Best TWAS P=3.02e-147 · Best GWAS P=2.63e-221 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BCO2 | 0.54 | 0.53 | bslmm | 410 | 0.55 | 5.9e-81 | 2.82 | -7.4 | 1.3e-13 | -0.13 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adrenal Gland | NCAM1 | 0.30 | 0.00 | enet | 55 | -0.01 | 6.1e-01 | 2.98 | 9.7 | 2.3e-22 | 0.17 | 0.10 | 0.13 | TRUE |
3 | GTEx | Adrenal Gland | RPS12P21 | 0.29 | 0.29 | enet | 13 | 0.26 | 9.7e-10 | 2.82 | -6.7 | 2.0e-11 | -0.07 | 0.99 | 0.00 | FALSE |
4 | GTEx | Artery Tibial | BCO2 | 0.16 | 0.06 | lasso | 7 | 0.09 | 2.0e-07 | -8.92 | -6.7 | 2.0e-11 | -0.02 | 0.98 | 0.00 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | BCO2 | 0.23 | 0.20 | lasso | 6 | 0.20 | 6.6e-06 | -9.94 | -10.1 | 5.5e-24 | -0.05 | 0.14 | 0.05 | TRUE |
6 | GTEx | Brain Cortex | BCO2 | 0.31 | 0.18 | lasso | 6 | 0.18 | 1.2e-05 | -9.94 | -8.5 | 1.7e-17 | -0.06 | 0.51 | 0.03 | TRUE |
7 | GTEx | Brain Frontal Cortex BA9 | PIH1D2 | 0.30 | 0.00 | enet | 32 | 0.08 | 2.9e-03 | 1.05 | 7.0 | 2.7e-12 | 0.27 | 0.07 | 0.14 | FALSE |
8 | GTEx | Brain Putamen basal ganglia | TIMM8B | 0.28 | 0.01 | lasso | 6 | 0.01 | 2.2e-01 | 2.74 | -6.8 | 1.1e-11 | -0.17 | 0.06 | 0.08 | FALSE |
9 | GTEx | Colon Transverse | BCO2 | 0.15 | 0.02 | lasso | 6 | 0.03 | 1.1e-02 | -7.14 | -9.5 | 2.4e-21 | -0.09 | 0.12 | 0.07 | FALSE |
10 | GTEx | Esophagus Mucosa | TIMM8B | 0.23 | 0.01 | enet | 18 | 0.03 | 3.5e-03 | 0.55 | -7.9 | 2.1e-15 | -0.20 | 0.12 | 0.14 | FALSE |
11 | GTEx | Esophagus Mucosa | BCO2 | 0.10 | 0.04 | enet | 34 | 0.08 | 5.1e-06 | 2.82 | -15.1 | 1.7e-51 | -0.25 | 0.30 | 0.13 | TRUE |
12 | GTEx | Esophagus Muscularis | BCO2 | 0.14 | 0.12 | lasso | 5 | 0.11 | 3.5e-07 | -8.99 | -9.8 | 8.3e-23 | -0.08 | 0.92 | 0.02 | FALSE |
13 | GTEx | Heart Atrial Appendage | BCO2 | 0.22 | 0.13 | enet | 5 | 0.16 | 1.2e-07 | 2.82 | -5.5 | 2.9e-08 | -0.03 | 0.97 | 0.00 | FALSE |
14 | GTEx | Heart Left Ventricle | BCO2 | 0.35 | 0.38 | enet | 29 | 0.40 | 1.2e-22 | 2.82 | -7.1 | 9.9e-13 | -0.09 | 1.00 | 0.00 | FALSE |
15 | GTEx | Heart Left Ventricle | RPS12P21 | 0.26 | 0.26 | enet | 13 | 0.24 | 9.3e-13 | 2.82 | -6.5 | 6.9e-11 | -0.05 | 1.00 | 0.00 | FALSE |
16 | GTEx | Liver | BCO2 | 0.23 | 0.24 | lasso | 3 | 0.22 | 6.7e-07 | 2.82 | -5.1 | 3.1e-07 | -0.03 | 0.58 | 0.02 | FALSE |
17 | GTEx | Muscle Skeletal | RPS12P21 | 0.07 | 0.00 | lasso | 3 | 0.02 | 2.1e-03 | 7.22 | -6.2 | 6.8e-10 | -0.14 | 0.14 | 0.06 | TRUE |
18 | GTEx | Nerve Tibial | RP11-356J5.12 | 0.24 | 0.12 | lasso | 12 | 0.13 | 1.6e-09 | -23.13 | -25.8 | 3.0e-147 | -0.78 | 0.97 | 0.03 | TRUE |
19 | GTEx | Pancreas | NCAM1 | 0.15 | -0.01 | enet | 4 | 0.00 | 4.5e-01 | 8.81 | -9.9 | 3.0e-23 | -0.17 | 0.08 | 0.58 | TRUE |
20 | GTEx | Pancreas | BCO2 | 0.34 | 0.10 | enet | 20 | 0.10 | 6.6e-05 | -7.55 | -10.6 | 3.0e-26 | -0.14 | 0.95 | 0.01 | FALSE |
21 | GTEx | Pancreas | RP11-356J5.12 | 0.25 | 0.04 | lasso | 8 | 0.06 | 1.5e-03 | 7.00 | -12.2 | 5.3e-34 | -0.31 | 0.68 | 0.11 | FALSE |
22 | GTEx | Skin Not Sun Exposed Suprapubic | BCO2 | 0.18 | 0.11 | enet | 4 | 0.12 | 2.7e-07 | -9.94 | -9.9 | 5.4e-23 | -0.07 | 0.98 | 0.00 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | IL18 | 0.11 | 0.07 | lasso | 4 | 0.07 | 1.0e-06 | 7.88 | -7.2 | 8.6e-13 | -0.10 | 0.85 | 0.01 | FALSE |
24 | GTEx | Skin Sun Exposed Lower leg | BCO2 | 0.28 | 0.23 | lasso | 9 | 0.25 | 1.3e-20 | -8.99 | -9.1 | 9.5e-20 | -0.05 | 1.00 | 0.00 | FALSE |
25 | GTEx | Thyroid | RP11-356J5.12 | 0.42 | 0.34 | lasso | 10 | 0.36 | 1.2e-28 | 7.54 | -7.0 | 2.1e-12 | -0.16 | 1.00 | 0.00 | TRUE |
26 | GTEx | Vagina | BCO2 | 0.43 | 0.12 | lasso | 7 | 0.11 | 1.8e-03 | 15.87 | -16.5 | 5.9e-61 | -0.52 | 0.09 | 0.18 | FALSE |
27 | METSIM | Adipose | BCO2 | 0.17 | 0.06 | bslmm | 390 | 0.10 | 5.6e-15 | 2.97 | -8.8 | 8.8e-19 | -0.11 | 1.00 | 0.00 | TRUE |
28 | METSIM | Adipose | DIXDC1 | 0.04 | 0.01 | bslmm | 360 | 0.02 | 1.4e-03 | -1.68 | -6.4 | 1.4e-10 | -0.07 | 0.52 | 0.02 | TRUE |
29 | METSIM | Adipose | NCAM1 | 0.07 | 0.05 | enet | 19 | 0.06 | 6.8e-09 | 10.31 | -7.6 | 3.3e-14 | -0.01 | 1.00 | 0.00 | TRUE |
30 | ROSMAP | Brain Pre-frontal Cortex | CRYAB | 0.03 | 0.00 | blup | 242 | 0.01 | 2.3e-02 | 0.26 | 5.2 | 2.0e-07 | 0.23 | 0.38 | 0.02 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | BCO2 | 0.13 | 0.13 | lasso | 7 | 0.13 | 2.0e-16 | 2.72 | -5.4 | 6.2e-08 | -0.03 | 1.00 | 0.00 | FALSE |
32 | YFS | Blood | CRYAB | 0.02 | 0.00 | enet | 13 | 0.01 | 1.3e-05 | 1.35 | -5.7 | 1.4e-08 | -0.03 | 0.07 | 0.11 | FALSE |
33 | YFS | Blood | DIXDC1 | 0.07 | 0.03 | blup | 353 | 0.06 | 2.7e-19 | 2.17 | 6.3 | 3.9e-10 | 0.21 | 1.00 | 0.00 | FALSE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | BCO2 | 0.05 | 0.03 | enet | 12 | 0.04 | 2.6e-09 | 2.82 | -11.2 | 3.0e-29 | -0.16 | 0.90 | 0.10 | FALSE |
35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IL18 | 0.03 | 0.02 | enet | 7 | 0.02 | 1.6e-05 | 7.32 | -9.8 | 9.7e-23 | -0.16 | 0.89 | 0.02 | FALSE |
36 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | BCO2 | 0.08 | 0.02 | blup | 68 | 0.04 | 6.6e-03 | -10.56 | -9.4 | 3.5e-21 | -0.09 | 0.06 | 0.20 | FALSE |
37 | The Cancer Genome Atlas | Colon Adenocarcinoma | BCO2 | 0.05 | 0.00 | blup | 68 | 0.04 | 2.0e-03 | 6.04 | -7.7 | 1.0e-14 | -0.10 | 0.08 | 0.28 | FALSE |
38 | The Cancer Genome Atlas | Esophageal Carcinoma | C11orf34 | 0.09 | 0.05 | enet | 4 | 0.04 | 2.1e-02 | 5.76 | -7.0 | 2.5e-12 | -0.15 | 0.04 | 0.04 | FALSE |
39 | The Cancer Genome Atlas | Glioblastoma Multiforme | BCO2 | 0.20 | 0.11 | blup | 68 | 0.05 | 1.0e-02 | 1.35 | -7.5 | 8.9e-14 | -0.08 | 0.08 | 0.37 | TRUE |
40 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BCO2 | 0.11 | 0.01 | blup | 69 | 0.01 | 9.0e-02 | 1.00 | 5.3 | 1.1e-07 | 0.10 | 0.04 | 0.07 | FALSE |
41 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL18 | 0.11 | 0.10 | lasso | 2 | 0.10 | 5.9e-12 | 7.32 | -7.6 | 2.7e-14 | -0.11 | 1.00 | 0.00 | FALSE |
42 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BCO2 | 0.06 | 0.04 | enet | 9 | 0.04 | 3.3e-05 | 2.82 | -5.5 | 2.9e-08 | -0.02 | 0.64 | 0.05 | FALSE |
43 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL18 | 0.05 | 0.04 | lasso | 4 | 0.03 | 1.8e-04 | 7.32 | -7.7 | 1.3e-14 | -0.10 | 0.09 | 0.71 | FALSE |
44 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TEX12 | 0.15 | 0.02 | blup | 45 | 0.08 | 4.0e-04 | 3.34 | 7.3 | 3.3e-13 | 0.08 | 0.01 | 0.77 | FALSE |
45 | The Cancer Genome Atlas | Prostate Adenocarcinoma | IL18 | 0.10 | 0.09 | blup | 50 | 0.09 | 1.6e-09 | 7.32 | -7.5 | 7.5e-14 | -0.06 | 1.00 | 0.00 | FALSE |