[Hub]/) : Traits : Heel T-Score : ← →

chr10:101,291,593-105,647,095

Best TWAS P=4.18e-13 · Best GWAS P=1.25e-26 conditioned to 2.18e-24

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HPS6	0.04	0.03	bslmm	287	0.03	8.9e-05	-3.3	5.9	2.9e-09	-0.01	0.09	0.09	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SEC31B	0.13	0.21	lasso	3	0.20	4.1e-24	5.4	-5.4	8.3e-08	-0.04	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SEC31B	0.32	0.39	lasso	5	0.38	5.1e-33	5.3	-5.3	1.3e-07	-0.04	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP11-316M21.6	0.10	0.04	enet	10	0.03	1.0e-03	4.5	5.2	2.4e-07	0.11	0.30	0.03	FALSE
5	GTEx	Artery Aorta	SEC31B	0.26	0.24	lasso	3	0.23	1.0e-12	5.3	-5.2	1.7e-07	-0.07	1.00	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	CWF19L1	0.29	0.11	enet	15	0.06	1.1e-02	4.5	5.2	2.2e-07	0.13	0.23	0.09	FALSE
7	GTEx	Brain Cortex	NT5C2	0.20	0.04	enet	14	0.05	1.7e-02	-4.1	5.2	1.8e-07	0.03	0.06	0.50	TRUE
8	GTEx	Breast Mammary Tissue	SEC31B	0.17	0.26	lasso	5	0.25	2.9e-13	5.3	-5.2	1.8e-07	-0.04	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Male)	SEC31B	0.13	0.08	lasso	4	0.10	3.0e-03	5.3	-5.3	9.5e-08	-0.04	0.27	0.05	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CWF19L1	0.46	0.19	lasso	8	0.26	7.8e-07	5.0	7.1	1.7e-12	-0.12	0.55	0.05	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	SEC31B	0.23	0.11	enet	13	0.12	9.2e-05	5.3	-5.7	1.1e-08	-0.01	0.75	0.02	FALSE
12	GTEx	Colon Transverse	SEC31B	0.28	0.12	lasso	3	0.09	3.3e-05	5.3	-5.7	1.5e-08	0.04	0.98	0.00	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	SEC31B	0.15	0.21	lasso	4	0.20	8.0e-08	5.4	-5.3	9.5e-08	-0.04	0.96	0.00	FALSE
14	GTEx	Esophagus Mucosa	SEC31B	0.14	0.18	lasso	4	0.17	2.0e-11	5.3	-5.3	9.5e-08	-0.04	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	SEC31B	0.18	0.19	lasso	4	0.20	4.5e-12	5.4	-5.3	9.0e-08	-0.04	1.00	0.00	FALSE
16	GTEx	Lung	C10orf76	0.07	0.00	lasso	3	0.00	7.4e-01	-6.9	-6.9	3.8e-12	-0.06	0.02	0.72	TRUE
17	GTEx	Muscle Skeletal	HIF1AN	0.05	0.06	lasso	1	0.05	1.6e-05	5.3	5.3	1.4e-07	0.05	0.94	0.00	FALSE
18	GTEx	Pituitary	KCNIP2	0.12	-0.01	enet	11	0.01	1.7e-01	-2.1	6.2	6.0e-10	0.01	0.07	0.09	FALSE
19	GTEx	Prostate	SEC31B	0.18	0.14	lasso	2	0.12	6.7e-04	5.3	-5.3	1.4e-07	-0.05	0.39	0.04	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	SEC31B	0.15	0.16	lasso	4	0.15	8.3e-09	5.3	-5.3	9.5e-08	-0.04	0.99	0.00	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	HIF1AN	0.13	0.03	lasso	5	0.02	3.4e-02	5.2	-5.7	9.3e-09	-0.03	0.26	0.03	TRUE
22	GTEx	Spleen	SEC31B	0.21	0.12	lasso	3	0.05	2.3e-02	5.3	-5.6	2.6e-08	-0.03	0.29	0.04	FALSE
23	GTEx	Testis	SEC31B	0.11	0.11	lasso	5	0.08	2.5e-04	5.4	-5.3	8.7e-08	-0.05	0.84	0.01	FALSE
24	GTEx	Testis	NT5C2	0.20	0.03	lasso	8	0.08	2.8e-04	4.3	5.4	5.9e-08	0.05	0.10	0.78	FALSE
25	GTEx	Testis	CWF19L1	0.18	0.11	enet	24	0.12	3.9e-06	4.3	5.9	3.8e-09	0.15	0.46	0.03	FALSE
26	GTEx	Testis	HIF1AN	0.12	0.08	lasso	3	0.06	1.6e-03	5.2	-5.2	1.7e-07	-0.06	0.34	0.03	FALSE
27	GTEx	Thyroid	SEC31B	0.28	0.32	lasso	5	0.31	4.9e-24	5.3	-5.3	9.5e-08	-0.04	1.00	0.00	FALSE
28	GTEx	Uterus	WBP1L	0.43	-0.01	enet	54	0.00	3.1e-01	4.4	-6.3	3.9e-10	0.03	0.05	0.16	TRUE
29	METSIM	Adipose	MRPL43	0.05	0.04	bslmm	422	0.04	1.9e-06	4.3	-5.4	6.3e-08	0.01	0.60	0.36	TRUE
30	METSIM	Adipose	SEC31B	0.15	0.27	enet	29	0.28	1.0e-41	5.3	-5.2	2.2e-07	-0.04	1.00	0.00	FALSE
31	NTR	Blood	HIF1AN	0.02	0.03	lasso	2	0.02	1.4e-07	5.3	-5.2	1.7e-07	-0.06	1.00	0.00	FALSE
32	NTR	Blood	SEC31B	0.03	0.03	lasso	4	0.03	1.1e-10	5.3	-5.6	2.3e-08	-0.04	1.00	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	CWF19L1	0.29	0.33	bslmm	392	0.34	9.3e-45	4.3	5.2	1.9e-07	0.07	1.00	0.00	FALSE
34	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	5.1	5.5	3.4e-08	0.04	0.03	0.96	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	CWF19L1	0.13	0.13	enet	7	0.13	6.2e-26	4.3	5.6	2.2e-08	0.02	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC31B	0.09	0.13	blup	51	0.15	7.1e-29	5.4	-5.1	2.9e-07	-0.05	0.02	0.98	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	HIF1AN	0.07	0.03	blup	40	0.05	4.9e-04	5.3	-5.4	6.9e-08	-0.06	0.02	0.87	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CWF19L1	0.06	0.02	lasso	9	0.04	8.2e-06	-3.8	7.2	4.2e-13	-0.16	0.14	0.24	TRUE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	1.3e-06	5.3	-5.3	1.3e-07	-0.04	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	8.9e-07	5.3	-5.2	1.9e-07	-0.05	0.04	0.96	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C10orf76	0.07	0.05	blup	77	0.05	1.1e-03	3.5	-5.3	1.3e-07	-0.06	0.38	0.17	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC31B	0.14	0.10	lasso	7	0.10	1.6e-06	5.2	-5.2	1.7e-07	-0.06	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	C10orf32	0.21	0.19	lasso	6	0.19	2.2e-21	-4.9	5.2	2.4e-07	-0.05	0.01	0.98	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFB8	0.02	0.01	blup	38	0.01	1.6e-02	4.8	5.2	2.0e-07	0.05	0.02	0.64	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEC31B	0.06	0.06	blup	51	0.06	1.1e-07	5.3	-5.3	1.3e-07	-0.06	0.03	0.97	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C10orf32	0.36	0.32	enet	10	0.32	8.3e-14	-4.6	5.6	2.8e-08	-0.05	0.01	0.98	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CWF19L1	0.21	0.09	enet	2	0.08	3.4e-04	4.3	5.6	2.5e-08	-0.02	0.03	0.05	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SEC31B	0.15	0.14	lasso	12	0.15	8.5e-07	5.3	-5.2	1.5e-07	-0.05	0.03	0.97	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	AS3MT	0.05	0.02	blup	62	0.03	2.1e-03	-4.6	5.6	1.7e-08	0.01	0.02	0.34	FALSE