Hub : Genes

TIMM8B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Putamen basal ganglia	0.279	0.1170	0.00170	0.009	NA	-0.011	NA	0.006	0.190	NA	0.76000	NA	0.2200
2	GTEx	Esophagus Mucosa	0.226	0.0850	0.00042	0.015	NA	0.031	NA	0.023	0.034	NA	0.00350	NA	0.0110
3	GTEx	Heart Left Ventricle	0.229	0.0814	0.00130	0.021	NA	0.069	NA	0.046	0.027	NA	0.00016	NA	0.0017

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.0	2.4	-1.5	-1.5	-1.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-0.3	-0.6	-1.4
Depressed Affect (Nagel 2018)	0.6	1.4	2.7	-0.8	-0.9	-1.6
Depression (Nagel 2018)	0.6	0.8	1.8	-1.3	-0.4	-0.7
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.1	1.8	1.3	-0.3
Neuroticism (Nagel 2018)	0.8	1.9	2.6	-1.6	-0.7	-1.6
Schizophrenia (2018)	0.3	0.6	1.1	0.8	0.4	-1.0
Schizophrenia vs Biploar Disorder	0.7	0.9	2.3	1.5	0.3	-0.6
Worry (Nagel 2018)	0.6	1.2	3.1	-0.2	-0.6	-1.8
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	0.2	-1.2	-0.5
Alzheimer’s Disease (in father)	0.4	0.5	0.9	-0.5	0.9	0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.3	-0.8	-0.1
Crohns Disease (2017)	0.2	0.4	0.6	-0.8	-0.0	0.7
Irritable Bowel Disease (IBD)	0.8	1.8	3.0	-1.7	-0.7	1.4
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.7	-0.8	1.4
Major Depression (MDD)	0.8	1.0	2.3	-0.8	0.0	-1.5
Reaction Time	1.6	3.0	3.8	-1.7	-1.9	-1.6
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	1.3	0.9	-0.1
Breast Cancer	2.2	5.3	12.2	-3.5	-1.1	1.5
Ovarian Cancer	0.2	0.2	0.4	-0.6	-0.1	-0.4
Prostate Cancer	1.4	2.0	2.9	-1.5	-1.7	0.9
Age at First Birth	0.1	0.1	0.2	-0.2	0.5	0.0
Bipolar Disorder (2011)	0.3	0.3	0.6	-0.8	0.0	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	-0.4	-0.6	0.7
Coronary Artery Disease (CAD)	1.6	1.9	5.5	-2.4	0.0	0.5
Crohns Disease (2012)	0.1	0.2	0.3	-0.4	-0.4	-0.6
Mean Putamen Volume	0.1	0.1	0.1	0.3	-0.0	-0.3
Fasting Glucose	0.4	0.5	0.6	0.8	-0.5	-0.7
HbA1C	1.2	1.4	1.9	-1.4	-1.4	-0.6
HDL Cholesterol	0.2	0.3	0.5	-0.5	-0.2	-0.7
LDL Cholesterol	0.2	0.3	0.6	-0.2	0.5	0.8
Lupus	2.2	3.3	8.4	-2.9	-1.1	-0.5
Neuroticism (2016)	1.5	2.2	5.9	-0.8	0.2	-2.4
Primary Biliary Cirrhosis	1.8	2.5	4.7	-0.8	-1.5	-2.2
Rheumatoid Arthritis	0.6	0.8	1.7	0.8	-0.4	-1.3
Schizophrenia (2014)	0.7	1.5	3.2	1.0	-0.6	-1.8
Triglycerides	0.4	0.7	1.4	1.2	0.5	0.5
Type 2 Diabetes (T2D) (2012)	1.7	2.0	2.9	-1.7	0.9	1.5
Ulcerative Colitis	1.0	1.4	3.8	0.4	-0.4	2.0
Blood Eosinophil Count	1.4	10.7	19.4	-3.0	-4.4	-2.0
Blood Platelet Count	0.3	3.3	7.9	1.1	0.9	-2.8
Blood Red Count	1.1	10.4	17.8	4.2	3.6	0.7
Blood White Count	0.3	2.1	2.5	1.6	1.4	-1.4
Heel T-Score	5.0	39.8	62.9	-6.8	-7.9	3.2
BMI	0.1	0.7	1.5	-1.2	-0.7	0.0
Height	0.7	14.1	25.2	1.6	3.8	5.0
Waist Hip Ratio (WHR)	1.4	6.3	14.3	3.8	-0.3	-2.1
Systolic Blood Pressure	0.8	3.8	10.2	-0.3	-3.2	1.1
Smoking Status	1.2	2.8	7.0	-2.6	-0.1	1.2
Allergy or Eczema	2.4	6.3	15.6	1.0	3.9	1.5
Cardiovascular Disease	1.0	3.4	6.9	-1.4	-2.6	1.2
Hypothyroidism (self reported)	0.2	0.6	1.4	-1.2	-0.6	0.1
Respiratory disease	1.6	3.6	10.5	-0.3	3.2	0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.9	-1.4	-0.9	0.2
Lung FEV1/FVC ratio	0.5	2.4	3.9	-2.0	1.2	1.4
Lung FVC	0.0	0.1	0.3	-0.0	-0.6	0.2
Neuroticism	1.1	2.7	4.2	-1.1	-1.7	-2.0
Chronotype (morning person)	0.2	0.4	1.2	-0.2	-1.1	-0.1
Hair Pigment	0.1	2.7	5.1	-2.3	-1.7	-0.2
Tanning	0.1	1.1	1.7	-0.3	-1.2	-1.3
Hand grip strength (left)	0.5	1.4	2.2	0.7	1.5	-1.3
Number of treatments/medications taken	0.8	1.5	2.4	-1.1	0.9	1.6
Average weekly spirits intake	1.8	2.2	6.1	-2.5	0.5	0.4
Sensitivity / hurt feelings	1.0	1.8	5.2	-2.3	-0.0	0.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	-1.1	0.4	-0.2
Hearing difficulty/problems: Yes	0.6	0.9	1.1	-0.9	-0.9	-1.1
Relative age of first facial hair	0.2	0.3	0.5	-0.3	0.6	0.7
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	3.1	-0.5	1.8	1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.4	0.2	1.2	0.5
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	0.2	1.4	0.8
Systolic blood pressure, automated reading	0.4	1.1	2.8	-0.4	-1.7	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	0.1	0.5
Angina	0.6	0.8	1.2	0.8	-0.8	1.1
Medication for hormone replacement therapy	0.1	0.1	0.2	0.5	0.4	-0.1
Vitamin and mineral supplements	2.1	2.8	6.4	-2.5	-0.9	1.2
Supplements: Zinc	0.5	0.5	1.1	-1.1	0.6	-0.1
Medication: Co-codamol	0.5	0.5	0.6	0.8	0.7	-0.6
Medication: Metformin	0.9	1.3	2.6	-1.2	-1.6	-0.3
Diabetes (father)	0.6	0.8	2.3	0.3	-0.1	-1.5
Diabetes (mother)	0.3	0.4	1.1	-0.1	0.2	-1.1
Severe depression (siblings)	0.8	0.9	2.2	0.5	-0.4	-1.5
Pack years adult smoking proportion	0.6	1.0	2.2	0.6	1.5	0.5
Impedance of leg (right)	0.9	4.6	7.7	2.8	2.5	0.0
Leg fat-free mass (left)	0.1	0.4	0.8	-0.9	-0.3	0.6
Trunk fat percentage	0.0	0.0	0.1	-0.2	-0.1	-0.1
Hand grip strength (right)	0.4	1.1	1.5	1.1	1.2	-0.8
Townsend deprivation index at recruitment	1.9	2.6	3.8	-1.9	0.8	1.8
Current tobacco smoking	0.7	1.1	1.8	-0.4	1.2	1.3
Average weekly fortified wine intake	1.0	1.2	1.8	1.2	1.4	0.5
Maternal smoking around birth	1.4	2.0	3.3	1.8	1.5	0.6
Fed-up feelings	0.2	0.4	0.8	0.2	0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-1.2	-0.0	-0.3
Relative age voice broke	0.6	0.9	1.9	0.3	1.4	0.7
Taking other prescription medications	1.6	2.4	5.7	-0.6	2.4	1.1
Age when periods started (menarche)	0.9	2.2	5.1	0.6	1.1	2.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.2	1.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	7.4	-2.7	-2.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.5	-0.1	0.2
Qualifications: CSEs or equivalent	0.9	1.2	2.0	-1.2	1.4	0.0
Serious illness, injury or assault to yourself	0.5	0.6	1.4	-0.6	0.3	-1.2
High blood pressure	1.5	4.3	8.0	-1.9	-2.8	1.1
Hayfever, allergic rhinitis or eczema	3.1	6.7	17.9	0.3	4.2	1.4
Multivitamins +/- minerals	2.3	2.9	4.6	2.0	2.1	-0.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.2	0.7	-0.0
Supplements: Glucosamine	1.0	1.4	2.4	1.3	1.5	0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	1.4	1.2	1.1	-0.9
Medication: Atenolol	2.4	3.0	8.5	0.6	-2.9	-0.4
Medication: Levothyroxine sodium	0.5	0.8	1.7	-1.3	-0.2	0.9
Sitting height	0.4	3.2	7.5	0.5	2.7	1.3
Chronic bronchitis/emphysema (father)	0.8	1.0	1.2	1.0	1.1	0.8
High blood pressure (mother)	1.7	2.4	6.1	-2.5	0.0	1.0
Body mass index (BMI)	0.1	0.5	0.7	-0.8	-0.8	-0.2
Impedance of leg (left)	0.9	4.2	6.4	2.5	2.5	0.2
Leg predicted mass (left)	0.1	0.4	0.7	-0.8	-0.3	0.6
Trunk fat mass	0.0	0.0	0.0	-0.0	0.0	0.2
Waist circumference	0.1	0.5	1.2	1.1	0.3	-0.3
Number of incorrect matches in round	0.5	0.8	2.4	-0.3	-1.5	0.1
Past tobacco smoking	0.5	0.9	1.7	1.3	0.2	-1.0
Alcohol usually taken with meals	1.6	2.5	4.9	1.3	-1.0	-2.2
Nervous feelings	0.2	0.4	0.7	0.9	-0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.4	-1.0	-0.8	-1.5
Hearing difficulty/problems with background noise	0.7	1.1	1.6	-1.1	-0.7	-1.2
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.9	0.5	0.1
Had menopause	0.2	0.2	0.3	0.5	0.5	0.4
Had other major operations	2.9	3.6	8.2	-2.9	1.5	0.6
Forced vital capacity (FVC)	0.6	2.2	3.5	1.9	1.7	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	5.3	-2.3	-1.2	1.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.0	0.3	-0.2	-1.0
Qualifications: None of the above	0.2	0.5	1.3	-0.5	0.3	1.1
Financial difficulties in last 2 years	1.2	1.6	4.7	0.0	2.2	0.3
Mouth/teeth dental problems	0.4	0.6	1.5	0.4	1.2	-0.1
Heart attack	0.3	0.4	0.8	0.1	-0.7	0.9
Allergy	3.7	8.6	22.6	0.5	-4.8	-1.7
Pain all over the body in last month	1.6	1.7	2.6	-1.0	-1.3	-1.6
Diabetes (self-reported)	0.4	0.7	1.6	-1.3	-0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.4	0.8	-0.6
Medication: Ramipril	3.0	3.8	9.6	0.3	-3.1	-1.3
Medication: Simvastatin	0.4	0.6	1.0	0.8	-0.1	-1.0
Fluid intelligence score	1.3	2.8	7.1	2.7	1.0	0.4
Illnesses of siblings	2.0	2.9	7.7	2.8	-0.1	-0.9
Neuroticism score	1.3	2.7	3.9	-1.5	-1.4	-2.0
Weight	0.0	0.2	0.5	-0.1	0.4	0.7
Impedance of arm (right)	0.2	1.1	2.1	1.4	0.6	-0.9
Arm fat percentage (right)	0.2	0.8	1.3	-0.1	-1.2	-1.0
Trunk fat-free mass	0.2	1.2	3.0	0.2	0.8	1.7
Hip circumference	0.1	0.6	1.6	-0.0	1.2	0.4
Time employed in main current job	1.5	1.8	2.5	-1.2	-1.6	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	2.5	-1.6	0.1	0.6
Father’s age at death	0.3	0.4	0.7	0.5	-0.8	0.4
Worrier / anxious feelings	1.2	2.3	3.5	-0.5	-1.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.4	-1.0	-0.2
Falls in the last year	1.0	1.3	2.0	-1.1	-0.9	-1.4
Hair/balding pattern: Pattern 3	0.4	0.6	0.9	1.0	-0.3	-0.9
Number of live births	1.8	2.5	4.6	-2.1	0.5	1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	0.9	1.1	0.1
Pulse rate	0.6	1.0	2.8	-0.4	1.7	0.1
Happiness	0.4	0.5	1.2	-1.1	0.2	-0.6
Noisy workplace	0.9	1.2	2.4	1.0	-1.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.4	1.9	-0.0	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	0.8	0.9	-0.8	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.9	2.4	0.0	0.6	1.6
Asthma	2.9	5.6	15.0	-0.3	3.9	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.6	-1.6	-1.0	0.7
Medication: Cholesterol lowering	0.3	0.5	0.8	0.5	-0.7	-0.9
Depression (self-reported)	0.1	0.1	0.3	0.4	-0.5	0.1
Medication: Lansoprazole	0.3	0.3	0.6	0.7	-0.4	-0.4
Prospective memory result	2.7	3.3	9.0	-3.0	-0.1	0.9
Lung cancer (father)	2.8	3.3	6.1	2.5	1.1	-1.6
Illnesses of mother	0.7	0.9	1.6	0.8	-0.6	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.7	0.8	1.9	0.6
Pulse wave Arterial Stiffness index	1.5	1.7	3.0	-1.5	-1.7	-0.1
Impedance of arm (left)	0.2	0.9	1.9	0.9	1.4	0.0
Arm fat mass (right)	0.0	0.0	0.0	-0.2	-0.2	0.0
Trunk predicted mass	0.2	1.3	3.3	0.2	0.8	1.8
Standing height	0.6	5.5	8.8	1.5	3.0	2.3
Length of working week for main job	0.1	0.1	0.2	0.4	-0.3	0.3
Exposure to tobacco smoke at home	1.1	1.2	3.2	-1.8	0.3	-0.6
Breastfed as a baby	0.1	0.1	0.2	0.1	0.2	-0.5
Tense / ‘highly strung’	1.0	1.6	2.3	-0.6	-1.5	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	1.0	0.3	-0.9
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	0.7	0.8	0.3
Birth weight of first child	0.5	1.0	2.4	-0.7	0.3	-1.5
Peak expiratory flow (PEF)	0.3	0.8	1.6	0.5	1.3	0.6
Pulse wave reflection index	2.8	3.4	6.9	-1.3	-2.6	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	-0.9	-0.0	-0.2
Loud music exposure frequency	2.1	2.3	5.8	0.8	-0.7	-2.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.2	2.0	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.2	-1.1	-0.7	-0.6
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.2	0.3	-0.9
Medication: Paracetamol	0.7	1.2	3.3	-1.8	-0.5	0.3
Headache pain in last month	0.4	0.7	1.5	-0.8	0.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	-0.4	1.3	-0.2
Glaucoma (self-reported)	1.3	1.5	2.7	0.1	1.3	1.6
Gout (self-reported)	0.7	0.9	2.0	0.7	1.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.4	-0.7	0.4
Medication: Amlodipine	0.5	0.7	1.4	-0.7	-1.2	0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.3	-1.8	0.6	-0.2
Birth weight	1.2	2.5	6.9	0.8	2.6	-0.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.3	1.0	1.1	-0.7
High blood pressure (siblings)	1.1	1.5	4.5	-2.1	-0.2	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.2	4.7	1.3	2.2	0.6
Body fat percentage	0.0	0.1	0.3	-0.0	-0.3	-0.6
Leg fat percentage (right)	0.2	0.6	1.1	0.8	-0.1	-1.1
Arm fat-free mass (right)	0.2	1.2	2.9	-0.6	0.7	1.7
Exposure to tobacco smoke outside home	3.9	5.1	11.2	-0.0	-2.1	-3.3
Comparative body size at age 10	0.1	0.2	0.4	-0.2	-0.6	0.4
Number of full brothers	0.3	0.4	1.1	-1.0	0.1	0.1
Worry too long after embarrassment	1.2	2.0	4.2	-2.0	0.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	5.1	-0.1	2.2	1.8
Wheeze or whistling in the chest in last year	2.1	3.7	10.0	-0.3	3.2	1.1
Number of children fathered	1.8	2.0	3.2	1.8	-0.5	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.5	1.0	-0.2	-1.9
Age at first live birth	1.0	1.7	2.7	-0.8	-1.6	-1.4
Pulse wave peak to peak time	1.6	1.9	3.3	1.5	1.8	0.3
Health satisfaction	0.2	0.3	0.6	0.4	0.2	-0.7
Shortness of breath walking on level ground	1.8	2.1	5.5	-2.3	0.7	0.6
Qualifications: College or University degree	0.3	1.1	2.5	1.6	-0.8	-0.1
Eye problems/disorders: None of the above	0.7	0.8	1.2	-1.0	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.3	0.4	1.8	1.5
Emphysema/chronic bronchitis	5.4	6.1	11.3	-0.6	2.6	3.4
Medication for pain relief, constipation, heartburn	0.3	0.6	1.3	1.1	0.7	-0.1
Neck or shoulder pain in last month	0.4	0.6	1.1	-0.2	0.8	-1.0
Medication: Blood pressure	1.0	1.7	4.2	-0.5	-2.0	0.9
Angina (self-reported)	0.5	0.6	1.3	0.6	-0.5	1.2
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.0	0.4
Medication: Ibuprofen	1.4	1.7	3.3	-1.8	-0.7	1.2
Medication: Allopurinol	0.2	0.3	0.4	0.0	0.7	0.6
Medication: Omeprazole	0.5	0.6	1.3	0.8	0.2	-1.1
Medication: Seretide 50 evohaler	1.7	2.0	3.6	-1.2	1.9	1.0
Mean time to correctly identify matches	3.5	6.7	10.7	-2.1	-3.3	-2.2
Heart disease (mother)	0.9	1.1	1.6	-0.9	1.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	-0.6	-0.7	-0.1
Whole body fat mass	0.0	0.0	0.0	-0.2	-0.1	0.1
Leg fat mass (right)	0.0	0.1	0.2	0.4	-0.2	-0.5
Arm predicted mass (right)	0.2	1.2	2.7	-0.6	0.6	1.6
Pulse rate, automated reading	1.2	3.8	7.2	0.9	2.7	-1.8
Alcohol intake frequency.	0.7	1.6	3.3	-1.8	-0.7	0.9
Comparative height size at age 10	0.5	3.0	4.0	1.7	1.4	2.0
Number of full sisters	0.6	0.7	1.0	-0.6	1.0	0.8
Suffer from ‘nerves’	1.0	1.6	2.6	-1.6	0.5	-1.3
Overall health rating	0.1	0.1	0.2	-0.5	0.1	0.3
Chest pain or discomfort	0.6	0.9	2.6	-1.6	0.0	0.2
Had major operations	0.5	0.5	1.1	-0.7	-0.3	1.0
Age at last live birth	1.3	2.0	3.1	-1.5	-1.8	-0.7
Family relationship satisfaction	0.1	0.1	0.2	0.4	0.3	0.2
Leg pain on walking	2.2	2.8	5.2	-0.9	1.5	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.7	-0.6	0.5	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	-0.6	-1.1	-0.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.9	0.2	1.4	2.2
Medication: Aspirin	0.4	0.5	1.4	-0.2	-1.2	0.0
Supplements: Vitamin C	0.7	0.8	1.2	0.9	-0.6	-1.1
Knee pain experienced in last month	0.1	0.2	0.4	0.1	0.7	0.4
Hypertension (Self-reported)	1.3	3.7	8.7	-1.1	-3.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.9	0.2	-0.4	-1.7
Illnesses of father: Heart disease	1.0	1.3	2.3	1.5	-1.2	-0.6
Illnesses of siblings: Diabetes	4.6	5.7	8.3	-2.9	1.9	2.3
Smoking status: Previous	1.4	2.1	4.9	-2.2	-0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	6.9	1.1	2.6	1.5
Whole body fat-free mass	0.1	0.8	2.1	-0.4	0.4	1.4
Leg fat-free mass (right)	0.1	0.6	1.1	-1.1	-0.2	0.9
Arm fat percentage (left)	0.2	0.6	1.0	-0.4	-1.0	-0.8
Average weekly red wine intake	2.5	3.7	4.9	1.6	-1.9	-2.2
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.2	-0.1	-0.0	0.4
Mood swings	2.1	3.7	6.5	-0.3	-2.5	-2.2
Loneliness, isolation	1.0	1.3	3.6	-1.9	-0.2	-0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.3	0.3	0.7
Ever had bowel cancer screening	1.1	1.3	2.1	-1.0	-0.9	1.4
Diabetes diagnosed by doctor	0.8	1.2	3.4	-1.8	-0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.1	0.5	1.0	0.5
Friendships satisfaction	1.3	1.6	3.0	-0.8	-1.7	-1.1
Qualifications: nursing, teaching	0.5	0.8	1.5	0.5	-0.7	-1.2
Commuting to job workplace: Walk	1.0	1.1	2.0	0.9	1.4	0.7
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.9	-0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.7	-0.9	-0.4
Medication for cholesterol	0.5	0.8	2.3	-0.1	1.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.6	1.3	0.8	-0.2
Back pain experienced in last month	0.6	0.9	1.5	-0.4	1.2	1.0
Mineral and other dietary supplements	3.7	5.0	8.5	-2.9	-2.2	-1.3
Breast cancer (self-reported)	0.3	0.3	0.7	-0.8	0.5	0.1
Asthma (self-reported)	2.6	5.1	13.3	-0.3	3.6	1.4
Osteoporosis (self-reported)	0.2	0.3	0.3	0.6	0.4	-0.5
Osteoarthritis (self-reported)	1.4	1.9	3.2	1.8	1.6	0.0
Medication: Aspirin	0.5	0.7	2.0	0.0	-1.4	0.2
Medication: Gliclazide	1.0	1.1	1.7	-1.2	-1.3	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	-0.7	0.7	0.9
Smoking status: Current	0.9	1.4	2.5	-0.1	1.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.3	2.1	0.9	-0.1
Whole body water mass	0.1	0.8	2.2	-0.3	0.4	1.5
Leg predicted mass (right)	0.1	0.6	1.1	-1.1	-0.2	0.9
Arm fat mass (left)	0.0	0.1	0.2	-0.4	-0.4	-0.0
Number of self-reported non-cancer illnesses	0.4	0.6	1.3	-0.6	1.1	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.1	1.0	0.2	-0.2
Miserableness	1.9	3.3	4.2	-1.9	-2.1	-1.5
Guilty feelings	0.8	1.2	2.2	-1.2	-0.1	-1.5
Wears glasses or contact lenses	0.9	1.0	2.0	0.8	-1.4	-0.7
Ever taken oral contraceptive pill	2.3	2.6	7.7	-2.8	-0.3	0.1
Hearing aid user	0.5	0.6	1.1	-0.7	-0.4	1.1
Mother’s age at death	0.9	1.1	3.0	0.3	0.5	1.7
Financial situation satisfaction	0.4	0.6	1.3	-0.1	1.1	0.6
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.5	-0.1	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.1	-0.8	-0.2	-1.0
Eye problems/disorders: Glaucoma	2.5	2.9	3.8	1.2	1.9	1.9
Medication: Blood pressure	1.8	3.4	9.5	0.6	-3.1	-0.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	1.7	1.1	-0.4
Supplements: Fish oil (including cod liver oil)	3.0	3.9	5.3	1.7	2.3	1.9
High cholesterol (Self-reported)	0.2	0.4	0.9	0.9	-0.5	0.2
Medication: Bendroflumethiazide	2.9	4.4	11.9	-0.8	-3.4	-0.8
Medication: Paracetamol	1.0	1.5	3.7	-1.9	0.0	0.9
Medication: Lisinopril	0.8	1.0	2.2	-0.9	-1.5	-0.4
Medication: Atorvastatin	0.9	1.1	2.5	-0.8	-1.6	-0.3
Illnesses of father: High blood pressure	0.9	1.1	2.7	-0.2	-1.6	-0.8
Alcohol drinker status: Never	0.0	0.0	0.1	0.1	0.3	0.1
Ever smoked	0.5	0.9	1.4	-1.1	0.5	1.2
Basal metabolic rate	0.1	0.6	1.7	-0.2	0.4	1.3
Leg fat percentage (left)	0.1	0.3	0.6	0.4	-0.1	-0.8
Arm fat-free mass (left)	0.2	0.8	2.0	-0.0	0.6	1.4
Number of operations (self-reported)	0.5	0.7	1.9	0.2	1.4	0.3
Average weekly beer plus cider intake	1.0	1.4	2.9	-0.5	1.7	1.0
Irritability	1.5	2.5	2.9	-1.3	-1.7	-1.7
Risk taking	0.3	0.4	0.7	0.7	0.9	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.4	0.1	-0.7
Fractured/broken bones in last 5 years	3.2	4.1	7.6	2.2	0.3	-2.8
Age started oral contraceptive pill	0.5	0.6	0.7	0.8	0.8	0.7
Diastolic blood pressure, automated reading	0.3	1.0	2.0	-1.1	-1.4	-0.1
Ever depressed for a whole week	0.4	0.5	1.2	0.1	0.4	-1.1
Unable to work because of sickness or disability	2.3	2.9	6.5	-0.8	2.5	1.3
Commuting to job workplace: Cycle	0.5	0.7	1.1	1.0	0.8	0.5
Myopia	0.3	0.4	0.8	0.1	-0.9	-0.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	7.9	1.6	2.8	-1.1
Cholesterol lowering medication	0.5	0.8	1.8	1.3	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	0.8	-0.2	-1.1
Pain experienced in last month	0.8	1.3	2.9	1.7	0.6	0.8
Supplements: Calcium	1.6	1.7	3.2	0.3	1.8	1.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.1	-0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.2	-0.8	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	0.1	0.2	-1.2
Heart disease (siblings)	1.6	2.0	3.2	-0.4	1.6	1.8
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.4	-0.1	0.2
Pack years of smoking	0.6	0.8	1.4	1.0	1.2	0.4
Impedance of whole body	0.5	2.3	4.6	1.5	2.1	-0.0
Leg fat mass (left)	0.0	0.0	0.1	0.1	-0.2	-0.3
Arm predicted mass (left)	0.3	1.5	3.6	-0.1	1.0	1.9