Hub : Genes

TIMM8B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Putamen basal ganglia 0.279 0.1170 0.00170 0.009 NA -0.011 NA 0.006 0.190 NA 0.76000 NA 0.2200
2 GTEx Esophagus Mucosa 0.226 0.0850 0.00042 0.015 NA 0.031 NA 0.023 0.034 NA 0.00350 NA 0.0110
3 GTEx Heart Left Ventricle 0.229 0.0814 0.00130 0.021 NA 0.069 NA 0.046 0.027 NA 0.00016 NA 0.0017

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.3 2.0 2.4 -1.5 -1.5 -1.2
Bipolar Disorder or Schizophrenia 0.3 0.8 1.9 -0.3 -0.6 -1.4
Depressed Affect (Nagel 2018) 0.6 1.4 2.7 -0.8 -0.9 -1.6
Depression (Nagel 2018) 0.6 0.8 1.8 -1.3 -0.4 -0.7
Intelligence (Savage-Jansen 2018) 0.5 1.6 3.1 1.8 1.3 -0.3
Neuroticism (Nagel 2018) 0.8 1.9 2.6 -1.6 -0.7 -1.6
Schizophrenia (2018) 0.3 0.6 1.1 0.8 0.4 -1.0
Schizophrenia vs Biploar Disorder 0.7 0.9 2.3 1.5 0.3 -0.6
Worry (Nagel 2018) 0.6 1.2 3.1 -0.2 -0.6 -1.8
Alzheimer’s Disease (in mother) 0.5 0.6 1.4 0.2 -1.2 -0.5
Alzheimer’s Disease (in father) 0.4 0.5 0.9 -0.5 0.9 0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.7 -0.3 -0.8 -0.1
Crohns Disease (2017) 0.2 0.4 0.6 -0.8 -0.0 0.7
Irritable Bowel Disease (IBD) 0.8 1.8 3.0 -1.7 -0.7 1.4
Ulcerative Colitis (UC) 1.0 1.9 3.0 -1.7 -0.8 1.4
Major Depression (MDD) 0.8 1.0 2.3 -0.8 0.0 -1.5
Reaction Time 1.6 3.0 3.8 -1.7 -1.9 -1.6
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.7 1.3 0.9 -0.1
Breast Cancer 2.2 5.3 12.2 -3.5 -1.1 1.5
Ovarian Cancer 0.2 0.2 0.4 -0.6 -0.1 -0.4
Prostate Cancer 1.4 2.0 2.9 -1.5 -1.7 0.9
Age at First Birth 0.1 0.1 0.2 -0.2 0.5 0.0
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.8 0.0 -0.5
Body Mass Index (BMI) (2010) 0.2 0.3 0.5 -0.4 -0.6 0.7
Coronary Artery Disease (CAD) 1.6 1.9 5.5 -2.4 0.0 0.5
Crohns Disease (2012) 0.1 0.2 0.3 -0.4 -0.4 -0.6
Mean Putamen Volume 0.1 0.1 0.1 0.3 -0.0 -0.3
Fasting Glucose 0.4 0.5 0.6 0.8 -0.5 -0.7
HbA1C 1.2 1.4 1.9 -1.4 -1.4 -0.6
HDL Cholesterol 0.2 0.3 0.5 -0.5 -0.2 -0.7
LDL Cholesterol 0.2 0.3 0.6 -0.2 0.5 0.8
Lupus 2.2 3.3 8.4 -2.9 -1.1 -0.5
Neuroticism (2016) 1.5 2.2 5.9 -0.8 0.2 -2.4
Primary Biliary Cirrhosis 1.8 2.5 4.7 -0.8 -1.5 -2.2
Rheumatoid Arthritis 0.6 0.8 1.7 0.8 -0.4 -1.3
Schizophrenia (2014) 0.7 1.5 3.2 1.0 -0.6 -1.8
Triglycerides 0.4 0.7 1.4 1.2 0.5 0.5
Type 2 Diabetes (T2D) (2012) 1.7 2.0 2.9 -1.7 0.9 1.5
Ulcerative Colitis 1.0 1.4 3.8 0.4 -0.4 2.0
Blood Eosinophil Count 1.4 10.7 19.4 -3.0 -4.4 -2.0
Blood Platelet Count 0.3 3.3 7.9 1.1 0.9 -2.8
Blood Red Count 1.1 10.4 17.8 4.2 3.6 0.7
Blood White Count 0.3 2.1 2.5 1.6 1.4 -1.4
Heel T-Score 5.0 39.8 62.9 -6.8 -7.9 3.2
BMI 0.1 0.7 1.5 -1.2 -0.7 0.0
Height 0.7 14.1 25.2 1.6 3.8 5.0
Waist Hip Ratio (WHR) 1.4 6.3 14.3 3.8 -0.3 -2.1
Systolic Blood Pressure 0.8 3.8 10.2 -0.3 -3.2 1.1
Smoking Status 1.2 2.8 7.0 -2.6 -0.1 1.2
Allergy or Eczema 2.4 6.3 15.6 1.0 3.9 1.5
Cardiovascular Disease 1.0 3.4 6.9 -1.4 -2.6 1.2
Hypothyroidism (self reported) 0.2 0.6 1.4 -1.2 -0.6 0.1
Respiratory disease 1.6 3.6 10.5 -0.3 3.2 0.2
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.9 -1.4 -0.9 0.2
Lung FEV1/FVC ratio 0.5 2.4 3.9 -2.0 1.2 1.4
Lung FVC 0.0 0.1 0.3 -0.0 -0.6 0.2
Neuroticism 1.1 2.7 4.2 -1.1 -1.7 -2.0
Chronotype (morning person) 0.2 0.4 1.2 -0.2 -1.1 -0.1
Hair Pigment 0.1 2.7 5.1 -2.3 -1.7 -0.2
Tanning 0.1 1.1 1.7 -0.3 -1.2 -1.3
Hand grip strength (left) 0.5 1.4 2.2 0.7 1.5 -1.3
Number of treatments/medications taken 0.8 1.5 2.4 -1.1 0.9 1.6
Average weekly spirits intake 1.8 2.2 6.1 -2.5 0.5 0.4
Sensitivity / hurt feelings 1.0 1.8 5.2 -2.3 -0.0 0.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.3 -1.1 0.4 -0.2
Hearing difficulty/problems: Yes 0.6 0.9 1.1 -0.9 -0.9 -1.1
Relative age of first facial hair 0.2 0.3 0.5 -0.3 0.6 0.7
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.1 -0.5 1.8 1.7
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.4 0.2 1.2 0.5
Ever had hysterectomy (womb removed) 0.8 0.9 1.8 0.2 1.4 0.8
Systolic blood pressure, automated reading 0.4 1.1 2.8 -0.4 -1.7 0.5
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.4 0.1 0.5
Angina 0.6 0.8 1.2 0.8 -0.8 1.1
Medication for hormone replacement therapy 0.1 0.1 0.2 0.5 0.4 -0.1
Vitamin and mineral supplements 2.1 2.8 6.4 -2.5 -0.9 1.2
Supplements: Zinc 0.5 0.5 1.1 -1.1 0.6 -0.1
Medication: Co-codamol 0.5 0.5 0.6 0.8 0.7 -0.6
Medication: Metformin 0.9 1.3 2.6 -1.2 -1.6 -0.3
Diabetes (father) 0.6 0.8 2.3 0.3 -0.1 -1.5
Diabetes (mother) 0.3 0.4 1.1 -0.1 0.2 -1.1
Severe depression (siblings) 0.8 0.9 2.2 0.5 -0.4 -1.5
Pack years adult smoking proportion 0.6 1.0 2.2 0.6 1.5 0.5
Impedance of leg (right) 0.9 4.6 7.7 2.8 2.5 0.0
Leg fat-free mass (left) 0.1 0.4 0.8 -0.9 -0.3 0.6
Trunk fat percentage 0.0 0.0 0.1 -0.2 -0.1 -0.1
Hand grip strength (right) 0.4 1.1 1.5 1.1 1.2 -0.8
Townsend deprivation index at recruitment 1.9 2.6 3.8 -1.9 0.8 1.8
Current tobacco smoking 0.7 1.1 1.8 -0.4 1.2 1.3
Average weekly fortified wine intake 1.0 1.2 1.8 1.2 1.4 0.5
Maternal smoking around birth 1.4 2.0 3.3 1.8 1.5 0.6
Fed-up feelings 0.2 0.4 0.8 0.2 0.4 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.4 -1.2 -0.0 -0.3
Relative age voice broke 0.6 0.9 1.9 0.3 1.4 0.7
Taking other prescription medications 1.6 2.4 5.7 -0.6 2.4 1.1
Age when periods started (menarche) 0.9 2.2 5.1 0.6 1.1 2.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 -0.2 1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 2.1 4.8 7.4 -2.7 -2.5 0.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.5 -0.1 0.2
Qualifications: CSEs or equivalent 0.9 1.2 2.0 -1.2 1.4 0.0
Serious illness, injury or assault to yourself 0.5 0.6 1.4 -0.6 0.3 -1.2
High blood pressure 1.5 4.3 8.0 -1.9 -2.8 1.1
Hayfever, allergic rhinitis or eczema 3.1 6.7 17.9 0.3 4.2 1.4
Multivitamins +/- minerals 2.3 2.9 4.6 2.0 2.1 -0.2
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.2 0.7 -0.0
Supplements: Glucosamine 1.0 1.4 2.4 1.3 1.5 0.3
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.4 1.2 1.1 -0.9
Medication: Atenolol 2.4 3.0 8.5 0.6 -2.9 -0.4
Medication: Levothyroxine sodium 0.5 0.8 1.7 -1.3 -0.2 0.9
Sitting height 0.4 3.2 7.5 0.5 2.7 1.3
Chronic bronchitis/emphysema (father) 0.8 1.0 1.2 1.0 1.1 0.8
High blood pressure (mother) 1.7 2.4 6.1 -2.5 0.0 1.0
Body mass index (BMI) 0.1 0.5 0.7 -0.8 -0.8 -0.2
Impedance of leg (left) 0.9 4.2 6.4 2.5 2.5 0.2
Leg predicted mass (left) 0.1 0.4 0.7 -0.8 -0.3 0.6
Trunk fat mass 0.0 0.0 0.0 -0.0 0.0 0.2
Waist circumference 0.1 0.5 1.2 1.1 0.3 -0.3
Number of incorrect matches in round 0.5 0.8 2.4 -0.3 -1.5 0.1
Past tobacco smoking 0.5 0.9 1.7 1.3 0.2 -1.0
Alcohol usually taken with meals 1.6 2.5 4.9 1.3 -1.0 -2.2
Nervous feelings 0.2 0.4 0.7 0.9 -0.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.4 -1.0 -0.8 -1.5
Hearing difficulty/problems with background noise 0.7 1.1 1.6 -1.1 -0.7 -1.2
Hair/balding pattern: Pattern 2 0.3 0.3 0.7 0.9 0.5 0.1
Had menopause 0.2 0.2 0.3 0.5 0.5 0.4
Had other major operations 2.9 3.6 8.2 -2.9 1.5 0.6
Forced vital capacity (FVC) 0.6 2.2 3.5 1.9 1.7 0.2
Heel bone mineral density (BMD) T-score, automated (right) 1.3 3.0 5.3 -2.3 -1.2 1.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.0 0.3 -0.2 -1.0
Qualifications: None of the above 0.2 0.5 1.3 -0.5 0.3 1.1
Financial difficulties in last 2 years 1.2 1.6 4.7 0.0 2.2 0.3
Mouth/teeth dental problems 0.4 0.6 1.5 0.4 1.2 -0.1
Heart attack 0.3 0.4 0.8 0.1 -0.7 0.9
Allergy 3.7 8.6 22.6 0.5 -4.8 -1.7
Pain all over the body in last month 1.6 1.7 2.6 -1.0 -1.3 -1.6
Diabetes (self-reported) 0.4 0.7 1.6 -1.3 -0.2 0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.6 0.4 0.8 -0.6
Medication: Ramipril 3.0 3.8 9.6 0.3 -3.1 -1.3
Medication: Simvastatin 0.4 0.6 1.0 0.8 -0.1 -1.0
Fluid intelligence score 1.3 2.8 7.1 2.7 1.0 0.4
Illnesses of siblings 2.0 2.9 7.7 2.8 -0.1 -0.9
Neuroticism score 1.3 2.7 3.9 -1.5 -1.4 -2.0
Weight 0.0 0.2 0.5 -0.1 0.4 0.7
Impedance of arm (right) 0.2 1.1 2.1 1.4 0.6 -0.9
Arm fat percentage (right) 0.2 0.8 1.3 -0.1 -1.2 -1.0
Trunk fat-free mass 0.2 1.2 3.0 0.2 0.8 1.7
Hip circumference 0.1 0.6 1.6 -0.0 1.2 0.4
Time employed in main current job 1.5 1.8 2.5 -1.2 -1.6 -1.1
Alcohol intake versus 10 years previously 0.6 0.9 2.5 -1.6 0.1 0.6
Father’s age at death 0.3 0.4 0.7 0.5 -0.8 0.4
Worrier / anxious feelings 1.2 2.3 3.5 -0.5 -1.8 -1.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.0 -0.4 -1.0 -0.2
Falls in the last year 1.0 1.3 2.0 -1.1 -0.9 -1.4
Hair/balding pattern: Pattern 3 0.4 0.6 0.9 1.0 -0.3 -0.9
Number of live births 1.8 2.5 4.6 -2.1 0.5 1.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.3 0.9 1.1 0.1
Pulse rate 0.6 1.0 2.8 -0.4 1.7 0.1
Happiness 0.4 0.5 1.2 -1.1 0.2 -0.6
Noisy workplace 0.9 1.2 2.4 1.0 -1.6 -0.3
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.4 1.9 -0.0 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 0.8 0.9 -0.8 -0.4
Mouth/teeth dental problems: Dentures 0.5 0.9 2.4 0.0 0.6 1.6
Asthma 2.9 5.6 15.0 -0.3 3.9 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.6 -1.6 -1.0 0.7
Medication: Cholesterol lowering 0.3 0.5 0.8 0.5 -0.7 -0.9
Depression (self-reported) 0.1 0.1 0.3 0.4 -0.5 0.1
Medication: Lansoprazole 0.3 0.3 0.6 0.7 -0.4 -0.4
Prospective memory result 2.7 3.3 9.0 -3.0 -0.1 0.9
Lung cancer (father) 2.8 3.3 6.1 2.5 1.1 -1.6
Illnesses of mother 0.7 0.9 1.6 0.8 -0.6 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 3.7 0.8 1.9 0.6
Pulse wave Arterial Stiffness index 1.5 1.7 3.0 -1.5 -1.7 -0.1
Impedance of arm (left) 0.2 0.9 1.9 0.9 1.4 0.0
Arm fat mass (right) 0.0 0.0 0.0 -0.2 -0.2 0.0
Trunk predicted mass 0.2 1.3 3.3 0.2 0.8 1.8
Standing height 0.6 5.5 8.8 1.5 3.0 2.3
Length of working week for main job 0.1 0.1 0.2 0.4 -0.3 0.3
Exposure to tobacco smoke at home 1.1 1.2 3.2 -1.8 0.3 -0.6
Breastfed as a baby 0.1 0.1 0.2 0.1 0.2 -0.5
Tense / ‘highly strung’ 1.0 1.6 2.3 -0.6 -1.5 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.9 1.0 0.3 -0.9
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 0.7 0.8 0.3
Birth weight of first child 0.5 1.0 2.4 -0.7 0.3 -1.5
Peak expiratory flow (PEF) 0.3 0.8 1.6 0.5 1.3 0.6
Pulse wave reflection index 2.8 3.4 6.9 -1.3 -2.6 -1.3
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.9 -0.9 -0.0 -0.2
Loud music exposure frequency 2.1 2.3 5.8 0.8 -0.7 -2.4
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.2 2.0 0.7 0.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.2 -1.1 -0.7 -0.6
Blood clot in the leg (DVT) 0.2 0.3 0.8 -0.2 0.3 -0.9
Medication: Paracetamol 0.7 1.2 3.3 -1.8 -0.5 0.3
Headache pain in last month 0.4 0.7 1.5 -0.8 0.1 -1.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.7 -0.4 1.3 -0.2
Glaucoma (self-reported) 1.3 1.5 2.7 0.1 1.3 1.6
Gout (self-reported) 0.7 0.9 2.0 0.7 1.4 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.4 -0.4 -0.7 0.4
Medication: Amlodipine 0.5 0.7 1.4 -0.7 -1.2 0.3
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.3 -1.8 0.6 -0.2
Birth weight 1.2 2.5 6.9 0.8 2.6 -0.4
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.3 1.0 1.1 -0.7
High blood pressure (siblings) 1.1 1.5 4.5 -2.1 -0.2 -0.1
Forced vital capacity (FVC), Best measure 0.6 2.2 4.7 1.3 2.2 0.6
Body fat percentage 0.0 0.1 0.3 -0.0 -0.3 -0.6
Leg fat percentage (right) 0.2 0.6 1.1 0.8 -0.1 -1.1
Arm fat-free mass (right) 0.2 1.2 2.9 -0.6 0.7 1.7
Exposure to tobacco smoke outside home 3.9 5.1 11.2 -0.0 -2.1 -3.3
Comparative body size at age 10 0.1 0.2 0.4 -0.2 -0.6 0.4
Number of full brothers 0.3 0.4 1.1 -1.0 0.1 0.1
Worry too long after embarrassment 1.2 2.0 4.2 -2.0 0.1 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.8 5.1 -0.1 2.2 1.8
Wheeze or whistling in the chest in last year 2.1 3.7 10.0 -0.3 3.2 1.1
Number of children fathered 1.8 2.0 3.2 1.8 -0.5 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 3.5 1.0 -0.2 -1.9
Age at first live birth 1.0 1.7 2.7 -0.8 -1.6 -1.4
Pulse wave peak to peak time 1.6 1.9 3.3 1.5 1.8 0.3
Health satisfaction 0.2 0.3 0.6 0.4 0.2 -0.7
Shortness of breath walking on level ground 1.8 2.1 5.5 -2.3 0.7 0.6
Qualifications: College or University degree 0.3 1.1 2.5 1.6 -0.8 -0.1
Eye problems/disorders: None of the above 0.7 0.8 1.2 -1.0 0.4 -1.1
Mouth/teeth dental problems: Loose teeth 1.6 1.9 3.3 0.4 1.8 1.5
Emphysema/chronic bronchitis 5.4 6.1 11.3 -0.6 2.6 3.4
Medication for pain relief, constipation, heartburn 0.3 0.6 1.3 1.1 0.7 -0.1
Neck or shoulder pain in last month 0.4 0.6 1.1 -0.2 0.8 -1.0
Medication: Blood pressure 1.0 1.7 4.2 -0.5 -2.0 0.9
Angina (self-reported) 0.5 0.6 1.3 0.6 -0.5 1.2
Migraine (self-reported) 0.1 0.1 0.2 -0.2 -0.0 0.4
Medication: Ibuprofen 1.4 1.7 3.3 -1.8 -0.7 1.2
Medication: Allopurinol 0.2 0.3 0.4 0.0 0.7 0.6
Medication: Omeprazole 0.5 0.6 1.3 0.8 0.2 -1.1
Medication: Seretide 50 evohaler 1.7 2.0 3.6 -1.2 1.9 1.0
Mean time to correctly identify matches 3.5 6.7 10.7 -2.1 -3.3 -2.2
Heart disease (mother) 0.9 1.1 1.6 -0.9 1.0 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.4 -0.6 -0.7 -0.1
Whole body fat mass 0.0 0.0 0.0 -0.2 -0.1 0.1
Leg fat mass (right) 0.0 0.1 0.2 0.4 -0.2 -0.5
Arm predicted mass (right) 0.2 1.2 2.7 -0.6 0.6 1.6
Pulse rate, automated reading 1.2 3.8 7.2 0.9 2.7 -1.8
Alcohol intake frequency. 0.7 1.6 3.3 -1.8 -0.7 0.9
Comparative height size at age 10 0.5 3.0 4.0 1.7 1.4 2.0
Number of full sisters 0.6 0.7 1.0 -0.6 1.0 0.8
Suffer from ‘nerves’ 1.0 1.6 2.6 -1.6 0.5 -1.3
Overall health rating 0.1 0.1 0.2 -0.5 0.1 0.3
Chest pain or discomfort 0.6 0.9 2.6 -1.6 0.0 0.2
Had major operations 0.5 0.5 1.1 -0.7 -0.3 1.0
Age at last live birth 1.3 2.0 3.1 -1.5 -1.8 -0.7
Family relationship satisfaction 0.1 0.1 0.2 0.4 0.3 0.2
Leg pain on walking 2.2 2.8 5.2 -0.9 1.5 2.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.7 -0.6 0.5 -0.8
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.1 -0.6 -1.1 -0.1
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 4.9 0.2 1.4 2.2
Medication: Aspirin 0.4 0.5 1.4 -0.2 -1.2 0.0
Supplements: Vitamin C 0.7 0.8 1.2 0.9 -0.6 -1.1
Knee pain experienced in last month 0.1 0.2 0.4 0.1 0.7 0.4
Hypertension (Self-reported) 1.3 3.7 8.7 -1.1 -3.0 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.9 0.2 -0.4 -1.7
Illnesses of father: Heart disease 1.0 1.3 2.3 1.5 -1.2 -0.6
Illnesses of siblings: Diabetes 4.6 5.7 8.3 -2.9 1.9 2.3
Smoking status: Previous 1.4 2.1 4.9 -2.2 -0.8 0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.7 3.4 6.9 1.1 2.6 1.5
Whole body fat-free mass 0.1 0.8 2.1 -0.4 0.4 1.4
Leg fat-free mass (right) 0.1 0.6 1.1 -1.1 -0.2 0.9
Arm fat percentage (left) 0.2 0.6 1.0 -0.4 -1.0 -0.8
Average weekly red wine intake 2.5 3.7 4.9 1.6 -1.9 -2.2
Handedness (chirality/laterality): Left-handed 0.0 0.1 0.2 -0.1 -0.0 0.4
Mood swings 2.1 3.7 6.5 -0.3 -2.5 -2.2
Loneliness, isolation 1.0 1.3 3.6 -1.9 -0.2 -0.5
Long-standing illness, disability or infirmity 0.1 0.2 0.4 -0.3 0.3 0.7
Ever had bowel cancer screening 1.1 1.3 2.1 -1.0 -0.9 1.4
Diabetes diagnosed by doctor 0.8 1.2 3.4 -1.8 -0.5 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.1 0.5 1.0 0.5
Friendships satisfaction 1.3 1.6 3.0 -0.8 -1.7 -1.1
Qualifications: nursing, teaching 0.5 0.8 1.5 0.5 -0.7 -1.2
Commuting to job workplace: Walk 1.0 1.1 2.0 0.9 1.4 0.7
Eye problems/disorders: Cataract 0.3 0.4 0.8 0.9 -0.2 0.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 -0.7 -0.9 -0.4
Medication for cholesterol 0.5 0.8 2.3 -0.1 1.5 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.8 1.6 1.3 0.8 -0.2
Back pain experienced in last month 0.6 0.9 1.5 -0.4 1.2 1.0
Mineral and other dietary supplements 3.7 5.0 8.5 -2.9 -2.2 -1.3
Breast cancer (self-reported) 0.3 0.3 0.7 -0.8 0.5 0.1
Asthma (self-reported) 2.6 5.1 13.3 -0.3 3.6 1.4
Osteoporosis (self-reported) 0.2 0.3 0.3 0.6 0.4 -0.5
Osteoarthritis (self-reported) 1.4 1.9 3.2 1.8 1.6 0.0
Medication: Aspirin 0.5 0.7 2.0 0.0 -1.4 0.2
Medication: Gliclazide 1.0 1.1 1.7 -1.2 -1.3 0.1
Illnesses of father: None of the above (group 1) 0.5 0.6 0.8 -0.7 0.7 0.9
Smoking status: Current 0.9 1.4 2.5 -0.1 1.6 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 4.3 2.1 0.9 -0.1
Whole body water mass 0.1 0.8 2.2 -0.3 0.4 1.5
Leg predicted mass (right) 0.1 0.6 1.1 -1.1 -0.2 0.9
Arm fat mass (left) 0.0 0.1 0.2 -0.4 -0.4 -0.0
Number of self-reported non-cancer illnesses 0.4 0.6 1.3 -0.6 1.1 0.5
Average weekly champagne plus white wine intake 0.3 0.4 1.1 1.0 0.2 -0.2
Miserableness 1.9 3.3 4.2 -1.9 -2.1 -1.5
Guilty feelings 0.8 1.2 2.2 -1.2 -0.1 -1.5
Wears glasses or contact lenses 0.9 1.0 2.0 0.8 -1.4 -0.7
Ever taken oral contraceptive pill 2.3 2.6 7.7 -2.8 -0.3 0.1
Hearing aid user 0.5 0.6 1.1 -0.7 -0.4 1.1
Mother’s age at death 0.9 1.1 3.0 0.3 0.5 1.7
Financial situation satisfaction 0.4 0.6 1.3 -0.1 1.1 0.6
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.4 0.5 -0.1 -0.6
Commuting to job workplace: Public transport 0.5 0.6 1.1 -0.8 -0.2 -1.0
Eye problems/disorders: Glaucoma 2.5 2.9 3.8 1.2 1.9 1.9
Medication: Blood pressure 1.8 3.4 9.5 0.6 -3.1 -0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.8 1.7 1.1 -0.4
Supplements: Fish oil (including cod liver oil) 3.0 3.9 5.3 1.7 2.3 1.9
High cholesterol (Self-reported) 0.2 0.4 0.9 0.9 -0.5 0.2
Medication: Bendroflumethiazide 2.9 4.4 11.9 -0.8 -3.4 -0.8
Medication: Paracetamol 1.0 1.5 3.7 -1.9 0.0 0.9
Medication: Lisinopril 0.8 1.0 2.2 -0.9 -1.5 -0.4
Medication: Atorvastatin 0.9 1.1 2.5 -0.8 -1.6 -0.3
Illnesses of father: High blood pressure 0.9 1.1 2.7 -0.2 -1.6 -0.8
Alcohol drinker status: Never 0.0 0.0 0.1 0.1 0.3 0.1
Ever smoked 0.5 0.9 1.4 -1.1 0.5 1.2
Basal metabolic rate 0.1 0.6 1.7 -0.2 0.4 1.3
Leg fat percentage (left) 0.1 0.3 0.6 0.4 -0.1 -0.8
Arm fat-free mass (left) 0.2 0.8 2.0 -0.0 0.6 1.4
Number of operations (self-reported) 0.5 0.7 1.9 0.2 1.4 0.3
Average weekly beer plus cider intake 1.0 1.4 2.9 -0.5 1.7 1.0
Irritability 1.5 2.5 2.9 -1.3 -1.7 -1.7
Risk taking 0.3 0.4 0.7 0.7 0.9 0.1
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 0.4 0.1 -0.7
Fractured/broken bones in last 5 years 3.2 4.1 7.6 2.2 0.3 -2.8
Age started oral contraceptive pill 0.5 0.6 0.7 0.8 0.8 0.7
Diastolic blood pressure, automated reading 0.3 1.0 2.0 -1.1 -1.4 -0.1
Ever depressed for a whole week 0.4 0.5 1.2 0.1 0.4 -1.1
Unable to work because of sickness or disability 2.3 2.9 6.5 -0.8 2.5 1.3
Commuting to job workplace: Cycle 0.5 0.7 1.1 1.0 0.8 0.5
Myopia 0.3 0.4 0.8 0.1 -0.9 -0.6
Vascular/heart problems diagnosed by doctor 1.4 3.9 7.9 1.6 2.8 -1.1
Cholesterol lowering medication 0.5 0.8 1.8 1.3 0.7 0.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 0.8 -0.2 -1.1
Pain experienced in last month 0.8 1.3 2.9 1.7 0.6 0.8
Supplements: Calcium 1.6 1.7 3.2 0.3 1.8 1.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.1 -0.1 -0.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 0.2 -0.8 0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.6 0.1 0.2 -1.2
Heart disease (siblings) 1.6 2.0 3.2 -0.4 1.6 1.8
Alcohol drinker status: Previous 0.1 0.1 0.1 -0.4 -0.1 0.2
Pack years of smoking 0.6 0.8 1.4 1.0 1.2 0.4
Impedance of whole body 0.5 2.3 4.6 1.5 2.1 -0.0
Leg fat mass (left) 0.0 0.0 0.1 0.1 -0.2 -0.3
Arm predicted mass (left) 0.3 1.5 3.6 -0.1 1.0 1.9