (self-reported)	0.0	0.0	0.0	0.1	0.2	0.0
Pack years of smoking	0.0	0.1	0.1	0.3	0.1	-0.2
Leg fat mass (left)	0.0	0.1	0.1	0.3	0.0	0.2
Arm predicted mass (left)	0.0	0.0	0.0	-0.1	-0.1	-0.2

Hub : Genes

DYDC2

Models

Trait associations